-
RELN gene-related drug-resistant epilepsy with periventricular nodular heterotopia treated with radiofrequency thermocoagulation: a case report Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Zijian Li, Fuli Wang, Zhidong He, Qi Guo, Jinnan Zhang, Songyan Liu
An increasing number of gene mutations associated with epilepsy have been identified, some linked to gray matter heterotopia—a common cause of drug-resistant epilepsy. Current research suggests that gene mutation-associated epilepsy should not be considered a contraindication for surgery in epilepsy patients. At present, stereoelectroencephalography-guided radiofrequency thermocoagulation is an important
-
Strength of spatial correlation between gray matter connectivity and patterns of proto-oncogene and neural network construction gene expression is associated with diffuse glioma survival Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Shelli R. Kesler, Rebecca A. Harrison, Alexa De La Torre Schutz, Hayley Michener, Paris Bean, Veronica Vallone, Sarah Prinsloo
IntroductionLike other forms of neuropathology, gliomas appear to spread along neural pathways. Accordingly, our group and others have previously shown that brain network connectivity is highly predictive of glioma survival. In this study, we aimed to examine the molecular mechanisms of this relationship via imaging transcriptomics.MethodsWe retrospectively obtained presurgical, T1-weighted MRI datasets
-
Sensitivity of the African neuropsychology battery memory subtests and learning slopes in discriminating APOE 4 and amyloid pathology in adult individuals in the Democratic Republic of Congo Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Jean Ikanga, Sarah D. Patrick, Megan Schwinne, Saranya Sundaram Patel, Emmanuel Epenge, Guy Gikelekele, Nathan Tshengele, Immaculee Kavugho, Samuel Mampunza, Kevin E. Yarasheski, Charlotte E. Teunissen, Anthony Stringer, Allan Levey, Julio C. Rojas, Brandon Chan, Argentina Lario Lago, Joel H. Kramer, Adam L. Boxer, Andreas Jeromin, Alvaro Alonso, Robert J. Spencer
BackgroundThe current study examined the sensitivity of two memory subtests and their corresponding learning slope metrics derived from the African Neuropsychology Battery (ANB) to detect amyloid pathology and APOEε4 status in adults from Kinshasa, the Democratic Republic of the Congo.Methods85 participants were classified for the presence of β-amyloid pathology and based on allelic presence of APOEε4
-
Abnormalities of white matter network properties in middle-aged and elderly patients with functional constipation Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Hou Xueyan, Ai Qi, Song Chunming, Zhi Yu, Weng Wencai
PurposeTo explore white matter network topological properties changes in middle-aged and elderly patients with functional constipation (Functional Constipation, FC) by diffusion tensor imaging (DTI), and to evaluate the correlation between the abnormal changes and clinical data.Methods29 FC patients and 31 age- and sex-matched healthy controls (HC) were recruited. Magnetic resonance imaging and clinical
-
Technical success, procedural safety, and efficacy of the Silk Vista Baby in the treatment of cerebral aneurysms over a mid-to-long-term follow-up Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Claudio Rodríguez-Fernández, Pedro Ruiz-Garcia, Maria Jesús Garcia-Sanchez, Martiel Manrique-Zegarra, Carlos Toledano-Illán, Jorge Escartin, Miguel Angel Vences, Luis Angel Rubio, Alex Luttich, José Manuel Pumar
BackgroundLong-term follow-up of cerebral aneurysms treated with the Silk Vista Baby (SVB) flow diverter is lacking. This study aimed to assess the technical success, procedural safety, and efficacy of the SVB (Balt, Montmorency, France) for the treatment of intracranial aneurysms in small cerebral vessels over a mid-to long-term follow-up.MethodsWe retrospectively analyzed a prospectively maintained
-
Polymyxin-induced neuromuscular weakness: a case report Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Amanda X. Y. Chin, Kay W. P. Ng, Yee Cheun Chan, Yihui Goh, Rahul Rathakrishnan
Polymyxin-induced neuromuscular blockade is a rare but potentially fatal condition, with majority of cases that were reported between 1962 and 1973. We describe a patient who developed hypercapnic respiratory failure after initiation of polymyxin for multi-drug resistant Escherichia Coli bacteremia, due to polymyxin-induced neuromuscular dysfunction. After cessation of polymyxin, he regained full strength
-
Using a k-means clustering to identify novel phenotypes of acute ischemic stroke and development of its Clinlabomics models Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Yao Jiang, Yingqiang Dang, Qian Wu, Boyao Yuan, Lina Gao, Chongge You
ObjectiveAcute ischemic stroke (AIS) is a heterogeneous condition. To stratify the heterogeneity, identify novel phenotypes, and develop Clinlabomics models of phenotypes that can conduct more personalized treatments for AIS.MethodsIn a retrospective analysis, consecutive AIS and non-AIS inpatients were enrolled. An unsupervised k-means clustering algorithm was used to classify AIS patients into distinct
-
Choosing the optimal target area for repeated transcranial magnetic stimulation in treating neuropathic pain in spinal cord injury patients: a comparative analysis Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Lihua Jin, Haonan Wang, Yifei Dong, Qian Chen, Linrong Li, Yongmei Li
ObjectiveThe specific target area of repeated transcranial magnetic stimulation (rTMS) in treating neuropathic pain resulting from spinal cord injury (SCI-NP) remains uncertain.MethodsThirty-four participants with SCI-NP were allocated into three groups, namely, the motor cortex (M1, A) group, the left dorsolateral prefrontal cortex (LDLPFC, B) group, and the control (sham stimulation, C) group. The
-
Dural arteriovenous fistula and sinus thrombosis presenting as parkinsonism and dementia: a case report with literature review Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Ranran Tu, Qihua Chen, Lixia Qin
IntroductionDural arteriovenous fistula (DAVF) is an uncommon malformation involving an abnormal connection between dural arteries, or the pachymeningeal branches of cerebral arteries, and dural veins. Its exact pathogenesis remains elusive. Known potential triggers for DAVF include cerebral venous sinus thrombosis (CVST), trauma, ear infections, and cranial surgeries. Due to its rarity and diverse
-
Systematic review on the frequency of occurrence in nerve branches and the side of the face involved in trigeminal neuralgia and its clinical implication Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Assefa Agegnehu Teshome, Gashaw Walle Ayehu, Berhanu Kindu Ashagrie, Nega Dagnaw Baye, Atalo Agemas Ayenew, Misganaw Asmamaw Mengstie, Taklo Simineh Yazie, Asaye Alamneh Gebeyehu, Ermias Sisay Chanie, Yalew Melkamu Molla, Molla Taye Jemberie, Agmas Wassie Abate
PurposeThe purpose of this systematic review is to answer the focused question, “What is the commonly affected nerve branch and the side of the face involved in trigeminal neuralgia?”Types of studies reviewedThis systematic review included studies reporting commonly affected trigeminal nerve branches and the side of the face involved in trigeminal neuralgia. To find the potential studies published
-
Case report: A novel case of paraneoplastic voltage gated calcium channel antibodies secondary to appendiceal adenocarcinoma Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Ghanshyam Patel, Ahmet Sakiri, Abby Brown, Arfa Pasha, Vibhav Bansal
Voltage gated calcium channels (VGCCs) play a critical role in neural transmission. Antibodies that target these ion channels can disrupt cellular signal transmission resulting in various clinical presentations. VGCC antibodies are most commonly associated with paraneoplastic syndromes such as Lambert-Eatons myasthenic syndrome. Here, we report a 47-year-old female with Stage IV appendiceal adenocarcinoma
-
Relationships between irregular pulsation and variations in morphological characteristics during the cardiac cycle in unruptured intracranial aneurysms by 4D-CTA Front. Neurol. (IF 3.4) Pub Date : 2024-03-27 Shiyao Chen, Nan Lv, Yu Qian, Mingwei Zhang, Tianyi Zhang, Yunzhang Cheng
Background and purposeIrregular pulsation of the aneurysmal wall has been suggested as a novel predictor for aneurysm rupture. Aneurysm volume variations during the cardiac cycle and the association between irregular pulsation and morphological features have been discussed, but the clinical significance remains unclear. The purpose of this study was to quantify changes in morphological characteristics
-
Digital biomarkers from gaze tests for classification of central and peripheral lesions in acute vestibular syndrome Front. Neurol. (IF 3.4) Pub Date : 2024-03-26 Benjamin Duvieusart, Terence S. Leung, Nehzat Koohi, Diego Kaski
Acute vestibular syndrome (AVS) is characterised by a sudden vertigo, gait instability, nausea and nystagmus. Accurate and rapid triage of patients with AVS to differentiate central (potentially sinister) from peripheral (usually benign) root causes is a challenge faced across emergency medicine settings. While there exist bedside exams which can reliably differentiate serious cases, they are underused
-
The characteristic and prognostic role of blood inflammatory markers in patients with Huntington’s disease from China Front. Neurol. (IF 3.4) Pub Date : 2024-03-26 Jie-Qiang Xia, Yang-Fan Cheng, Si-Rui Zhang, Yuan-Zheng Ma, Jia-Jia Fu, Tian-Mi Yang, Ling-Yu Zhang, Jean-Marc Burgunder, Hui-Fang Shang
ObjectivesThis study aims to elucidate the role of peripheral inflammation in Huntington’s disease (HD) by examining the correlation of peripheral inflammatory markers with clinical manifestations and disease prognosis.MethodsThis investigation involved 92 HD patients and 92 matched healthy controls (HCs). We quantified various peripheral inflammatory markers and calculated their derived metrics including
-
Time of the day and season distribution among stroke code subtypes: differences between ischemic stroke, intracranial hemorrhage, and stroke mimic Front. Neurol. (IF 3.4) Pub Date : 2024-03-26 Alex Menéndez Albarracín, Adrián Valls Carbó, Neus Rabaneda Lombarte, Bárbara Yugueros Baena, Jaime Carbonell Gisbert, Belén Flores-Pina, Maria-Clara Larrañaga De Bofarull, Marina Martínez Sánchez, María Hernández-Pérez, Alejandro Bustamante Rangel, Laura Dorado Bouix, Meritxell Gomis Cortina, Mònica Millán Tornè, Natalia Pérez de la Ossa
BackgroundCircadian variations in the timing of the onset of stroke symptoms have been described, showing a morning excess of cardiovascular risk. To date, no differences have been found between stroke subtype and time distribution throughout the day. The present study aims to compare the seasonal and circadian rhythm of symptoms onset in ischemic, hemorrhagic, and stroke mimic patients.MethodsThis
-
Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted magnetic resonance imaging Front. Neurol. (IF 3.4) Pub Date : 2024-03-26 Samuel Lamon, Priscille de Dumast, Thomas Sanchez, Vincent Dunet, Léo Pomar, Yvan Vial, Mériam Koob, Meritxell Bach Cuadra
ObjectiveTo assess the accuracy of corpus callosum (CC) biometry, including sub-segments, using 3D super-resolution fetal brain MRI (SR) compared to 2D or 3D ultrasound (US) and clinical low-resolution T2-weighted MRI (T2WS).MethodFetal brain biometry was conducted by two observers on 57 subjects [21–35 weeks of gestational age (GA)], including 11 cases of partial CC agenesis. Measures were performed
-
Case report: Insulinoma masquerades as epilepsy – quantitative EEG analysis Front. Neurol. (IF 3.4) Pub Date : 2024-03-26 Natalia Kostolanska, Petr Klimes, Jitka Kocvarova, Hana Pikulova, Ondrej Strycek, Milan Brazdil, Irena Dolezalova
Insulinomas are rare gastrointestinal tumors with an incidence of 1–3 per million inhabitants annually. These tumors result in excessive insulin production, culminating in hypoglycemia. Such hypoglycemia triggers various central nervous system (CNS) manifestations, including headache, confusion, abnormal behavior, and epileptic seizures, which can lead to misdiagnosis as epilepsy. This case report
-
Interactions between Schwann cell and extracellular matrix in peripheral nerve regeneration Front. Neurol. (IF 3.4) Pub Date : 2024-03-26 Maorong Jiang, Chen Muyang, Nana Liu
Peripheral nerve injuries, caused by various reasons, often lead to severe sensory, motor, and autonomic dysfunction or permanent disability, posing a challenging problem in regenerative medicine. Autologous nerve transplantation has been the gold standard in traditional treatments but faces numerous limitations and risk factors, such as donor area denervation, increased surgical complications, and
-
The evolution of ventral intermediate nucleus targeting in MRI-guided focused ultrasound thalamotomy for essential tremor: an international multi-center evaluation Front. Neurol. (IF 3.4) Pub Date : 2024-03-26 Ayesha Jameel, Sena Akgun, Nada Yousif, Joely Smith, Brynmor Jones, Dipankar Nandi, Peter Bain, Wladyslaw Gedroyc
BackgroundThe ventral intermediate nucleus (VIM) is the premiere target in magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy for tremor; however, there is no consensus on the optimal coordinates for ablation. This study aims to ascertain the various international VIM targeting approaches (VIM-TA) and any evolution in practice.MethodsInternational MRgFUS centers were invited to share
-
Associations between the burdens of comorbid sleep problems, central sensitization, and headache-related disability in patients with migraine Front. Neurol. (IF 3.4) Pub Date : 2024-03-26 Keisuke Suzuki, Shiho Suzuki, Yasuo Haruyama, Kei Funakoshi, Hiroaki Fujita, Hirotaka Sakuramoto, Mai Hamaguchi, Gen Kobashi, Koichi Hirata
ObjectiveSleep disturbances are common in migraine patients and affect quality of life. Central sensitization (CS) is likely to play a role in the increased severity and chronicity of migraine. We hypothesized that the number of comorbid sleep problems would affect headache-related disability through the effects of central sensitization (CS).MethodsWe performed a cross-sectional study including 215
-
Focused ultrasound therapy in movement disorders: management roadmap toward optimal pathway organization Front. Neurol. (IF 3.4) Pub Date : 2024-03-26 Sara Rinaldo, Roberto Cilia, Valentina Leta, Mariarosaria Gammone, Nico Golfrè Andreasi, Fabiana Colucci, Arianna Braccia, Roberta Telese, Marco Fusar Poli, Vincenzo Levi, Luigi Michele Antonio Romito, Francesco Ghilemetti, Elena De Martin, Maria Luisa Fumagalli, Francesca Epifani, Sara Prioni, Paolo Amami, Sylvie Piacentini, Antonio Emanuele Elia, Grazia Devigili, Vittoria Nazzi, Elisa Francesca Maria
MRI-guided focused ultrasound (MRgFUS) lesioning is an innovative, safe and effective treatment which provides an innovative development in the field of minimally invasive stereotactic neurosurgery. Based on the application of focused ultrasound energy under full MR planning and thermal imaging control, unilateral lesioning of the thalamus, subthalamic nucleus, and globus pallidus is indicated for
-
A systematic review of the clinical evidence for an association between type I hypersensitivity and inner ear disorders Front. Neurol. (IF 3.4) Pub Date : 2024-03-25 Bin Zeng, Ewa Domarecka, Lingyi Kong, Heidi Olze, Jörg Scheffel, Sherezade Moñino-Romero, Frank Siebenhaar, Agnieszka J. Szczepek
Inner ear disorders have a variety of causes, and many factors can contribute to the exacerbation of cochlear and vestibular pathology. This systematic review aimed to analyze clinical data on the coexistence and potential causal interaction between allergic diseases and inner ear conditions. A search of PubMed and Web of Science identified 724 articles, of which 21 were selected for full-text analysis
-
Optimal dose of fenfluramine in adjuvant treatment of drug-resistant epilepsy: evidence from randomized controlled trials Front. Neurol. (IF 3.4) Pub Date : 2024-03-25 Yingchun Xu, Deng Chen, Ling Liu
ObjectiveSeveral clinical trials have suggested that fenfluramine (FFA) is effective for the treatment of epilepsy in Dravet syndrome (DS) and Lennox–Gastaut syndrome (LGS). However, the exploration of its optimal target dose is ongoing. This study aimed to summarize the best evidence to inform this clinical issue.Materials and methodsWe searched PubMed, Embase (via Ovid), and Web of Science for relevant
-
Clinical utility of plasma Aβ42/40 ratio by LC-MS/MS in Alzheimer’s disease assessment Front. Neurol. (IF 3.4) Pub Date : 2024-03-25 Darren M. Weber, Steven W. Taylor, Robert J. Lagier, Jueun C. Kim, Scott M. Goldman, Nigel J. Clarke, David E. Vaillancourt, Ranjan Duara, Karen N. McFarland, Wei-en Wang, Todd E. Golde, Michael K. Racke
IntroductionPlasma Aβ42/40 ratio can help predict amyloid PET status, but its clinical utility in Alzheimer’s disease (AD) assessment is unclear.MethodsAβ42/40 ratio was measured by LC-MS/MS for 250 specimens with associated amyloid PET imaging, diagnosis, and demographic data, and for 6,192 consecutive clinical specimens submitted for Aβ42/40 testing.ResultsHigh diagnostic sensitivity and negative
-
Linguistic changes in neurodegenerative diseases relate to clinical symptoms Front. Neurol. (IF 3.4) Pub Date : 2024-03-25 Melisa Gumus, Morgan Koo, Christa M. Studzinski, Aparna Bhan, Jessica Robin, Sandra E. Black
BackgroundThe detection and characterization of speech changes may help in the identification and monitoring of neurodegenerative diseases. However, there is limited research validating the relationship between speech changes and clinical symptoms across a wide range of neurodegenerative diseases.MethodWe analyzed speech recordings from 109 patients who were diagnosed with various neurodegenerative
-
Elevated troponin levels as a predictor of mortality in patients with acute stroke: a systematic review and meta-analysis Front. Neurol. (IF 3.4) Pub Date : 2024-03-25 Annu Gulia, Manyata Srivastava, Pradeep Kumar
Background and AimThe prognostic potential of cardiac troponin (cTn) in acute stroke patients has been a subject of ongoing debate. Our objective was to provide a comprehensive evidence for predicting mortality in acute stroke patients by using the elevated troponin levels.MethodsWe conducted an extensive literature search, including PubMed, EMbase, and Trip Databases, covering studies published up
-
A novel nomogram to predict futile recanalization in patients with acute ischemic stroke undergoing mechanical thrombectomy Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Cheng-cai Lai, Yin-dan Yao, Xia Li, Ao-fei Liu, Chen Li, Yun-e Liu, Chang-chun Jiang, Ying-ying Zhang, Min Jin, Jin Lv, Wei-jian Jiang
Background and objectiveFutile recanalization (FR) is defined as patients with acute ischemic stroke (AIS) due to large vessel occlusion who still exhibits functional dependence although undergoing successful mechanical thrombectomy (MT). We aimed to develop and validate a simple nomogram for predicting the probability of FR after MT treatment in AIS patients.MethodsClinical data of AIS patients in
-
The ratio of the maximum density values: a new method for predicting hemorrhagic transformation in acute ischemic stroke patients undergoing mechanical thrombectomy Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Xiaohong Qiao, Fuhao Zheng, Manman Wei, Zhenming Zhao
BackgroundIt is challenging yet critical to differentiate between hemorrhagic transformation (HT) and contrast extravasation on non-contrast-enhanced computed tomography (NCCT) scans following mechanical thrombectomy (MT) in patients with acute ischemic stroke. We propose a new method called the ratio of maximum density values (RMDV) to minimize the confusion of contrast extravasation and to evaluate
-
Multiple sclerosis in a 4-year-old boy: a case report and literature review Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Ula Arkar, Tina Vipotnik Vesnaver, Damjan Osredkar, Mirjana Perković Benedik, Neli Bizjak
Pediatric onset multiple sclerosis (POMS) in the very young is a very rare entity and presents a difficult diagnostic challenge due to overlapping signs and symptoms with other diseases. We present a 4-year-old boy who initially presented with right-sided hemiparesis and demyelinating lesions on MRI. Follow-up MRI examinations 3 and 6 months later revealed new demyelinating lesions. Ten months after
-
Post-COVID postural orthostatic tachycardia syndrome (POTS): a new phenomenon Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Christopher Cantrell, Conor Reid, Claudia S. Walker, Samantha J. Stallkamp Tidd, Ryan Zhang, Robert Wilson
BackgroundThe impact of COVID-19 has been far-reaching, and the field of neurology is no exception. Due to the long-hauler effect, a variety of chronic health consequences have occurred for some post-COVID patients. A subset of these long-hauler patients experienced symptoms of autonomic dysfunction and tested positive for postural orthostatic tachycardia syndrome (POTS) via autonomic testing.MethodsWe
-
Modulations of resting-static functional connectivity on insular by electroacupuncture in subjective tinnitus Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Bixiang Zha, Yating Zhang, Feifei Shi, Ling Cheng, Zhihao Rong, Leiyu Yu, Wanting Liu, Qiuju Xue, Min Ye, Jinying Yang, Bensheng Qiu, Jun Yang
ObjectiveTo explore the modulations of electroacupuncture in subjective tinnitus (ST) by comparing the difference of functional connectivity (FC) in ST patients and healthy volunteers between the insular (INS) and the whole brain region.MethodsA total of 34 ST patients were selected into electroacupuncture group (EG) and 34 age- and sex-matched normal subjects were recruited into control group (CG)
-
Comparative efficacy of acupuncture point stimulation treatments for dialysis patients with uremic pruritus: a systematic review and network meta-analysis Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Po-Hsuan Lu, Hui-En Chuo, Ling-Ya Chiu, Chien-Cheng Lai, Jen-Yu Wang, Ping-Hsun Lu
BackgroundUremic pruritus (UP) is a common complication of chronic kidney disease that causes sleep disturbances and increases all-cause mortality. Currently, the first-line medications for UP exhibit inadequate pruritus control with adverse effects. Various acupuncture point stimulation treatments (APSTs) have been shown to be effective as adjuvant therapies in UP, and a network meta-analysis can
-
Pre-hospital stroke monitoring past, present, and future: a perspective Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Hilla Ben Pazi, Shady Jahashan, Sagi Har Nof, Samuel Zibman, Ornit Yanai-Kohelet, Limor Prigan, Nathan Intrator, Natan M. Bornstein, Marc Ribo
Integrated brain-machine interface signifies a transformative advancement in neurological monitoring and intervention modalities for events such as stroke, the leading cause of disability. Historically, stroke management relied on clinical evaluation and imaging. While today’s stroke landscape integrates artificial intelligence for proactive clinical decision-making, mainly in imaging and stroke detection
-
TOAST stroke subtype classification in clinical practice: implications for the Get With The Guidelines-Stroke nationwide registry Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Cecelia M. Rathburn, Katherine T. Mun, Latisha K. Sharma, Jeffrey L. Saver
IntroductionThe TOAST (Trial of ORG 10172 in Acute Stroke Treatment) is the most commonly used ischemic stroke subtype classification system worldwide and a required field in the US National Get With The Guidelines-Stroke (GWTG-Stroke) registry. However, stroke diagnostics have advanced substantially since the TOAST classification was designed 30 years ago, potentially making it difficult to apply
-
Clinical characteristics and MRI features of autoimmune glial fibrillary acidic protein astrocytopathy: a case series of 34 patients Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Gaotan Ke, Si Jian, Tingxin Yang, Xu Zhao
ObjectivesTo analyze the clinical and imaging characteristics of autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A).MethodsForty-three patients diagnosed with GFAP-A between March 2017 and July 2023 were retrospectively recruited. The clinical characteristics and magnetic resonance imaging (MRI) features were collected.ResultsTwenty-one patients (61.8%) had a fever and 16 (47.1%) had
-
Serum biomarkers in patients with drug-resistant epilepsy: a proteomics-based analysis Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Mian Ma, Ying Cheng, Xiaoxia Hou, Zhisen Li, Meixia Wang, Bodun Ma, Qingzhang Cheng, Zhiliang Ding, Hongxuan Feng
ObjectiveTo investigate the serum biomarkers in patients with drug-resistant epilepsy (DRE).MethodsA total of 9 DRE patients and 9 controls were enrolled. Serum from DRE patients was prospectively collected and analyzed for potential serum biomarkers using TMT18-labeled proteomics. After fine quality control, bioinformatics analysis was conducted to find differentially expressed proteins. Pathway enrichment
-
Altered tongue muscle contractile properties coincide with altered swallow function in the adult Ts65Dn mouse model of down syndrome Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Tiffany J. Glass, John A. Russell, Erin H. Fisher, Marziyeh Ostadi, Nanyumuzi Aori, Y. Eugene Yu, Nadine P. Connor
PurposeDown syndrome (DS) is a developmental disability associated with difficulties in deglutition. The adult Ts65Dn mouse model of DS has been previously shown to have differences in measures of swallowing compared with euploid controls. However, the putative mechanisms of these differences in swallowing function are unclear. This study tested the hypothesis that the Ts65Dn genotype is associated
-
Clinical experience in intracranial stenting of Wingspan stent system under local anesthesia Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Mao-Shih Lin, Chih-Wei Huang, Yuang-Seng Tsuei
ObjectiveThe use of endovascular treatments for symptomatic intracranial atherosclerosis disease (ICAD) remains contentious due to high periprocedural complications. Many centers resort to general anesthesia for airway protection and optimal periprocedural conditions; however, this approach lacks real-time monitoring of patients’ neurological status during procedures. In this study, we employed intracranial
-
Early cortico-muscular coherence and cortical network changes in Parkinson’s patients treated with MRgFUS Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Elisa Visani, Ferruccio Panzica, Silvana Franceschetti, Nico Golfrè Andreasi, Roberto Cilia, Sara Rinaldo, Davide Rossi Sebastiano, Paola Lanteri, Roberto Eleopra
IntroductionTo investigate cortical network changes using Magnetoencephalography (MEG) signals in Parkinson’s disease (PD) patients undergoing Magnetic Resonance-guided Focused Ultrasound (MRgFUS) thalamotomy.MethodsWe evaluated the MEG signals in 16 PD patients with drug-refractory tremor before and after 12-month from MRgFUS unilateral lesion of the ventralis intermediate nucleus (Vim) of the thalamus
-
Predictors of overload in parents of children with neuromuscular diseases Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 A. A. Rodríguez, M. García, Oscar Martínez, J. F. López-Paz, I. García, P. Pérez-Nuñez, I. Amayra
IntroductionParents of children with neuromuscular diseases experience multiple difficulties in their daily lives that affect their physical and psychological health. The risk factors for these health issues have not been sufficiently investigated. Therefore, the aim of this study was to analyze the potential predictors of overload in these parents, including QoL, somatic symptomatology, life satisfaction
-
Low-contrast visual acuity test is associated with central inflammation and predicts disability development in newly diagnosed multiple sclerosis patients Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Ettore Dolcetti, Fabio Buttari, Antonio Bruno, Federica Azzolini, Luana Gilio, Veronica Di Caprio, Gianluca Lauritano, Angela Borrelli, Giovanni Galifi, Roberto Furlan, Annamaria Finardi, Alessandra Musella, Livia Guadalupi, Georgia Mandolesi, Valentina Rovella, Diego Centonze, Mario Stampanoni Bassi
IntroductionThe visual system is a prominent site of damage in MS since the earliest phases of the disease. Altered low-contrast visual acuity (LCVA) test has been associated with visual impairment and retinal degeneration, predicting medium- and long-term disability. However, it is unclear whether LCVA may also represent a reliable measure of neuroinflammation and a predictor of disease evolution
-
Combined cortical thickness and blink reflex recovery cycle to differentiate essential tremor with and without resting tremor Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Camilla Calomino, Andrea Quattrone, Maria Giovanna Bianco, Rita Nisticò, Jolanda Buonocore, Marianna Crasà, Maria Grazia Vaccaro, Alessia Sarica, Aldo Quattrone
ObjectiveTo investigate the performance of structural MRI cortical and subcortical morphometric data combined with blink-reflex recovery cycle (BRrc) values using machine learning (ML) models in distinguishing between essential tremor (ET) with resting tremor (rET) and classic ET.MethodsWe enrolled 47 ET, 43 rET patients and 45 healthy controls (HC). All participants underwent brain 3 T-MRI and BRrc
-
Bridging the gap: improving correspondence between low-field and high-field magnetic resonance images in young people Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Rebecca Cooper, Rebecca A. Hayes, Mary Corcoran, Kevin N. Sheth, Thomas Campbell Arnold, Joel M. Stein, David C. Glahn, Maria Jalbrzikowski
BackgroundPortable low-field-strength magnetic resonance imaging (MRI) systems represent a promising alternative to traditional high-field-strength systems with the potential to make MR technology available at scale in low-resource settings. However, lower image quality and resolution may limit the research and clinical potential of these devices. We tested two super-resolution methods to enhance image
-
Endovascular treatment of symptomatic severe intracranial atherosclerotic stenosis with a novel intracranial dedicated drug-eluting stent: a more effective treatment approach Front. Neurol. (IF 3.4) Pub Date : 2024-03-22 Lin Ma, Fei Wang, Hao Feng, Shuo Yan, Ji-Chong Xu, Ying-Sheng Cheng, Chun Fang
BackgroundEndovascular treatment of severe intracranial atherosclerotic stenosis (ICAS) using coronary drug-eluting stents (DESs) significantly reduces the risk of in-stent restenosis (ISR) and stroke recurrence. However, there are few reports regarding the treatment of ICAS with intracranial dedicated DES. Herein, we present our experience with the feasibility, safety, and medium-term follow-up outcomes
-
Association of atopic dermatitis and headache disorder: a systematic review and meta-analyses Front. Neurol. (IF 3.4) Pub Date : 2024-03-21 Wei Yang, Hong Dai, Xiao-feng Xu, Hai-yin Jiang, Ji-yuan Ding
BackgroundGrowing evidence suggests that headache disorders and atopic dermatitis share similar pathological mechanisms and risk factors. The aim of this study was to assess the risk for headache disorders in patients with atopic dermatitis.MethodsWe systematically searched the PubMed and Embase databases from inception to December 1, 2023, for observational studies that examined risk of migraine in
-
SYN1 variant causes X-linked neurodevelopmental disorders: a case report of variable clinical phenotypes in siblings Front. Neurol. (IF 3.4) Pub Date : 2024-03-21 Bin Ren, Xiaoyan Wu, Yuqiang Zhou, Lijuan Chen, Jingzi Jiang
The SYN1 gene encodes synapsin I, variants within the SYN1 gene are linked to X-linked neurodevelopmental disorders with high clinical heterogeneity, with reflex epilepsies (REs) being a representative clinical manifestation. This report analyzes a Chinese pedigree affected by seizures associated with SYN1 variants and explores the genotype–phenotype correlation. The proband, a 9-year-old boy, experienced
-
Association between serum creatinine and 30 days all-cause mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: analysis of the MIMIC-IV database Front. Neurol. (IF 3.4) Pub Date : 2024-03-21 Yuan Zhong, Hao Sun, Wenjuan Jing, Lixian Liao, Jiayi Huang, Junqiang Ma, Weiqiang Chen
BackgroundSerum creatinine is a prognostic marker for various conditions, but its significance of spontaneous subarachnoid hemorrhage is still poorly understood. This study aims to elucidate the correlation between admission serum creatinine (sCr) levels and all-cause mortality within 30 days among individuals affected by non-traumatic subarachnoid hemorrhage (SAH).MethodsThis cohort study included
-
The impact of collateral therapeutics on stroke hemodynamics in normotensive and hypertensive rats: a step toward translation Front. Neurol. (IF 3.4) Pub Date : 2024-03-21 Marilyn J. Cipolla, Ryan D. Hunt, David S. Liebeskind, Sarah M. Tremble
IntroductionStroke interventions that increase collateral flow have the potential to salvage penumbral tissue and increase the number of patients eligible for reperfusion therapy. We compared the efficacy of two different collateral therapeutics during transient middle cerebral artery occlusion (tMCAO) in normotensive and hypertensive rats.MethodsThe change in collateral and core perfusion was measured
-
Marriage and childbearing in patients with epilepsy in Turkey Front. Neurol. (IF 3.4) Pub Date : 2024-03-21 Firdevs Ezgi Uçan Tokuç, Fatma Genç, Eylem Özaydın Göksu, Abidin Erdal, Yasemin Biçer Gömceli
IntroductionFor epilepsy, a common neurological disorder, brings psychosocial challenges like stigma, employment difficulties, and barriers to marriage and childbearing. Stigma often stems from misconceptions and societal beliefs, particularly in less developed regions like Turkey. However, research on the marital and childbearing experiences of epilepsy patients in such settings is limited. We aimed
-
Autosomal recessive primary microcephaly type 2 associated with a novel WDR62 splicing variant that disrupts the expression of the functional transcript Front. Neurol. (IF 3.4) Pub Date : 2024-03-21 Haizhu Chen, Ying Zheng, Hua Wu, Naiqing Cai, Guorong Xu, Yi Lin, Jin-Jing Li
BackgroundAutosomal recessive primary microcephaly (MCPH) is a rare neurodevelopmental disorder characterized primarily by congenital microcephaly and intellectual disability but without extra-central nervous system malformations. This investigation aimed to elucidate the genetic underpinnings of microcephaly in a patient from a Chinese consanguineous family.MethodsA comprehensive clinical assessment
-
Structural neuroimaging markers of normal pressure hydrocephalus versus Alzheimer’s dementia and Parkinson’s disease, and hydrocephalus versus atrophy in chronic TBI—a narrative review Front. Neurol. (IF 3.4) Pub Date : 2024-03-21 Sharada Kadaba Sridhar, Jen Dysterheft Robb, Rishabh Gupta, Scarlett Cheong, Rui Kuang, Uzma Samadani
IntroductionNormal Pressure Hydrocephalus (NPH) is a prominent type of reversible dementia that may be treated with shunt surgery, and it is crucial to differentiate it from irreversible degeneration caused by its symptomatic mimics like Alzheimer’s Dementia (AD) and Parkinson’s Disease (PD). Similarly, it is important to distinguish between (normal pressure) hydrocephalus and irreversible atrophy/degeneration
-
Case report: Simultaneous measurement of intracranial pressure and lumbar intrathecal pressure during epidural patch therapy for treating spontaneous intracranial hypotension syndrome. Spontaneous intracranial hypotension or spontaneous intraspinal hypovolume? Front. Neurol. (IF 3.4) Pub Date : 2024-03-21 Nicolas Engrand, Quentin Salardaine, Jean-Philippe Desilles, Cécile Echard, Pierre Bourdillon, Marc Williams, Guillaume Baille
ObjectivesSpontaneous intracranial hypotension (SIH) is frequently complicated by subacute subdural hematoma (SDH) and more rarely by bilateral thalamic ischemia. Here, we report a case of SIH-related SDH treated with three epidural patches (EPs), with follow-up of the intracranial pressure and lumbar intrathecal pressure.MethodsA 46-year-old man presented bilateral thalamic ischemia, then a growing
-
Prevalence and risk factors of early postoperative seizures in patients with glioma: a systematic review and meta-analysis Front. Neurol. (IF 3.4) Pub Date : 2024-03-20 Bo Sun, Yuchen Sun, Zijian Wang, Chao Zhao, Liang Yang
ObjectiveThis study aimed to explore the prevalence and risk factors of early postoperative seizures in patients with glioma through meta-analysis.MethodsCase–control studies and cohort studies on the prevalence and risk factors of early postoperative seizures in glioma patients were retrieved from various databases including CNKI, Wanfang, VIP, PubMed, Embase, Cochrane Library, and Web of Science
-
Case report: A novel mutation of glial fibrillary acidic protein gene causing juvenile-onset Alexander disease Front. Neurol. (IF 3.4) Pub Date : 2024-03-20 Carmela Romano, Emanuele Morena, Simona Petrucci, Selene Diamant, Martina Marconi, Lorena Travaglini, Ginevra Zanni, Maria Piane, Marco Salvetti, Silvia Romano, Giovanni Ristori
Alexander disease (AxD) is a rare inherited autosomal dominant (AD) disease with different clinical phenotypes according to the age of onset. It is caused by mutations in the glial fibrillary acid protein (GFAP) gene, which causes GFAP accumulation in astrocytes. A wide spectrum of mutations has been described. For some variants, genotype–phenotype correlations have been described, although variable
-
Differential impact of unilateral stroke on the bihemispheric motor cortex representation of the jaw and tongue muscles in young and aged rats Front. Neurol. (IF 3.4) Pub Date : 2024-03-20 Miranda J. Cullins, Nadine P. Connor
IntroductionDysphagia commonly occurs after stroke, yet the mechanisms of post-stroke corticobulbar plasticity are not well understood. While cortical activity associated with swallowing actions is bihemispheric, prior research has suggested that plasticity of the intact cortex may drive recovery of swallowing after unilateral stroke. Age may be an important factor as it is an independent predictor
-
Gait instability, ophthalmoplegia, and chorea with orofacial dyskinesia in a man with anti-Ri antibodies: a case report Front. Neurol. (IF 3.4) Pub Date : 2024-03-20 Mukuto Shioda, Hiroaki Fujita, Hiroki Onuma, Hirotaka Sakuramoto, Mai Hamaguchi, Keisuke Suzuki
A 79-year-old man was admitted for 2 weeks of dizziness, followed by diplopia, involuntary movement and progressive gait disturbances. Neurologic examination revealed horizontal and vertical gaze paresis, bilateral choreiform movement with orofacial dyskinesia, and limb/truncal ataxia. MRI revealed fluid-attenuated inversion recovery image-hyperintense signal abnormalities in the dorsal midbrain, pontine
-
IgLON5 autoimmunity in a patient with Creutzfeldt–Jakob disease: case report and review of literature Front. Neurol. (IF 3.4) Pub Date : 2024-03-20 Xiaofeng Li, Yimin Chen, Le Zhang, Wei Zhang, Bin Li, José Fidel Baizabal-Carvallo, Xingwang Song
ObjectiveWe present the case of a patient with clinical and imaging features of sporadic Creutzfeldt–Jakob disease (sCJD) and positive IgLON5 antibodies (Abs) in the serum and CSF.Case reportA 66-year-old Chinese man presented to the hospital with a stroke-like episode, followed by rapidly progressive cognitive decline, mutism, and parkinsonism. The MRI results showed a cortical ribboning sign in diffusion-weighted
-
Frontiers | Safety and efficacy of magnesium-rich artificial cerebrospinal fluid for subarachnoid hemorrhage Front. Neurol. (IF 3.4) Pub Date : 2024-03-19 Yawen Cheng, Xiangning Han, Wanfu Xie, Gaofeng Xu, Xiaobin Bai, Lei Qi, Linjuan Zhang, Rui Liu, Weihua Dong, Weiyi Feng, Chengsen Pang, Wei Zhang, Fude Liu, Xiangqi Cao, Yue Xu, Guogang Luo
Objectives This study aimed to investigate the efficacy of using a newly formulated magnesium-rich artificial cerebrospinal fluid (MACSF) as an alternative to normal saline (NS) for intraoperative irrigation during aneurysm clipping in improving the prognosis of patients with Aneurysmal subarachnoid hemorrhage (aSAH). Methods Patients with aSAH who underwent intraoperative irrigation with MACSF or
-
Frontiers | Case report: A cystic capillary hemangioma located at the conus medullaris mimicking hemangioblastoma Front. Neurol. (IF 3.4) Pub Date : 2024-03-19 Jiachen Sun, Jiuhong Li, Ziba Ayi, Feilong Yang, Junlin Hu, Xuhui Hui, Haifeng Chen, Jiaojiang He
Capillary hemangiomas, usually found in skin and mucosal tissues, are rarely encountered within the spinal cord, presenting a significant diagnostic challenge. We report a rare case of intradural extramedullary capillary hemangioma at the conus medullaris in a 66-year-old female patient. Our initial diagnosis leaned towards a cystic hemangioblastoma based on MRI findings due to the presence of cystic
-
Frontiers | Altered volume of the amygdala subregions in patients with chronic low back pain Front. Neurol. (IF 3.4) Pub Date : 2024-03-19 Si-Yu Gu, Feng-Chao Shi, Shu Wang, Cheng-Yu Wang, Xin-Xin Yao, Yi-Fan Sun, Jian-Bin Hu, Fei Chen, Ping-Lei Pan, Wen-Hui Li
Background Neuroimaging studies have suggested a pivotal role for the amygdala involvement in chronic low back pain (CLBP). However, the relationship between the amygdala subregions and CLBP has not yet been delineated. This study aimed to analyze whether the amygdala subregions were linked to the development of CLBP. Methods A total of 45 patients with CLBP and 45 healthy controls (HCs) were included