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Corrigendum to “Ancient DNA traces a Chinese 5400-year-old cat specimen as leopard cat (Prionailurus bengalensis)” [Journal of Genetics and Genomics (2022) 49, 1076–1079] J. Genet. Genomics (IF 5.9) Pub Date : 2024-04-18 Shilun Zhu, Zehui Chen, Songmei Hu, Weilin Wang, Peng Cao, Feng Liu, Qingyan Dai, Xiaotian Feng, Ruowei Yang, Wanjing Ping, Qiaomei Fu
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The origin of two divergent ovine β-globin haplotypes and their potential association with environmental adaptation J. Genet. Genomics (IF 5.9) Pub Date : 2024-04-06 Yuxin Kang, Yilin Liang, Fengting Fan, Hojjat Asadollahpour Nanaei, Chunna Cao, Yu Jiang, Xianyong Lan, Chuanying Pan, Ran Li
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microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation J. Genet. Genomics (IF 5.9) Pub Date : 2024-04-04 Xinghan Chen, Yueru Shen, Zheng Song, Xinliang Wang, Huaitong Yao, Yuan Cai, Ziang Zhao, Bing Hu
MicroRNAs (miRNAs) play a significant role in axon regeneration following spinal cord injury. However, the functions of numerous miRNAs in axon regeneration within the central nervous system (CNS) remain largely unexplored. Here, we elucidate the positive role of miR-2184 in axon regeneration within zebrafish Mauthner cells (M-cells). The upregulation of miR-2184 in the single M-cells facilitates axon
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Whole-genome resequencing of Hu sheep identifies candidate genes associated with agronomic traits J. Genet. Genomics (IF 5.9) Pub Date : 2024-04-04 Liming Zhao, Lvfeng Yuan, Fadi Li, Xiaoxue Zhang, Huibin Tian, Zongwu Ma, Deyin Zhang, Yukun Zhang, Yuan Zhao, Kai Huang, Xiaolong Li, Jiangbo Cheng, Dan Xu, Xiaobin Yang, Kunchao Han, Xiuxiu Weng, Weimin Wang
The phenotypic diversity resulting from artificial or natural selection of sheep has made a significant contribution to human civilization. Hu sheep are a local sheep breed unique to China with high reproductive rates and rapid growth. Genome selection signatures have been widely used to investigate the genetic mechanisms underlying phenotypic variation in livestock. Here, we conduct whole-genome sequencing
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The OsCLV2s and OsCRN1 regulate grain shape in rice J. Genet. Genomics (IF 5.9) Pub Date : 2024-04-03 Xingxing Li, Meng-en Wu, Juncheng Zhang, Jingyue Xu, Yuanfei Diao, Yibo Li
The highly conserved CLV–WUS negative feedback pathway plays a decisive role in regulating stem cell maintenance in shoot and floral meristems in higher plants, including Arabidopsis, rice, maize, and tomato. Here, we report the discovery that -like genes directly regulate grain shape in rice. We find significant natural variations in the , , and loci in a genome-wide association study of grain shape
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Both gain- and loss-of-function variants of KCNA1 are associated with paroxysmal kinesignic dyskinesia J. Genet. Genomics (IF 5.9) Pub Date : 2024-04-02 Wan-Bing Sun, Jing-Xin Fu, Yu-Lan Chen, Hong-Fu Li, Zhi-Ying Wu, Dian-Fu Chen
is the coding gene for Kv1.1 voltage-gated potassium-channel α subunit. Three variants of have been reported to manifest as paroxysmal kinesignic dyskinesia (PKD), but the correlation between them remains unclear due to the phenotypic complexity of variants as well as the rarity of PKD cases. Using the whole exome sequencing followed by Sanger sequencing, we screen potential pathogenic variants in
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Chromosome-scale genomes of Quercus sichourensis and Quercus rex provide insights into the evolution and adaptation of Fagaceae J. Genet. Genomics (IF 5.9) Pub Date : 2024-04-02 Xue Liu, Weixiong Zhang, Yongting Zhang, Jing Yang, Peng Zeng, Zunzhe Tian, Weibang Sun, Jing Cai
The , a plant family with a wide distribution and diverse adaptability, has garnered significant interest as a subject of study in plant speciation and adaptation. Meanwhile, certain species are regarded as highly valuable wood resources due to the exceptional quality of their wood. In this study, we present two high-quality, chromosome-scale genome sequences for (848.75 Mb) and (883.46 Mb). Comparative
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The functional role of circular ribonucleic acid CHRC through miR-431-5p/KLF15 signaling axis in the progression of heart failure J. Genet. Genomics (IF 5.9) Pub Date : 2024-04-02 Yi Hu, Huaming Cao, Jie Sheng, Yizhuo Sun, Yuping Zhu, Qin Lin, Na Yi, Siyu He, Luying Peng, Li Li
Pathological myocardial hypertrophy is a common early clinical manifestation of heart failure, with noncoding RNAs exerting regulatory influence. However, the molecular function of circular ribonucleic acids (circRNAs) in the progression from cardiac hypertrophy to heart failure remains unclear. To uncover functional circRNAs and identify the core circRNA signaling pathway in heart failure, we construct
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Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100A8/9 expression J. Genet. Genomics (IF 5.9) Pub Date : 2024-04-02 Qiao Meng, Jing Ning, Jingjing Lu, Jing Zhang, Ming Zu, Jing Zhang, Xiurui Han, Huiling Zheng, Yueqing Gong, Xinyu Hao, Ying Xiong, Fang Gu, Wenling Han, Weiwei Fu, Jun Wang, Shigang Ding
The dysfunction of innate immunity components is one of the major drivers for ulcerative colitis (UC), and increasing reports indicate that gut microbiome serves as an intermediate between genetic mutations and UC development. Here, we find that the IL-17 receptor subunit, CMTM4, is reduced in UC patients and dextran sulfate sodium (DSS)-induced colitis. The deletion of CMTM4 () in mice leads to a
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A role for retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family J. Genet. Genomics (IF 5.9) Pub Date : 2024-04-01 Shuang Zhao, Chen Wang, Haiping Luo, Feifei Li, Qiang Wang, Jin Xu, Zhibin Huang, Wei Liu, Wenqing Zhang
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Root-derived long-distance signals trigger abscisic acid (ABA) synthesis and enhance drought resistance in Arabidopsis J. Genet. Genomics (IF 5.9) Pub Date : 2024-03-28 Qian-Qian Liu, Jin-Qiu Xia, Jie Wu, Yi Han, Gui-Quan Zhang, Ping-Xia Zhao, Cheng-Bin Xiang
Vascular plants have evolved intricate long-distance signaling mechanisms to cope with environmental stress, with reactive oxygen species (ROS) emerging as pivotal systemic signals in plant stress responses. However, the exact role of ROS as root-to-shoot signals in the drought response has not been determined. In this study, we reveal that compared with wild-type plants, () mutants exhibit enhanced
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Engineering the future cereal crops with big biological data: toward an intelligence-driven breeding by design J. Genet. Genomics (IF 5.9) Pub Date : 2024-03-24 Lei Liu, Jimin Zhan, Jianbing Yan
How to feed 10 billion human populations is one of the challenges that need to be addressed in the following decades, especially under an unpredicted climate change. Crop breeding, initiating from the phenotype-based selection by local farmers and developing into current biotechnology-based breeding, has played a critical role in securing the global food supply. However, regarding the changing environment
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RNAirport: a deep neural network–based database characterizing representative gene model in plants J. Genet. Genomics (IF 5.9) Pub Date : 2024-03-20 Sitao Zhu, Shu Yuan, Ruixia Niu, Yulu Zhou, Zhao Wang, Guoyong Xu
A 5′-leader, known initially as the 5′-untranslated region, contains multiple isoforms due to alternative splicings (aSs) and alternative transcription start sites (aTSSs). Therefore, a representative 5′-leader is demanded to examine the embedded RNA regulatory elements in controlling translation efficiency. Here, we develop a ranking algorithm and a deep-learning model to annotate representative 5′-leaders
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Recombination and repeat-induced point mutation landscapes reveal trade-offs between the sexual and asexual cycles of Magnaporthe oryzae J. Genet. Genomics (IF 5.9) Pub Date : 2024-03-13 Xifang Zong, Yaxin Lou, Mengshuang Xia, Kunyang Zhao, Jingxuan Chen, Ju Huang, Sihai Yang, Long Wang
The fungal disease caused by is one of the most devastating diseases that endanger many crops worldwide. Evidence shows that sexual reproduction can be advantageous for fungal diseases as hybridization facilitates host-jumping. However, the pervasive clonal lineages of observed in natural fields contradict this expectation. A better understanding of the roles of recombination and the fungi-specific
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The characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts J. Genet. Genomics (IF 5.9) Pub Date : 2024-03-11 Tongyu Zhang, Yingxi Zhu, Xiaochen Wang, Danyang Chong, Haiquan Wang, Dandan Bu, Mengfei Zhao, Lei Fang, Chaojun Li
In mammals, the neonatal heart can regenerate upon injury within a short time after birth, while adults lose this ability. Metabolic reprogramming has been demonstrated to be critical for cardiomyocyte proliferation in the neonatal heart. Herein, we reveal that cardiac metabolic reprogramming could be regulated by altering global protein lactylation. Through performing 4D label-free proteomics and
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Weakened tanning ability is an important mechanism for evolutionary skin lightening in East Asians J. Genet. Genomics (IF 5.9) Pub Date : 2024-03-08 Youwei Pu, Siyu Pu, Yanyan Chen, Qinghong Kong, Xuyang Liu, Qi Zhao, Ke Xu, Jiuming Liu, Mengyuan Li, Xiaoyu Xu, Xiaoyang Qiao, Bing Su, Jing Chen, Zhaohui Yang
The evolution of light-skin pigmentation among Eurasians is considered as an adaptation to the high-latitude environments. East Asians are ideal populations for studying skin color evolution because of the complex environment of East Asia. Here, we reported a strong selection signal for the pigmentation gene in light-skinned Han Chinese individuals. The intron mutation rs10778203 in was enriched in
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Constructing the metabolic network of wheat kernels based on structure-guided chemical modification and multi-omics data J. Genet. Genomics (IF 5.9) Pub Date : 2024-03-06 Zhitao Tian, Jingqi Jia, Bo Yin, Wei Chen
Metabolic network construction plays a pivotal role in unraveling the regulatory mechanism of biological activities, although it often proves to be challenging and labor-intensive, particularly with non-model organisms. In this study, we develop a computational approach that employs reaction models based on structure-guided chemical modification and related compounds to construct a metabolic network
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Fulminant myocarditis induced by SARS-CoV-2 infection without severe lung involvement: insights into COVID-19 pathogenesis J. Genet. Genomics (IF 5.9) Pub Date : 2024-03-04 Han Du, Zhongtao Du, Liang Wang, Hong Wang, Mingjun Jia, Chunge Zhang, Yun Liu, Cheng Zhang, Ya Zhang, Ruifeng Zhang, Shuang Zhang, Ning Zhang, Zhenghai Ma, Chen Chen, Wenjun Liu, Hui Zeng, George F. Gao, Xiaotong Hou, Yuhai Bi
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often leads to pulmonary complications. Cardiovascular sequelae, including myocarditis and heart failure, have also been reported. Here, the study presents two fulminant myocarditis cases infected by SARS-CoV-2 exhibiting remarkable elevation of cardiac biomarkers without significant pulmonary injury, as determined by imaging examinations
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Reconstruct recent multi-population migration history by using identical-by-descent sharing J. Genet. Genomics (IF 5.9) Pub Date : 2024-02-27 Wenxiao Zhang, Kai Yuan, Ru Wen, Haifang Li, Xumin Ni
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shinyTempSignal: an R shiny application for exploring temporal and other phylogenetic signals J. Genet. Genomics (IF 5.9) Pub Date : 2024-02-26 Li Zhan, Xiao Luo, Wenqin Xie, Xuan-An Zhu, Zijing Xie, Jianfeng Lin, Lin Li, Wenli Tang, Rui Wang, Lin Deng, Yufan Liao, Bingdong Liu, Yantong Cai, Qianwen Wang, Shuangbin Xu, Guangchuang Yu
The molecular clock model is fundamental for inferring species divergence times from molecular sequences. However, its direct application may introduce significant biases due to sequencing errors, recombination events, and inaccurately labeled sampling times. Improving accuracy necessitates rigorous quality control measures to identify and remove potentially erroneous sequences. Furthermore, while
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From molecule to cell: the expanding frontiers of plant immunity J. Genet. Genomics (IF 5.9) Pub Date : 2024-02-26 Lei Li, Jing Liu, Jian-Min Zhou
In recent years, the field of plant immunity has witnessed remarkable breakthroughs. During the co-evolution between plants and pathogens, plants have developed a wealth of intricate defense mechanisms to safeguard their survival. Newly identified immune receptors have added unexpected complexity to the surface and intracellular sensor networks, enriching our understanding of the ongoing plant–pathogen
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The non-canonical poly(A) polymerase FAM46C promotes erythropoiesis J. Genet. Genomics (IF 5.9) Pub Date : 2024-02-24 Ke Yang, Tianqi Zhu, Jiaying Yin, Qiaoli Zhang, Jing Li, Hong Fan, Gaijing Han, Weiyin Xu, Nan Liu, Xiang Lv
The post-transcriptional regulation of mRNA is a crucial component of gene expression. The disruption of this process can have detrimental effects on normal development and give rise to various diseases. The search for novel post-transcriptional regulators and the exploration of their roles are essential for understanding development and disease. Through a multimodal analysis of red blood cell trait
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Sensing of membrane tensions: the pleiotropic functions of OSCA/TMEM63 mechanosensitive ion channels J. Genet. Genomics (IF 5.9) Pub Date : 2024-02-16 Bo Yu, Alex Costa, Yang Zhao
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Caudal hematopoietic tissue supports definitive erythrocytes via epoa and is dispensable for definitive neutrophils J. Genet. Genomics (IF 5.9) Pub Date : 2024-02-13 Zhujuan Huang, Yongtai Xu, Zhongkai Qiu, Yunyun Jiang, Jiaye Wu, Qing Lin, Sicong He, Jianan Y. Qu, Jiahao Chen, Jin Xu
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Genetic and molecular mechanisms of reproductive isolation in the utilization of heterosis for breeding hybrid rice J. Genet. Genomics (IF 5.9) Pub Date : 2024-02-05 Chaolong Wang, Xiaowen Yu, Jian Wang, Zhigang Zhao, Jianmin Wan
Heterosis, also known as hybrid vigor, is commonly observed in rice crosses. The hybridization of rice species or subspecies exhibits robust hybrid vigor, however, the direct harnessing of this vigor is hindered by reproductive isolation. Here, we review recent advances in the understanding of the molecular mechanisms governing reproductive isolation in inter-subspecific and inter-specific hybrids
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Epigenetic variation in maize agronomical traits for breeding and trait improvement J. Genet. Genomics (IF 5.9) Pub Date : 2024-02-03 Daolei Zhang, Yujun Gan, Liang Le, Li Pu
Epigenetics-mediated breeding (Epibreeding) involves engineering crop traits and stress responses through targeted manipulation of key epigenetic features to enhance agricultural productivity. While conventional breeding methods raise concerns about reduced genetic diversity, epibreeding propels crop improvement through epigenetic variations that regulate gene expression, ultimately impacting crop
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Genetic basis of geographical differentiation, breeding selection, domestication effects, and breeding application for TaJAZ1 in wheat J. Genet. Genomics (IF 5.9) Pub Date : 2024-02-01 Botao Ye, Yangyang Liu, Ziying Wang, Liping Shen, Changbin Yin, Kuocheng Shen, Jiaqiang Sun, Xiaowan Xu, Mengjing Sun, Jianhui Wu, Zhonghu He, Xuchang Yu, Fei Lu, Yuanfeng Hao, Zifeng Guo
Abstract not available
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Genome-wide assessment of CNVs provides new insights into production and adaptive traits in Chinese indigenous sheep J. Genet. Genomics (IF 5.9) Pub Date : 2024-01-26 Meilin Jin, Gang Liu, Jian Lu, Zhiqiang Chen, Huihua Wang, Taotao Li, Caihong Wei
Abstract not available
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Aagab is required for zebrafish larval development by regulating neural activity J. Genet. Genomics (IF 5.9) Pub Date : 2024-01-20 Shihui Ding, Tursunjan Aziz, Anming Meng, Shunji Jia
Clathrin-mediated endocytosis has been implicated in various physiological processes, including nutrient uptake, signal transduction, synaptic vesicle recycling, maintenance of cell polarity, and antigen presentation. Despite prior knowledge of its importance as a key regulator in promoting clathrin-mediated endocytosis, the physiological function of α− and γ−adaptin binding protein (aagab) remains
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Journal of Genetics and Genomics in 2023: progresses and beyond J. Genet. Genomics (IF 5.9) Pub Date : 2024-01-16 Xiu-Fen Song, Xiaoxuan Guo, Jing Zhao, Yutian Zhang, Yuan Qin, Jianru Zuo
Abstract not available
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Corrigendum to ‘The power of “controllers”: Transposon-mediated duplicated genes evolve towards neofunctionalization’ [Journal of Genetics and Genomics (2023) 50, 462–472] J. Genet. Genomics (IF 5.9) Pub Date : 2024-01-16 Huijing Ma, Mengxia Wang, Yong E. Zhang, Shengjun Tan
Abstract not available
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Genome engineering of the human gut microbiome J. Genet. Genomics (IF 5.9) Pub Date : 2024-01-12 Linggang Zheng, Juntao Shen, Ruiyue Chen, Yucan Hu, Wei Zhao, Elaine Lai-Han Leung, Lei Dai
The human gut microbiome, a complex ecosystem, significantly influences host health, impacting crucial aspects such as metabolism and immunity. To deepen our comprehension and control of the molecular mechanisms orchestrating the intricate interplay between gut commensal bacteria and human health, the exploration of genome engineering for gut microbes is a promising frontier. Nevertheless, the complexities
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ERβ-activated LINC01018 promotes endometriosis development by regulating the CDC25C/CDK1/CyclinB1 pathway J. Genet. Genomics (IF 5.9) Pub Date : 2024-01-14 Ruihui Lu, Jingwen Zhu, Xin Li, Cheng Zeng, Yan Huang, Chao Peng, Yingfang Zhou, Qing Xue
Endometriosis refers to as an estrogen-dependent disease. Estrogen receptor β (ERβ), the main estrogen receptor subtype which is encoded by the estrogen receptor 2 () gene, can mediate the action of estrogen in endometriosis. Although selective estrogen receptor modulators can target the ERβ, they are not specific due to the wide distribution of ERβ. Recently, long noncoding RNAs have been implicated
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CircPTEN-MT from PTEN regulates mitochondrial energy metabolism J. Genet. Genomics (IF 5.9) Pub Date : 2024-01-05 Danhui Ruan, Jiancheng Xu, Yang Liu, Juan Luo, Xuyang Zhao, Yuhua Li, Guangxi Wang, Jiawen Feng, Hui Liang, Yue Yin, Jianyuan Luo, Yuxin Yin
PTEN is a multifunctional gene that is involved in a variety of physiological and pathological processes. Circular RNAs (circRNAs) are generated from back-splicing events during mRNA processing and participate in cell biological processes through binding to RNAs or proteins. However, PTEN-related circRNAs are largely unknown. Here we report that circPTEN-MT (hsa_circ_0002934) is a circular RNA encoded
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Exploring noncoding variants in genetic diseases: from detection to functional insights J. Genet. Genomics (IF 5.9) Pub Date : 2024-01-04 Ke Wu, Fengxiao Bu, Yang Wu, Gen Zhang, Xin Wang, Shunmin He, Mo-Fang Liu, Runsheng Chen, Huijun Yuan
Previous studies on genetic diseases predominantly focused on protein-coding variations, overlooking the vast noncoding regions in the human genome. The development of high-throughput sequencing technologies and functional genomics tools has enabled the systematic identification of functional noncoding variants. These variants can impact gene expression, regulation, and chromatin conformation, thereby
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RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium J. Genet. Genomics (IF 5.9) Pub Date : 2024-01-03 Ting Hu, Lan Liu, He Wang, Mei Yang, Bocheng Xu, Hanbing Xie, Ziyuan Lin, Xiaolei Jin, Ping Wang, Yanyan Liu, Huaqin Sun, Shanling Liu
Noncompaction of the ventricular myocardium (NVM), the third most diagnosed cardiomyopathy, is characterized by prominent trabeculae and intratrabecular recesses. However, the genetic etiology of 40–60% of NVM cases remains unknown. We identified two infants with NVM, in a nonconsanguineous family, with a typical clinical presentation of persistent bradycardia since the prenatal period. A homozygous
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CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy J. Genet. Genomics (IF 5.9) Pub Date : 2023-12-29 Yan Shi, Chunyan Cao, Yiheng Zeng, Yuanliang Ding, Long Chen, Fuze Zheng, Xuejiao Chen, Fanggui Zhou, Xiefeng Yang, Jinjing Li, Liuqing Xu, Guorong Xu, Minting Lin, Hiroyuki Ishiura, Shoji Tsuji, Ning Wang, Zhiqiang Wang, Wanjin Chen, Kang Yang
CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with leukoencephalopathy. However, since only three patients from a single family were reported, it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/NUTM2B-AS1. Here, using repeat-primed PCR and long-read sequencing, we identify
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The m6A reader YTHDC2 maintains visual function and retinal photoreceptor survival through modulating translation of PPEF2 and PDE6B J. Genet. Genomics (IF 5.9) Pub Date : 2023-12-28 Yeming Yang, Xiaoyan Jiang, Junyao Chen, Lu Liu, Guo Liu, Kuanxiang Sun, Wenjing Liu, Xianjun Zhu, Qiuyue Guan
Inherited retinal dystrophies (IRDs) are major causes of visual impairment and irreversible blindness worldwide, while the precise molecular and genetic mechanisms are still unexclusive. N6-methyladenosine (m6A) modification is the most prevalent internal modification in eukaryotic mRNA. YTH domain containing 2 (YTHDC2), an m6A reader protein, has recently been identified as a key player in germline
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TMEM63B regulates postnatal development of cochlear sensory epithelia via thyroid hormone signaling J. Genet. Genomics (IF 5.9) Pub Date : 2023-12-27 Chang Ye, Tian-Zi Zhang, Yan-Yu Zang, Yun Stone Shi, Guoqiang Wan
Abstract not available
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NCAD v1.0: a database for non-coding variant annotation and interpretation J. Genet. Genomics (IF 5.9) Pub Date : 2023-12-23 Xiaoshu Feng, Sihan Liu, Ke Li, Fengxiao Bu, Huijun Yuan
The application of whole genome sequencing is expanding in clinical diagnostics across various genetic disorders, and the significance of non-coding variants in penetrant diseases is increasingly being demonstrated. Therefore, it is urgent to improve the diagnostic yield by exploring the pathogenic mechanisms of variants in non-coding regions. However, the interpretation of non-coding variants remains
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Pan-genome analysis reveals a highly plastic genome and extensive secreted protein polymorphism in Puccinia striiformis f. sp. Tritici J. Genet. Genomics (IF 5.9) Pub Date : 2023-12-20 Jierong Wang, Yuxi Peng, Yiwen Xu, Zhiru Li, Gangming Zhan, Zhensheng Kang, Jing Zhao
Abstract not available
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enOsCas12f1-mediated exon skipping for Duchenne muscular dystrophy therapy in humanized mouse model J. Genet. Genomics (IF 5.9) Pub Date : 2023-12-14 Ming Jin, Jiajia Lin, Yu Zhang, Qingquan Xiao, Xiangfeng Kong, Xiumei Zhang, Zhurui Shao, Yin Wang, Yuyang Yu, Jinjing Li, Wan-jin Chen, Guoling Li, Hui Yang, Ning Wang
Abstract not available
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Wide hybridizations reveal the robustness of functional centromeres in Triticum-Aegilops species complex lines J. Genet. Genomics (IF 5.9) Pub Date : 2023-12-07 Yuhong Huang, Qinghua Shi, Chen Zhou, Chunhui Wang, Yang Liu, Congyang Yi, Handong Su, Fangpu Han
Abstract not available
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Characterizing structural variants based on graph-genotyping provides insights into pig domestication and local adaption J. Genet. Genomics (IF 5.9) Pub Date : 2023-12-04 Xin Li, Quan Liu, Chong Fu, Mengxun Li, Changchun Li, Xinyun Li, Shuhong Zhao, Zhuqing Zheng
Structural variants (SVs), such as deletions (DELs) and insertions (INSs), contribute substantially to pig genetic diversity and phenotypic variation. Using a library of SVs discovered from long-read primary assemblies and short-read sequenced genomes, we map pig genomic SVs with a graph-based method for re-genotyping SVs in 402 genomes. Our results demonstrate that those SVs harboring specific trait-associated
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Drosophila adhesion GPCR Remoulade regulates axon growth, branching, and guidance by modulating Rac1 GTPase J. Genet. Genomics (IF 5.9) Pub Date : 2023-12-02 Xi Yang, Changkun Pan, Meitong Ye, Jinshuo Liang, Haoyang Cheng, Qing Liang, Shu Huang, Jianshu Wang, Hoi Yee Chow, Haihuai He
Abstract not available
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Grow rice under sunshine of Xizang/Tibet: promise and challenges J. Genet. Genomics (IF 5.9) Pub Date : 2023-11-20 Chunkun Fan, Xiaoming Zheng, Qingbo Yuan, Tao Wang, Qian Qian, Qingyun Bu, Fan Chen
Abstract not available
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Metagenomics analysis identifies oral Streptococcus as potential biomarkers for nasopharyngeal carcinoma J. Genet. Genomics (IF 5.9) Pub Date : 2023-11-15 Yanmin Liu, Chengtao Wang, Lixiang Xie, Shuling Du, Li Ding, Ying Cui, Runzhi Chen, Jingxiang Zhang, Wan Wang, Xi Liu, Yan Wang, Shiyan Chen, Tian Tan, Qiaochu Zhao, Limei Yin, Chunwei Li, Yong Chen, Tao Ding
Abstract not available
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Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C. elegans J. Genet. Genomics (IF 5.9) Pub Date : 2023-11-10 Xiao Zang, Qi Wang, Hanxin Zhang, Yiyan Zhang, Zi Wang, Zixing Wu, Di Chen
The highly conserved target of rapamycin (TOR) pathway plays an important role in aging across species. Previous studies have established that inhibition of the TOR complex 1 (TORC1) significantly extends lifespan in C. elegans. However, it has not been clear whether TORC1 perturbation affects aging in a spatiotemporal manner. Here we applied the auxin-inducible degradation (AID) tool to knockdown
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Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish J. Genet. Genomics (IF 5.9) Pub Date : 2023-11-08 Ao Zhang, Jingao Lu, Shachuan Feng, Huapeng Yu, Tao Yu, Shizheng Zhao, Kemin Chen, Zhibin Huang, Jin Xu, Jianan Y. Qu, Zilong Wen
Abstract not available
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Corrigendum to “CRISPR-detector: fast and accurate detection, visualization, and annotation of genome-wide mutations induced by genome editing events” [Journal of Genetics and Genomics (2023) 563–572] J. Genet. Genomics (IF 5.9) Pub Date : 2023-10-28 Lei Huang, Dan Wang, Haodong Chen, Jinnan Hu, Xuechen Dai, Chuan Liu, Anduo Li, Xuechun Shen, Chen Qi, Haixi Sun, Dengwei Zhang, Tong Chen, Yuan Jiang
Abstract not available
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Two ABCI family transporters, OsABCI15 and OsABCI16, are involved in grain-filling in rice J. Genet. Genomics (IF 5.9) Pub Date : 2023-10-31 Bin Ma, Xiubiao Cao, Xiaoyuan Li, Zhong Bian, Qi-Qi Zhang, Zijun Fang, Jiyun Liu, Qun Li, Qiaoquan Liu, Lin Zhang, Zuhua He
Seed development is critical for plant reproduction and crop yield, with panicle seed-setting rate, grain-filling, and grain weight being key seed characteristics for yield improvement. However, few genes are known to regulate grain-filling. Here, we identify two ABCI-type transporter genes, OsABCI15 and OsABCI16, involved in rice grain-filling. Both genes are highly expressed in developing seeds,
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Epigenetic and transcriptional landscapes during cerebral cortex development in a microcephaly mouse model J. Genet. Genomics (IF 5.9) Pub Date : 2023-11-01 Qing Yang, Qiang Cao, Yue Yu, Xianxin Lai, Jiahao Feng, Xinjie Li, Yinan Jiang, Yazhou Sun, Zhong-Wei Zhou, Xin Li
The cerebral cortex is a pivotal structure integral to advanced brain functions within the mammalian central nervous system. DNA methylation and hydroxymethylation play important roles in regulating cerebral cortex development. However, it remains unclear whether abnormal cerebral cortex development, such as microcephaly, could rescale the epigenetic landscape, potentially contributing to dysregulated
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The Os14-3-3 family genes regulate grain size in rice J. Genet. Genomics (IF 5.9) Pub Date : 2023-10-31 Yingying Song, Huaizhou Yang, Wenran Zhu, Huili Wang, Juncheng Zhang, Yibo Li
Abstract not available
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Two diversities meet in the rhizosphere: root specialized metabolites and microbiome J. Genet. Genomics (IF 5.9) Pub Date : 2023-10-23 Xiaochen Wang, Jingying Zhang, Xinjun Lu, Yang Bai, Guodong Wang
Plants serve as rich repositories of diverse chemical compounds collectively referred to as specialized metabolites (SMs). These compounds are of importance for adaptive processes, including interactions with various microbes both beneficial and harmful. Considering microbes as bioreactors, the chemical diversity undergoes dynamic changes when root-derived specialized metabolites (RSMs) and microbes
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Humoral and cellular immunity against diverse SARS-CoV-2 variants J. Genet. Genomics (IF 5.9) Pub Date : 2023-10-19 Changxu Chen, Xin Wang, Zeli Zhang
Since the outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, the virus has rapidly spread worldwide. This has led to an unprecedented global pandemic, marked by millions of COVID-19 cases and a significant number of fatalities. Over a relatively short period, several different vaccine platforms are developed and deployed
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Improvement of wheat drought tolerance through editing of TaATX4 by CRISPR/Cas9 J. Genet. Genomics (IF 5.9) Pub Date : 2023-10-16 Zhongxue Wang, Yifang Zhang, Zhensheng Kang, Hude Mao
Abstract not available
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Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people inferred from 500 whole-genome data from 39 populations J. Genet. Genomics (IF 5.9) Pub Date : 2023-10-11 Yuntao Sun, Mengge Wang, Qiuxia Sun, Yan Liu, Shuhan Duan, Zhiyong Wang, Yunyu Zhou, Jun Zhong, Yuguo Huang, Xinyu Huang, Qingxin Yang, Xiangping Li, Haoran Su, Yan Cai, Xiucheng Jiang, Jing Chen, Jiangwei Yan, Shengjie Nie, Liping Hu, Junbao Yang, Guanglin He
Tibeto-Burman (TB) people have endeavored to adapt to the hypoxic, cold, and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic period. However, the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people, as well as their interaction mechanism remain unknown. We generate
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Triticeae-BGC: a web-based platform for detecting, annotating and evolutionary analysis of biosynthetic gene clusters in Triticeae J. Genet. Genomics (IF 5.9) Pub Date : 2023-10-06 Mingxu Li, Haoyu Wang, Shilong Tian, Yan Zhu, Yijing Zhang
Abstract not available
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The genome-wide meiotic recombination landscape in ciliates and its implications for crossover regulation and genome evolution J. Genet. Genomics (IF 5.9) Pub Date : 2023-10-04 Lu Fu, Chen Gu, Kazufumi Mochizuki, Jie Xiong, Wei Miao, Guangying Wang
Meiotic recombination is essential for sexual reproduction and its regulation has been extensively studied in many taxa. However, genome-wide recombination landscape has not been reported in ciliates and it remains unknown how it is affected by the unique features of ciliates: the synaptonemal complex (SC)-independent meiosis and the nuclear dimorphism. Here, we show the recombination landscape in
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IMAGGS: a radiogenomic framework for identifying multi-way associations in breast cancer subtypes J. Genet. Genomics (IF 5.9) Pub Date : 2023-09-30 Shuyu Liang, Sicheng Xu, Shichong Zhou, Cai Chang, Zhiming Shao, Yuanyuan Wang, Sheng Chen, Yunxia Huang, Yi Guo