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Overexpression of Rhodiola crenulata glutathione peroxidase 5 increases cold tolerance and enhances the pharmaceutical value of the hairy roots Gene (IF 3.5) Pub Date : 2024-04-12 Kai Hou, Lu Cao, Wen Li, Zhi-Hui Fang, Daqiang Sun, Zhigang Guo, Lipeng Zhang
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Identification of a novel RNA transcript TISPL upregulated by stressors that stimulate ATF4 Gene (IF 3.5) Pub Date : 2024-04-12 Yutaro Wakabayashi, Aika Shimono, Yuki Terauchi, Chao Zeng, Michiaki Hamada, Kentaro Semba, Shinya Watanabe, Kosuke Ishikawa
Cells sense, respond, and adapt to environmental conditions that cause stress. In a previous study using HeLa cells, we isolated reporter cells responding to the endoplasmic reticulum (ER) stress inducers, thapsigargin and tunicamycin, using a highly sensitive promoter trap vector system. Splinkerette PCR and 5′ rapid amplification of cDNA ends (5′ RACE) identified a novel transcript that is upregulated
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Transcriptomic profiling analysis of the effect of palmitic acid on 3D spheroids of β-like cells derived from induced pluripotent stem cells Gene (IF 3.5) Pub Date : 2024-04-10 Lisa Morisseau, Fumiya Tokito, Mathilde Lucas, Stéphane Poulain, Soo Hyeon Kim, Valérie Plaisance, Valérie Pawlowski, Cécile Legallais, Rachid Jellali, Yasuyuki Sakai, Amar Abderrahmani, Eric Leclerc
Type 2 diabetes (T2D) is posing a serious public health concern with a considerable impact on human life and health expenditures worldwide. The disease develops when insulin plasma level is insufficient for coping insulin resistance, caused by the decline of pancreatic β-cell function and mass. In β-cells, the lipotoxicity exerted by saturated free fatty acids in particular palmitate (PA), which is
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Yak IGFBP3 promotes hepatocyte proliferation through PI3K-Akt signaling pathway Gene (IF 3.5) Pub Date : 2024-04-09 Nanchi Zhang, Ling Zhang, Ying Peng, Fang Fu, Li Wang, Qundi Mei, Yong Wei
IGFBP3 (Insulin-like growth factor binding protein 3) constitutes a crucial constituent of the insulin-like growth factor (IGF), which are intimately associated with the organism's growth and development processes. Despite its significance, the precise function of IGFBP3 in yak liver development remains largely unexplored. In the present study, we systematically examined the expression profile of in
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POI-associated EIF4ENIF1 mutations exhibit impaired translation regulation abilities Gene (IF 3.5) Pub Date : 2024-04-09 Yuxi Ding, Shuya Chen, Jing Jin, Yujun Sun, Chunfang Chu, Kehkooi Kee, Mingwei Xin, Lin Li
Various genetic variants have been found to be associated with the clinical onset of premature ovarian insufficiency (POI). However, when measured , the functional influence of the variants can be difficult to determine. By whole-exome sequencing (WES) of 93 patients with sporadic POI, we found a missense variant c.623G > A;p.R208H in the gene. prediction of the variant using different algorithms suggested
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Receptor for advanced glycation end products polymorphisms in coronary artery ectasia Gene (IF 3.5) Pub Date : 2024-04-07 Ezgi Irmak Aslan, Gulcin Ozkara, Onur Kilicarslan, Ozgur Selim Ser, Cem Bostan, Ahmet Yildiz, Ayca Diren Borekcioglu, Oguz Ozturk, Ozlem Kucukhuseyin, Hulya Yilmaz Aydogan
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Breast cancer drug resistance: Decoding the roles of Hippo pathway crosstalk Gene (IF 3.5) Pub Date : 2024-04-07 Fariba Dehghanian, Laleh Ebrahimi Ghahnavieh, Amirhossein Naghsh Nilchi, Sheyda Khalilian, Rezvan Joonbakhsh
The most significant factors that lead to cancer-related death in breast cancer (BC) patients include drug resistance, migration, invasion, and metastasis. Several signaling pathways are involved in the development of BC. The different types of BC are initially sensitive to chemotherapy, and drug resistance can occur through multiple molecular mechanisms. Regardless of developing targeted Therapy,
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A novel cancer-germline gene DAZL promotes progression and cisplatin resistance of non-small cell lung cancer by upregulating JAK2 and MCM8 Gene (IF 3.5) Pub Date : 2024-04-06 Lin Zhou, Mai Nhu Uyen Le, Yan Du, Xi Chen, Miao Jin, Hu Xiang, Liang′e Xia, Jianlin Zhou, Jun He, Yichong Ning
Germline-specific genes are usually activated in cancer cells and drive cancer progression; such genes are called cancer-germline or cancer-testis genes. The RNA-binding protein DAZL is predominantly expressed in germ cells and plays a role in gametogenesis as a translational activator or repressor. However, its expression and role in non-small cell lung cancer (NSCLC) are unknown. Here, mining of
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Cold-adapted Exiguobacterium sibiricum K1 as a potential bioinoculant in cold regions: Physiological and genomic elucidation of biocontrol and plant growth promotion Gene (IF 3.5) Pub Date : 2024-04-05 Sareeka Kumari, Anil Kumar, Ayush Lepcha, Rakshak Kumar
The scarcity of soil nutrient availability under cold conditions of Himalayan regions needs a sustainable approach for better crop yields. The cold-adapted bacteria, K1, with the potential to produce several plant growth-promoting (PGP) attributes, nitrogen fixation, indole acetic acid production, phosphate and potassium solubilization at 10 °C can provide an opportunity to promote crop yield improvement
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Exploring Myc puzzle: Insights into cancer, stem cell biology, and PPI networks Gene (IF 3.5) Pub Date : 2024-04-05 Nima Ghasemi, Hossein Azizi
“The grand orchestrator,” “Universal Amplifier,” “double-edged sword,” and “Undruggable” are just some of the Myc oncogene so-called names. It has been around 40 years since the discovery of the Myc, and it remains in the mainstream of cancer treatment drugs. Myc is part of basic helix–loop–helix leucine zipper (bHLH-LZ) superfamily proteins, and its dysregulation can be seen in many malignant human
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The immunoregulatory property of mesenchymal stem cells in Crocin treatment by expression modulation of microRNA-155, microRNA-21, microRNA-23b, microRNA-126a, and their target inflammatory genes Gene (IF 3.5) Pub Date : 2024-04-05 Zeinab Rostami, Mansoore Saharkhiz, Mohsen Khorashadizadeh, Malaksima Ayadilord, Mohsen Naseri
Mesenchymal stem cells (MSCs) have high priority in clinical applications for treatment of immune disorders because of their immunomodulatory function. A lot of researches have currently been undertaken to enhance the stemness capacities of the cells and pick an excellent type of MSCs for clinical approaches. This study aims to assess the immunomodulatory related MicroRNAs (miRNAs) expression as well
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ATPR induces acute promyelocytic leukemia cells differentiation and cycle arrest via the lncRNA CONCR/DDX11/PML-RARα signaling axis Gene (IF 3.5) Pub Date : 2024-04-04 Shen Liu, Wenjing Zhan, Xiong He, Mengjia Hao, Wenwen Shen, Xiaoyue Zhang, Meng Wang, Zihan Li, Ruirui Hou, Ziyao Ou, Yubin Feng, Feihu Chen
Acute promyelocytic leukemia (APL) is a type of acute myeloid leukemia (AML) with a high mortality rate, and the production of PML-RARα fusion protein is the cause of its pathogenesis. Our group has synthesized a novel compound, 4-amino-2-trifluoromethyl-phenyl retinate (ATPR), by structural modification of All-trans retinoic acid (ATRA), which has strong cell differentiation-inducing effects and inhibits
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Sudden cardiac death triggered by minimal alcohol consumption in the context of novel PPA2 mutations in 2 unrelated families Gene (IF 3.5) Pub Date : 2024-04-04 Cristina Gómez González, Iván del Campo Cano, Ana Isabel Fernández-Avila, Maria Paz Suárez – Mier, María José Sagastizábal, Reyes Álvarez García-Rovés, Irene Méndez Fernández, Silvia Vilches, Miriam Centeno Jiménez, Ana Siles Sánchez –Manjavacas, Ana Usano Carrasco, Emiliano Gonzalez-Vioque, Juan Pablo Ochoa, Constancio Medrano, Esther González López, Pablo García-Pavía, Javier Bermejo, María Angeles
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Circular RNAs: Epigenetic regulators of PTEN expression and function in cancer Gene (IF 3.5) Pub Date : 2024-04-04 Mohammad-Mojtaba Farazi, Saeideh Jafarinejad-Farsangi, Zahra Miri Karam, Maryam Gholizadeh, Maryam Hadadi, Abolfazl Yari
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Exploring the mechanism of Corbrin capsules in the intervention of AKI-COVID-19 based on network pharmacology combined with GEO dataset Gene (IF 3.5) Pub Date : 2024-04-04 Xiu-juan Qin, Wen-jie Hu, Xian-jin Xu
This study used network pharmacology and the Gene Expression Omnibus (GEO) database to investigate the therapeutic effects of Corbrin capsules on acute kidney injury (AKI)-COVID-19 (coronavirus disease 2019). The active constituents and specific molecular targets of Corbrin capsules were obtained from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) and Swiss Target Prediction databases
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Dynamic analysis of SARS-CoV-2 evolution based on different countries Gene (IF 3.5) Pub Date : 2024-04-03 Binghan Xiao, Linhuan Wu, Qinglan Sun, Chang Shu, Songnian Hu
Since late 2019, COVID-19 has significantly impacted the world. Understanding the evolution of SARS-CoV-2 is crucial for protecting against future infectious pathogens. In this study, we conducted a comprehensive chronological analysis of SARS-CoV-2 evolution by examining mutation prevalence from the source countries of VOCs: United Kingdom, India, Brazil, South Africa, plus two countries: United States
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Advances in the evolution research and genetic breeding of peanut Gene (IF 3.5) Pub Date : 2024-04-03 Hui Zhang, Yueyi Tang, Yunlai Yue, Yong Chen
Peanut is an important cash crop used in oil, food and feed in our country. The rapid development of sequencing technology has promoted the research on the related aspects of peanut genetic breeding. This paper reviews the research progress of peanut origin and evolution, genetic breeding, molecular markers and their applications, genomics, QTL mapping and genome selection techniques. The main problems
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Identification of activating transcription factor 6 (ATF6) as a novel prognostic biomarker and potential target in oral squamous cell carcinoma Gene (IF 3.5) Pub Date : 2024-04-03 Yan Wu, Qiang Xie, Lifeng Wu, Zhijia Li, Xiaojing Li, Lan Zhang, Bin Zhang
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Splice site recognition - deciphering Exon-Intron transitions for genetic insights using Enhanced integrated Block-Level gated LSTM model Gene (IF 3.5) Pub Date : 2024-04-03 Mohemmed Sha, Mohamudha Parveen Rahamathulla
Bioinformatics is a contemporary interdisciplinary area focused on analyzing the growing number of genome sequences. Gene variants are differences in DNA sequences among individuals within a population. Splice site recognition is a crucial step in the process of gene expression, where the coding sequences of genes are joined together to form mature messenger RNA (mRNA). These genetic variants that
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Gene expression patterns of Sirtuin family members (SIRT1 TO SIRT7): Insights into pathogenesis and prognostic of Myelodysplastic neoplasm Gene (IF 3.5) Pub Date : 2024-04-03 João Vitor Caetano Goes, Mateus de Aguiar Viana, Leticia Rodrigues Sampaio, Clarissa Brenda Alves Cavalcante, Mayara Magna de Lima Melo, Roberta Taiane Germano de Oliveira, Daniela de Paula Borges, Paola Gyuliane Gonçalves, Ronald Feitosa Pinheiro, Howard Lopes Ribeiro-Junior
To assess and validate the gene expression profile of (, , , , , , and ) in relation to the pathogenesis and prognostic progression of Myelodysplastic neoplasm (MDS). Eighty bone marrow samples of patients with MDS were diagnosed according to WHO 2022 and IPSS-R criteria. Ten bone marrow samples were obtained from elderly healthy volunteers and used as control samples. Gene expression levels of all
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A positive selection at binding site 501 in the B.1 lineage might have triggered the highly infectious sub-lineages of SARS-CoV-2 Gene (IF 3.5) Pub Date : 2024-04-02 Basant K. Tiwary
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The vesicle trafficking gene, OsRab7, is critical for pollen development and male fertility in cytoplasmic male-sterility rice Gene (IF 3.5) Pub Date : 2024-04-02 Suping Ying, Yunting Tang, Wei Yang, Zhao Hu, Ruifeng Huang, Jie Ding, Xiangyun Yi, Jiawei Niu, Zihan Chen, Ting Wang, Wei Liu, Xiaojue Peng
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Exploring non-coding genetic variability in ACE2: Functional annotation and in vitro validation of regulatory variants Gene (IF 3.5) Pub Date : 2024-04-02 Agnese Giovannetti, Sara Lazzari, Manuel Mangoni, Alice Traversa, Tommaso Mazza, Chiara Parisi, Viviana Caputo
The surge in human whole-genome sequencing data has facilitated the study of non-coding region variations, yet understanding their biological significance remains a challenge. We used a computational workflow to assess the regulatory potential of non-coding variants, with a particular focus on the ( gene. This gene is crucial in physiological processes and serves as the entry point for severe acute
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GPCR-mediated regulation of beige adipocyte formation: Implications for obesity and metabolic health Gene (IF 3.5) Pub Date : 2024-03-30 Yuanxu Cui, Hugo Auclair, Rong He, Qiang Zhang
Obesity and its associated complications pose a significant burden on health. The non-shivering thermogenesis (NST) and metabolic capacity properties of brown adipose tissue (BAT), which are distinct from those of white adipose tissue (WAT), in combating obesity and its related metabolic diseases has been well documented. However, beige adipose tissue, the third and relatively novel type of adipose
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Corrigendum to “Comparative analysis of the difference in flavonoid metabolic pathway during coloring between red-yellow and red sweet cherry (Prunus avium L.)” [Gene 880 (2023) 147602] Gene (IF 3.5) Pub Date : 2024-03-30 Liwei Chu, Wei Zheng, Jiao Wang, Zhen Wang, Wei Zhao, Baixia Zhao, Guohui Xu, Min Xiao, Xin Lou, Fengrong Pan, Yongbin Zhou
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Effect of MSX1 on the cellular function of cardiomyocytes Gene (IF 3.5) Pub Date : 2024-03-29 Huang Linhuan, Zhong Liangying, Lin Shaobin, Zhu Caixia, Cai Danlei, Huang Siqi, Hong Peiming, Kong Shu, Xie Yingjun, Luo Yanmin
(Muscle Segment Homeobox 1) has pleiotropic effects in various tissues, including cardiomyocytes, while the effect of on cardiomyocyte cellular function was not well known. In this study, we used AC16 cell culture, real-time fluorescence quantitative PCR (qPCR), protein blotting (Western blot), flow cytometry apoptosis assay and lactate dehydrogenase (LDH) ELISA (Enzyme-Linked Immunosorbnent Assay)
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Chronic sleep fragmentation reduces left ventricular contractile function and alters gene expression related to innate immune response and circadian rhythm in the mouse heart Gene (IF 3.5) Pub Date : 2024-03-29 Ling Zhong, Jie Zhang, Jielin Yang, Bo Li, Xinghao Yi, John R. Speakman, Shan Gao, Ming Li
Sleep disorders have emerged as a widespread public health concern, primarily due to their association with an increased risk of developing cardiovascular diseases. Our previous research indicated a potential direct impact of insufficient sleep duration on cardiac remodeling in children and adolescents. Nevertheless, the underlying mechanisms behind the link between sleep fragmentation (SF) and cardiac
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Genome-wide identification and characterization of DIRIGENT gene family (CcDIR) in pigeonpea (Cajanus cajan L.) provide insights on their spatial expression pattern and relevance to stress response Gene (IF 3.5) Pub Date : 2024-03-28 Narasimham Dokka, Shaily Tyagi, M.K Ramkumar, Maniraj Rathinam, Kameshwaran Senthil, Rohini Sreevathsa
This study is a thorough characterization of pigeonpea dirigent gene () family, an important component of the lignin biosynthesis pathway. Genome-wide analysis identified 25 genes followed by a range of analytical approaches employed to unravel their structural and functional characteristics. Structural examination revealed a classic single exon and no intron arrangement in DIRs contributing to our
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Knocking out FAM20C in pre-osteoblasts leads to up-regulation of osteoclast differentiation to affect long bone development Gene (IF 3.5) Pub Date : 2024-03-27 Lili Jiang, Xinpeng Liu, Lixue Liu, Lide Su, Zeyu Lu, Hong Zhang, Yuyao Guo, Wenxuan Zhang, Shujian Zhang, Wenxia Xu, Jiahui Zhang, Kai Zhang, Yuanbo Zhan, Xiaohua Xie, Runhang Li, Xinhe Dong, Han Jin, Bin Zhang, Ying Li
Family with sequence similarity 20 member C (FAM20C) is a Golgi casein kinase that phosphorylates extracellularly-secreted regulatory proteins involved in bone development and mineralization, but its specific role in bone development is still largely unknown. In this study, to examine the specific mechanisms that FAM20C influences bone development, we cross-bred Osx-Cre with FAM20C mice to establish
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The minor allele of ANGPTL8 rs2278426 has a protective effect against CAD in T2DM patients Gene (IF 3.5) Pub Date : 2024-03-27 Aslihan Gizem Bilgin, Berkay Ekici, Aybike Sena Ozuynuk-Ertugrul, Aycan Fahri Erkan, Neslihan Coban
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Identification and preliminary validation of differently expressed genes as candidate biomarkers associated with atherosclerosis Gene (IF 3.5) Pub Date : 2024-03-26 Liqin Zhou, Liping Zhou, Qiliang Chen, Congying Chen, Yuanyuan Qian, Dayong Lou, Huanjie Ma, Suying Wang
Atherosclerosis (AS) is the primary cause of deadly cardio-cerebro vascular diseases globally. This study aims to explore the key differentially expressed genes (DEGs), potentially serving as predictive biomarkers for AS. Microarray datasets were retrieved from the GEO database for DEGs and DE-miRNAs identification. Then biological function of DEGs were elucidated based on gene ontology (GO) and KEGG
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Assembly and comparative analysis of the first complete mitochondrial genome of the invasive water hyacinth, Eichhornia crassipes Gene (IF 3.5) Pub Date : 2024-03-26 Xiangyan He, Zhihao Qian, Andrew W. Gichira, Jinming Chen, Zhizhong Li
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Analysis of differentially expressed lncRNAs and mRNAs associated with slow‑transit constipation Gene (IF 3.5) Pub Date : 2024-03-26 Yuanxin Miao, Xiongwei Xie, Yonglian Zhang, Xu Ma, Xiaoxuan Zhu, Rong Li, Jinhua Bi, Rui Duan, Xu Ai
Slow transit constipation (STC) is a refractory gastrointestinal disease, accounting for approximately 13 ∼ 37 % of chronic constipation. However, the molecular mechanism of STC remains poorly understood. Herein, this study aims to identify the key mRNAs and lncRNAs associated with STC. To this end, we performed high-throughput RNA sequencing to identify differentially expressed (DE) mRNAs and lncRNAs
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Corrigendum to “Transcriptomic Changes in Soybean Underlying Growth Promotion and Defense Against Cyst Nematode After Bacillus simplex Sneb545 Treatment” [Gene 898 (2024) 148080] Gene (IF 3.5) Pub Date : 2024-03-25 Wenshu Kang, Yuxi Duan, Piao Lei
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Transcriptomic regulatory analysis of skeletal muscle development in landrace pigs Gene (IF 3.5) Pub Date : 2024-03-24 Mubin Yu, Yanqin Feng, Jiamao Yan, Xiaoyuan Zhang, Zhe Tian, Tao Wang, Junjie Wang, Wei Shen
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Genetic association of novel SNPs in HK-1 (rs201626997) and HK-3 (rs143604141) with type 2 diabetes mellitus in Bangladeshi population Gene (IF 3.5) Pub Date : 2024-03-23 Md Tarikul Islam, Md Abdullah Al Mamun Khan, Shahidur Rahman, K. M. Kaderi Kibria
Hexokinase, a key enzyme in glycolysis, has isoforms like HK-1, HK-2, HK-3, and Glucokinase. Unpublished exome sequencing data showed that two novel polymorphisms in HK-1 rs201626997 (G/T) and HK-3 rs143604141 (G/A) exist in the Bangladeshi population. We investigated the possible relationship of these SNPs with T2DM. Peripheral blood samples from the study participants were used to isolate their genomic
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S100A6 mediated epithelial-mesenchymal transition affects chemosensitivity of colorectal cancer to oxaliplatin Gene (IF 3.5) Pub Date : 2024-03-22 Chunying Zhang, Menglu Zeng, Yihan Xu, Bihan Huang, Pengchong Shi, Xianjin Zhu, Yingping Cao
To investigate the mechanism by which S100 calcium-binding protein A6 (S100A6) affects colorectal cancer (CRC) cells to oxaliplatin (L-OHP) chemotherapy, and to explore new strategies for CRC treatment. S100A6 expression was assessed in both parental and L-OHP-resistant CRC cells using western blotting, quantitative real-time polymerase chain reaction (qRT-PCR), and enzyme-linked immunosorbent assays
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Identify CTBP1-DT as an immunological biomarker that promotes lipid synthesis and apoptosis resistance in KIRC Gene (IF 3.5) Pub Date : 2024-03-21 Haolin Li, Mintian Fei, Yi Zhang, Qili Xu, Rui Feng, Jing Cao, Yan Qu, Haibing Xiao
Recently, mounting evidence has highlighted the essential function of the C-terminal binding protein-1 divergent transcript (CTBP1-DT) in malignancies. However, its role in kidney renal clear cell carcinoma (KIRC) remains largely unknown. Our study aimed to identify the potential function of CTBP1-DT in KIRC. RT-qPCR, Kaplan-Meier survival analysis, Cox regression analysis, and nomogram analysis were
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Effect of bromodomain PHD-finger transcription factor (BPTF) on trophoblast epithelial-to-mesenchymal transition Gene (IF 3.5) Pub Date : 2024-03-21 Linqing Pan, Fuquan Zhu, Aochen Yu, Chao Jia, Huaiyun Tang, Minglian Zhou, Mingrui Li, Shiwen Jiang, Juan Li, Yugui Cui, Lisha Tang
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Comprehensive identification and analysis of DUF640 genes associated with rice growth Gene (IF 3.5) Pub Date : 2024-03-21 Zhikai Wang, Ruihua Wang, Huanran Yuan, Fengfeng Fan, Shaoqing Li, Mingxing Cheng, Zhihong Tian
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Microarray analysis of tRNA-derived small RNA (tsRNA) in LPS-challenged macrophages treated with metformin Gene (IF 3.5) Pub Date : 2024-03-20 Huan Lin, Hongao Deng, Zhengying Jiang, Peng Hua, Shiqiang Hu, Haiyong Ao, Meiling Zhong, Mingzhuo Liu, Guanghua Guo
Metformin, a widely used anti-diabetic drug, has demonstrated its efficacy in addressing various inflammatory conditions. tRNA-derived small RNA (tsRNA), a novel type of small non-coding RNA, exhibits diverse regulatory functions and holds promise as both a diagnostic biomarker and a therapeutic target for various diseases. The purpose of this study is to investigate whether the abundance of tsRNAs
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Genome-wide analysis of LOG family genes in castor and RcLOG5 enhances drought, salt, and cold stress tolerance in Arabidopsis thaliana Gene (IF 3.5) Pub Date : 2024-03-20 Yanxiao Li, Guishuang Zhu, Haonan Sun, Dianjun Xiang, Chunlan Zhang, Zhigang Li, Peng Liu
The gene encoding the specific phosphohydrolase LONELY GUY (LOG) plays an important role in the activation of cytokinin and the stress response in plant cells. However, the role of genes in castor bean () has not been reported. In this study, we identified a total of nine members of the gene family in the castor bean genome and investigated the upregulated expression of the gene using transcriptome
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Association between polymorphisms and atopic dermatitis susceptibility: A systematic review and meta-analysis Gene (IF 3.5) Pub Date : 2024-03-19 Yunxia Huang, Wei Zhou, Shunan Liu, Dan Zeng, Weikang Zhou
Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease that is closely linked to genetic factors. Previous studies have revealed numerous single nucleotide polymorphisms (SNPs) that been related to susceptibility to AD; however, the results are conflicting. Therefore, a meta-analysis was conducted to assess the associations of these polymorphisms and AD risk. PubMed, Web of Science
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miRNA-27a-3p is involved in the plasticity of differentiated hepatocytes Gene (IF 3.5) Pub Date : 2024-03-17 Debora Salerno, Giovanna Peruzzi, Giuseppe Rubens Pascucci, Massimo Levrero, Laura Belloni, Natalia Pediconi
Epigenetic mechanisms, including DNA methylation, histone modifications, and chromatin remodeling, are highly involved in the regulation of hepatocyte viability, proliferation, and plasticity. We have previously demonstrated that repression of H3K27 methylation in differentiated hepatic HepaRG cells by treatment with GSK-J4, an inhibitor of JMJD3 and UTX H3K27 demethylase activity, changed their phenotype
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ChaC1 upregulation reflects poor prognosis in a variety of cancers: analysis of the major missense SNPs of ChaC1 as an aid to refining prognosis Gene (IF 3.5) Pub Date : 2024-03-17 Devraj Parande, Shradha Suyal, Anand K Bachhawat
The ChaC1 enzyme that catalyzes cytosolic glutathione degradation is highly upregulated in several cancers. In a systematic review of gene signature panels for cancer prognosis based on oxidative stress and ferroptosis genes, we observed that ChaC1 was found in panels in a wide variety of different cancers, with the upregulation correlating with poor prognosis. Since SNPs can have an impact on functionality
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Functional relevance of MMP2 promoter variants in gallbladder cancer: A case-control study in an Eastern Indian Population Gene (IF 3.5) Pub Date : 2024-03-17 Vinay Jeeyar, Shivaram Prasad Singh, Manjusha Dixit
Gallbladder cancer (GBC) is a prevalent and deadly form of bile duct cancer, associated with poor prognosis. This study aimed to investigate the genetic factors contributing to the high incidence of GBC in certain geographical regions, particularly in the Northern and Eastern parts of India. The present case-control study focused on MMP2, a gene involved in tumor progression and metastasis, as a potential
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Mitochondrial genes modulate the phenotypic expression of congenital scoliosis syndrome caused by mutations in the TBXT gene Gene (IF 3.5) Pub Date : 2024-03-16 Olfa Alila-Fersi, Amel Tej, Marwa Maalej, Marwa Kharrat, Lamia Boughamoura, Jihen Chouchen, Abdelaziz Tlili, Faiza Fakhfakh
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Establishment of virus-induced gene-silencing system in Juglans sigillata Dode and functional analysis of JsFLS2 and JsFLS4 Gene (IF 3.5) Pub Date : 2024-03-16 Yanyang Hong, Rong Wei, Chunxiang Li, Hu Cai, Erjuan Chen, Xuejun Pan, Wen'e Zhang
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Lianhua Qingwen exerts anti-liver cancer effects and synergistic efficacy with sorafenib through PI3K/AKT pathway: Integrating network pharmacology, molecular docking, and experimental validation Gene (IF 3.5) Pub Date : 2024-03-16 Jinrui Wei, Xuqi Zhao, Fuli Long, Kunpeng Tian, Lichuan Wu
Liver cancer is one of the most lethal malignancies and sorafenib resistance is the main treatment obstacle for patients with advanced liver cancer. Developing drugs that sensitize liver cancer patients to sorafenib is of great importance. Lianhua Qingwen (LHQW), a sort of Traditional Chinese Medicine (TCM) approved by the Chinese Food and Drug Administration (CFDA), is reported to exert synergistic
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Identification and validation of ferroptosis-related lncRNA signature in intervertebral disc degeneration Gene (IF 3.5) Pub Date : 2024-03-15 Penglei Cui, Tianyi Liu, Yueyang Sheng, Xinyu Wang, Qianqian Wang, Da He, Chengai Wu, Wei Tian
Low back pain influences people of every age and is one of the major contributors to the global cost of illness. Intervertebral disc degeneration (IVDD) is a major contributor to low back pain, but its pathogenesis is unknown. Recently, ferroptosis has been shown to have a substantial role in modulating IVDD progression. However, the function of ferroptosis-related long non-coding RNAs (lncRNAs) has
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Genetic features of patients with MPS type IIIB: Description of five pathogenic gene variations Gene (IF 3.5) Pub Date : 2024-03-15 Mahzad Nasir Shalal, Majid Aminzadeh, Alihossein Saberi, Reza Azizi Malmiri, Reza Aminzadeh, Pegah Ghandil
There are four distinct forms of Sanfilippo syndrome (MPS type III), each of which is an autosomal lysosomal storage disorder. These forms are caused by abnormalities in one of four lysosomal enzymes. This study aimed to identify possible genetic variants that contribute to Sanfilippo IIIB in 14 independent families in Southwest Iran. Patients were included if their clinical features and enzyme assay
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Comparative identification of WRKY transcription factors and transcriptional response to Ralstonia solanacearum in tomato Gene (IF 3.5) Pub Date : 2024-03-15 Deju Shui, Ji Sun, Zili Xiong, Shengmei Zhang, Jianlei Shi
In order to study the responses of tomato () WRKY TFs to bacterial wilt caused by , the most up-to-date genomes and transcriptional profiles were used to identify WRKY TFs in control and infected inbred lines. In total, 85 tomato WRKY TFs were identified and categorized into groups I, IIa + b, IIc, IId + e, and III. These WRKYs, especially those from group IIe, were mainly distributed at chromosome
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Identification of the ERF gene family of Mangifera indica and the defense response of MiERF4 to Xanthomonas campestris pv. mangiferaeindicae Gene (IF 3.5) Pub Date : 2024-03-15 Chen Lei, Zhiguo Dang, Min Zhu, Mengting Zhang, Huiliang Wang, Yeyuan Chen, He Zhang
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Targeting CAMK2N1/CAMK2 inhibits invasion, migration and angiogenesis of non-small cell lung cancer by promoting autophagy and apoptosis via AKT/mTOR signaling pathway Gene (IF 3.5) Pub Date : 2024-03-14 Qiang Wang, Chao Zhang, Hai Jiang, Weiyang He
Deregulation of calcium/calmodulin-dependent protein kinase II (CAMK2) inhibitor 1 (CAMK2N1) has been reported to be associated with the development of several malignancies. To date, there have been few studies on the role of CAMK2N1 in lung cancer. This study aimed to investigate the relationship between CAMK2N1 and the progression of non-small cell lung cancer (NSCLC). Methodological quality was
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Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition Gene (IF 3.5) Pub Date : 2024-03-14 Yongyuan Zheng, Weibing Li, Yansong Huang, Hongqiu Cheng
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Identification of suitable reference genes for RT-qPCR studies in human parathyroid tissue glandular cells Gene (IF 3.5) Pub Date : 2024-03-14 Beyza Goncu
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SARS-CoV-2 and UPS with potentials for therapeutic interventions Gene (IF 3.5) Pub Date : 2024-03-14 Jannatul Ferdoush, Rizwaan Abdul Kadir, Selin Simay Kaplanoglu, Morgan Osborn
The Ubiquitin proteasome system (UPS), an essential eukaryotic/host/cellular post-translational modification (PTM), plays a critical role in the regulation of diverse cellular functions including regulation of protein stability, immune signaling, antiviral activity, as well as virus replication. Although UPS regulation of viral proteins may be utilized by the host as a defense mechanism to invade viruses
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Meta-analysis of Circulatory mitomiRs in stress Response: Unveiling the significance of miR-34a and miR-146a Gene (IF 3.5) Pub Date : 2024-03-14 Arpan Chattopadhyay, Harshita Tak, Jivanage Anirudh, B. Hemanth Naick
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A rare homozygous mutation in the YARS2 gene presents with hypertrophic cardiomyopathy, lactic acidosis and anemia in a Chinese infant Gene (IF 3.5) Pub Date : 2024-03-13 Dandan Xiang, Kangkang Xu, Mei Chen, Zhongman Zhang, Ningning Sun, Yuying Qi, Jie Lu, Chunli Wang, Shiwei Yang
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Revisiting the role and mechanism of ELF3 in circadian clock modulation Gene (IF 3.5) Pub Date : 2024-03-13 Xingzun Zhu, Hongtao Wang