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The abnormal signaling of the B cell receptor and co-receptors of lupus B cells Clin. Immunol. (IF 8.6) Pub Date : 2024-04-16 Stamatis-Nick C. Liossis
It is easily understood that studying the physiology and pathophysiology of the BCRtriggered cascade is of importance, particularly in such diseases as systemic lupus erythematosus (SLE) that are considered by many as a “B cell disease”. Even though B cells are not considered as the only players in lupus pathogenesis, and other immune and non-immune cells are certainly involved, it is the success of
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S. aureus biofilm properties correlate with immune B cell subset frequencies and severity of chronic rhinosinusitis Clin. Immunol. (IF 8.6) Pub Date : 2024-04-16 Gohar Shaghayegh, Clare Cooksley, George Bouras, Beula Subashini Panchatcharam, Sholeh Feizi, Shari Javadian, Mahnaz Ramezanpour, Kevin Aaron Fenix, Peter-John Wormald, Alkis James Psaltis, Sarah Vreugde
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Single-cell sequencing reveals distinct immune cell features in cutaneous lesions of pemphigus vulgaris and bullous pemphigoid Clin. Immunol. (IF 8.6) Pub Date : 2024-04-15 Zhi Hu, Meiling Zheng, Ziyu Guo, Wenhui Zhou, Wenyu Zhou, Nan Yao, Guiying Zhang, Qianjin Lu, Ming Zhao
Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are two common subtypes of autoimmune bullous disease (AIBD). The key role of circulating autoreactive immune cells contributing to skin damage of AIBD has been widely recognized. Nevertheless, the immune characteristics in cutaneous lesions remain unclear. Here, we performed single-cell RNA sequencing (scRNA-seq) and single-cell VDJ sequencing (scRNA-seq)
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Wiskott Aldrich syndrome protein (WASp)-deficient Th1 cells promote R-loop-driven transcriptional insufficiency and transcription-coupled nucleotide excision repair factor (TC-NER)-driven genome-instability in the pathogenesis of T cell acute lymphoblastic leukemia Clin. Immunol. (IF 8.6) Pub Date : 2024-04-04 Pradeep R, Sudeshna Rakshit, Geetha Shanmugam, Melvin George, Koustav Sarkar
T-ALL is an aggressive hematological tumor that develops as the result of a multi-step oncogenic process which causes expansion of hematopoietic progenitors that are primed for T cell development to undergo malignant transformation and growth. Even though first-line therapy has a significant response rate, 40% of adult patients and 20% of pediatric patients will relapse. Therefore, there is an unmet
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New and emerging therapies for systemic lupus erythematosus Clin. Immunol. (IF 8.6) Pub Date : 2024-04-04 Eleni Papachristodoulou, Vasileios C. Kyttaris
Systemic Lupus Erythematosus (SLE) and lupus nephritis treatment is still based on non-specific immune suppression despite the first biological therapy for the disease having been approved more than a decade ago. Intense basic and translational research has uncovered a multitude of pathways that are actively being evaluated as treatment targets in SLE and lupus nephritis, with two new medications receiving
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Integration of metalloproteome and immunoproteome reveals a tight link of iron-related proteins with COVID-19 pathogenesis and immunity Clin. Immunol. (IF 8.6) Pub Date : 2024-04-02 Ying Zhou, Tianfan Cheng, Kaiming Tang, Hongyan Li, Cuiting Luo, Fu Yu, Fan Xiao, Lijian Jin, Ivan Fan-Ngai Hung, Liwei Lu, Kwok-Yung Yuen, Jasper Fuk-Woo Chan, Shuofeng Yuan, Hongzhe Sun
Increasing clinical data show that the imbalance of host metallome is closely associated with different kinds of disease, however, the intrinsic mechanisms of action of metals in immunity and pathogenesis of disease remain largely undefined. There is lack of multiplexed profiling system to integrate the metalloproteome-immunoproteome information at systemic level for exploring the roles of metals in
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Increased AXLhigh myeloid cells as pathognomonic marker in Langerhans cell histiocytosis and Langerin expression dependence of mTOR inhibition Clin. Immunol. (IF 8.6) Pub Date : 2024-04-02 Cinthia Mariel Olexen, Denise Risnik, María Catalina Lava, Guido Luis Dalla Vecchia, Diego Alfredo Rosso, Andrea Emilse Errasti, Eugenio Antonio Carrera Silva
Langerhans cell histiocytosis (LCH) is characterized by an expansion and accumulation of pathological histiocytes expressing langerin (CD207) and CD1a in different organs under an inflammatory milieu. The origin of pathognomonic precursors of LCH is widely debated, but monocytes and pre-dendritic cells (pre-DC) play a significant role. Remarkably, we found an expansion of AXL cells in the CD11c subset
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Duodenal mucosa of untreated celiac disease patients has altered expression of the GAS6 and PROS1 and the negative regulator tyrosine kinase TAM receptors subfamily Clin. Immunol. (IF 8.6) Pub Date : 2024-04-02 Federico Perez, María Luz Iribarren, Cinthia Mariel Olexen, Carolina Naymé Ruera, Andrea Emilse Errasti, Luciana Guzman, Laura Garbi, Eugenio Antonio Carrera Silva, Fernando Gabriel Chirdo
Celiac disease (CD) is an immune-driven disease characterized by tissue damage in the small intestine of genetically-susceptible individuals. We evaluated here a crucial immune regulatory pathway involving TYRO3, AXL, and MERTK (TAM) receptors and their ligands PROS1 and GAS6 in duodenal biopsies of controls and CD patients. We found increased GAS6 expression associated with downregulation of PROS1
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Identification of connective tissue disease autoantibodies and a novel autoantibody anti-annexin A11 in patients with “idiopathic” interstitial lung disease Clin. Immunol. (IF 8.6) Pub Date : 2024-04-02 Sarah L. Tansley, Fionnuala McMorrow, Caroline V. Cotton, Huzaifa Adamali, Shaney L. Barratt, Zoe E. Betteridge, Janire Perurena-Prieto, Michael A. Gibbons, Raman Kular, Aravinthan Loganathan, Janine A. Lamb, Hui Lu, Robert P. New, Diane Pratt, Pilar Rivera-Ortega, Ross Sayers, Matthew Steward, Lachlan Stranks, Edward Vital, Lisa G. Spencer, Neil J. McHugh, Robert G. Cooper, the UK-BILD Collaboration
Autoantibodies are a hallmark feature of Connective Tissue Diseases (CTD). Their presence in patients with idiopathic interstitial lung disease (ILD) may suggest covert CTD. We aimed to determine the prevalence of CTD autoantibodies in patients diagnosed with idiopathic ILD. 499 patient sera were analysed: 251 idiopathic pulmonary fibrosis (IPF), 206 idiopathic non-specific interstitial pneumonia (iNSIP)
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Methylation levels of the IL10 gene in peripheral blood are related to the intractability of Graves' disease Clin. Immunol. (IF 8.6) Pub Date : 2024-04-01 Riku Kinoshita, Naoya Inoue, Yoshinori Iwatani, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe
The prognosis of autoimmune thyroid diseases (AITDs), including Hashimoto's disease (HD) and Graves' disease (GD), is difficult to predict. DNA methylation regulates gene expression of immune mediating factors. Interleukin (IL)-10 is a Th2 cytokine that downregulates inflammatory cytokines produced by Th1 cells. To clarify the role of methylation of the gene in the prognosis of AITD, we evaluated the
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Macrophage migration inhibitory factor mediates skin aging via CD74: Insights from single-cell and bulk RNA sequencing data Clin. Immunol. (IF 8.6) Pub Date : 2024-03-31 Songjiang Wu, Yujie Ouyang, Yibo Hu, Ling Jiang, Chuhan Fu, Li Lei, Yushan Zhang, Haoran Guo, Jinhua Huang, Jing Chen, Qinghai Zeng
Cell-cell communication is crucial for regulating signaling and cellular function. However, the precise cellular and molecular changes remain poorly understood in skin aging. Based on single-cell and bulk RNA data, we explored the role of cell-cell ligand-receptor interaction in skin aging. We found that the macrophage migration inhibitory factor (MIF)/CD74 ligand-receptor complex was significantly
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Retraction notice to “Glycogen synthase kinase-3β inhibition attenuates the degree of arthritis caused by type II collagen in the mouse” [Clin. Immunol. 120/1 (2006) 57–67] Clin. Immunol. (IF 8.6) Pub Date : 2024-03-29 Salvatore Cuzzocrea, Emanuela Mazzon, Rosanna Di Paola, Carmelo Muià, Concetta Crisafulli, Laura Dugo, Marika Collin, Domenico Britti, Achille P. Caputi, Christoph Thiemermann
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Retraction notice to “Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody” [Clin. Immunol. 113/1 (2004) 64–73] Clin. Immunol. (IF 8.6) Pub Date : 2024-03-29 Rosanna Di Paola, Roberto Di Marco, Emanuela Mazzon, Tiziana Genovese, Klaus Bendtzen, Battesimo Macri, Ferdinando Nicoletti, Salvatore Cuzzocrea
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Type I interferon associated epistasis may contribute to early disease-onset and high disease activity in juvenile-onset lupus Clin. Immunol. (IF 8.6) Pub Date : 2024-03-18 Yves Renaudineau, Amandine Charras, Valentina Natoli, Mathieu Fusaro, Eve M.D. Smith, Michael W. Beresford, Christian M. Hedrich, on behalf of the UK jSLE Cohort Study
Pathologic type I interferon (T1IFN) expression is a key feature in systemic lupus erythematosus (SLE) that associates with disease activity. When compared to adult-onset disease, juvenile-onset (j)SLE is characterized by increased disease activity and damage, which likely relates to increased genetic burden. To identify T1IFN-associated gene polymorphisms (, , /miR-146a, , , , , , ), identify long-range
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CD32 (FcγRIIB) expression is low on CD21low B cells from systemic sclerosis patients with digital ulcers, interstitial lung disease, and anti-topoisomerase I autoantibodies Clin. Immunol. (IF 8.6) Pub Date : 2024-03-15 Evangeli Kourkouni, Sotirios G. Tsiogkas, Athanasios Mavropoulos, Theodora Simopoulou, Christina G. Katsiari, Dimitrios P. Bogdanos, Lazaros I. Sakkas
CD21 B cells have recently been found increased in SSc-associated digital ulcers (DUs) or interstitial lung disease (ILD). To further characterize CD21 B cells which encompass autoreactive cells, we analyzed their expression of the inhibitory CD32 receptor in SSc. Peripheral blood mononuclear cells from 27 patients with SSc and 15 age-and sex-matched healthy controls (HCs) were analyzed with multicolor
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First validation of the childhood lupus low disease activity state (cLLDAS) definition in a real-life longitudinal cSLE cohort Clin. Immunol. (IF 8.6) Pub Date : 2024-03-14 Sandy C. Bergkamp, Thipa Kanagasabapathy, Mariken P. Gruppen, Taco W. Kuijpers, Amara Nassar - Sheikh Rashid, J. Merlijn van den Berg, Dieneke Schonenberg-Meinema
To validate the childhood lupus low disease activity state (cLLDAS) definition in cSLE by describing differences in time to reach first adult LLDAS (aLLDAS) versus cLLDAS. Secondly, to analyse positive and negative predictors for maintaining cLLDAS for at least 50% of follow-up time (cLLDAS-50) and for the occurrence of damage. Prospective longitudinal data from a cSLE cohort were analysed. Used definitions
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From homeostasis to defense: Exploring the role of selective autophagy in innate immunity and viral infections Clin. Immunol. (IF 8.6) Pub Date : 2024-03-11 Mengyao Huang, Wei Zhang, Yang Yang, Wenhua Shao, Jiali Wang, Weijun Cao, Zixiang Zhu, Fan Yang, Haixue Zheng
The process of autophagy, a conservative evolutionary mechanism, is responsible for the removal of surplus and undesirable cytoplasmic components, thereby ensuring cellular homeostasis. Autophagy exhibits a remarkable level of selectivity by employing a multitude of cargo receptors that possess the ability to bind both ubiquitinated cargoes and autophagosomes. In the context of viral infections, selective
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The immune cell transcriptome is modulated by vitamin D3 supplementation in people with a first demyelinating event participating in a randomized placebo-controlled trial Clin. Immunol. (IF 8.6) Pub Date : 2024-03-11 Wei Zhen Yeh, Melissa Gresle, Rodney Lea, Bruce Taylor, Robyn M. Lucas, Anne-Louise Ponsonby, Deborah Mason, Julie Andrew, Hamish Campbell, Julia Morahan, Sandeep Sampangi, Maria Pia Campagna, Jim Stankovich, Anneke Van der Walt, Vilija Jokubaitis, Helmut Butzkueven
Vitamin D deficiency is a risk factor for developing multiple sclerosis. The PrevANZ trial was conducted to determine if vitamin D supplementation can prevent recurrent disease activity in people with a first demyelinating event. As a sub-study of this trial, we investigated the effect of supplementation on peripheral immune cell gene expression. Participants were randomized to 1000, 5000 or 10,000
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The role of podocytes in lupus nephritis: Insights and implications Clin. Immunol. (IF 8.6) Pub Date : 2024-03-09 Kunihiro Ichinose
Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus, with high mortality rates despite medical advancements. The complexity of its pathogenesis, including the pivotal role of podocytes — kidney-localized cells — remains a challenge, lacking effective treatments and biomarkers. Recent studies highlight the significant contribution of these cells to LN's development, particularly
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The role of cAMP dependent gene transcription in lupus pathophysiology Clin. Immunol. (IF 8.6) Pub Date : 2024-03-08 Rauen Thomas, Tenbrock Klaus
T lymphocytes play a major role in the pathophysiology of systemic lupus erythematosus. T cellular dysregulation includes significant alterations in signal transduction, cytokine production and metabolic pathways. The cAMP dependent transcription factors like CREB and CREM exert pleiotropic functions as they are critically involved in epigenetic conformational changes and gene regulation of different
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The critical role of RAGE in severe influenza infection: A target for control of inflammatory response in the disease Clin. Immunol. (IF 8.6) Pub Date : 2024-03-08 Wenhui Guo, Junhao Luo, Song Zhao, Li Li, Wenge Xing, Rongbao Gao
Controlling the excessive inflammatory response is one of the key ways to reduce the severity and mortality of severe influenza virus infections. RAGE is involved in inflammatory responses and acute lung injuries. Here, we investigated the role of RAGE and its potential application as a target for severe influenza treatment through serological correlation analysis for influenza patients, and treatment
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Understanding the pathogenic significance of altered calcium-calmodulin signaling in T cells in autoimmune diseases Clin. Immunol. (IF 8.6) Pub Date : 2024-03-08 Tomohiro Koga
Calcium/calmodulin-dependent protein kinase IV (CaMK4) serves as a pivotal mediator in the regulation of gene expression, influencing the activity of transcription factors within a variety of immune cells, including T cells. Altered CaMK4 signaling is implicated in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and psoriasis, which are characterized by dysregulated
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APDS patients with immune-complex vasculitis and resolution with leniolisib Clin. Immunol. (IF 8.6) Pub Date : 2024-03-08 Mohammad-Ali Doroudchi, Alexis V. Stephens, Ziwei Wang, Jaspreet Dhami, Manish J. Butte
Activated phosphoinositide 3-kinase delta syndrome (APDS) is an inborn error of immunity with heterogeneous clinical manifestations of infections, immune dysregulation, autoimmunity; lymphoproliferation; and malignancy. Immune complex-mediated vasculitides have not yet been described in APDS patients. Here we offer a case series of three patients with APDS who have refractory IgA vasculitis (also called
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Deep immune profiling of chronic rhinosinusitis in allergic and non-allergic cohorts using mass cytometry Clin. Immunol. (IF 8.6) Pub Date : 2024-03-08 Fana Alem Kidane, Lena Müller, Marianne Rocha-Hasler, Aldine Tu, Victoria Stanek, Nicholas Campion, Tina Bartosik, Mohammed Zghaebi, Slagjana Stoshikj, Daniela Gompelmann, Andreas Spittler, Marco Idzko, Julia Eckl-Dorna, Sven Schneider
Chronic rhinosinusitis (CRS) is a persistent nasal and paranasal sinus mucosa inflammation comprising two phenotypes, namely CRS with nasal polyps (CRSwNP) and without (CRSsNP). CRSwNP can be associated with asthma and hypersensitivity to non-steroidal anti-inflammatory drug (NSAID) in a syndrome known as NSAID-exacerbated respiratory disease (N-ERD). Furthermore, CRS frequently intertwines with respiratory
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Intestinal permeability correlates with disease activity and DNA methylation changes in lupus patients Clin. Immunol. (IF 8.6) Pub Date : 2024-03-08 Mckenna M. Bowes, Desiré Casares-Marfil, Amr H. Sawalha
Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease that can involve various organ systems. Several studies have suggested that increased intestinal permeability may play a role in the pathogenesis of lupus. The aim of this study was to elucidate the relationship between intestinal permeability, disease activity, and epigenetic changes in lupus patients. A total of 25 female
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From mice to men: An assessment of preclinical model systems for the study of vitiligo Clin. Immunol. (IF 8.6) Pub Date : 2024-03-08 Wei Wu, Xinju Wang, Kaiqiao He, Chunying Li, Shuli Li
Vitiligo is an autoimmune skin disease of multiple etiology, for which there is no complete cure. This chronic depigmentation is characterized by epidermal melanocyte loss, and causes disfigurement and significant psychosocial distress. Mouse models have been extensively employed to further our understanding of complex disease mechanisms in vitiligo, as well as to provide a preclinical platform for
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Tumor-necrosis factor α-rich environment alters type-I interferon response to viral stimuli in patients with juvenile idiopathic arthritis by altering myeloid dendritic cell phenotype Clin. Immunol. (IF 8.6) Pub Date : 2024-03-08 Irena Zentsova, Adam Klocperk, Marketa Bloomfield, Helena Kubesova, Hana Malcova, Dita Cebecauerova, Rudolf Horvath, Anna Sediva, Zuzana Parackova
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Functional consequence of Iron dyshomeostasis and ferroptosis in systemic lupus erythematosus and lupus nephritis Clin. Immunol. (IF 8.6) Pub Date : 2024-03-07 Laurence Morel, Yogesh Scindia
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The landscape of immune dysregulation in pediatric sepsis at a single-cell resolution Clin. Immunol. (IF 8.6) Pub Date : 2024-03-07 Fahd Alhamdan, Sophia Koutsogiannaki, Koichi Yuki
Recognizing immune dysregulation as a hallmark of sepsis pathophysiology, leukocytes have attracted major attention of investigation. While adult and pediatric sepsis are clinically distinct, their immunological delineation remains limited. Single cell technologies facilitated the characterization of immune signatures. We tackled to delineate immunological profiles of pediatric sepsis at a single-cell
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A Disintegrin and metalloproteinase carves T cell abnormalities and pathogenesis in systemic lupus erythematosus Clin. Immunol. (IF 8.6) Pub Date : 2024-03-07 Masataka Umeda, Abhigyan Satyam, Nobuya Yoshida, Atsushi Kawakami
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder impacting various organs, notably prevalent in women of reproductive age. This review explores the involvement of a disintegrin and metalloproteinases (ADAMs) in SLE pathogenesis. Despite advancements in understanding SLE through genome and transcriptome studies, the role of ADAMs in post-translational regulations remains insufficiently
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Novel therapeutic strategies targeting abnormal T-cell signaling in systemic lupus erythematosus Clin. Immunol. (IF 8.6) Pub Date : 2024-03-06 Masayuki Mizui, Michihito Kono
Therapeutic strategies for autoimmune diseases have been based on the use of glucocorticoids and immunosuppressive agents that broadly suppress immune responses. Therefore, organ damage from long-term use and infections due to immunocompromised status have been significant issues. Safer immunosuppressants and biological agents are now available, but there is still an urgent need to develop specific
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LXA4 protected mice from renal ischemia/reperfusion injury by promoting IRG1/Nrf2 and IRAK-M-TRAF6 signal pathways Clin. Immunol. (IF 8.6) Pub Date : 2024-03-05 Hongtao Tie, Ge Kuang, Xia Gong, Lidan Zhang, Zizuo Zhao, Shengwang Wu, Wenya Huang, Xiahong Chen, Yinglin Yuan, Zhenhan Li, Hongzhong Li, Li Zhang, Jingyuan Wan, Bin Wang
Excessive inflammatory response and increased oxidative stress play an essential role in the pathophysiology of ischemia/reperfusion (I/R)-induced acute kidney injury (IRI-AKI). Emerging evidence suggests that lipoxin A4 (LXA4), as an endogenous negative regulator in inflammation, can ameliorate several I/R injuries. However, the mechanisms and effects of LXA4 on IRI-AKI remain unknown. In this study
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Involvement of autologous myeloid dendritic cells in the evaluation of immediate hypersensitivity reactions to betalactams Clin. Immunol. (IF 8.6) Pub Date : 2024-03-02 Ruben Fernandez-Santamaria, Adriana Ariza, Gador Bogas, Maria Salas, Silvia Calvo-Serrano, Cecilia Frecha, Cristobalina Mayorga, Maria Jose Torres, Tahia Diana Fernandez
Amoxicillin (AX) and clavulanic acid (CLV) are the betalactam antibiotics (BLs) most used to treat bacterial infections, although they can trigger immediate hypersensitivity reactions (IDHRs). The maturation analysis of monocyte-derived dendritic cells (moDCs) and their capacity to induce proliferative response of lymphocytes are useful to test the sensitisation to a drug, although without optimal
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Tracking the immune response profiles elicited by the BNT162b2 vaccine in COVID-19 unexperienced and experienced individuals Clin. Immunol. (IF 8.6) Pub Date : 2024-02-28 Eugenia Galeota, Valeria Bevilacqua, Andrea Gobbini, Paola Gruarin, Mauro Bombaci, Elisa Pesce, Andrea Favalli, Andrea Lombardi, Francesca Vincenti, Jessica Ongaro, Tanya Fabbris, Serena Curti, Martina Martinovic, Mirco Toccafondi, Mariangela Lorenzo, Angelica Critelli, Francesca Clemente, Mariacristina Crosti, Maria Lucia Sarnicola, Manuele Martinelli, Lucia La Sala, Alejandro Espadas, Lorena Donnici
Multiple vaccines have been approved to control COVID-19 pandemic, with Pfizer/BioNTech (BNT162b2) being widely used.
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A large deletion in a non-coding regulatory region leads to NFKB1 haploinsufficiency in two adult siblings Clin. Immunol. (IF 8.6) Pub Date : 2024-02-27 Mathieu Fusaro, Cyrille Coustal, Laura Barnabei, Quentin Riller, Marion Heller, Duong Ho Nhat, Cécile Fourrage, Sophie Rivière, Frédéric Rieux-Laucat, Alexandre Thibault Jacques Maria, Capucine Picard
Mutations in NFkB pathway genes can cause inborn errors of immunity (IEI), with NFKB1 haploinsufficiency being a significant etiology for common variable immunodeficiency (CVID). Indeed, mutations in NFKB1 are found in 4 to 5% of in European and United States CVID cohorts, respectively; CVID representing almost ¼ of IEI patients in European countries registries. This case study presents a 49-year-old
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Rowell's syndrome with Condyloma acuminatum: A case report Clin. Immunol. (IF 8.6) Pub Date : 2024-02-22 Min Li, Ruiye Huang, Weiwei Wu, Yang Lu, Qiao Liu, Wen Li
Rowell's syndrome is an autoimmune disease characterized by lupus erythematosus, erythema multiforme skin lesions, and speckled antinuclear antibody. We report the case of a woman who presented with erythema multiforme with target-type skin lesions and vulvar vegetation who fulfilled the criteria for Rowell's syndrome and condyloma acuminatum. The simultaneous occurrence of both conditions has rarely
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Immmunometabolism of systemic lupus erythematosus Clin. Immunol. (IF 8.6) Pub Date : 2024-02-20 Marlene Marte Furment, Andras Perl
Systemic lupus erythematosus (SLE) is a potentially fatal chronic autoimmune disease which is underlain by complex dysfunction of the innate and adaptive immune systems. Although a series of well-defined genetic and environmental factors have been implicated in disease etiology, neither the development nor the persistence of SLE is well understood. Given that several disease susceptibility genes and
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Progranulin promotes regulatory T cells plasticity by mitochondrial metabolism through AMPK/PGC-1α pathway in ARDS Clin. Immunol. (IF 8.6) Pub Date : 2024-02-15 Yanqing Chen, Minkang Guo, Ke Xie, Ming Lei, Yusen Chai, Zhengtao Zhang, Zhenhua Deng, Qiaozhi Peng, Ju Cao, Shihui Lin, Fang Xu
As the aging population increases, the focus on elderly patients with acute respiratory distress syndrome (ARDS) is also increasing. In this article, we found progranulin (PGRN) differential expression in ARDS patients and healthy controls, even in young and old ARDS patients. Its expression strongly correlates with several cytokines in both young and elderly ARDS patients. PGRN has comparable therapeutic
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Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopenia Clin. Immunol. (IF 8.6) Pub Date : 2024-02-15 Roshini S. Abraham, Amrita Basu, Jennifer R. Heimall, Elizabeth Dunn, Alison Yip, Malika Kapadia, Neena Kapoor, Lisa Forbes Satter, Rebecca Buckley, Richard O'Reilly, Geoffrey D.E. Cuvelier, Sharat Chandra, Jeffrey Bednarski, Sonali Chaudhury, Theodore B. Moore, Hilary Haines, Blachy J. Dávila Saldaña, Deepakbabu Chellapandian, Ahmad Rayes, Karin Chen, Emi Caywood, Shanmuganathan Chandrakasan, Mark
Severe combined immunodeficiency (SCID) is characterized by a severe deficiency in T cell numbers. We analyzed data collected ( = 307) for PHA-based T cell proliferation from the PIDTC SCID protocol 6901, using either a radioactive or flow cytometry method. In comparing the two groups, a smaller number of the patients tested by flow cytometry had <10% of the lower limit of normal proliferation as compared
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Bruton's tyrosine kinase ablation inhibits B cell responses and antibody production for the prevention of chronic rejection in cardiac transplantation Clin. Immunol. (IF 8.6) Pub Date : 2024-02-15 Fei Han, Xiaoyi Shi, Tao Liao, Wei Zhang, Maolin Ma, Qianghua Leng, Weichen Jiang, Ning Na, Yun Miao, Zhengyu Huang
Chronic rejection is the primary cause of late allograft failure, however, the current treatments for chronic rejection have not yielded desirable therapeutic effects. B cell activation and donor-specific antibody (DSA) production are the primary factors leading to chronic rejection. Bruton's tyrosine kinase (BTK) plays a key role in the activation and differentiation of B cells and in antibody production
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Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome Clin. Immunol. (IF 8.6) Pub Date : 2024-02-13 Elizabeth E. Sloan, Katarina Kmetova, Somanathapura K. NaveenKumar, Lyndsay Kluge, Emily Chong, Claire K. Hoy, Srilakshmi Yalavarthi, Cyrus Sarosh, Jeanine Baisch, Lynnette Walters, Lorien Nassi, Julie Fuller, Jessica L. Turnier, Virginia Pascual, Tracey B. Wright, Jacqueline A. Madison, Jason S. Knight, Ayesha Zia, Yu Zuo
Our study aimed to evaluate the presence, clinical associations, and potential mechanistic roles of non-criteria antiphospholipid antibodies (aPL) and circulating calprotectin, a highly stable marker of neutrophil extracellular trap release (NETosis), in pediatric APS patients. We found that 79% of pediatric APS patients had at least one non-criteria aPL at moderate-to-high titer. Univariate logistic
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Z-nucleic acid sensor ZBP1 in sterile inflammation Clin. Immunol. (IF 8.6) Pub Date : 2024-02-10 Qixiang Song, Zehong Qi, Kangkai Wang, Nian Wang
-DNA binding protein 1 (ZBP1), a cytosolic nucleic acid sensor for -form nucleic acids (Z-NA), can detect both exogenous and endogenous nucleic acids. Upon sensing of self Z-NA or exposure to diverse noxious stimuli, ZBP1 regulates inflammation by activating nuclear factor kappa B and interferon regulating factor 3 signaling pathways. In addition, ZBP1 promotes the assembly of ZBP1 PANoptosome, which
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Determining reference ranges for lymphocyte proliferation responses to phytohemagglutinin and Bacillus Calmette–Guérin in Iranian children Clin. Immunol. (IF 8.6) Pub Date : 2024-02-10 Maryam Nourizadeh, Shokouh Azam Sarrafzadeh, Raheleh Shokouhi Shoormasti, Mohammad Reza Fazlollahi, Shiva Saghafi, Mohsen Badalzadeh, Milad Mirmoghtadaei, Zahra Pourpak
To establish reference ranges (RRs) for stimulation index of T cell proliferation triggered by phytohemagglutinin (PHA-SI) and Bacillus Calmette–Guérin (BCG-SI). This study investigated data from 359 healthy children and 35 patients with cellular immunodeficiency as positive controls (2010−2021). We applied a colorimetric-based method (BrdU) to measure proliferation and determine the RRs at the 2.5th
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Trained immunity-inducing vaccines: Harnessing innate memory for vaccine design and delivery Clin. Immunol. (IF 8.6) Pub Date : 2024-02-09 Ilayda Baydemir, Elisabeth A. Dulfer, Mihai G. Netea, Jorge Domínguez-Andrés
While the efficacy of many current vaccines is well-established, various factors can diminish their effectiveness, particularly in vulnerable groups. Amidst emerging pandemic threats, enhancing vaccine responses is critical. Our review synthesizes insights from immunology and epidemiology, focusing on the concept of trained immunity (TRIM) and the non-specific effects (NSEs) of vaccines that confer
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Involvement of expanded cytotoxic and proinflammatory CD28null T cells in primary Sjögren's syndrome Clin. Immunol. (IF 8.6) Pub Date : 2024-02-07 Chuiwen Deng, Anqi Wang, Wenli Li, Lidan Zhao, Jiaxin Zhou, Wen Zhang, Mengtao Li, Yunyun Fei
The absence of CD28 is a feature of antigen-experienced, highly differentiated and aged T cells. The pathogenicity of CD28 T cells remains elusive in primary Sjögren's syndrome (pSS). Therefore, this study was performed to explore the characteristics of CD28 T cells in both peripheral blood and minor salivary glands (MSGs) of pSS patients. pSS patients and paired healthy controls (HCs) were enrolled
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Age-specific Metabolomic profiles in children with food allergy Clin. Immunol. (IF 8.6) Pub Date : 2024-02-07 E. Crestani, M. Benamar, W. Phipatanakul, R. Rachid, T.A. Chatila
Food allergy (FA) in young children is often associated with eczema, frequently directed to egg/cow milk allergens and has a higher chance of resolution, while FA that persists in older children has less chance of resolution and is less clearly associated with atopy. Children with FA ( = 62) and healthy controls ( = 28) were categorized into “younger” (≤5 years) and “older” (>5 years). Mass spectrometry-based
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Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H Clin. Immunol. (IF 8.6) Pub Date : 2024-02-06 Danping Fan, Qishun Geng, Bailiang Wang, Xing Wang, Ya Xia, Liwen Yang, Qian Zhang, Tingting Deng, Yuan Xu, Hongyan Zhao, Bin Liu, Cheng Lu, Xiaofeng Gu, Cheng Xiao
Previous studies have shown that epigenetic factors are involved in the occurrence and development of rheumatoid arthritis (RA). However, the role of -methyladenosine (mA) methylation in RA has not been determined. The aim of this study was to investigate the role and regulatory mechanisms of hypoxia-induced expression of the mA demethylase alkB homolog 5 (ALKBH5) in RA fibroblast-like synoviocytes
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IKAROS gain of function disease: Allogeneic hematopoietic cell transplantation experience and expanded clinical phenotypes Clin. Immunol. (IF 8.6) Pub Date : 2024-02-05 Natchanun Klangkalya, Jennifer Stoddard, Julie Niemela, Jennifer Sponaugle, Irl Brian Greenwell, Erin Reigh, Hye Sun Kuehn, Jennifer A. Kanakry, Sergio D. Rosenzweig, Dimana Dimitrova
IKAROS, encoded by is a tumor suppressor and a key hematopoietic transcription factor responsible for lymphoid and myeloid differentiation. mutations result in inborn errors of immunity presenting with increased susceptibility to infections, immune dysregulation, and malignancies. In particular, patients carrying gain-of-function (GOF) mutations mostly exhibit symptoms of immune dysregulation and polyclonal
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IL-10-producing regulatory cells impact on celiac disease evolution Clin. Immunol. (IF 8.6) Pub Date : 2024-02-04 Laura Passerini, Giada Amodio, Virginia Bassi, Serena Vitale, Ilaria Mottola, Marina Di Stefano, Lorella Fanti, Paola Sgaramella, Chiara Ziparo, Silvia Furio, Renata Auricchio, Graziano Barera, Giovanni Di Nardo, Riccardo Troncone, Carmen Gianfrani, Silvia Gregori
Celiac Disease (CD) is a T-cell mediated disorder caused by immune response to gluten, although the mechanisms underlying CD progression are still elusive. We analyzed immune cell composition, plasma cytokines, and gliadin-specific T-cell responses in patients with positive serology and normal intestinal mucosa (potential-CD) or villous atrophy (acute-CD), and after gluten-free diet (GFD). We found:
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WITHDRAWN: Border-associated macrophages in the central nervous system Clin. Immunol. (IF 8.6) Pub Date : 2024-02-04 Rui Sun, Haowu Jiang
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
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Tumor cell-derived LC3B+extracellular vesicles mediate the crosstalk between tumor microenvironment and immunotherapy efficacy in hepatocellular carcinoma via the HSP90α-IL-6/IL-8 signaling axis Clin. Immunol. (IF 8.6) Pub Date : 2024-02-03 Yong-Qiang Chen, Zhong-Song Man, Lu Zheng, Yue Zhang, Cheng-Wen Zhao, Yu-Ting Ma, Juan Zhou, Peng Wang, Yang Yu, Feng Gu, Guo-Ping Niu
Inflammatory factors are being recognized as critical modulators of host antitumor immunity in liver cancer. We have previously shown that tumor cell-released LC3B positive extracellular vesicles (LC3B EVs) are responsible for malignant progression by dampening antitumor immunity. However, the relationship between LC3B EVs and inflammatory factors in the regulation of the liver cancer microenvironment
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METTL3/16-mediated m6A modification of ZNNT1 promotes hepatocellular carcinoma progression by activating ZNNT1/osteopontin/S100A9 positive feedback loop-mediated crosstalk between macrophages and tumour cells Clin. Immunol. (IF 8.6) Pub Date : 2024-02-03 Huamei Wei, Wenchuan Li, Meng Yang, Quan Fang, Jiahui Nian, Youguan Huang, Qing Wei, Zihua Huang, Guoman Liu, Zuoming Xu, Anbin Hu, Jian Pu
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Effect of allogeneic hematopoietic stem cell transplantation for chronic granulomatous disease in children: A multicentre, retrospective cohort study in China Clin. Immunol. (IF 8.6) Pub Date : 2024-02-02 Yingjian Si, Ying Dou, Xiaowen Zhai, Chen Zhou, Wei Lu, Yan Meng, Xiaowen Qian, Jing Chen, Ping Wang, Changying Luo, Jie Yu, Xiangfeng Tang
Chronic granulomatous disease (CGD) in children is a rare primary immunodeficiency disorder that can lead to life-threatening infections and inflammatory complications. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is increasingly being used to treat severe CGD in children. We conducted a multicenter retrospective analysis of children with CGD who were treated with allo-HSCT at four
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Epigenetic immune cell quantification for diagnostic evaluation and monitoring of patients with inborn errors of immunity and secondary immune deficiencies Clin. Immunol. (IF 8.6) Pub Date : 2024-02-02 Neftali J. Ramirez, Janika J. Schulze, Steffi Walter, Jeannette Werner, Pavla Mrovecova, Sven Olek, Christoph Sachsenmaier, Bodo Grimbacher, Ulrich Salzer
Early detection and monitoring of primary immunodeficiencies (PID) in humans require quantitative determination of immune cells from fresh blood analyzed by flow cytometry. However, epigenetic immune cell quantification allows analysis from fresh, frozen, or dried blood samples. We demonstrate the utility of epigenetic immune cell quantification for patients with PID. Epigenetic quantification of basic
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Comprehensive Analysis of Predictive Value and the potential therapeutic target of NLRP3 inflammasome in glioma based on tumor microenvironment Clin. Immunol. (IF 8.6) Pub Date : 2024-02-01 Bihan Li, Ying Liu, Dawei Chen, Shilong Sun
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CD36 regulates macrophage and endothelial cell activation and multinucleate giant cell formation in anti neutrophil cytoplasm antibody vasculitis Clin. Immunol. (IF 8.6) Pub Date : 2024-01-27 Xiang Zhang, Catherine King, Alexander Dowell, Paul Moss, Lorraine Harper, Dimitrios Chanouzas, Xiong-zhong Ruan, Alan David Salama
Objective To investigate CD36 in ANCA-associated vasculitis (AAV), a condition characterized by monocyte/macrophage activation and vascular damage. Methods CD36 expression was assessed in AAV patients and healthy controls (HC). The impact of palmitic acid (PA) stimulation on multinucleate giant cell (MNGC) formation, macrophage, and endothelial cell activation, with or without CD36 knockdown, was examined
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IKAROS expression drives the aberrant metabolic phenotype of macrophages in chronic HIV infection Clin. Immunol. (IF 8.6) Pub Date : 2024-01-28 Cecilia Vittori, Celeste Faia, Dorota Wyczechowska, Amber Trauth, Karlie Plaisance-Bonstaff, Mary Meyaski-Schluter, Krzysztof Reiss, Francesca Peruzzi
The increased risk for acquiring secondary illnesses in people living with HIV (PLWH) has been associated with immune dysfunction. We have previously found that circulating monocytes from PLWH display a trained phenotype. Here, we evaluated the metabolic profile of these cells and found increased mitochondrial respiration and glycolysis of monocyte-derived macrophages (MDMs) from PLWH. We additionally
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Revisiting prostaglandin E2: A promising therapeutic target for osteoarthritis Clin. Immunol. (IF 8.6) Pub Date : 2024-01-21 Dinglong Yang, Ke Xu, Xin Xu, Peng Xu
Osteoarthritis (OA) is a complex disease characterized by cartilage degeneration and persistent pain. Prostaglandin E2 (PGE2) plays a significant role in OA inflammation and pain. Recent studies have revealed the significant role of PGE2-mediated skeletal interoception in the progression of OA, providing new insights into the pathogenesis and treatment of OA. This aspect also deserves special attention
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