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Prevalence and Prognostic Role of Lymphedema in Patients with Deep Venous Thrombosis and Thrombophlebitis. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-11-29 Alexandru Grigorean,Nicole Lindenblatt,Isabelle Luchsinger,Lukas Hobohm,Stavros V Konstantinides,Thomas Münzel,Stefano Barco,Karsten Keller
Background: Deep venous thrombosis (DVT) poses a substantial disease burden. Lymphedema may present with similar symptoms making the diagnosis process more difficult. Data on the epidemiology of lymphedema are lacking. Methods: The German nationwide inpatient sample served to analyze all patients hospitalized owing to DVT and/or thrombophlebitis (referred to as DVT) of the legs in Germany between 2005
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Optimal Cut-Off Value for Detecting Breast Cancer-Related Lymphedema Using Ultrasonography. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-11-16 Seung Mi Yeo,Tae Kyung Kim,So Hyun Park,Chang-Hyung Lee
Background: We previously devised an ultrasonographic evaluation to calculate subcutaneous tissue cross-sectional area (△CSA). The reliability and accuracy of this method were demonstrated in healthy individuals and in patients with lymphedema. The purpose of this study was to estimate the optimal cut-off value of the ratio of the △CSA of the involved side (lesion side) to the contralateral side for
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Effects of Body Positioning When Assessing Lymphedema of the Lower Limb Using Bioimpedance Spectroscopy. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-10-17 Louise A Koelmeyer,Katrina Gaitatzis,Belinda Thompson,Leigh C Ward
Background: Bioimpedance spectroscopy (BIS) measurements are conventionally performed in supine position with a lead device attached to gel-backed electrodes, and more recently, with a stand-on device that uses fixed stainless-steel electrodes under the hands and feet. The aim of this study was to assess and compare BIS measurements made in supine, sitting, and standing positions using lead and stand-on
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Test-Retest Reliability of a Protocol for Assessment of Local Tissue Water in the Head and Neck Area. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-10-09 Coralie R Arends,Lisette van der Molen,Michiel W M van den Brekel,Martijn M Stuiver
Background: Lymphedema measurement is vital to select appropriate treatment and monitor its progress. Quantifying lymphedema in the head and neck area is challenging. The use of tissue dielectric constant (TDC) measurements has shown promising results in other body areas. This study aims to determine the test-retest reliability of a TDC measurement protocol developed for the head and neck area. Methods
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Application of Complete Decongestive Therapy in Patients with Secondary Bilateral Lower Limb Lymphedema after Comprehensive Treatment of Gynecological Malignant Tumor. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-10-03 Yuanli Zeng,Gaoming Liu,Zheng Peng,Jin Hu,Anhui Zhang
Objective: The purpose of this study is to investigate the effect of complete decongestive therapy (CDT), based on fluoroscopy-guided manual lymph drainage (FG-MLD), combined with intermittent pneumatic compression (IPC) on patients with secondary bilateral lower limb lymphedema after comprehensive treatment for gynecological malignant tumors. Methods: After comprehensive treatment for gynecological
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Effect of Physical Therapy on Circumference Measurement and Extremity Volume in Patients Suffering from Lipedema with Secondary Lymphedema. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-10-03 Murat Esmer,Franz Josef Schingale
Background: Lipedema is a chronic and progressive disease. Many complications can occur if the disease is not treated. The most important of these complications is lipedema with secondary lymphedema. There are very few publications about lipedema with secondary lymphedema. The aim of this study is to investigate the effect of physical therapy on lower extremity circumference and volume in patients
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Psychological Changes During Inpatient Conservative Treatment for Lymphedema. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-10-03 Hisako Hara,Haruka Minagawa,Makoto Mihara
Background: Learning self-care for lymphedema is essential for patients to maintain their quality of life; however, it is sometimes difficult and stressful. There are only few studies about the psychological changes in patients hospitalized for conservative therapy. The purpose of this study was to evaluate the psychological changes in patients admitted for conservative therapy and training in self-care
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Analysis of the Risk Factors of Breast Cancer-Related Lymphedema and Construction and Evaluation of a Prediction Model. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-09-28 Hui Li,Wei-Bo Li,Zeng-Xin Sun,Jing Yu,Pei-Yuan Lv,Chun-Xiao Li,Xiao Liang,Yin Yu,Zhen-Biao Zhao
Objective: The occurrence of breast cancer-related lymphedema (BCRL) in postoperative breast cancer survivors is described and the independent risk factors of BCRL are analyzed. A BCRL nomogram prediction model is constructed, and its effectiveness is evaluated to screen out high-risk patients with BCRL. Methods: A univariate analysis was carried out to determine the risk factors possibly related to
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Effectiveness of a Nonpneumatic Active Compression Device in Older Adults with Breast Cancer-Related Lymphedema: A Subanalysis of a Randomized Crossover Trial. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-09-20 Stanley G Rockson,Roman Skoracki
Background: A recently completed clinical trial compared a novel nonpneumatic compression device (NPCD) with a traditional advanced pneumatic compression device (APCD) for the treatment of breast cancer-related lymphedema (BCRL); the study revealed that the NPCD produced superior clinical and quality-of-life (QOL) outcomes. In this subanalysis, we sought to examine these results within the subset of
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Development of Pressure Sensors to Help Support Community Lymphedema Monitoring: A Scoping Review. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-08-14 Omnia Rajab,Emily Armstrong,Martin Ferguson-Pell
Breast cancer-related lymphedema is a condition occurring after a partial or full mastectomy, where there is a buildup of interstitial fluid in the body, particularly in the upper limb. There is a lack of at-home sensors that can help monitor the progression of lymphedema. The purpose of this scoping review is to gather relevant information on sensors for remote lymphedema monitoring. A literature
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Lymphatic Vessels Insufficiency and Focal Edema in Early Stages Noncancer-Related Lymphedema. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-08-10 Marzanna T Zaleska,Natalia E Krzesniak
Introduction: Lymph flows along the lymphatics due to spontaneous contraction. However, injury and inflammation may deteriorate lymphatic' s endothelial and muscle cells and valves. In consequence, lymphatic vessels (LVs) become insufficient. Their contraction strength and rate slow down, and then lymph flow stops. Our study aimed to investigate the changes in lymph flow in early lymphedema cases.
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Intracellular and Extracellular Water Balance in Patients with Lipedema. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-08-02 Murat Esmer,Franz Josef Schingale
Background: The presence of edema in patients with lipedema has been investigated in many studies. However, no study has been found that examines the amount of intracellular (ICF) and extracellular fluid (ECF) in these patients together. The aim of this study is to examine the amount of ICF and ECF in patients with stage 2 lipedema. Methods and Results: Twenty-four patients diagnosed with stage 2 lipedema
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Lymphatic Malformations: What Can We Learn from the Fluid. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-08-01 Stanley G Rockson
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Recent Advances in Therapeutic Modalities Against Breast Cancer-Related Lymphedema: Future Epigenetic Landscape. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-06-02 Kuo Chen,Narasimha M Beeraka,Xinliang Zhang,Mikhail Y Sinelnikov,Maria Plotnikova,Cuiping Zhao,Vijaya Basavaraj,Jin Zhang,Pengwei Lu
Background: Lymphedema is a significant postsurgical complication observed in the majority of breast cancer patients. These multifactorial etiopathogenesis have a significant role in the development of novel diagnostic/prognostic biomarkers and the development of novel therapies. This review aims to ascertain the epigenetic alterations that lead to breast cancer-related lymphedema (BCRL), multiple
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The Function of T Cell Immunity in Lymphedema: A Comprehensive Review. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-05-26 Ao Fu,Chunjun Liu
Lymphedema is a debilitating disease characterized by extremity edema, fibroadipose deposition, impaired lymphangiogenesis, and dysfunctional lymphatics, often with lymphatic injury secondary to the treatment of malignancies. Emerging evidence has shown that immune dysfunction regulated by T cells plays a pivotal role in development of lymphedema. Specifically, Th1, Th2, Treg, and Th17 cells have been
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Efficacy of Lymphaticovenular Anastomosis for Secondary Upper Extremity Lymphedema: Treatment Strategies with Effects of Compression Therapy Discontinuation and Site-Specific Evaluation of the Upper Extremity. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-05-26 Erika Hamada,Satoshi Onoda,Toshihiko Satake
Background: Lymphaticovenular anastomosis (LVA) has recently become a mainstream surgical treatment for lymphedema and is a useful treatment option in addition to conservative therapies such as compression therapy, exercise therapy, and lymphatic drainage. We performed LVA with the goal of stopping compression therapy and report the effect of LVA on secondary lymphedema of the upper extremities. Methods
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Effectiveness of Mobiderm Autofit in the Intensive Phase of Breast Cancer-Related Lymphedema Treatment: A Case Series. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-05-22 Sławomir Mazur,Dorota Szczęśniak,Hanna Tchórzewska-Korba
Background: The objective of this case series was to evaluate the effectiveness of wearing Mobiderm® Autofit compressive garment as part of the complete decongestive therapy (CDT) of upper limb lymphedema. Materials and Methods: Ten women and men with stage II breast cancer-related lymphedema underwent a CDT intensive phase for 12 days, combining Mobiderm Autofit compression garment with manual lymphatic
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Lymphoscintigraphy as a Therapeutic Guidance Tool Can Improve Manual Lymphatic Drainage for the Physical Treatment of Patients with Upper Limb Lymphedema: Randomized Clinical Trial. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-05-17 Romain Barbieux,Sabrina Doyenard,Agathe Pluska,Keoma Enciso,Mirela Mariana Roman,Olivier Leduc,Albert Leduc,Pierre Bourgeois,Steven Provyn
Background: The purpose of this study was to measure the effects of lymphoscintigraphically guided manual lymphatic drainage (LG-MLD) and to compare it with standardized manual lymphatic drainage (St-MLD). Materials and Methods: Fifty-two patients with lymphedema of the upper limb who underwent lymphoscintigraphy were randomly allocated into two groups. Following the phase of physical activity, the
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Static and Dynamic Imbalance in Patients with Breast Cancer-Related Lymphedema. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-05-17 Ozlem Karasimav,Pinar Borman,Meltem Dalyan,Elif Yalcin,Zahide Betul Eliuz,Saadet Selin Koc,Seren Turhan
Background: Breast cancer-related lymphedema (BCRL) was associated with postural imbalance, but the immature knowledge introduced debate about which component of the balance was affected by BCRL in the literature. The aim of this study was to determine the static and dynamic balance of patients with BCRL in comparison with healthy subjects. Methods and Results: This case-control designed study recruited
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Exploring Indicators of Subcutaneous Tissue Fluid Accumulation in Breast Cancer-Related Lymphedema Patients Using Fractal Analysis with Virtual Volume. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-05-16 Shiori Niwa,Fumiya Hisano,Ayana Mawaki,Keisuke Nakanishi,Sachiyo Watanabe,Atsushi Fukuyama,Toyone Kikumori,Kazuhiro Shimamoto,Kuniharu Imai,Etsuko Fujimoto,Chika Oshima
Background: Breast cancer treatment sometimes causes a chronic swelling of the arm called breast cancer-related lymphedema (BCRL). Its progression is believed to be irreversible and is accompanied by tissue fibrosis and lipidosis, so preventing lymphedema from progressing by appropriate intervention at the site of fluid accumulation at an early stage is crucial. The tissue structure can be evaluated
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Tissue Dielectric Constant and Skin Stiffness Relationships in Lower Extremity Lymphedema. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-05-12 Harvey N Mayrovitz,Elham Shams,Andrea Astudillo,Aakangsha Jain
Background: Lower extremity lymphedema or edema (LELE) may progressively transition from a state of excess tissue fluid to increased fat accumulation and collagen deposition, with tissue fibrosis and hardening. Such changes may lead to altered tissue water holding and thereby impact tissue dielectric constant (TDC). This study seeks to evaluate the relationship between TDC and tissue indentation force
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The Effect of Manual Lymph Drainage and Compression Bandaging for Stage 2 Breast Cancer-Related Lymphedema: A Randomized Controlled Trial. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-05-04 Ying Liu,Xiaoyi Zhao,Jian Song,Wowa Zhao,Ying Ge,Jinghong Guan
Aim: To explore the effect of manual lymph drainage (MLD), compression bandaging (CB), or combined decongestive therapy (CDT), including MLD and CB, on stage 2 breast cancer-related lymphedema (BCRL). Methods: Sixty women with stage 2 BCRL were enrolled. They were randomly divided into the MLD group, the CB group or the CDT group. Each group, respectively, received MLD alone, CB alone, or CDT composed
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A Prospective Preliminary Study Examining the Physiological Impact of Pneumatic Compression Dosing in the Treatment of Lower Extremity Lymphedema. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-05-04 Vaughan Keeley,Katie Riches,Leigh Ward,Peter J Franks
Background: Optimal frequency and duration of pneumatic compression device (PCD) therapy for lymphedema is undetermined. This prospective, randomized preliminary study evaluated the impact of different PCD dosing protocols on physiological and patient-reported outcomes (PROs) to estimate treatment effects, assess the responsiveness of various measurement techniques, and identify endpoints for a definitive
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A Low-Cost, Portable, and Mobile-Based Bioimpedance Lymphedema Diagnosis and Monitoring System (Mobilymph): A Validation Study. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-04-24 Syarifah Aisyah Syed Ibrahim,Fatimah Ibrahim,Nur Aishah Mohd Taib,Jongman Cho
Background: Breast cancer-related lymphedema (BCRL) is a debilitating chronic illness. Early management and prevention of disease progression rely on lymphedema monitoring and assessment. At present, lymphedema monitoring systems are costly and do not promote remote monitoring. Thus, a low-cost, portable, mobile-based bioimpedance lymphedema monitoring system (Mobilymph) was developed to ensure continuous
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Acupuncture Treatment for Breast Cancer-Related Lymphedema: A Randomized Pilot Study. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-04-20 Rosie Friedman,Anna Rose Johnson,Kathy Shillue,Aaron Fleishman,Chris Mistretta,Leo Magrini,Bao Ngoc N Tran,Stanley G Rockson,Weidong Lu,Gloria Y Yeh,Dhruv Singhal
Background: Methods of conservative management for breast cancer-related lymphedema (BCRL) are burdensome in terms of time, cost, and convenience. In addition, many patients are not candidates for surgical treatment. Preliminary results have demonstrated possible beneficial effects of acupuncture for patients with BCRL. In this small pilot study, we examined the safety and feasibility of an acupuncture
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The Appraisal of Clinical Practice Guidelines for Breast Cancer-Related Lymphedema. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-04-10 Naomi D Dolgoy,Mona M Al Onazi,Joanna F Parkinson,Haukur Gudmundsson,Lori L Radke,Liz Dennett,Kristin L Campbell,Susan R Harris,David Keast,Margaret L McNeely
Background: Approaches to screening, assessment, and treatment of breast cancer-related lymphedema (BCRL) vary widely. We evaluated overall quality of clinical practice guidelines (CPGs) for managing BCRL using the Appraisal of Guidelines for REsearch and Evaluation II (AGREE II) tool, and relevance of consensus recommendations for the Canadian health context. Methods and Results: We searched electronic
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Breast Cancer-Related Lymphedema: The Primary/Secondary Conundrum. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-04-01 Stanley G Rockson
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Lipedema: Usefulness of 3D Ultrasound Diagnostics. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-03-28 Marina Cestari
Background: To define the usefulness of three-dimensional (3D) ultrasound diagnostics for lipedema. Methods and Results: In this study, starting in May 2021, it was decided to apply 3D ultrasound diagnostics in the evaluation of the tissue in 40 patients affected with lipedema (stage I-II-III) who arrived at the Pianeta Linfedema Study Centre. Furthermore, subjects with lipohypertrophy were also included
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Screening for Breast Cancer-Related Lymphedema Development Using Extracellular Water Ratio. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-03-23 Yoshichika Yasunaga,Yuto Kinjo,Saeko Kondoh,Daisuke Yanagisawa,Shunsuke Yuzuriha,Shoji Kondoh
Background: This case-control retrospective study examined whether the extracellular water ratio (%ECW) of the upper extremity, as measured through bioelectrical impedance analysis (BIA), could be an indicator of the development and severity of breast cancer-related lymphedema (BCRL). Methods and Results: BIA was used to evaluate the changes in %ECW due to BCRL development, with the %ECW measured in
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The Prevalence of the Axillo-Inguinal Lymphatic Pathway in Lymphedema of the Extremities and Potential Therapeutic Implications. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-03-23 Helen Mackie,Belinda Thompson,Asha Heydon-White,Hiroo Suami,Robbie Blackwell,Louise Koelmeyer
Background: The axillo-inguinal (or inguino-axillary) is a compensatory lymphatic drainage pathway regularly utilized by lymphedema therapists when applying manual lymphatic drainage (MLD) for upper and lower extremity lymphedema. However, there is limited evidence of the frequency of this pathway and the characteristics of patients with lymphedema in which this pathway is present. Indocyanine green
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Early Detection of Breast Cancer-Related Lymphedema: Accuracy of Indocyanine Green Lymphography Compared with Bioimpedance Spectroscopy and Subclinical Lymphedema Symptoms. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-03-22 Atilla Soran,Fuat Baris Bengur,Wendy Rodriguez,Maria Z Chroneos,Efe Sezgin
Introduction: The reported incidences of breast cancer-related lymphedema (LE) affecting the arms vary greatly. Reason for this variability includes different diagnostic techniques used across studies. In the current study, we compared the accuracy of indocyanine green lymphography (ICG_L) and bioimpedance spectroscopy (BIS) in detecting LE before presentation of clinical signs. Methods and Results:
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YouTube as a Source of Information on Lipedema: Property, Quality, and Reliability Assessment. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-03-16 Elif Esen Özdemir,Pinar Borman,Gül Mete Civelek,Mümtaz Mutlu Umaroğlu
Background/Aim: YouTube provides information on several health-conditions including lipedema. The aim of this study was to investigate the properties, quality, and quantity of YouTube videos on lipedema. Methods: We explored YouTube using the key word lipedema and the initial top 50 videos were included to review. The properties comprising informers, target, and domains of videos covering number of
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Test-Retest Reliability of Local Tissue Water and Circumference Measurements in the Head and Neck Area of Healthy Women and Men. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-03-10 Agneta Hagren,Christina Brogårdh,Karin Johansson,Johanna Sjövall,Eva Ekvall Hansson
Background: Measurements of local tissue water and circumferences are methods to evaluate lymphedema. Knowledge about reference values and reproducibility needs, however, to be determined for the head and neck (HN) area of healthy persons before it can be used in persons with HN lymphedema. The objective of this study was to evaluate the test-retest reliability including measurement errors of local
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Therapeutic Potential of the Prolyl Hydroxylase Inhibitor Roxadustat in a Mouse Hindlimb Lymphedema Model. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-03-07 Yoshitada Hoshino,Masayuki Osawa,Emi Funayama,Kosuke Ishikawa,Takahiro Miura,Masahiro Hojo,Yuhei Yamamoto,Taku Maeda
Background: Lymphedema is an intractable disease with no curative treatment available. Conservative treatment is the mainstay, and new drug treatment options are strongly needed. The purpose of this study was to investigate the effect of roxadustat, a prolyl-4-hydroxylase inhibitor, on lymphangiogenesis and its therapeutic effect on lymphedema in a radiation-free mouse hindlimb lymphedema model. Methods
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Usefulness of 33 MHz Linear Probe in Lymphatic Ultrasound for Lymphedema Patients. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-03-07 Hisako Hara,Makoto Mihara
Background: Lymphatic ultrasound has recently been reported useful in the treatment of lymphedema. However, no conclusions have been reached regarding the best probe for lymphatic ultrasound. Methods: This was a retrospective study. Fifteen limbs of 13 patients with lymphedema in whom we could not find dilated lymphatic vessels on lymphatic ultrasound with an 18 MHz probe but later could find them
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Evaluation of Chylothorax Using Dynamic Contrast-Enhanced Magnetic Resonance Lymphangiography After Lung Cancer Surgery. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-03-07 Jooae Choe,Hyun Jung Koo,Yura Ahn,Geun Dong Lee,Dong Hyun Yang,Joon-Won Kang,Ja Eun Lee,Ji Hoon Shin
Background: To determine the role of dynamic contrast-enhanced magnetic resonance lymphangiography (DCMRL) in the management of postoperative chylothorax after lung cancer surgery. Methods and Results: Between July 2017 and November 2021, patients who developed postoperative chylothorax following pulmonary resection and mediastinal lymph node dissection were assessed and those who underwent DCMRL for
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Seasonal Variation in Upper Limb Size, Volume, Fluid Distribution, and Lymphedema Diagnosis, Following Breast Cancer Treatment. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-02-22 Jennifer Phillips,Susan Witt,Neil Piller,Susan Gordon
Background: Breast cancer-related lymphedema (BCRL) is a common complication of breast cancer treatment. Anecdotal and qualitative research suggests that heat and hot weather cause an exacerbation of BCRL; however, there is little quantitative evidence to support this. The aim of this article is to investigate the relationship between seasonal climate variation and limb size, volume, fluid distribution
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The Usefulness of a Three-Microneedle Device for Indocyanine Green Fluorescence Lymphography. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-02-21 Yusuke Endo,Masaki Sano,Takafumi Kayama,Kazunori Inuzuka,Takaaki Saito,Kazuto Katahashi,Yuta Yamanaka,Hajime Tsuyuki,Nozomu Ishikawa,Ena Naruse,Hiroya Takeuchi,Naoki Unno
Background: Indocyanine green (ICG) fluorescence lymphography is widely used to diagnose lymphedema. There is little consensus on the appropriate injection method for ICG fluorescence lymphangiography. We used a three-microneedle device (TMD) for skin injection of ICG solution and investigated its usefulness. Methods and Results: Thirty healthy volunteers were injected with ICG solution using a 27-gauge
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Cytological and Biochemical Analyses of Lymphatic Fluid from Patients with Lymphatic Malformations. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-02-13 Jie Zhou,Lei Guo,Dan Song,Jing Li,Zhuang Liu,Jiali Sun,Yanli Niu
Background: Intracystic hemorrhage from lymphangiomas is a common phenomenon in lymphatic malformations (LMs); however, little is known about the associated compositional changes in the lymphatic fluid. Materials and Methods: We prospectively collected lymphatic fluid from children with LMs. Lymphatic fluid was divided depending on the bleeding status into the bleeding and nonbleeding groups. The fluid
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Lymphedema: A Symphony of Fat and Scar. Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-02-01 Stanley G Rockson
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Complex Lymphatic Anomalies: Report on a Patient Registry Using the Latest Diagnostic Guidelines Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-01-27 Themis-Areti A. Andreoti, Sebastian Berg, Annegret Holm, Marina Angerer, Michael Oberlin, Etelka Foeldi, Iris Baumgartner, Charlotte M. Niemeyer, Jochen Rössler, Friedrich G. Kapp
Objective: Generalized lymphatic anomaly (GLA), Gorham-Stout disease (GSD), kaposiform lymphangiomatosis (KLA), and central conducting lymphatic anomaly (CCLA) are rare, multisystem lymphatic disorders, referred to as complex lymphatic anomalies (CLAs). Their etiology remains poorly understood; however, somatic activating mutations have recently been discovered, and the results of targeted treatments
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Comparison of Actual and Predicted Resting Metabolic Rate in Women with Lipedema Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-01-20 Małgorzata Jeziorek, Andrzej Szuba, Krzysztof Kujawa, Bożena Regulska-Ilow
Background: An adequate dietary energy supply is particularly important in patients with lipedema as it promotes weight and fat loss. Accurate estimation of resting metabolic rate (RMR) allows implementing a proper calorie restriction diet in patients with lipedema. Our study aimed to compare actual resting metabolic rate (aRMR) with predicted resting metabolic rate (pRMR) in women with lipedema and
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Microgravity and Lymphatics: Why Space Programs Need Lymphedema Physiology Specialists Lymphat. Res. Biol. (IF 1.4) Pub Date : 2023-01-09 Heather Hettrick, Frank Aviles
Background: The resurgence of space travel in the recent years, both through formally trained astronauts on the International Space Station and the civilian space race to send astrocivilians to Low Earth Orbit and beyond, beckons the need to understand the role of the lymphatic system and role of endothelial glycocalyx when subjected to gravitational alterations.
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Does Fear of Movement Affect Fatigue and Quality of Life in Lower Extremity Lymphedema? Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-29 Cansu Sahbaz Pirincci, Emine Cihan, Pinar Borman, Meltem Dalyan
Background: The aim of our study was to determine the causes of lower extremity kinesiophobia (whether it is biological or psychological) in individuals with lower limb lymphedema (LLL), and to compare the changes in fatigue and activities of daily living with healthy individuals.
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Physiological Roles of Lymph Flow-Mediated Nitric Oxide in Lymphatic System Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-26 Toshio Ohhashi, Yoshiko Kawai, Daisuke Maejima, Moyuru Hayashi, Tomomi Watanabe-Asaka
It is known that nitric oxide (NO) is a gas and synthesized from l-arginine by the NO synthase (NOS) in vascular endothelial cells. The diffused NO activates the guanosine monophosphate, which initiates a series of intracellular events, leading to physiological response such as vasodilation. There are three different types of NOS, namely endothelial constitutive NOS (ecNOS), neuronal NOS (nNOS), and
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Utilization of Vascular Endothelial Growth Factor-C156S in Therapeutic Lymphangiogenesis: A Systematic Review Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Antonio J. Forte, Daniel Boczar, Maria T. Huayllani, Panos Z. Anastasiadis, Sarah McLaughlin
Background: Vascular endothelial growth factor (VEGF) C156S is an engineering variant of VEGF-C that has the potential to promote lymphangiogenesis, activating on VEGF receptor (VEGFR) 3, without promoting angiogenesis (i.e., not acting on VEGFR-2). We conducted a systematic review of publications assessing the use of this growth factor in lymphedema treatment. We hypothesized that VEGF-C156S specificity
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Thyroid Hormone Ameliorates Lymphedema by Suppressing Adipogenesis in a Murine Lymphedema Model Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Jaehoon Choi, Kanghee Lee, Junhyung Kim, Woonhyeok Jeong, Taehee Jo, Hyoun Wook Lee, Young Sook Park, Sang Woo Park
Background: Exogenous supplementation of thyroid hormone could inhibit excessive fat deposition in lymphedema tissue by suppressing adipogenesis.
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Role of Subcutaneous Adipose Tissues in the Pathophysiology of Secondary Lymphedema Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Masaki Sano, Satoshi Hirakawa, Takeshi Sasaki, Kazunori Inuzuka, Kazuto Katahashi, Takafumi Kayama, Yuta Yamanaka, Hajime Tsuyuki, Yusuke Endo, Ena Naruse, Yurina Yokoyama, Kohji Sato, Katsuya Yamauchi, Hiroya Takeuchi, Naoki Unno
Background: Secondary lymphedema (LE) occurs due to the disruption of lymphatic circulation. Lymphatic fluid accumulation in subcutaneous tissues induces adipocyte proliferation. Obesity is an important risk factor for the occurrence and deterioration of LE. Although the relationship between LE and subcutaneous adipose tissue increase has been reported clinically, their pathophysiological relationship
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Lymphedema After Axillary Lymph Node Dissection in Breast Cancer: Prevalence and Risk Factors—A Single-Center Retrospective Study Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Yuki Hara, Ryota Otsubo, Shota Shinohara, Michi Morita, Sayaka Kuba, Megumi Matsumoto, Kosho Yamanouchi, Hiroshi Yano, Susumu Eguchi, Takeshi Nagayasu
Background: Lymphedema may develop when axillary lymph node dissection (ALND) injures and obstructs the lymph ducts in the upper limb. In patients with breast cancer, lymphedema is difficult to treat and can cause arm swelling, heaviness, and restricted movement. We aimed to identify the prevalence and risk factors for lymphedema after ALND in patients with breast cancer.
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Can Tissue Stiffness Measured Using Shear-Wave Elastography Represent Lymphedema in Breast Cancer? Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Dong Gyu Lee, Jang Hyuk Cho
Background: Lymphedema causes skin and subcutaneous fibrosis. However, quantitative methods for estimating the severity of fibrosis due to lymphedema have not been established. We evaluated skin stiffness using shear-wave elastography (SWE) and aimed to identify stiffness-associated factors in patients with breast cancer-related lymphedema (BCRL).
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Investigation of the Association Between Breast Cancer-Related Lymphedema and the Side Effects of Taxane-Based Chemotherapy Using Indocyanine Green Lymphography Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Hideki Tokumoto, Shinsuke Akita, Rikiya Nakamura, Naohito Yamamoto, Yoshitaka Kubota, Nobuyuki Mitsukawa
Background: Breast cancer-related lymphedema (BCRL) is a common complication. Docetaxel (DOC) and paclitaxel (PTX) have been used in taxane-based chemotherapy for breast cancer and to induce fluid retention. The purpose of this study was to investigate the association between lymphatic functionality and the side effects of taxane-based chemotherapy using indocyanine green (ICG) lymphography.
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A Comparison of Bioimpedance Spectroscopy or Tape Measure Triggered Compression Intervention in Chronic Breast Cancer Lymphedema Prevention Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Sheila H. Ridner, Mary S. Dietrich, John Boyages, Louise Koelmeyer, Elisabeth Elder, T. Michael Hughes, James French, Nicholas Ngui, Jeremy Hsu, Vandana G. Abramson, Andrew Moore, Chirag Shah
Background: This study compared rates of progression to chronic breast cancer-related lymphedema (defined as ≥ 10% arm volume change from baseline requiring complex decongestive physiotherapy [CDP]) following an intervention for subclinical lymphedema (S-BCRL) triggered by bioimpedance spectroscopy (BIS) or by tape measurement (TM).
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Validity Testing of the Head and Neck Lymphedema and Fibrosis Symptom Inventory Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Jie Deng, Barbara A. Murphy, Kenneth J. Niermann, Robert J. Sinard, Anthony J. Cmelak, Sarah L. Rohde, Sheila H. Ridner, Mary S. Dietrich
Background: Lack of reliable and valid tools significantly impacts early identification and timely treatment of lymphedema and fibrosis (LEF) in the head and neck cancer population. To address this need, we developed and reported a patient-reported outcome measure (Head and Neck Lymphedema and Fibrosis Symptom Inventory [HN-LEF SI]). This article reports the construct validity (convergent and divergent
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Prolymphangiogenic Effects of 9-cis Retinoic Acid Are Enhanced at Sites of Lymphatic Injury and Dependent on Treatment Duration in Experimental Postsurgical Lymphedema Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Gene K. Lee, David P. Perrault, Antoun Bouz, Austin J. Pourmoussa, Roy Yu, Soo Jung Kim, Daniel Gardner, Maxwell Johnson, Sun Young Park, Eun Kyung Park, Young Jin N. Seong, Sunju Lee, Eunson Jung, Dongwon Choi, Young-Kwon Hong, Alex K. Wong
Background: Patients undergoing surgical treatment for solid tumors are at risk for development of secondary lymphedema due to intraoperative lymphatic vessel injury. The damaged lymphatic vessels fail to adequately regenerate and lymphatic obstruction leads to fluid and protein accumulation in the interstitial space and chronic lymphedema develops as a result. There are currently no effective pharmacological
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Cross-Cultural Adaptation and Preliminary Validation of Upper Limb Lymphedema Quality of Life Questionnaire (ULL-27) in Italian Female Patients with Breast Cancer-Related Lymphedema Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Tonia Samela, Roberto Bartoletti, Valeria Antinone, Daniele Aloisi, Elena Sofia Papanikolaou, Chiara Quintavalle, Federica De Galitiis, Damiano Abeni, Paolo Marchetti
Purpose: Lymphedema is one of the most recurrent problems reported by breast cancer survivors, which negatively affects quality of life (QoL). The Upper Limb Lymphedema Quality of Life Questionnaire (ULL-27) is a tool that assesses the QoL in patients with breast cancer-related lymphedema. At present, an Italian adaptation does not exist. The aim of this study is to perform a preliminary cross-cultural
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Preoperative Mapping of Lymphatic Vessels by Multispectral Optoacoustic Tomography Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Lisanne Grünherz, Epameinondas Gousopoulos, Carlotta Barbon, Semra Uyulmaz, Berkan Lafci, Daniel Razansky, Andreas Boss, Pietro Giovanoli, Nicole Lindenblatt
Background: In lymphatic reconstructive surgery, visualization of lymph vessels is of paramount importance. Indocyanine green (ICG) lymphography is the current gold standard in preoperative lymphatic imaging. However, visualization of lymph vessels is often limited by an overlying dermal backflow of ICG, becoming particularly prominent in advanced lymphedema stages. Multispectral optoacoustic tomography
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Adherence to Compression Garment Wear and Associated Factors Among Patients with Breast Cancer-Related Lymphedema: A Pilot Study from a Turkish Tertiary Center Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-12-15 Nihan Erdinç Gündüz, Ebru Şahin, Banu Dilek, Hülya Ellidokuz, Elif Akalın
Background: Compression garments are the basis of the maintenance phase of the breast cancer-related lymphedema (BCRL) treatment. The aim of this study is to investigate the adherence to compression garment wear and the associated factors among patients with BCRL.
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Acute Effects of Manual Lymphatic Drainage and Compression with Exercise Therapy on Breast Lymphedema Following Breast-Conserving Surgery and Radiotherapy Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-11-24 Miray Haspolat, Elif Sakızlı Erdal, Burak Erturk, Ozge Petek Erpolat, Ilke Keser
Background: Breast lymphedema is a common complication of breast cancer treatments but there are limited studies about the treatment of breast lymphedema. The aim of this study was to investigate the acute effects of manual lymphatic drainage (MLD), compression with exercise on the local tissue water percentage, pain, and stiffness following breast-conserving surgery and radiotherapy.
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Circumferential Measurements to Calculate Lower Limb Volume in Persons with Lymphedema: What Segment Length Is to Be Recommended? Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-11-24 Charlotta Jönsson, Karin Johansson, Maria Bjurberg, Christina Brogårdh
Introduction: Circumferential measurements (CMs) every 4th cm are commonly used to assess lower limb volume (LLV), but fewer measurements would be less time-consuming. The aim of this study was therefore to establish the agreement between LLV measurements derived from CM every 4th cm (V4), 8th cm (V8), and 12th cm (V12), and to evaluate the intrarater test–retest reliability for each of the three measurement
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Lymphatic Pain in Breast Cancer Survivors Lymphat. Res. Biol. (IF 1.4) Pub Date : 2022-10-20 Katie Fitzgerald Jones, Mei Rosemary Fu, Melissa L. McTernan, Eunjung Ko, Simay Yazicioglu, Deborah Axelrod, Amber A. Guth, Christine Miaskowski, Yvette P. Conley, Lisa J. Wood, Yao Wang
Background: Breast cancer survivors who report chronic pain in the affected ipsilateral upper limb or body are nearly twice as likely to develop lymphedema. Little is known about lymphatic pain, defined as co-occurring pain and swelling in the affected ipsilateral upper limb or body. The study aimed to examine the predictors and effects of lymphatic pain on breast cancer survivors' activities of daily