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MDSC expansion during HIV infection: regulators, ART and immune reconstitution Genes. Immun. (IF 5.0) Pub Date : 2024-04-11 Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani
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Comparative single-cell transcriptomic profile of hybrid immunity induced by adenovirus vector-based COVID-19 vaccines Genes. Immun. (IF 5.0) Pub Date : 2024-04-03 Melissa García-Vega, Hui Wan, Mónica Reséndiz-Sandoval, Diana Hinojosa-Trujillo, Olivia Valenzuela, Verónica Mata-Haro, Freddy Dehesa-Canseco, Mario Solís-Hernández, Harold Marcotte, Qiang Pan-Hammarström, Jesús Hernández
In this study, antibody response and a single-cell RNA-seq analysis were conducted on peripheral blood mononuclear cells from five different groups: naïve subjects vaccinated with AZD1222 (AZ) or Ad5-nCoV (Cso), individuals previously infected and later vaccinated (hybrid) with AZD1222 (AZ-hb) or Ad5-nCoV (Cso-hb), and those who were infected and had recovered from COVID-19 (Inf). The results showed
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Neu5Gc regulates decidual macrophages leading to abnormal embryo implantation Genes. Immun. (IF 5.0) Pub Date : 2024-03-18 Wu Yue, Zhou Huiling, Liu Yuxin, Wang Ling, Gao Feng, Liu Qicai
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Chemoimmunotherapy combinations: translating basic knowledge into clinical successes Genes. Immun. (IF 5.0) Pub Date : 2024-03-13 Lionel Apetoh
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Intratumoral NK cell delivery combined with neutralization of the NKG2A pathway as treatment for solid cancer Genes. Immun. (IF 5.0) Pub Date : 2024-03-09 Ignacio Melero, Carmen Molina, Cristina Eguizabal, Maite Alvarez
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Getting under the skin: resident memory CD8+ T cells have a second residence in the draining lymph node Genes. Immun. (IF 5.0) Pub Date : 2024-03-08 Teresa Neuwirth, Azuah L. Gonzalez, Emilie Fisher-Gupta, Georg Stary
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Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease Genes. Immun. (IF 5.0) Pub Date : 2024-02-23 Marisa Flook, Elena Rojano, Alvaro Gallego-Martinez, Alba Escalera-Balsera, Patricia Perez-Carpena, M. del Carmen Moleon, Rocio Gonzalez-Aguado, Victoria Rivero de Jesus, Emilio Domínguez-Durán, Lidia Frejo, Juan A. G. Ranea, Jose Antonio Lopez-Escamez
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Navigating the thymic landscape through development: from cellular atlas to tissue cartography Genes. Immun. (IF 5.0) Pub Date : 2024-02-10 Dörte Symmank, Felix Clemens Richter, André F. Rendeiro
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An immunogenomic exome landscape of triple positive primary antiphospholipid patients Genes. Immun. (IF 5.0) Pub Date : 2024-01-24 A. Guffroy, L. Jacquel, Y. Seeleuthner, N. Paul, V. Poindron, F. Maurier, V. Delannoy, A. C. Voegeli, P. Zhang, B. Nespola, A. Molitor, M. J. Apithy, P. Soulas-Sprauel, T. Martin, R. E. Voll, S. Bahram, V. Gies, J. L. Casanova, A. Cobat, B. Boisson, R. Carapito, A. S. Korganow
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BCL2 inhibition stimulates dendritic cell function for improved anticancer immunotherapy Genes. Immun. (IF 5.0) Pub Date : 2024-01-24 Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp
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Same name, different game?—How ontogeny shapes classical monocyte phenotypes Genes. Immun. (IF 5.0) Pub Date : 2024-01-20 Lisabeth Pimenov, Azuah Lucrecia Gonzalez, Amanda C. Doran, Sylvia Knapp
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Do inhibitory receptors need to be proximal to stimulatory receptors to function? Genes. Immun. (IF 5.0) Pub Date : 2024-01-12 Jonathan D. Worboys, Daniel M. Davis
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Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk Genes. Immun. (IF 5.0) Pub Date : 2023-12-23 Maxime Rotival, Lluis Quintana-Murci
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Uncovering intestinal macrophages through the integration of single-cell and spatial transcriptomics Genes. Immun. (IF 5.0) Pub Date : 2023-12-23 Alba Garrido-Trigo, Marisol Veny, Azucena Salas
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The genomics revolution comes to the immunopeptidome Genes. Immun. (IF 5.0) Pub Date : 2023-12-22 Peter M. Bruno
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Deciphering the host genetic factors conferring susceptibility to severe COVID-19 using exome sequencing Genes. Immun. (IF 5.0) Pub Date : 2023-12-20 Kubra Uslu, Firat Ozcelik, Gokmen Zararsiz, Vahap Eldem, Ahu Cephe, Izem Olcay Sahin, Recep Civan Yuksel, Hilal Sipahioglu, Zuhal Ozer Simsek, Osman Baspinar, Hilal Akalin, Yasin Simsek, Kursat Gundogan, Nuri Tutar, Aynur Karayol Akin, Yusuf Ozkul, Orhan Yildiz, Munis Dundar
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AHR and tryptophan metabolism: a collaborative dynamics of immune regulation Genes. Immun. (IF 5.0) Pub Date : 2023-12-16 Jingjing Zhu, Benoit J. Van den Eynde
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Orchestrating an immune response to cancer with cellular reprogramming Genes. Immun. (IF 5.0) Pub Date : 2023-12-15 Olga Zimmermannova, Alexandra Gabriela Ferreira, Carlos-Filipe Pereira
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From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6 Genes. Immun. (IF 5.0) Pub Date : 2023-12-11 Johannes C. Melms, Patricia Ho, Meri Rogava, Benjamin Izar
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Targeting CTLA-4: a possible solution for microsatellite-stable colorectal cancer Genes. Immun. (IF 5.0) Pub Date : 2023-12-08 François Ghiringhelli, Marion Thibaudin
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Serving up whatever you wish: CRISPR-base editing generates novel cancer-restricted antigens for immunotherapy Genes. Immun. (IF 5.0) Pub Date : 2023-12-11 Ute E. Burkhardt, Edward F. Fritsch
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Mapping the landscape of T cell-recognized neoantigens in cancer patients Genes. Immun. (IF 5.0) Pub Date : 2023-12-08 Wouter Scheper
Immunotherapies for cancer that seek to leverage the anti-tumor reactivity of T cells, such as immune checkpoint inhibition, have yielded remarkable clinical effects in a proportion of cancer patients. Evidence from work performed over the last 5–10 years suggests that the clinical efficacy of these therapies in many cases depends on the reactivity of patient T cells to so-called neoantigens—short
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To whom B cells toll extrafollicular responses Genes. Immun. (IF 5.0) Pub Date : 2023-12-08 Jonathan H. Lam, Nicole Baumgarth
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Interleukin-3 gets a fresh start in the brain Genes. Immun. (IF 5.0) Pub Date : 2023-12-08 Abi G. Yates, Annie Khamhoung, Cameron S. McAlpine
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RNA modifications-a regulatory dimension yet to be deciphered in immunity. Genes. Immun. (IF 5.0) Pub Date : 2023-11-20 Cuong Thi Pham,Laurie Rangan,Susan Schlenner
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Genetic variants of interferon-response factor 5 are associated with the incidence of chronic kidney disease: the D.E.S.I.R. study Genes. Immun. (IF 5.0) Pub Date : 2023-11-17 Frédéric Fumeron, Gilberto Velho, Fawaz Alzaid, Ray El Boustany, Claire Vandiedonck, Amélie Bonnefond, Philippe Froguel, Louis Potier, Michel Marre, Beverley Balkau, Ronan Roussel, Nicolas Venteclef
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Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2) Genes. Immun. (IF 5.0) Pub Date : 2023-11-04 Aroosha Raja, Jonas J. W. Kuiper
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Circulating biomarkers at diagnosis correlate with distant metastases of early luminal-like breast cancer Genes. Immun. (IF 5.0) Pub Date : 2023-09-27 Yentl Lambrechts, Abhishek D. Garg, Giuseppe Floris, Kevin Punie, Patrick Neven, Ines Nevelsteen, Jannes Govaerts, François Richard, Annouschka Laenen, Christine Desmedt, Hans Wildiers, Sigrid Hatse
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“IL-2 immunotherapy for targeting regulatory T cells in autoimmunity” Genes. Immun. (IF 5.0) Pub Date : 2023-09-23 Valentina Lykhopiy, Vanshika Malviya, Stephanie Humblet-Baron, Susan M. Schlenner
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Disentangling the complexity of psoriasis in the post-genome-wide association era Genes. Immun. (IF 5.0) Pub Date : 2023-09-16 Charalabos Antonatos, Katerina Grafanaki, Sophia Georgiou, Evangelos Evangelou, Yiannis Vasilopoulos
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Reverse translation: the key to increasing the clinical success of immunotherapy? Genes. Immun. (IF 5.0) Pub Date : 2023-09-11 Isaure Vanmeerbeek, Stefan Naulaerts, Abhishek D. Garg
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Hypertonic saline induces inflammation in human macrophages through the NLRP1 inflammasome Genes. Immun. (IF 5.0) Pub Date : 2023-08-12 Francesca Sposito, Sarah Northey, Amandine Charras, Paul S. McNamara, Christian M. Hedrich
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Research progress on the application of single-cell sequencing in autoimmune diseases Genes. Immun. (IF 5.0) Pub Date : 2023-08-07 Xueli Yang, Xianliang Hou, Junning Zhang, Zhenyu Liu, Guangyu Wang
Autoimmune diseases (AIDs) are caused by immune tolerance deficiency or abnormal immune regulation, leading to damage to host organs. The complicated pathogenesis and varied clinical symptoms of AIDs pose great challenges in diagnosing and monitoring this disease. Regrettably, the etiological factors and pathogenesis of AIDs are still not completely understood. It is noteworthy that the development
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Clinical, immunological and molecular findings of 8 patients with typical and atypical severe combined immunodeficiency: identification of 7 novel mutations by whole exome sequencing Genes. Immun. (IF 5.0) Pub Date : 2023-07-29 Zahra Alizadeh, Mohammad Reza Fazlollahi, Marzieh Mazinani, Mohsen Badalzadeh, Hanieh Heydarlou, Raphael Carapito, Anne Molitor, Andrés Caballero Garcia de Oteyza, Michele Proietti, Maryam Soleimani Bavani, Mansoureh Shariat, Morteza Fallahpour, Masoud Movahedi, Leila Moradi, Bodo Grimbacher, Seiamak Bahram, Zahra Pourpak
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Transmission disequilibrium analysis of whole genome data in childhood-onset systemic lupus erythematosus Genes. Immun. (IF 5.0) Pub Date : 2023-07-24 Kathleen M. Vazzana, Anthony M. Musolf, Joan E. Bailey-Wilson, Linda T. Hiraki, Earl D. Silverman, Christiaan Scott, Clifton L. Dalgard, Sarfaraz Hasni, Zuoming Deng, Mariana J. Kaplan, Laura B. Lewandowski
Childhood-onset systemic lupus erythematosus (cSLE) patients are unique, with hallmarks of Mendelian disorders (early-onset and severe disease) and thus are an ideal population for genetic investigation of SLE. In this study, we use the transmission disequilibrium test (TDT), a family-based genetic association analysis that employs robust methodology, to analyze whole genome sequencing data. We aim
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The dynamic interface of genetics and immunity: toward future horizons in health & disease Genes. Immun. (IF 5.0) Pub Date : 2023-07-18 Abhishek D. Garg
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Exploiting big data survival information to unify risk-stratification related, adaptive immune receptor parameters for multiple myeloma Genes. Immun. (IF 5.0) Pub Date : 2023-07-13 Hope J. Wolmarans, Vayda R. Barker, Andrea Chobrutskiy, Boris I. Chobrutskiy, Taha I. Huda, George Blanck
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Systems-level profiling of early peripheral host-response landscape variations across COVID-19 severity states in an Indian cohort Genes. Immun. (IF 5.0) Pub Date : 2023-07-12 Ushashi Banerjee, Sneha Chunchanur, Ambica R, Kithiganahalli Narayanaswamy Balaji, Amit Singh, Dipshikha Chakravortty, Nagasuma Chandra
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Integrated analyses reveal the prognostic, immunological features and mechanisms of cuproptosis critical mediator gene FDX1 in KIRC Genes. Immun. (IF 5.0) Pub Date : 2023-07-10 Yi Wang, Xinyu Zhang, Guihua Chen, Qianwei Xing, Bingye Zhu, Xiang Wang
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Potential diagnostic biomarkers: 6 cuproptosis- and ferroptosis-related genes linking immune infiltration in acute myocardial infarction Genes. Immun. (IF 5.0) Pub Date : 2023-07-08 Mengdan Miao, Shanhu Cao, Yifei Tian, Da Liu, Lixia Chen, Qiaoying Chai, Mei Wei, Shaoguang Sun, Le Wang, Shuanli Xin, Gang Liu, Mingqi Zheng
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αCGRP deficiency aggravates pulmonary fibrosis by activating the PPARγ signaling pathway Genes. Immun. (IF 5.0) Pub Date : 2023-05-25 Xiaoting Lv, Qingquan Chen, Zewei Zhang, Kaili Du, Yaping Huang, Xingzhe Li, Yiming Zeng
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IgE-binding monocytes upregulate the coagulation cascade in allergic horses Genes. Immun. (IF 5.0) Pub Date : 2023-05-16 Elisabeth M. Simonin, Bettina Wagner
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Identification of heat shock protein family A member 5 (HSPA5) targets involved in nonalcoholic fatty liver disease Genes. Immun. (IF 5.0) Pub Date : 2023-05-08 Aliya Rehati, Buzukela Abuduaini, Zhao Liang, Dong Chen, Fangping He
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Modulation of immune checkpoint regulators in interferon γ induced urothelial carcinoma and activated T-lymphocyte cells by cytostatics Genes. Immun. (IF 5.0) Pub Date : 2023-05-03 Jörg Hänze, Johannes Schulte-Herbrüggen, Rainer Hofmann, Axel Hegele
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Genetic epidemiology of resistance to M. tuberculosis Infection: importance of study design and recent findings Genes. Immun. (IF 5.0) Pub Date : 2023-04-22 Catherine M. Stein
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Long non-coding RNA maternally expressed gene 3, miR-125a-5p, CXCL13, and NF-kB in patients with immune thrombocytopenia Genes. Immun. (IF 5.0) Pub Date : 2023-04-12 Mervat Naguib, Shereen El Sawy, Laila Rashed, Maha AlHelf, Marwa Abdelgwad
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ACAT1-mediated METTL3 acetylation inhibits cell migration and invasion in triple negative breast cancer Genes. Immun. (IF 5.0) Pub Date : 2023-03-08 Gong Zhang, Ruyi Huang, Hui Zhao, Yuke Xia, Hui Huang, Mengjia Qian, Yuehe Fu, Yiyao Cui
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Tumor resident, TRA anti-viral CDR3 chemical sequence motifs are associated with a better breast cancer outcome Genes. Immun. (IF 5.0) Pub Date : 2023-02-18 Michael J. Diaz, Dorottya B. Kacsoh, Dhruv N. Patel, Michelle Yeagley, Monica Hsiang, George Blanck
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Pan-cancer transcriptomic analysis identified six classes of immunosenescence genes revealed molecular links between aging, immune system and cancer Genes. Immun. (IF 5.0) Pub Date : 2023-02-17 Xinyue Wang, Shuang Guo, Hanxiao Zhou, Yue Sun, Jing Gan, Yakun Zhang, Wen Zheng, Caiyu Zhang, Peng Wang, Hui Zhi, Yue Gao, Xiaofeng Chen, Shangwei Ning
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Slc11a1 gene polymorphism influences dextran sulfate sodium (DSS)-induced colitis in a murine model of acute inflammation Genes. Immun. (IF 5.0) Pub Date : 2023-02-15 Stephane Tereza Queiroz de Andrade, Tamíris Isabela Guidugli, Andrea Borrego, Bridilla Luiza Colhado Rodrigues, Natália Coelho Couto de Azevedo Fernandes, Juliana Mariotti Guerra, Jean Gabriel de Sousa, Nancy Starobinas, José Ricardo Jensen, Wafa Hanna Koury Cabrera, Marcelo De Franco, Olga Martinez Ibañez, Solange Massa, Orlando Garcia Ribeiro
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Role of DAMPs and cell death in autoimmune diseases: the example of multiple sclerosis Genes. Immun. (IF 5.0) Pub Date : 2023-02-07 Walter Gottlieb Land
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DNA methylation and transcriptome signatures of the PDCD1 gene in ankylosing spondylitis Genes. Immun. (IF 5.0) Pub Date : 2023-01-27 Ye Wu, Yuting Chen, Xiaoya Sun, Yujie Deng, Man Ni, Faming Pan
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Selective deficiency of UCP-1 and adropin may lead to different subtypes of anti-neutrophil cytoplasmic antibody-associated vasculitis Genes. Immun. (IF 5.0) Pub Date : 2023-01-20 Qingquan Chen, Youzhu Li, Xinxin Guo, Yuxin Liu, Yujia Guo, Xiaoting Lv, Yunfeng Lin, Qicai Liu
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Human lung carcinomas synthesize immunoregulatory glucocorticoids Genes. Immun. (IF 5.0) Pub Date : 2023-01-18 Verena M. Merk, Leonie Grob, Achim Fleischmann, Thomas Brunner
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Significance of HLA in the development of Graves’ orbitopathy Genes. Immun. (IF 5.0) Pub Date : 2023-01-13 Magdalena Stasiak, Katarzyna Zawadzka-Starczewska, Bogusław Tymoniuk, Bartłomiej Stasiak, Andrzej Lewiński
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Gene–environment interactions and their impact on human health Genes. Immun. (IF 5.0) Pub Date : 2022-12-30 Samuel J. Virolainen, Andrew VonHandorf, Kenyatta C. M. F. Viel, Matthew T. Weirauch, Leah C. Kottyan
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Characterization of the immunoglobulin lambda chain locus from diverse populations reveals extensive genetic variation Genes. Immun. (IF 5.0) Pub Date : 2022-12-21 William S. Gibson, Oscar L. Rodriguez, Kaitlyn Shields, Catherine A. Silver, Abdullah Dorgham, Matthew Emery, Gintaras Deikus, Robert Sebra, Evan E. Eichler, Ali Bashir, Melissa L. Smith, Corey T. Watson
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Immunodeficiency associated with a novel functionally defective variant of SLC19A1 benefits from folinic acid treatment Genes. Immun. (IF 5.0) Pub Date : 2022-12-15 Veysel Gök, Şerife Erdem, Yeşim Haliloğlu, Atıl Bişgin, Serkan Belkaya, Kemal Erdem Başaran, Mehmed Fatih Canatan, Alper Özcan, Ebru Yılmaz, Can Acıpayam, Musa Karakükcü, Halit Canatan, Hüseyin Per, Türkan Patıroğlu, Ahmet Eken, Ekrem Ünal
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Publisher Correction: Immunogenic cell death and its therapeutic or prognostic potential in high-grade glioma. Genes. Immun. (IF 5.0) Pub Date : 2022-12-01 Brecht Decraene,Yihan Yang,Frederik De Smet,Abhishek D Garg,Patrizia Agostinis,Steven De Vleeschouwer
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Lineage-specific protein repeat expansions and contractions reveal malleable regions of immune genes Genes. Immun. (IF 5.0) Pub Date : 2022-10-06 Lokdeep Teekas, Sandhya Sharma, Nagarjun Vijay