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Atopic Dermatitis Phenotypes Impact Expression of Atopic Diseases Despite Similar Mononuclear Cell Cytokine Responses J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-03-02 Mohamed H. Taki, Kristine E. Lee, Ronald Gangnon, James E. Gern, Robert F. Lemanske, Daniel J. Jackson, Anne Marie Singh
The atopic march refers to the co-expression and progression of atopic diseases in childhood, often beginning with atopic dermatitis, although children may not “progress” through each atopic disease. We hypothesized that future atopic disease expression is modified by atopic dermatitis phenotype, and that these differences result from underlying dysregulation of cytokine signaling. Children (n=285)
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Loss-of-phosphorylation of IKZF1 results in gain-of-function associated with immune dysregulation J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-03-02 Akihiro Hoshino, Benoît Heid Picard, Sophia Polychronopoulou, Charikleia Kelaidi, Saba Azarnoush, Sven Kracker, Frédéric Rieux-Laucat, David Boutboul, Sylvain Latour
Immune dysregulation often presents as autoimmunity, inflammation and/or lymphoproliferation. Several germline genetic defects have been associated with immune dysregulation including heterozygous gain-of-function (GOF) mutations in , an essential transcription factor for hematopoiesis containing zinc finger domains (ZFs). However, in a large part of patients the genetic origin of their immunedysregulation
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Epithelium-derived kallistatin promotes CD4+ T cell chemotaxis to Th2-type inflammation in chronic rhinosinusitis J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-24 Lijie Jiang, Haocheng Tang, Tengjiao Lin, Yifeng Jiang, Yanmei Li, Wenxiang Gao, Jie Deng, Zhaoqi Huang, Chuxin Chen, Jianbo Shi, Ti Zhou, Yinyan Lai
The function of kallistatin in airway inflammation, particularly chronic rhinosinusitis with nasal polyps (CRSwNP), has not been elucidated. This study aimed to investigate the role of kallistatin in airway inflammation. Kallistatin and pro-inflammatory cytokine expression levels were detected in nasal polyps. For the in vivo studies, we constructed the kallistatin overexpressing transgenic mice (TG)
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Bronchiectasis and asthma: Data from The European Bronchiectasis Registry (EMBARC) J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-23 Eva Polverino, Katerina Dimakou, Letizia Traversi, Apostolos Bossios, Charles S. Haworth, Michael R. Loebinger, Anthony De Soyza, Montserrat Vendrell, Pierre-Régis Burgel, Pontus Mertsch, Melissa McDonnell, Sabina Škrgat, Luis M. Carro, Oriol Sibila, Menno van der Eerden, Paula Kauppi, Adam T. Hill, Robert Wilson, Branislava Milenkovic, Rosario Menendez, Marlene Murris, Tonia Digalaki, Megan L. Crichton
Asthma is commonly reported in patients with a diagnosis of bronchiectasis. The aim of this study was to evaluate if patients with asthma and bronchiectasis had a different clinical phenotype and different outcomes compared to patients with bronchiectasis without concomitant asthma. Prospective observational pan-European registry (EMBARC) enrolling patients across 28 countries. Adult patients with
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Machine Learning Based Identification and Characterization of Mast Cells in Eosinophilic Esophagitis J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-22 Simin Zhang, Julie M. Caldwell, Mark Rochman, Margaret H. Collins, Marc E. Rothenberg
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Increased type 1 inflammation in gynecological cervicovaginal samples in patients with APS-1 J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-21 Iivo Hetemäki, Viivi Saari, Dawit A. Yohannes, Elina Holopainen, Tiina Holster, Suvi Jokiranta, Mikko I. Mäyränpää, Seppo Virtanen, Outi Mäkitie, Eliisa Kekäläinen, Saila Laakso
Inborn errors of immunity offer important insights to mucosal immunity. In autoimmune polyendocrine syndrome type-1 (APS-1) chronic mucocutaneous candidiasis has been ascribed to neutralizing IL-17 autoantibodies. Recent evidence implicates ecxessive T-cell IFN-γ secretion ensuing epithelial barrier disruption in predisposition to candidiasis, but these results remain to be replicated. It is debated
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Airway hyperresponsiveness in asthma: the role of the epithelium J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-21 Peter Bradding, Celeste Porsbjerg, Andréanne Côté, Sven-Erik Dahlén, Teal S. Hallstrand, Christopher E. Brightling
Airway hyperresponsiveness (AHR) is a key clinical feature of asthma. The presence of AHR in people with asthma provides the substrate for bronchoconstriction in response to numerous diverse stimuli, contributing to airflow limitation and symptoms including breathlessness, wheeze and chest tightness. Dysfunctional airway smooth muscle (ASM) significantly contributes to AHR and is displayed as increased
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Navigating the blurred path of mixed neuro-immune signaling J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-17 Surbhi Gupta, Alice Viotti, Tuany Eichwald, Anais Roger, Eva Kaufmann, Rahmeh Othman, Nader Ghasemlou, Moutih Rafei, Simmie L. Foster, Sebastien Talbot
Evolution has created complex mechanisms to sense environmental danger and protect tissues, with the nervous and immune systems playing pivotal roles. These systems work together, coordinating local and systemic reflexes to restore homeostasis in response to tissue injury and infection. By sharing receptors and ligands, they influence the pathogenesis of various diseases. Recently, a less explored
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Mast Cell-Sensory Neuron Crosstalk in Allergic Diseases J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-17 Chunjing Bao, Soman N. Abraham
Mast cells (MCs) are tissue-resident immune cells, well-positioned at the host-environment interface for detecting external antigens and playing a critical role in mobilizing innate and adaptive immune responses. Sensory neurons are afferent neurons innervating most areas of the body but especially in the periphery, where they sense external and internal signals and relay information to the brain.
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Epithelial-neuronal-immune cell interactions: implications for immunity, inflammation, and tissue homeostasis at mucosal sites J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-16 Elizabeth Emanuel, Mohammad Arifuzzaman, David Artis
The epithelial lining of the respiratory tract and intestine provides a critical physical barrier to protect host tissues against environmental insults including dietary antigens, allergens, chemicals, and microorganisms. In addition, specialized epithelial cells directly communicate with hematopoietic and neuronal cells. These epithelial-immune and epithelial-neuronal interactions control host immune
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A quantitative systems pharmacology workflow towards optimal design and biomarker stratification of atopic dermatitis clinical trials J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-16 Natacha Go, Simon Arsène, Igor Faddeenkov, Théo Galland, Shiny Martis B., Diane Lefaudeux, Yishu Wang, Loic Etheve, Evgueni Jacob, Claudio Monteiro, Jim Bosley, Caterina Sansone, Christian Pasquali, Lorenz Lehr, Alexander Kulesza
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The Immune System in Neurological Diseases: What Innate-like T Cells have to Say J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-15 Season K. Wyatt-Johnson, Reham Afify, Randy R. Brutkiewicz
The immune system classically consists of two lines of defense: innate and adaptive, both of which interact with one another effectively to protect us against any pathogenic threats. Importantly, there is a diverse subset of cells known as innate-like T cells that act as a bridge between the innate and adaptive immune systems and are pivotal players in eliciting inflammatory immune responses. A growing
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Accurate determination of house dust mite sensitization in asthma and allergic rhinitis through cytometric detection of Der p 1 and Der p 2 binding on Basophils (CytoBas) J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-14 Lin Hsin, Nirupama Varese, Pei Mun Aui, Bruce D. Wines, Anouk von Borstel, Laurent Mascarell, P. Mark Hogarth, Mark Hew, Robyn E. O’Hehir, Menno C. van Zelm
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Update on Asthma Biology J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-09 Steve N. Georas, Sandhya Khurana
This is an exciting time to be conducting asthma research. The recent development of targeted asthma biologics has validated the power of basic research to discover new molecules amenable to therapeutic intervention. Advances in high throughput sequencing are providing a wealth of “-omic” data about genetic and epigenetic underpinnings of asthma, as well as new cellular interacting networks and potential
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Genetic, Immunological, and Clinical Features of 830 Patients with Mendelian Susceptibility to Mycobacterial Diseases (MSMD): A Systematic Review J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-08 Armin Khavandegar, Seyed Alireza Mahdaviani, Majid Zaki-Dizaji, Fereshteh Khalili-Moghaddam, Sarina Ansari, Saba Alijani, Nooshin Taherzadeh-Ghahfarrokhi, Davood Mansouri, Jean-Laurent Casanova, Jacinta Bustamante, Mahnaz Jamee
Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare clinical syndrome characterized by vulnerability to weakly virulent mycobacterial species, including Bacillus Calmette-Guérin (BCG) vaccines and environmental mycobacteria. We performed a systematic review of the genetic, immunological, and clinical findings for reported MSMD patients. We searched PubMed, Web of Science, and Scopus
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Basophils are important for the development of allergic skin inflammation. J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-07 Juan-Manuel Leyva-Castillo, Daniela Vega-Mendoza, Maria Strakosha, Liwen Deng, Samantha Choi, Kensuke Miyake, Hajime Karasuyama, Isaac M. Chiu, Wanda Phipatanakul, Raif S. Geha
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IgE+ PCs arise in lung draining lymph nodes during HDM exposure, acquire distinct phenotypes over time and accumulate in the bone marrow after chronic allergic inflammation J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Andrea Vecchione
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Treatment Strategies For Eosinophilic Esophagitis. Our Experience. J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Alejandra Jover-Walsh, Gema Salas-Parra, Gabriela Zambrano Ibarra, Elena Rodriguez Mazariego
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Cashew Oral Immunotherapy Outcomes in Infants and Toddlers J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Samantha Jacobs, Amanda Cox, Jacob Kattan, Scott Sicherer, Angela Tsuang, Marion Groetch, Allison Schaible, Ami Shah, Roxanne Oriel
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Dysregulated nasal mucosal antiviral transcriptome in young children with problematic wheeze infected with rhinovirus (RV) J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Larry Borish, Ava Noth, Stella Kellams, Kristin Wavell, Elaine Etter, Cameron Griffiths, Monica Lawrence, Ryan Sessuns, Gerald Teague
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Long-Term Safety of Mepolizumab in EGPA: Results From the Long-Term Access Programme J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Paneez Khoury, Jared Silver, Gerhard Wolff, Rejina Verghis, Michael Wechsler
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SISTEMIC AND TOPIC ALLERGY TO CORTICOSTEROIDS: OUR EXPERIENCE J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Diana Perez Alzate, Natalia Blanca-López, Isabel torres, Paula López, Ana Moreno-Prieto Pfeifer, Francisco Javier Ruano
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Effects of Airborne Fungal Diversity in Urban forest on Allergic Inflammation J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Young Yoo, Wonsuck Yoon, Yongsung Park, Soonhyun Kwon
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Ineligibility for Drug Reimbursement Implies Inferior Outcomes in Chronic Spontaneous Urticaria: A Hidden Source of Disparities J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Hugo Mak, Valerie Chiang, Elsie Chan, Elaine Lee, Jackie Yim, Dorothy Lam, Philip Li
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Clinical and Mechanistic Findings from MOTIF Trial: A Phase 2 Study Using Food Allergen Oral Immunotherapy for Cashew or Shrimp Allergy J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Andrea Fernandes, Shu Cao, Ella Parsons, Dinara Bogetic, Divya Kumar, Jessica Rogers, Debjani Ghoshal, Julia Thompson, Shu-Chen Lyu, Diane Dunham, Evan Do, Sofia Maysel-Auslender, Taryn Liu, Reyna Sharma, Andrew Chin, Andrew Long, Sheena Gupta, Kristine Martinez, Monali Manohar, Manisha Desai, Holden Maecker, Kari Nadeau, Sharon Chinthrajah, Sayantani Sindher
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Comorbid Contributions to the 10-Year Intra-Individual Variance of Blood Eosinophil Counts in Inner-City Asthmatics J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Ji Won Lee, Brian Patchett, Ruchi Patel, Joshua Palma, Arash Nikjoo, Christine Song, Fatima Vandi, Charles Cairns, Edward Schulman
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Evaluation of Physical Properties and Agreement between Fresh Boiled Egg and Freeze-dried Preparation for Skin Testing in Children Suspected Egg Allergy J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Yada Sirisa, Puttatida Chetwong, Natsaran Meprayoonwong, Suvimol Charoensiddhi, Wasaporn Chanput, Rapisa Nantanee, Pannipa Kittipongpattana, Supatcharee Siriwong, Stephen Kerr, Pantipa Chatchatee, Narissara Suratannon
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Early Peanut Introduction and Sources of Information amongst Parent/Caregivers J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Waheeda Samady, Hodan Jibrell, Madeleine Davison, Corwin Rolling, Ruchi Gupta
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Dupilumab Use in Patients with Hypereosinophilic Syndrome: A Multi-Center Case Series J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Ejiofor Ezekwe, Andrew Weskamp, Paneez Khoury, Gregory Constantine, Nathan Boggs, Amy Klion
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The Temporal Trends of Peanut Anaphylaxis Rates in a Pediatric Emergency Department in Montreal, Canada, Following Early Peanut Introduction Guidelines J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Derek Lanoue, Joshua Yu, Adhora Mir, Mohammed Kaouache, Adam Bretholz, Ann Clarke, Christine McCusker, Jennifer Protudjer, Moshe Ben-Shoshan
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Characteristics of patients with hypereosinophilic syndrome in a large US cohort J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Donna Carstens, Princess Ogbogu, Yen Chung, Mu Cheng, Erin Cook, Fan Mu, Elizabeth Judson, Jingyi Chen, Travis Wang, Zhuo Chen, Paneez Khoury
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Qualitative Review of Psychosocial Recommendations for Families Considering Oral Immunotherapy J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Sara Voorhees, Nancy Rotter, Chen Rosenberg, Deborah Friedman
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Distinct metabolomic profiles are associated with changes over time and sustained unresponsiveness in children on peanut oral immunotherapy J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Jennifer Styles, Sarita Patil, Bert Ruiter, Neal Smith, Clary Clish, Jessica Lasky-Su, Wayne Shreffler, Yamini Virkud
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Educación Es Poder: A QI Project Addressing Food Allergy Education in Hispanic Patients J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Ana Luiza Graneiro, Vivian Hernandez-Trujillo
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Evaluating the Impact of a Specialty Pharmacy-Based Navigation Intervention on Access to Biologics in Patients with Moderate-to-Severe Asthma in Bronx, NY J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Thomas Scharfenberger, Xiaojia Wang, Sunit Jariwala
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Tongue Angioedema After The Emergency Department J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Alba Juárez, Gema Salas, Alejandra Jover, Ana Láinez, Dasha Roa, María Baeza
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Blocking CD226 regulates ILC2 effector function and alleviates airway hyperreactivity J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Yoshihiro Sakano, Kei Sakano, Benjamin Hurrell, Doumet Helou, Pedram Shafiei-Jahani, Mohammad Kazemi, Xin Li, Stephen Shen, Richard Barbers, Omid Akbari
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Bacterial load of non-lesional skin on pediatric atopic dermatitis and food allergy J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Arya Dahal, Wan Chi Chang, Brittany Grashel, David Morgan, Jocelyn Biagini, Gurjit Khurana Hershey
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PREPARE: A Pilot RCT in Perioperative Penicillin and Cephalosporin Antibiotic Allergy Assessment and Testing J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Joseph De Luca, Sara Vogrin, Natasha Holmes, Jamie Waldron, Fionnuala Cox, Justin Nazareth, Ranjan Guha, Ned Douglas, Andrew Hardidge, Jo Douglass, Trisha Peel, Douglas Johnson, Jason Trubiano
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Patient characteristics in pediatric eosinophilic esophagitis in Dupilumab and non Dupilumab treated cohorts J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Wyatt Verplaetse, Brooke Polk
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A Phase 2/3 Study To Assess The Efficacy And Safety Of Dupilumab Versus Placebo In Adults And Adolescents With Eosinophilic Gastritis With Or Without Eosinophilic Duodenitis J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Evan Dellon, Marc Rothenberg, Mirna Chehade, Eric Mortensen, Elizabeth Laws, Jennifer Maloney, Renata Martincova, Heather Paleczny, Lila Glotfelty, Arsalan Shabbir
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Analysis of Children and Adolescents with Diagnosis of Cashew Nut Allergy J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Jay Jeffers, Hakan Dokmeci
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Pragmatic Removal of Penicillin Electronic Health Record Labels: The PROPEL Trial J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Joanna Stollings, Heather Prigmore, Allison McCoy, Mary Lynn Dear, William Hiser, Grace Van Winkle, Todd Rice, Chris Lindsell, Elizabeth Phillips, Cosby Stone
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Dupilumab Is Efficacious Up To 52 Weeks In Patients With Eosinophilic Esophagitis Irrespective Of Prior Food Elimination Diet Or History Of Food Allergy J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Jonathan Spergel, Marc Rothenberg, Antonella Cianferoni, Changming Xia, Lila Glotfelty, Arsalan Shabbir
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Grass Allergy and Risk of Anaphylaxis During Subcutaneous Immunotherapy J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Ethan Canty, Jeffrey Yung, Toan Do, Shyam Joshi
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Cost Barriers as Factors Associated with Poor Asthma Control in the United States – Findings from Child Asthma Call Back Survey J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Wimwipa Mongkonsritragoon, Devika Pillay, Jenny Huang, Pavadee Poowuttikul
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Food prescription for food insecurity and food allergens improves food insecurity among families J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Sayantani Sindher, Julia Thompson, Dinara Bogetic, Shu Cao, Marleni Albarran, Kristine Martinez, Andrew Chin, Christopher Warren, R. Sharon Chinthrajah
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Direct Oral Challenge for Low-Risk Sulfonamide Allergy: Safety and Antimicrobial Stewardship Impacts in Hospitalised Patients J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Elise Mitri, Jamie Waldron, Fionnuala Cox, Kyra Chua, Rebecca Hall, Kerryn McInnes, Natasha Holmes, Jason Trubiano
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Outcomes of T Cell Receptor Excision Circle (TREC) Based Severe Combined Immunodeficiency (SCID) Newborn Screening (NBS) in Michigan: 10 Year Data J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Devika Pillay, Aishwarya Navalpakam, Rebecca Shaulis, Mary Rhuehle, Isabel Hurden, Jenny Huang, Pavadee Poowuttikul
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Novel Strategy for Delabeling Chlorhexidine Allergy Utilizing the Online Patient Portal at a Pediatric Hospital J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Margaret Roth, Rosemary Moak, Hadassah Little, Allison Eckard, Elizabeth Mack, Kelli Williams
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Development of A Novel Oral Treatment for Atopic Dermatitis J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Michelle Meyer, Daniel Webb, Douglas Stafford, Leggy Arnold
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Efficacy and safety of simultaneous multiple food sublingual immunotherapy in polysensitized food allergic pediatric patients J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Nicholas Klaiber, Elizabeth Wahlin
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Does Distraction Do Anything? Assessing the Effectiveness of Introducing a Distraction Task During Skin Testing to Pediatric Patients to Decrease Distress J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Nandini Kohli, Jason Ohayon, Stephanie Raptis, Vaidehi Bhatt
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Impact of Mepolizumab on Sleep Disturbance in Patients With Chronic Rhinosinusitis With Nasal Polyps and/or Asthma: Analysis From SYNAPSE and MUSCA J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Peter Howarth, Joaquim Mullol, Claus Bachert, Wytske Fokkens, Steven Smith, Tom Keeley, Lingjiao Zhang, Robert Chan
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A Pilot Study Testing Adherence to Multiple Digital Health Tools among Adolescents with Asthma J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Jeremy Owens, Katherine Mills, Jeffrey Barahona, Edgar Lobaton, Delesha Carpenter, Alper Bozkurt, Michelle Hernandez
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Venom component testing in the allergist office: a description of 27 North American patients J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Theodore Kelbel, Connor Kuipers
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Do Numbers Matter? Assessing Influence Of Number Of Food Allergies (FA) In Patients' Long Term Management Of Their Eating Practices and Allergy Treatment. J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Gurnidhi Binner, Jason Ohayon
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Characteristics of Chronic Urticaria in Patients from the Republic of Kazakhstan J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2024-02-05 Zhanat Ispayeva, Raikhan Bekmagambetova, Adilet Bostanov, Aigerim Zhakiyeva, Munira Zairova, Lawrence Dubuske