-
SOX6 AU controls myogenesis by cis-modulation of SOX6 in cattle Epigenetics (IF 3.7) Pub Date : 2024-04-14 Xin Li, Shan-Shan Xing, Sheng-Bo Meng, Zhong-Yi Hou, Lei Yu, Meng-Juan Chen, Dong-Dong Yuan, Hui-Fen Xu, Han-Fang Cai, Ming Li
Long non-coding RNAs (lncRNAs) have been shown to be involved in the regulation of skeletal muscle development through multiple mechanisms. The present study revealed that the lncRNA SOX6 AU (SRY-b...
-
Study on chromatin regulation patterns of expression vectors in the PhiC31 integration site Epigenetics (IF 3.7) Pub Date : 2024-04-09 Xueli Liu, Qina Chen, Xudong Yin, Xiao Wang, Jinshan Ran, Wei Yu, Bin Wang
The PhiC31 integration system allows for targeted and efficient transgene integration and expression by recognizing pseudo attP sites in mammalian cells and integrating the exogenous genes into the...
-
Vitamin C enhances co-localization of novel TET1 nuclear bodies with both Cajal and PML bodies in colorectal cancer cells Epigenetics (IF 3.7) Pub Date : 2024-04-07 Nour El Osmani, Corinne Prévostel, Laurence Picque Lasorsa, Mohammad El Harakeh, Zeina Radwan, Hiba Mawlawi, Marwan El Sabban, Margret Shirinian, Zeina Dassouki
Deregulation of ten-eleven Translocation protein 1 (TET1) is commonly reported to induce imbalances in gene expression and subsequently to colorectal cancer development (CRC). On the other hand, vi...
-
Trauma context exerts intergenerational effects on child mental health via DNA methylation Epigenetics (IF 3.7) Pub Date : 2024-04-05 Stefanie Pilkay, Andie Riffer, Andrew Carroll
Many people experience traumatic or negative events, but few develop mental health issues as a result. This study investigated whether newborn DNA methylation (DNAm) previously associated with mate...
-
Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations Epigenetics (IF 3.7) Pub Date : 2024-04-03 Jessica I. Lundin, Ulrike Peters, Yao Hu, Farah Ammous, Christy L. Avery, Emelia J. Benjamin, Joshua C. Bis, Jennifer A. Brody, Chris Carlson, Mary Cushman, Chris Gignoux, Xiuqing Guo, Jeff Haessler, Chris Haiman, Roby Joehanes, Silva Kasela, Eimear Kenny, Tuuli Lapalainien, Daniel Levy, Chunyu Liu, Yongmei Liu, Ruth J.F. Loos, Ake Lu, Tara Matise, Kari E. North, Sungshim L. Park, Scott M. Ratliff
Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflam...
-
Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays Epigenetics (IF 3.7) Pub Date : 2024-04-02 Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, David Lukacsovich, Achintya Varma, X. Steven Chen, Brian Kunkle, Eden R. Martin, Lily Wang
DNA methylation (DNAm) plays a crucial role in a number of complex diseases. However, the reliability of DNAm levels measured using Illumina arrays varies across different probes. Previous research...
-
Upregulation of GPR133 expression impaired the phagocytosis of macrophages in recurrent spontaneous miscarriage Epigenetics (IF 3.7) Pub Date : 2024-04-02 Jia-Xue Sun, Yongli Yao, Wen-Xuan Li, Xin Su, Haoyu Yang, Zhouping Lu, Chenfei Liu, Xiang-Hong Xu, Liping Jin
Decidual macrophages are the second-largest immune cell group at the maternal-foetal interface. They participate in apoptotic cell removal, and protect the foetus from microorganisms or pathogens. ...
-
DNA methylation markers for risk of metastasis in a cohort of men with localized prostate cancer Epigenetics (IF 3.7) Pub Date : 2024-03-25 Talar S. Habeshian, Kimberly L. Cannavale, Jeff M. Slezak, Yu-Hsiang Shu, Gary W. Chien, XuFeng Chen, Feng Shi, Kimberly D. Siegmund, Stephen K. Van Den Eeden, Jiaoti Huang, Chun R. Chao
Accurately identifying life-threatening prostate cancer (PCa) at time of diagnosis remains an unsolved problem. We evaluated whether DNA methylation status of selected candidate genes can predict t...
-
Non-coding 886 (nc886/vtRNA2-1), the epigenetic odd duck – implications for future studies Epigenetics (IF 3.7) Pub Date : 2024-03-25 Emma Raitoharju, Sonja Rajić, Saara Marttila
Non-coding 886 (nc886, vtRNA2–1) is the only human polymorphically imprinted gene, in which the methylation status is not determined by genetics. Existing literature regarding the establishment, st...
-
Calling the question: what is mammalian transgenerational epigenetic inheritance? Epigenetics (IF 3.7) Pub Date : 2024-03-25 Hasan Khatib, Jessica Townsend, Melissa A. Konkel, Gabi Conidi, Julia A. Hasselkus
While transgenerational epigenetic inheritance has been extensively documented in plants, nematodes, and fruit flies, its existence in mammals remains controversial. Several factors have contribute...
-
Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene Epigenetics (IF 3.7) Pub Date : 2024-03-25 Caiqing Zheng, Ling Ma, Fan Song, Li Tian, Wanzhi Cai, Hu Li, Yuange Duan
Although A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by ‘epigenetically’ regulating proteomic div...
-
Epigenetic landscape of 5-hydroxymethylcytosine and associations with gene expression in placenta Epigenetics (IF 3.7) Pub Date : 2024-03-20 Michael Mortillo, Elizabeth G. Kennedy, Karen M. Hermetz, Amber A. Burt, Carmen J. Marsit
5-hydroxymethylcystosine (5hmC), is an intermediate product in the DNA demethylation pathway, but may act as a functional epigenetic modification. We have conducted the largest study of site-specif...
-
The one-carbon metabolism as an underlying pathway for placental DNA methylation – a systematic review Epigenetics (IF 3.7) Pub Date : 2024-03-14 Marjolein M van Vliet, Sam Schoenmakers, Joost Gribnau, Régine P.M. Steegers-Theunissen
Epigenetic modifications, including DNA methylation, are proposed mechanisms explaining the impact of parental exposures to foetal development and lifelong health. Micronutrients including folate, ...
-
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage Epigenetics (IF 3.7) Pub Date : 2024-03-11 Fengfeng Li, Fang Wang, Lei Wang, Jianhua Wang, Shanshan Wei, Junjun Meng, Yanan Li, Lei Feng, Pei Jiang
Oxidative stress and neuronal dysfunction caused by intracerebral haemorrhage (ICH) can lead to secondary injury. The m6A modification has been implicated in the progression of ICH. This study aime...
-
DNA methylation heterogeneity attributable to a complex tumor immune microenvironment prompts prognostic risk in glioma Epigenetics (IF 3.7) Pub Date : 2024-03-05 Shuangyue Ma, Xu Pan, Jing Gan, Xiaxin Guo, Jiaheng He, Haoyu Hu, Yuncong Wang, Shangwei Ning, Hui Zhi
Gliomas are malignant tumours of the human nervous system with different World Health Organization (WHO) classifications, glioblastoma (GBM) with higher grade and are more malignant than lower-grad...
-
Novel DNA methylation changes in mouse lungs associated with chronic smoking Epigenetics (IF 3.7) Pub Date : 2024-03-04 Chinonye Doris Onuzulu, Samantha Lee, Sujata Basu, Jeannette Comte, Yan Hai, Nikho Hizon, Shivam Chadha, Maria Shenna Fauni, Andrew J. Halayko, Christopher D. Pascoe, Meaghan J. Jones
Smoking is a potent cause of asthma exacerbations, chronic obstructive pulmonary disease (COPD) and many other health defects, and changes in DNA methylation (DNAm) have been identified as a potent...
-
TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy Epigenetics (IF 3.7) Pub Date : 2024-03-03 Ji Ren, Xiuying Chen, Jing Li, Yuxin Zan, Shan Wang, Yujie Tan, Yan Ding
Methylation modifications play pertinent roles in regulating gene expression and various biological processes. The silencing of the demethylase enzyme TET1 can affect the expressions of key oncogen...
-
Epigenome-wide association study of long-term psychosocial stress in older adults Epigenetics (IF 3.7) Pub Date : 2024-03-03 Lauren A. Opsasnick, Wei Zhao, Lauren L. Schmitz, Scott M. Ratliff, Jessica D. Faul, Xiang Zhou, Belinda L. Needham, Jennifer A. Smith
Long-term psychosocial stress is strongly associated with negative physical and mental health outcomes, as well as adverse health behaviours; however, little is known about the role that stress pla...
-
One-carbon metabolism nutrients impact the interplay between DNA methylation and gene expression in liver, enhancing protein synthesis in Atlantic salmon Epigenetics (IF 3.7) Pub Date : 2024-02-25 Takaya Saito, Marit Espe, Vibeke Vikeså, Christoph Bock, Tårn H. Thomsen, Anne‐Catrin Adam, Jorge M.O. Fernandes, Kaja H. Skjaerven
Supplementation of one-carbon (1C) metabolism micronutrients, which include B-vitamins and methionine, is essential for the healthy growth and development of Atlantic salmon (Salmo salar). However,...
-
Association of changes in expression of HDAC and SIRT genes after drug treatment with cancer cell line sensitivity to kinase inhibitors Epigenetics (IF 3.7) Pub Date : 2024-02-18 Julia Krushkal, Yingdong Zhao, Kyle Roney, Weimin Zhu, Alan Brooks, Deborah Wilsker, Ralph E. Parchment, Lisa M. McShane, James H. Doroshow
Histone deacetylases (HDACs) and sirtuins (SIRTs) are important epigenetic regulators of cancer pathways. There is a limited understanding of how transcriptional regulation of their genes is affect...
-
Genetic confounds of transgenerational epigenetic inheritance in mice Epigenetics (IF 3.7) Pub Date : 2024-02-18 Daniel M. Sapozhnikov, Moshe Szyf
Transgenerational epigenetic inheritance in mammals remains a controversial phenomenon. A recent study by Takahashi et al. provides evidence for this mode of inheritance in mice by using a CRISPR/C...
-
Using methylation data to improve transcription factor binding prediction Epigenetics (IF 3.7) Pub Date : 2024-02-01 Daniel Morgan, Dawn L. DeMeo, Kimberly Glass
Modelling the regulatory mechanisms that determine cell fate, response to external perturbation, and disease state depends on measuring many factors, a task made more difficult by the plasticity of...
-
Epigenetic changes in pyloric caeca of Atlantic salmon fed diets containing increasing levels of lipids and choline Epigenetics (IF 3.7) Pub Date : 2024-01-28 Anusha K.S. Dhanasiri, Daphne Siciliani, Trond M. Kortner, Åshild Krogdahl
An earlier study of ours investigating the effect of dietary lipid levels on the choline requirement of Atlantic salmon showed increasing severity of intestinal steatosis with increasing lipid leve...
-
Hypomethylation at H19DMR in penile squamous cell carcinoma is not related to HPV infection Epigenetics (IF 3.7) Pub Date : 2024-01-21 Renan da Silva Santos, Daniel Pascoalino Pinheiro, Carlos Gustavo Hirth, Maria Júlia Barbosa Bezerra, Isabelle Joyce de Lima Silva-Fernandes, Francisca Andréa da Silva Oliveira, Maisa Viana de Holanda Barros, Ester Silveira Ramos, Arlindo A. Moura, Odorico de Moraes Manoel Filho, Claudia Pessoa, Cristiana Libardi Miranda Furtado
Penile squamous cell carcinoma (SCC) is a rare and aggressive tumour mainly related to lifestyle behaviour and human papillomavirus (HPV) infection. Environmentally induced loss of imprinting (LOI)...
-
DNA methylation variation and growth in the clonal Duchesnea indica is regulated by both past and present lead environments Epigenetics (IF 3.7) Pub Date : 2024-01-21 Jiaxin Quan, Shanshan Song, Linya Xing, Xiao Liu, Ming Yue
Studies suggest that clonal plants’ ability to select habitats and forage in a heterogeneous environment is influenced by their past environment, with stress legacy potentially playing a crucial ro...
-
Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome Epigenetics (IF 3.7) Pub Date : 2024-01-21 Cristiana Libardi Miranda Furtado, Megan Hansen, Gislaine Satyko Kogure, Victor Barbosa Ribeiro, Nathanael Taylor, Murilo Racy Soares, Rui Alberto Ferriani, Kenneth Ivan Aston, Timothy Jenkins, Rosana Maria dos Reis
Physical activity is a first-line treatment for polycystic ovary syndrome (PCOS). Resistance or aerobic exercise improves metabolic complications, reproductive outcomes, and quality of life in PCOS...
-
LncRNA NEAT1 aggravates human microvascular endothelial cell injury by inhibiting the Apelin/Nrf2/HO-1 signalling pathway in type 2 diabetes mellitus with obstructive sleep apnoea Epigenetics (IF 3.7) Pub Date : 2024-01-17 Kai Chen, Baiqing Ou, Quan Huang, Daqing Deng, Yi Xiang, Fang Hu
Long noncoding RNAs (lncRNAs) regulate the progression of type 2 diabetes mellitus complicated with obstructive sleep apnoea (T2DM-OSA). However, the role of the lncRNA nuclear paraspeckle assembly...
-
Animal and plant protein intake during infancy and childhood DNA methylation: a meta-analysis in the NutriPROGRAM consortium Epigenetics (IF 3.7) Pub Date : 2024-01-10 Mohammed El Sharkawy, Janine F. Felix, Veit Grote, Trudy Voortman, Vincent W. V. Jaddoe, Berthold Koletzko, Leanne K. Küpers
Higher early-life animal protein intake is associated with a higher childhood obesity risk compared to plant protein intake. Differential DNA methylation may represent an underlying mechanism.We an...
-
ZSCAN25 methylation predicts seizures and severe alcohol withdrawal syndrome Epigenetics (IF 3.7) Pub Date : 2024-01-03 Allan Andersen, Emily Milefchik, Emma Papworth, Brandan Penaluna, Kelsey Dawes, Joanna Moody, Gracie Weeks, Ellyse Froehlich, Kaitlyn deBlois, Jeffrey D Long, Robert Philibert
Currently, clinicians use their judgement and indices such as the Prediction of Alcohol Withdrawal Syndrome Scale (PAWSS) to determine whether patients are admitted to hospitals for consideration o...
-
Plasma methylated GNB4 and Riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma Epigenetics (IF 3.7) Pub Date : 2023-12-28 Yanteng Zhao, Lei Zhao, Huifang Jin, Ying Xie, Liyinghui Chen, Wei Zhang, Lanlan Dong, Lianglu Zhang, Yue Huang, Kangkang Wan, Qiankun Yang, Shaochi Wang
Early detection of hepatocellular carcinoma (HCC) can greatly improve the survival rate of patients. We aimed to develop a novel marker panel based on cell-free DNA (cfDNA) methylation for the dete...
-
History of exposure to copper influences transgenerational gene expression responses in Daphnia magna Epigenetics (IF 3.7) Pub Date : 2023-12-28 Guilherme Jeremias, Ana-Belén Muñiz-González, Fernando José Mendes Gonçalves, José-Luis Martínez-Guitarte, Jana Asselman, Joana Luísa Pereira
The establishment of transgenerational effects following chemical exposure is a powerful phenomenon, capable of modulating ecosystem health beyond exposure periods. This study assessed the transgen...
-
N6-methyladenosine methylation analysis of long noncoding RNAs and mRNAs in 5-FU-resistant colon cancer cells Epigenetics (IF 3.7) Pub Date : 2023-12-25 Jie Lai, Zhiyong Zhou, Kan Hu, HongLong Yu, Xingyao Su, Xiaoqiang Niu, Huizi Li, Shengxun Mao
N6 methyladenosine (m6A), methylation at the sixth N atom of adenosine, is the most common and abundant modification in mammalian mRNAs and non-coding RNAs. Increasing evidence shows that the alter...
-
Imprinted gene alterations in the kidneys of growth restricted offspring may be mediated by a long non-coding RNA Epigenetics (IF 3.7) Pub Date : 2023-12-21 Thu N. A. Doan, James M. Cowley, Aaron L. Phillips, Jessica F. Briffa, Shalem Y. Leemaqz, Rachel A. Burton, Tania Romano, Mary E. Wlodek, Tina Bianco-Miotto
Altered epigenetic mechanisms have been previously reported in growth restricted offspring whose mothers experienced environmental insults during pregnancy in both human and rodent studies. We prev...
-
Chronic intermittent ethanol exposure-induced m6A modifications around mRNA stop codons of opioid receptor genes Epigenetics (IF 3.7) Pub Date : 2023-12-20 Ying Liu, Ji Sun Koo, Huiping Zhang
Chronic alcohol consumption may alter mRNA methylation and expression levels of genes related to addiction and reward in the brain, potentially contributing to alcohol tolerance and dependence. Neu...
-
Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth Epigenetics (IF 3.7) Pub Date : 2023-12-15 Adriana C. Vidal, David W. Sosnowski, Joddy Marchesoni, Carole Grenier, John Thorp, Susan K. Murphy, Sara B. Johnson, Billy Schlief, Cathrine Hoyo
Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of matern...
-
Impact of folic acid supplementation on the epigenetic profile in healthy unfortified individuals – a randomized intervention trial Epigenetics (IF 3.7) Pub Date : 2023-12-14 Karin B. Michels, Alexandra M. Binder
Folate is an essential mediator in one-carbon metabolism, which provides methyl groups for DNA synthesis and methylation. The availability of active methyl groups can be influenced by the uptake of...
-
Cut&tag: a powerful epigenetic tool for chromatin profiling Epigenetics (IF 3.7) Pub Date : 2023-12-17 Zhijun Fu, Sanjie Jiang, Yiwen Sun, Shanqiao Zheng, Liang Zong, Peipei Li
Analysis of transcription factors and chromatin modifications at the genome-wide level provides insights into gene regulatory processes, such as transcription, cell differentiation and cellular res...
-
Detailed immune profiling in pediatric Crohn’s disease using methylation cytometry Epigenetics (IF 3.7) Pub Date : 2023-12-13 Samuel R. Reynolds, Lucas A. Salas, Ji-Qing Chen, Brock C. Christensen
DNA methylation has been extensively utilized to study epigenetic patterns across many diseases as well as to deconvolve blood cell type proportions. This study builds upon previous studies examini...
-
WGBS of embryonic gonads revealed that long non-coding RNAs in the MHM region might be involved in cell autonomous sex identity and female gonadal development in chickens Epigenetics (IF 3.7) Pub Date : 2023-12-01 Ligen Chen, Yu Cheng, Guixin Zhang, Yang Zhou, Zhen Zhang, Qianhong Chen, Yanping Feng
DNA methylation plays a key role in sex determination and differentiation in vertebrates. However, there are few studies on DNA methylation involved in chicken gonad development, and most focused o...
-
DNA hydroxymethylation differences underlie phenotypic divergence of somatic growth in Nile tilapia reared in common garden Epigenetics (IF 3.7) Pub Date : 2023-11-27 Ioannis Konstantinidis, Pål Sætrom, S.O. Brieuc, Kjetill S. Jakobsen, Hannes Liedtke, Caroline Pohlmann, Thomais Tsoulia, Jorge M. O. Fernandes
Phenotypic plasticity of metabolism and growth are essential for adaptation to new environmental conditions, such as those experienced during domestication. Epigenetic regulation plays a key role i...
-
Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm Epigenetics (IF 3.7) Pub Date : 2023-11-20 Uriel Paniagua, Barry M. Lester, Carmen J. Marsit, Marie Camerota, Brian S. Carter, Jennifer F. Check, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Sheri A. DellaGrotta, Lynne M. Dansereau, T. Michael O’Shea, Todd M. Everson
Epigenetic age acceleration is a risk factor for chronic diseases of ageing and may reflect aspects of biological ageing. However, few studies have examined epigenetic ageing during the early neona...
-
DNA methylation profiles in bovine sperm are associated with daughter fertility Epigenetics (IF 3.7) Pub Date : 2023-11-20 Ying Zhang, Clément Plessis, Julien Prunier, Hélène Martin, Rémi Labrecque, Marc André Sirard
The current decline in dairy cattle fertility has resulted in significant financial losses for dairy farmers. In the past, most efforts to improve dairy cattle fertility have been focused on either...
-
Gaps in current methods to detect polymorphic CpGs from Illumina Infinium human methylation microarrays and exploring their potential impact in multi-EWAS analyses Epigenetics (IF 3.7) Pub Date : 2023-11-20 Basharat Bhat, Gregory T Jones
DNA methylation (DNAm) epigenome-wide association studies (EWAS) have been performed on diverse ethnicities to discover novel biomarkers associated with various diseases, such as cancers, autoimmun...
-
Examination of newborn DNA methylation among women with polycystic ovary syndrome/hirsutism Epigenetics (IF 3.7) Pub Date : 2023-11-22 Kristen J. Polinski, Sonia L. Robinson, Diane L. Putnick, Rajeshwari Sundaram, Erin Bell, Paule V. Joseph, James Segars, Weihua Guan, Robert M. Silver, Enrique F. Schisterman, Sunni L. Mumford, Edwina H. Yeung
Research suggests that polycystic ovary syndrome (PCOS) traits (e.g., hyperandrogenism) may create a suboptimal intrauterine environment and induce epigenetic modifications. Therefore, we assessed ...
-
Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury Epigenetics (IF 3.7) Pub Date : 2023-11-18 Tongtong Ma, Junjie Wu, Zhongqing Chen
Sepsis is the primary cause of acute kidney injury (AKI) and is associated with high mortality rates. Growing evidence suggests that noncoding RNAs are vitally involved in kidney illnesses, whereas...
-
Analysis of the interplay between MeCP2 and histone H1 during in vitro differentiation of human ReNCell neural progenitor cells Epigenetics (IF 3.7) Pub Date : 2023-11-17 Edilene Siqueira, Bo-Hyun Kim, Larry Reser, Robert Chow, Kerry Delaney, Manel Esteller, Mark M. Ross, Jeffrey Shabanowitz, Donald F. Hunt, Sonia Guil, Juan Ausiö
An immortalized neural cell line derived from the human ventral mesencephalon, called ReNCell, and its MeCP2 knock out were used. With it, we characterized the chromatin compositional transitions u...
-
Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma Epigenetics (IF 3.7) Pub Date : 2023-11-05 Zhenyi Lv, Wenqi Gao, Zhiwei Du, Yi Zheng, Tianming Liu, Chenjun Hao, Dongbo Xue
Alternative splicing is a process causing mRNA translation to produce different proteins, and it is crucial for the development of tumours. In this study, we constructed a prognostic model related ...
-
A newly identified lncRNA lnc000100 regulates proliferation and differentiation of cattle skeletal muscle cells Epigenetics (IF 3.7) Pub Date : 2023-11-01 Mengke Ma, Mengjie Chen, Xiaoyun Wu, Suren R. Sooranna, Qingyou Liu, Deshun Shi, Jian Wang, Hui Li
Cattle skeletal muscle development is a complex and highly coordinated biological process mediated by a series of myogenic regulators, which plays a critical role in beef yield and quality. Long no...
-
ELOVL2-AS1 suppresses tamoxifen resistance by sponging miR-1233-3p in breast cancer Epigenetics (IF 3.7) Pub Date : 2023-10-31 Hyeon Woo Kim, Minjae Baek, Sanghyun Jung, Siyeon Jang, Hyeonjin Lee, Seung-Hoon Yang, Beom Seok Kwak, Sun Jung Kim
Tamoxifen (Tam) has long been a top treatment option for breast cancer patients, but the challenge of eliminating cancer recurrence remains. Here, we identify a signalling pathway involving ELOVL2,...
-
Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research Epigenetics (IF 3.7) Pub Date : 2023-10-29 Lu Gao, Zhou Zhang, Xiao-Long Cui, Diana West-Szymanski, Chang Ye, Chuan He, Wei Zhang, Marc Bissonnette
Background: Elucidating epigenetic mechanisms could provide new biomarkers for disease diagnosis and prognosis. Technological advances allow genome-wide profiling of 5-hydroxymethylcytosines (5hmC)...
-
Epigenome-wide association study of systemic effects of obesity susceptibility in human twins Epigenetics (IF 3.7) Pub Date : 2023-10-23 Glen E. Duncan, Ally Avery, Millissia Ben Maamar, Eric E. Nilsson, Daniel Beck, Michael K. Skinner
The current study was designed to use an epigenome-wide association approach (EWAS) to identify potential systemic DNA methylation alterations that are associated with obesity using 22 discordant t...
-
IL-18 serves as a main effector of CAF-derived METTL3 against immunosuppression of NSCLC via driving NF-κB pathway Epigenetics (IF 3.7) Pub Date : 2023-10-23 Li Xu, Kang Li, Jia Li, Fang Xu, Shuzhi Liang, Yi Kong, Bolin Chen
Background: N6-methyladenosine (m6A) is the most abundant modification in eukaryotic mRNA. However, its role in non-small cell lung cancer (NSCLC) has not been completely elucidated.Objective: To e...
-
Domain architecture and protein–protein interactions regulate KDM5A recruitment to the chromatin Epigenetics (IF 3.7) Pub Date : 2023-10-15 Avishek Kataria, Shweta Tyagi
Tri-methylation of Histone 3 lysine 4 (H3K4) is an important epigenetic modification whose deposition and removal can affect the chromatin at structural and functional levels. KDM5A is one of the f...
-
Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL Epigenetics (IF 3.7) Pub Date : 2023-10-15 Atsushi Watanabe, Kunio Miyake, Yuriko Yamada, Ei-Ichiro Sunamura, Takuya Yotani, Keiko Kagami, Shin Kasai, Minori Tamai, Daisuke Harama, Koshi Akahane, Kumiko Goi, Kimiyoshi Sakaguchi, Hiroaki Goto, Shinichiro Kitahara, Takeshi Inukai
Asparaginase is an important agent for the treatment of acute lymphoblastic leukaemia (ALL), but it is occasionally associated with severe adverse events. Thus, for safer and more efficacious thera...
-
ATG9A modulated by miR-195-5p can boost the malignant progression of cervical cancer cells Epigenetics (IF 3.7) Pub Date : 2023-10-02 Xiaomin Liu, Zhen Liu, Yonggang Liu, Ning Wang
Cervical cancer (CC) is a major public health problem, and its molecular mechanism requires further investigation. The goal of this study was to determine the role of miR-195-5p and the autophagy-r...
-
N6-methyladenosine (m6A) modification in osteosarcoma: expression, function and interaction with noncoding RNAs – an updated review Epigenetics (IF 3.7) Pub Date : 2023-09-28 Yuanzhuang Zhang, Yeqiu Xu, Yuxin Bao, Yinzhou Luo, Guanzhen Qiu, Ming He, Jie Lu, Jian Xu, Bin Chen, Yong Wang
Osteosarcoma, originating from primitive bone-forming mesenchymal cells, is the most common malignant bone tumour among children and adolescents. N6-methyladenosine (m6A), the most ubiquitous type ...
-
Sex-specific DNA methylation and transcription of zbtb38 and effects of gene–environment interactions on its natural antisense transcript in zebrafish Epigenetics (IF 3.7) Pub Date : 2023-10-02 Fabien Pierron, Flore Daramy, Débora Heroin, Guillemine Daffe, Aurélien Barré, Olivier Bouchez, Macha Nikolski
There is increasing evidence for the involvement of epigenetics in sex determination, maintenance, and plasticity, from plants to humans. In our previous work, we reported a transgenerational femin...
-
The influence of intergenerational trauma on epigenetics and obesity in Indigenous populations - a scoping review Epigenetics (IF 3.7) Pub Date : 2023-09-26 Krista Schafte, Sean Bruna
Background: Research has recently begun to examine the potential intergenerational impacts of trauma on obesity.Objective: This scoping review examines the literature on the interactions between in...
-
To target or not to target? The role of DNA and histone methylation in bacterial infections Epigenetics (IF 3.7) Pub Date : 2023-09-20 Magdalena Barbachowska, Paola B. Arimondo
Epigenetics describes chemical modifications of the genome that do not alter DNA sequence but participate in the regulation of gene expression and cellular processes such as proliferation, division...
-
A consistent pattern of slide effects in Illumina DNA methylation BeadChip array data Epigenetics (IF 3.7) Pub Date : 2023-09-20 Julian Hecker, Sanghun Lee, Priyadarshini Kachroo, Dmitry Prokopenko, Anna Maaser-Hecker, Sharon M. Lutz, Georg Hahn, Rafael Irizarry, Scott T. Weiss, Dawn L. DeMeo, Christoph Lange
Background: Recent studies have identified thousands of associations between DNA methylation CpGs and complex diseases/traits, emphasizing the critical role of epigenetics in understanding disease ...