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Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis J. Inflamm. (IF 5.1) Pub Date : 2024-03-20 Qixin Wang, Chiara Goracci, Isaac Kirubakaran Sundar, Irfan Rahman
Environmental tobacco smoke (ETS) is known to cause lung inflammatory and injurious responses. Smoke exposure is associated with the pathobiology related to lung fibrosis, whereas the mechanism that ETS exposure augments pulmonary fibrogenesis is unclear. We hypothesized that ETS exposure could exacerbate fibrotic responses via collagen dynamic dysregulation and complement activation. C57BL/6J and
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Retraction Note: VEGF as a potential molecular target in periodontitis: a meta-analysis and microarray data validation J. Inflamm. (IF 5.1) Pub Date : 2024-03-15 Bo Ren, Que Feng, Shan He, Yanfeng Li, Jiadong Fan, Guangquan Chai, Le Liu , Haiyun Liu, Chunhao Yang, Yingdi Wang, Huihui Liu, Huanyue Liu, Yafan Song
Retraction Note: Journal of Inflammation (2021) 18:18 https://doi.org/10.1186/s12950-021-00281-9 The Editors-in-Chief have retracted this article after concerns were raised about the data reported. The two datasets used in this analysis, GSE10334 and GSE16134, were each generated from the same archive of healthy and diseased gingival tissues, and as such there is a significant sampling overlap between
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Pediatric sepsis inflammatory blood biomarkers that correlate with clinical variables and severity of illness scores J. Inflamm. (IF 5.1) Pub Date : 2024-03-07 Sean Leonard, Hailey Guertin, Natalya Odoardi, Michael R. Miller, Maitray A. Patel, Mark Daley, Gediminas Cepinskas, Douglas D. Fraser
Sepsis is a dysregulated systemic inflammatory response triggered by infection, resulting in organ dysfunction. A major challenge in clinical pediatrics is to identify sepsis early and then quickly intervene to reduce morbidity and mortality. As blood biomarkers hold promise as early sepsis diagnostic tools, we aimed to measure a large number of blood inflammatory biomarkers from pediatric sepsis patients
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Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications J. Inflamm. (IF 5.1) Pub Date : 2024-02-28 Xue Lin, Ye Wang, Yanqi He
Mucosal-associated invariant T (MAIT) cells are an atypical subset of T lymphocytes, which have a highly conserved semi-constant αβ chain of T-cell receptor (TCR) and recognize microbe-derived vitamin B metabolites via major histocompatibility complex class I related-1 molecule (MR1). MAIT cells get activated mainly through unique TCR-dependent and TCR-independent pathways, and express multiple functional
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The preventive effects of Lactobacillus casei 03 on Escherichia coli-induced mastitis in vitro and in vivo J. Inflamm. (IF 5.1) Pub Date : 2024-02-23 Ke Li, Ming Yang, Mengyue Tian, Li Jia, Yinghao Wu, Jinliang Du, Lining Yuan, Lianmin Li, Yuzhong Ma
Lactobacillus casei possesses many kinds of bioactivities, such as anti-inflammation and anti-oxidant, and has been applied to treating multiple inflammatory diseases. However, its role in mastitis prevention has remained ambiguous. This study aimed to examine the mechanisms underlying the preventive effects of L. casei 03 against E. coli- mastitis utilizing bovine mammary epithelial cells (BMECs)
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Tissue-plasminogen activator effects on the phenotype of splenic myeloid cells in acute inflammation J. Inflamm. (IF 5.1) Pub Date : 2024-02-14 Célia Seillier, Léonie Lesec, Pauline Hélie, Charlotte Marie, Denis Vivien, Fabian Docagne, Brigitte Le Mauff, Olivier Toutirais
Tissue-plasminogen activator (tPA) is a serine protease well known for its fibrinolytic function. Recent studies indicate that tPA could also modulate inflammation via plasmin generation and/or by receptor mediated signalling in vitro. However, the contribution of tPA in inflammatory processes in vivo has not been fully addressed. Therefore, using tPA-deficient mice, we have analysed the effect of
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Role of meningeal immunity in brain function and protection against pathogens J. Inflamm. (IF 5.1) Pub Date : 2024-01-30 Julie Rebejac, Elisa Eme-Scolan, Rejane Rua
The brain and spinal cord collectively referred to as the Central Nervous System (CNS) are protected by the blood-brain barrier that limits molecular, microbial and immunological trafficking. However, in the last decade, many studies have emphasized the protective role of ‘border regions’ at the surface of the CNS which are highly immunologically active, in contrast with the CNS parenchyma. In the
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Anti-hyperalgesic and anti-inflammatory effects of 4R-tobacco cembranoid in a mouse model of inflammatory pain J. Inflamm. (IF 5.1) Pub Date : 2024-01-24 Luis G. Rivera-García, Adela M. Francis-Malavé, Zachary W. Castillo, Calvin D. Uong, Torri D. Wilson, P. A. Ferchmin, Vesna Eterovic, Michael D. Burton, Yarimar Carrasquillo
4R is a tobacco cembranoid that binds to and modulates cholinergic receptors and exhibits neuroprotective and anti-inflammatory activity. Given the established function of the cholinergic system in pain and inflammation, we propose that 4R is also analgesic. Here, we tested the hypothesis that systemic 4R treatment decreases pain-related behaviors and peripheral inflammation via modulation of the alpha
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Interleukin-6-elicited chronic neuroinflammation may decrease survival but is not sufficient to drive disease progression in a mouse model of Leigh syndrome J. Inflamm. (IF 5.1) Pub Date : 2024-01-11 Kevin Aguilar, Carla Canal, Gemma Comes, Sandra Díaz-Clavero, Maria Angeles Llanos, Albert Quintana, Elisenda Sanz, Juan Hidalgo
Mitochondrial diseases (MDs) are genetic disorders characterized by dysfunctions in mitochondria. Clinical data suggest that additional factors, beyond genetics, contribute to the onset and progression of this group of diseases, but these influencing factors remain largely unknown. Mounting evidence indicates that immune dysregulation or distress could play a role. Clinical observations have described
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SARS-CoV-2 spike protein accelerates systemic sclerosis by increasing inflammatory cytokines, Th17 cells, and fibrosis J. Inflamm. (IF 5.1) Pub Date : 2023-12-21 Ha Yeon Jeong, Jin-Sil Park, Jin Seok Woo, Kun Hee Lee, Jeong Won Choi, Hye Yeon Kang, Hyun Sik Na, Yeon Su Lee, In Gyu Um, Sung-Hwan Park, Mi-La Cho
Coronavirus disease 2019 (COVID-19) induces a dysfunctional immune response, inflammation, autoantibody production, and coagulopathy, which are symptoms that bear resemblance to those of autoimmune diseases, including systemic sclerosis (SSc). While there is a single case report suggesting an association between COVID-19 and SSc, the effects of COVID-19 on SSc are not yet fully understood. Human embryonic
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Retraction Note: Valproic acid attenuates intercellular adhesion molecule-1 and E-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model J. Inflamm. (IF 5.1) Pub Date : 2023-12-20 Chih-Zen Chang, Shu-Chuan Wu, Chih-Lung Lin, Aij-Lie Kwan
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12950-015-0074-3.
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Lonicera japonica Thunb extract ameliorates lipopolysaccharide-induced acute lung injury associated with luteolin-mediated suppression of NF-κB signaling pathway J. Inflamm. (IF 5.1) Pub Date : 2023-12-19 Qinyao Jia, Jing wen, Qi Yang, Shengming Liu, Jianwu Zhang, Tao Wang, Yao Cheng
Lonicera japonica Thunb (LJT) is a commonly used herbal soup to treat inflammation-related diseases. However, the effect of LJT on ALI is unknown. The present study was aimed at investigating the protective effects of LJT extract (LTE) and its active ingredient luteolin (Lut) on lipopolysaccharide (LPS)-stimulated ALI and investigate its potential mechanism. The effects of LTE and Lut were explored
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Circadian dependency of microglial heme oxygenase-1 expression and inflammation determine neuronal injury in hemorrhagic stroke J. Inflamm. (IF 5.1) Pub Date : 2023-12-16 Luise Henrich, Iva Kiessling, Matti Steimer, Sibylle Frase, Sandra Kaiser, Nils Schallner
The heme oxygenase-1 (HO-1) enzyme pathway is of crucial importance in the removal of toxic blood components and regulation of neuroinflammation following hemorrhagic stroke. Although a circadian pattern dependency in the incidence and severity of hemorrhagic stroke exists, it is unknown whether the activity of the HO-1 system in the context of hemorrhagic injury also exhibits circadian dependency
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Retraction Note: Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats J. Inflamm. (IF 5.1) Pub Date : 2023-11-29 Qing Yuan, Yan-wen Jiang, Ting-ting Ma, Qiu-hong Fang, Lei Pan
The Editors-in-Chief have retracted this article. After publication, concerns were raising regarding extensive overlap between the data presented in this article and another article from the same authors that was under consideration within a similar time frame [1]. The authors have stated that the data were misused in the other article [1] by mistake and provided the raw data for validation. However
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Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases J. Inflamm. (IF 5.1) Pub Date : 2023-11-24 Huakang Zhou, Dilaware Khan, Sajid Muhammad Hussain, Norbert Gerdes, Carsten Hagenbeck, Majeed Rana, Jan Frederick Cornelius, Sajjad Muhammad
Smoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. These risk factors generate oxidative stress and cause oxidative stress-induced DNA damage, resulting in cellular senescence and senescence-associated secretory phenotype (SASP). The SASP factors in feed-forward response exacerbate inflammation and cause tissue remodeling, resulting in atherosclerotic
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SARS-CoV-2 infection as a model to study the effect of cinnamaldehyde as adjuvant therapy for viral pneumonia J. Inflamm. (IF 5.1) Pub Date : 2023-11-20 Bianca Vezzani, Mariasole Perrone, Marianna Carinci, Laura Palumbo, Alberto Tombolato, Denis Tombolato, Claudio Daminato, Valentina Gentili, Roberta Rizzo, Gianluca Campo, Luca Morandi, Alberto Papi, Savino Spadaro, Paolo Casolari, Marco Contoli, Paolo Pinton, Carlotta Giorgi
The recent pandemic outbursts, due to SARS-CoV-2, have highlighted once more the central role of the inflammatory process in the propagation of viral infection. The main consequence of COVID-19 is the induction of a diffuse pro-inflammatory state, also defined as a cytokine storm, which affects different organs, but mostly the lungs. We aimed to prove the efficacy of cinnamaldehyde, the active compound
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Lipid from electronic cigarette-aerosol both with and without nicotine induced pro-inflammatory macrophage polarization and disrupted phagocytosis J. Inflamm. (IF 5.1) Pub Date : 2023-11-17 Mizanur Rahman, Shanzina Iasmin Sompa, Micol Introna, Swapna Upadhyay, Koustav Ganguly, Lena Palmberg
Clinical cases and experimental evidence revealed that electronic cigarettes (ECIG) induce serious adverse health effects, but underlying mechanisms remain to be fully uncovered. Based on recent exploratory evidence, investigating the effects of ECIG on macrophages can broadly define potential mechanisms by focusing on the effect of ECIG exposure with or without nicotine. Here we investigated the effect
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Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation J. Inflamm. (IF 5.1) Pub Date : 2023-11-10 Kristian Barry, Christopher Harpur, Maggie Lam, Michelle D. Tate, Ashley Mansell
Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inflammatory disease of the lung and nervous system. Our current understanding as to how Hendra virus or what factors induce inflammation is limited and as such, there are currently no therapeutic options available for patients who contract Hendra virus. Recent studies have identified
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Sodium butyrate alleviates R97-116 peptide-induced myasthenia gravis in mice by improving the gut microbiota and modulating immune response J. Inflamm. (IF 5.1) Pub Date : 2023-11-03 Jing Sun, Juanjuan Chen, Qinfang Xie, Mengjiao Sun, Wenjing Zhang, Hongxia Wang, Ning Liu, Qi Wang, Manxia Wang
Fermented butyrate exhibits an anti-inflammatory response to maintain immune homeostasis within the gut. However, the effect and underlying mechanism of butyrate on myasthenia gravis (MG) remain unclear. The changes in the gut microbiota and fecal contents of SCFAs in MG patients were examined. R97-116 peptide was used to induce the experimental autoimmune myasthenia gravis (EAMG) mice and sodium butyrate
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Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway J. Inflamm. (IF 5.1) Pub Date : 2023-11-01 Yue Yu, Ailin Yang, Xin He, Bo Wu, Yanjun Wu, Yunxiao Li, Shan Nie, Bo Xu, Haoyan Wang, Ganggang Yu
Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway inflammation in chronic obstructive pulmonary disease (COPD). Considering the excessive endoplasmic reticulum stress is associated with the earlier onset of COPD. The role of sEH and endoplasmic reticulum stress in the pathogenesis of COPD remains unknown. 16 weeks of cigarette-exposed
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The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice J. Inflamm. (IF 5.1) Pub Date : 2023-11-01 Mengqi Guo, Zongyi Xia, Yefeng Hong, Hongwei Ji, Fuhai Li, Wenheng Liu, Shaohua Li, Hui Xin, Kai Tan, Zhexun Lian
Diabetes mellitus is one of the causes of poor ventricular remodelling and poor cardiac recovery after myocardial infarction (MI). We previously reported that tissue factor pathway inhibitor-2 (TFPI2) was downregulated in response to hyperglycaemia and that it played a pivotal role in extracellular matrix (ECM) degradation and cell migration. Nonetheless, the function and mechanism of TFPI2 in post-MI
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IgG immune complex-induced acute lung injury is ameliorated by cAMP via down-regulation of C/EBP- and AP-1-mediated transcriptions J. Inflamm. (IF 5.1) Pub Date : 2023-10-20 Chunguang Yan, Jing Chen, Huifang Tang, Chunmin Deng, Qi Zhang, Ximo Wang
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) are life threatening pulmonary diseases, and we are now lack of effective therapeutic methods. Inflammatory responses are essential for initiating ALI/ARDS. Thus, ameliorating inflammatory reaction might be beneficial for treatment of the disease. There are increasing data that phosphodiesterase-4 (PDE4)-selective
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Advances in the study of macrophage polarization in inflammatory immune skin diseases J. Inflamm. (IF 5.1) Pub Date : 2023-10-12 Tingting Xia, Shengping Fu, Ruilin Yang, Kang Yang, Wei Lei, Ying Yang, Qian Zhang, Yujie Zhao, Jiang Yu, Limei Yu, Tao Zhang
When exposed to various microenvironmental stimuli, macrophages are highly plastic and primarily polarized into the pro-inflammatory M1-type and the anti-inflammatory M2-type, both of which perform almost entirely opposing functions. Due to this characteristic, macrophages perform different functions at different stages of immunity and inflammation. Inflammatory immune skin diseases usually show an
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Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates J. Inflamm. (IF 5.1) Pub Date : 2023-10-09 Erik Fung, Eunice Y. S. Chan, Kwan Hung Ng, Ka Man Yu, Huijun Li, Yulan Wang
Cardiometabolic diseases are associated with low-grade inflammation early in life and persists into old age. The long latency period presents opportunities for early detection, lifestyle modification and intervention. However, the performance of conventional biomarker assays to detect low-grade inflammation has been variable, particularly for early-stage cardiometabolic disorder including prediabetes
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Genome-wide identification and functional analysis of dysregulated alternative splicing profiles in sepsis J. Inflamm. (IF 5.1) Pub Date : 2023-09-25 Dilixiati Tuerdimaimaiti, Buzukela Abuduaini, Shaotao Kang, Jinliang Jiao, Mengchen Li, Wolazihan Madeniyati, Baihetinisha Tuerdi, Gulisitan Aili, Reyila Tuerhong, Ajiguli Kulaxi
An increasing body of evidence now shows that the long-term mortality of patients with sepsis are associated with various sepsis-related immune cell defects. Alternative splicing (AS), as a sepsis-related immune cell defect, is considered as a potential immunomodulatory therapy target to improve patient outcomes. However, our understanding of the role AS plays in sepsis is currently insufficient. This
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Inhibition of COX-2 signaling favors E. coli during urinary tract infection J. Inflamm. (IF 5.1) Pub Date : 2023-09-11 Soumitra Mohanty, Ciska Lindelauf, John Kerr White, Andrea Scheffschick, Ewa Ehrenborg, Isak Demirel, Hanna Brauner, Annelie Brauner
To avoid the overuse of antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), acting via cyclooxygenase (COX) inhibition, have been used to reduce pain and as an alternative treatment for uncomplicated urinary tract infections (UTIs). However, clinical studies evaluating NSAIDs versus antibiotics have reported an increased risk of acute pyelonephritis. Therefore, we hypothesized that COX inhibition
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Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress J. Inflamm. (IF 5.1) Pub Date : 2023-08-30 Yinzhou Zhang, Junying Wei, Xinyuan Wu, Mengting Jiang, Wuhua Ma, Yuhui Li
The strong perioperative stress response caused by surgical anesthesia can significantly suppress immune function, and the body is in a state of immunosuppression for 3 to 4 days after surgery, which leads to an increase in the probability of postoperative infection. Traditional Chinese medicine believes that acupuncture points can "reconcile yin and yang", promote the recovery of immune function,
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Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis J. Inflamm. (IF 5.1) Pub Date : 2023-08-21 Ziwen Zhao, Zhao Xu, Jingwen Chang, Liwei He, Zijin Zhang, Xiaoyu Song, Xianbang Hou, Fangtian Fan, Zhijun Jiang
Ferroptosis in alveolar and bronchial epithelial cells is one of the main mechanisms underlying the development of chronic obstructive pulmonary disease (COPD). Sodium pyruvate (NaPyr) is a natural antioxidant in the body, exhibiting anti-inflammatory and antioxidant activities. NaPyr has been used in a Phase II clinical trial as a novel therapy for COPD; however, the mechanism underlying NaPyr-mediated
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Correction: Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS J. Inflamm. (IF 5.1) Pub Date : 2023-08-16 Jennifer A. Cartwright, Joanna P. Simpson, Natalie Z. M. Homer, Adriano G. Rossi
Journal of Inflammation (2023) 20:20 https://doi.org/10.1186/s12950-023-00345-y After publication of this article [1], the authors reported that (1) in the ‘Availability of data and materials’-section, the link to the data (MS data (https://doi.org/10.7488/ds/7453)) is missing; (2) in Fig. 5, 3rd panel (Linear Regression AT7519 + ALT), the ALT units should be U/L and not µ/l. The original article [1]
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Air pollution induces pyroptosis of human monocytes through activation of inflammasomes and Caspase-3-dependent pathways J. Inflamm. (IF 5.1) Pub Date : 2023-08-10 Adrianna Gałuszka-Bulaga, Karolina Tkacz, Kazimierz Węglarczyk, Maciej Siedlar, Jarek Baran
According to the World Health Organization (WHO), air pollution is one of the most serious threats for our planet. Despite a growing public awareness of the harmful effects of air pollution on human health, the specific influence of particulate matter (PM) on human immune cells remains poorly understood. In this study, we investigated the effect of PM on peripheral blood monocytes in vitro. Monocytes
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Finding the priority and cluster of inflammatory biomarkers for infectious preterm birth: a systematic review J. Inflamm. (IF 5.1) Pub Date : 2023-07-24 Jiayi Li, Jianrong Ge, Na Ran, Changwu Zheng, Yumeng Fang, Danna Fang, Qian Yang, Yeling Ma
Infectious preterm birth (PTB) is one of the most important causes of perinatal death. It is difficult to find reliable biomarkers accurate to gestational weeks for infectious PTB prediction clinically. Infectious PTB is found usually accompanied with immune imbalance. Thus, the systematic study to find the priority of inflammatory biomarkers and innovative inflammatory clusters for infectious PTB
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Inhibition of GSK3β activity alleviates acute liver failure via suppressing multiple programmed cell death J. Inflamm. (IF 5.1) Pub Date : 2023-07-13 Danmei Zhang, Chunxia Shi, Qingqi Zhang, Yukun Wang, Jin Guo, Zuojiong Gong
Acute liver failure (ALF) is one of the most common life-threatening diseases in adults without previous liver disease. Glycogen synthase kinase 3β (GSK3β) is a serine/threonine protein kinase that is widely distributed in the cells. Inhibition of its activity can inhibit cell death and promote autophagy through various pathways, thus providing a protective effect. In this study, we aimed to investigate
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The occurrence and development of radiation-induced lung injury after interstitial brachytherapy and stereotactic radiotherapy in SD rats J. Inflamm. (IF 5.1) Pub Date : 2023-07-10 Zhuo Chen, Bin Wang, Zhouxue Wu, Hua Xiao, Yang Yang, Junying Fan, Yingjiang Gu, Chuan Chen, Jingbo Wu
To compare the severity of radiation-induced lung injury (RILI) after the right lung of SD rats received interstitial brachytherapy and stereotactic radiotherapy (SBRT). RILI rat model was established using interstitial brachytherapy and SBRT methods, respectively. CT scan was performed to analyze the lung volume and the CT value difference between the left and right lungs in rats. Then the lung tissues
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Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation J. Inflamm. (IF 5.1) Pub Date : 2023-06-27 Caroline Lindblad, Susanne Neumann, Sólrún Kolbeinsdóttir, Vasilios Zachariadis, Eric P. Thelin, Martin Enge, Sebastian Thams, Lou Brundin, Mikael Svensson
Astrocytes respond to injury and disease through a process known as reactive astrogliosis, of which inflammatory signaling is one subset. This inflammatory response is heterogeneous with respect to the inductive stimuli and the afflicted central nervous system region. This is of plausible importance in e.g. traumatic axonal injury (TAI), where lesions in the brainstem carries a particularly poor prognosis
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Ischemic stroke-related gene expression profiles across species: a meta-analysis J. Inflamm. (IF 5.1) Pub Date : 2023-06-19 Ruslan Rust
Stroke patients are often left with permanent disabilities with no regenerative treatment options. Unbiased RNA sequencing studies decoding the transcriptional signature of stroked tissue hold promise to identify new potential targets and pathways directed to improve treatment for stroke patients. Here, gene expression profiles of stroked tissue across different time points, species, and stroke models
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Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS J. Inflamm. (IF 5.1) Pub Date : 2023-06-08 Jennifer A. Cartwright, Joanna P. Simpson, Natalie Z. M. Homer, Adriano G. Rossi
Uncontrolled inflammation contributes to the progression of organ damage in acute conditions, such as acetaminophen-induced acute liver injury (APAP-ALI) and there are limited treatments for this condition. AT7519, a cyclic-dependent kinase inhibitor (CDKI), has been used successfully in several conditions, to resolve inflammation and return tissue homeostatic functions. AT7519 has not been assessed
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Identification and validation of biomarkers related to Th1 cell infiltration in neuropathic pain J. Inflamm. (IF 5.1) Pub Date : 2023-06-01 Xiangsheng Zhang, Jiurong Cheng, Yingdong Deng, Caiyun Guo, Yu Cao, Suo Wang, Chenxi Zhou, Ziqiang Lin, Simin Tang, Jun Zhou
Neuropathic pain (NP) is a widespread chronic pain with a prevalence of 6.9–10% in the general population, severely affecting patients’ physical and mental health. Accumulating evidence indicated that the immune environment is an essential factor causing NP. However, the mechanism is unclear. This study attempted to analyze NP-related immune infiltration patterns. We downloaded the expression profiles
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Dysregulated endothelial cell markers in systemic lupus erythematosus: a systematic review and meta-analysis J. Inflamm. (IF 5.1) Pub Date : 2023-05-16 S. C. Bergkamp, M. J. Wahadat, A. Salah, T. W. Kuijpers, V. Smith, S. W. Tas, J. M. van den Berg, S. Kamphuis, D. Schonenberg-Meinema
To perform a systematic literature review and meta-analysis on endothelial cell (EC) markers that are involved and dysregulated in systemic lupus erythematosus (SLE) in relation to disease activity, as EC dysregulation plays a major role in the development of premature atherosclerosis in SLE. Search terms were entered into Embase, MEDLINE, Web of Science, Google Scholar and Cochrane. Inclusion criteria
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Neutrophil extracellular traps in acute coronary syndrome J. Inflamm. (IF 5.1) Pub Date : 2023-05-10 Yawen Wu, Shilin Wei, Xiangyang Wu, Yongnan Li, Xue Han
Acute coronary syndrome (ACS) is a group of clinical syndromes caused by acute myocardial ischemia, which can cause heart failure, arrhythmia and even sudden death. It is the major cause of disability and death worldwide. Neutrophil extracellular traps (NETs) are reticular structures released by neutrophils activation and have various biological functions. NETs are closely related to the occurrence
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PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role J. Inflamm. (IF 5.1) Pub Date : 2023-05-02 Yinjiaozhi Li, Ruoming Tan, Ranran Li, Rui Tian, Zhaojun Liu, Xiaoli Wang, Erzhen Chen, Tingting Pan, Hongping Qu
Delayed neutrophil apoptosis during sepsis may impact neutrophil organ accumulation and tissue immune homeostasis. Elucidating the mechanisms underlying neutrophil apoptosis may help identify potential therapeutic targets. Glycolysis is critical to neutrophil activities during sepsis. However, the precise mechanisms through which glycolysis regulates neutrophil physiology remain under-explored, especially
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First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation J. Inflamm. (IF 5.1) Pub Date : 2023-05-01 Fyyaz Siddiqui, Denis Gallagher, Hannah Shuster-Hyman, Lianet Lopez, Andrée Gauthier-Fisher, Clifford L Librach
The Kynurenine Pathway (KP) of tryptophan degradation and glutamate toxicity is implicated in several neurological disorders, including depression. The therapeutic potential of mesenchymal stromal cells (MSC), owing to their well documented phagocytosis-driven mechanism of immunomodulation and neuroprotection, has been tested in many neurological disorders. However, their potential to influence KP
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Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study J. Inflamm. (IF 5.1) Pub Date : 2023-04-13 Qing Ding, Ruizhuo Zhang, Gaohong Sheng, Tianqi Wang, Shaoze Jing, Tian Ma, Shanxi Wang, Hongqi Zhao, Hua Wu, Wenkai Li
Osteoarthritis (OA) is a common joint disease and is the main cause of physical disability in the elderly. Currently, there is no adequate therapeutic strategy to reverse the progression of OA. Many natural plant extracts have received attention in the treatment of OA due to their potential anti-inflammatory properties, and reduced incidence of adverse events. Dioscin (Dio), a natural steroid saponin
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Efficacy of CU06-1004 via regulation of inflammation and endothelial permeability in LPS-induced acute lung injury J. Inflamm. (IF 5.1) Pub Date : 2023-04-06 Yeomyeong Kim, Cho-Rong Bae, Dongyeop Kim, Hyejeong Kim, Sunghye Lee, Haiying Zhang, Minyoung Noh, Young-Myeong Kim, Naoki Mochizuki, Young-Guen Kwon
Acute lung injury (ALI) is a life-threatening condition that fundamentally results from inflammation and edema in the lung. There are no effective treatments available for clinical use. Previously, we found that as a leakage blocker CU06-1004 prevents endothelial barrier disruption and enhances endothelial cell survival under inflammatory conditions. In this study, we aimed to elucidate the effect
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Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model J. Inflamm. (IF 5.1) Pub Date : 2023-03-27 Matti Hoch, Suchi Smita, Konstantin Cesnulevicius, Myron Schultz, David Lescheid, Olaf Wolkenhauer, Shailendra Gupta
Modifying the acute inflammatory response has wide clinical benefits. Current options include non-steroidal anti-inflammatory drugs (NSAIDs) and therapies that may resolve inflammation. Acute inflammation involves multiple cell types and various processes. We, therefore, investigated whether an immunomodulatory drug that acts simultaneously at multiple sites shows greater potential to resolve acute
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Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance J. Inflamm. (IF 5.1) Pub Date : 2023-03-20 Gaetano Scaramuzzo, Francesco Nucera, Alessio Asmundo, Roberto Messina, Matilde Mari, Federica Montanaro, Matt D. Johansen, Francesco Monaco, Guido Fadda, Giovanni Tuccari, Nicole G. Hansbro, Philip M. Hansbro, Trevor T. Hansel, Ian M. Adcock, Antonio David, Paul Kirkham, Gaetano Caramori, Carlo Alberto Volta, Savino Spadaro
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support. The molecular
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Anti-inflammatory activity of non-selective PDE inhibitor aminophylline on the lung tissue and respiratory parameters in animal model of ARDS J. Inflamm. (IF 5.1) Pub Date : 2023-03-16 Petra Kosutova, Pavol Mikolka, Daniela Mokra, Andrea Calkovska
Acute respiratory distress syndrome (ARDS) is a common complication of critical illness characterized by lung inflammation, epithelial and endothelial dysfunction, alveolar-capillary leakage, and worsening respiratory failure. The present study aimed to investigate the anti-inflammatory effects of non-selective phosphodiesterase (PDE) inhibitor aminophylline. New Zealand white rabbits were randomly
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Components of the sympathetic nervous system as targets to modulate inflammation – rheumatoid arthritis synovial fibroblasts as neuron-like cells? J. Inflamm. (IF 5.1) Pub Date : 2023-03-14 Xinkun Cheng, Torsten Lowin, Nadine Honke, Georg Pongratz
Catecholamines are major neurotransmitters of the sympathetic nervous system (SNS) and they are of pivotal importance in regulating numerous physiological and pathological processes. Rheumatoid arthritis (RA) is influenced by the activity of the SNS and its neurotransmitters norepinephrine (NE) and dopamine (DA) and early sympathectomy alleviates experimental arthritis in mice. In contrast, late sympathectomy
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Anti-inflammatory therapy of atherosclerosis: focusing on IKKβ J. Inflamm. (IF 5.1) Pub Date : 2023-02-23 Jiali Gan, Lin Guo, Xiaolu Zhang, Qun Yu, Qiuyue Yang, Yilin Zhang, Wenyun Zeng, Xijuan Jiang, Maojuan Guo
Chronic low-grade inflammation has been identified as a major contributor in the development of atherosclerosis. Nuclear Factor-κappa B (NF-κB) is a critical transcription factors family of the inflammatory pathway. As a major catalytic subunit of the IKK complex, IκB kinase β (IKKβ) drives canonical activation of NF-κB and is implicated in the link between inflammation and atherosclerosis, making
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Transient receptor potential melastatin 2 regulates neutrophil extracellular traps formation and delays resolution of neutrophil-driven sterile inflammation J. Inflamm. (IF 5.1) Pub Date : 2023-02-21 Xue Cao, Yanhong Li, Yubin Luo, Tianshu Chu, Hang Yang, Ji Wen, Yi Liu, Yi Zhao, Martin Herrmann
The formation of neutrophil extracellular traps (NETs) is a process releasing into the extracellular space networks of chromatin fibers decorated with granular proteins. It is implicated in infection-related as well as sterile inflammation. Monosodium urate (MSU) crystals serve as damage-associated molecular pattern (DAMP) in various conditions of disease. Formation of NETs or aggregated NETs (aggNETs)
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C57Bl/6N mice have an attenuated lung inflammatory response to dsRNA compared to C57Bl/6J and BALB/c mice J. Inflamm. (IF 5.1) Pub Date : 2023-02-21 Sofia Malm Tillgren, Juan José Nieto-Fontarigo, Samuel Cerps, Sangeetha Ramu, Mandy Menzel, Irma Mahmutovic Persson, Anja Meissner, Hamid Akbarshahi, Lena Uller
Lower respiratory infections caused by ssRNA viruses are a major health burden globally. Translational mouse models are a valuable tool for medical research, including research on respiratory viral infections. In in vivo mouse models, synthetic dsRNA can be used as a surrogate for ssRNA virus replication. However, studies investigating how genetic background of mice impacts the murine lung inflammatory
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Tofacitinib reduces acute lung injury and improves survival in a rat model of sepsis by inhibiting the JAK-STAT/NF-κB pathway J. Inflamm. (IF 5.1) Pub Date : 2023-02-03 Xinxin Zhang, Xingsheng Wang, Li Sun, Guangsheng Gao, Yun Li
Acute lung injury is a major cause of death in sepsis. Tofacitinib (TOFA), a JAK inhibitor, has anti-inflammatory activity in autoimmune diseases, but its role in acute lung injury in sepsis remains unclear. The purpose of this study is to establish a septic rat model by cecal ligation and perforation, and to evaluate the effect of tofacitinib on the survival rate of septic rat model and its role in
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Anti-inflammatory effects of β-FNA are sex-dependent in a pre-clinical model of LPS-induced inflammation J. Inflamm. (IF 5.1) Pub Date : 2023-01-25 Stephanie Myers, Kelly McCracken, Daniel J. Buck, J. Thomas Curtis, Randall L. Davis
Inflammation is present in neurological and peripheral disorders. Thus, targeting inflammation has emerged as a viable option for treating these disorders. Previous work indicated pretreatment with beta-funaltrexamine (β-FNA), a selective mu-opioid receptor (MOR) antagonist, inhibited inflammatory signaling in vitro in human astroglial cells, as well as lipopolysaccharide (LPS)-induced neuroinflammation
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Correction: Evaluation of asthma–chronic obstructive pulmonary disease overlap using a mouse model of pulmonary disease J. Inflamm. (IF 5.1) Pub Date : 2023-01-20 Yong Suk Jo, Chin Kook Rhee, Hyoung Kyu Yoon, Chan Kwon Park, Jeong Uk Lim, Tai Joon An, Jung Hur
Correction: J Inflamm 19, 25 (2022) https://doi.org/10.1186/s12950-022-00322-x Following the publication of the original article [1], the authors identified an error in the author’s name of Tai Joon An. The given name and family name were erroneously transposed. The incorrect author’s name is: An Tai Joon The correct author’s name is: Tai Joon An The author group has been updated above and the original
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Neutrophil extracellular traps and pulmonary fibrosis: an update J. Inflamm. (IF 5.1) Pub Date : 2023-01-19 Suyan Yan, Meiqi Li, Baocheng Liu, Zhenzhen Ma, Qingrui Yang
Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a significant unmet medical need. Increasing evidence indicates that neutrophil extracellular traps (NETs) contribute significantly to the progression of PF. Therefore, understanding the pathways by which NETs contribute to the disease is crucial for developing effective treatments.
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Progranulin (PGRN) as a regulator of inflammation and a critical factor in the immunopathogenesis of cardiovascular diseases J. Inflamm. (IF 5.1) Pub Date : 2023-01-19 Ali Saeedi-Boroujeni, Daryush Purrahman, Ali Shojaeian, Łukasz A. Poniatowski, Fatemeh Rafiee, Mohammad-Reza Mahmoudian-Sani
Immune dysregulation has been identified as a critical cause of the most common types of cardiovascular diseases (CVDs). Notably, the innate and adaptive immune responses under physiological conditions are typically regulated with high sensitivity to avoid the exacerbation of inflammation, but any dysregulation can probably be associated with CVDs. In this respect, progranulin (PGRN) serves as one
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Bystander effect of SARS-CoV-2 spike protein on human monocytic THP-1 cell activation and initiation of prothrombogenic stimulus representing severe COVID-19 J. Inflamm. (IF 5.1) Pub Date : 2022-12-30 Patra, Tapas, Ray, Ranjit
Hypercoagulable state and thromboembolic complications are potential life-threatening events in COVID-19 patients. Our previous studies demonstrated that SARS-CoV-2 infection as well as viral spike protein expressed epithelial cells exhibit senescence with the release of inflammatory molecules, including alarmins. We observed extracellular alarmins present in the culture media of SARS-CoV-2 spike expressing
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Efficacy of probiotic Streptococcus thermophilus in counteracting TGF-β1-induced fibrotic response in normal human dermal fibroblasts J. Inflamm. (IF 5.1) Pub Date : 2022-12-19 Lombardi, Francesca, Augello, Francesca Rosaria, Artone, Serena, Bahiti, Blerina, Sheldon, Jenna Marie, Giuliani, Maurizio, Cifone, Maria Grazia, Palumbo, Paola, Cinque, Benedetta
Abnormal and deregulated skin wound healing associated with prolonged inflammation may result in dermal fibrosis. Since the current therapeutic strategies revealed unsatisfactory, the investigation of alternative approaches such as those based on the use of specific probiotic strains could provide promising therapeutic options. In this study, we aimed to evaluate whether the lysate from S. thermophilus
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Combination of IL-17A/F and TNF-α uniquely alters the bronchial epithelial cell proteome to enhance proteins that augment neutrophil migration J. Inflamm. (IF 5.1) Pub Date : 2022-12-14 Altieri, Anthony, Piyadasa, Hadeesha, Hemshekhar, Mahadevappa, Osawa, Natasha, Recksiedler, Breann, Spicer, Victor, Hiemstra, Pieter S, Halayko, Andrew J, Mookherjee, Neeloffer
The heterodimer interleukin (IL)-17A/F is elevated in the lungs in chronic respiratory disease such as severe asthma, along with the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α). Although IL-17A/F and TNF-α are known to functionally cooperate to exacerbate airway inflammation, proteins altered by their interaction in the lungs are not fully elucidated. We used Slow Off-rate Modified Aptamer-based
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Evaluation of asthma–chronic obstructive pulmonary disease overlap using a mouse model of pulmonary disease J. Inflamm. (IF 5.1) Pub Date : 2022-12-06 Jo, Yong Suk, Rhee, Chin Kook, Yoon, Hyoung Kyu, Park, Chan Kwon, Lim, Jeong Uk, Joon, An Tai, Hur, Jung
Features of asthma and chronic obstructive pulmonary disease (COPD) can coexist in the same patient, in a condition termed asthma– chronic obstructive pulmonary disease overlap (ACO). ACO is heterogeneous condition exhibiting various combinations of asthma and COPD features. No clinically acceptable experimental model of ACO has been established. We aimed to establish an animal model of ACO. We generated
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5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages J. Inflamm. (IF 5.1) Pub Date : 2022-11-30 Liang, Panqiao, Wang, Linxin, Yang, Sushan, Pan, Xiping, Li, Jiashun, Zhang, Yuehan, Liang, Yueyun, Li, Jing, Zhou, Beixian
Acute lung injury (ALI) arises from sepsis or bacterial infection, which are life-threatening respiratory disorders that cause the leading cause of death worldwide. 5-Methoxyflavone, a methylated flavonoid, is gaining increased attention for its various health benefits. In the current study, we investigated the potential effects of 5-methoxyflavone against LPS-mediated ALI and elucidated the corresponding