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The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-27 Lea Gessler, Danyil Huraskin, Nane Eiber, Said Hashemolhosseini
Here, we investigated the role of the canonical Wnt signaling pathway transcriptional regulators at the neuromuscular junction. Upon applying a denervation paradigm, the transcription levels of Ctnnb1, Tcf7l1, Tle1, Tle2, Tle3, and Tle4 were significantly downregulated. A significant decrease in canonical Wnt signaling activity was observed using the denervation paradigm in Axin2-lacZ reporter mice
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Acupuncture for radicular pain: a review of analgesic mechanism Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-26 Hong-Lin Li, Yi Zhang, Jian-Wei Zhou
Radicular pain, a common and complex form of neuropathic pain, presents significant challenges in treatment. Acupuncture, a therapy originating from ancient traditional Chinese medicine and widely utilized for various pain types, including radicular pain, has shown promising outcomes in the management of lumbar radicular pain, cervical radicular pain, and radicular pain due to spinal stenosis. Despite
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Generation of contractile forces by three-dimensional bundled axonal tracts in micro-tissue engineered neural networks Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-25 Dimple Chouhan, Wisberty J. Gordián Vélez, Laura A. Struzyna, Dayo O. Adewole, Erin R. Cullen, Justin C. Burrell, John C. O’Donnell, D. Kacy Cullen
Axonal extension and retraction are ongoing processes that occur throughout all developmental stages of an organism. The ability of axons to produce mechanical forces internally and respond to externally generated forces is crucial for nervous system development, maintenance, and plasticity. Such axonal mechanobiological phenomena have typically been evaluated in vitro at a single-cell level, but these
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Oligodendrocytes in amyotrophic lateral sclerosis and frontotemporal dementia: the new players on stage Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-22 Marguerite Jamet, Luc Dupuis, Jose-Luis Gonzalez De Aguilar
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal adult-onset neurodegenerative disorders that share clinical, neuropathological and genetic features, which forms part of a multi-system disease spectrum. The pathological process leading to ALS and FTD is the result of the combination of multiple mechanisms that operate within specific populations of neurons and glial cells
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Early establishment of chloride homeostasis in CRH neurons is altered by prenatal stress leading to fetal HPA axis dysregulation Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-21 Miho Watanabe, Adya Saran Sinha, Yohei Shinmyo, Atsuo Fukuda
Corticotropin-releasing hormone (CRH) neurons play an important role in the regulation of neuroendocrine responses to stress. The excitability of CRH neurons is regulated by inhibitory GABAergic inputs. However, it is unclear when GABAergic regulation of CRH neurons is established during fetal brain development. Furthermore, the exact progression of the developmental shift of GABA action from depolarization
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Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-20 Nicolas Chofflet, Yusuke Naito, Anthony John Pastore, Nirmala Padmanabhan, Phuong Trang Nguyen, Christian Poitras, Benjamin Feller, Nayoung Yi, Jeremie Van Prooijen, Husam Khaled, Benoit Coulombe, Steven J. Clapcote, Steve Bourgault, Tabrez J. Siddiqui, Gabby Rudenko, Hideto Takahashi
The prevailing model behind synapse development and specificity is that a multitude of adhesion molecules engage in transsynaptic interactions to induce pre- and postsynaptic assembly. How these extracellular interactions translate into intracellular signal transduction for synaptic assembly remains unclear. Here, we focus on a synapse organizing complex formed by immunoglobulin superfamily member
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APOE3 Christchurch modulates β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer’s cases Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-20 Paula Perez-Corredor, Timothy E. Vanderleest, Guido N. Vacano, Justin S. Sanchez, Nelson D. Villalba-Moreno, Claudia Marino, Susanne Krasemann, Miguel A. Mendivil-Perez, David Aguillón, Marlene Jiménez-Del-Río, Ana Baena, Diego Sepulveda-Falla, Francisco Lopera, Yakeel T. Quiroz, Joseph F. Arboleda-Velasquez, Randall C. Mazzarino
A patient with the PSEN1 E280A mutation and homozygous for APOE3 Christchurch (APOE3Ch) displayed extreme resistance to Alzheimer’s disease (AD) cognitive decline and tauopathy, despite having a high amyloid burden. To further investigate the differences in biological processes attributed to APOE3Ch, we generated induced pluripotent stem (iPS) cell-derived cerebral organoids from this resistant case
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Cuproptosis in stroke: focusing on pathogenesis and treatment Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-19 Liwei Xing, Zhifeng Wang, Zhihui Hao, Pan Pan, Aiming Yang, Jian Wang
Annually, more than 15 million people worldwide suffer from stroke, a condition linked to high mortality and disability rates. This disease significantly affects daily life, impairing everyday functioning, executive function, and cognition. Moreover, stroke severely restricts patients’ ability to perform daily activities, diminishing their overall quality of life. Recent scientific studies have identified
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Knockdown of INPP5K compromises the differentiation of N2A cells Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-15 Annamaria Manzolillo, Lennart Gresing, Christian A. Hübner, Patricia Franzka
Inositol polyphosphate 5-phosphatase K (INPP5K), also known as SKIP (skeletal muscle and kidney-enriched inositol phosphatase), is a cytoplasmic enzyme with 5-phosphatase activity toward phosphoinositides (PIs). Mutations in INPP5K are associated with autosomal recessive congenital muscular dystrophy with cataracts and intellectual disability (MDCCAID). Notably, muscular dystrophy is characterized
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Correlational patterns of neuronal activation and epigenetic marks in the basolateral amygdala and piriform cortex following olfactory threat conditioning and extinction in rats Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-14 Tian Qin, Yue Xia, Negar Nazari, Tayebeh Sepahvand, Qi Yuan
IntroductionCumulative evidence suggests that sensory cortices interact with the basolateral amygdala (BLA) defense circuitry to mediate threat conditioning, memory retrieval, and extinction learning. The olfactory piriform cortex (PC) has been posited as a critical site for olfactory associative memory. Recently, we have shown that N-methyl-D-aspartate receptor (NMDAR)-dependent plasticity in the
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Pediatric CNS tumors and 2021 WHO classification: what do oncologists need from pathologists? Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-13 Antonio d’Amati, Lavinia Bargiacchi, Sabrina Rossi, Andrea Carai, Luca Bertero, Valeria Barresi, Maria Elena Errico, Anna Maria Buccoliero, Sofia Asioli, Gianluca Marucci, Giada Del Baldo, Angela Mastronuzzi, Evelina Miele, Federica D’Antonio, Marco Gessi, Manila Antonelli, Francesca Gianno
The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, established new approaches to both CNS tumor nomenclature and grading, emphasizing the importance of integrated diagnoses and layered reports. This edition increased the role of molecular diagnostics in CNS tumor classification while still relying on other established approaches such as histology
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The altered TBI fecal microbiome is stable and functionally distinct Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-13 Richard B. Pyles, Aaron L. Miller, Randall J. Urban, Melinda Sheffield-Moore, Traver J. Wright, Carrie A. Maxwell, Kathleen M. Randolph, Christopher P. Danesi, Kristen A. McGovern, Jayson Vargas, Peyton Armstrong, Lisa Kreber, Giuliana Cumpa, Kevin Randall, Melissa Morrison, Brent E. Masel
IntroductionPatients who suffer a traumatic brain injury (TBI) often experience chronic and sometimes debilitating sequelae. Recent reports have illustrated both acute and long-term dysbiosis of the gastrointestinal microbiome with significant alterations in composition and predicted functional consequences.MethodsWorking with participants from past research, metagenomic stability of the TBI- associated
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Diving into the zebrafish brain: exploring neuroscience frontiers with genetic tools, imaging techniques, and behavioral insights Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-12 O. Doszyn, T. Dulski, J. Zmorzynska
The zebrafish (Danio rerio) is increasingly used in neuroscience research. Zebrafish are relatively easy to maintain, and their high fecundity makes them suitable for high-throughput experiments. Their small, transparent embryos and larvae allow for easy microscopic imaging of the developing brain. Zebrafish also share a high degree of genetic similarity with humans, and are amenable to genetic manipulation
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A recognition of exosomes as regulators of epigenetic mechanisms in central nervous system diseases Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-11 Shunxin Hu, Lei Feng, Zhonghong Yang, Xuechen Fan, Haozheng Gao, Tiancai Yang
Exosomes, vesicular structures originating from cells, participate in the conveyance of proteins and nucleic acids. Presently, the centrality of epigenetic modifications in neurological disorders is widely acknowledged. Exosomes exert influence over various epigenetic phenomena, thereby modulating post-transcriptional regulatory processes contingent upon their constituent makeup. Consequently, the
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Activation of nucleus accumbens projections to the ventral tegmental area alters molecular signaling and neurotransmission in the reward system Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-11 Alaa Khayat, Rami Yaka
The nucleus accumbens (NAc) and the ventral tegmental area (VTA) are integral brain regions involved in reward processing and motivation, including responses to drugs of abuse. Previously, we have demonstrated that activation of NAc-VTA afferents during the acquisition of cocaine conditioned place preference (CPP) reduces the rewarding properties of cocaine and diminished the activity of VTA dopamine
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Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-07 Daisuke Tsuboi, Taku Nagai, Junichiro Yoshimoto, Kozo Kaibuchi
The unraveling of the regulatory mechanisms that govern neuronal excitability is a major challenge for neuroscientists worldwide. Neurotransmitters play a critical role in maintaining the balance between excitatory and inhibitory activity in the brain. The balance controls cognitive functions and emotional responses. Glutamate and γ-aminobutyric acid (GABA) are the primary excitatory and inhibitory
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Correlation of telomere length in brain tissue with peripheral tissues in living human subjects Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-07 Annemarie J. Carver, Benjamin Hing, Benjamin A. Elser, Stephanie J. Lussier, Takehiko Yamanashi, Matthew A. Howard, Hiroto Kawasaki, Gen Shinozaki, Hanna E. Stevens
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates with that in brain is not known. Saliva, buccal, blood, and brain samples were collected at time points before, during, and after subjects undergoing
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Post-translational modifications of beta-amyloid alter its transport in the blood-brain barrier in vitro model Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-07 Kseniya B. Varshavskaya, Irina Yu Petrushanko, Vladimir A. Mitkevich, Evgeny P. Barykin, Alexander A. Makarov
One of the hallmarks of Alzheimer's disease (AD) is the accumulation of beta-amyloid peptide (Aβ) leading to formation of soluble neurotoxic Aβ oligomers and insoluble amyloid plaques in various parts of the brain. Aβ undergoes post-translational modifications that alter its pathogenic properties. Aβ is produced not only in brain, but also in the peripheral tissues. Such Aβ, including its post-translationally
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Non-canonical retinoid signaling in neural development, regeneration and synaptic function Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-06 Alicia Piazza, Robert Carlone, Gaynor E. Spencer
Canonical retinoid signaling via nuclear receptors and gene regulation is critical for the initiation of developmental processes such as cellular differentiation, patterning and neurite outgrowth, but also mediates nerve regeneration and synaptic functions in adult nervous systems. In addition to canonical transcriptional regulation, retinoids also exert rapid effects, and there are now multiple lines
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New implications for prion diseases therapy and prophylaxis Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-04 Fangzhou Liu, Wenqi Lü, Ling Liu
Prion diseases are rare, fatal, progressive neurodegenerative disorders that affect both animal and human. Human prion diseases mainly present as Creutzfeldt-Jakob disease (CJD). However, there are no curable therapies, and animal prion diseases may negatively affect the ecosystem and human society. Over the past five decades, scientists are devoting to finding available therapeutic or prophylactic
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Invertebrate genetic models of amyotrophic lateral sclerosis Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-04 LiJun Zhou, RenShi Xu
Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by the progressive death of motor neurons in the cerebral cortex, brain stem, and spinal cord. The exact mechanisms underlying the pathogenesis of ALS remain unclear. The current consensus regarding the pathogenesis of ALS suggests that the interaction between genetic susceptibility and harmful environmental
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Human mutations in SLITRK3 implicated in GABAergic synapse development in mice Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-03-01 Stephanie Efthymiou, Wenyan Han, Muhammad Ilyas, Jun Li, Yichao Yu, Marcello Scala, Nancy T. Malintan, Muhammad Ilyas, Nikoleta Vavouraki, Kshitij Mankad, Reza Maroofian, Clarissa Rocca, Vincenzo Salpietro, Shenela Lakhani, Eric J. Mallack, Timothy Blake Palculict, Hong Li, Guojun Zhang, Faisal Zafar, Nuzhat Rana, Noriko Takashima, Hayato Matsunaga, Claudia Manzoni, Pasquale Striano, Mark F. Lythgoe
This study reports on biallelic homozygous and monoallelic de novo variants in SLITRK3 in three unrelated families presenting with epileptic encephalopathy associated with a broad neurological involvement characterized by microcephaly, intellectual disability, seizures, and global developmental delay. SLITRK3 encodes for a transmembrane protein that is involved in controlling neurite outgrowth and
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A critical evaluation of “leakage” at the cochlear blood-stria-barrier and its functional significance Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-29 Kevin K. Ohlemiller, Noël Dwyer, Veronica Henson, Kaela Fasman, Keiko Hirose
The blood-labyrinth-barrier (BLB) is a semipermeable boundary between the vasculature and three separate fluid spaces of the inner ear, the perilymph, the endolymph and the intrastrial space. An important component of the BLB is the blood-stria-barrier, which shepherds the passage of ions and metabolites from strial capillaries into the intrastrial space. Some investigators have reported increased
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Genetic loss of the dopamine transporter significantly impacts behavioral and molecular responses to sub-chronic stress in mice Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-29 Avelina Petri, Abigail Sullivan, Kristen Allen, Benjamin D. Sachs
Dopaminergic neurotransmission has emerged as a critical determinant of stress susceptibility and resilience. Although the dopamine transporter (DAT) is known to play a key role in maintaining dopamine (DA) homeostasis, its importance for the regulation of stress susceptibility remains largely unknown. Indeed, while numerous studies have examined the neurochemical and behavioral consequences of genetic
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Brain, behavior, and physiological changes associated with predator stress–An animal model for trauma exposure in adult and neonatal rats Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-29 Stacey L. Kigar, Amelia Cuarenta, Carla L. Zuniga, Liza Chang, Anthony P. Auger, Vaishali P. Bakshi
The use of predators and predator odor as stressors is an important and ecologically relevant model for studying the impact of behavioral responses to threat. Here we summarize neural substrates and behavioral changes in rats resulting from predator exposure. We briefly define the impact predator exposure has on neural targets throughout development (neonatal, juvenile, and adulthood). These findings
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Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-28 Kofi Frimpong-Manson, Yuma T. Ortiz, Lance R. McMahon, Jenny L. Wilkerson
The individual and global burden of migraine is of such significance that there are accelerated efforts to develop new therapies. New migraine therapeutics are needed to address the current deficiencies that exist in the efficacy and adherence rate of approved anti-migraine medications. The recent discovery of the calcitonin gene related peptide as an add-on to the role of serotonin has markedly increased
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Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-28 Uwe Thorsten Lux, Jutta Meyer, Olaf Jahn, Adam Davison, Norbert Babai, Andreas Gießl, Anna Wartenberg, Heinrich Sticht, Nils Brose, Kerstin Reim, Johann Helmut Brandstätter
Adaptation of photoreceptor sensitivity to varying light intensities is a fundamental requirement for retinal function and vision. Adaptive mechanisms in signal transduction are well described, but little is known about the mechanisms that adapt the photoreceptor synapse to changing light intensities. The SNARE complex regulators Complexin 3 and Complexin 4 have been proposed to be involved in synaptic
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Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-28 Paul Jakob Habakuk Hain, Tobias Moser
IntroductionRecently developed fluorescent neurotransmitter indicators have enabled direct measurements of neurotransmitter in the synaptic cleft. Precise optical measurements of neurotransmitter release may be used to make inferences about presynaptic function independent of electrophysiological measurements.MethodsHere, we express iGluSnFR, a genetically encoded glutamate reporter in mouse spiral
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Non-severe thermal burn injuries induce long-lasting downregulation of gene expression in cortical excitatory neurons and microglia Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-27 Rebecca C. S. Ong, Jamie L. Beros, Kathy Fuller, Fiona M. Wood, Phillip E. Melton, Jennifer Rodger, Mark W. Fear, Lucy Barrett, Andrew W. Stevenson, Alexander D. Tang
Burn injuries are devastating traumas, often leading to life-long consequences that extend beyond the observable burn scar. In the context of the nervous system, burn injury patients commonly develop chronic neurological disorders and have been suggested to have impaired motor cortex function, but the long-lasting impact on neurons and glia in the brain is unknown. Using a mouse model of non-severe
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LRRC25 expression during physiological aging and in mouse models of Alzheimer’s disease and iPSC-derived neurons Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-26 Dinesh Devadoss, Juliet Akkaoui, Madhavan Nair, Madepalli K. Lakshmana
The leucine-rich repeat-containing protein 25 (LRRC25) is relatively a novel protein with no information on its role in neuronal or brain function. A recent study suggested LRRC25 is a potential risk factor for Alzheimer’s disease (AD). As a first step to understanding LRRC25’s role in the brain and AD, we found LRRC25 is expressed in both cell membranes and cytoplasm in a punctuate appearance in astrocytes
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Interactions between Ras and Rap signaling pathways during neurodevelopment in health and disease Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-23 Salvatore J. Cherra, Reagan Lamb
The Ras family of small GTPases coordinates tissue development by modulating cell proliferation, cell-cell adhesion, and cellular morphology. Perturbations of any of these key steps alter nervous system development and are associated with neurological disorders. While the underlying causes are not known, genetic mutations in Ras and Rap GTPase signaling pathways have been identified in numerous neurodevelopmental
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Acetylome analyses provide novel insights into the effects of chronic intermittent hypoxia on hippocampus-dependent cognitive impairment Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-22 Fan Liu, Weiheng Yan, Chen Chen, Yubing Zeng, Yaru Kong, Xuejia He, Pei Pei, Shan Wang, Ting Zhang
IntroductionChronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechanisms. Protein acetylation, a frequently occurring modification, plays crucial roles in synaptic plasticity and cognitive processes. However, the global protein acetylation induced by CIH in the hippocampus and its specific effects on hippocampal function and behavior remain poorly
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Chemical LTP induces confinement of BDNF mRNA under dendritic spines and BDNF protein accumulation inside the spines Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-21 Giorgia Bimbi, Enrico Tongiorgi
The neurotrophin brain-derived neurotrophic factor (BDNF) plays a key role in neuronal development and synaptic plasticity. The discovery that BDNF mRNA can be transported in neuronal dendrites in an activity-dependent manner has suggested that its local translation may support synapse maturation and plasticity. However, a clear demonstration that BDNF mRNA is locally transported and translated at
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Machine learning-based evaluation of spontaneous pain and analgesics from cellular calcium signals in the mouse primary somatosensory cortex using explainable features Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-21 Myeong Seong Bak, Haney Park, Heera Yoon, Geehoon Chung, Hyunjin Shin, Soonho Shin, Tai Wan Kim, Kyungjoon Lee, U. Valentin Nägerl, Sang Jeong Kim, Sun Kwang Kim
IntroductionPain that arises spontaneously is considered more clinically relevant than pain evoked by external stimuli. However, measuring spontaneous pain in animal models in preclinical studies is challenging due to methodological limitations. To address this issue, recently we developed a deep learning (DL) model to assess spontaneous pain using cellular calcium signals of the primary somatosensory
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Ototoxicity of polystyrene nanoplastics in mice, HEI-OC1 cells and zebrafish Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-19 Yuancheng Wu, Lianzhen Li, Lihuan Tang, Willie Peijnenburg, Huangruici Zhang, Daoli Xie, Ruishuang Geng, Tihua Zheng, Liyan Bi, Xiaodan Wei, Han-jung Chae, Lan Wang, Li Zhao, Bo Li, Qingyin Zheng
Polystyrene nanoplastics are a novel class of pollutants. They are easily absorbed by living organisms, and their potential toxicity has raised concerns. However, the impact of polystyrene nanoplastics on auditory organs remains unknown. Here, our results showed that polystyrene nanoplastics entered the cochlea of mice, HEI-OC1 cells, and lateral line hair cells of zebrafish, causing cellular injury
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Molecular diversity and functional dynamics in the central amygdala Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-14 Li-Feng Yeh, Shuzhen Zuo, Pin-Wu Liu
The central amygdala (CeA) is crucial in integrating sensory and associative information to mediate adaptive responses to emotional stimuli. Recent advances in genetic techniques like optogenetics and chemogenetics have deepened our understanding of distinct neuronal populations within the CeA, particularly those involved in fear learning and memory consolidation. However, challenges remain due to
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Consequences of GMPPB deficiency for neuromuscular development and maintenance Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-14 Mona K. Schurig, Obinna Umeh, Henriette Henze, M. Juliane Jung, Lennart Gresing, Véronique Blanchard, Julia von Maltzahn, Christian A. Hübner, Patricia Franzka
Guanosine diphosphate-mannose pyrophosphorylase B (GMPPB) catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, which is required as a mannose donor for the biosynthesis of glycan structures necessary for proper cellular functions. Mutations in GMPPB have been associated with various neuromuscular disorders such as muscular dystrophy and myasthenic syndromes. Here, we report that
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Astrocytes in intracerebral hemorrhage: impact and therapeutic objectives Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-14 Hao Dong, Xin Wen, Bai-Wen Zhang, Zhe Wu, Wei Zou
Intracerebral hemorrhage (ICH) manifests precipitously and profoundly impairs the neurological function in patients who are affected. The etiology of subsequent injury post-ICH is multifaceted, characterized by the intricate interplay of various factors, rendering therapeutic interventions challenging. Astrocytes, a distinct class of glial cells, interact with neurons and microglia, and are implicated
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Role of TRAK1 variants in epilepsy: genotype–phenotype analysis in a pediatric case of epilepsy with developmental disorder Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-12 Ren-Ke Li, Yu-Rong Xiong, Shu-Jing Pan, Wen-Ting Lei, Xiao-Mei Shu, Xiao-Qi Shi, Mao-Qiang Tian
PurposeThe TRAK1 gene is mapped to chromosome 3p22.1 and encodes trafficking protein kinesin binding 1. The aim of this study was to investigate the genotype–phenotype of TRAK1-associated epilepsy.MethodsTrio-based whole-exome sequencing was performed on a cohort of 98 patients with epilepsy of unknown etiologies. Protein modeling and the VarCards database were used to predict the damaging effects
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Different reactive profiles of calmodulin in the CSF samples of Chinese patients of four types of genetic prion diseases Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-08 Xiao-Xi Jia, Chao Hu, Cao Chen, Li-Ping Gao, Dong-Lin Liang, Wei Zhou, Run-Dong Cao, Kang Xiao, Qi Shi, Xiao-Ping Dong
Background and purposeCalmodulin (CaM) levels exhibit significant elevation in the brain tissue of rodent and cell line models infected with prion, as well as in the cerebrospinal fluid (CSF) samples from patients diagnosed with sporadic Creutzfeldt-Jakob disease (sCJD). However, the status of CSF CaM in patients with genetic prion diseases (gPrDs) remains unclear. This study aims to assess the characteristics
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Identification of hub genes significantly linked to temporal lobe epilepsy and apoptosis via bioinformatics analysis Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-07 Weiliang Wang, Yinghao Ren, Fei Xu, Xiaobin Zhang, Fengpeng Wang, Tianyu Wang, Huijuan Zhong, Xin Wang, Yi Yao
BackgroundEpilepsy stands as an intricate disorder of the central nervous system, subject to the influence of diverse risk factors and a significant genetic predisposition. Within the pathogenesis of temporal lobe epilepsy (TLE), the apoptosis of neurons and glial cells in the brain assumes pivotal importance. The identification of differentially expressed apoptosis-related genes (DEARGs) emerges as
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Restoring GABAB receptor expression in the ventral tegmental area of methamphetamine addicted mice inhibits locomotor sensitization and drug seeking behavior Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-07 Mohammad Hleihil, Dietmar Benke
Repeated exposure to psychostimulants such as methamphetamine (METH) induces neuronal adaptations in the mesocorticolimbic dopamine system, including the ventral tegmental area (VTA). These changes lead to persistently enhanced neuronal activity causing increased dopamine release and addictive phenotypes. A factor contributing to increased dopaminergic activity in this system appears to be reduced
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Electrical and chemical modulation of homogeneous and heterogeneous human-iPSCs-derived neuronal networks on high density arrays Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-06 Giulia Parodi, Giorgia Zanini, Michela Chiappalone, Sergio Martinoia
The delicate “Excitatory/Inhibitory balance” between neurons holds significance in neurodegenerative and neurodevelopmental diseases. With the ultimate goal of creating a faithful in vitro model of the human brain, in this study, we investigated the critical factor of heterogeneity, focusing on the interplay between excitatory glutamatergic (E) and inhibitory GABAergic (I) neurons in neural networks
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Exploring gene signatures and regulatory networks in a rat model of sciatica: implications and validation in neuropathic pain Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-06 Mu Xu, Zhijian Wang, Gang Xu, Mengye Zhu, Daying Zhang, Yi Yan
BackgroundSciatica (neuropathic pain [NP]) is a common disease characterized by pain from radiation along the sciatic nerve. The aim of this study was to study the genes associated with chronic systolic injury of sciatic nerve (SCN-CCI) in rats by RNA-Seq technique, and to explore their potential as therapeutic targets.MethodsSciatic nerve rat model was obtained by ligation of sciatic nerve and divided
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Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-05 Stephanie L. Grella, Tia N. Donaldson
Here, we review the basis of contextual memory at a conceptual and cellular level. We begin with an overview of the philosophical foundations of traversing space, followed by theories covering the material bases of contextual representations in the hippocampus (engrams), exploring functional characteristics of the cells and subfields within. Next, we explore various methodological approaches for investigating
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Adhesion-clutch between DCC and netrin-1 mediates netrin-1–induced axonal haptotaxis Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-05 Zhen Qiu, Takunori Minegishi, Daichi Aoki, Kouki Abe, Kentarou Baba, Naoyuki Inagaki
The growth cone, a motile structure located at the tip of growing axons, senses extracellular guidance cues and translates them into directional forces that drive axon outgrowth and guidance. Axon guidance directed by chemical cues on the extracellular adhesive substrate is termed haptotaxis. Recent studies reported that netrin-1 on the substrate functions as a haptotactic axon guidance cue. However
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Transcriptome profile analysis in spinal cord injury rats with transplantation of menstrual blood-derived stem cells Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-02 Longju Qi, Wenwei Jiang, Wenhua He, Xiangzhe Li, Jiahuan Wu, Shiyuan Chen, Zehua Liao, Shumin Yu, Jinyi Liu, Yuyu Sun, Qinfeng Wu, Chuanming Dong, Qinghua Wang
IntroductionMenstrual blood-derived stem cells (MenSCs) are vital in treating many degenerative and traumatic disorders. However, the underlying molecular mechanisms remain obscure in MenSCs-treating spinal cord injury (SCI) rats.MethodsMenSCs were adopted into the injured sites of rat spinal cords at day 7 post surgery and the tissues were harvested for total RNA sequencing analysis at day 21 after
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Revisiting the calpain hypothesis of learning and memory 40 years later Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-02-01 Michel Baudry, Xiaoning Bi
In 1984, Gary Lynch and Michel Baudry published in Science a novel biochemical hypothesis for learning and memory, in which they postulated that the calcium-dependent protease, calpain, played a critical role in regulating synaptic properties and the distribution of glutamate receptors, thereby participating in memory formation in hippocampus. Over the following 40 years, much work has been done to
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The coherence between PSMC6 and α-ring in the 26S proteasome is associated with Alzheimer’s disease Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-31 Jing Xiong, Xinping Pang, Xianghu Song, Lin Yang, Chaoyang Pang
Alzheimer’s disease (AD) is a heterogeneous age-dependent neurodegenerative disorder. Its hallmarks involve abnormal proteostasis, which triggers proteotoxicity and induces neuronal dysfunction. The 26S proteasome is an ATP-dependent proteolytic nanomachine of the ubiquitin-proteasome system (UPS) and contributes to eliminating these abnormal proteins. This study focused on the relationship between
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Mechanisms of transcranial direct current stimulation (tDCS) for pain in patients with fibromyalgia syndrome Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-30 Shan Wang, Shu-Hao Du, Xue-Qiang Wang, Jun-Yan Lu
Fibromyalgia syndrome (FMS) is a recurrent pain condition that can be challenging to treat. Transcranial direct current stimulation (tDCS) has become a promising non-invasive therapeutic option in alleviating FMS pain, but the mechanisms underlying its effectiveness are not yet fully understood. In this article, we discuss the most current research investigating the analgesic effects of tDCS on FMS
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Human iPSC-derived neurons reveal NMDAR-independent dysfunction following HIV-associated insults Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-29 Alexander Starr, Emily Nickoloff-Bybel, Razan Abedalthaqafi, Naela Albloushi, Kelly L. Jordan-Sciutto
The central nervous system encounters a number of challenges following HIV infection, leading to increased risk for a collection of neurocognitive symptoms clinically classified as HIV-associated neurocognitive disorders (HAND). Studies attempting to identify causal mechanisms and potential therapeutic interventions have historically relied on primary rodent neurons, but a number of recent reports
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Methods to extract and analyze fluid from human pluripotent stem cell-derived choroid plexus organoids Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-29 Leon H. Chew, Eloi Mercier, Jason C. Rogalski, Sara Pippard, Erin Knock
The choroid plexus (ChP) is a highly vascularized tissue lining the ventricular space of the brain. The ChP generates cerebrospinal fluid (CSF) and forms a protective barrier in the central nervous system (CNS). Recently, a three-dimensional human pluripotent stem cell (hPSC)-derived ChP organoid model has been developed. This model generates cystic structures that are filled with a fluid resembling
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Role of C9orf72 hexanucleotide repeat expansions in ALS/FTD pathogenesis Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-22 Yanyan Geng, Qixu Cai
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive neurological disorders that share neurodegenerative pathways and features. The most prevalent genetic causes of ALS/FTD is the GGGGCC hexanucleotide repeat expansions in the first intron region of the chromosome 9 open reading frame 72 (C9orf72) gene. In this review, we comprehensively summarize the accumulating evidences
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Aging differentially alters the transcriptome and landscape of chromatin accessibility in the male and female mouse hippocampus Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-22 Jennifer M. Achiro, Yang Tao, Fuying Gao, Chia-Ho Lin, Marika Watanabe, Sylvia Neumann, Giovanni Coppola, Douglas L. Black, Kelsey C. Martin
Aging-related memory impairment and pathological memory disorders such as Alzheimer’s disease differ between males and females, and yet little is known about how aging-related changes in the transcriptome and chromatin environment differ between sexes in the hippocampus. To investigate this question, we compared the chromatin accessibility landscape and gene expression/alternative splicing pattern
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Tetrandrine alleviates oxaliplatin-induced mechanical allodynia via modulation of inflammation-related genes Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-18 Zhi-Ling Zhang, Zi-Yang Wu, Feng-Yu Liu, Hang-YuChen, Suo-Di Zhai
Oxaliplatin, a platinum-based chemotherapy drug, causes neuropathic pain, yet effective pharmacological treatments are lacking. Previously, we showed that tetrandrine (TET), with anti-inflammatory properties, reduces mechanical allodynia in nerve-injured mice. This study explores the effect of TET on oxaliplatin-induced mechanical allodynia and gene changes in mice. Male C57BL/6J mice received oxaliplatin
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Quantification of AMPA receptor subunits and RNA editing-related proteins in the J20 mouse model of Alzheimer’s disease by capillary western blotting Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-17 Luke T. Milham, Gary P. Morris, Lyndsey M. Konen, Peggy Rentsch, Nesli Avgan, Bryce Vissel
IntroductionAccurate modelling of molecular changes in Alzheimer’s disease (AD) dementia is crucial for understanding the mechanisms driving neuronal pathology and for developing treatments. Synaptic dysfunction has long been implicated as a mechanism underpinning memory dysfunction in AD and may result in part from changes in adenosine deaminase acting on RNA (ADAR) mediated RNA editing of the GluA2
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Reduction of inflammation and mitochondrial degeneration in mutant SOD1 mice through inhibition of voltage-gated potassium channel Kv1.3 Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-16 Patrizia Ratano, Germana Cocozza, Cecilia Pinchera, Ludovica Maria Busdraghi, Iva Cantando, Katiuscia Martinello, Mariarosaria Scioli, Maria Rosito, Paola Bezzi, Sergio Fucile, Heike Wulff, Cristina Limatola, Giuseppina D’Alessandro
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no effective therapy, causing progressive loss of motor neurons in the spinal cord, brainstem, and motor cortex. Regardless of its genetic or sporadic origin, there is currently no cure for ALS or therapy that can reverse or control its progression. In the present study, taking advantage of a human superoxide dismutase-1
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A novel hydro-pneumatic fluid percussion device for inducing traumatic brain injury: assessment of sensory, motor, cognitive, molecular, and morphological outcomes in rodents Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-16 Alberto Morales-Villagrán, Juan C. Salazar-Sánchez, Gustavo A. Chiprés-Tinajero, Laura Medina-Ceja, Jorge Ortega-Ibarra
IntroductionThe fluid percussion method is widely used to induce brain injury in rodents. However, this approach has several limitations, including variability in the resulting damage, which is attributed to factors such as manual control of the mass used to generate the desired pressure. To address these issues, several modifications to the original method have been proposed.MethodsIn this study,
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ΔFosB is part of a homeostatic mechanism that protects the epileptic brain from further deterioration Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-12 Jerome Clasadonte, Tania Deprez, Gabriel S. Stephens, Georges Mairet-Coello, Pierre-Yves Cortin, Maxime Boutier, Aurore Frey, Jeannie Chin, Marek Rajman
Activity induced transcription factor ΔFosB plays a key role in different CNS disorders including epilepsy, Alzheimer’s disease, and addiction. Recent findings suggest that ΔFosB drives cognitive deficits in epilepsy and together with the emergence of small molecule inhibitors of ΔFosB activity makes it an interesting therapeutic target. However, whether ΔFosB contributes to pathophysiology or provides
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Unraveling the complex relationship between prenatal alcohol exposure, hippocampal LTP, and learning and memory Front. Mol. Neurosci. (IF 4.8) Pub Date : 2024-01-12 Monica Goncalves-Garcia, Derek Alexander Hamilton
Prenatal alcohol exposure (PAE) has been extensively studied for its profound impact on neurodevelopment, synaptic plasticity, and cognitive outcomes. While PAE, particularly at moderate levels, has long-lasting cognitive implications for the exposed individuals, there remains a substantial gap in our understanding of the precise mechanisms underlying these deficits. This review provides a framework