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Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy J. Autoimmun. (IF 12.8) Pub Date : 2024-04-24 Alina Huth, Ikram Ayoub, Lucie Barateau, Lisa Ann Gerdes, Dany Severac, Stefan Krebs, Helmut Blum, Hayrettin Tumani, Jürgen Haas, Brigitte Wildemann, Tania Kümpfel, Eduardo Beltrán, Roland S. Liblau, Yves Dauvilliers, Klaus Dornmair
Narcolepsy is a rare cause of hypersomnolence and may be associated or not with cataplexy, i.e. sudden muscle weakness. These forms are designated narcolepsy-type 1 (NT1) and -type 2 (NT2), respectively. Notable characteristics of narcolepsy are that most patients carry the allele and NT1-patients have strongly decreased levels of hypocretin-1 (synonym orexin-A) in the cerebrospinal fluid (CSF). The
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Blockade of neutrophil extracellular trap components ameliorates cholestatic liver disease in Mdr2 (Abcb4) knockout mice J. Autoimmun. (IF 12.8) Pub Date : 2024-04-22 Edith Hintermann, Camilla Tondello, Sina Fuchs, Monika Bayer, Josef M. Pfeilschifter, Richard Taubert, Martin Mollenhauer, Roland P.J. Oude Elferink, Michael P. Manns, Urs Christen
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Impaired IL-6-induced JAK-STAT signaling in CD4+ T cells associates with longer treatment duration in giant cell arteritis J. Autoimmun. (IF 12.8) Pub Date : 2024-04-22 Idil Esen, Maria Sandovici, Peter Heeringa, Annemieke M.H. Boots, Elisabeth Brouwer, Yannick van Sleen, Wayel Abdulahad
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PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis J. Autoimmun. (IF 12.8) Pub Date : 2024-04-21 Qishun Geng, Jiahe Xu, Xiaoxue Cao, Zhaoran Wang, Yi Jiao, Wenya Diao, Xing Wang, Zihan Wang, Mengxiao Zhang, Lu Zhao, Lei Yang, Tingting Deng, Bifa Fan, Yuan Xu, Lansi Jia, Cheng Xiao
Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by joint inflammation and bone damage, that not only restricts patient activity but also tends to be accompanied by a series of complications, seriously affecting patient prognosis. Peroxisome proliferator-activated receptor gamma (PPARG), a receptor that controls cellular metabolism, regulates the function of immune
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UHRF1P contributes to IL-17A-mediated systemic lupus erythematosus via UHRF1-MAP4K3 axis J. Autoimmun. (IF 12.8) Pub Date : 2024-04-20 Huai-Chia Chuang, Kuei-Yuan Lan, Pu-Ming Hsu, Ming-Han Chen, Yi-Ming Chen, Jeng-Hsien Yen, Ben-Yang Liao, Tse-Hua Tan
Inflammatory T cells contribute to the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Analysis of the T-cell transcriptomics data of two independent SLE patient cohorts by three machine learning models revealed the pseudogene UHRF1P as a novel SLE biomarker. The pseudogene-encoded UHRF1P protein was overexpressed in peripheral blood T cells of SLE patients. The UHRF1P
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Multi-omics study reveals different pathogenesis of the generation of skin lesions in SLE and IDLE patients J. Autoimmun. (IF 12.8) Pub Date : 2024-04-20 Qianwen Li, Chen Jia, Wenjing Pan, Hongmei Liu, Congli Tang, Daniel Weber, Kaili Chen, Hai Long, Miranda L. Byrne-Steele, Jian Han, Nongyue He, Rong Xiao, Ming Zhao, Nan Che, Qing Guo, Guangji Gui, Shanshan Li, Henan Si, Shuping Guo, Hongye Liu, Gang Wang, Guannan Zhu, Bin Yang, Yu Wang, Yan Ding, Xianxu Yang, Yoshimura Akihiko, Liwei Lu, Christopher Chang, Vera Chan, Chak-Sing Lau, Hai Qi, Wanli Liu
Lupus erythematosus (LE) is a heterogeneous, antibody-mediated autoimmune disease. Isolate discoid LE (IDLE) and systematic LE (SLE) are traditionally regarded as the two ends of the spectrum, ranging from skin-limited damage to life-threatening multi-organ involvement. Both belong to LE, but IDLE and SLE differ in appearance of skin lesions, autoantibody panels, pathological changes, treatments, and
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The CD318/CD6 axis limits type 1 diabetes islet autoantigen-specific human T cell activation J. Autoimmun. (IF 12.8) Pub Date : 2024-04-19 Jeong-su Do, David Arribas-Layton, Jemily Juan, Isaac Garcia, Sindhu Saraswathy, Meirigeng Qi, Enrique Montero, Helena Reijonen
CD6 is a glycoprotein expressed on CD4 and CD8 T cells involved in immunoregulation. CD318 has been identified as a CD6 ligand. The role of CD318 in T cell immunity is restricted as it has only been investigated in a few mice autoimmune models but not in human diseases. CD318 expression was thought to be limited to mesenchymal-epithelial cells and, therefore, contribute to CD6-mediated T cell activation
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Anti-U1RNP antibodies are associated with a distinct clinical phenotype and a worse survival in patients with systemic sclerosis J. Autoimmun. (IF 12.8) Pub Date : 2024-04-19 Kevin Chevalier, Guillaume Chassagnon, Sarah Leonard-Louis, Pascal Cohen, Bertrand Dunogue, Alexis Regent, Benjamin Thoreau, Luc Mouthon, Benjamin Chaigne
To clarify the impact of anti-U1RNP antibodies on the clinical features and prognosis of patients with SSc. We conducted a monocentric case-control, retrospective, longitudinal study. For each patient with SSc and anti-U1RNP antibodies (SSc-RNP), one patient with mixed connective tissue disease (MCTD) and 2 SSc patients without anti-U1RNP antibodies (SSc-RNP) were matched for age, sex, and date of
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Interleukin-15 is a hair follicle immune privilege guardian J. Autoimmun. (IF 12.8) Pub Date : 2024-04-05 Takahiro Suzuki, Jérémy Chéret, Fernanda S. Dinelli, Ali Rajabi-Estarabadi, Aysun Akhundlu, Dana-Lee Demetrius, Jennifer Gherardini, Aviad Keren, Matthew Harries, Jose Rodriguez-Feliz, Gorana Epstein-Kuka, Wendy Lee, Talveen Purba, Amos Gilhar, Ralf Paus
The autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth . We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ)
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Peripheral helper T cells in human diseases J. Autoimmun. (IF 12.8) Pub Date : 2024-04-04 Xueyang Zou, Feifei Huo, Lulu Sun, Jing Huang
Peripheral helper T cells (Tph) are a specialized subset of CD4 T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral blood, Tph cells can also be identified. The aberrant proliferation and functions of Tph cells are commonly found in the patients with disease. In this review, first we will
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Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients J. Autoimmun. (IF 12.8) Pub Date : 2024-03-29 Yoonho Lee, Jiwon Baek, Sojung Park, Yongjae Kim, Sung Wook Hwang, Jong Lyul Lee, Sang Hyoung Park, Jihun Kim, Suk-Kyun Yang, Buhm Han, Mi-Na Kweon, Kyuyoung Song, Yong Sik Yoon, Byong Duk Ye, Ho-Su Lee
Crohn's disease (CD) is a chronic inflammatory disorder affecting the bowel wall. Tissue-resident memory T (Trm) cells are implicated in CD, yet their characteristics remain unclear. We aimed to investigate the transcriptional profiles and functional characteristics of Trm cells in the small bowel of CD and their interactions with immune cells. Seven patients with CD and four with ulcerative colitis
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Balancing efficacy and safety of complement inhibitors J. Autoimmun. (IF 12.8) Pub Date : 2024-03-28 Kanako Watanabe-Kusunoki, Hans-Joachim Anders
Complement inhibitors have been approved for several immune-mediated diseases and they are considered the next paradigm-shifting approach in the treatment of glomerulonephritis. The hierarchical organization of the complement system offers numerous molecular targets for therapeutic intervention. However, complement is an integral element of host defense and therefore complement inhibition can be associated
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A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease J. Autoimmun. (IF 12.8) Pub Date : 2024-03-23 Anella Saviano, Anna Schettino, Nunzia Iaccarino, Adel Abo Mansour, Jenefa Begum, Noemi Marigliano, Federica Raucci, Francesca Romano, Gelsomina Riccardi, Emma Mitidieri, Roberta d'Emmanuele di Villa Bianca, Ivana Bello, Elisabetta Panza, Martina Smimmo, Valentina Vellecco, Peter Rimmer, Jonathan Cheesbrough, Zhaogong Zhi, Tariq H. Iqbal, Stefano Pieretti, Vincenzo Maria D'Amore, Luciana Marinelli
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Quantitative and structural changes of blood platelet cytoskeleton proteins in multiple sclerosis (MS) J. Autoimmun. (IF 12.8) Pub Date : 2024-03-22 Angela Dziedzic, Sylwia Michlewska, Piotr Jóźwiak, Janusz Dębski, Michał Seweryn Karbownik, Łukasz Łaczmański, Dorota Kujawa, Sława Glińska, Elżbieta Miller, Marta Niwald, Malgorzata Kloc, Łucja Balcerzak, Joanna Saluk
Epidemiological studies show that cardiovascular events related to platelet hyperactivity remain the leading causes of death among multiple sclerosis (MS) patients. Quantitative or structural changes of platelet cytoskeleton alter their morphology and function. Here, we demonstrated, for the first time, the structural changes in MS platelets that may be related to their hyperactivity. MS platelets
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Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice J. Autoimmun. (IF 12.8) Pub Date : 2024-03-16 Yaqi Wang, Shuang Wang, Wei Liu, Hanjiang Gu, Mai Luo, Tong Xiao, Mingzhu Zhou, Yutong Ran, Shengxiang Xiao, Yumin Xia, Huixia Wang
Peptide ALW (ALWPPNLHAWVP) targeting anti-dsDNA antibodies has shown promising therapeutic effects in alleviating lupus nephritis, but is potentially limited by poor stability and non-kidney targeting. We recently developed a D-form modified ALW, called D-ALW, which has the capacity to widely inhibit pathogenic polyclonal anti-dsDNA antibody reactions. Further modification of D-ALW using PEG-PLGA nanoparticles
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Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study J. Autoimmun. (IF 12.8) Pub Date : 2024-03-16 Zijian Kang, Xueliang Zhang, Yu Du, Sheng-Ming Dai
To provide a comprehensive analysis and modelling of the global epidemiology of psoriatic arthritis (PsA) in patients with psoriasis. We reviewed and analysed PsA epidemiology studies over the past 45 years. A Bayesian hierarchical linear mixed model was developed to provide comprehensive age- and sex-specific epidemiologic estimates in different countries and regions. Three hundred and sixty-three
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Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes J. Autoimmun. (IF 12.8) Pub Date : 2024-03-08 Ivan Garcia-Loza, David Perna-Barrull, Eva Aguilera, Lidia Almenara-Fuentes, Laia Gomez-Muñoz, Daniela Greco, Maria Vila, Miriam Salvado, Montserrat Mancera-Arteu, Michael W. Olszowy, Jordi Petriz, Marti Dalmases, Silvia Rodriguez-Vidal, Bruna Barneda-Zahonero, Marta Vives-Pi
Type 1 diabetes (T1D) results from a breakdown in immunological tolerance, with pivotal involvement of antigen-presenting cells. In this context, antigen-specific immunotherapies have been developed to arrest autoimmunity, such as phosphatidylserine (PS)-liposomes. However, the role of certain antigen-presenting cells in immunotherapy, particularly human macrophages (Mφ) in T1D remains elusive. The
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Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease J. Autoimmun. (IF 12.8) Pub Date : 2024-03-08 Dehao Zhu, Longfang Chen, Jianfen Meng, Mengyan Wang, Yuning Ma, Xia Chen, Yu Xiao, Da Yi, Hui Shi, Yue Sun, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Chengde Yang, Jialin Teng, Jinchao Jia, Qiongyi Hu
Macrophage activation syndrome (MAS) is a potentially fatal consequence of adult-onset Still's disease (AOSD), driven by a cytokine storm. Efficient early diagnosis of AOSD-associated MAS requires a sensitive and specific biomarker. In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD disease activity and served as a biomarker for AOSD-MAS. PTX3 levels
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Identifying the genetic association between systemic lupus erythematosus and the risk of autoimmune liver diseases J. Autoimmun. (IF 12.8) Pub Date : 2024-03-07 Wei Huang, Tianyu Jin, Wei Zheng, Qiaoqiao Yin, Qiqi Yan, Hongying Pan, Chengan Xu
Previous studies on the relationship between systemic lupus erythematosus (SLE) and autoimmune liver diseases (AILDs) are inconclusive. Therefore, we employed Mendelian randomization (MR) to explore the causal associations between SLE and AILDs. A two-sample MR analysis was performed using summary-level statistics sourced from genome-wide association study (GWAS) datasets. Inverse-variance weighting
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Ectopic CD4+ T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon-γ induced microglia activation J. Autoimmun. (IF 12.8) Pub Date : 2024-03-06 Keer Wang, Xiaoxiao Hou, Haimei Lu, Ning Han, Meijuan Xie, Anran Xi, Zhenghao Xu
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a disabling and potentially life-threatening complication of SLE. This study aims to investigate whether ectopic CD4 T cells in the choroid plexus mediate NPSLE in mice. Intracerebroventricular (ICV) injection of anti-CD4 antibody effectively depleted CP-resident CD4 T cells and alleviated NPSLE-like symptoms in MRL/lpr mice. Following ICV injection
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CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus J. Autoimmun. (IF 12.8) Pub Date : 2024-03-05 Thandiwe Chavula, Sarah To, Jennifer Smith, Mesias Pedroza, Jena Nimri, Sridevi Devaraj, Scott Wenderfer, Tiphanie P. Vogel, Sandeep K. Agarwal
Understanding the regulation of efferocytosis by myeloid phagocytes is important in identifying novel targets in systemic lupus erythematosus (SLE). Cadherin-11 (CDH11), a cell adhesion molecule, is implicated in inflammatory arthritis and fibrosis and recently been shown to regulate macrophage phagocytosis. The extent and mechanism of this regulation is unknown. Our objective was to examine the extent
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Extracellular microRNAs induce dendritic cell-dependent joint inflammation and potentiate osteoclast differentiation via TLR7/8 engagement J. Autoimmun. (IF 12.8) Pub Date : 2024-03-04 Carolina Gaudenzi, Tiziana Schioppa, Mauro Passari, Giovanni Zucchi, Laura Tiberio, Yasmin Vahidi, Sara Scutera, Tiziana Musso, Silvano Sozzani, Annalisa Del Prete, Valentina Salvi, Daniela Bosisio
Monocyte-derived dendritic cells (DCs) are key players in the induction of inflammation, autoreactive T cell activation and loss of tolerance in rheumatoid arthritis (RA), but the precise mechanisms underlying their activation remain elusive. Here, we hypothesized that extracellular microRNAs released in RA synovial fluids may represent a novel, physiological stimulus triggering unwanted immune response
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Application of laboratory models for sarcoidosis research J. Autoimmun. (IF 12.8) Pub Date : 2024-03-04 Maneesh Bhargava, Elliott D. Crouser
This manuscript will review the implications and applications of sarcoidosis models towards advancing our understanding of sarcoidosis disease mechanisms, identification of biomarkers, and preclinical testing of novel therapies. Emerging disease models and innovative research tools will also be considered.
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Impact of muscle biopsy on the clinical decision-making process in patients with suspected idiopathic inflammatory myopathy J. Autoimmun. (IF 12.8) Pub Date : 2024-03-01 Kastriot Kastrati, Nasim Nakhost Lotfi, Marwa G. Tawfik, Ellen Gelpi, Simon Hametner, Romana Höftberger, Fritz Zimprich, Hakan Cetin, Elisabeth Lindeck-Pozza, Peter Maximilian Heil, Hans P. Kiener, Leonhard X. Heinz, Daniel Mrak, Daniel Aletaha, Michael Bonelli, Helga Radner
The significance of muscle biopsy as a diagnostic tool in idiopathic inflammatory myopathies (IIM) remains elusive. We aimed to determine the diagnostic weight that has been given to muscle biopsy in patients with suspected IIM, particularly in terms of clinical diagnosis and therapeutic decisions. In this retrospective multicentric study, we analyzed muscle biopsy results of adult patients with suspected
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Autoimmune diseases and female-specific cancer risk: A systematic review and meta-analysis J. Autoimmun. (IF 12.8) Pub Date : 2024-02-29 Simone Fischer, Christa Meisinger, Dennis Freuer
Among the over 80 different autoimmune diseases, psoriasis (PsO), rheumatoid arthritis (RA), and ankylosing spondylitis (AS) are common representatives. Previous studies indicated a potential link with cancer risk, but suffered often from low statistical power. Thus, we aimed to synthesize the evidence and quantify the association to different female-specific cancer sites. The systematic review was
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Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice J. Autoimmun. (IF 12.8) Pub Date : 2024-02-29 Manna Lin, Liuting Huang, Junxia Huang, Jia Yu, Xue Yang, Ji Yang
Expansion of follicular helper T (Tfh) cells and abnormal glucose metabolism are present in patients with systemic lupus erythematosus (SLE). Pyruvate kinase M2 (PKM2) is one of the key glycolytic enzymes, and the underlying mechanism of PKM2-mediated Tfh cell glycolysis in SLE pathogenesis remains elusive. We analyzed the percentage of Tfh cells and glycolysis in CD4 T cells from SLE patients and
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miR-146a and miR-146b regulate the expression of ICAM-1 in giant cell arteritis J. Autoimmun. (IF 12.8) Pub Date : 2024-02-29 Martina Bonacini, Alessandro Rossi, Ilaria Ferrigno, Francesco Muratore, Luigi Boiardi, Alberto Cavazza, Alessandra Bisagni, Luca Cimino, Luca De Simone, Angelo Ghidini, Giuseppe Malchiodi, Marc Corbera-Bellalta, Maria Cinta Cid, Alessandro Zerbini, Carlo Salvarani, Stefania Croci
Giant cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries. MiRNAs are small, non-coding RNAs that inhibit gene expression at post-transcriptional level. Several miRNAs have been shown to be dysregulated in temporal artery biopsies (TABs) from GCA patients, but their role is unknown. The aims of the present work were: to gain insight into the link between inflammation and
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P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO) J. Autoimmun. (IF 12.8) Pub Date : 2024-02-23 Amandine Charras, Sigrun R. Hofmann, Allison Cox, Felix Schulze, Susanne Russ, Sarah Northey, Xuan Liu, Yongxiang Fang, Sam Haldenby, Hella Hartmann, Alexander G. Bassuk, Ana Carvalho, Francesca Sposito, Lev Grinstein, Angela Rösen-Wolff, Almut Meyer-Bahlburg, Michael W. Beresford, Elke Lainka, Dirk Foell, Helmut Wittkowski, Hermann J. Girschick, Henner Morbach, Steffen Uebe, Ulrike Hüffmeier, Polly
Chronic nonbacterial osteomyelitis (CNO), an autoinflammatory bone disease primarily affecting children, can cause pain, hyperostosis and fractures, affecting quality-of-life and psychomotor development. This study investigated CNO-associated variants in , encoding for the ATP-dependent -membrane K channel P2X7, and their effects on NLRP3 inflammasome assembly.
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mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses J. Autoimmun. (IF 12.8) Pub Date : 2024-02-21 Jet van den Dijssel, Mariël C. Duurland, Veronique AL. Konijn, Laura YL. Kummer, Ruth R. Hagen, Lisan H. Kuijper, Luuk Wieske, Koos PJ. van Dam, Eileen W. Stalman, Maurice Steenhuis, Dionne M. Geerdes, Juk Yee Mok, Angela HM. Kragten, Charlotte Menage, Lianne Koets, Barbera Veldhuisen, Niels JM. Verstegen, C Ellen van der Schoot, Wim JE. van Esch, Geert RAM. D'Haens, Mark Löwenberg, Adriaan G. Volkers
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Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype J. Autoimmun. (IF 12.8) Pub Date : 2024-02-19 Katharina Wørzner, Julie Zimmermann, Regitze Buhl, Anna Desoi, Dennis Christensen, Jes Dietrich, Nina Dieu Nhien Tran Nguyen, Thomas Lindenstrøm, Joshua S. Woodworth, Reham Sabah Alhakeem, Steven Yu, Niels Ødum, Rasmus Mortensen, Judith F. Ashouri, Gabriel K. Pedersen
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Risk factors for damage accrual in primary antiphospholipid syndrome: A retrospective single-center cohort study J. Autoimmun. (IF 12.8) Pub Date : 2024-02-17 Ariela Hoxha, Nicola Perin, Marco Lovisotto, Antonia Calligaro, Teresa Del Ross, Maria Favaro, Marta Tonello, Andrea Doria, Paolo Simioni
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LIGHT signaling through LTβR and HVEM in keratinocytes promotes psoriasis and atopic dermatitis-like skin inflammation J. Autoimmun. (IF 12.8) Pub Date : 2024-02-17 Rinkesh K. Gupta, Daniela Salgado Figueroa, Kai Fung, Haruka Miki, Jacqueline Miller, Ferhat Ay, Michael Croft
Psoriasis (PS) and atopic dermatitis (AD) are common skin inflammatory diseases characterized by hyper-responsive keratinocytes. Although, some cytokines have been suggested to be specific for each disease, other cytokines might be central to both diseases. Here, we show that Tumor necrosis factor superfamily member 14 (TNFSF14), known as LIGHT, is required for experimental PS, similar to its requirement
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The enigma of sclera-specific autoimmunity in scleritis J. Autoimmun. (IF 12.8) Pub Date : 2024-02-17 Daphne P.C. Vergouwen, Adriaan A. van Beek, Joeri de Hoog, Joke H. de Boer, Leonoor I. Los, Marlies Gijs, Roel J. Erckens, Rob M. Verdijk, Geert W. Haasnoot, Dave L. Roelen, Aniki Rothova, Johan Rönnelid, Josianne C. Ten Berge, Marco W.J. Schreurs
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T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities J. Autoimmun. (IF 12.8) Pub Date : 2024-02-15 Juexi Yang, Song Zhang, Qixuan Wu, Pu Chen, Yan Dai, Junhao Long, Yan Wu, Yun Lin
Psoriasis, a chronic inflammatory skin condition, is often accompanied by psychiatric comorbidities such as anxiety, depression, suicidal ideation, and other mental disorders. Psychological disorders may also play a role in the development and progression of psoriasis. The intricate interplay between the skin diseases and the psychiatric comorbidities is mediated by the ‘skin-brain axis’. Understanding
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Aberrant B cell receptor signaling in circulating naïve and IgA+ memory B cells from newly-diagnosed autoantibody-positive rheumatoid arthritis patients J. Autoimmun. (IF 12.8) Pub Date : 2024-02-13 Stefan F.H. Neys, Judith W. Heutz, Jennifer A.C. van Hulst, Madelief Vink, Ingrid M. Bergen, Pascal H.P. de Jong, Erik Lubberts, Rudi W. Hendriks, Odilia B.J. Corneth
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Age-related bone diseases: Role of inflammaging J. Autoimmun. (IF 12.8) Pub Date : 2024-02-09 Jiaming Bi, Caimei Zhang, Caihong Lu, Chuzi Mo, Jiawei Zeng, Mingyan Yao, Bo Jia, Zhongjun Liu, Peiyan Yuan, Shuaimei Xu
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The universal effects of low-dose interleukin-2 across 13 autoimmune diseases in a basket clinical trial J. Autoimmun. (IF 12.8) Pub Date : 2024-02-07 Roberta Lorenzon, Claire Ribet, Fabien Pitoiset, Selim Aractingi, Beatrice Banneville, Laurent Beaugerie, Francis Berenbaum, Patrice Cacoub, Julien Champey, Olivier Chazouilleres, Christophe Corpechot, Bruno Fautrel, Arsène Mekinian, Elodie Regnier, David Saadoun, Joe-Elie Salem, Jérémie Sellam, Philippe Seksik, Eric Vicaut, Michelle Rosenzwajg, David Klatzmann
A Tregs insufficiency is central to autoimmune and inflammatory diseases pathophysiology and low dose interleukin-2 (IL-2) can specifically activate Tregs. To assess IL-2 therapeutic potential and select diseases for further clinical development, we performed an open-label, phase 2a, disease-finding, “basket trial” involving patients with one of 13 different autoimmune diseases. 81 patients treated
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Phenotypes in antiphospholipid syndrome: A hierarchical cluster analysis based on two independent databases J. Autoimmun. (IF 12.8) Pub Date : 2024-02-07 Dov Taieb, Quentin Moyon, Raphael Lhote, Isabella Annesi-Maesano, Julien Haroche, Ricard Cervera, Zahir Amoura, Fleur Cohen Aubart
Antiphospholipid syndrome (APS) is a rare autoimmune disease characterized by thromboses at various sites and obstetric events associated with the persistent presence of antiphospholipid antibodies. The identification of clinical phenotypes in APS patients is a clinical need. In this study, we aimed to determine the clinical phenotypes of APS patients through an unsupervised analysis of two well-characterized
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IL-23 induces CLEC5A+ IL-17A+ neutrophils and elicit skin inflammation associated with psoriatic arthritis J. Autoimmun. (IF 12.8) Pub Date : 2024-02-01 Hiroki Furuya, Cuong Thach Nguyen, Trevor Chan, Alina I. Marusina, Alexander A. Merleev, Maria de la Luz Garcia-Hernandez, Shie-Liang Hsieh, George C. Tsokos, Christopher T. Ritchlin, Ilias Tagkopoulos, Emanual Maverakis, Iannis E. Adamopoulos
IL-23-activation of IL-17 producing T cells is involved in many rheumatic diseases. Herein, we investigate the role of IL-23 in the activation of myeloid cell subsets that contribute to skin inflammation in mice and man. IL-23 gene transfer in WT, IL-23R reporter mice and subsequent analysis with spectral cytometry show that IL-23 regulates early innate immune events by inducing the expansion of a
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CXCL12-CXCR4 mediates CD57+ CD8+ T cell responses in the progression of type 1 diabetes J. Autoimmun. (IF 12.8) Pub Date : 2024-02-01 Ting Zhong, Xinyu Li, Kang Lei, Rong Tang, Zhiguang Zhou, Bin Zhao, Xia Li
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Immunosuppression induces regression of fibrosis in primary biliary cholangitis with moderate-to-severe interface hepatitis J. Autoimmun. (IF 12.8) Pub Date : 2024-01-31 Rui Wang, Qiuxiang Lin, Zhonghua Lu, Haoyu Wen, Fangqin Hu, Jia You, Yonghong He, Yuan Fang, Zhaolian Bian, Qiuchen Hou, Zhaoxia Ju, Yanyan Wang, Min Lian, Xiao Xiao, Li Sheng, Canjie Guo, Jing Hua, Ruqi Tang, Zhengrui You, Xiaoyu Chen, M. Eric Gershwin, Zuxiong Huang, Qixia Wang, Qi Miao, Xiong Ma
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Older age of celiac disease diagnosis and risk of autoimmune disease: A nationwide matched case-control study J. Autoimmun. (IF 12.8) Pub Date : 2024-01-28 Shuai Yuan, Daniel Leffler, Benjamin Lebwohl, Peter H.R. Green, Susanna C. Larsson, Jonas Söderling, Jiangwei Sun, Jonas F. Ludvigsson
Celiac disease (CeD) has been linked to an increased risk of other autoimmune diseases, yet the impact of delayed CeD diagnosis on risk of developing additional autoimmune diseases remains uncertain. We investigated this through a nationwide matched case-control study. Using the ESPRESSO cohort with histophatology data from Sweden's 28 pathology departments, we assessed 46,575 biopsy-confirmed CeD
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A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile J. Autoimmun. (IF 12.8) Pub Date : 2024-01-13 Linnea Lindelöf, Solbritt Rantapää-Dahlqvist, Christian Lundtoft, Johanna K. Sandling, Dag Leonard, Ahmed Sayadi, Lars Rönnblom, Helena Enocsson, Christopher Sjöwall, Andreas Jönsen, Anders A. Bengtsson, Mun-Gwan Hong, Lina-Marcela Diaz-Gallo, Matteo Bianchi, Sergey V. Kozyrev, Kerstin Lindblad-Toh, the DISSECT consortium, the ImmunoArray consortium, Kristina Nilsson Ekdahl, Bo Nilsson, Iva Gunnarsson
The complement system plays a central role in the pathogenesis of Systemic Lupus Erythematosus (SLE), but most studies have focused on the classical pathway. Ficolin-3 is the main initiator of the lectin pathway of complement in humans, but its role in systemic autoimmune disease has not been conclusively determined. Here, we combined biochemical and genetic approaches to assess the contribution of
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Proximity extension assay proteomics and renal single cell transcriptomics uncover novel urinary biomarkers for active lupus nephritis J. Autoimmun. (IF 12.8) Pub Date : 2024-01-08 Yaxi Li, Chenling Tang, Kamala Vanarsa, Nga Thai, Jessica Castillo, Gabrielle Alexis Braza Lea, Kyung Hyun Lee, Soojin Kim, Claudia Pedroza, Tianfu Wu, Ramesh Saxena, Chi Chiu Mok, Chandra Mohan
To identify urinary biomarkers that can distinguish active renal involvement in Lupus Nephritis (LN), a severe manifestation of systemic lupus erythematosus (SLE). Urine from 117 subjects, comprised of inactive SLE, active non-renal lupus, active LN, and healthy controls, were subjected to Proximity Extension Assay (PEA) based comprehensive proteomics followed by ELISA validation in an independent
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Hoigné’s syndrome, an uncommon mimicker of anaphylaxis: Systematic literature review J. Autoimmun. (IF 12.8) Pub Date : 2024-01-08 Danilo Consolascio, Gabriel Bronz, Pietro F. Lardelli, Gregorio P. Milani, Sebastiano A.G. Lava, Benedetta Terziroli Beretta Piccoli, Mario G. Bianchetti, Marcel M. Bergmann, Mattia Rizzi
The term Hoigné’s syndrome denotes a mimicker of anaphylaxis, which occurs immediately after the parenteral administration of a drug and is likely caused by non-thrombotic pulmonary and systemic drug micro-embolization. It has so far been documented uniquely in case reports and small case series. Because this condition has never been systematically evaluated, we performed a structured literature review
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Single-cell sequencing of the retina shows that LDHA regulates pathogenesis of autoimmune uveitis J. Autoimmun. (IF 12.8) Pub Date : 2023-12-30 Xuening Peng, He Li, Lei Zhu, Sichen Zhao, Zhaohuai Li, Si Li, DongtingWu, Jialing Chen, Songguo Zheng, Wenru Su
Autoimmune uveitis (AU) is a severe disorder causing poor vision and blindness. However, the cellular dynamics and pathogenic mechanisms underlying retinal injury in uveitis remain unclear. In this study, single-cell RNA sequencing of the retina and cervical draining lymph nodes in experimental autoimmune uveitis mice was conducted to identify the cellular spatiotemporal dynamics and upregulation of
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Silencing of aryl hydrocarbon receptor repressor restrains Th17 cell immunity in autoimmune hepatitis J. Autoimmun. (IF 12.8) Pub Date : 2023-12-23 Li Gao, Wei Zhang, Lina Zhang, Barbora Gromova, Guanqing Chen, Eva Csizmadia, Cortney Cagle, Silvia Nastasio, Yun Ma, Alan Bonder, Vilas Patwardhan, Simon C. Robson, Sizun Jiang, Maria Serena Longhi
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Tofacitinib restores psoriatic arthritis fibroblast-like synoviocytes function via autophagy and mitochondrial quality control modulation J. Autoimmun. (IF 12.8) Pub Date : 2023-12-22 Ettore Silvagni, Sonia Missiroli, Simone Patergnani, Caterina Boncompagni, Clotilde D'Ugo, Carlo Garaffoni, Maria Sofia Ciliento, Giovanni Lanza, Massimo Bonora, Roberta Gafà, Mariasole Perrone, Alessandra Bortoluzzi, Carlotta Giorgi, Marcello Govoni, Carlo Alberto Scirè, Paolo Pinton
To evaluate the effect of tofacitinib on autophagy activity of psoriatic arthritis (PsA) fibroblast-like synoviocytes (FLS), and to confirm its activity on inflammatory and invasive properties of FLS and synovial cells, deepening the impact on mitochondrial function. FLS, peripheral blood mononuclear cells (PBMCs), and synovial cells from active PsA patients were cultured with tofacitinib 1 μM or vehicle
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Gene-expression profiling of laser-dissected islets and studies in deficient mice reveal chemokines as differential driving force of type 1 diabetes J. Autoimmun. (IF 12.8) Pub Date : 2023-12-22 Christine Bender, Peter Müller, Camilla Tondello, Jessica Horn, Martin Holdener, Stanley Lasch, Monika Bayer, Josef M. Pfeilschifter, Frank Tacke, Andreas Ludwig, Martin-Leo Hansmann, Claudia Döring, Edith Hintermann, Urs Christen
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High-content multimodal analysis supports the IL-7/IL-7 receptor axis as a relevant therapeutic target in primary Sjögren's syndrome J. Autoimmun. (IF 12.8) Pub Date : 2023-12-18 Emiko Desvaux, Patrice Hemon, Perrine Soret, Christelle Le Dantec, Loukas Chatzis, Divi Cornec, Valérie Devauchelle-Pensec
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Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown J. Autoimmun. (IF 12.8) Pub Date : 2023-12-09 Quentin Reuschlé, Laurien Van Heddegem, Victor Bosteels, Matthieu Moncan, Sabine Depauw, Nadège Wadier, Sandra Maréchal, Clint De Nolf, Virginia Delgado, Yosra Messai, Marie-Claude Stolzenberg, Aude Magérus, Angélique Werck, Jérôme Olagne, Quan Li, Guillaume Lefevre, Anne-Sophie Korganow, Frédéric Rieux-Laucat, Sophie Janssens, Pauline Soulas-Sprauel
Anti-nuclear antibodies are the hallmark of autoimmune diseases such as systemic lupus erythematosus (SLE) and scleroderma. However, the molecular mechanisms of B cell tolerance breakdown in these pathological contexts are poorly known. The study of rare familial forms of autoimmune diseases could therefore help to better describe common biological mechanisms leading to B cell tolerance breakdown.
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Associations between CD70 methylation of T cell DNA and age in adults with systemic lupus erythematosus and population controls: The Michigan Lupus Epidemiology & Surveillance (MILES) Program J. Autoimmun. (IF 12.8) Pub Date : 2023-12-08 Emily C. Somers, Jaclyn M. Goodrich, Lu Wang, Sioban D. Harlow, Wendy Marder, Afton L. Hassett, Suzanna M. Zick, W Joseph McCune, Caroline Gordon, Kamil E. Barbour, Charles G. Helmick, Faith M. Strickland
Environmental factors can influence epigenetic regulation, including DNA methylation, potentially contributing to systemic lupus erythematosus (SLE) development and progression. We compared methylation of the B cell costimulatory gene, in persons with lupus and controls, and characterized associations with age. In 297 adults with SLE and 92 controls from the Michigan Lupus Epidemiology and Surveillance
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High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DRβ1 chain J. Autoimmun. (IF 12.8) Pub Date : 2023-12-02 Nataliya Slater, Anuradha Sooda, Emily McLeish, Kelly Beer, Anna Brusch, Rakesh Shakya, Christine Bundell, Ian James, Abha Chopra, Frank L. Mastaglia, Merrilee Needham, Jerome D. Coudert
Inclusion body myositis (IBM) is a progressive inflammatory-degenerative muscle disease of older individuals, with some patients producing anti-cytosolic 5′-nucleotidase 1A (NT5C1A, aka cN1A) antibodies. Human Leukocyte Antigens (HLA) is the highest genetic risk factor for developing IBM. In this study, we aimed to further define the contribution of HLA alleles to IBM and the production of anti-cN1A
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Neointimal myofibroblasts contribute to maintaining Th1/Tc1 and Th17/Tc17 inflammation in giant cell arteritis J. Autoimmun. (IF 12.8) Pub Date : 2023-12-01 Hélène Greigert, André Ramon, Coraline Genet, Claudie Cladière, Claire Gerard, Marion Cuidad, Marc Corbera-Bellalta, Roser Alba-Rovira, Louis Arnould, Catherine Creuzot-Garcher, Laurent Martin, Georges Tarris, Thibault Ghesquière, Sethi Ouandji, Sylvain Audia, Maria C. Cid, Bernard Bonnotte, Maxime Samson
Vascular smooth muscle cells (VSMCs) have been shown to play a role in the pathogenesis of giant cell arteritis (GCA) through their capacity to produce chemokines recruiting T cells and monocytes in the arterial wall and their ability to migrate and proliferate in the neointima where they acquire a myofibroblast (MF) phenotype, leading to vascular stenosis. This study aimed to investigate if MFs could
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AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions J. Autoimmun. (IF 12.8) Pub Date : 2023-11-25 Keisuke Yasuda, Shieri Shimodan, Natsumi Maehara, Aika Hirota, Ruka Iijima, Akemi Nishijima, Haruka Mori, Ran Toyama, Atsumi Ito, Yuri Yoshikawa, Satoko Arai, Toru Miyazaki
The hallmark of autoimmune arthritis is the preceding autoantibody production and the following synovial inflammation with hyperplasia and tissue destruction of the joints. The joint inflammation is mediated not only by effector lymphocytes and auto-antibodies but also chronic activation of innate immunity, particularly promoted by the danger-associated molecular patterns (DAMPs). Here we show that
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2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis J. Autoimmun. (IF 12.8) Pub Date : 2023-11-14 Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Dörner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the joints and produces pain, swelling, and stiffness. It has a lifetime prevalence of up to 1% worldwide. An extract of Tripterygium wilfordii Hook F (TwHF), a member of the Celastraceae herbal family widely available in south China, has been used for treatment of RA since 1960s. The current consensus practice guidance (CPG) aims
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Single-cell transcriptomic profiling reveals a pathogenic role of cytotoxic CD4+ T cells in giant cell arteritis J. Autoimmun. (IF 12.8) Pub Date : 2023-11-11 Elio G. Carmona, José Luis Callejas-Rubio, Enrique Raya, Raquel Ríos-Fernández, Gonzalo Villanueva-Martín, María C. Cid, José Hernández-Rodríguez, Esteban Ballestar, Bernd Timmermann, Norberto Ortego-Centeno, Javier Martín, Ana Márquez
Giant cell arteritis (GCA) is a systemic vasculitis mediated by an aberrant immunological response against the blood vessel wall. Although the pathogenic mechanisms that drive GCA have not yet been elucidated, there is strong evidence that CD4 T cells are key drivers of the inflammatory process occurring in this vasculitis. The aim of this study was to further delineate the role of CD4 T cells in GCA
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Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences J. Autoimmun. (IF 12.8) Pub Date : 2023-11-11 Shane Kelly, Katherine JL. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
PR3 autoantibodies are essential to the diagnosis and monitoring of granulomatosus with polyangiitis, but to date no PR3 autoantibody sequences have been published. To identify and characterise PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. Peripheral blood mononuclear cells from seven patients with PR3 autoantibodies were stained with PR3. B cells that bound PR3
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Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19 J. Autoimmun. (IF 12.8) Pub Date : 2023-11-11 Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. McCoy, Irene M. Ong, Miriam A. Shelef
Rheumatoid factors (RFs), polyreactive antibodies canonically known to bind two conformational epitopes of IgG Fc, are a hallmark of rheumatoid arthritis but also can arise in other inflammatory conditions and infections. Also, infections may contribute to the development of rheumatoid arthritis and other autoimmune diseases. Recently, RFs only in rheumatoid arthritis were found to bind novel linear
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Risk factors for hypogammaglobulinemia and association with relapse and severe infections in ANCA-associated vasculitis: A cohort study J. Autoimmun. (IF 12.8) Pub Date : 2023-11-11 Johanne Liberatore, Yann Nguyen, Jérôme Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puéchal, Loïc Guillevin, Benjamin Terrier
B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) is a risk factor for hypogammaglobulinemia. Aggregating data on gammaglobulin levels kinetics during RTX and its association with the risk of relapse and severe infection is of interest. Gammaglobulin levels were collected before induction therapy and during RTX maintenance therapy. We used different definitions of gammaglobulin