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Visual omitted stimulus potentials are not retinotopic Neurosci. Lett. (IF 2.5) Pub Date : 2024-04-15 Tomomi Ishida, Hiroshi Nittono
Omitted stimulus potentials (OSPs) are elicited in response to the omission of expected stimuli and are thought to reflect prediction errors. If prediction errors are signaled in the sensory cortex, OSPs are expected to be generated in the sensory cortex. The present study investigated the involvement of the early visual cortex in the generation of OSPs by testing whether omitted visual stimuli elicit
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Chronic corticosterone exposure in rats induces sex-specific alterations in hypothalamic reelin fragments, MeCP2, and DNMT3a protein levels Neurosci. Lett. (IF 2.5) Pub Date : 2024-04-13 Carla Liria Sánchez-Lafuente, Laura Martinez-Verbo, Jenessa N. Johnston, Jennifer Floyd, Manel Esteller, Lisa E. Kalynchuk, Juan Ausió, Hector J. Caruncho
Women are disproportionately affected by stress-related disorders like depression. In our prior research, we discovered that females exhibit lower basal hypothalamic reelin levels, and these levels are differentially influenced by chronic stress induced through repeated corticosterone (CORT) injections. Although epigenetic mechanisms involving DNA methylation and the formation of repressor complexes
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Study on the role and mechanism of Tan IIA in Alzheimer’s disease based on CREB-BDNF-TrkB pathway Neurosci. Lett. (IF 2.5) Pub Date : 2024-04-12 Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zhou
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Neural correlates of aggression outcome expectation and their association with aggression: A voxel-based morphometry study Neurosci. Lett. (IF 2.5) Pub Date : 2024-04-09 Xinyu Gong, Bohua Hu, Senrong Liao, Bingxin Qi, Liang Wang, Qinghua He, Ling-Xiang Xia
Aggression outcome expectation is an important cognitive factor of aggression. Discovering the neural mechanism of aggression outcome expectation is conducive to developing aggression research. However, the neural correlates underlying aggression outcome expectation and its effect remain elusive. We utilized voxel-based morphometry (VBM) to unravel the neural architecture of aggression outcome expectation
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Concussion can increase the risk of visually induced motion sickness Neurosci. Lett. (IF 2.5) Pub Date : 2024-04-08 Behrang Keshavarz, Meaghan S. Adams, Grace Gabriel, Lauren E. Sergio, Jennifer L. Campos
Concussion can lead to various symptoms such as balance problems, memory impairments, dizziness, and/or headaches. It has been previously suggested that during self-motion relevant tasks, individuals with concussion may rely heavily on visual information to compensate for potentially less reliable vestibular inputs and/or problems with multisensory integration. As such, concussed individuals may also
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Diagnostic value and cognitive regulatory roles of long non-coding RNA UCA1 in Alzheimer’s disease Neurosci. Lett. (IF 2.5) Pub Date : 2024-04-05 Yongjin Zhang, Fangping Wu
To explore the diagnostic role and potential mechanism of serum lncRNA UCA1 in Alzheimer's disease (AD). UCA1 concentration was determined using quantitative RT-PCR. The receiver operating characteristic curve was plotted to assess the diagnostic value. Cell viability and apoptotic capacity were assessed by cell counting kit-8 (CCK-8) and flow cytometry. Water maze experiments were used to test cognitive
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Does seasonal variation affect the neuroimmune system? A retrospective [11C]PBR28 PET study in healthy individuals Neurosci. Lett. (IF 2.5) Pub Date : 2024-04-05 Waleed Ibrahim, Jeonghyun An, Yanghong Yang, Kelly P. Cosgrove, David Matuskey
The neuroimmune system performs a wide range of functions in the brain and the central nervous system. The microglial translocator protein (TSPO) has an established role as a cell marker in identification of the neuroimmune system. Previously, human studies have shown TSPO differences in neuropsychiatric disorders. Seasonal variability has also been demonstrated in multiple systems of healthy individuals
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Unraveling the molecular landscape of Ataxia Telangiectasia: Insights into Neuroinflammation, immune dysfunction, and potential therapeutic target Neurosci. Lett. (IF 2.5) Pub Date : 2024-04-04 B.G. Sunila, T. Dhanushkumar, K.R. Dasegowda, Karthick Vasudevan, Majji Rambabu
Ataxia Telangiectasia (AT) is a genetic disorder characterized by compromised DNA repair, cerebellar degeneration, and immune dysfunction. Understanding the molecular mechanisms driving AT pathology is crucial for developing targeted therapies. In this study, we conducted a comprehensive analysis to elucidate the molecular mechanisms underlying AT pathology. Using publicly available RNA-seq datasets
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Hypothalamic TRPM8 and TRPA1 ion channel genes in the regulation of temperature homeostasis at water balance changes Neurosci. Lett. (IF 2.5) Pub Date : 2024-04-03 T.V. Kozyreva, I.V. Orlov, A.R. Boyarskaya, I.P. Voronova
The role of the hypothalamic cold-sensitive ion channels - transient receptor potential melastatin 8 (TRPM8) and transient receptor potential ankyrin 1 (TRPA1) in homeostatic systems of thermoregulation and water-salt balance – is not clear. The interaction of homeostatic systems of thermoregulation and water-salt balance without additional temperature load did not receive due attention, too. On the
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Creativity and humor in the elderly: Shared mechanisms and common functions to promote well-being Neurosci. Lett. (IF 2.5) Pub Date : 2024-04-03 Carlo Cristini, Laura Colautti, Annamaria Della Vedova, Alessandro Antonietti
In the paper the possible links between creative thinking and humor are sketched and their role in promoting well-being in the elderly is taken into account. The specific features of creative thinking in older people and its developmental trend in aging are outlined. The changes in humor which occur during aging are considered as well. The connections between creative thinking and humor are analysed
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Age-related reductions in whole brain mass and telencephalon volume in very old white Carneau pigeons (Columba livia) Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-29 Vincent J. Coppola, Holden R. Scribner, Caillie Barnett, Kaylyn A.S. Flanigan, Victoria R. Riesgo, Verner P. Bingman
While studies have identified age-related cognitive impairment in pigeons (Columba livia), no study has detected the brain atrophy which typically accompanies cognitive impairment in older mammals. Instead, Coppola and Bingman (Aging is associated with larger brain mass and volume in homing pigeons (Columba livia), Neurosci. Letters 698 (2019) 39–43) reported increased whole brain mass and telencephalon
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Involvement of primary somatosensory cortex in motor learning and task execution Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-28 Yunxuan Huang, Xiaoyu Zhang, Wei Li
The primary somatosensory cortex (S1) is responsible for processing information related to tactile stimulation, motor learning and control. Despite its significance, the connection between S1 and the primary motor cortex (M1), as well as its role in motor learning, remains a topic of ongoing exploration. In the present study, we silenced S1 by the GABA receptor agonist muscimol to study the potential
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Evaluation of the effect of Exercise Trainings and CGRP receptor antagonist (BIBN 4096) on mitochondrial dynamic in the hippocampus of male Wistar rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-27 Beydolah Shahouzehi, Yaser Masoumi-Ardakani, Hossein Fallah, Soheil Aminizadeh
Exercise training showed beneficial effects on brain. The purpose of the present study is to evaluate the effect of six weeks of high-intensity interval training (HIIT) and Endurance training (ET) with calcitonin gene-related peptide (CGRP) receptor antagonist on the expression of genes involved in mitochondrial dynamics and apoptosis in hippocampal tissue of male Wistar rats. In this study, forty-two
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Senescence and aging differentially alter key metabolic pathways in murine brain microglia Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-26 Milan R. Stojiljkovic, Christian Schmeer, Otto W. Witte
Microglia, the resident immune cells of the central nervous system, are critically involved in maintaining brain homeostasis. With age, microglia display morphological and functional alterations that have been associated with cognitive decline and neurodegeneration. Although microglia seem to participate in an increasing number of biological processes which require a high energy demand, little is known
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Azoles display promising anticonvulsant effects through possible PPAR-α activation Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-26 Suat Sari, Sibel Yurtoğlu, Merve Zengin, Monika Marcinkowska, Agata Siwek, Selma Saraç
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The impact of Dimethyl itaconate on c-Fos expression in the spinal cord in experimental pain models Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-21 Mohammad Abbaszadeh, Zohreh Ghotbeddin, Mohammad Reza Tabandeh, Kaveh Rahimi
Itaconate has been found to have potent anti-inflammatory effects and is being explored as a potential treatment for inflammatory diseases. However, its ability to relieve nociception and the mechanisms behind it are not yet understood. Our research aims to investigate the nociception-relieving properties of dimethyl itaconate (DMI) in the formalin test and writhing test. In male Wistar rats, Itaconic
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Individual differences in the neural representation of cooperation and competition Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-21 G.G. Knyazev, A.N. Savostyanov, A.V. Bocharov, A.E. Saprigyn
Much evidence links the Big Five’s agreeableness to a propensity for cooperation and aggressiveness to a propensity for competition. However, the neural basis for these associations is unknown. In this functional magnetic resonance imaging study, using multivariate pattern analysis of data recorded during a computer game in which participants were required to construct target patterns either in cooperation
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Effects of the designer drug 4-methylamphetamine on core temperature and serotonin levels in the striatum and hippocampus of rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-21 T. Lee Gilman, Jeremy R. Canfield, Travis J. Worst, Jon E. Sprague
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Effects of sleep deprivation and hazard types on the hazard perception of young novice drivers: An ERP study Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-21 Long Sun, Shan Liang, Shilong Yu, Jibo He
The present study aimed to explore the effects of sleep deprivation on young novice drivers’ cognitive neural processing of different hazard types. A 2 (sleep deprivation group, control group) × 3 (no hazard, covert hazard, overt hazard) mixed experimental design was used. Twenty-eight young drivers were sleep-deprived (no sleep within the past 24 h), while 28 drivers were in the control group (maintaining
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Extracranial transport of brain lymphatics via cranial nerve in human Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-20 Safiye Çavdar, Damlasu Altınöz, Tevriz Dilan Demir, İlke Ali Gürses, Gülnihal Özcan
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Effects of galvanic vestibular stimulation on postural righting reactions in hemiplegia Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-19 Akari Horikawa, Kazu Amimoto, Shota Horikawa, Ken Hiramoto, Masaki Nishio, Jun Yoshino, Yumi Ikeda
Patients with post-stroke hemiplegia often exhibit reduced ability to maintain sitting balance, a crucial factor for predicting prognosis. Galvanic vestibular stimulation (GVS) influences postural control by stimulating vestibular organ. Although several studies have focused on GVS in static postures, no studies have demonstrated the influence of GVS on righting reactions. Therefore, we aimed to investigate
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Reorganization of structural brain networks in Parkinson’s disease with postural instability/gait difficulty Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-19 Zihan Li, Jun Liu, Xinxin Miao, Shaoyun Ge, Jun Shen, Shaohua Jin, Zhengxue Gu, Yongfeng Jia, Kezhong Zhang, Jianwei Wang, Min Wang
The Postural Instability/Gait Difficulty (PIGD) subtype of Parkinson’s disease (PD) has a faster disease progression, a higher risk of cognitive and motor decline, yet the alterations of structural topological organization remain unknown.
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Affective disorders and the loudness dependence of the auditory evoked potential: Serotonin and beyond Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-17 Paul J. Fitzgerald
Identifying additional noninvasive biomarkers for affective disorders, such as unipolar major depressive disorder (MDD) and bipolar disorder (BD), could aid in the diagnosis and treatment of these prevalent and debilitating neuropsychiatric conditions. One such candidate biomarker is the loudness dependence of the auditory evoked potential (LDAEP), an event-related potential that measures responsiveness
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Why is there an error negativity on correct trials? A reappraisal Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-16 Céline Ramdani, Thierry Hasbroucq, Franck Vidal
In healthy subjects, the Error Negativity (Ne) was initially reported on errors and on partial errors, only. Later on, application of the Laplacian transformation to EEG data unmasked a Ne-like wave (Nc) that shares a main generator with the Ne, suggesting that the Nc is just a small Ne. However, the reason why a small Ne would persist on correct responses remains unclear. Now, sometimes, subthreshold
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Etomidate enhances cerebellar CF-PC synaptic plasticity through CB1 receptor/PKA cascade in vitro in mice Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-15 Guang-Gao Li, Ying-Han Xu, Ming-Ze Sun, Yan-Hua Bing, Wen-Zhe Jin, De-Lai Qiu
Etomidate (ET) is a widely used intravenous imidazole general anesthetic, which depresses the cerebellar neuronal activity by modulating various receptors activity and synaptic transmission. In this study, we investigated the effects of ET on the cerebellar climbing fiber-Purkinje cells (CF-PC) plasticity in vitro in mice using whole-cell recording technique and pharmacological methods. Our results
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Aerobic exercise suppresses cognitive injury in patients with Alzheimer’s disease by regulating long non-coding RNA TUG1 Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-14 Jiaojiao Chen, Caixia Su, Zhezhe Ma, Xiangling Ou, Minmin Zhan, Jiangbo Hu
Alzheimer’s disease (AD) is the primary reason for disability of the elderly. This article studied the diagnostic possibility of TUG1 and its potential mechanism in the regulation of aerobic exercise (AE) on AD. 77 AD patients undertook a three-month-long cycling exercise, and 77 healthy controls were recruited. Polymerase Chain Reaction amplification was applied to assess the expression of TUG1 and
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Senolytics prevent age-associated changes in female mice brain Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-12 Olivia Wyse Faria, Mayara Sandrielly Soares de Aguiar, Julia Eisenhardt de Mello, Fernando Lopez Alvez, Karina Pereira Luduvico, Driele Neske Garcia, Augusto Schneider, Michal M. Masternak, Roselia Maria Spanevello, Francieli Moro Stefanello
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Social isolation induces intestinal barrier disorder and imbalances gut microbiota in mice Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-11 Yue Wang, Hidayat Ullah, Ting Deng, Xinxiu Ren, Zinan Zhao, Yi Xin, Juanjuan Qiu
Social isolation, a known stressor, can have detrimental effects on both physical and mental health. Recent scientific attention has been drawn to the gut-brain axis, a bidirectional communication system between the central nervous system and gut microbiota, suggesting that gut microbes may influence brain function. This study aimed to explore the impact of social isolation on the intestinal barrier
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Developmental regulation of zinc homeostasis in differentiating oligodendrocytes Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-11 Christopher M. Elitt, Madeline M. Ross, Jianlin Wang, Christoph J. Fahrni, Paul A. Rosenberg
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Left prefrontal intermittent theta burst stimulation ameliorates tinnitus distress and symptoms of depression – A feasibility study Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-11 T. Hebel, M. Schecklmann, M.A. Abdelnaim, F.C. Weber, B. Langguth, S. Schoisswohl
Tinnitus remains a notoriously difficult to treat clinical entity. 1–2% of the entire population report relevant emotional distress due to tinnitus, and causal treatments are lacking. Repetitive transcranial magnetic stimulation (rTMS), most commonly of auditory cortical areas, has shown mixed results in the past. Prefrontal rTMS, including intermittent theta burst stimulation (iTBS) has shown more
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Boundary cap neural crest stem cells promote angiogenesis after transplantation to avulsed dorsal roots in mice and induce migration of endothelial cells in 3D printed scaffolds Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-11 Carl Trolle, Yilin Han, Shivaprakash Jagalur Mutt, Gustaf Christoffersson, Elena N. Kozlova
Dorsal root avulsion injuries lead to loss of sensation and to reorganization of blood vessels (BVs) in the injured area. The inability of injured sensory axons to re-enter the spinal cord results in permanent loss of sensation, and often also leads to the development of neuropathic pain. Approaches that restore connection between peripheral sensory axons and their CNS targets are thus urgently need
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Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-11 Guangzhao Shu, Yang He, Jin Suo, Chunhui Wu, Xudong Gong, Yangyang Xiang, Wenjiao Yang, Jiaxin Cheng, Yu Wang, Weiming Chen, Jingshan Shen
Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, has been confirmed to induce anxiolytic-like and antipsychotic-like effects. However, the exact mechanisms remain unclear. This study substantiated CBD's interaction with the 5-HT receptor (5-HTR) (CHO cells expressing human 5-HTR) and (rat lower lip retraction test, LLR test). We then assessed the impact of CBD in mice
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EEG correlates of trait test anxiety in the flanker task for adolescents Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-11 Hua Wei, Zhenni Jin
Adolescents face constant exams and often experience severe test anxiety. Previous studies suggested that test anxiety impairs individuals’ inhibitory control. Neurophysiological evidence suggests that anxiety interferes with the recruitment of the prefrontal region of the brain, which modulates top-down attentional control during the completion of inhibitory control tasks. However, there is little
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Central MOTS-c infusion affects reproductive hormones in obese and non-obese rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-08 Dilara Altay Ozturk (Öztürk), Yavuz Erden, Suat Tekin
MOTS-c, a mitochondrial-derived peptide, acts as a systemic hormone and MOTS-c level is inversely correlated with markers of obesity. Obesity is a risk factor for male reproductive physiology and is expressed as an important cause of infertility. In this study, we aimed to determine the effects of MOTS-c, which has been proven in the hypothalamus and testicles, on the actors involved in the reproductive
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Glycine transporter-1 inhibition by NFPS promotes neuroprotection against striatal damage models Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-07 Raul Izidoro Ribeiro, Gustavo Almeida Carvalho, Raphaela Almeida Chiareli, Isabel Vieira de Assis Lima, Paula Maria Quaglio Bellozi, Onésia Cristina Oliveira-Lima, Ágatha Oliveira Giacomelli, Alexander Birbrair, Renato Santiago Gomez, Antônio Carlos Pinheiro de Oliveira, Henning Ulrich, Mauro Cunha Xavier Pinto
The striatum, an essential component of the brain's motor and reward systems, plays a pivotal role in a wide array of cognitive processes. Its dysfunction is a hallmark of neurodegenerative diseases like Parkinson's disease (PD) and Huntington's disease (HD), leading to profound motor and cognitive deficits. These conditions are often related to excitotoxicity, primarily due to overactivation of NMDA
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Effects of anxiety state on N400 event-related brain potential response to unexpected semantic stimuli Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-07 Jennifer R. Lepock, Todd Girard, Justice Cupid, Michael Kiang
Emotional states can influence how people use meaningful context to make predictions about what comes next. To measure whether state anxiety influences such prediction, we used the N400 event-related brain potential (ERP) response to semantic stimuli, whose amplitude is smaller (less negative) when the stimulus is more predicted based on preceding context. Participants ( = 28) were randomized to one
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Corrigendum to “Evaluation of BCAS1-positive immature oligodendrocytes after cerebral ischemic stroke and SVD” [Neurosci. Lett. 812 (2023) 137405] Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-04 Guanhua Jiang, Takashi Ayaki, Takakuni Maki, Ken Yasuda, Daisuke Yoshii, Seiji Kaji, Ryosuke Takahashi
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Ameliorative effect of resveratrol on acute ocular hypertension induced retinal injury through the SIRT1/NF-κB pathway Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-04 Kai-bao Ji, Wei Wan, Yang Yang, Xue-jun He, Yi-qiao Xing, Zhe Hu
Glaucoma is a kind of neurodegenerative disorder characterized by irreversible loss of retinal ganglion cells (RGCs) and permanent visual impairment. It is reported that resveratrol (RES) is a promising drug for neurodegenerative diseases. However, the detailed molecular mechanisms underlying its protective potential have not yet been fully elucidated. The present study sought to investigate whether
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Blockage of metallothionein synthesis via adrenaline β receptor activation invalidates dehydroeffusol-mediated prevention of amyloid β1-42 toxicity Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-02 Haruna Tamano, Mako Takiguchi, Daichi Murakami, Yuya Kawano, Toshiyuki Fukuda, Hiroki Ikeda, Yasuhito Akagi, Shinji Ikeura, Atsushi Takeda
Dehydroeffusol, a major phenanthrene in , protects neurodegeneration induced by intracellular Zn ferried by extracellular amyloid β (Aβ). Here we focused on adrenaline β receptor activation and the induction of metallothioneins (MTs), intracellular Zn-binding proteins to test the protective mechanism of dehydroeffusol. Isoproterenol, an agonist of adrenergic β receptors elevated the level of MTs in
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Exogenous monosodium glutamate exacerbates lipopolysaccharide-induced neurobehavioral deficits, oxidative damage, neuroinflammation, and cholinergic dysfunction in rat brain Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-01 Folake Olubukola Asejeje, Michael Abayomi Abiola, Oluwatobi Adewumi Adeyemo, Olalekan Bukunmi Ogunro, Abayomi Mayowa Ajayi
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Repeated antibiotic drug treatment negatively affects memory function and glutamatergic nervous system of the hippocampus in mice Neurosci. Lett. (IF 2.5) Pub Date : 2024-03-01 Kohei Takahashi, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji
The gut microbiota is associated with memory; however, the relationship between dysbiosis-induced memory deficits and hippocampal glutamatergic neurons remains unclear. In our study, a mouse dysbiosis model showed impaired memory-related behavior in the passive avoidance test; decreased expression levels of glutaminase, excitatory amino acid transporter (EAAT)1, EAAT2, vesicular glutamate transporter
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Association of dopamine receptor D3 polymorphism with Levodopa-induced Dyskinesia: A study on Parkinson’s disease patients from India Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-29 Swagata Sarkar, Arindam Biswas, Sabbir Ansari, Supriyo Choudhury, Rebecca Banerjee, Suparna Chatterjee, Sanjit Dey, Hrishikesh Kumar
Levodopa-induced dyskinesia (LID) is a debilitating motor feature in a subset of patients with Parkinson’s disease (PD) after prolonged therapeutic administration of levodopa. Preliminary animal and human studies are suggestive of a key role of dopamine type 3 (D3) receptor polymorphism (Ser9Gly; rs6280) in LID. Its contribution to development of LID among Indian PD patients has remained relatively
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Chronic mild stress-induced dysregulation of MAPK and PI3K/AKT signaling in the hippocampus and medial prefrontal cortex of WKY female rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-29 Kristina Virijevic, Natasa Spasojevic, Bojana Stefanovic, Harisa Ferizovic, Milica Jankovic, Perica Vasiljevic, Sladjana Dronjak
Wistar-Kyoto (WKY) rats subjected to chronic mild stress (CMS) represent a valid model of treatment-resistant depression (TRD). Considering that depression is more prevalent in women than in men, in the present study, female rats were used. We investigated the effect of CMS on behavior and different factors involved in neuroinflammatory processes and neuroplasticity in the hippocampus and medial prefrontal
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Role of the intracerebroventricular injection of the visfatin and its interaction with neuropeptide Y and nitric systems on food intake in neonatal chicken Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-29 Morteza Hesari, Shahin Hassanpour, Morteza Zendehdel, Bita vazir
Visfatin play an essential role in the central regulation of appetite in birds. This study aimed to determine role of intracerebroventricular (ICV) injection of the visfatin on food intake and its possible interaction with neuropeptide Y (NPY) and nitric oxide system in neonatal broiler chicken. In experiment 1, neonatal chicken received ICV injection visfatin (1, 2 and 4 µg). In experiment 2, chicken
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Thermosensitive hydrogel containing ethosuximide-loaded multivesicular liposomes attenuates age-related hearing loss in C57BL/6J mice Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-28 Wei Li, Wenfang Sun, Guoming Zhang, Yi Lu, Chunfu Dai
Ethosuximide is the first drug reported to protect against age-related hearing loss, but its benefits are hampered by the pronounced side effects generated through systemic administration. We prepared a thermosensitive hydrogel containing ethosuximide-encapsulated multivesicular liposomes (ethosuximide-loaded MVLs-Gel) and evaluated its functional and histological effects on age-related hearing loss
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“Evaluation of neprilysin activity in Adipose-Derived stem cells from Alzheimer's disease patients” Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-28 Kazuo Shigematsu, Naoyuki Komori, Mitsuko Ideno, Hisakazu Yamagishi
The antibody drugs targeting β-amyloid in Alzheimer's disease pose risks of inflammation and vascular damage. It is known that neprilysin, an endogenous enzyme responsible for β-amyloid degradation, is reduced in areas with β-amyloid deposition. Supplementation of neprilysin could potentially contribute to Alzheimer’s disease treatment. When considering the use of adipose tissue-derived stem cells
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Value of serum brain-derived neurotrophic factor and glial fibrillary acidic protein for detecting depression in patients with Helicobacter pylori infection Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-24 En Zhao, Qian Yu, Meilei Wang, Zhengqiu Wang, Bin Jiang, Xiang Ma, Bin Zhou, Qingyong Dai, Jinyu Li, Shiming Wang, Fengjuan Chen, Xiaojun Yang
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Investigation of neuroprotective and therapeutic effects of cannabidiol in an acute coronary syndrome model Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-23 M. Dogan Unlu, D. Uysal, N.F. Karakuyu, S. Asci, O. Ozmen, M.Y. Tepebasi
The ischemia–reperfusion (I/R) injury seen in the heart can cause severe damage to essential organs such as the brain. Cannabidiol (CBD) obtained from Cannabis sativa is used today to treat various diseases. This study aimed to demonstrate CBD's neuroprotective and therapeutic properties in rats with brain damage caused by I/R in the heart. Rats were divided into four groups; sham, I/R, I/R + Prophylactic
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Overexpression of MTMR14 induced learning and memory impairments in 2-month-old C57 mice Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-23 Qiong Feng, Xiao Li, Ruijuan Liu, Gongping Liu, Ye He, Ting Li
Multiple biological functions of MTMR14 including regulation of autophagy, inflammation and Ca homeostasis have been reported. However, its functional contribution to learning and memory remains unclear. In this study, we investigated whether upregulation of MTMR14 induced cognitive impairment and the underlying mechanisms. MTMR14 level was significantly increased in cells or brain tissues that overexpressed
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Symmetry of synuclein density in autopsied Parkinson’s disease submandibular glands Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-21 Charles H. Adler, Geidy E. Serrano, Holly A. Shill, Erika Driver-Dunckley, Shyamal H. Mehta, Nan Zhang, Michael Glass, Lucia I. Sue, Anthony Intorcia, Thomas G. Beach
Peripheral tissue biopsy in Parkinson’s disease (PD) may be valuable for clinical care, biomarker validation, and as research enrollment criteria. Determine whether submandibular gland pathologic alpha-synuclein (aSyn) density is symmetrical and whether previous needle biopsy caused tissue damage. Thirty autopsy-confirmed PD cases having fixed submandibular gland tissue from one side and frozen submandibular
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Modulation of thioredoxin by chlorogenic acid in an ischemic stroke model and glutamate-exposed neurons Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-21 Ju-Bin Kang, Hyun-Kyoung Son, Dong-Ju Park, Yeung-Bae Jin, Fawad-Ali Shah, Phil-Ok Koh
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Novel neurodigital interface reduces motion sickness in virtual reality Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-19 Milivoj Dopsaj, Wilhelmina Tan, Vladimir Perovic, Zoran Stajic, Nemanja Milosavljevic, Slobodan Paessler, Tomoko Makishima
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TsMS combined with EA promotes functional recovery and axonal regeneration via mediating the miR-539-5p/Sema3A/PlexinA1 signalling axis in sciatic nerve-injured rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-18 Xianbin Wang, Shouxing Hu, Shuai Ouyang, Xiao Pan, Yingxue Fu, Xingyu Chen, Shuang Wu
Enhancing axonal regeneration is one of the most important processes in treating nerve injuries. Both magnetic and electrical stimulation have the effect of promoting nerve axon regeneration. But few study has investigated the effects of -spinal magnetic stimulation (TsMS) combined with electroacupuncture (EA) on nerve regeneration in rats with sciatic nerve injury. In this study, we compared the improvement
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Development of a novel tool to investigate human laughter behaviour and experience Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-17 Ceci Q. Cai, Marie A.E. Mueller, César F. Lima, Gulun Jin, Arabella Turek, Harri Sivasathiaseelan, Stella Guldner, Sophie K. Scott
We present a questionnaire exploring everyday laughter experience. We developed a 30-item questionnaire in English and collected data on an English-speaking sample ( = 823). Based on Principal Component Analysis (PCA), we identified four dimensions which accounted for variations in people’s experiences of laughter: laughter frequency (‘Frequency’), social usage of laughter (‘Usage’), understanding
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High-skilled first-person shooting game players have specific frontal lobe activity: Power spectrum analysis in an electroencephalogram study Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-16 Inhyeok Jeong, Naotsugu Kaneko, Ryogo Takahashi, Kimitaka Nakazawa
First-person shooting (FPS) games are among the most famous video games worldwide. However, cortical activities in environments related to real FPS games have not been studied. This study aimed to determine differences in cortical activity between low- and high-skilled FPS game players using 160-channel electroencephalography. Nine high-skilled FPS game players (official ranks: above the top 10%) and
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Altered connectivity between the central executive network and the salience network in delusion-prone individuals: A resting state eLORETA report Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-15 Margherita Filosa, Elena De Rossi, Giuseppe A. Carbone, Benedetto Farina, Chiara Massullo, Angelo Panno, Mauro Adenzato, Rita B. Ardito, Claudio Imperatori
Although the Triple Network (TN) model has been proposed as a valid neurophysiological framework for conceptualizing delusion-like experiences, the neurodynamics of TN in relation to delusion proneness have been relatively understudied in nonclinical samples so far. Therefore, the main aim of the current study was to investigate the functional connectivity of resting state electroencephalography (EEG)
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Continuous electrical stimulation of superior laryngeal nerve inhibits initiation of swallowing in anesthetized rats Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-14 Yuta Nakajima, Takanori Tsujimura, Kojun Tsuji, Jin Magara, Makoto Inoue
Pharyngeal electrical stimulation (PES) applies electrical stimulation to pharyngeal mucosa (PhM) and represents a useful approach to improve swallowing function in patients with dysphagia. To determine the optimal PES modality to treat dysphagia, the mechanism underlying the effects of PES on swallowing function must be elucidated. In this study, we evaluated how PES and electrical stimulation of
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GFAP-expressing cells in the adult hypothalamus can generate multiple neural cell lineages in vitro Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-13 Lucile Butruille, Martine Batailler, Pascal Vaudin, Delphine Pillon, Martine Migaud
Adult neural stem cells (NSCs) located in the two canonical neurogenic niches, the subventricular zone (SVZ) and the subgranular zone (SGZ), express the glial fibrillary acidic protein (GFAP). Recently, proliferative activity has been described in the hypothalamus although the characterization of hypothalamic neural stem/progenitor cells (NSPCs) is still uncertain. We therefore investigated whether
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Maternal aerobic exercise decreases the effects of a perinatal Western diet on the short and long-term memory of CD1 mouse progeny Neurosci. Lett. (IF 2.5) Pub Date : 2024-02-13 Minerva Ortiz-Valladares, Ricardo Pedraza-Medina, Salma Rosales-Herrera, Jorge Guzmán-Muñiz
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