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Biological sex and hormonal contraceptive associations with drug cue reactivity in cannabis use disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-14 Richard J. Macatee, Mallory J. Cannon, Brandon S. Schermitzler, Thomas J. Preston, Kaveh Afshar
Biological sex differences in Cannabis Use Disorder (CUD) progression, cannabis withdrawal severity, and pharmacotherapy response have been reported, suggesting that CUD mechanisms may differ by sex. Drug cue reactivity is an established predictor of drug use behavior, but the literature on sex differences in drug cue reactivity is mixed, including in CUD. One possible moderator of sex differences
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PTSD, distress and substance use in the aftermath of October 7th, 2023, terror attacks in Southern Israel J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-13 Daniel Feingold, Yuval Neria, Dana Tzur Bitan
The October 7th, 2023, terror attacks in Israel were characterized by a scope and magnitude not previously known to Israeli citizens. The aim of this study was to examine the prevalence and correlates of posttraumatic stress disorder (PTSD), emotional distress and use of addictive substances among Israeli adults, approximately one month following the attacks. PTSD was assessed with the Posttraumatic
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Pharmacogenetic intervention improves treatment outcomes in Chinese adult men with schizophrenia J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-11 Ying Qin, Yanjing Liu, Jingwen Zhao, Yong Yang, Hui Xiang, Tianwei Gao, Chengchen Huang
To investigate the clinical application value of pharmacogenetic testing in individualized drug therapy for adult male patients with schizophrenia. A total of 186 adult patients with schizophrenia were enrolled and randomised into the pharmacogenetic (PGx) intervention group and the standard care group. In the PGx intervention group, PGx testing was performed, and the medication regimen was adjusted
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Efficacy of EMDR for early intervention after a traumatic event: A systematic review and meta-analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-11 Anna Torres-Giménez, Cristina Garcia-Gibert, Estel Gelabert, Aïda Mallorquí, Xavier Segu, Alba Roca-Lecumberri, Amparo Martínez, Yolanda Giménez, Bàrbara Sureda
Eye Movement Desensitization and Reprocessing (EMDR) is a well-established psychological therapy for the treatment of post-traumatic stress disorder, based on the recommendations of clinical practice guidelines. However, these guidelines are not as consistent in recommending EMDR interventions for the early treatment of post-traumatic symptoms. The main objective of this review is to evaluate the effectiveness
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Unveiling the hidden pathways: Exploring astrocytes as a key target for depression therapy J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-11 Ying Liu, Lu Chen, Lin Lin, Caijuan Xu, Yifan Xiong, Huiwen Qiu, Xinyu Li, Sixin Li, Hui Cao
Depressive disorders are widely debilitating psychiatric disease. Despite the considerable progress in the field of depression therapy, extensive research spanning many decades has failed to uncover pathogenic pathways that might aid in the creation of long-acting and rapid-acting antidepressants. Consequently, it is imperative to reconsider existing approaches and explore other targets to improve
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Psychiatric diagnoses, somatic disorders, and emergency dispatches among individuals who used a national suicide crisis line J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-10 Peter C. Britton, Kipling M. Bohnert, Lauren M. Denneson, Dara Ganoczy, Mark A. Ilgen
Crisis line responders initiate emergency dispatches by activating 911 or other local emergency services when individuals are determined to be at imminent risk for undesired outcomes. This study examined the association of characteristics, psychiatric diagnoses, and somatic symptoms with emergency dispatches in a national sample. Veterans Crisis Line data were used to identify contacts (i.e., calls
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Efficacy of Esketamine among patients with treatment resistant depression in a ‘real world' health-care setting in Israel J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-10 Lior Dvorak, Esther Bloemhof-Bris, Assaf Shelef, Dania Halperin, Gay Wexler, Ortal Talmon, Kfir Feffer
One in five people will likely suffer from major depressive disorder (MDD) during their life. Thirty percent of those with MDD will experience Treatment Resistant Depression (TRD), which is characterized by a failure to respond to two adequately administered trials of antidepressants. Esketamine is a rapidly acting intranasal antidepressant. Present-day Esketamine research has limited data in real-world
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Mild differences in the role of somatic symptoms in depression networks in pregnancy and postpartum: A comparison with women outside peripartum J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-09 Petra Pátková Daňsová, Edita Chvojka, Hynek Cígler, Lenka Lacinová
Depression is one of the most prevalent mental ailments in pregnancy. Many authors have discussed the appropriateness of somatic symptoms for depression assessment in pregnancy and postpartum. However, no study has examined the role of somatic symptoms in networks of pregnant and postpartum women compared to women outside peripartum. Here, we show that somatic symptoms are essential to depression assessment
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Development of a brief bedside tool to screen women sexual assault survivors for risk of persistent posttraumatic stress six months after sexual assault J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-09 Kate Walsh, Nicole Short, Yin Yao Ji, Xin Ming An, Kristen D. Witkemper, Megan Lechner, Kathy Bell, Jenny Black, Jennie Buchanan, Jeffrey Ho, Gordon Reed, Melissa Platt, Ralph Riviello, Sandra L. Martin, Israel Liberzon, Sheila A.M. Rauch, Kenneth Bollen, Samuel A. McLean
This study aims to develop and validate a brief bedside tool to screen women survivors presenting for emergency care following sexual assault for risk of persistent elevated posttraumatic stress symptoms (PTSS) six months after assault. Participants were 547 cisgender women sexual assault survivors who presented to one of 13 sexual assault nurse examiner (SANE) programs for medical care within 72 h
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Network meta-analysis of the effects of different cognitive trainings on the cognitive function of patients with mild cognitive impairment J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-09 Ji-Wei Chen, Wen-Qian Du, Kun Zhu
Examining the relationship between the responses of a number of different cognitive trainings on cognitive functioning in middle-aged and elderly patients with mild cognitive impairment. Randomized controlled experimental studies published publicly from the time of inception to October 30, 2023 were searched through Web of Science, PubMed, Embase, and Cochrane library databases. Traditional and network
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An examination of the potential core symptoms of posttraumatic stress disorder: What is integral after removing general psychopathology & distress? J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-06 Alexander Puhalla, Connor Sullivan, Kathleen Chard, Benjamin Dickstein, Charles W. Hoge
Many confirmatory factor analyses (CFA) have examined the structure of posttraumatic stress disorder (PTSD) with some suggesting increased complexity (i.e., 6+ factors), while others suggesting a more refined structure (i.e., 2-factors). These competing PTSD structures may be due to conflation of non-trauma specific symptoms that have been added overtime. However, none of these studies examined if
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Influence of CYP2C19 and CYP2D6 on side effects of aripiprazole and risperidone: A systematic review J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-06 Emma de Brabander, Kristian Kleine Schaars, Therese van Amelsvoort, The PSY-PGx Consortium, Monika Budde, Urs Heilbronner, Allan H. Young, Mario Juruena, Eduard Vieta, Natalia E. Fares-Otero, Martien J. Kas, Markus Nöthen, Alexandra Philipsen, Laura L. Kilarski, Jonathan Laatsch, Moritz J. Rossner, Sven P. Wichert, Ramona Moldovan, Noam Shomron, Thomas G. Schulze, Roger Man King Ng, Nigel Olisa, Erik
Variability in hepatic cytochrome P450 (CYP) enzymes such as 2C19 and 2D6 may influence side-effect and efficacy outcomes for antipsychotics. Aripiprazole and risperidone are two commonly prescribed antipsychotics, metabolized primarily through CYP2D6. Here, we aimed to provide an overview of the effect of CYP2C19 and CYP2D6 on side-effects of aripiprazole and risperidone, and expand on existing literature
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The capacity of cognitive tests to detect generalized anxiety disorder (GAD): A pilot study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-04 Axel Baussay, Laura Di Lodovico, Daphnee Poupon, Matthieu Doublet, Nicolas Ramoz, Philibert Duriez, Philip Gorwood
Cognitive impairment remains understudied in generalized anxiety disorder (GAD), despite the high prevalence and substantial burden associated with this disorder. We aimed to assess cognitive impairment in patients with GAD and evaluate the ability of cognitive tests to detect this disorder. Because of its high rate of comorbidity, we also examined how other anxiety disorders and current major depressive
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Incidence of post-COVID psychiatric disorders according to the periods of SARS-CoV-2 variant dominance: The LIFE study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-04 Fumiko Murata, Megumi Maeda, Keitaro Murayama, Tomohiro Nakao, Haruhisa Fukuda
This retrospective cohort study examined the incidence of post-COVID psychiatric disorders in older adults according to hospitalization status and SARS-CoV-2 variant period in Japan. Claims data, COVID-19 case-related information, and vaccination records were obtained from three Japanese municipalities. We identified individuals aged ≥65 years who had COVID-19 or other respiratory tract infection (RTI)
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Genetic influences on testosterone and PTSD J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-04 Shannon E. Cusack, Adam X. Maihofer, Daniel Bustamante, Ananda B. Amstadter, Laramie E. Duncan
Females are twice as likely to experience PTSD as compared to males. Although sex differences in prevalence are well-established, little is known about why such sex differences occur. Biological factors that vary with sex, including sex hormone production, may contribute to these differences. Considerable evidence links sex hormones, such as testosterone, to PTSD risk though less is known about the
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Sex-specific associations of plasma neutrophil gelatinase-associated lipocalin (NGAL) with cognition in patients with drug-naïve schizophrenia J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-04 Meijuan Li, Xiaoli Wang, Siying Kong, Yuying Qiu, Changyong Jiang, Wei Sun, Shu Yang, Lijie Ji, Yonghui Zhang, Jie Li
This present study aimed to investigate the sex-specific association of plasma neutrophil gelatinase-associated lipocalin (NGAL) with cognition in drug-naïve schizophrenia patients for the first time. A total of 204 participants in this study, including 137 drug-naïve schizophrenia (DNS) patients and 67 healthy controls (HCs). All participants completed the Measurements and Treatment Research to Improve
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An exploratory study of the prevalence and adverse associations of in-school traditional bullying and cyberbullying among adolescents in Connecticut J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-04 Yasna Rostam-Abadi, Elina A. Stefanovics, Zu Wei Zhai, Marc N. Potenza
Bullying, traditional or cyber, among adolescents, is a public health concern. In this study, we explored frequencies and correlates of different forms of bullying among Connecticut high-school students. Youth Risk Behavior Survey data from 2019 from Connecticut adolescents (N = 1814) were used. χ tests and survey-weighted logistic regressions examined relationships between bullying subgroups (in-school
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ADHD, sleep, chronotype and health in a large cohort of Dutch nurses J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-03 M. Michielsen, M.N. Böhmer, R.C.H. Vermeulen, J.J. Vlaanderen, A.T.F. Beekman, J.J.S. Kooij
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Circulating miR-30e-3p induces disruption of neurite development in SH-SY5Y cells by targeting ABI1, a novel biomarker for schizophrenia J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-03 Mengdi Jin, Mengtong Xie, Yane Liu, Haideng Song, Min Zhang, Weizhen Li, Xinwei Li, Ningning Jia, Lin Dong, Qingxing Lu, Fengyu Xue, Lijuan Yan, Qiong Yu
Schizophrenia (SCZ) represents a set of enduring mental illnesses whose underlying etiology remains elusive, posing a significant challenge to public health. Previous studies have shown that the neurodevelopmental process involving small molecules such as miRNA and mRNA is one of the etiological hypotheses of SCZ. We identified and verified that miR-30e-3p and ABI1 can be used as biomarkers in peripheral
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Trauma-informed behavioral supports (TIBS) for inpatient treatment of individuals who experience BPD J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-04-02 Erika R. Carr, Jane E.M. Carter, Marc Hillbrand
Trauma-Informed Behavioral Supports (TIBS) is a novel treatment approach targeting aggression against self or against others in individuals who experience borderline personality disorder (BPD). It is based on applied behavior analysis and uses a person-centered and trauma-informed framework. People with BPD hospitalized because of concerning behaviors, [aggression to others, verbal aggression (e.g
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An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-29 Divya Ramakrishnan, Luis C. Farhat, Edoardo F.Q. Vattimo, Jessica L.S. Levine, Jessica A. Johnson, Bekir B. Artukoglu, Angeli Landeros-Weisenberger, Abraham Zangen, Antoine Pelissolo, Carlos A. de B. Pereira, Christian Rück, Daniel L.C. Costa, David Mataix-Cols, David Shannahoff-Khalsa, David F. Tolin, Elham Zarean, Elisabeth Meyer, Emily R. Hawken, Eric A. Storch, Erik Andersson, Euripedes C. Miguel
Expert consensus operationalized treatment response and remission in obsessive-compulsive disorder (OCD) as a Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) reduction ≥35% and score ≤12 with ≤2 on Clinical Global Impressions Improvement (CGI-I) and Severity (CGI-S) scales, respectively. However, there has been scant empirical evidence supporting these definitions. We conducted a systematic review and
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Psychomotor retardation: What about the partial responders to magnetic transcranial stimulation in treatment resistant depression ? J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-29 Alison Robin, Véronique Thomas-Ollivier, Anne Sauvaget, Morgane Pere, Samuel Bulteau
Psychomotor retardation is a core clinical component of Major Depressive Disorder responsible for disability and is known as a treatment response marker of biological treatments for depression. Our objective was to describe cognitive and motoric measures changes during a treatment by repetitive Transcranial Magnetic Stimulation (rTMS) within the THETAD-DEP trial for treatment-resistant depression (TRD)
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Association of somatic comorbidity and treatment adherence in patients with psychotic disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-28 J. Leijala, O. Kampman, J. Suvisaari, S. Eskelinen
Increased risk for somatic comorbidity in individuals with schizophrenia has been well established. In addition, psychiatric patients with somatic illnesses are more likely to have more psychiatric readmissions. Increased burden of treatment related to chronic somatic comorbidities may be associated with lower adherence to psychiatric medication. Cross-sectional study of 275 patients with schizophrenia
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Peripheral inflammation is associated with impaired sadness recognition in euthymic bipolar patients J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-28 Chih-Yu Chang, Hui Hua Chang, Cheng Ying Wu, Ying Tsung Tsai, Tsung-Hua Lu, Wei Hung Chang, Chia-Fen Hsu, Po See Chen, Huai-Hsuan Tseng
Inflammation impairs cognitive function in healthy individuals and people with psychiatric disorders, such as bipolar disorder (BD). This effect may also impact emotion recognition, a fundamental element of social cognition. Our study aimed to investigate the relationships between pro-inflammatory cytokines and emotion recognition in euthymic BD patients and healthy controls (HCs). We recruited forty-four
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Psychological flexibility in somatic symptom and related disorders: A case control study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-28 René J.D.M. Selker, Tim Y. Koppert, Jan H. Houtveen, Rinie Geenen
A key diagnostic criterion of Somatic Symptom and related Disorders (SSD) comprises significant distress and excessive time-and-energy consuming thoughts, feelings, and behavior pertaining to somatic symptoms. This diagnostic criterion is lacking in central sensitivity syndromes (CSS), such as fibromyalgia, irritable bowel syndrome, and chronic fatigue syndrome. This strong emphasis on disturbed psychological
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Correlations between developmental trajectories of brain functional connectivity, neurocognitive functions, and clinical symptoms in patients with attention-deficit hyperactivity disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-28 Yu Na Hong, Hyunchan Hwang, Jisun Hong, Doug Hyun Han
Several studies on attention-deficit hyperactivity disorder (ADHD) have suggested a developmental sequence of brain changes: subcortico-subcortical connectivity in children, evolving to subcortico-cortical in adolescence, and culminating in cortico-cortical connectivity in young adulthood. This study hypothesized that children with ADHD would exhibit decreased functional connectivity (FC) between the
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Efficacy and safety of low-dose amisulpride versus olanzapine-fluoxetine combination in post-schizophrenic depression: A randomized controlled trial J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-28 Tathagata Biswas, Biswa Ranjan Mishra, Rituparna Maiti, Susanta Kumar Padhy, Archana Mishra
Post-schizophrenic depression (PSD) increases the morbidity, mortality, and health burden in patients with schizophrenia. However, treatment of PSD is challenging due to the lack of substantial evidence of standard clinical practice. This study was aimed at comparing the efficacy and safety of low-dose amisulpride versus olanzapine-fluoxetine combination (OFC) in PSD. This was a randomized controlled
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Borderline personality disorder and aggressive behavior: A study based on the DSM-5 alternative model J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-27 Anna Caterina Leucci, Ilaria De Giorgi, Lorenzo Pelizza, Biancamaria Bortolotti, Francesca D'Adda, Lorenzo Gammino, Sara Gibiino, Loredana Lia, Margherita Magro, Luca Pellegrini, Marco Menchetti
Unplanned reactive aggressive acts are a clinical feature of particular interest in patients with borderline personality disorder (BPD). The early identification of personality traits correlated to aggressive behavior is certainly desirable in BDP populations. This study analyzes a clinical sample of 122 adult outpatients with BPD referred to Adult Mental Health Services of the Department of Mental
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Obesity in U.S. low-income veterans:Prevalence, clinical characteristics, and homelessness J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-27 Elina A. Stefanovics, Marc N. Potenza, Jack Tsai
Obesity is associated with lower socioeconomic status. To date, however, scarce research has examined the prevalence, comorbidity, and incremental burden of obesity in relation to medical, psychiatric, functional, and homelessness measures among low-income veterans. A nationally representative sample of 1004 low-income U.S. veterans was examined. Bivariate and multivariable analyses were conducted
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Fentanyl abuse proportion in methadone maintenance treatment, and patients’ knowledge about its risks J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-27 Anat Sason, Miriam Adelson, Shaul Schreiber, Einat Peles
Fentanyl is not yet routinely monitored among methadone maintenance treatment (MMT) patients in Israel. We aimed 1. to evaluate urine fentanyl proportion changes over 3 years and characterize patients' characteristics 2. To study patients' self-report on fentanyl usage, and compare knowledge about fentanyl risk, before and following brief educational intervention. Fentanyl in the urine of all current
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The role of income and emotional engagement in the efficacy of a brief help-seeking video intervention for essential workers J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-27 Doron Amsalem, Chana T. Fisch, Melanie Wall, Jun Liu, Amit Lazarov, John C. Markowitz, Mariah LeBeau, Melissa Hinds, Kip Thompson, Thomas E. Smith, Roberto Lewis-Fernández, Lisa B. Dixon, Yuval Neria
Recently we showed that a brief video-based intervention can improve openness to help-seeking and decrease treatment-related stigma among essential workers, particularly for female and Black individuals viewing demographically matched protagonists. The current randomized controlled trial explored two additional factors which may enhance the efficacy of this intervention: known to be associated with
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Beyond imagination: Sorting out and treating psychosis in the context of autism spectrum disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-26 Camilla Gesi, Luca Giacovelli, Yacob Levin Reibman, Bernardo Dell’Osso
In the last decades, growing caseness for Autism Spectrum Disorder (ASD) has been observed, owing to the diagnostic accretion of low-impairment forms, over and above other possible causes. Unrecognized ASD is likely to be mislabeled as a psychotic disorder (PD), as people in the spectrum may show ‘pseudopsychotic’ symptoms, resembling both negative and positive symptoms. On the other hand, PDs are
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Aperiodic components and aperiodic-adjusted alpha-band oscillations in children with ADHD J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-26 Ran Chen, Wen-juan Liu, Jiu-Ju Wang, Dong-Dong Zhou, Yu-feng Wang
This study aimed to investigate the aperiodic properties and aperiodic-adjusted alpha-band oscillations in children with ADHD, focusing on the influence of different scalp regions and lateralization on these neural correlates. Sixty-two ADHD children and 52 typical developing children aged 6–12 years were enrolled. EEG recordings were made with eyes closed for a minimum of 6 min. The ‘FOOOF’ was used
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Four modeling approaches to study restrictions on everyday life and social activities due to chronic diseases with consequences of suicidal behavior J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-25 Myoungjee Jung, Kwang Ok Lee, Hae-Rim Kim, Sang-Baek Koh, Jeong-An Gim
The purpose of this study was to discover the association between disability in everyday life and social activities due to chronic diseases and suicidal ideation (SI), suicidal plan (SP), and suicidal attempt (SA) from the Korea National Health and Nutrition Examination Survey (KNHANES), considering the cross-sectional design of this study, 2016–2018 dataset. Variables for finding the associated factors
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Treatment discontinuation in pharmacological clinical trials for gambling disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-25 Samuel R. Chamberlain, Konstantinos Ioannidis, Jon E. Grant
Gambling disorder affects 0.5–2% of the population, and of those who receive treatment, dropout tends to be relatively high. Very little is known about participant-specific variables linked to treatment discontinuation/dropout in gambling disorder, especially in pharmacological clinical trial settings. Data were pooled from eight previous randomized, controlled pharmacological clinical trials conducted
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Family functioning and problematic usage of the internet in youth: A cross-sectional investigation J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-25 Christine Lochner, Gizela van den Berg, Samuel R. Chamberlain, Clara Marincowitz, Bronwyne Coetzee
Problematic usage of the internet (PUI) refers to maladaptive use of the Internet linked to functional impairment as a growing concern in many countries. Youths are often considered more vulnerable to PUI than other age groups. The relationship between PUI and family dynamics is likely bidirectional and complex, warranting further research. Using a cross-sectional study design, we aimed to determine
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Long-term mental health and resilience of the first responders in Japanese ground self-defense forces engaging body recovery after the great east Japan earthquake J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-24 Yoshikazu Maeno, Manabu Fuchikami, Koichiro Fujimaki, Israel Liberzon, Shigeru Morinobu
Handling human remains is extremely difficult and stressful task, and it can contribute to the development of stress-related mental health problems. To prevent disaster from the development of mental disorders in first responders, it will be important to elucidate factors sustaining psychological well-being following the events requiring handling of human remains. Japanese Ground Self-Defense Forces
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Quantifying depressive symptoms on incidence of common chronic diseases and multimorbidity patterns in middle-aged and elderly Chinese adults J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-23 Liping Shao, Xiaohong Zhu, Dan-Lin Li, Luying Wu, Xujia Lu, Yulong Fan, Zhengpeng Qiao, Liying Hou, Chen-Wei Pan, Chaofu Ke
Depressive symptoms are highly prevalent and increase risks of various morbidities. However, the extent to which depressive symptoms could account for incidence of these chronic conditions, in particular multimorbidity patterns, remains to be examined and quantified. For this cohort analysis, we included 9024–14,093 participants aged 45 years and older from the China Health and Retirement Longitudinal
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Relationship between stable smoking behavior and cognitive function in male schizophrenia patients J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-23 Zhongzi Ma, Zhongnv Ma
To explore the relationship between stable smoking behavior and cognitive function in male schizophrenia patients. A simple random sampling method is applied to select 120 patients with schizophrenia admitted to a hospital from August 2020 to December 2022 as the subjects. They are divided into two groups based on whether they smoked or not. Their cognitive function is evaluated using the Stroop test
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Brain iron concentration in childhood ADHD: A systematic review of neuroimaging studies J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-23 Hugo A.E. Morandini, Prue A. Watson, Parma Barbaro, Pradeep Rao
Iron deficiency may play a role in the pathophysiology of Attention Deficit/Hyperactivity Disorder (ADHD). Due to its preponderant function in monoamine catecholamine and myelin synthesis, brain iron concentration may be of primary interest in the investigation of iron dysregulation in ADHD. This study reviewed current evidence of brain iron abnormalities in children and adolescents with ADHD using
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Accelerated epigenetic aging in alcohol dependence J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-23 Toshiyuki Shirai, Satoshi Okazaki, Ikuo Otsuka, Masao Miyachi, Takaki Tanifuji, Ryota Shindo, Shohei Okada, Haruka Minami, Tadasu Horai, Kentaro Mouri, Akitoyo Hishimoto
Alcohol dependence poses a global health threat associated with aging and reduced life expectancy. Recently, aging research through deoxyribonucleic acid (DNA) methylation has gained attention. New epigenetic clocks have been developed; however, no study has investigated GrimAge components, GrimAge2 components and DunedinPACE in patients with alcohol dependence. In this study, we aimed to perform epigenetic
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Changes in BDNF methylation patterns after cognitive remediation therapy in schizophrenia: A randomized and controlled trial J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-23 Rafael Penadés, Carmen Almodóvar-Payá, Clemente García-Rizo, Victoria Ruíz, Rosa Catalán, Sergi Valero, Til Wykes, Mar Fatjó-Vilas, Bárbara Arias
Although cognitive remediation therapy (CRT) produces cognitive benefits in schizophrenia, we do not yet understand whether molecular changes are associated with this cognitive improvement. A gene central to synaptic plasticity, the , has been proposed as one potential route. This study assesses whether methylation changes following CRT-produced cognitive improvement are detected. A randomized and
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In need of a specific antibody against the oxytocin receptor for neuropsychiatric research: A KO validation study J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-22 Jon DelaCuesta-Barrutia, Shizu Hidema, Heather K. Caldwell, Katsuhiko Nishimori, Amaia M. Erdozain, Olga Peñagarikano
Antibodies are one of the most utilized tools in biomedical research. However, few of them are rigorously evaluated, as there are no accepted guidelines or standardized methods for determining their validity before commercialization. Often, an antibody is considered validated if it detects a band by Western blot of the expected molecular weight and, in some cases, if blocking peptides result in loss
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An initial test of the contrast avoidance model in bipolar spectrum disorders J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-22 Hanjoo Kim, Melvin G. McInnis, Sarah H. Sperry
The Contrast Avoidance Model suggests that individuals sensitive to negative emotional shifts use prior increases in negative affect to prevent further escalation in response to adverse situations, while the heightened negative affect amplifies positive emotional contrasts when encountering unexpected positive events. Individuals with bipolar spectrum disorders (BSDs), characterized by shifts between
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Investigating the role of alexithymia in the association between cumulative childhood maltreatment and teen dating violence victimization J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-22 Valérie Théorêt, Élizabeth Hébert, Martine Hébert
Childhood maltreatment is increasingly recognized as an important risk factor for teen dating violence (TDV) victimization. However, far too little research has studied the mechanisms that could explain this higher risk of revictimization. The present study investigated the role of alexithymia in the association between cumulative childhood maltreatment, TDV victimization occurrence and chronicity
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Letter to the editor: In-depth understanding of prolonged grief disorder: Analysis based on a development atlas J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-22 Chunfeng Xiao, Boheng Zhu, Jing Wei
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Adolescent male rats show altered gut microbiota composition associated with depressive-like behavior after chronic unpredictable mild stress: Differences from adult rats J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-22 Jie Wang, Li Fan, Teng Teng, Hongyan Wu, Xueer Liu, Bangmin Yin, Xuemei Li, Yuanliang Jiang, Jianting Zhao, Qingyuan Wu, Yi Guo, Xinyu Zhou, Peng Xie
Accumulating evidence reveals the metabolism and neurotransmitter systems are different in major depressive disorder (MDD) between adolescent and adult patients; however, much is still unknown from the gut microbiome perspective. To minimize confounding factors such as geographical location, ethnicity, diet, and drugs, we investigated the gut microbial differences between adolescent and adult male
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Reduced frontocingulate theta connectivity during emotion regulation in major depressive disorder J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-21 Saskia Steinmann, Kim Janine Tiedemann, Stephanie Kellner, Claudius M. Wellen, Moritz Haaf, Christoph Mulert, Jonas Rauh, Gregor Leicht
Cognitive reappraisal is an essential emotion regulation skill for social life and psychological health. However, individuals with major depressive disorder (MDD) cannot use this skill effectively. Successful cognitive reappraisal in healthy controls (HC) has been shown to be associated with theta activity in a frontal and subcortical network. In the present study, we investigated whether MDD patients
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The gut microbiome from middle-aged women with depression modulates depressive-like behaviors and plasma fatty acid metabolism in female middle-aged mice J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-21 Huan Yu, Wen-Mao Yang, Yi-Huan Chen, Lin Guo, Rui Li, Fen Xue, Qing-Rong Tan, Zheng-Wu Peng
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Characterizing cognitive subtypes in schizophrenia using cortical curvature J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-21 Irina Papazova, Stephan Wunderlich, Boris Papazov, Ulrike Vogelmann, Daniel Keeser, Temmuz Karali, Peter Falkai, Susanne Rospleszcz, Isabel Maurus, Andrea Schmitt, Alkomiet Hasan, Berend Malchow, Sophia Stöcklein
Cognitive deficits are a core symptom of schizophrenia, but research on their neural underpinnings has been challenged by the heterogeneity in deficits’ severity among patients.
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Age differences in acute stress and PTSD symptoms during the 2023 Israel-Hamas war: Preliminary findings J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-19 Amit Shrira, Yuval Palgi
Traumatic exposure can result in acute stress symptoms in the immediate aftermath and post-traumatic stress disorder (PTSD) symptoms that persist beyond the initial weeks. Both short-term and long-term reactions require research and clinical attention. There is considerable evidence for age differences in PTSD, and older adults frequently present lower rates of PTSD compared to young adults. Much less
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A cross-sectional study of the relationship between frequency of cannabis use and psychiatric symptoms among people seeking mental health and addiction services in Nova Scotia (2019–21) J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-18 Lu Yang, Philip G. Tibbo, Sherry H. Stewart, Patryk Simon, Michele Bullerwell, JianLi Wang
Cannabis use may be a modifiable risk factor for mental health problems; however, the role of cannabis use frequency in population seeking mental health and addiction services remains unclear. This study aimed to: 1) compare the prevalence and functional impact of psychiatric symptoms among frequent, infrequent, and non-users of cannabis; and 2) evaluate the associations between cannabis use frequency
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How do decision making and fairness mediate the relationship between involuntary hospitalisation and perceived coercion among psychiatric inpatients? J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-16 Stéphane Morandi, Benedetta Silva, Guillaume Pauli, Debora Martinez, Mizué Bachelard, Charles Bonsack, Philippe Golay
Coercion perceived by psychiatric inpatients is not exclusively determined by formal measures such as involuntary admissions, seclusion or restraint, but is also associated with patients' characteristics and professionals’ attitude. This study examined how inpatients’ involvement in the decision making process, the respect of their decision making preference, and their feeling of having been treated
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Moral injury, race-related stress and post-traumatic stress disorder in a trauma-exposed Black population J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-16 Aziz Elbasheir, Travis M. Fulton, Khaled C. Choucair, Emma C. Lathan, Briana N. Spivey, Alfonsina Guelfo, Sierra E. Carter, Abigail Powers, Negar Fani
Race-related stress (RRS) is an unrecognized source of moral injury (MI)—or the emotional and/or spiritual suffering that may emerge after exposure to events that violate deeply held beliefs. Additionally, MI has not been explored as a mechanism of risk for post-traumatic stress disorder (PTSD) in trauma-exposed civilians. We examined relations among exposure to potentially morally injurious events
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Atherosclerosis and depression: is carotid intima-media thicker in patients with depression compared to matched control individuals? A systematic review and meta-analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-16 Christian Saleh MD, Tatiani Soultana Ilia MD, Raphaela Schöpfer MSc, Ulrich Seidl MD, Jasmine Deraita MSc, Salome Todua-Lennigk MD, Johanna Lieb MD, Hrvoje Budincevic MD PhD, Maria Trzcinska MD, Knarik Hovhannisyan MD, Konstantinos A. Boviatsis MD, Fabian M. Saleh MD
Objective: To investigate if there is an association between atherosclerosis and depression by using as imaging biomarker the carotid intima media thickness (cIMT), a surrogate marker for atherosclerosis.
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Post-event rumination and social anxiety: a systematic review and meta-analysis J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-15 Elizabeth V. Edgar, Ashlyn Richards, Peter J. Castagna, Michael H. Bloch, Michael J. Crowley
Post-event rumination, the extent to which one engages in persistent, detailed, and negative thinking following social situations, serves as a risk process in the pathophysiology of social anxiety. Although a substantial body of research has assessed post-event rumination and social anxiety, this literature has produced inconsistent results. We conducted a systematic review and meta-analysis to examine
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From childhood maltreatment to intimate partner violence perpetration: A prospective longitudinal examination of the roles of executive functioning and self-esteem J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-14 Diego A. Díaz-Faes, Cathy Spatz Widom
Previous research has found that childhood maltreatment predicts increased risk for violence and partner violence and there is some evidence for poorer executive functioning and low self-esteem. To date, there have been no longitudinal studies that have examined the extent to which executive functioning and self-esteem play a role in the relationship between child maltreatment and intimate partner
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Daily vitality fluctuations in older adults with depressive symptoms: A multilevel location-scale model J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-13 Dawoon Jung, Gihun Jin, Juhee Choi, Soohyun Park, Kiho Park, Dong Gi Seo, Kee-Hong Choi
Examining the daily experiences of older adults with depression facilitates the development and application of personalized effective treatments for them. In previous clinical research on depression, traditional mean-based approaches have mainly been employed. However, the within-person residual variance as a random effect provides greater insight into the heterogeneity of daily experiences among geriatric
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Differences in the relation of binge drinking and prescription drug misuse to suicide ideation and attempts between college-aged adults and adults above the age of 25: Findings from the 2015–2019 National Survey on Drug Use and Health (NSDUH) J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-11 Andrew C. Porter, Kristiana D. Carrasquillo, Lisham Ashrafioun
To clarify the role of age in risk associated with drug misuse and binge drinking, this study examines the differential relations of binge drinking and prescription drug misuse to risk of suicidal ideation and attempts in young adults of college age (18–24) compared to those above the age of 25. We used data from the National Survey on Drug Use and Health (NSDUH) for the years 2015 through 2019 (N = 269
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Characterizing the hierarchical depression phenotype in sexually diverse individuals J. Psychiatr. Res. (IF 4.8) Pub Date : 2024-03-11 Jenna C. Alley, Daniel P. Moriarity, Matthew B. Figueroa, George M. Slavich
Sexual diverse individuals are at high risk for internalizing psychopathologies, such as depression. Understanding how symptom profiles of heterogeneous psychiatric disorders such as depression differ for sexually diverse vs. heterosexual individuals is thus critical to advance precision psychiatry and maximize our ability to effectively treat members of this population. Research has failed to consider