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Fully human anti-B7-H3 recombinant antibodies inhibited tumor growth by increasing T cell infiltration Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-28 Lin Li, Siji Nian, Qin Liu, Bo Zhang, Wulemo Jimu, Chengwen Li, Zhanwen Huang, Qiaosen Hu, Yuanshuai Huang, Qing Yuan
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Unveiling biomarkers and therapeutic targets in IgA nephropathy through large-scale blood transcriptome analysis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-28 Ting Gan, Lu-xi Qu, Shu Qu, Yuan-yuan Qi, Yue-miao Zhang, Yan-na Wang, Yang Li, Li-jun Liu, Su-fang Shi, Ji-cheng Lv, Hong Zhang, Yi-jie Peng, Xu-jie Zhou
IgA nephropathy (IgAN) is the most prevalent form of glomerulonephritis. Unfortunately, molecular biomarkers for IgAN derived from omics studies are still lacking. This research aims to identify critical genes associated with IgAN through large-scale blood transcriptome analysis. We constructed novel blood transcriptome profiles from peripheral blood mononuclear cells (PBMCs) of 53 Chinese IgAN patients
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Urine-derived exosomes and their role in modulating uroepithelial cells to prevent hypospadias Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-28 Shibo Zhu, Jinhua Hu, Guifang Chen, Wen Fu, Jin Zhang, Wei Jia
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Peficitinib alleviated acute lung injury by blocking glycolysis through JAK3/STAT3 pathway Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-27 Wenyang Jiang, Jie Ren, Xiaochen Li, Jianjian Yang, Dan Cheng
Peficitinib is a selective Janus kinase (JAK3) inhibitor recently developed and approved for the treatment of rheumatoid arthritis in Japan. Glycolysis in macrophages could induce NOD-like receptor (NLR) family and pyrin domain-containing protein 3 (NLRP3) inflammasome activation, thus resulting in pyroptosis and acute lung injury (ALI). The aim of our study was to investigate whether Peficitinib could
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Current landscape of long COVID clinical trials Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-27 Manojit Bhattacharya, Srijan Chatterjee, Sanskriti Saxena, Shyam Sundar Nandi, Sang-Soo Lee, Chiranjib Chakraborty
Long COVID was reported as a multi-systemic condition after the infection of SARS-CoV-2, and more than 65 million people are suffering from this disease. It has been noted that around 10% of severe SARS-CoV-2 infected individuals are suffering from the enduring effects of long COVID. The symptoms of long COVID have also been noted in several mild or asymptomatic SARS-CoV-2 infected individuals. While
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Pharmacological blockade of HDAC6 attenuates cancer progression by inhibiting IL-1β and modulating immunosuppressive response in OSCC Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-27 Ashutosh Mahale, Ganesh Routholla, S. Lavanya, Pravesh Sharma, Balaram Ghosh, Onkar Prakash Kulkarni
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A novel blood-based bioassay to monitor adiponectin signaling Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-27 Abdul Hadee Lone, Jialing Tang, Angelica Pignalosa, Henry H. Hsu, Ali A. Abdul-Sater, Gary Sweeney
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Magnesium alleviates extracellular histone-induced apoptosis and defective bacterial phagocytosis in macrophages by regulating intracellular calcium signal Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-27 Tao Zhong, Sainan Chen, Ke Deng, Jianbin Guan, Jiaqi Zhang, Furong Lu, Maoyou Shichen, Ronggui Lv, Zhifeng Liu, Yong Liu, Ping Chang, Zhanguo Liu
Extracellular histones have been determined as important mediators of sepsis, which induce excessive inflammatory responses in macrophages and impair innate immunity. Magnesium (Mg), one of the essential nutrients of the human body, contributes to the proper regulation of immune function. However, no reports indicate whether extracellular histones affect survival and bacterial phagocytosis in macrophages
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Protective effect of astaxanthin on ANCA-associated vasculitis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-26 Ruo-lan Sun, Jin-chun Shang, Run-hong Han, Guang-qun Xing
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease characterized by inflammation and fibrinoid necrosis of medium and small vessels, and its pathogenesis is closely related to inflammation and oxidative stress. Astaxanthin (ATX) is a carotenoid with anti-inflammatory, antioxidant, and immunomodulatory effects. We hypothesized that ATX could play
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SFXN1-mediated immune cell infiltration and tumorigenesis in lung adenocarcinoma: A potential therapeutic target Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-26 Yanjun Li, Wenke Yang, Chaojun Liu, Shengli Zhou, Xiaozhuan Liu, Tingting Zhang, Lingzhi Wu, Xinyi Li, Jiaqiang Zhang, Enqiang Chang
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Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-26 Ying-xiang Zou, Tian-nan Xiang, Li-rong Xu, Huan Zhang, Yu-he Ma, Lu Zhang, Chun-xian Zhou, Xiao Wu, Qi-lin Huang, Biao Lei, Jing-wen Mu, Xiang-yang Qin, Xin Jiang, Yue-juan Zheng
Host-directed therapy (HDT) is a new adjuvant strategy that interfere with host cell factors that are required by a pathogen for replication or persistence. In this study, we assessed the effect of dehydrozaluzanin C-derivative (DHZD), a modified compound from dehydrozaluzanin C (DHZC), as a potential HDT agent for severe infection. LPS-induced septic mouse model and Carbapenem resistant (CRKP) infection
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Inhibition of SPARC signal by aerobic exercise to ameliorate atherosclerosis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-26 Shujuan Hu, Xiao Zhang, Yiting Ding, Xuan Liu, Ruohan Xia, Xianwang Wang
Inflammation and atherosclerosis (AS) are closely associated to Secreted Protein Acidic and Rich in Cysteine (SPARC) and its related factors. This study attempted to define the role and the potential mechanism of SPARC and its related factors in ameliorating hyperlipidemia and AS by aerobic exercise intervention. The AS rat model was established with a high-fat diet plus vitamin D3 intraperitoneal
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CIRP increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-25 Zongsheng Wu, Xu Liu, Wei Huang, Jing Chen, Songli Li, Jie Chao, Jianfeng Xie, Ling Liu, Yi Yang, Xiaojing Wu, Haibo Qiu
T helper (Th) cell imbalances have been associated with the pathophysiology of sepsis, including the Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Cold-inducible RNA-binding protein (CIRP), a novel damage-associated molecular pattern (DAMP) was reported that could induce T cell activation, and skew CD4 T cells towards a Th1 profile. However, the effect and underlying mechanisms of CIRP on Th17/Treg
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Ischemia-inhibited ferric chelate reductase 1 improves ferroptosis-mediated intestinal ischemia injury via Hippo signaling Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-25 Pengzhen Liang, Wei Xie, Xing Wang, Zhaohui Du, Chuanming Zheng, Hongchang Zhao, Zhenjie Wang, Zhong Ji
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Efficacy and safety of mesenchymal stem cell-derived microvesicles in mouse inflammatory arthritis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-25 Shixiong Wei, Chenyang Lu, Sujia Li, Qiuping Zhang, Ruijuan Cheng, ShuYue Pan, QiuHong Wu, Xueting Zhao, Xinping Tian, Xiaofeng Zeng, Yi Liu
To determine the effective and safe intravenous doses of mesenchymal stem cells (MSCs)-derived microvesicles (MVs) and to elucidate the possible causes of death in mice receiving high-dose MVs. MVs were isolated from human MSCs by gradient centrifugation. Mice with collagen-induced arthritis were treated with different doses of intravenous MVs or MSCs. Arthritis severity, white blood cell count, and
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Up-regulation of HSP90α in HDM-induced asthma causes pyroptosis of airway epithelial cells by activating the cGAS-STING-ER stress pathway Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-24 Haohua Huang, Yujie Qiao, Lanhe Chu, Cuiping Ye, Lishan Lin, Hua Liao, Xiaojing Meng, Fei Zou, Haijin Zhao, Mengchen Zou, Shaoxi Cai, Hangming Dong
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The role of FPR2-mediated ferroptosis in formyl peptide-induced acute lung injury against endothelial barrier damage and protective effect of the mitochondria-derived peptide MOTS-c Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-24 Ziang Wen, Jidan Fan, Faliang Zhan, Xiaopei Li, Ben Li, Peng Lu, Xin Yao, Zihao Shen, Zhaoyang Liu, Chufan Wang, Xiangyu Li, Wanjun Jin, Xiao Zhang, Yuanpu Qi, Xiaowei Wang, Meijuan Song
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Magnolol attenuates macrophage pyroptosis triggered by Streptococcus equi subsp. zooepidemicus Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-23 Yuxuan Liu, Meijun Lu, Qian Sun, Zheng Guo, Yongjin Lin, Shun Li, Yunfei Huang, Yajuan Li, Qiang Fu
. (SEZ) is a zoonotic bacterial pathogen that causes life-threatening infections and various diseases such as meningitis, endocarditis and pneumonia. With the use of antibiotics being severely restricted in the international community, an alternative to antibiotics is urgently needed against bacterial. In the present study, the herbal extract magnolol protected mice against SEZ infection, reflected
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Role of TRPV1 and TRPA1 in TSLP production in nasal epithelial cells Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-23 Jiani Li, Fang Wang, Cuida Meng, Dongdong Zhu
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Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-23 Luchen Zhang, Guoyang Li, Bolong Lin, Hongbin He, Rongbin Zhou, Wei Jiang
The aberrant activation of NLRP3 inflammasome contributes to pathogenesis of multiple inflammation-driven human diseases. However, the medications targeting NLRP3 inflammasome are not approved for clinic use to date. Here, we show that ascorbyl palmitate (AP), a lipophilic derivative of ascorbic acid (AA) and a safe food additive, is a potent inhibitor of NLRP3 inflammasome. Compared with AA, AP inhibited
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Citrus pectin protects mice from burn injury by modulating intestinal microbiota, GLP-1 secretion and immune response Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-23 Ji-Wei Hao, Hong-Sheng Liu, Ling-Ying Liu, Qing-Hong Zhang
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Single cell transcriptome profiling of infrapatellar fat pad highlights the role of interstitial inflammatory fibroblasts in osteoarthritis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-23 Hongxu Pu, Chenghao Gao, Yi Zou, Liming Zhao, Guanghao Li, Changyu Liu, Libo Zhao, Meng Zheng, Gaohong Sheng, Xuying Sun, Xingjie Hao, Chaolong Wang, Ximiao He, Jun Xiao
Osteoarthritis (OA) is a whole-joint disease in which the role of the infrapatellar fat pad (IFP) in its pathogenesis is unclear. Our study explored the cellular heterogeneity of IFP to understand OA and identify therapeutic targets. Single-cell and single-nuclei RNA sequencing were used to analyze 10 IFP samples, comprising 5 from OA patients and 5 from healthy controls. Analyses included differential
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Deciphering JAK/STAT signaling pathway: A multifaceted approach to tumorigenesis, progression and therapeutic interventions Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-23 Yihui Wang, Zhe Wang, Shuyu Li, Juntao Ma, Xiaoshuo Dai, Jing Lu
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Intravenous immunoglobulin protects the integrity of the intestinal epithelial barrier and inhibits ferroptosis induced by radiation exposure by activating the mTOR pathway Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-22 Jia He, Peng Jiang, Li Ma, Fengjuan Liu, Ping Fu, Xi Du, Zhenni Xu, Jun Xu, Lu Cheng, Zongkui Wang, Changqing Li, Dengqun Liu
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1-Ethoxycarbonyl-beta-carboline inhibits the M2 polarization of tumor-associated macrophages: A study based on network pharmacology and molecular docking analyses Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-22 Chenxi Cao, Jian Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Yun Kong, Caiqun Zhang
Through network pharmacology, molecular docking, molecular dynamics in combination with experimentation, we explored the mechanism whereby 1-ethoxycarbonyl-beta-carboline (EBC) regulates the M2 polarization of tumor-associated macrophages. Network pharmacology was adopted for analyzing the targets and signaling pathways related to the M2 polarization of EBC-macrophages, small molecular-protein docking
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Inhibition of MAGL attenuates Intervertebral Disc Degeneration by Delaying nucleus pulposus senescence through STING Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-22 Chunyang Fan, Jiacheng Du, Zilin Yu, Jiale Wang, Lingye Yao, Zhongwei Ji, Wei He, Yongkang Deng, Dechun Geng, Xiexing Wu, Haiqing Mao
Intervertebral disc degeneration (IVDD) stands as the primary cause of low back pain (LBP). A significant contributor to IVDD is nucleus pulposus cell (NPC) senescence. However, the precise mechanisms underlying NPC senescence remain unclear. Monoacylglycerol lipase (MAGL) serves as the primary enzyme responsible for the hydrolysis of 2-arachidonoylglycerol (2-AG), breaking down monoglycerides into
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CD155 as an emerging target in tumor immunotherapy Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-22 Jiang-Wan Wu, Ying Liu, Xing-Jie Dai, Hong-Min Liu, Yi-Chao Zheng, Hui-Min Liu
CD155 is an immunoglobulin-like protein overexpressed in almost all the tumor cells, which not only promotes proliferation, adhesion, invasion, and migration of tumor cells, but also regulates immune responses by interacting with TIGIT, CD226 or CD96 receptors expressed on several immune cells, thereby modulating the functionality of these cellular subsets. As a novel immune checkpoint, the inhibition
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Immune-related adverse events associated with first-line immune checkpoint inhibitors for metastatic renal cell carcinoma: A systematic review and network meta-analysis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-22 Shan Wang, Hongwei Lv, Jing Yu, Miao Chen
In the realm of metastatic renal cell carcinoma (mRCC), the introduction of immune checkpoint inhibitors (ICIs) has revolutionized treatment paradigms. Despite their effectiveness, the comprehensive safety profile of these therapies remains inadequately explored. This network -analysis aims to comparing the safety profiles of ICI-based treatments in mRCC, offering vital insights that could lead to
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Syringin alleviates bisphenol A-induced spermatogenic defects and testicular injury by suppressing oxidative stress and inflammation in male zebrafish Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-22 Ye Zhao, Xu Luo, Jinyuan Hu, Mogellah John Panga, Clara Appiah, Zhanxiang Du, Lin Zhu, Vladimir Retyunskiy, Xing Gao, Bo Ma, Qi Zhang
Syringin (SRG) is a bioactive principle possessing extensive activities including scavenging of free radicals, inhibition of apoptosis, and anti-inflammatory properties. However, its effects on spermatogenic defects and testicular injury as well as the underlying mechanisms are still unclear. This study aims to investigate the protective effect of SRG on testis damage in zebrafish and explore its potential
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ILC2s: Unraveling the innate immune orchestrators in allergic inflammation Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-20 Hui-Fei Lu, Yi-Chi Zhou, Dan-Dan Luo, Dun-Hui Yang, Xi-Jia Wang, Bao-Hui Cheng, Xian-Hai Zeng
The prevalence rate of allergic diseases including asthma, atopic rhinitis (AR) and atopic dermatitis (AD) has been significantly increasing in recent decades due to environmental changes and social developments. With the study of innate lymphoid cells, the crucial role played by type 2 innate lymphoid cells (ILC2s) have been progressively unveiled in allergic diseases. ILC2s, which are a subset of
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Leonurine alleviates vancomycin nephrotoxicity via activating PPARγ and inhibiting the TLR4/NF-κB/TNF-α pathway Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-20 Xuedong Yin, Qian Gao, Chensuizi Li, Qiaoling Yang, HongliangDong, Zhiling Li
Vancomycin (VCM) is the first-line antibiotic for severe infections, but nephrotoxicity limits its use. Leonurine (Leo) has shown protective effects against kidney damage. However, the effect and mechanism of Leo on VCM nephrotoxicity remain unclear. In this study, mice and HK-2 cells exposed to VCM were treated with Leo. Biochemical and pathological analysis and fluorescence probe methods were performed
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Esculin targets TLR4 to protect against LPS-induced septic cardiomyopathy Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-20 Zhenyang Su, Min Gao, Liqing Weng, Tianhua Xu
Esculin, a main active ingredient from Cortex fraxini, possesses biological activities such as anti-thrombosis, anti-inflammatory, and anti-oxidation effects. However, the effects of Esculin on septic cardiomyopathy remains unclear. This study aimed to explore the protective properties and mechanisms of Esculin in countering sepsis-induced cardiac trauma and dysfunction. In lipopolysaccharide (LPS)-induced
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Sirt1 alleviates osteoarthritis via promoting FoxO1 nucleo-cytoplasm shuttling to facilitate autophagy Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-20 Mao Xu, Zhuang Qian, Ying Zhang, Xin Gao, Zhengmin Ma, Xinxin Jin, Shufang Wu
This study aims to investigate the role and underlying mechanisms of in the pathophysiological process of OA. Safranine O and HE staining were utilized to identify pathological changes in the cartilage tissue. Immunohistochemistry was employed to evaluate the expression levels of proteins. IL-1β treatment and mice were utilized to induce OA model both and . Key autophagy-related transcription factors
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Mechanism of astragaloside IV regulating NLRP3 through LOC102555978 to attenuate cerebral ischemia reperfusion induced microglia pyroptosis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-20 Ping Gao, Haowei Shi, Xiaofei Jin, Shuhan Guo, Xiaohong Zhou, Weijuan Gao
Astragaloside IV(ASⅣ), the main component of Radix Astragali, has been used to treat cerebral ischemia reperfusion injury (CIRI). However, the molecular mechanism of ASIV in CIRI needs to be further elucidated. Long non-coding RNA (lncRNA) is considered to be an important kind of regulatory molecule in CIRI. In this work, the biological effect and molecular mechanism of ASIV in CIRI through lncRNA
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Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-20 Wenli Cheng, Luyi Tan, Susu Yu, Jia Song, Ziyin Li, Xinyue Peng, Qinzhi Wei, Zhini He, Wenjuan Zhang, Xingfen Yang
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Kimura’s disease treated with dupilumab: A case report and literature review Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-19 Si-Yu Luo, Kai-Yi Zhou, Qin-Xiao Wang, Li-Jia Deng, Sheng Fang
Kimura's disease (KD) is a rare chronic inflammatory disorder characterised by painless, deep subcutaneous nodules that most commonly affect the head and neck region of Asian men. Due to high relapse rates and side effects of current therapies, the treatment of KD is challenging. To present a case of KD that was successfully treated with dupilumab and to review the literature with a focus on the evaluation
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Fibroblast growth factor 21 mitigates lupus nephritis progression via the FGF21/Irgm 1/NLRP3 inflammasome pathway Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-19 Yimeng Zou, Dan Wang, Wenying Sun, Qing Wu, Shijie Liu, Zeheng Ren, Yanan Li, Tianqi Zhao, Zhitong Li, Xinyu Li, Weiyue Cao, Jiachi Han, Xiaochen Guo, Guiping Ren
As an endocrine cytokine, fibroblast growth factor 21 (FGF21) exhibits anti-inflammatory properties. With the development of lupus nephritis (LN), which is tightly related to pathogenic factors, including inflammation and immune cell dysregulation, we explored the impact of Fibroblast Growth Factor 21 (FGF21) as well as its underlying mechanism. We induced an LN model using pristane in both wild-type
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Identification of clinical characteristics biomarkers for rheumatoid arthritis through targeted DNA methylation sequencing Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-19 Jianan Zhao, Lingxia Xu, Kai Wei, Ping Jiang, Cen Chang, Linshuai Xu, Yiming Shi, Yixin Zheng, Yu Shan, Yuejuan Zheng, Yi Shen, Jia Liu, Shicheng Guo, Rongsheng Wang, Dongyi He
Rheumatoid arthritis (RA) is a complex disease with a challenging diagnosis, especially in seronegative patients. The aim of this study is to investigate whether the methylation sites associated with the overall immune response in RA can assist in clinical diagnosis, using targeted methylation sequencing technology on peripheral venous blood samples. The study enrolled 241 RA patients, 30 osteoarthritis
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1-Phosphate receptor agonists: A promising therapeutic avenue for ischemia-reperfusion injury management Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-19 Linyuan Wang, Xiaowen Zhang, Chunyan Ma, Nan Wu
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Serum iron element: A novel biomarker for predicting PD-1 immunotherapy efficacy Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-19 Fang Luan, Jingliang Wang, Lei Liu, Bin Liu, Fuxia Li, Jing Zhao, Jingjiang Lai, Fengxian Jiang, Wei Xu, Zhizhao Zhang, Pancen Ran, Yang Shu, Zhe Yang, Guobin Fu
This study aims to explore the relationship between serum iron by inductively coupled plasma-mass spectrometry (ICP-MS) and the efficacy of immune checkpoint inhibitors (ICIs) and potential mechanism. Totally 113 patients from 233 patients with advanced metastatic lung cancer, esophageal cancer, gastric cancer and colorectal cancer who treated with immunotherapy in Shandong Provincial Hospital were
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Dynamic ctDNA-based analysis of drug-resistant gene alterations at RAS/BRAF wild-type metastatic colorectal cancer patients after cetuximab plus chemotherapy as the first-line treatment Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-18 Yu-Wen Zhou, Xin Zhao, Lu Ni, Peng Cao, Wei-Bing Leng, Qing Zhu, Hong-Feng Gou, Jiao Zhang, Xiao-Fen Li, Meng Qiu
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Immunoenhancement effect of cinobufagin on macrophages and the cyclophosphamide-induced immunosuppression mouse model Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-18 Yue-Zhu Zhao, Yi-Lun Wang, Yang Yu
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Local thiamet-G delivery by a thermosensitive hydrogel confers ischemic cardiac repair via myeloid M2-like activation in a STAT6 O-GlcNAcylation-dependent manner Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-18 Wenjing Zhou, Qingsong Tang, Shengnan Wang, Liang Ding, Ming Chen, Hongman Liu, Yong Wu, Xiwen Xiong, Zhenya Shen, Weiqian Chen
Infarct healing requires a dynamic and orchestrated inflammatory reaction following myocardial infarction (MI). While an uncontrolled excessive inflammatory response exaggerates ischemic injury post-MI, M2-like reparative macrophages may facilitate inflammation regression and promote myocardial healing. However, how protein post-translational modification regulates post-MI cardiac repair and dynamic
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Gypenoside XLIX alleviates acute liver injury: Emphasis on NF-κB/PPAR-α/NLRP3 pathways Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-18 Mengyuan Zhou, Yu Cao, Shaocheng Xie, Yannan Xiang, Mengxin Li, Haitao Yang, Zibo Dong
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Ischemia and reperfusion-injured liver-derived exosomes elicit acute lung injury through miR-122-5p regulated alveolar macrophage polarization Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-18 Jingshu Lyu, Mingwei Sheng, Yingli Cao, Lili Jia, Chen Zhang, Yiqi Weng, Wenli Yu
Acute lung injury (ALI) is a common postoperative complication, particularly in pediatric patients after liver transplantation. Hepatic ischemia–reperfusion (HIR) increases the release of exosomes (IR-Exos) in peripheral circulation. However, the role of IR-Exos in the pathogenesis of ALI induced by HIR remains unclear. Here, we explored the role of exosomes derived from the HIR-injured liver in ALI
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Interleukin-2/anti-interleukin-2 complex attenuates inflammation in a mouse COPD model by expanding CD4+ CD25+ Foxp3+ regulatory T cells Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-18 Ruirui Duan, Ke Huang, Tao Yu, Chenli Chang, Xu Chu, Yuhang Huang, Zhoude Zheng, Linxi Ma, Baicun Li, Ting Yang
Chronic, nonspecific inflammation of the alveoli and airways is an important pathological feature of chronic obstructive pulmonary disease (COPD), while sustained inflammatory reactions can cause alveolar damage. Regulatory T cells (Tregs) inhibit inflammation, whereas the interleukin-2/anti-interleukin-2 complex (IL-2C) increases the number of Tregs; however, whether the IL-2C has a therapeutic role
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Irbesartan ameliorates diabetic nephropathy by activating the Nrf2/Keap1 pathway and suppressing NLRP3 inflammasomes in vivo and in vitro Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-18 Yuan Li, Weihong Long, Haifeng Zhang, Meng Zhao, Menghan Gao, Weiying Guo, Lu Yu
Diabetic nephropathy (DN) is characterized by albuminuria and renal dysfunction caused by diabetes. At present there is no specific treatment for DN. Irbesartan (IRB) is an angiotensin receptor inhibitor indicated for the treatment of hypertension and DN. However, the underlying molecular mechanisms of IRB on DN remains obscure. RAW264.7 macrophages were incubated in RPMI-1640, cell viability was evaluated
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Novel insights into macrophage immunometabolism in nonalcoholic steatohepatitis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-18 Yali Yuan, Ye Zhang, Xinyu Lu, Junxiang Li, Muyuan Wang, Wenji Zhang, Mengyu Zheng, Zhongmei Sun, Yunqi Xing, Yitong Li, Yingdi Qu, Yao Jiao, Haixiao Han, Chune Xie, Tangyou Mao
Nonalcoholic steatohepatitis (NASH), an inflammatory subtype of nonalcoholic fatty liver disease (NAFLD), is characterized by liver steatosis, inflammation, hepatocellular injury and different degrees of fibrosis, and has been becoming the leading cause of liver-related morbidity and mortality worldwide. Unfortunately, the pathogenesis of NASH has not been completely clarified, and there are no approved
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Biomimetic nanoparticles for effective Celastrol delivery to targeted treatment of rheumatoid arthritis through the ROS-NF-κB inflammasome axis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-18 Bo Wang, Jiquan Shen, Xinggao Wang, Ruixing Hou
Previous study has indicated that Celastrol (Cel) has various physiological and pharmacological effects, including antibacterial, antioxidant, pro-apoptotic, anticancer and anti-rheumatoid arthritis (RA) effects. However, low water solubility, low oral bioavailability, narrow treatment window, and high incidence of systemic adverse reactions still limit the further clinical application of Cel. Here
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Neutrophil accumulation raises defence against Streptococcus equi ssp. zooepidemicus in the absence of Gasdermin D Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-17 Yajuan Li, Zihua Lin, Jingyu Yu, Yuxuan Liu, Shun Li, Yunfei Huang, Oladejo Ayodele Olaolu, Qiang Fu
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Sophoricoside improved Crohn's disease-like colitis by inhibiting intestinal epithelial cell apoptosis through PI3K/AKT signaling Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Qingqing Li, Jing Li, Lixia Yin, Ju Huang, Xinyue Liu, Jinran Shi, Zhijun Geng, Xue Song, Lian Wang, Yueyue Wang, Xiaofeng Zhang, Lugen Zuo, Jianguo Hu
Increased apoptosis of intestinal epithelial cells (IECs) is a significant cause of intestinal barrier dysfunction in Crohn’s disease (CD). Sophoricoside (SOP) is an isoflavone glycoside known for its anti-apoptotic properties. The aim of this study was to investigate the effects of SOP on mice with CD-like colitis and to understand the underlying mechanisms. Mice treated with 2,4,6-trinitrobenzene
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Designing a predictive Framework: Immune-Related Gene-Based nomogram and prognostic model for kidney renal papillary cell carcinoma Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Adrian Lim, Mouad Edderkaoui, Yi Zhang, Qiang Wang, Ruoxiang Wang, Stephen J. Pandol, Yan Ou
Kidney renal papillary cell carcinoma (KIRP) is frequently associated with an unfavorable prognosis for affected individuals. Unfortunately, there has been insufficient exploration in search for a reliable prognosis signature and predictive indicators to forecast outcomes for KIRP patients. The aim of this study is to employ a comprehensive analysis of data for the identification of prognosis genes
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Targeting the “tumor microenvironment”: RNA-binding proteins in the spotlight in colorectal cancer therapy Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Yiwei Zhang, Yujun Zhang, Jingjing Song, Xifu Cheng, Chulin Zhou, Shuo Huang, Wentao Zhao, Zhen Zong, Lingling Yang
Colorectal cancer (CRC) is the third most common cancer and has the second highest mortality rate among cancers. The development of CRC involves both genetic and epigenetic abnormalities, and recent research has focused on exploring the ex-transcriptome, particularly post-transcriptional modifications. RNA-binding proteins (RBPs) are emerging epigenetic regulators that play crucial roles in post-transcriptional
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Bulk and single-cell RNA sequencing analysis with 101 machine learning combinations reveal neutrophil extracellular trap involvement in hepatic ischemia-reperfusion injury and early allograft dysfunction Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Manling Xie, Zhen He, Bing Bin, Ning Wen, Jihua Wu, Xiaoyong Cai, Xuyong Sun
Hepatic ischaemia–reperfusion injury (HIRI) is a major clinical concern during the perioperative period and is closely associated with early allograft dysfunction (EAD), acute rejection (AR) and long-term graft survival. Neutrophil extracellular traps (NETs) are extracellular structures formed by the release of decondensed chromatin and granular proteins following neutrophil stimulation. There is growing
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Protective effect of carbon dots as antioxidants on intestinal inflammation by regulating oxidative stress and gut microbiota in nematodes and mouse models Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Nannan Peng, Jingmin Wang, Haimei Zhu, Ziyue Liu, Jiayi Ren, Wenjing Li, Yongzhong Wang
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Prussian blue analogues improves the microenvironment after spinal cord injury by regulating Zn Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Jinpeng Gao, ShuRui Chen, Sen Lin, Xifan Mei
Mitochondrial injury, neuronal apoptosis and phenotypic transformation of macrophages are the main mechanisms of spinal cord injury. Based on the Prussian blue nanomase's strong ability to clear free radicals, the treatment of spinal cord injury with nano-zirconium (Pb–Zr) was carried out. The disease treatment strategy based on nanomaterials has excellent therapeutic effect, and Prussian blue analogs
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Dupilumab therapy improves gut microbiome dysbiosis and tryptophan metabolism in Chinese patients with atopic dermatitis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Liu Yang, Danqi Li, Shuomin Sun, Danping Liu, Yi Wang, Xiaohuan Liu, Bin Zhou, Wenjia Nie, Lu Li, Yifei Wang, Shanshan Sha, Yan Li, Chen Shen, Juan Tao
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Pharmacological inhibition of the ACE/Ang-2/AT1 axis alleviates mechanical ventilation-induced pulmonary fibrosis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Jinhua Feng, Xi Huang, Qiaoyi Xu, Ri Tang, Yang Zhou, Shaojie Qin, Shunpeng Xing, Yuan Gao, Shuya Mei, Zhengyu He
Mechanical ventilation (MV) is an essential therapy for acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. However, it can also induce mechanical ventilation-induced pulmonary fibrosis (MVPF) and the underlying mechanism remains unknown. Based on a mouse model of MVPF, the present study aimed to explore the role of the angiotensin-converting enzyme/angiotensin II/angiotensin type 1
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L-arginine mitigates bleomycin-induced pulmonary fibrosis in rats through regulation of HO-1/PPAR-γ/β-catenin axis Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Nabil A. Alhakamy, Abdulmohsin J. Alamoudi, Hani Z. Asfour, Osama A.A. Ahmed, Ashraf B. Abdel-Naim, Esam M. Aboubakr
Pulmonary fibrosis is a chronic and progressively deteriorating lung condition that can be replicated in laboratory animals by administering bleomycin, a chemotherapeutic antibiotic known for its lung fibrosis-inducing side effects. L-arginine, a semi-essential amino acid, is recognized for its diverse biological functions, including its potential to counteract fibrosis. This study aimed to evaluate
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Clinicopathological features and mucosal microbiota in gastric mucosal damage between nodular and non-nodular gastritis in children with Helicobacter pylori infection Int. Immunopharmacol. (IF 5.6) Pub Date : 2024-03-16 Wei Zheng, Yongjie Gan, Yaofeng Yang, Kerong Peng, Fubang Li, Hong Zhao, Weizhong Gu, Mizu Jiang
Nodular gastritis (NG) represents a frequently observed clinical presentation of () infection in pediatric patients. This investigation aimed to explore the microbiota and histological features of the gastric mucosa in children with colonized NG. The current investigation examined a sample of 120 children who underwent gastroscopy due to symptoms of gastrointestinal distress, which showed that 64 were