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GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-29 Yani Wang,Danjing Hu,Linyan Wan,Shuhui Yang,Song Liu,Zixi Wang,Jie Li,Jia Li,Zhoude Zheng,Chongsheng Cheng,Yanan Wang,Hanghang Wang,Xinlun Tian,Wenhui Chen,Shanqing Li,Ji Zhang,Xiaojun Zha,Jingyu Chen,Hongbing Zhang,Kai-Feng Xu
Idiopathic pulmonary fibrosis (IPF) is a lethal progressive disease with elusive molecular mechanisms and limited therapeutic methods. Aberrant activation of fibroblasts is a central hallmark of lung fibrosis. Here we report that Golgi membrane protein 1 (GOLM1, also known as GP73 or GOLPH2), was elevated in both lungs of patients with pulmonary fibrosis and bleomycin (BLM)-induced pulmonary fibrotic
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Rieske Iron-Sulfur Protein Mediates Pulmonary Hypertension Following Nicotine/Hypoxia Co-Exposure. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-29 Lillian N Truong,Ed Wilson Santos,Yun-Min Zheng,Yong-Xiao Wang
The high mortality of chronic obstructive pulmonary disease (COPD) patients may occur due to pulmonary hypertension (PH). These diseases are highly associated with cigarette smoke (CS) and its key component nicotine use. Here, we created a novel animal model of PH using nicotine (or CS) and hypoxia (N/H) co-exposure. This never-reported model showed a significant early-onset pulmonary vasoremodeling
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Epigenetic Reprogramming Drives Epithelial Disruption in COPD. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-17 Bonnie H Yeung-Luk,Ara Wally,Carter Swaby,Sofia Jauregui,Esther Lee,Rachel Zhang,Daniel Chen,Sean H Luk,Nisha Upadya,Ethan Tieng,Kai Wilmsen,Ethan Sherman,Dheeksha Sudhakar,Matthew Luk,Abhishek Kumar Shrivastav,Shuo Cao,Baishakhi Ghosh,Stephanie A Christenson,Yvonne J Huang,Victor E Ortega,Shyam Biswal,Wan-Yee Tang,Venkataramana K Sidhaye
Chronic obstructive pulmonary disease (COPD) remains a major public health challenge that contributes greatly to mortality and morbidity worldwide. Although it has long been recognized that the epithelium is altered in COPD, there has been little focus on targeting it to modify the disease course. Therefore, mechanisms that disrupt epithelial cell function in COPD patients are poorly understood. In
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InfluenZing Lung Fibrosis: Reinforcing Endothelial Surface Expression of S1PR1 to Attenuate Post-ARDS Lung Remodeling. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-15 Georgios Kiliaris,Elie El Agha
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Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-07 Patricia L Brazee,Andreane Cartier,Andrew Kuo,Alexis M Haring,Trong Nguyen,Lida P Hariri,Jason W Griffith,Timothy Hla,Benjamin D Medoff,Rachel S Knipe
Respiratory viral infections are frequent causes of acute respiratory distress syndrome (ARDS), a disabling condition with a mortality of up to 46%. The pulmonary endothelium plays an important role in the development of ARDS as well as the pathogenesis of pulmonary fibrosis; however, the therapeutic potential to modulate endothelial-dependent signaling to prevent deleterious consequences has not been
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Standardized Digital Method for Histological Evaluation of Experimental Acute Lung Injury. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Camilla Predella,Daniela Iezza,Michael L Miller,Theresa Swayne,Anjali Saqi,N Valerio Dorrello
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Boosting the Exhausted Vasculature-SIRT3 (to the) Rescue. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Senka Ljubojevic-Holzer,Slaven Crnkovic
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Does Chronic Obstructive Pulmonary Disease Originate from Different Cell Types? Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Yohannes Tesfaigzi,Jeffrey L Curtis,Irina Petrache,Francesca Polverino,Farrah Kheradmand,Ian M Adcock,Stephen I Rennard
The onset of chronic obstructive pulmonary disease (COPD) is heterogeneous, and current approaches to define distinct disease phenotypes are lacking. In addition to clinical methodologies, subtyping COPD has also been challenged by the reliance on human lung samples from late-stage diseases. Different COPD phenotypes may be initiated from the susceptibility of different cell types to cigarette smoke
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ANT1 and the SASP: Beyond the Bioenergetic Void. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Sunad Rangarajan
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NF-κB Signaling in Congenital Diaphragmatic Hernia: A Potential Therapeutic Strategy? Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Viral G Jain,Namasivayam Ambalavanan
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Overactivated Epithelial NF-κB Disrupts Lung Development in Congenital Diaphragmatic Hernia. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Florentine Dylong,Jan Riedel,Gaurang M Amonkar,Nicole Peukert,Paula Lieckfeldt,Katinka Sturm,Benedikt Höxter,Wai Hei Tse,Yuichiro Miyake,Maria Moormann,Lena Marie Bode,Steffi Mayer,Richard Keijzer,Martin Lacher,Xingbin Ai,Jan-Hendrik Gosemann,Richard Wagner
Abnormal lung development is the main cause of morbidity and mortality in neonates with congenital diaphragmatic hernia (CDH), a common birth defect (1:2,500) of largely unknown pathobiology. Recent studies discovered that inflammatory processes, and specifically NF-κB-associated pathways, are enriched in human and experimental CDH. However, the molecular signaling of NF-κB in abnormal CDH lung development
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Putting a Novel Emphysema Treatment on the SMAP. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Dongqi Xing,J Michael Wells
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Evaluating Novel Protein Phosphatase 2A Activators as Therapeutics for Emphysema. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Brian Soto,Huma Ahmed,Meshach Pillai,Sangmi S Park,Magdalena Ploszaj,Joshua Reece,Harsha Taluru,Dylan Bobrow,Howard Yu,Pascale Lafortune,Bakr Jundi,Louis Costanzo,Abdoulaye J Dabo,Robert F Foronjy,Christian Mueller,Michael Ohlmeyer,Patrick Geraghty
The activity of PP2A (protein phosphatase 2A), a serine-threonine phosphatase, is reduced by chronic cigarette smoke (SM) exposure and α-1 antitrypsin (AAT) deficiency, and chemical activation of PP2A reduces the loss of lung function in SM-exposed mice. However, the previously studied PP2A-activator tricyclic sulfonamide compound DBK-1154 has low stability to oxidative metabolism, resulting in fast
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Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Ajay P Nayak,Elham Javed,Dominic R Villalba,Yinna Wang,Henry P Morelli,Sushrut D Shah,Nicholas Kim,Rennolds S Ostrom,Reynold A Panettieri,Steven S An,Dale D Tang,Raymond B Penn
Prostaglandin E2 imparts diverse physiological effects on multiple airway cells through its actions on four distinct E-type prostanoid (EP) receptor subtypes (EP1-EP4). Gs-coupled EP2 and EP4 receptors are expressed on airway smooth muscle (ASM), yet their capacity to regulate the ASM contractile state remains subject to debate. We used EP2 and EP4 subtype-specific agonists (ONO-259 and ONO-329, respectively)
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Modulating the m6A Modified Transcription Factor GATA6 Impacts Epithelial Cytokines in Acute Lung Injury. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Ai Jin,Li Li,Yan Zhao,Mei Li,Shanshan Zhang,Jian Chen,Yuwen Li,Lei Huang,Hui Ren,Shemin Lu,Xiaojun Yang,Qingzhu Sun
The methylation of m6A (N6-position of adenosine) has been found to be associated with inflammatory response. We hypothesize that m6A modification plays a role in the inflammation of airway epithelial cells during lung inflammation. However, the precise changes and functions of m6A modification in airway epithelial cells in acute lung injury (ALI) are not well understood. Here we report that METTL3
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When It Comes to COVID-19, Inflammation Is All the RAGE. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Orestis Katsoulis,Rui Guo,Aran Singanayagam
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RAGE Is a Receptor for SARS-CoV-2 N Protein and Mediates N Protein-induced Acute Lung Injury. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Jie Xia,Jiangmei Wang,Liyang Ying,Ruoqiong Huang,Kai Zhang,Ruoyang Zhang,Wenqi Tang,Qi Xu,Dengming Lai,Yan Zhang,Yaoqin Hu,Xiaodie Zhang,Ruoxi Zang,Jiajie Fan,Qiang Shu,Jianguo Xu
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein (N-protein) increases early in body fluids during infection and has recently been identified as a direct inducer for lung injury. However, the signal mechanism of N-protein in the lung inflammatory response remains poorly understood. The goal of this study was to determine whether RAGE (receptor for advanced glycation
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P300/CBP Regulates HIF-1 Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-24 Ning Wang,Xiaoyu Su,David Sams,Nanduri R Prabhakar,Jayasri Nanduri
Obstructive sleep apnea (OSA), a widespread breathing disorder, leads to intermittent hypoxia (IH). OSA patients and IH-treated rodents exhibit heightened sympathetic nerve activity and hypertension. Previous studies reported transcriptional activation of NADPH oxidases (Nox) by hypoxia-inducible factor-1 (HIF-1) contribute to autonomic dysfunction in IH treated rodents. Lysine acetylation, regulated
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Cellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-24 Xigang Jing,Shuang Jia,Maggie Teng,Billy W Day,Adeleye J Afolayan,Jason A Jarzembowski,Chien-Wei Lin,Martin J Hessner,Kirkwood A Pritchard,Stephen Naylor,G Ganesh Konduri,Ru-Jeng Teng
Oxidative stress (OS), inflammation, and endoplasmic reticulum (ER) stress sequentially occur in bronchopulmonary dysplasia (BPD), and all result in DNA damage. When DNA damage becomes irreparable, tumor suppressors increase, followed by apoptosis or senescence. Although cellular senescence contributes to wound healing, its persistence inhibits growth. Therefore, we hypothesized that cellular senescence
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Pleural Fibrosis: Now That's What mTORC(ing) About. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-03 Steven E Mutsaers,Vera P Krymskaya
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Implementation of Recommendations for Features and Measurements of Experimental Acute Lung Injury. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-01 Dwi Cahyo Budi Setiawan,Szandor Simmons,Laura Michalick,Wolfgang M Kuebler
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Got Oxygen? Studies on Mesenchymal Cell Hypoxia Inducible Factor-1α in Lung Development. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-01 Reece P Stevens,Ji Young Lee,Natalie Bauer,Troy Stevens
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Reclaiming the Balance: Blocking Glutamine Uptake to Restrain Pulmonary Fibrosis. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-01 Gang Liu,Ross Summer
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The Journal Moves Forward: Passing the Torch to the Next Generation. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Paul T Schumacker
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Making Mountains Out of Mole Hills: The Role of CD36 in Oxidized Phospholipid-Driven Lung Injury. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-09-25 Michael J Yaeger,Saame Raza Shaikh,Kymberly M Gowdy
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LKB1 Regulates PH Endothelial Cell Mitochondria: Another Layer of the Pulmonary Vascular Onion? Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-09-22 Aaron W Trammell,C Michael Hart
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Prenatal FGFR2 Signaling via PI3K/AKT Specifies the PDGFRA+ Myofibroblast. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-09-21 Matthew R Riccetti,Jenna Green,Thomas J Taylor,Anne-Karina T Perl
It is well known that Fibroblast Growth Factor Receptor 2 (FGFR2) signaling is critical for proper lung development. Recent studies demonstrate that epithelial FGFR2 signaling during the saccular phase of lung development (sacculation) regulates AT1 and AT2 cell differentiation. During sacculation, Platelet-Derived Growth Factor Receptor Alpha-positive (PDGFRA+) lung fibroblasts exist as three functional
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Amphipathic Helical Peptide L37-pA Protects Against Lung Vascular Endothelial Dysfunction Caused by Truncated Oxidized Phospholipids via Antagonism with CD36 Receptor. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-09-19 Pratap Karki,Yue Li,Chen-Ou Zhang,Yunbo Ke,Kamoltip Promnares,Anna A Birukova,Thomas L Eggerman,Alexander V Bocharov,Konstantin G Birukov
Generation of bioactive truncated oxidized phospholipids (Tr-OxPLs) from oxidation of cell membrane or circulating lipoproteins is a common feature of various pathological states. Scavenger receptor CD36 is involved in lipid transport and acts as a ligand for Tr-OxPLs. Interestingly, both Tr-OxPLs and CD36 are involved in endothelial dysfunction-derived acute lung injury but precise mechanistic connections
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Mitochondria Derived Vesicle Packaging as a Novel Therapeutic Mechanism in Pulmonary Hypertension. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-09-15 Qiang Zhao,Zhixue Liu,Ping Song,Zuyi Yuan,Ming-Hui Zou
Increasing evidence suggests that mitochondrial dysfunction in pulmonary endothelial cells (ECs) plays a causative role in the initiation and progression of pulmonary hypertension (PH); how mitochondria become dysfunctional in PH remains elusive. Mitochondria-derived vesicles (MDVs) are small subcellular vesicles that excise from mitochondria. Whether or not MDVs deregulation causes mitochondrial dysfunction
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Back to the Eosinophil: Resolvin Spatiotemporal Regulation. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Chantal Donovan,Jessica L Barnes,Richard Y Kim
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Can Airway Monocytes from Premature Infants Teach Us about Macrophage Differentiation in the Lungs? Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Andrew D Prigge,Bria M Coates
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Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-09-12 Kamakshi Bankoti,Wei Wang,Gaurang M Amonkar,Linjie Xiong,Jessica E Shui,Caiqi Zhao,Eric Van,Chimwemwe Mwase,Jin-Ah Park,Hongmei Mou,Yinshan Fang,Jianwen Que,Yan Bai,Paul H Lerou,Xingbin Ai
Airway basal stem cells (BSCs) play a critical role in epithelial regeneration. Whether COVID-19 (CoV19) affects the function of BSCs is unknown. Here, we derived BSC lines from CoV19 patients using tracheal aspirates (TA) to circumvent biosafety concerns of live cell derivation. We show that BSCs derived from TA of control patients are bona fide bronchial BSCs. TA BSCs from CoV19 patients tested negative
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Reactive Oxygen Species Behaving Badly: Oxidized Phosphatidylcholines Corrupt Ca2+ Signaling in Airway Smooth Muscle. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Deepak A Deshpande,Raymond B Penn
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The Importance of "Negative" Results: Lipid Lessons in Coronavirus Biology. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Sarah R Leist,Jason R Mock
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Inhibition of the Cellular Deubiquitinase UCHL1 Suppresses SARS-CoV-2 Replication. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-09-01 Bharathiraja Subramaniyan,Jason L Larabee,Manish Bodas,Andrew R Moore,Anthony W G Burgett,James F Papin,Matthew S Walters
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Ionocyte-Specific Regulation of Cystic Fibrosis Transmembrane Conductance Regulator. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-09-01 Yukiko Sato,Dusik Kim,Mark J Turner,Yishan Luo,Syeda Sadaf Zehra Zaidi,David Y Thomas,John W Hanrahan
CFTR (cystic fibrosis transmembrane conductance regulator) is a tightly regulated anion channel that mediates chloride and bicarbonate conductance in many epithelia and in other tissues, but whether its regulation varies depending on the cell type has not been investigated. Epithelial CFTR expression is highest in rare cells called ionocytes. We studied CFTR regulation in control and ionocyte-enriched
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Single-Cell Profiling of Premature Neonate Airways Reveals a Continuum of Myeloid Differentiation. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Holly Welfley,Ranjit Kylat,Nahla Zaghloul,Marilyn Halonen,Fernando D Martinez,Mohamed Ahmed,Darren A Cusanovich
Single-cell genomic technologies hold great potential to advance our understanding of lung development and disease. A major limitation lies in accessing intact cells from primary lung tissues for profiling human airway health. Sampling methods such as endotracheal aspiration that are compatible with clinical interventions could enable longitudinal studies, the enrollment of large cohorts, and the development
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Calpain Promotes LPS-induced Lung Endothelial Barrier Dysfunction via Cleavage of Talin. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Linjie Song,Xiaofan Shi,Laszlo Kovacs,Weihong Han,Joseph John,Scott A Barman,Zheng Dong,Rudolf Lucas,David J R Fulton,Alexander D Verin,Yunchao Su
Acute lung injury (ALI) is characterized by lung vascular endothelial cell (EC) barrier compromise resulting in increased endothelial permeability and pulmonary edema. The infection of gram-negative bacteria that produce toxins like LPS is one of the major causes of ALI. LPS activates Toll-like receptor 4, leading to cytoskeleton reorganization, resulting in lung endothelial barrier disruption and
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The mTORC2/SGK1/NDRG1 Signaling Axis Is Critical for Mesomesenchymal Transition of Pleural Mesothelial Cells and the Progression of Pleural Fibrosis. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-08-22 Shiva Keshava,Shuzi Owens,Wenyi Qin,Ann Jeffers,Perpetual Kyei,Satoshi Komatsu,Joshua Kleam,Mitsuo Ikebe,Steven Idell,Torry A Tucker
Progressive lung scarring due to persistent pleural organization often results in pleural fibrosis (PF). This process affects patients with complicated parapneumonic pleural effusions, empyema, and other pleural diseases prone to loculation. In PF, pleural mesothelial cells undergo mesomesenchymal transition (MesoMT) to become profibrotic, characterized by increased expression of α-smooth muscle actin
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Upper Respiratory Tract OC43 Infection Model for Investigating Airway Immune-Modifying Therapies. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Jason L N Girkin,Nathan E Bryant,Su-Ling Loo,Alan Hsu,Amama Kanwal,Teresa C Williams,Steven Maltby,Stuart G Turville,Peter A B Wark,Nathan W Bartlett
Respiratory virus infections initiate and transmit from the upper respiratory tract (URT). Coronaviruses, including OC43, are a major cause of respiratory infection and disease. Failure to mount an effective antiviral immune response in the nasal mucosa increases the risk of severe disease and person-to-person transmission, highlighting the need for URT infection models to support the development of
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Reanalysis of Single-Cell RNA-Sequencing Data in Patients with COVID-19: Insights and Limitations. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Chi F Hung,Sina A Gharib
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Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Michael B Fessler,Jennifer H Madenspacher,Paul J Baker,Kerry L Hilligan,Andrea C Bohrer,Ehydel Castro,Julie Meacham,Shih-Heng Chen,Reed F Johnson,Jeffrey G McDonald,Negin P Martin,Charles J Tucker,Debabrata Mahapatra,Mark Cesta,Katrin D Mayer-Barber
Oxysterols (i.e., oxidized cholesterol species) have complex roles in biology. 25-Hydroxycholesterol (25HC), a product of the activity of cholesterol-25-hydroxylase (CH25H) on cholesterol, has recently been shown to be broadly antiviral, suggesting therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, 25HC can also amplify inflammation and be converted
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Eosinophil Phenotypes Are Functionally Regulated by Resolvin D2 during Allergic Lung Inflammation. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Thayse R Brüggemann,Hong Yong Peh,Luciana P Tavares,Julie Nijmeh,Ashley E Shay,Rafael M Rezende,Toby B Lanser,Charles N Serhan,Bruce D Levy
Eosinophils (Eos) reside in multiple organs during homeostasis and respond rapidly to an inflammatory challenge. Although Eos share chemical staining properties, they also demonstrate phenotypic and functional plasticity that is not fully understood. Here, we used a murine model of allergic lung inflammation to characterize Eos subsets and determine their spatiotemporal and functional regulation during
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Oxidized Phosphatidylcholines Trigger TRPA1 and Ryanodine Receptor-dependent Airway Smooth Muscle Contraction. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Jignesh Vaghasiya,Azadeh Dalvand,Anurag Sikarwar,Divleen Mangat,Mirna Ragheb,Katarina Kowatsch,Dheerendra Pandey,Seyed Mojtaba Hosseini,Tillie L Hackett,Soheila Karimi-Abdolrezaee,Amir Ravandi,Christopher D Pascoe,Andrew J Halayko
Asthma pathobiology includes oxidative stress that modifies cell membranes and extracellular phospholipids. Oxidized phosphatidylcholines (OxPCs) in lung lavage from allergen-challenged human participants correlate with airway hyperresponsiveness and induce bronchial narrowing in murine thin-cut lung slices. OxPCs activate many signaling pathways, but mechanisms for these responses are unclear. We
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Variations in S100A8/A12 Gene Expression Are Associated with the Efficacy of Nintedanib and Acute Exacerbation Development in Idiopathic Pulmonary Fibrosis Patients. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-08-01 Naoki Arai,Masayuki Nakajima,Masashi Matsuyama,Sosuke Matsumura,Kai Yazaki,Chio Sakai,Mizu Nonaka,Hidetoshi Yanai,Takeshi Numata,Yusuke Yamamoto,Yoshibumi Akatsu,Hiroaki Iijima,Yuko Morishima,Yosuke Matsuno,Takeo Endo,Masafumi Muratani,Yukio Ishii,Takefumi Saito,Nobuyuki Hizawa
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Diastolic Cardiomyopathy Secondary to Experimentally Induced Exacerbated Emphysema. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-08-01 Pierre-Edouard Grillet,Elodie Desplanche,Quentin Wynands,Fares Gouzi,Patrice Bideaux,Aurelie Fort,Valérie Scheuermann,Alain Lacampagne,Anne Virsolvy,Jérôme Thireau,Pieter de Tombe,Arnaud Bourdin,Olivier Cazorla
Chronic obstructive pulmonary disease (COPD) is a clinical entity of increasing significance. COPD involves abnormalities of the airways and, in emphysema, parenchymal pulmonary destruction. Cardiovascular disease has emerged as a significant comorbidity to COPD. Heart failure with preserved ejection fraction (HFpEF) appears to be particularly associated with COPD-emphysema. Traditional treatments
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Nrf2 Is Involved in Hyperglycemia-induced Abnormal Lung Development through both Antioxidation-Dependent and Antioxidation-Independent Activation. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-08-01 Mei-Yao He,Ping Zhang,Nannan Shi,Tingting Li,Jingyun Wang,Longkai He,Zefeng Liang,Linliang Song,Guang Wang,Xuesong Yang
Accumulating evidence has shown that hyperglycemia during pregnancy negatively affects lung development. However, the pathological mechanism of lung dysplasia caused by hyperglycemia remains unclear. In this study, we demonstrated the phenotypes of the impaired lung epithelial cell differentiation of mouse lungs in pregestational diabetes mellitus (PGDM) and gestational diabetes mellitus (GDM), and
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Meta-Analysis of COVID-19 BAL Single-Cell RNA Sequencing Reveals Alveolar Epithelial Transitions and Unique Alveolar Epithelial Cell Fates. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-12-01 Peer W F Karmaus,Aleksandra Tata,Julie M Meacham,Frank Day,David Thrower,Purushothama Rao Tata,Michael B Fessler
Single-cell RNA sequencing (scRNA-seq) of BAL cells has provided insights into coronavirus disease (COVID-19). However, reports have been limited by small patient cohorts. We performed a meta-analysis of BAL scRNA-seq data from healthy control subjects (n = 13) and patients with COVID-19 (n = 20), sourced from six independent studies (167,280 high-quality cells in total). Consistent with the source
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Aging Delays Lung Repair: Insights from Omics Analysis in Mice with Pulmonary Fibrosis. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-01 Jiurong Liang,Giovanni Ligresti
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Transcriptomic and Proteomic Changes Driving Pulmonary Fibrosis Resolution in Young and Old Mice. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-01 Jelena Weckerle,Christoph H Mayr,Katrin Fundel-Clemens,Bärbel Lämmle,Lukasz Boryn,Matthew J Thomas,Tom Bretschneider,Andreas H Luippold,Heinrich J Huber,Coralie Viollet,Wolfgang Rist,Daniel Veyel,Fidel Ramirez,Stephan Klee,Marc Kästle
Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis. Yet in this model, it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of aging. Old mice showed incomplete and delayed lung function recovery 8 weeks after bleomycin instillation
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Searching for an Animal Model with Clinical Features of Scleroderma. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-01 Harissios Vliagoftis,Satish K Madala
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Single-Cell RNA Sequencing Provides New Insights into Therapeutic Roles of Thyroid Hormone in Idiopathic Pulmonary Fibrosis. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-01 Lan Wang,Zhongzheng Li,Ruyan Wan,Xin Pan,Bin Li,Huabin Zhao,Juntang Yang,Weiming Zhao,Shenghui Wang,Qiwen Wang,Peishuo Yan,Chi Ma,Hongmei Yuan,Mengxia Zhao,Ivan Rosas,Chen Ding,Baofa Sun,Guoying Yu
Idiopathic pulmonary fibrosis (IPF) is a progressive fatal interstitial lung disease without an effective cure. Herein, we explore the role of 3,5,3'-triiodothyronine (T3) administration on lung alveolar regeneration and fibrosis at the single-cell level. T3 supplementation significantly altered the gene expression in fibrotic lung tissues. Immune cells were rapidly recruited into the lung after the
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Detection of Cells in Exhaled Breath Condensate Holds Potential for Pathophysiological Insights in Pulmonary Diseases. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-07-01 Letizia Palomba,Debora Paris,Annabella Tramice,Pasquale Ambrosino,Mauro Maniscalco,Andrea Motta
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Surfactant Protein Production during Maturation Is Enhanced by Natural Variability in Breathing. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-07-01 J Jane Pillow,Erzsébet Bartolák-Suki,Peter B Noble,Clare A Berry,Béla Suki
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Peripheral Blood Omics and Other Multiplex-based Systems in Pulmonary and Critical Care Medicine. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-01 Joseph Balnis,Eitel J M Lauria,Recai Yucel,Harold A Singer,Reid S Alisch,Ariel Jaitovich
Over the last years, the use of peripheral blood-derived big datasets in combination with machine learning technology has accelerated the understanding, prediction, and management of pulmonary and critical care conditions. The goal of this article is to provide readers with an introduction to the methods and applications of blood omics and other multiplex-based technologies in the pulmonary and critical
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Molecular Features and Stages of Pulmonary Fibrosis Driven by Type 2 Inflammation. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-01 Hamid Mattoo,Dinesh S Bangari,Sheila Cummings,Zachary Humulock,David Habiel,Ethan Y Xu,Nathan Pate,Robert Resnick,Virginia Savova,George Qian,Christian Beil,Ercole Rao,Frank O Nestle,Paul J Bryce,Arun Subramaniam
Systemic sclerosis (SSc) is a progressive, multiorgan disease with limited treatment options. Although a recent proof-of-concept study using romilkimab or SAR156597, a bispecific IL-4/IL-13 antibody, suggests a direct role of these cytokines in the pathophysiology of SSc, their contributions to the balance between inflammation and fibrosis are unclear. Here, we determine the roles of type 2 inflammation
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Against the Waves: Blocking the EB3-IP3 Interaction Inhibits Calcium Waves in the Lung Endothelium. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-10-01 Shervin S Takyar
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Come, Sweet Death: Why Endothelial Cells Die in Fructose. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-09-01 Wolfgang M Kuebler
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SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-11-01 Min Li,Lydie Plecitá-Hlavatá,Evgenia Dobrinskikh,B Alexandre McKeon,Aneta Gandjeva,Suzette Riddle,Aya Laux,Ram Raj Prasad,Sushil Kumar,Rubin M Tuder,Hui Zhang,Cheng-Jun Hu,Kurt R Stenmark
Pulmonary hypertension (PH) is a heterogeneous and life-threatening cardiopulmonary disorder in which mitochondrial dysfunction is believed to drive pathogenesis, although the underlying mechanisms remain unclear. To determine if abnormal SIRT3 (sirtuin 3) activity is related to mitochondrial dysfunction in adventitial fibroblasts from patients with idiopathic pulmonary arterial hypertension (IPAH)
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Efficient Adeno-associated Virus-mediated Transgenesis in Alveolar Stem Cells and Associated Niches. Am. J. Respir. Cell Mol. Biol. (IF 6.4) Pub Date : 2023-09-01 Arvind Konkimalla,Zachary Elmore,Satoshi Konishi,Lauren Macadlo,Hiroaki Katsura,Aleksandra Tata,Aravind Asokan,Purushothama Rao Tata
Targeted delivery of transgenes to tissue-resident stem cells and related niches offers avenues for interrogating pathways and editing endogenous alleles for therapeutic interventions. Here, we survey multiple adeno-associated virus (AAV) serotypes, administered via intranasal and retroorbital routes in mice, to target lung alveolar stem cell niches. We found that AAV5, AAV4, and AAV8 efficiently and