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Moderate-Severe TBI as a Progressive Disorder: Patterns and Predictors of Cognitive Declines in the Chronic Stages of Injury. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-11-22 Robin E A Green,Marika K Dabek,Alana Changoor,Julia Rybkina,Georges A Monette,Brenda Colella
BACKGROUND Moderate-severe traumatic brain injury (TBI) has been associated with progressive cognitive decline in the chronic injury stages in a small number of studies. OBJECTIVE This study aimed to (i) replicate our previous findings of decline from 1 to 3+ years post-injury in a larger, non-overlapping sample and (ii) extend these findings by examining the proportion of decliners in 2 earlier time
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The Evolution of Hand Proprioceptive and Motor Impairments in the Sub-Acute Phase After Stroke. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-11-13 Monika Zbytniewska-Mégret,Christian Salzmann,Christoph M Kanzler,Thomas Hassa,Roger Gassert,Olivier Lambercy,Joachim Liepert
BACKGROUND Hand proprioception is essential for fine movements and therefore many activities of daily living. Although frequently impaired after stroke, it is unclear how hand proprioception evolves in the sub-acute phase and whether it follows a similar pattern of changes as motor impairments. OBJECTIVE This work investigates whether there is a corresponding pattern of changes over time in hand proprioception
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Access to Rehabilitation After Hospitalization for Traumatic Brain Injury: A National Longitudinal Cohort Study in Sweden. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-11-12 Andrea Klang,Yasmina Molero,Paul Lichtenstein,Henrik Larsson,Brian Matthew D'Onofrio,Niklas Marklund,Christian Oldenburg,Elham Rostami
BACKGROUND Rehabilitation is suggested to improve outcomes following traumatic brain injury (TBI), however, the extent of access to rehabilitation among TBI patients remains unclear. OBJECTIVE To examine the level of access to rehabilitation after TBI, and its association with health and sociodemographic factors. METHOD We conducted a longitudinal cohort study using Swedish nationwide healthcare and
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Applications of Repetitive Transcranial Magnetic Stimulation to Improve Upper Limb Motor Performance After Stroke: A Systematic Review. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-11-10 Afifa Safdar,Marie-Claire Smith,Winston D Byblow,Cathy M Stinear
BACKGROUND Noninvasive brain stimulation (NIBS) is a promising technique for improving upper limb motor performance post-stroke. Its application has been guided by the interhemispheric competition model and typically involves suppression of contralesional motor cortex. However, the bimodal balance recovery model prompts a more tailored application of NIBS based on ipsilesional corticomotor function
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Macrostructural Cerebellar Neuroplasticity Correlates With Motor Recovery After Stroke. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-10-26 Takashi Hanakawa,Fujiko Hotta,Tatsuhiro Nakamura,Keiichiro Shindo,Naoko Ushiba,Masaki Hirosawa,Yutaka Yamazaki,Yoshinao Moriyama,Syota Takagi,Katsuhiro Mizuno,Meigen Liu
BACKGROUND Motor recovery varies across post-stroke individuals, some of whom require a better rehabilitation strategy. We hypothesized that macrostructural neuroplasticity of the motor control network including the cerebellum might underlie individual differences in motor recovery. Objectives. To gain insight into the macrostructural neuroplasticity after stroke, we examined 52 post-stroke individuals
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Mild Stroke, Serious Problems: Limitations in Balance and Gait Capacity and the Impact on Fall Rate, and Physical Activity. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-10-25 Jolanda M B Roelofs,Sarah B Zandvliet,Ingrid M Schut,Anouk C M Huisinga,Alfred C Schouten,Henk T Hendricks,Digna de Kam,Leo A M Aerden,Johannes B J Bussmann,Alexander C H Geurts,Vivian Weerdesteyn
BACKGROUND After mild stroke persistent balance limitations may occur, creating a risk factor for fear of falling, falls, and reduced activity levels. Objective. To investigate whether individuals in the chronic phase after mild stroke show balance and gait limitations, elevated fall risk, reduced balance confidence, and physical activity levels compared to healthy controls. METHODS An observational
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Construct Validity of the Gait Deviation Index for People With Incomplete Spinal Cord Injury (GDI-SCI). Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-10-21 Isabel Sinovas-Alonso,Diana Herrera-Valenzuela,Ana de-Los-Reyes-Guzmán,Roberto Cano-de-la-Cuerda,Antonio J Del-Ama,Ángel Gil-Agudo
BACKGROUND The Gait Deviation Index for Spinal Cord Injury (SCI-GDI) was recently proposed as a dimensionless multivariate kinematic measure based on 21 gait features derived from 3-dimensional kinematic data which quantifies gait impairment of adult population with incomplete spinal cord injury (iSCI) relative to the normative gait of a healthy group. Nevertheless, no validity studies of the SCI-GDI
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A Systematic Review of the Learning Dynamics of Proprioception Training: Specificity, Acquisition, Retention, and Transfer. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-10-21 Han Gil Seo,Seo Jung Yun,Andria J Farrens,Christopher A Johnson,David J Reinkensmeyer
OBJECTIVE We aimed to identify key aspects of the learning dynamics of proprioception training including: 1) specificity to the training type, 2) acquisition of proprioceptive skills, 3) retention of learning effects, and 4) transfer to different proprioceptive skills. METHODS We performed a systematic literature search using the database (MEDLINE, EMBASE, Cochrane Library, and PEDro). The inclusion
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Free-Living Peak Cadence in Multiple Sclerosis: A New Measure of Real-World Walking? Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-10-21 Peixuan Zheng,Brenda Jeng,Trinh L T Huynh,Elroy J Aguiar,Robert W Motl
BACKGROUND Physical function and walking performance have become important outcomes in clinical trials and rehabilitation involving persons with multiple sclerosis (MS). However, assessments conducted in controlled settings may not reflect real-world capacity and movement in a natural environment. Peak cadence via accelerometry might represent a novel measure of walking intensity and prolonged natural
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Combined Reactive and Volitional Step Training Improves Balance Recovery and Stepping Reaction Time in People With Parkinson's Disease: A Randomised Controlled Trial. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-10-21 Paulo H S Pelicioni,Stephen R Lord,Jasmine C Menant,Carly Chaplin,Collen Canning,Matthew A Brodie,Daina L Sturnieks,Yoshiro Okubo
BACKGROUND Falls are frequent and devastating events for people with Parkinson's disease (PD). Here, we investigated whether laboratory-based reactive step training combined with home-based volitional step training was effective in improving balance recovery and stepping ability in people with PD. METHODS Forty-four people with idiopathic PD were randomized into intervention or control groups. Intervention
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Anti-Nogo-A Antibody Therapy Improves Functional Outcome Following Traumatic Brain Injury. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-10-14 Brian E Powers,Son T Ton,Robert G Farrer,Suhani Chaudhary,Russ P Nockels,Gwendolyn L Kartje,Shih-Yen Tsai
BACKGROUND Traumatic brain injury (TBI) can cause sensorimotor deficits, and recovery is slow and incomplete. There are no effective pharmacological treatments for recovery from TBI, but research indicates potential for anti-Nogo-A antibody (Ab) therapy. This Ab neutralizes Nogo-A, an endogenous transmembrane protein that inhibits neuronal plasticity and regeneration. OBJECTIVE We hypothesized that
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Visual Exploration While Walking With and Without Visual Cues in Parkinson's Disease: Freezer Versus Non-Freezer. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-09-29 Lisa Graham,Jordan Armitage,Rodrigo Vitorio,Julia Das,Gill Barry,Alan Godfrey,Claire McDonald,Richard Walker,Martina Mancini,Rosie Morris,Samuel Stuart
BACKGROUND Visual cues can improve gait in Parkinson's disease (PD), including those experiencing freezing of gait (FOG). However, responses are variable and underpinning mechanisms remain unclear. Visuo-cognitive processing (measured through visual exploration) has been implicated in cue response, but this has not been comprehensively examined. OBJECTIVE To examine visual exploration and gait with
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Effective Delivery of Vagus Nerve Stimulation Requires Many Stimulations Per Session and Many Sessions Per Week Over Many Weeks to Improve Recovery of Somatosensation. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-09-11 Andrea D Ruiz,Kaitlyn M Malley,Tanya T Danaphongse,Fatima N Ahmad,Clareth Mota Beltran,Robert L Rennaker,Michael P Kilgard,Seth A Hays
BACKGROUND Chronic sensory loss is a common and undertreated consequence of many forms of neurological injury. Emerging evidence indicates that vagus nerve stimulation (VNS) delivered during tactile rehabilitation promotes recovery of somatosensation. OBJECTIVE Here, we characterize the amount, intensity, frequency, and duration of VNS therapy paradigms to determine the optimal dosage for VNS-dependent
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Neuroplastic Changes Associated With Hybrid Exercise-Cognitive Training in Stroke Survivors With Mild Cognitive Decline: A Randomized Controlled Trial. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-09-01 Ting-Ting Yeh,Ku-Chou Chang,Jiun-Jie Wang,Wei-Che Lin,Ching-Yi Wu
BACKGROUND Exercise and cognitive training have been shown to induce neuroplastic changes and modulate cognitive function following stroke. However, it remains unclear whether hybridized exercise-cognitive training facilitates cortical activity and further influences cognitive function after stroke. OBJECTIVE The study aimed to investigate the effects of 2 hybridized exercise-cognitive trainings on
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Effects of an Acute High Intensity Exercise Bout on Retention of Explicit, Strategic Locomotor Learning in Individuals With Chronic Stroke. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-08-30 Elizabeth D Thompson,Soumya Bhat,Margaret A French,Susanne Morton,Ryan T Pohlig,Darcy S Reisman
BACKGROUND Exercise priming, pairing high intensity exercise with a motor learning task, improves retention of upper extremity tasks in individuals after stroke, but has shown no benefit to locomotor learning. This difference may relate to the type of learning studied. Upper extremity studies used explicit, strategic tasks; locomotor studies used implicit sensorimotor adaptation (split-belt treadmill)
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Children With Bilateral Cerebral Palsy Exhibit Bimanual Asymmetric Motor Deficits and EEG Evidence of Dominant Sensorimotor Hemisphere Overreliance During Reaching. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-08-29 Connor Phillips,Julia Kline,Christopher J Stanley,Thomas C Bulea,Diane L Damiano
BACKGROUND Reaching is a fundamental motor skill often impaired in cerebral palsy (CP). Studies on manual function, intervention, and underlying brain mechanisms largely focus on unilateral CP. This first electroencephalography (EEG) evaluation of reaching exclusively in bilateral CP aims to quantify and relate brain activation patterns to bimanual deficits in this population. METHODS A total of 15
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The Effect of Botulinum Toxin Type A Injection in the Rectus Femoris in Stroke Patients Walking With a Stiff Knee Gait: A Randomized Controlled Trial. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-08-29 Martin J B Tenniglo,Anand V Nene,Johan S Rietman,Jaap H Buurke,Erik C Prinsen
BACKGROUND Over activity of the rectus femoris is often cited as a main cause for stiff knee gait (SKG). Botulinum toxin (BoNT) can be used to reduce this over activity. Inconsistent results for the effect of BoNT injections were found in literature which can possibly be explained by the study design as these were uncontrolled or non-randomized studies. OBJECTIVE To conduct a randomized controlled
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Recovery of Quiet Standing Balance and Lower Limb Motor Impairment Early Poststroke: How Are They Related? Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-08-19 Jonas Schröder,Wim Saeys,Elissa Embrechts,Ann Hallemans,Laetitia Yperzeele,Steven Truijen,Gert Kwakkel
BACKGROUND Recovery of quiet standing balance early poststroke has been poorly investigated using repeated measurements. OBJECTIVE To investigate (1) the time course of steady-state balance in terms of postural stability and inter-limb symmetry, and (2) longitudinal associations with lower limb motor recovery in the first 3 months poststroke. METHODS Forty-eight hemiparetic subjects (age: 58.9 ± 16
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aBnormal motION capture In aCute Stroke (BIONICS): A Low-Cost Tele-Evaluation Tool for Automated Assessment of Upper Extremity Function in Stroke Patients. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-08-17 Syed A Zamin,Kaichen Tang,Emily A Stevens,Melissa Howard,Dorothea M Parker,Allyson Seals,Xiaoqian Jiang,Sean Savitz,Shayan Shams
BACKGROUND The incidence of stroke and stroke-related hemiparesis has been steadily increasing and is projected to become a serious social, financial, and physical burden on the aging population. Limited access to outpatient rehabilitation for these stroke survivors further deepens the healthcare issue and estranges the stroke patient demographic in rural areas. However, new advances in motion detection
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Individual Differences in Response to Transcranial Direct Current Stimulation With Language Therapy in Subacute Stroke. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-08-17 Melissa D Stockbridge,Jordan Elm,Abeba A Teklehaimanot,Christy Cassarly,Leigh-Ann Spell,Julius Fridriksson,Argye E Hillis
BACKGROUND Transcranial direct current stimulation (tDCS) can be used to improve post-stroke aphasia. However, given the mixed evidence for its efficacy, individual differences may moderate the relative benefit of this strategy. In planned exploratory subgroup analyses, we examined whether age, education, sex, brain-derived neurotrophic factor status, and baseline performance individually impacted
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Histone Deacetylase 3 Inhibition Ameliorates Microglia-Mediated Neuro-Inflammation Via the SIRT1/Nrf2 Pathway After Traumatic Spinal Cord Injury. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-07-28 Shoubo Chen,Jingfang Ye,Guozhong Wu,Jinnan Shi,Xiang Li,Xiangrong Chen,Wenhua Wu
BACKGROUND Microglial-induced inflammation plays a crucial role in the pathophysiological process of nervous system injury, however, still lacks effective therapeutic agents. Previously, we discovered that the inhibition of histone deacetylase 3 (HDAC3) exerts anti-inflammatory effects after traumatic spinal cord injury (SCI), whereas little is known about its underlying mechanism. Therefore, the present
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Sensitivity to Change and Responsiveness of the Upper Extremity Fugl-Meyer Assessment in Individuals With Moderate to Severe Acute Stroke. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-07-24 Baothy P Huynh,Julie A DiCarlo,Isha Vora,Jessica Ranford,Perman Gochyyev,David J Lin,Teresa J Kimberley
BACKGROUND The Fugl-Meyer Assessment-Upper Extremity (FMA-UE) is a widely used outcome measure for quantifying motor impairment in stroke recovery. Meaningful change (responsiveness) in the acute to subacute phase of stroke recovery has not been determined. OBJECTIVE Determine responsiveness and sensitivity to change of the FMA-UE from 1-week to 6-weeks (subacute) after stroke in individuals with moderate
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Motor Decision-Making as a Common Denominator in Motor Pathology and a Possible Rehabilitation Target. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-07-21 K Germanova,K Panidi,T Ivanov,P Novikov,G E Ivanova,A Villringer,V V Nikulin,M Nazarova
Despite the substantial progress in motor rehabilitation, patient involvement and motivation remain major challenges. They are typically addressed with communicational and environmental strategies, as well as with improved goal-setting procedures. Here we suggest a new research direction and framework involving Neuroeconomics principles to investigate the role of Motor Decision-Making (MDM) parameters
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A Randomized Clinical Trial to Evaluate a Digital Therapeutic to Enhance Gait Function in Individuals With Parkinson's Disease. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-07-19 Jay L Alberts,Ryan D Kaya,Amanda L Penko,Matthew Streicher,Eric M Zimmerman,Sara Davidson,Benjamin L Walter,Anson B Rosenfeldt
BACKGROUND Postural instability and gait dysfunction (PIGD) is a cardinal symptom of Parkinson's disease (PD) and is exacerbated under dual-task conditions. Dual-task training (DTT), enhances gait performance, however it is time and cost intensive. Digitizing DTT via the Dual-task Augmented Reality Treatment (DART) platform can expand the availability of an effective intervention to address PIGD. OBJECTIVE
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Altered Dynamic Resting State Functional Connectivity Associated With Somatosensory Impairments in the Upper Limb in the Early Sub-Acute Phase Post-Stroke. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-06-23 Nele De Bruyn,Anna K Bonkhoff,Leen Saenen,Liselot Thijs,Bea Essers,Kaat Alaerts,Geert Verheyden
BACKGROUND. Altered dynamic functional connectivity has been associated with motor impairments in the acute phase post-stroke. Its association with somatosensory impairments in the early sub-acute phase remains unexplored. OBJECTIVE. To investigate altered dynamic functional connectivity associated with somatosensory impairments in the early sub-acute phase post-stroke. METHODS. We collected resting
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Measuring Arm and Hand Joint Kinematics to Estimate Impairment During a Functional Reach and Grasp Task after Stroke. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-06-09 Preeya Khanna,Tomas Oppenheim,Adelyn Tu-Chan,Gary Abrams,Karunesh Ganguly
BACKGROUND Current approaches to characterizing deficits in upper limb movements after stroke typically focus either on changes in a functional measure, for example, how well a patient can complete a task, or changes in impairment, for example, isolated measurements of joint range of motion. However, there can be notable dissociations between static measures of impairment versus those of function.
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Cognitive Impairments After Stroke Do Not Attenuate Explicit Visuomotor Adaptation in Reaching and Savings With the Unaffected Arm. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-06-07 Reut Binyamin-Netser,Noy Goldhamer,Inbar Avni,Adva Ressel Zviely,Lior Shmuelof
BACKGROUND Accumulating evidence suggests that motor performance is affected by the cognitive control abilities of the subject. Performance in motor tasks in populations with cognitive deficits such as older adults and subjects with stroke is therefore expected to deteriorate. The goal of this study is to investigate the relationship between cognitive impairments and motor control and learning impairments
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Autonomous Control of Music to Retrain Walking After Stroke. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-06-05 Ashley N Collimore,Anna V Roto Cataldo,Ashlyn J Aiello,Regina Sloutsky,Karen J Hutchinson,Brian Harris,Terry Ellis,Louis N Awad
BACKGROUND Post-stroke care guidelines highlight continued rehabilitation as essential; however, many stroke survivors cannot participate in outpatient rehabilitation. Technological advances in wearable sensing, treatment algorithms, and care delivery interfaces have created new opportunities for high-efficacy rehabilitation interventions to be delivered autonomously in any setting (ie, clinic, community
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Grasp Analysis in the Home Environment as a Measure of Hand Function After Cervical Spinal Cord Injury. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-06-05 Mehdy Dousty,Andrea Bandini,Parvin Eftekhar,David J Fleet,José Zariffa
BACKGROUND Following a spinal cord injury, regaining hand function is a top priority. Current hand assessments are conducted in clinics, which may not fully represent real-world hand function. Grasp strategies used in the home environment are an important consideration when examining the impact of rehabilitation interventions. OBJECTIVE The main objective of this study is to investigate the relationship
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Understanding the Neuroplastic Effects of Auricular Vagus Nerve Stimulation in Animal Models of Stroke: A Systematic Review and Meta-Analysis. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-06-05 Paulo S de Melo,João Parente,Ingrid Rebello-Sanchez,Anna Marduy,Anna Carolyna Gianlorenco,Chi Kyung Kim,Hyuk Choi,Jae-Jun Song,Felipe Fregni
BACKGROUND Transauricular vagus nerve stimulation (taVNS) is being studied as a feasible intervention for stroke, but the mechanisms by which this non-invasive technique acts in the cortex are still broadly unknown. OBJECTIVES This study aimed to systematically review the current pre-clinical evidence in the auricular vagus nerve stimulation (aVNS) neuroplastic effects in stroke. METHODS We searched
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Does a Cognitive Network Contribute to Motor Recovery After Ischemic Stroke? Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-06-02 Jungsoo Lee,Yun-Hee Kim
BACKGROUND In stroke patients, preserved cognitive function plays a role in motor recovery, but there is insufficient evidence on the involved mechanisms. These mechanisms require investigation in the human brain, which is composed of large-scale functionally specialized networks. OBJECTIVE In this study, we investigated the role of cognition-related networks on upper extremity motor recovery using
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Structural Integrity of the Cerebellar Outflow Tract Predicts Long-Term Motor Function After Middle Cerebral Artery Ischemic Stroke. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-06-02 Yeun Jie Yoo,Seong Hoon Lim,Youngkook Kim,Joon-Sung Kim,Bo Young Hong,Mi-Jeong Yoon,Hanee Rim,Geun-Young Park
BACKGROUND The cerebellum plays a crucial role in functional movement by influencing sensorimotor coordination and learning. However, the effects of cortico-cerebellar connectivity on the recovery of upper extremity motor function after stroke have not been investigated. We hypothesized that the integrity of the cortico-cerebellar connections would be reduced in patients with a subacute middle cerebral
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Proportional Recovery After Stroke: Addressing Concerns Regarding Mathematical Coupling and Ceiling Effects. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-06-02 Benjamin Chong,Alan Wang,Cathy M Stinear
Baseline scores after stroke have long been known as a good predictor of post-stroke outcomes. Similarly, the extent of baseline impairment has been shown to strongly correlate with spontaneous recovery in the first 3 to 6 months after stroke, a principle known as proportional recovery. However, recent critiques have proposed that proportional recovery is confounded, most notably by mathematical coupling
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Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-06-02 Frederico Pieruccini-Faria,Benjamin Cornish,Malcolm Binns,Julia Fraser,Seyyed M H Haddad,Kelly Sunderland,Joel Ramirez,Derek Beaton,Donna Kwan,Allison A Dilliott,Christopher Scott,Yanina Sarquis-Adamson,Alanna Black,Karen Van Ooteghem,Leanne Casaubon,Dar Dowlatshahi,Ayman Hassan,Jennifer Mandzia,Demetrios Sahlas,Gustavo Saposnik,Brian Tan,Robert Hegele,Dennis Bulman,Mahdi Ghani,John Robinson,Ekaterina
BACKGROUND Acute change in gait speed while performing a mental task [dual-task gait cost (DTC)], and hyperintensity magnetic resonance imaging signals in white matter are both important disability predictors in older individuals with history of stroke (poststroke). It is still unclear, however, whether DTC is associated with overall hyperintensity volume from specific major brain regions in poststroke
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Special Issue: Novel Technologies for Recovery after Neurological Injuries. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-06-01 Steven Zeiler,Randolph J Nudo
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Motor Activated Auricular Vagus Nerve Stimulation as a Potential Neuromodulation Approach for Post-Stroke Motor Rehabilitation: A Pilot Study. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-05-20 Bashar W Badran,Xiaolong Peng,Brenna Baker-Vogel,Scott Hutchison,Patricia Finetto,Kelly Rishe,Andrew Fortune,Ellen Kitchens,Georgia H O'Leary,Abigail Short,Christian Finetto,Michelle L Woodbury,Steve Kautz
BACKGROUND Implanted vagus nerve stimulation (VNS), when synchronized with post-stroke motor rehabilitation improves conventional motor rehabilitation training. A non-invasive VNS method known as transcutaneous auricular vagus nerves stimulation (taVNS) has emerged, which may mimic the effects of implanted VNS. OBJECTIVE To determine whether taVNS paired with motor rehabilitation improves post-stroke
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Predicting Motor Outcomes Using Atlas-Based Voxel Features of Post-Stroke Neuroimaging: A Scoping Review Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-05-16 Ji-Hun Yoo, Benjamin Chong, Peter Alan Barber, Cathy Stinear, Alan Wang
BackgroundAtlas-based voxel features have the potential to aid motor outcome prognostication after stroke, but are seldom used in clinically feasible prediction models. This could be because neuroi...
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Brain Stimulation and Constraint Induced Movement Therapy in Children With Unilateral Cerebral Palsy: A Randomized Controlled Trial Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-05-11 Juhi Gupta, Sheffali Gulati, Upinder Pal Singh, Atin Kumar, Prashant Jauhari, Biswaroop Chakrabarty, Ravindra Mohan Pandey, Renu Bhatia, Suman Jain, Achal Srivastava
BackgroundThere is a crucial need to devise optimum rehabilitation programs for children with cerebral palsy (CP).ObjectiveThis study aimed to assess the feasibility, safety, and efficacy of combin...
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Does Exercise Attenuate Disease Progression in People With Parkinson’s Disease? A Systematic Review With Meta-Analyses Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-05-11 Jiecheng A Li, Marte B. Loevaas, Catherine Guan, Lina Goh, Natalie E. Allen, Margaret K. Y. Mak, Jinglei Lv, Serene S. Paul
IntroductionExercise has many benefits for people with Parkinson’s disease (PD) and has been suggested to modify PD progression, but robust evidence supporting this is lacking.ObjectiveThis systema...
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Effects of Neurofeedback on Cognitive Function, Productive Activity, and Quality of Life in Patients With Traumatic Brain Injury: A Randomized Controlled Trial Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-04-26 Pin-Yuan Chen, I-Chang Su, Chun-Ying Shih, Yen-Chun Liu, Yu-Kai Su, Li Wei, Hui-Tzung Luh, Hui-Chuan Huang, Pei-Shan Tsai, Yen-Chun Fan, Hsiao-Yean Chiu
BackgroundCognitive impairment is common in patients with traumatic brain injury (TBI). Studies that have examined the effectiveness of neurofeedback (NFB) on cognitive function following TBI have ...
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Effectiveness of Center of Pressure Trajectory as Anticipatory Postural Adjustment Measurement in Parkinson’s Disease With Freezing of Gait History Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-04-21 Chien-Feng Kung, Yun-Ru Lai, Wen-Chan Chiu, Chia-Yi Lien, Chih-Cheng Huang, Ben-Chung Cheng, Wei-Che Lin, Yueh-Sheng Chen, Chiun-Chieh Yu, Yi-Fang Chiang, Yan-Ru Guo, Yin-Hong Chen, Cheng-Hsien Lu
BackgroundEvidence showed that patients with Parkinson’s disease (PD) who have a history of freezing of gait (FOG) have hypometric anticipatory postural adjustment (APA) during gait initiation (GI)...
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Early Subacute White Matter Hyperintensities and Recovery of Language After Stroke Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-04-21 Veronika Vadinova, Aleksi J. Sihvonen, Kimberley L. Garden, Laura Ziraldo, Tracy Roxbury, Kate O’Brien, David A. Copland, Katie L. McMahon, Sonia L. E. Brownsett
BackgroundWhite matter hyperintensities (WMH) are considered to contribute to diminished brain reserve, negatively impacting on stroke recovery. While WMH identified in the chronic phase after stro...
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Effect of Robot-Assisted Gait Training on Multiple Sclerosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-04-20 Fu-An Yang, Chien-Lin Lin, Wan-Chien Huang, Hsun-Yi Wang, Chih-Wei Peng, Hung-Chou Chen
BackgroundIn recent meta-analyses, robot-assisted gait training for patients with multiple sclerosis (MS) have yielded limited clinical benefits compared with conventional overground gait training....
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Comparative Effectiveness of Combined and Single Neurostimulation and Traditional Dysphagia Therapies for Post-Stroke Dysphagia: A Network Meta-Analysis Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-04-20 Kondwani Joseph Banda, Ko-Chiu Wu, Hsiu-Ju Jen, Hsin Chu, Li-Chung Pien, Ruey Chen, Tso-Ying Lee, Sheng-Kai Lin, Shih-Han Hung, Kuei-Ru Chou
BackgroundComparative therapeutic benefits of combined and single neurostimulation therapies including neuromuscular electrical stimulation (NMES), pharyngeal electrical stimulation (PES), repetiti...
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Differential Associations of Mobility With Fronto-Striatal Integrity and Lesion Load in Older Adults With and Without Multiple Sclerosis Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-04-18 Mark E. Wagshul, Frederick W. Foley, Kapil Chaudhary, Michael L. Lipton, Robert W. Motl, Meltem Izzetoglu, Manuel E. Hernandez, Mary Ann Picone, Roee Holtzer
BackgroundMobility impairment is common in older persons with multiple sclerosis (MS), and further compounded by general age-related mobility decline but its underlying brain substrates are poorly ...
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Choice of Arm Use in Stroke Survivors is Largely Driven by the Energetic Cost of the Movement Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-04-17 Hien Nguyen, Thanh Phan, Reza Shadmehr, Sang Wook Lee
BackgroundThe decision of which arm to use to achieve a goal depends on energetic costs and performance abilities of each arm. Following a stroke, there is a reduction in the use of the more-impair...
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New Artificial Intelligence-Integrated Electromyography-Driven Robot Hand for Upper Extremity Rehabilitation of Patients With Stroke: A Randomized, Controlled Trial Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-04-11 Yuhei Murakami, Kaoru Honaga, Hidemi Kono, Koshiro Haruyama, Tomofumi Yamaguchi, Mami Tani, Reina Isayama, Tomokazu Takakura, Akira Tanuma, Kozo Hatori, Futoshi Wada, Toshiyuki Fujiwara
BackgroundAn artificial intelligence (AI)-integrated electromyography (EMG)-driven robot hand was devised for upper extremity (UE) rehabilitation. This robot detects patients’ intentions to perform...
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Walking Outcome After Traumatic Paraplegic Spinal Cord Injury: The Function of Which Myotomes Makes a Difference? Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-04-11 Adrian Cathomen, Doris Maier, Jiri Kriz, Rainer Abel, Frank Röhrich, Michael Baumberger, Giorgio Scivoletto, Norbert Weidner, Rüdiger Rupp, Catherine R. Jutzeler, John D. Steeves, Armin Curt, Marc Bolliger, EMSCI study group
BackgroundAccurate prediction of walking function after a traumatic spinal cord injury (SCI) is crucial for an appropriate tailoring and application of therapeutical interventions. Long-term outcom...
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Predictors of Discharge Destination After Stroke Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-04-11 Theresa Schrage, Götz Thomalla, Martin Härter, Lisa Lebherz, Hannes Appelbohm, David Leander Rimmele, Levente Kriston
BackgroundDetermining the discharge destination after acute stroke care is important to prevent long-term disabilities and improve cost efficiency.ObjectiveThe aim of this study was to investigate ...
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Advances in Stroke Recovery Scientific Conference 2023 Abstracts. Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-03-30
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Development of a Remote Version of the Graded Redefined Assessment of Strength, Sensation, and Prehension (GRASSP): Validity and Reliability Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-03-28 Stephanie Voss, Andrea Adighibe, Emily Sanders, David Aaby, Rachel Kravitt, Gina Clark, Kelly Breen, Alexander Barry, Gail F. Forrest, Steve C. Kirshblum, Monica A. Perez, Sukhvinder Kalsi-Ryan, Masha Kocherginsky, William Zev Rymer, Milap S. Sandhu
BackgroundThe Graded Redefined Assessment of Strength, Sensation, and Prehension (GRASSP V1.0) was developed in 2010 as a 3-domain assessment for upper extremity function after tetraplegia (domains...
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Effects of Intensive Versus Distributed Constraint-Induced Movement Therapy for Children With Unilateral Cerebral Palsy: A Quasi-Randomized Trial Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-03-28 Tien-Ni Wang, Kai-Jie Liang, Yi-Chia Liu, Jeng-Yi Shieh, Hao-Ling Chen
BackgroundPrevious studies have compared the effectiveness of constraint-induced movement therapy (CIMT) by different training doses. However, whether the dosing schedule, that is, intensive or dis...
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Cerebrospinal Fluid Pressure Dynamics as a Bedside Test in Traumatic Spinal Cord Injury to Assess Surgical Spinal Cord Decompression: Safety, Feasibility, and Proof-of-Concept Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-03-15 Najmeh Kheram, Andrea Boraschi, Nikolai Pfender, Susanne Friedl, Maria Rasenack, Benjamin Fritz, Vartan Kurtcuoglu, Martin Schubert, Armin Curt, Carl M. Zipser
BackgroundSufficient and timely spinal cord decompression is a critical surgical objective for neurological recovery in spinal cord injury (SCI). Residual cord compression may be associated with di...
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Validity of Novel Outcome Measures for Hand Function Performance After Stroke Using Egocentric Video Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-03-13 Meng-Fen Tsai, Rosalie H. Wang, José Zariffa
BackgroundEvaluating upper limb (UL) interventions after stroke calls for outcome measures that describe impact on daily life in the community. UL use ratio has been used to quantify the performanc...
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Exercise Therapy in Early Multiple Sclerosis Improves Physical Function But Not Cognition: Secondary Analyses From a Randomized Controlled Trial Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-03-10 Morten Riemenschneider, Lars G. Hvid, Thor Petersen, Egon Stenager, Ulrik Dalgas
BackgroundExercise positively affects multiple sclerosis (MS) symptoms, physiological systems, and potentially cognition. However, an uninvestigated “window of opportunity” exists for exercise ther...
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Telerehabilitation Initiated Early in Post-Stroke Recovery: A Feasibility Study Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-03-06 Dylan Edwards, Sapna Kumar, Lorie Brinkman, Isabel Cardoso Ferreira, Alberto Esquenazi, Tiffany Nguyen, Michael Su, Stephanie Stein, Jaun May, Allison Hendrix, Casey Finley, Emily Howard, Steven C. Cramer
BackgroundEnhanced neural plasticity early after stroke suggests the potential to improve outcomes with intensive rehabilitation therapy. Most patients do not get such therapy, however, due to limi...
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Effects of Exercise Training on the Phosphoproteomics of the Medial Prefrontal Cortex in Rats With Autism Spectrum Disorder Induced by Valproic Acid Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-03-01 Genghong Tu, Youli Guo, Ruoshi Xiao, Lianying Tang, Min Hu, Bagen Liao
BackgroundThe key neural pathological characteristics of autism spectrum disorder (ASD) include abnormal synaptic plasticity of the medial prefrontal cortex (mPFC). Exercise therapy is widely used ...
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Stroke Lesion Volume and Injury to Motor Cortex Output Determines Extent of Contralesional Motor Cortex Reorganization Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-02-14 Cathrin M. Buetefisch, Marc W. Haut, Kate P. Revill, Scott Shaeffer, Lauren Edwards, Deborah A. Barany, Samir R. Belagaje, Fadi Nahab, Neeta Shenvi, Kirk Easley
BackgroundAfter stroke, increases in contralesional primary motor cortex (M1CL) activity and excitability have been reported. In pre-clinical studies, M1CL reorganization is related to the extent o...
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A Systematic Review on the Effects of Acute Aerobic Exercise on Neurophysiological, Molecular, and Behavioral Measures in Chronic Stroke Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-01-26 Anjali Sivaramakrishnan, Sandeep K. Subramanian
BackgroundA single bout of aerobic exercise (AE) can produce changes in neurophysiological and behavioral measures in healthy individuals and those with stroke. However, the effects of AE-priming e...
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Gait-Adaptability Training in People With Hereditary Spastic Paraplegia: A Randomized Clinical Trial Neurorehabilit. Neural Repair (IF 4.2) Pub Date : 2023-01-25 Lotte van de Venis, Bart van de Warrenburg, Vivian Weerdesteyn, Alexander C. H. Geurts, Jorik Nonnekes
Background and objectivesIn people with hereditary spastic paraplegia (HSP), reduced gait adaptability is common and disabling. Gait impairments result from lower extremity spasticity, muscle weakn...