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Changes in brain proteasome dynamics associated with aging Genes Cells (IF 2.1) Pub Date : 2024-03-26 Nodoka Nago, Shigeo Murata, Keiji Tanaka, Nobuyuki Tanahashi
In the nervous system, proteasomes are important for proteolysis and cellular homeostasis of neurons and glial cells and for brain health. Proteasome function declines with age in many tissues, including the nervous system, and this decline affects many of the nervous system processes important to brain health and may be related to age‐related cognitive decline. Therefore, we analyzed the factors that
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Long‐term sorbitol consumption affects the hippocampus and alters cognitive function in aged mice Genes Cells (IF 2.1) Pub Date : 2024-03-12 Haruna Yokoi, Jingshu Wang, Yoriko Ikuyo, Mitsuyoshi Yamada, Yosuke Shikama, Masae Furukawa, Kenji Matsushita
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Staphylococcal superantigen‐like protein 3 triggers murine mast cell adhesion by binding to CD43 and augments mast cell activation Genes Cells (IF 2.1) Pub Date : 2024-03-08 Sae Kawano, Chisaki Noda, Saotomo Itoh, Ayaka Urabe, Chifumi Fujii, Isamu Ogawa, Ryo Suzuki, Shigeaki Hida
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Left–right Myosin‐Is, Myosin1C, and Myosin1D exhibit distinct single molecule behaviors on the plasma membrane of Drosophila macrophages Genes Cells (IF 2.1) Pub Date : 2024-03-08 Sosuke Utsunomiya, Kazutoshi Takebayashi, Asuka Yamaguchi, Takeshi Sasamura, Mikiko Inaki, Masahiro Ueda, Kenji Matsuno
Left–right (LR) asymmetry is crucial for animal development, particularly in Drosophila where LR‐asymmetric morphogenesis of organs hinges on cellular‐level chirality, termed cell chirality. In this species, two class I myosins, Myosin1D (Myo1D), and Myosin1C (Myo1C), respectively determine dextral (wild type) and sinistral (mirror image) cell chirality. Previous studies demonstrated Myo1D's ability
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Issue Information Genes Cells (IF 2.1) Pub Date : 2024-03-04
Front cover: This is an ornamental tool called an ‘inro’ used to carry medicines in the Edo period. On the surface of this inro, the structure of N1‐methyl‐pseudouridine (N1mΨ), the key to the development of the mRNA vaccine against COVID‐19, is schematically depicted with plum buds (oxygen atoms) and branches, using the maki‐e lacquer decoration technique. Coronavirus particles are depicted on the
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Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heterochromatic targeting module Genes Cells (IF 2.1) Pub Date : 2024-02-26 Masaru Nakao, Yuko Sato, Arisa Aizawa, Hiroshi Kimura
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Self‐recognition through Dectin‐1 exacerbates liver inflammation Genes Cells (IF 2.1) Pub Date : 2024-02-22 Shota Torigoe, Douglas W. Lowman, Toshihiko Sugiki, David L. Williams, Sho Yamasaki
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Premature gray hair development in the interbrow region owing to the loss of maxillary first molars in young mice Genes Cells (IF 2.1) Pub Date : 2024-02-21 Masae Furukawa, Haruna Yokoi, Jingshu Wang, Yoriko Ikuyo, Hirobumi Tada, Mitsuyoshi Yamada, Yosuke Shikama, Kenji Matsushita
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Isoliquiritigenin inhibits NLRP3 inflammasome activation with CAPS mutations by suppressing caspase-1 activation and mutated NLRP3 aggregation Genes Cells (IF 2.1) Pub Date : 2024-02-17 Fumitake Usui-Kawanishi, Koudai Kani, Tadayoshi Karasawa, Hiroe Honda, Nobuyuki Takayama, Masafumi Takahashi, Kiyoshi Takatsu, Yoshinori Nagai
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Cathepsin L prevents the accumulation of alpha-synuclein fibrils in the cell Genes Cells (IF 2.1) Pub Date : 2024-02-17 Ayumi Matsuki, Yoshihisa Watanabe, Sho Hashimoto, Atsushi Hoshino, Satoaki Matoba
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Analysis of the responsiveness to antiandrogens in multiple breast cancer cell lines Genes Cells (IF 2.1) Pub Date : 2024-02-17 Yuka Kuroiwa, Kagenori Ito, Jun Nakayama, Kentaro Semba, Yusuke Yamamoto
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Roles of linker region flanked by transmembrane and peptidoglycan binding region of PomB in energy conversion of the Vibrio flagellar motor Genes Cells (IF 2.1) Pub Date : 2024-02-14 Yusuke Miyamura, Tatsuro Nishikino, Hiroaki Koiwa, Michio Homma, Seiji Kojima
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CdsA, a CDP-diacylglycerol synthase involved in phospholipid and glycolipid MPIase biosynthesis, possesses multiple initiation codons Genes Cells (IF 2.1) Pub Date : 2024-02-13 Runa Hikage, Yusei Sekiya, Katsuhiro Sawasato, Ken-ichi Nishiyama
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Publishing in the Open Access and Open Science era Genes Cells (IF 2.1) Pub Date : 2024-02-13 Masanori Arita, Bernd Pulverer, Tadashi Uemura, Chisako Sakuma, Shigeo Hayashi
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C9orf10/Ossa regulates the bone metastasis of established lung adenocarcinoma cell subline H322L-BO4 in a mouse model Genes Cells (IF 2.1) Pub Date : 2024-02-10 Takamasa Uekita, Reiko Yagi, Tohru Ichimura, Ryuichi Sakai
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The anti-inflammatory effect of metformin: The molecular targets Genes Cells (IF 2.1) Pub Date : 2024-02-04 Natsumi Sakata
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Transcriptional features of low-grade neuroepithelial tumors with the BRAF V600E mutation associated with epileptogenicity Genes Cells (IF 2.1) Pub Date : 2024-01-25 Keiya Iijima, Kanako Komatsu, Satoshi Miyashita, Kyoka Suyama, Kumiko Murayama, Koichi Hashizume, Nao K. Tabe, Hajime Miyata, Masaki Iwasaki, Shinichiro Taya, Mikio Hoshino
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Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation Genes Cells (IF 2.1) Pub Date : 2024-01-21 Shinichiro Yamamoto, Naoto Kiyatake, Akihiro Kaneko, Masanao Shimamura, Takashi Yoshida, Shunichi Shimizu
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The optimized priming effect of FGF-1 and FGF-2 enhances preadipocyte lineage commitment in human adipose-derived mesenchymal stem cells Genes Cells (IF 2.1) Pub Date : 2024-01-22 Tanakorn Tarapongpun, Nattawat Onlamoon, Kouichi Tabu, Suebwong Chuthapisith, Tetsuya Taga
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GTP-dependent regulation of heterochromatin fluctuations at subtelomeric regions in Saccharomyces cerevisiae Genes Cells (IF 2.1) Pub Date : 2024-01-16 Takahito Ayano, Takuma Yokosawa, Masaya Oki
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Extracellular α-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells Genes Cells (IF 2.1) Pub Date : 2024-01-01 Susumu Nishida, Shubi Ambwene Matovelo, Taketoshi Kajimoto, Shun-ichi Nakamura, Taro Okada
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Metastatic potentials classified with hypoxia-inducible factor 1 downstream genes in pan-cancer cell lines Genes Cells (IF 2.1) Pub Date : 2023-12-29 Kazuya Nakamichi, Yusuke Yamamoto, Kentaro Semba, Jun Nakayama
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Generation of inducible mitophagy mice Genes Cells (IF 2.1) Pub Date : 2023-12-22 Toshiyuki Nishiji, Atsushi Hoshino, Yuki Uchio, Satoaki Matoba
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Insertion sequence excision is enhanced by a protein that catalyzes branch migration and promotes microhomology-mediated end joining Genes Cells (IF 2.1) Pub Date : 2023-12-14 Ren Kishino, Takashi Saito, Shuntaro Muto, Yuzuka Tomita, Yasuhiko Sekine
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Acidic growth conditions stabilize the ribosomal RNA gene cluster and extend lifespan through noncoding transcription repression Genes Cells (IF 2.1) Pub Date : 2023-12-08 Yo Hasegawa, Hiroyuki Ooka, Tsuyoshi Wakatsuki, Mariko Sasaki, Ayumi Yamamoto, Takehiko Kobayashi
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CD271 promotes proliferation and migration in bladder cancer Genes Cells (IF 2.1) Pub Date : 2023-11-28 Shingo Myoen, Mai Mochizuki, Rie Shibuya-Takahashi, Haruna Fujimori, Norihisa Shindo, Kazunori Yamaguchi, Jun Yasuda, Jiro Abe, Takayuki Imai, Ikuro Sato, Hisanobu Adachi, Sadafumi Kawamura, Akihiro Ito, Keiichi Tamai
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IMPDH2 forms spots at branching sites and distal ends of astrocyte stem processes Genes Cells (IF 2.1) Pub Date : 2023-11-27 Saori Toyoda, Takehisa Handa, Huang Yong, Hidehiko Takahashi, Hiroki Shiwaku
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Brain-derived neurotrophic factor (BDNF) downregulates mRNA levels of suppressor of cancer cell invasion (SCAI) variants in cortical neurons Genes Cells (IF 2.1) Pub Date : 2023-11-27 Daisuke Ihara, Miho Mizukoshi, Akiko Tabuchi
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Visualization of the landscape of the read alignment shape of ATAC-seq data using Hellinger distance metric Genes Cells (IF 2.1) Pub Date : 2023-11-21 Jian Hao Cheng, Cheng Zheng, Ryo Yamada, Daigo Okada
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Hypoxia stabilizes the H2O2-producing oxidase Nox4 in cardiomyocytes via suppressing autophagy-related lysosomal degradation Genes Cells (IF 2.1) Pub Date : 2023-11-20 Shogo Matsunaga, Akira Kohda, Sachiko Kamakura, Junya Hayase, Kei Miyano, Akira Shiose, Hideki Sumimoto
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Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I Genes Cells (IF 2.1) Pub Date : 2023-11-20 Hiromichi Okuma, Yumiko Saijo-Hamano, Hiroshi Yamada, Aalaa Alrahman Sherif, Emi Hashizaki, Naoki Sakai, Takaaki Kato, Tsuyoshi Imasaki, Satoshi Kikkawa, Eriko Nitta, Miwa Sasai, Tadashi Abe, Fuminori Sugihara, Yoshimasa Maniwa, Hidetaka Kosako, Kohji Takei, Daron M. Standley, Masahiro Yamamoto, Ryo Nitta
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DNA double-strand breaks regulate the cleavage-independent release of Rec8-cohesin during yeast meiosis Genes Cells (IF 2.1) Pub Date : 2023-11-15 Ghanim Fajish, Kiran Challa, Sagar Salim, Ajith VP, Stephen Mwaniki, Ruihao Zhang, Yurika Fujita, Masaru Ito, Koodali T. Nishant, Akira Shinohara
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Overexpression of JNK-associated leucine zipper protein induces chromosomal instability through interaction with dynein light intermediate chain 1 Genes Cells (IF 2.1) Pub Date : 2023-11-14 Ryusuke Suzuki, Masato T. Kanemaki, Takeshi Suzuki, Katsuji Yoshioka
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The PKM2 inhibitor shikonin enhances piceatannol-induced apoptosis of glyoxalase I-dependent cancer cells Genes Cells (IF 2.1) Pub Date : 2023-11-14 Manami Inoue, Yuki Nakagawa, Miku Azuma, Haruka Akahane, Ryusei Chimori, Yasunari Mano, Ryoko Takasawa
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CD41+ extracellular vesicles produced by avian thrombocytes contain microRNAs Genes Cells (IF 2.1) Pub Date : 2023-11-05 Kenkichi Sugimoto, Takamasa Nishikawa, Toshie Sugiyama
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T-cell receptor repertoire analysis of CD4-positive T cells from blood and an affected organ in an autoimmune mouse model Genes Cells (IF 2.1) Pub Date : 2023-11-01 Tatsuya Ishikawa, Kenta Horie, Yuki Takakura, Houko Ohki, Yuya Maruyama, Mio Hayama, Maki Miyauchi, Takahisa Miyao, Naho Hagiwara, Tetsuya J. Kobayashi, Nobuko Akiyama, Taishin Akiyama
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Intraperitoneal administration of mouse kisspeptin-10 to mice during estrus stage induces pseudopregnancy Genes Cells (IF 2.1) Pub Date : 2023-10-27 Daisuke Mashiko, Mikiko Tokoro, Tatsuma Yao, Kazuo Yamagata
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Possibilities of skin coat color-dependent risks and risk factors of squamous cell carcinoma and deafness of domestic cats inferred via RNA-seq data Genes Cells (IF 2.1) Pub Date : 2023-10-21 Akinori Awazu, Daigo Takemoto, Kaichi Watanabe, Naoaki Sakamoto
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Effects of lipoprotein nanoparticles' composition and size on their internalization in plant and mammalian cells Genes Cells (IF 2.1) Pub Date : 2023-10-18 Ryosuke Fukuda, Misaki Tani, Shiori Shibukawa, Tomohiro Nobeyama, Taiji Nomura, Yasuo Kato, Tatsuya Murakami
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Dynamics of actomyosin filaments in the contractile ring revealed by ultrastructural analysis Genes Cells (IF 2.1) Pub Date : 2023-10-16 Takeru Arima, Keisuke Okita, Shigehiko Yumura
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Leukemia inhibitory factor shortens primary cilia by upregulating C-C motif chemokine 2 in human neural stem/progenitor cells Genes Cells (IF 2.1) Pub Date : 2023-10-14 Hisashi Takahashi, Takahiro Fujimoto, Takeshi Yaoi, Shinji Fushiki, Kyoko Itoh
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Dilp8 and its candidate receptor, Drl, are involved in the transdetermination of the Drosophila imaginal disc Genes Cells (IF 2.1) Pub Date : 2023-10-10 Kazuya Nemoto, Keita Masuko, Naoyuki Fuse, Shoichiro Kurata
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The 33rd International Conference on Arabidopsis Research (ICAR2023) Genes Cells (IF 2.1) Pub Date : 2023-10-07 Minoru Ueda, Tetsuya Higashiyama, Keiko Sugimoto, Keiichi Mochida, Keiji Nakajima, Makoto Hayashi, Masanori Okamoto, Yuki Nakamura, Motoaki Seki
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The role of Zfp352 in the regulation of transient expression of 2-cell specific genes in mouse embryonic stem cells Genes Cells (IF 2.1) Pub Date : 2023-10-01 Lusubilo Mwalilino, Mariko Yamane, Kei-ichiro Ishiguro, Shingo Usuki, Mitsuhiro Endoh, Hitoshi Niwa
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Isolation of planarian viable cells using fluorescence-activated cell sorting for advancing single-cell transcriptome analysis Genes Cells (IF 2.1) Pub Date : 2023-09-18 Yoshihito Kuroki, Kiyokazu Agata
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Pkd2, mutations linking to autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates calcium signaling in fission yeast Genes Cells (IF 2.1) Pub Date : 2023-09-18 Takayuki Koyano, Takahiro Fujimoto, Kaori Onishi, Makoto Matsuyama, Masaki Fukushima, Kazunori Kume
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Yeast Tor complex 1 phosphorylates eIF4E-binding protein, Caf20 Genes Cells (IF 2.1) Pub Date : 2023-09-12 Yoshiaki Kamada, Ryoko Ando, Shingo Izawa, Akira Matsuura
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Lumicrine signaling: Extracellular regulation of sperm maturation in the male reproductive tract lumen Genes Cells (IF 2.1) Pub Date : 2023-09-11 Daiji Kiyozumi
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Wnt10b knockdown promotes UCP1 expression in brown adipose tissue in mice Genes Cells (IF 2.1) Pub Date : 2023-09-10 Yanxin Jia, Yan Liu, Shuang Liu, Yaxin Chang, Longfei Xu, Haifang Li
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Issue Information Genes Cells (IF 2.1) Pub Date : 2023-09-06
Front cover: A full moon rises over the torii gate of Itsukushima Shrine in Miyajima (Hiroshima Prefecture), with countless reflections on the waves. Upon closer inspection, the numerous moon figures seen on the waves are actually cells of the fission yeast Schizosaccharomyces pombe. In addition to cells undergoing vegetative growth, cells in the process of sexual reproduction (conjugation, first and
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Differential dependence on microbiota of IL-23/IL-22-dependent gene expression between the small- and large-intestinal epithelia Genes Cells (IF 2.1) Pub Date : 2023-09-07 Ayaka Nakatani, Ryu Okumura, Airi Ishibashi, Shota Okamoto, Kei Sakaki, Yuki Ito, Daisuke Okuzaki, Hidenori Inohara, Kiyoshi Takeda
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Validity of the cell-extracted proteome as a substrate pool for exploring phosphorylation motifs of kinases Genes Cells (IF 2.1) Pub Date : 2023-09-02 Tomoya Niinae, Naoyuki Sugiyama, Yasushi Ishihama
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Daidara: A gigantic Gypsy LTR retrotransposon lineage in the springtail Allacma fusca genome Genes Cells (IF 2.1) Pub Date : 2023-08-31 Kenji K. Kojima
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DHX36 maintains genomic integrity by unwinding G-quadruplexes Genes Cells (IF 2.1) Pub Date : 2023-08-26 Ayaka Mizumoto, Yuta Yokoyama, Tomoichiro Miyoshi, Masahiro Takikawa, Fuyuki Ishikawa, Mahito Sadaie
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Ectopic expression of matrix metalloproteinases and filopodia extension via JNK activation are involved in the invasion of blood tumor cells in Drosophila mxc mutant Genes Cells (IF 2.1) Pub Date : 2023-08-24 Kazuki Takarada, Juri Kinoshita, Yoshihiro H. Inoue
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Cdc7 kinase is required for postnatal brain development Genes Cells (IF 2.1) Pub Date : 2023-08-16 Karin Hori, Satoshi Yamazaki, Chiaki Ohtaka-Maruyama, Tomio Ono, Tomohiro Iguchi, Hisao Masai