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Lower NKG2D expression in hepatic natural killer cells predicts poorer prognosis for chronic hepatitis B patients with cirrhosis Hum. Immunol. (IF 2.7) Pub Date : 2024-03-16 Yangqing Ma, Dabing Ping, Kai Huang, Yanyan Tao, Yuan Peng, Xin Sun, Chenghai Liu
Natural killer cells (NK) acts a central player of the immune system in liver cirrhosis. The aim of this study was to examine the expression of activating intra-hepatic NK cell group 2D (NKG2D) in patients with chronic hepatitis B (CHB) and analyzed the correlation between NKG2D expression and prognosis of liver cirrhosis in these patients. This was a cross-section study. Subjects with liver biopsy
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Suppressor T helper type 17 cell responses in intestinal transplant recipients with allograft rejection Hum. Immunol. (IF 2.7) Pub Date : 2024-03-16 Leonid Belyayev, Jiman Kang, Mohammed Sadat, Katrina Loh, Digvijay Patil, Vinona Muralidaran, Khalid Khan, Stuart Kaufman, Sukanya Subramanian, Yuriy Gusev, Krithika Bhuvaneshwar, Habtom Ressom, Rency Varghese, Udeme Ekong, Cal S. Matsumoto, Simon C. Robson, Thomas M. Fishbein, Alexander Kroemer
Intestinal transplant (ITx) rejection is associated with memory T helper type 17 cell (Th17) infiltration of grafted tissues. Modulation of Th17 effector cell response is facilitated by T regulatory (Treg) cells, but a phenotypic characterization of this process is lacking in the context of allograft rejection. Flow cytometry was performed to examine the expression of surface receptors, cytokines,
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Identification of novel HLA alleles discovered in 2022–2023 Hum. Immunol. (IF 2.7) Pub Date : 2024-03-10 Michael D Gautreaux, Elaine F. O'Shields, Eric M. Netherton, Sharlie B. Brown, Jennie W. Stewart, Kimberly N. Weavil, Hannah L. Soulé, Hayley N. Sapkota, David F. Kiger
In this paper, we describe 10 novel HLA alleles discovered, submitted and officially named in the calendar years 2022 through the end of 2023.
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Investigating viral and autoimmune T cell responses associated with post-acute sequelae of COVID-19 Hum. Immunol. (IF 2.7) Pub Date : 2024-03-02 Gregory P. Williams, Esther Dawen Yu, Kendra Shapiro, Eric Wang, Antoine Freuchet, April Frazier, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Ricardo da Silva Antunes
Post-acute sequelae of COVID-19 (PASC), or Long COVID, is a chronic condition following acute SARS-CoV-2 infection. Symptoms include exertion fatigue, respiratory issues, myalgia, and neurological manifestations such as ‘brain fog,’ posing concern for their debilitating nature and potential role in other neurological disorders. However, the underlying potential pathogenic mechanisms of the neurological
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Current approaches for risk assessment of intestinal transplant patients: A view from the histocompatibility laboratory Hum. Immunol. (IF 2.7) Pub Date : 2024-03-02 Qingyong Xu, Adriana Zeevi, Armando Ganoza, Ruy J. Cruz, George V. Mazariegos
Despite its recent decline in volumes, intestinal transplantation remains an important option for patients with irreversible intestinal failures. The long-term outcome of an intestinal transplant has stagnated. The major cause of graft loss is rejection, resulting from mismatches in human leukocyte antigens (HLA) and the presence of antibodies to mismatched donor-specific HLA antigens (DSA). Literature
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Including the liver in the visceral allograft: Impact on donor-specific anti-HLA antibodies and long-term outcomes Hum. Immunol. (IF 2.7) Pub Date : 2024-02-27 Dace Abele, Markus Gäbel, Mihai Oltean, Jonas Varkey, Johan Mölne, Nils Ekwall, Helena Borg, Hanna Jacobsson, Jan Holgersson, Gustaf Herlenius
Humoral immunity emerges as a risk factor for graft failure after visceral transplantation (VTx) and development of donor-specific anti-HLA antibodies (DSAs) has been linked with poor outcomes. In most cases, a simultaneous liver transplant can be safely performed in sensitized patients with DSA and appears protective against lymphocytotoxic antibodies. We investigated the incidence of acute (AR) and
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The increasing need for ABO blood group genotyping and quality assurance implications for laboratory implementation Hum. Immunol. (IF 2.7) Pub Date : 2024-02-23 Amena Usmani, Gerald P. Morris, Cathi Murphey
ABO blood group antigens are critical determinants of immunologic self and non-self and are ubiquitously expressed on all cellular tissues. Antibodies against non-self ABO antigens are naturally present and can mediate pathologic reactions against incompatible transfused blood cells and transplanted tissues. Laboratory testing for ABO antigens and isoagglutinins is essential for safe and effective
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The role of immune system in atherosclerosis: Molecular mechanisms, controversies, and future possibilities Hum. Immunol. (IF 2.7) Pub Date : 2024-02-18 Tianle Zhang, Chenxu Pang, Mengxin Xu, Qianqian Zhao, Zhijie Hu, Xijuan Jiang, Maojuan Guo
Numerous cardiovascular disorders have atherosclerosis as their pathological underpinning. Numerous studies have demonstrated that, with the aid of pattern recognition receptors, cytokines, and immunoglobulins, innate immunity, represented by monocytes/macrophages, and adaptive immunity, primarily T/B cells, play a critical role in controlling inflammation and abnormal lipid metabolism in atherosclerosis
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A comprehensive review on the role of T cell subsets and CAR-T cell therapy in Aspergillus fumigatus infection Hum. Immunol. (IF 2.7) Pub Date : 2024-02-13 Abozar Nasiri-Jahrodi, Mehdi Barati, Hasan Namdar Ahmadabad, Hamid Badali, Hamid Morovati
Understanding the immune response to , a common cause of invasive fungal infections (IFIs) in immunocompromised individuals, is critical for developing effective treatments. Tcells play a critical role in the immune response to , with different subsets having distinct functions. Th1 cells are important for controlling fungal growth, while Th2 cells can exacerbate infection. Th17 cells promote the clearance
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Differences in hidradenitis suppurativa patterns of cutaneous involvement between sexes: Insights from a cross-sectional study Hum. Immunol. (IF 2.7) Pub Date : 2024-02-06 Dillon Mintoff, Nikolai P. Pace
Hidradenitis suppurativa is a chronic, inflammatory condition of the pilosebaceous unit in which patients manifest multiple, painful cutaneous nodules, abscesses and tunnels. These lesions are described to affect the intertriginous zones, however, the condition exhibits significant phenotypic variability. Such variability is influenced by the patients lifestyle, genetic predisposition and sex. In this
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Nomenclature for factors of the HLA system, update October, November and December 2023 Hum. Immunol. (IF 2.7) Pub Date : 2024-02-05 Steven G.E. Marsh
Abstract not available
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Monitored COVID-19 vaccine humoral response in immunocompromised solid organ transplant recipients Hum. Immunol. (IF 2.7) Pub Date : 2024-02-02 Afzal Nikaein, Ashley Chemmalakuzhy, Salman Khan, Judson Hunt, Derek Haumpy, Alok Choudhary, Abraham Pinter, Ayrton Sanchez, Mark Lerman
The SARS-CoV-2 pandemic has resulted in rapid research and vaccine development to help curtail unchecked transmission. However, these studies cannot be applied as easily among every population, such as immunocompromised individuals. In this study, we observed the humoral response of 70 total heart and renal transplant patients to mRNA SARS-CoV-2 vaccinations to help further understand the effectiveness
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Zika virus precursor membrane peptides induce immune response in peripheral blood mononuclear cells Hum. Immunol. (IF 2.7) Pub Date : 2024-01-25 Yogita Gupta, Manoj Baranwal, Bhupendra Chudasama
Zika virus is a re-merging flavivirus allied to serious mental health conditions in the fetuses. There is currently no preventives or treatment available for Zika infection. In this work, we have extended the analysis by performing the molecular docking of previous reported three conserved Zika virus precursor membrane (prM) peptides (MP1, MP2 and MP3) with HLA complex (pHLA) and T cell receptors (TCR)
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Activating KIR/HLA-I combinations as a risk factor of adult B-ALL Hum. Immunol. (IF 2.7) Pub Date : 2024-01-23 Hossein Halimi, Sara Mirzazadeh, Kurosh Kalantar, Maryam Hajimaghsoodi, Mani Ramzi, Shirin Farjadian
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Human Immunology thanks our 2023 reviewers Hum. Immunol. (IF 2.7) Pub Date : 2024-01-20
Abstract not available
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Dynamics of HLA and angiotensin II type 1 receptor antibodies during pregnancy Hum. Immunol. (IF 2.7) Pub Date : 2024-01-18 Carla Burballa, Laura Llinàs-Mallol, Susana Vázquez, M. José Pérez-Sáez, Carlos Arias-Cabrales, Anna Buxeda, José Luís Hernandez, Marta Riera, Sara Sanz, Elisenda Alari-Pahissa, Judith Federico-Vega, Jorge Eguía, Julio Pascual, Dolores Redondo-Pachón, Marta Crespo
Alloantibodies, especially anti-human leukocyte antigen antibodies (HLA antibodies), and autoantibodies, as angiotensin II type 1 receptor antibodies (AT1R antibodies), may complicate the access and the course of transplantation. Pregnancy is a known source of HLA antibodies, with most studies evaluating pregnancy-induced sensitization by complement-dependent cytotoxicity assays, mainly after childbirth
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Elevated levels of peripheral Th17 cells and Th17-related cytokines in patients with periampullary adenocarcinoma Hum. Immunol. (IF 2.7) Pub Date : 2024-01-04 Imteyaz Ahmad Khan, Nidhi Singh, Deepak Gunjan, Nihar Ranjan Dash, Baibaswata Nayak, Surabhi Gupta, Anoop Saraya
Aim Periampullary adenocarcinoma (PAC) is a malignant tumor originating at the ampulla of Vater, distal common bile duct, head of the pancreas, ampulla and duodenum. The levels of circulating Th17 cells and Th17-related cytokines in patients with PAC remain unreported. Therefore, the aim of this study was to determine the levels of circulating Th17 cells and Th17-related cytokines in patients with
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Expression of miR-21 & IL-4 in endometriosis Hum. Immunol. (IF 2.7) Pub Date : 2023-12-27 Reyhaneh Sadat Sandoghsaz, Fateme Montazeri, Hanieh Shafienia, Seyed Mehdi Kalantar, Atiyeh Javaheri, Morteza Samadi
Background Endometriosis characterized with existence of endometrial-like tissue outside the uterus. Fibrosis of ectopic lesions is an important feature of endometriosis. IL-4 induces fibrosis via fibroblast proliferation, collagen production and myofibroblast differentiation. Increasing of miR-21 expression promotes fibroblast activation and fibrosis expansion. The aim of study was to evaluate the
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Allergic manifestations in women with silicone breast implants Hum. Immunol. (IF 2.7) Pub Date : 2023-12-27 Galya Tanay, Gilad Halpert, Arad Dotan, Kassem Sharif, Avishai M. Tsur, Irit Shefler, Harald Heidecke, Howard Amital, Amir Tanay, Yoseph A. Mekori, Yehuda Shoenfeld
Introduction Silicone breast implants (SBI) result in immune dysregulation and are associated with autoimmune diseases. Recently, we reported dysregulated levels of IgG autoantibodies directed against G protein-coupled receptors (GPCRs) of the autonomic nervous system which were linked to the autoimmune dysautonomia in silicone breast implant illness (SBII). Aims We aimed to explore the possible association
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Differential expression of immune checkpoints (OX40/OX40L and PD-1/PD-L1) in decidua of unexplained recurrent spontaneous abortion women Hum. Immunol. (IF 2.7) Pub Date : 2023-12-22 Chenyue Qian, Chenhuan Pan, Juanjuan Liu, Lijuan Wu, Jie Pan, Cuiping Liu, Hong Zhang
In this study, we aimed to investigate the expression of OX40, OX40L, PD-1 and PD-L1 in patients with unexplained recurrent spontaneous abortion (URSA) compared to normal pregnancies (NP). A total of 50 patients who were diagnosed with URSA and 41 NP were recruited to this study. Real-time polymerase chain reaction (RT-PCR) was used to determine the expression of OX40, OX40L, PD-1 and PD-L1 in decidual
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Ankylosing spondylitis status and risk of secondary systemic amyloidosis: A two-sample mendelian randomization study Hum. Immunol. (IF 2.7) Pub Date : 2023-12-15 Hong Chen, Lingxiang Yu, Ming Shao
Objectives There is still controversy regarding the causal relationship between ankylosing spondylitis (AS) and secondary systemic amyloidosis (SSA). This study utilized aggregated data from genome-wide association studies (GWAS) on population cohorts to investigate whether a causal relationship exists between AS and SSA. Methods The genetic causal relationship between AS status and SSA was analyzed
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The elevation of plasma galectin-9 levels in patients with psoriasis and its associations with inflammatory and immune checkpoint molecules in skin tissues Hum. Immunol. (IF 2.7) Pub Date : 2023-12-12 Haorile Chagan-Yasutan, Nagongbilige He, Sarnai Arlud, Jun Fang, Toshio Hattori
Psoriasis is a chronic, immune-mediated disorder that mainly affects the skin, with an estimated global prevalence of 2–3%. Galectin-9 (Gal-9) is a β-galactoside-binding lectin capable of promoting or suppressing the progression of infectious and immune-mediated diseases. Here, we determined if the expression of Gal-9 is observed in psoriasis. Gal-9 levels were measured in plasma of psoriasis (n = 62)
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Altered regulatory T cell-mediated Natural Killer cells suppression may lead to generalized vitiligo Hum. Immunol. (IF 2.7) Pub Date : 2023-12-05 Prashant S. Giri, Soaeb S. Patel, Mitesh Dwivedi
Generalized vitiligo (GV) is characterized by white patches due to autoimmune loss of melanocytes. Regulatory T cells (Tregs) maintain immune homeostasis, while NK cells eliminate pathogens and tumors. Increased NK cell frequency and reduced Treg frequency and suppressive capacity are observed in vitiligo patients. However, studies assessing Treg-mediated suppression of NK cell functions in GV are
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The functional TNFAIP3 rs2230926T/G (Phe127Cys) variant confers risk to systemic lupus erythematosus in a Latin American population Hum. Immunol. (IF 2.7) Pub Date : 2023-12-01 Isela Montúfar-Robles, Rosa Elda Barbosa-Cobos, Juanita Romero-Díaz, Guillermo Valencia-Pacheco, Carlos Cabello-Gutiérrez, Julian Ramírez-Bello
TNFAIP3 is a classical systemic lupus erythematosus (SLE)-associated risk locus identified by genome-wide association studies (GWASs) and replicated by candidate gene association studies primarily in Caucasians and Asians. However, in Latin American populations, its role on SLE susceptibility is not known. We conducted a case-control study to evaluate whether the TNFAIP3 rs2230926T/G (Phe127Cys) variant
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The causal relationship between ankylosing spondylitis and the risk of ovarian cancer Hum. Immunol. (IF 2.7) Pub Date : 2023-11-30 Xiao Ma, Yongzheng Cui, Congcong Shi, Zhengxiang Han
Objective The aim of this study was to investigate the potential causal relationship between ankylosing spondylitis (AS) and ovarian cancer. Methods We conducted analyses utilizing publicly available pooled statistical data sets from genomewide association studies (GWAS) involving individuals of European ancestry. Our objective was to identify single nucleotide polymorphisms (SNPs) significantly associated
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Single-cell transcriptomics of peripheral blood mononuclear cells indicates impaired immune and inflammatory responses in alcohol-associated hepatitis Hum. Immunol. (IF 2.7) Pub Date : 2023-11-30 Xiaochen Liu, Zhang-Xu Liu, Timothy R. Morgan, Trina M. Norden-Krichmar
Alcohol-associated hepatitis (AH) is often diagnosed at advanced stages, and severe AH usually carries poor prognosis and high short-term mortality. In addition, it is challenging to understand the molecular mechanisms of immune dysregulation and inflammation in AH due to the cellular complexity and heterogeneity. Using single-cell RNA sequencing, previous studies found that AH causes dysfunctional
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Complement-dependent cytotoxicity crossmatch in solid organ transplantation: The gold standard or golden history? Hum. Immunol. (IF 2.7) Pub Date : 2023-11-29 Sandra Tafulo, Ermelinda Osório, Cecília Mendes, Robert Liwski
Complement-dependent cytotoxicity crossmatch (CDC-XM) has been considered for many years the standard of practice for determining compatibility in solid organ transplantation (SOT). However, as this method is laborious, time intensive and lacks sensitivity and specificity, it has been replaced in many laboratories worldwide by flow cytometry crossmatch (FCXM) and/or virtual crossmatch (vXM). With this
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Dr. James M. Mathew appointed Editor-in-Chief of Human Immunology Hum. Immunol. (IF 2.7) Pub Date : 2023-11-07
Abstract not available
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Function of gamma delta (γδ) T cell in cancer with special emphasis on cervical cancer Hum. Immunol. (IF 2.7) Pub Date : 2023-11-04 Soumendu Patra, Sayan Ghosal, Harshita Shand, Rittick Mondal, Ankita Rath, Saikat Kumar Jana, Suvankar Ghorai
Cervical cancer is the second-most prevalent gynecologic cancer in India. It is typically detected in women between the ages of 35 and 44. Cervical cancer is mainly associated with the human papillomavirus (HPV). The report shows that 70 % of cervical cancer is caused by HPV 16 and 18. There are few therapeutic options and vaccines available for cervical cancer treatment and γδ T cell therapy is one
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Nomenclature for factors of the HLA system, update July, August and September 2023 Hum. Immunol. (IF 2.7) Pub Date : 2023-11-03 Steven G.E. Marsh
Abstract not available
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Introducing article numbering to Human Immunology Hum. Immunol. (IF 2.7) Pub Date : 2023-10-27
Abstract not available
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Combined imputation of HLA genotype and self-identified race leads to better donor-recipient matching Hum. Immunol. (IF 2.7) Pub Date : 2023-10-21 Sapir Israeli, Loren Gragert, Abeer Madbouly, Pradeep Bashyal, Joel Schneider, Martin Maiers, Yoram Louzoun
Allogeneic Hematopoietic Cell Transplantation (HCT) is a curative therapy for hematologic disorders and often requires human leukocyte antigen (HLA)-matched donors. Donor registries have recruited donors utilizing evolving technologies of HLA genotyping methods. This necessitates in-silico ambiguity resolution and statistical imputation based on haplotype frequencies estimated from donor data stratified
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Kinetics of Torque Teno virus in heart transplant patients Hum. Immunol. (IF 2.7) Pub Date : 2023-10-20 Randi Berg, Tor S. Clemmensen, Mikkel S. Petersen, Lone J.H. Mogensen, Mette Christiansen, Katrine Rolid, Kari Nytrøen, Bjarne K. Møller, Lars Gullestad, Hans Eiskjær, Pernille Koefoed-Nielsen
End-stage heart failure often requires heart transplantation as a life-prolonging treatment. Immunosuppressive therapy is necessary to avoid rejection, but is associated with serious adverse effects. New approaches are needed to monitor immune function in heart transplant patients. We here report the kinetics of Torque Teno Virus (TTV) after transplantation in a large cohort of heart transplant patients
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CXCL1 promotes immune escape in colorectal cancer by autophagy-mediated MHC-I degradation Hum. Immunol. (IF 2.7) Pub Date : 2023-10-04 Jianqiao Kong, Song Xu, Peng Zhang, Yun Zhao
Background Immunotherapy is now seen as a potential remedy for colorectal cancer (CRC). Chemokines play a crucial role in tumors, including CRC, which contains CXCL1. We attempted to study how CXCL1 impacts immune escape in CRC. Methods Bioinformatics analysis was used to examine CXCL1 level in CRC. qRT-PCR was used to assess CXCL1 and MHC-I (HLA-A, B, C) levels. Cell Counting Kit-8 (CCK-8) was used
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DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study Hum. Immunol. (IF 2.7) Pub Date : 2023-10-04 Yujie Deng, Wei Xu, Man Ni, Xiaoya Sun, Xinqi Wang, Tao Zhang, Faming Pan
Objective The objectives of the present research were to ascertain the relationship of Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 6 (LGR6) methylation and transcript levels with ankylosing spondylitis (AS). Methods Targeted bisulfite sequencing was applied to analyze LGR6 DNA methylation in 81 AS cases and 81 controls. Besides, the LGR6 transcription level of peripheral blood mononuclear
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Coronavirus-19 disease risk and protective factors associated with HLA/KIR polymorphisms in Ecuadorian patients residing in Madrid Hum. Immunol. (IF 2.7) Pub Date : 2023-09-28 Antonio Balas, Miguel Ángel Moreno-Hidalgo, Fernando de la Calle-Prieto, José Luis Vicario, Marta Arsuaga, Elena Trigo, Rosa de Miguel-Buckley, Teresa Bellón, Marta Díaz-Menéndez
Background Immigrants represented 21.8% of cases in a Spanish cohort of hospitalised patients with COVID-19, a proportion exceeding the percentage of immigrants in that area’s total population. Among the ethnic-related genetic risk factors for COVID-19, human leukocyte antigen (HLA) genotypes in diverse populations might bias the response to SARS-CoV-2 infection and/or progression. Similarly, genetic
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In silico analysis of missense SNPs in TNFR1a and their possible therapeutic or pathogenic role in immune diseases Hum. Immunol. (IF 2.7) Pub Date : 2023-09-23 Maria Arshad, Nabeel Noor, Zunair Iqbal, Hadiqa Jaleel
Tumor necrosis factor alpha (TNFa) is an inflammatory cytokine that is involved in the pathogenesis of various inflammatory disorders including rheumatoid arthritis. TNF-alpha receptor I (TNFR1a) is one of the receptors TNFa binds with for its activation. Any variation in this receptor might affect the role of TNFa in successive events. Amino acid residue substitutions might happen in TNFR1a through
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USP8 targeted by Mir-874-3p promotes trophoblastic cell invasion by stabilizing the expression of ENaC on trophoblast membrane Hum. Immunol. (IF 2.7) Pub Date : 2023-09-21 Suqin Zhang, Yanmei Shi, Pingping Dong
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A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps Hum. Immunol. (IF 2.7) Pub Date : 2023-09-09 Gabriele Foos, Nina Blazeska, Morten Nielsen, Hannah Carter, Zeynep Kosaloglu-Yalcin, Bjoern Peters, Alessandro Sette
Background The Cancer Epitope Database and Analysis Resource (CEDAR) is a newly developed repository of cancer epitope data from peer-reviewed publications, which includes epitope-specific T cell, antibody, and MHC ligand assays. Here we focus on prostate cancer as our first cancer category to demonstrate the capabilities of CEDAR, and to shed light on the advances of epitope-related prostate cancer
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Persistent sepsis-induced transcriptomic signatures in signaling pathways of peripheral blood leukocytes: A pilot study Hum. Immunol. (IF 2.7) Pub Date : 2023-09-04 Zsuzsanna Elek, Eszter Losoncz, Zoltán Fülep, Réka Kovács-Nagy, Zsófia Bánlaki, Gergely Szlobodnyik, Gergely Keszler, Zsolt Rónai
Sepsis is a dysregulated immune response to infections that frequently precipitates multiple organ dysfunction and death despite intensive supportive therapy. The aim of the present study was to identify sepsis-induced alterations in the signaling transcriptome of peripheral blood leukocytes that might shed light on the elusive transition from proinflammatory to anti-inflammatory responses and underlie
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Decoding the contextual duality of CD40 functions Hum. Immunol. (IF 2.7) Pub Date : 2023-08-16 Syamdas Bandyopadhyay, Dhiraj Gurjar, Bhaskar Saha, Neelam Bodhale
Previously, we established that as a function of its mode of interaction with its ligand or cellular conditions such as membrane lipids, preexisting signaling intermediates activation status, a transmembrane receptor, as represented here with CD40, can induce counteractive cellular responses. Using CD40-binding peptides, recombinant mutated CD40-ligands, and an agonistic antibody, we have established
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Diminished Interleukin-7 receptor expression on T-cell subsets in tuberculosis patients Hum. Immunol. (IF 2.7) Pub Date : 2023-08-12 Isaac Acheampong, Difery Minadzi, Ernest Adankwah, Wilfred Aniagyei, Monika M. Vivekanandan, Augustine Yeboah, Joseph F. Arthur, Millicent Lamptey, Mohammed K. Abass, Francis Kumbel, Francis Osei-Yeboah, Amidu Gawusu, Edwin F. Laing, Linda Batsa Debrah, Dorcas O. Owusu, Alexander Debrah, Ertan Mayatepek, Julia Seyfarth, Richard O. Phillips, Marc Jacobsen
Immunopathology in human tuberculosis affects T-cell phenotype and functions. Previous studies identified impaired T-cell sensitivity to Interleukin (IL)-7 accompanied by lower IL-7 receptor α-chain (IL-7Rα) expression in patients with acute tuberculosis. In the present study, we characterized affected T-cell subsets and determined the influence of tuberculosis disease severity and treatment response
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Th1 or Th2 cytokines are correlated with Tregs and T cell subsets and pregnancy outcomes in patients with autoimmune thyroid disease during early, middle, late pregnancy, and postpartum period Hum. Immunol. (IF 2.7) Pub Date : 2023-08-09 Mei Zhong, Hui Chen, Jiao Lan, Chunyong Lan, Lan Liang, Jingming Yu, Hua Zhong, Xing Zhou, Jie Lu, Xiaoyan Tan, Wensheng Lu
Autoimmune thyroid disease (AITD) is a T lymphocytes-mediated autoimmune disorder affecting pregnant women. The current study sought to determine the correlations between T helper-1 (Th1)/T helper-2 (Th2) cytokines and regulatory T cells (Tregs) and T cell subsets and pregnancy outcomes in AITD patients during early pregnancy (T1), middle pregnancy (T2), late pregnancy (T3), and postpartum period (PP)
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ASHI announces incoming Editor-in-Chief for Human Immunology Hum. Immunol. (IF 2.7) Pub Date : 2023-08-08
Abstract not available
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Study of association between antibodies to non-HLA kidney self-antigens and progression to chronic immune injury after kidney transplantation Hum. Immunol. (IF 2.7) Pub Date : 2023-07-26 Sumi Nair, Ranjithkumar Ravichandran, Raymond Heilman, Andrés Jaramillo, Matthew Buras, Bruce Kaplan, Yoshihiro Itabashi, Daniel Ramon, Katrin Hacke, Byron Smith, Thalachallour Mohanakumar
Background Immune response to several kidney self-antigens (KSAg) such as Collagen IV (Col-IV), Perlecan (PL), and Fibronectin (FN) have been associated with antibody-mediated damage and poor allograft survival. Thus, the aim of this study was to determine if humoral immune responses to KSAg correlates with progression of chronic immune injury (CII) changes at 1 year or 2 years. Methods Kidney transplant
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Nomenclature for factors of the HLA system, update April, May and June 2023 Hum. Immunol. (IF 2.7) Pub Date : 2023-07-21 Steven G.E. Marsh
Abstract not available
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Lower PTEN may be associated with CD8+ T cell exhaustion in diffuse large B-cell lymphoma Hum. Immunol. (IF 2.7) Pub Date : 2023-07-21 Shutao Zheng, Jiajia Ma, Junna Li, Xuelian Pang, Mingfu Ma, Zhiping Ma, Wenli Cui
Initially discovered in chronic viral infection and then extended to tumor, 'T-cell exhaustion' is a broad term describing the response of T cells to chronic antigen stimulation. By definition, whether T-cell exhaustion occurs in diffuse large B-cell lymphoma (DLBCL) remains largely unknown because little has been described. Here, the immune-suppressing checkpoint molecules involved in T-cell exhaustion
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Influence of interleukin-8 polymorphism on endometriosis-related pelvic pain Hum. Immunol. (IF 2.7) Pub Date : 2023-07-18 Jéssica Vilarinho Cardoso, Daniel Escorsim Machado, Mayara Calixto da Silva, Matheus Pereira de Mello, Plinio Tostes Berardo, Rui Medeiros, Jamila Alessandra Perini
Endometriosis presents a pro-inflammatory microenvironment influenced by cytokines, such as interleukin (IL)-8, which expression may be influenced by genetic polymorphisms. Therefore, we aimed to investigate the role of interleukin (IL)-8 rs4073 polymorphism in endometriosis’ development and its related symptoms. A case-control study was conducted with 207 women with endometriosis and 193 healthy controls
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Detailed characterization of PD-1/PD-L1 and CTLA4 expression and tumor-infiltrating lymphocytes in yolk sac tumors Hum. Immunol. (IF 2.7) Pub Date : 2023-07-13 Danya Zhang, Hanjie Xu, Can Zhao, Lingzhi Qin, Rui Wei, Ling Xi, Fei Li
Background Immune checkpoint blockade (ICB) is considered as a promising approach for cancer treatment. However, the potency of ICB therapy in yolk sac tumors (YSTs) has not been confirmed, and the comprehensive analysis of tumor immune microenvironment and the expression of PD-1/PD-L1 and CTLA4 were also not thoroughly evaluated. Methods Immunohistochemistry was performed in formalin-fixed, paraffin-embedded
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Identification of B-cell-related HSPG2 and CDSN as susceptibility loci for Kawasaki disease Hum. Immunol. (IF 2.7) Pub Date : 2023-07-13 Jae-Jung Kim, Young Mi Hong, Sin Weon Yun, Kyung-Yil Lee, Kyung Lim Yoon, Myung-Ki Han, Gi Beom Kim, Hong-Ryang Kil, Min Seob Song, Hyoung Doo Lee, Kee Soo Ha, Hyun Ok Jun, Jeong Jin Yu, Gi Young Jang, Jong-Keuk Lee
Kawasaki disease (KD) is an acute pediatric vasculitis that predominantly affects children under the age of 5 years. To date, genome-wide association studies (GWAS) have identified several KD susceptibility genes (e.g., BLK, CD40, FCGR2A, BCL2L11, and IGHV), which are mainly involved in B cell immunity. In this study, we aimed to identify additional KD susceptibility genes mainly involved in B cell
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The β2-adrenergic receptor agonist terbutaline upregulates T helper-17 cells in a protein kinase A-dependent manner Hum. Immunol. (IF 2.7) Pub Date : 2023-07-10 Catalina M. Carvajal Gonczi, Mehri Hajiaghayi, Fatemeh Gholizadeh, Maria Auxiliadora Xavier Soares, Fadi Touma, Carolina Lopez Naranjo, Amanda J. Rios, Chelsea Pozzebon, Tina Daigneault, Kelly Burchell-Reyes, Peter J. Darlington
Background T helper 17 (Th17) cells produce IL-17A cytokine and can exacerbate autoimmune diseases and asthma. The β2 adrenergic receptor is a g protein-coupled receptor that induces cAMP second messenger pathways. We tested the hypothesis that terbutaline, a β2-adrenergic receptor-specific agonist, promotes IL-17 secretion by memory Th17 cells in a cAMP and PKA-dependent manner. Methods Venous peripheral
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Thymic stromal lymphopoietin participates in the host response to intra-amniotic inflammation leading to preterm labor and birth Hum. Immunol. (IF 2.7) Pub Date : 2023-07-06 Tomi Kanninen, Li Tao, Roberto Romero, Yi Xu, Marcia Arenas-Hernandez, Jose Galaz, Zhenjie Liu, Derek Miller, Dustyn Levenson, Jonathan M. Greenberg, Jonathan Panzer, Justin Padron, Kevin R. Theis, Nardhy Gomez-Lopez
The aim of this study was to establish the role of thymic stromal lymphopoietin (TSLP) in the intra-amniotic host response of women with spontaneous preterm labor (sPTL) and birth. Amniotic fluid and chorioamniotic membranes (CAM) were collected from women with sPTL who delivered at term (n = 30) or preterm without intra-amniotic inflammation (n = 34), with sterile intra-amniotic inflammation (SIAI
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Epitopes, paratopes, and other topes 30 years on: Understanding what we are talking about Hum. Immunol. (IF 2.7) Pub Date : 2023-07-06 Neil S. Greenspan
The question of which protein antigens, such as HLA class I or class II molecules, will bind, and how well, to a given antibody is often assumed to depend exclusively on the details of protein surface structure. These structures are usually based on static models resulting from X-ray crystallography. While these notions are useful, the ultimate causal factors determining how well a given antigen binds
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Interferon lambda modulates proinflammatory cytokines production in PBMCs from patients with chronic kidney disease Hum. Immunol. (IF 2.7) Pub Date : 2023-06-30 Yuhao Xia, Qiannan Yang, Shang Ying Wu, Zhicheng Wu, Qian Li, Jing Du
Background CKD is a major cause of morbidity and mortality worldwide. Considerable evidence now indicates that renal inflammation plays a central role in the initiation and progression of CKD. Recent investigations have demonstrated that IFNλ plays an important role in the pathogenesis of autoimmune and inflammatory diseases. However, the association of IFNλ with CKD is still poorly understood. Objective
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Differential NRAMP1gene’s D543N genotype frequency: Increased risk of contracting tuberculosis among Venezuelan populations Hum. Immunol. (IF 2.7) Pub Date : 2023-06-26 Zaida Araujo, Milena Camargo, Darwin A. Moreno Pérez, Albina Wide, Dailobivxon Pacheco, Diana Díaz Arévalo, Carmen T. Celis Giraldo, Sandra Salas, Jacobus H. de Waard, Manuel A. Patarroyo
NRAMP1 and VDR gene polymorphisms have been variably associated with susceptibility to tuberculosis (TB) amongst populations having different genetic background. NRAMP1 and VDR gene variants’ association with susceptibility to active infection by Mycobacterium tuberculosis (Mtb) was analyzed in the Warao Amerindian population, an ethnic population from Venezuela’s Orinoco delta region. Genomic DNA
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Special Issue: 9th International Conference on HLA-G Hum. Immunol. (IF 2.7) Pub Date : 2023-06-24 Edgardo D. Carosella
Abstract not available
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Role of inflammation and immune response in atherosclerosis: Mechanisms, modulations, and therapeutic targets Hum. Immunol. (IF 2.7) Pub Date : 2023-06-21 Fang Liu, Yijun Wang, Jiayin Yu
Cardiovascular diseases (CVDs) have emerged as the leading cause of mortality globally, with atherosclerosis being a prominent focus of investigation among medical researchers worldwide. Atherosclerosis is characterized as a disease of the large and medium-sized arteries that is multifocal, accumulative, and immunoinflammatory in nature, resulting from the deposition of lipids. Accumulating evidence
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Combining nano-curcumin with catechin improves COVID-19-infected patient's inflammatory conditions Hum. Immunol. (IF 2.7) Pub Date : 2023-06-05 Talar Ahmad Merza Mohammad
Aims A hyperinflammatory condition is brought on by the development of Coronavirus disease 2019 (COVID-19), which is characterized by an elevation of T helper (Th) 17 cells, high levels of pro-inflammatory cytokines, and a depletion of regulatory T (Treg) cells. Methods In this research, we examined the effect of nano-curcumin and catechin on the TCD4+, TCD8+, Th17, and Treg cells and their associated