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Methylene blue and its potential in the treatment of traumatic brain injury, brain ischemia, and Alzheimer’s disease Rev. Neurosci. (IF 4.1) Pub Date : 2024-03-26 Nickolay K. Isaev, Elizaveta E. Genrikhs, Elena V. Stelmashook
Traumatic brain injury (TBI) and brain ischemia/reperfusion cause neurodegenerative processes that can continue after the acute stage with the development of severe brain atrophy with dementia. In this case, the long-term neurodegeneration of the brain is similar to the neurodegeneration characteristic of Alzheimer’s disease (AD) and is associated with the accumulation of beta amyloid and tau protein
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Research advancements on nerve guide conduits for nerve injury repair Rev. Neurosci. (IF 4.1) Pub Date : 2024-03-22 Shoushuai Wang, Xinggui Wen, Zheyuan Fan, Xiangdong Ding, Qianqian Wang, Zhongling Liu, Wei Yu
Peripheral nerve injury (PNI) is one of the most serious causes of disability and loss of work capacity of younger individuals. Although PNS has a certain degree of regeneration, there are still challenges like disordered growth, neuroma formation, and incomplete regeneration. Regarding the management of PNI, conventional methods such as surgery, pharmacotherapy, and rehabilitative therapy. Treatment
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Impact of carotid stenosis on the outcome of stroke patients submitted to reperfusion treatments: a narrative review Rev. Neurosci. (IF 4.1) Pub Date : 2024-03-09 Giovanna Viticchi, Lorenzo Falsetti, Claudia Altamura, Chiara Di Felice, Fabrizio Vernieri, Marco Bartolini, Mauro Silvestrini
Intravenous thrombolysis (IT) and mechanical thrombectomy (MD) are the two interventional approaches that have changed the outcome of patients with acute ischemic stroke (AIS). Ipsilateral and contralateral carotid stenosis (ICS, CCS) play an important role in regulating cerebral hemodynamics, both in chronic and acute situations such as AIS. Several studies have explored their role in the incidence
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The role of long noncoding RNAs in amyotrophic lateral sclerosis Rev. Neurosci. (IF 4.1) Pub Date : 2024-03-07 Darya Rajabi, Shaghayegh Khanmohammadi, Nima Rezaei
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with a poor prognosis leading to death. The diagnosis and treatment of ALS are inherently challenging due to its complex pathomechanism. Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides involved in different cellular processes, incisively gene expression. In recent years, more studies have been conducted
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Dendritic spines and their role in the pathogenesis of neurodevelopmental and neurological disorders Rev. Neurosci. (IF 4.1) Pub Date : 2024-03-05 Aisan Akhgari, Tanja Maria Michel, Manouchehr Seyedi Vafaee
Since Cajal introduced dendritic spines in the 19th century, they have attained considerable attention, especially in neuropsychiatric and neurologic disorders. Multiple roles of dendritic spine malfunction and pathology in the progression of various diseases have been reported. Thus, it is inevitable to consider these structures as new therapeutic targets for treating neuropsychiatric and neurologic
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Analysis of radiological features in patients with post-stroke depression and cognitive impairment Rev. Neurosci. (IF 4.1) Pub Date : 2024-02-28 Jun Mu, Jiayi Li
Post-stroke depression (PSD) and post-stroke cognitive impairment (PSCI) are common complications following a stroke, significantly impacting the quality of life and survival time of survivors. Currently, the comorbidity of PSCI and PSD is receiving increasing attention, as they share some common clinical characteristics, mechanisms, risk factors, radiological features, and treatment strategies. They
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Current potential pathogenic mechanisms of copper-zinc superoxide dismutase 1 (SOD1) in amyotrophic lateral sclerosis Rev. Neurosci. (IF 4.1) Pub Date : 2024-02-21 Xin-Xin Wang, Wen-Zhi Chen, Cheng Li, Ren-Shi Xu
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease which damages upper and lower motor neurons (UMN and LMN) innervating the muscles of the trunk, extremities, head, neck and face in cerebrum, brain stem and spinal cord, which results in the progressive weakness, atrophy and fasciculation of muscle innervated by the related UMN and LMN, accompanying with the pathological signs
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Mitochondria and MICOS – function and modeling Rev. Neurosci. (IF 4.1) Pub Date : 2024-02-19 Haym Benaroya
An extensive review is presented on mitochondrial structure and function, mitochondrial proteins, the outer and inner membranes, cristae, the role of F1FO-ATP synthase, the mitochondrial contact site and cristae organizing system (MICOS), the sorting and assembly machinery morphology and function, and phospholipids, in particular cardiolipin. Aspects of mitochondrial regulation under physiological
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“Brain–breath” interactions: respiration-timing–dependent impact on functional brain networks and beyond Rev. Neurosci. (IF 4.1) Pub Date : 2024-02-14 Nozomu H. Nakamura, Yoshitaka Oku, Masaki Fukunaga
Breathing is a natural daily action that one cannot do without, and it sensitively and intensely changes under various situations. What if this essential act of breathing can impact our overall well-being? Recent studies have demonstrated that breathing oscillations couple with higher brain functions, i.e., perception, motor actions, and cognition. Moreover, the timing of breathing, a phase transition
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In vivo C6 glioma models: an update and a guide toward a more effective preclinical evaluation of potential anti-glioblastoma drugs Rev. Neurosci. (IF 4.1) Pub Date : 2024-02-14 Safura Pournajaf, Nastaran Afsordeh, Mohammad Hossein Pourgholami
Glioblastoma multiform (GBM) is the most common primary brain tumor with a poor prognosis and few therapeutic choices. In vivo, tumor models are useful for enhancing knowledge of underlying GBM pathology and developing more effective therapies/agents at the preclinical level, as they recapitulate human brain tumors. The C6 glioma cell line has been one of the most widely used cell lines in neuro-oncology
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Inflammation and oxidative stress in epileptic children: from molecular mechanisms to clinical application of ketogenic diet Rev. Neurosci. (IF 4.1) Pub Date : 2024-02-13 Azam Ildarabadi, Seyedeh Nooshan Mir Mohammad Ali, Fatemeh Rahmani, Narjes Mosavari, Elham Pourbakhtyaran, Nima Rezaei
Childhood epilepsy affects up to 1 % of children. It has been shown that 30 % of patients are resistant to drug treatments, making further investigation of other potential treatment strategies necessary. One such approach is the ketogenic diet (KD) showing promising results and potential benefits beyond the use of current antiepileptic drugs. This study aims to investigate the effects of KD on inflammation
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Diagnostic machine learning applications on clinical populations using functional near infrared spectroscopy: a review Rev. Neurosci. (IF 4.1) Pub Date : 2024-02-03 Aykut Eken, Farhad Nassehi, Osman Eroğul
Functional near-infrared spectroscopy (fNIRS) and its interaction with machine learning (ML) is a popular research topic for the diagnostic classification of clinical disorders due to the lack of robust and objective biomarkers. This review provides an overview of research on psychiatric diseases by using fNIRS and ML. Article search was carried out and 45 studies were evaluated by considering their
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Empowering brain cancer diagnosis: harnessing artificial intelligence for advanced imaging insights Rev. Neurosci. (IF 4.1) Pub Date : 2024-01-30 Omar S. Al-Kadi, Roa’a Al-Emaryeen, Sara Al-Nahhas, Isra’a Almallahi, Ruba Braik, Waleed Mahafza
Artificial intelligence (AI) is increasingly being used in the medical field, specifically for brain cancer imaging. In this review, we explore how AI-powered medical imaging can impact the diagnosis, prognosis, and treatment of brain cancer. We discuss various AI techniques, including deep learning and causality learning, and their relevance. Additionally, we examine current applications that provide
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Diversity of amyloid beta peptide actions Rev. Neurosci. (IF 4.1) Pub Date : 2024-01-28 Sona Mardanyan, Svetlana Sharoyan, Alvard Antonyan
Fibril formation by amyloidogenic proteins and peptides is considered the cause of a number of incurable diseases. One of the most known amyloid diseases is Alzheimer’s disease (AD). Traditionally, amyloidogenic beta peptides Aβ40 and Aβ42 (Aβs) are considered as main causes of AD and the foremost targets in AD fight. The main efforts in pharmacology are aimed at reducing Aβs concentration to prevent
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Evolving frontiers: endovascular strategies for the treatment of delayed cerebral ischemia Rev. Neurosci. (IF 4.1) Pub Date : 2024-01-25 David-Dimitris Chlorogiannis, Athina-Maria Aloizou, Theodoros Mavridis, Jonathan Andreas Sänger, Anargyros Chlorogiannis, Nikolaos Madouros, Panagiotis Papanagiotou
Cerebral vasospasm and delayed cerebral ischemia represent a very challenging aspect of cerebrovascular pathophysiology, most commonly subarachnoid hemorrhage, with significantly high mortality if left untreated. Considerable advances have been made in medical treatment and prompt diagnosis, while newer endovascular modalities have recently been proposed for cases of resistant cerebral vasospasm. However
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Oxidative stress involvement in the molecular pathogenesis and progression of multiple sclerosis: a literature review Rev. Neurosci. (IF 4.1) Pub Date : 2024-01-01 Alfredo Sanabria-Castro, Alberto Alape-Girón, Marietta Flores-Díaz, Ann Echeverri-McCandless, Alexander Parajeles-Vindas
Multiple sclerosis (MS) is an autoimmune debilitating disease of the central nervous system caused by a mosaic of interactions between genetic predisposition and environmental factors. The pathological hallmarks of MS are chronic inflammation, demyelination, and neurodegeneration. Oxidative stress, a state of imbalance between the production of reactive species and antioxidant defense mechanisms, is
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Exploring the latest findings on endovascular treatments for giant aneurysms: a review Rev. Neurosci. (IF 4.1) Pub Date : 2023-12-30 David-Dimitris Chlorogiannis, Athina-Maria Aloizou, Anargyros Chlorogiannis, Nefeli Kosta, Jonathan Andreas Sänger, Achilles Chatziioannou, Panagiotis Papanagiotou
Giant intracranial aneurysms represent a very challenging aspect of aneurysmal pathophysiology with very high mortality and morbidity if left untreated. Their variety in clinical presentation (subarachnoid hemorrhage, cranial nerve palsy, etc.) and pathological and imaging properties (location, anatomy, presence of collateral circulation) pose serious questions regarding the best treatment option.
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Vestibular function is associated with immune inflammatory response Rev. Neurosci. (IF 4.1) Pub Date : 2023-12-30 Zhaohui Song, Yuchuan Ding, Nathan Sim, Ho Jun Yun, Jing Feng, Pan Gu, Xiaokun Geng
Association between vestibular function and immune inflammatory response has garnered increasing interest. Immune responses can lead to anatomical or functional alterations of the vestibular system, and inflammatory reactions may impair hearing and balance. Vestibular disorders comprise a variety of conditions, such as vestibular neuritis, benign paroxysmal positional vertigo, Meniere’s disease, vestibular
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Studying the Alzheimer’s disease continuum using EEG and fMRI in single-modality and multi-modality settings Rev. Neurosci. (IF 4.1) Pub Date : 2023-12-29 Jing Li, Xin Li, Futao Chen, Weiping Li, Jiu Chen, Bing Zhang
Alzheimer’s disease (AD) is a biological, clinical continuum that covers the preclinical, prodromal, and clinical phases of the disease. Early diagnosis and identification of the stages of Alzheimer’s disease (AD) are crucial in clinical practice. Ideally, biomarkers should reflect the underlying process (pathological or otherwise), be reproducible and non-invasive, and allow repeated measurements
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Escape from X-chromosome inactivation and sex differences in Alzheimer’s disease Rev. Neurosci. (IF 4.1) Pub Date : 2023-12-29 Qing-Hua Song, Ke-Xuan Zhao, Shuai Huang, Tong Chen, Ling He
Sex differences exist in the onset and progression of Alzheimer’s disease. Globally, women have a higher prevalence, while men with Alzheimer’s disease experience earlier mortality and more pronounced cognitive decline than women. The cause of sex differences in Alzheimer’s disease remains unclear. Accumulating evidence suggests the potential role of X-linked genetic factors in the sex difference of
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An overview of retinal light damage models for preclinical studies on age-related macular degeneration: identifying molecular hallmarks and therapeutic targets Rev. Neurosci. (IF 4.1) Pub Date : 2023-12-28 Carozza Giulia, Zerti Darin, Tisi Annamaria, Ciancaglini Marco, Maccarrone Mauro, Maccarone Rita
Age-related macular degeneration (AMD) is a complex, multifactorial disease leading to progressive and irreversible retinal degeneration, whose pathogenesis has not been fully elucidated yet. Due to the complexity and to the multiple features of the disease, many efforts have been made to develop animal models which faithfully reproduce the overall AMD hallmarks or that are able to mimic the different
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Hypoxic ischemic brain injury: animal models reveal new mechanisms of melatonin-mediated neuroprotection Rev. Neurosci. (IF 4.1) Pub Date : 2023-12-28 Serafina Perrone, Silvia Carloni, Valentina Giovanna Dell’Orto, Laura Filonzi, Virginia Beretta, Chiara Petrolini, Chiara Lembo, Giuseppe Buonocore, Susanna Esposito, Francesco Nonnis Marzano
Oxidative stress (OS) and inflammation play a key role in the development of hypoxic–ischemic (H–I) induced brain damage. Following H–I, rapid neuronal death occurs during the acute phase of inflammation, and activation of the oxidant–antioxidant system contributes to the brain damage by activated microglia. So far, in an animal model of perinatal H–I, it was showed that neuroprostanes are present
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The role of myelin in neurodegeneration: implications for drug targets and neuroprotection strategies Rev. Neurosci. (IF 4.1) Pub Date : 2023-11-20 Gabriella E. Parrilla, Vivek Gupta, Roshana Vander Wall, Akanksha Salkar, Devaraj Basavarajappa, Mehdi Mirzaei, Nitin Chitranshi, Stuart L. Graham, Yuyi You
Myelination of axons in the central nervous system offers numerous advantages, including decreased energy expenditure for signal transmission and enhanced signal speed. The myelin sheaths surrounding an axon consist of a multi-layered membrane that is formed by oligodendrocytes, while specific glycoproteins and lipids play various roles in this formation process. As beneficial as myelin can be, its
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Dominant mechanism in spinal cord injury-induced immunodeficiency syndrome (SCI-IDS): sympathetic hyperreflexia Rev. Neurosci. (IF 4.1) Pub Date : 2023-10-27 Ping Yang, Zhi-qun Bian, Zhen-bo Song, Cheng-ying Yang, Li Wang, Zhong-xiang Yao
Clinical studies have shown that individuals with spinal cord injury (SCI) are particularly susceptible to infectious diseases, resulting in a syndrome called SCI-induced immunodeficiency syndrome (SCI-IDS), which is the leading cause of death after SCI. It is believed that SCI-IDS is associated with exaggerated activation of sympathetic preganglionic neurons (SPNs). After SCI, disruption of bulbospinal
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Intracortical brain-computer interfaces for improved motor function: a systematic review Rev. Neurosci. (IF 4.1) Pub Date : 2023-10-17 Matthew W. Holt, Eric C. Robinson, Nathan A. Shlobin, Jacob T. Hanson, Ismail Bozkurt
In this systematic review, we address the status of intracortical brain-computer interfaces (iBCIs) applied to the motor cortex to improve function in patients with impaired motor ability. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 Guidelines for Systematic Reviews. Risk Of Bias In Non-randomized Studies – of Interventions (ROBINS-I) and
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Adult ADHD: it is old and new at the same time – what is it? Rev. Neurosci. (IF 4.1) Pub Date : 2023-10-10 Raly James Perez Custodio, Jan G. Hengstler, Jae Hoon Cheong, Hee Jin Kim, Edmund Wascher, Stephan Getzmann
Even though the number of studies aiming to improve comprehension of ADHD pathology has increased in recent years, there still is an urgent need for more effective studies, particularly in understanding adult ADHD, both at preclinical and clinical levels, due to the increasing evidence that adult ADHD is highly distinct and a different entity from childhood ADHD. This review paper outlines the symptoms
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Subjective, behavioral and neurobiological effects of cannabis and cannabinoids in social anxiety Rev. Neurosci. (IF 4.1) Pub Date : 2023-10-09 Bárbara dos Anjos Rosário, Jéssica Alves Lemes, Maria Paula de Lima, Daniel Araki Ribeiro, Milena de Barros Viana
Social anxiety disorder (SAD) is a debilitating disorder, characterized by fear and anxiety in social situations. Evidence suggests that the levels of SAD are rising, in particularly after the COVID-19 pandemic. Serotonin and noradrenaline reuptake inhibitors and cognitive-behavioral therapy are effective treatments for SAD. Nevertheless, a significant number of patients do not respond well to these
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Understanding visual processing of motion: completing the picture using experimentally driven computational models of MT Rev. Neurosci. (IF 4.1) Pub Date : 2023-09-19 Parvin Zarei Eskikand, David B. Grayden, Tatiana Kameneva, Anthony N. Burkitt, Michael R. Ibbotson
Computational modeling helps neuroscientists to integrate and explain experimental data obtained through neurophysiological and anatomical studies, thus providing a mechanism by which we can better understand and predict the principles of neural computation. Computational modeling of the neuronal pathways of the visual cortex has been successful in developing theories of biological motion processing
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Automated diagnosis of autism with artificial intelligence: State of the art Rev. Neurosci. (IF 4.1) Pub Date : 2023-09-07 Amir Valizadeh, Mana Moassefi, Amin Nakhostin-Ansari, Soheil Heidari Some’eh, Hossein Hosseini-Asl, Mehrnush Saghab Torbati, Reyhaneh Aghajani, Zahra Maleki Ghorbani, Iman Menbari-Oskouie, Faezeh Aghajani, Alireza Mirzamohamadi, Mohammad Ghafouri, Shahriar Faghani, Amir Hossein Memari
Autism spectrum disorder (ASD) represents a panel of conditions that begin during the developmental period and result in impairments of personal, social, academic, or occupational functioning. Early diagnosis is directly related to a better prognosis. Unfortunately, the diagnosis of ASD requires a long and exhausting subjective process. We aimed to review the state of the art for automated autism diagnosis
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Fine-tuning the circadian system with light treatment for Parkinson’s disease: an in-depth, critical review Rev. Neurosci. (IF 4.1) Pub Date : 2023-08-23 Gregory L. Willis, Stuart M. Armstrong
Late in the twentieth century, interest intensified regarding the involvement of the circadian system in the aetiology and treatment of Parkinson’s disease (PD). It has been envisaged that this approach might provide relief beyond the limited benefits and severe side effects achieved by dopamine (DA) replacement. In the first clinical article, published in 1996, polychromatic light was used to shift
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Peripheral inflammation is a potential etiological factor in Alzheimer’s disease Rev. Neurosci. (IF 4.1) Pub Date : 2023-08-21 Ziyuan Li, Hui Wang, Yafu Yin
Peripheral inflammation could constitute a risk factor for AD. This review summarizes the research related to peripheral inflammation that appears to have a relationship with Alzheimer’s disease. We find there are significant associations between AD and peripheral infection induced by various pathogens, including herpes simplex virus type 1, cytomegalovirus, Epstein-Barr virus, human immunodeficiency
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Pathogenesis underlying hexanucleotide repeat expansions in C9orf72 gene in amyotrophic lateral sclerosis Rev. Neurosci. (IF 4.1) Pub Date : 2023-08-01 Zhao Zhong Chong, Daniel L. Menkes, Nizar Souayah
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder. Mutations in C9orf72 and the resulting hexanucleotide repeat (GGGGCC) expansion (HRE) has been identified as a major cause of familial ALS, accounting for about 40 % of familial and 6 % of sporadic cases of ALS in Western patients. The pathological outcomes of HRE expansion in ALS have been recognized
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Involvement of microglia in chronic neuropathic pain associated with spinal cord injury – a systematic review Rev. Neurosci. (IF 4.1) Pub Date : 2023-07-25 David Ramos, Célia Duarte Cruz
In recent decade microglia have been found to have a central role in the development of chronic neuropathic pain after injury to the peripheral nervous system. It is widely accepted that peripheral nerve injury triggers microglial activation in the spinal cord, which contributes to heightened pain sensation and eventually chronic pain states. The contribution of microglia to chronic pain arising after
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Dietary inflammatory index and neuropsychiatric disorders Rev. Neurosci. (IF 4.1) Pub Date : 2023-07-17 Mahsa Golshani Nasab, Arash Heidari, Mohammadreza Sedighi, Narges Shakerian, Mona Mirbeyk, Amene Saghazadeh, Nima Rezaei
Neuropsychiatric disorders (NPDs) are considered a potential threat to mental health. Inflammation predominantly plays a role in the pathophysiology of NPDs. Dietary patterns are widely postulated to be involved in the physiological response to inflammation. This review aims to discuss the literature on how dietary inflammatory index (DII) is related to inflammation and, consequently, NPDs. After comprehensive
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Role of the basal ganglia in innate and learned behavioural sequences Rev. Neurosci. (IF 4.1) Pub Date : 2023-07-12 Natalia Favila, Kevin Gurney, Paul G. Overton
Integrating individual actions into coherent, organised behavioural units, a process called chunking, is a fundamental, evolutionarily conserved process that renders actions automatic. In vertebrates, evidence points to the basal ganglia – a complex network believed to be involved in action selection – as a key component of action sequence encoding, although the underlying mechanisms are only just
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A review of neuroimaging-based data-driven approach for Alzheimer’s disease heterogeneity analysis Rev. Neurosci. (IF 4.1) Pub Date : 2023-07-08 Lingyu Liu, Shen Sun, Wenjie Kang, Shuicai Wu, Lan Lin
Alzheimer’s disease (AD) is a complex form of dementia and due to its high phenotypic variability, its diagnosis and monitoring can be quite challenging. Biomarkers play a crucial role in AD diagnosis and monitoring, but interpreting these biomarkers can be problematic due to their spatial and temporal heterogeneity. Therefore, researchers are increasingly turning to imaging-based biomarkers that employ
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The brain serotonin system in autism Rev. Neurosci. (IF 4.1) Pub Date : 2023-07-07 Alexander Ya Rodnyy, Elena M. Kondaurova, Anton S. Tsybko, Nina K. Popova, Dmitry A. Kudlay, Vladimir S. Naumenko
Autism spectrum disorders (ASDs) are among the most common neurodevelopmental diseases. These disorders are characterized by lack of social interaction, by repetitive behavior, and often anxiety and learning disabilities. The brain serotonin (5-HT) system is known to be crucially implicated in a wide range of physiological functions and in the control of different kinds of normal and pathological behavior
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Transsulfuration pathway: a targeting neuromodulator in Parkinson’s disease Rev. Neurosci. (IF 4.1) Pub Date : 2023-07-06 Andrea Corona-Trejo, María E. Gonsebatt, Cristina Trejo-Solis, Victoria Campos-Peña, Laura Itzel Quintas-Granados, Edgar Yebrán Villegas-Vázquez, Octavio Daniel Reyes-Hernández, Vicente Jesús Hernández-Abad, Gabriela Figueroa-González, Daniela Silva-Adaya
The transsulfuration pathway (TSP) is a metabolic pathway involving sulfur transfer from homocysteine to cysteine. Transsulfuration pathway leads to many sulfur metabolites, principally glutathione, H2S, taurine, and cysteine. Key enzymes of the TSP, such as cystathionine β-synthase and cystathionine γ-lyase, are essential regulators at multiple levels in this pathway. TSP metabolites are implicated
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The role of pain modulation pathway and related brain regions in pain Rev. Neurosci. (IF 4.1) Pub Date : 2023-06-08 Dandan Yao, Yeru Chen, Gang Chen
Pain is a multifaceted process that encompasses unpleasant sensory and emotional experiences. The essence of the pain process is aversion, or perceived negative emotion. Central sensitization plays a significant role in initiating and perpetuating of chronic pain. Melzack proposed the concept of the “pain matrix”, in which brain regions associated with pain form an interconnected network, rather than
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Pathway specific interventions reveal the multiple roles of ventral hippocampus projections in cognitive functions Rev. Neurosci. (IF 4.1) Pub Date : 2023-05-16 Ioannis Bakoyiannis, Eva-Gunnel Ducourneau, Shauna L. Parkes, Guillaume Ferreira
Since the 1950s study of Scoville and Milner on the case H.M., the hippocampus has attracted neuroscientists’ attention. The hippocampus has been traditionally divided into dorsal and ventral parts, each of which projects to different brain structures and mediates various functions. Despite a predominant interest in its dorsal part in animal models, especially regarding episodic-like and spatial cognition
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Current status of Guillain–Barré syndrome (GBS) in China: a 10-year comprehensive overview Rev. Neurosci. (IF 4.1) Pub Date : 2023-05-05 Yanna Song, Xiaoxiao Zheng, Yong Fang, Shan Liu, Kangding Liu, Jie Zhu, Xiujuan Wu
Guillain–Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy; a disease involving the peripheral nervous system which is the most common cause of acute flaccid paralysis worldwide. So far, it is still lack of a comprehensive overview and understanding of the national epidemiological, clinical characteristics, and the risk factors of GBS in China, as well as differences between China
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Microbiota–gut–brain axis and related therapeutics in Alzheimer’s disease: prospects for multitherapy and inflammation control Rev. Neurosci. (IF 4.1) Pub Date : 2023-04-21 Jiahao Li, Feng Zhang, Li Zhao, Chunbo Dong
Alzheimer’s disease (AD) is the most common type of dementia in the elderly and causes neurodegeneration, leading to memory loss, behavioral disorder, and psychiatric impairment. One potential mechanism contributing to the pathogenesis of AD may be the imbalance in gut microbiota, local and systemic inflammation, and dysregulation of the microbiota–gut–brain axis (MGBA). Most of the AD drugs approved
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A review on the efficacy and safety of lipid-lowering drugs in neurodegenerative disease Rev. Neurosci. (IF 4.1) Pub Date : 2023-04-10 Arezoo Rajabian, Alice P. McCloskey, Tannaz Jamialahmadi, Seyed Adel Moallem, Amirhossein Sahebkar
There is a train of thought that lipid therapies may delay or limit the impact of neuronal loss and poor patient outcomes of neurodegenerative diseases (NDDs). A variety of medicines including lipid lowering modifiers (LLMs) are prescribed in NDDs. This paper summarizes the findings of clinical and observational trials including systematic reviews and meta-analyses relating to LLM use in NDDs published
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Efficient, continual, and generalized learning in the brain – neural mechanism of Mental Schema 2.0 – Rev. Neurosci. (IF 4.1) Pub Date : 2023-03-24 Takefumi Ohki, Naoto Kunii, Zenas C. Chao
There has been tremendous progress in artificial neural networks (ANNs) over the past decade; however, the gap between ANNs and the biological brain as a learning device remains large. With the goal of closing this gap, this paper reviews learning mechanisms in the brain by focusing on three important issues in ANN research: efficiency, continuity, and generalization. We first discuss the method by
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Paradoxical kinesia may no longer be a paradox waiting for 100 years to be unraveled Rev. Neurosci. (IF 4.1) Pub Date : 2023-03-18 Liana Melo-Thomas, Rainer K. W. Schwarting
Parkinson’s disease (PD) is a progressive neurodegenerative disorder mainly characterized by bradykinesia and akinesia. Interestingly, these motor disabilities can depend on the patient emotional state. Disabled PD patients remain able to produce normal motor responses in the context of urgent or externally driven situations or even when exposed to appetitive cues such as music. To describe this phenomenon
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A systematic review of the effects of transcranial photobiomodulation on brain activity in humans Rev. Neurosci. (IF 4.1) Pub Date : 2023-03-17 Marjorie Dole, Vincent Auboiroux, Lilia Langar, John Mitrofanis
In recent years, transcranial photobiomodulation (tPBM) has been developing as a promising method to protect and repair brain tissues against damages. The aim of our systematic review is to examine the results available in the literature concerning the efficacy of tPBM in changing brain activity in humans, either in healthy individuals, or in patients with neurological diseases. Four databases were
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Targeting the gut–microbiota–brain axis in irritable bowel disease to improve cognitive function – recent knowledge and emerging therapeutic opportunities Rev. Neurosci. (IF 4.1) Pub Date : 2023-02-09 Heyong Tang, Xiaoqi Chen, Shun Huang, Gang Yin, Xiyang Wang, Guoming Shen
The brain–gut axis forms a bidirectional communication system between the gastrointestinal (GI) tract and cognitive brain areas. Disturbances to this system in disease states such as inflammatory bowel disease have consequences for neuronal activity and subsequent cognitive function. The gut–microbiota–brain axis refers to the communication between gut-resident bacteria and the brain. This circuits
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A review of the application of three-dimensional convolutional neural networks for the diagnosis of Alzheimer’s disease using neuroimaging Rev. Neurosci. (IF 4.1) Pub Date : 2023-02-02 Xinze Xu, Lan Lin, Shen Sun, Shuicai Wu
Alzheimer’s disease (AD) is a degenerative disorder that leads to progressive, irreversible cognitive decline. To obtain an accurate and timely diagnosis and detect AD at an early stage, numerous approaches based on convolutional neural networks (CNNs) using neuroimaging data have been proposed. Because 3D CNNs can extract more spatial discrimination information than 2D CNNs, they have emerged as a
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Two-photon microscopy: application advantages and latest progress for in vivo imaging of neurons and blood vessels after ischemic stroke Rev. Neurosci. (IF 4.1) Pub Date : 2023-01-31 Jiarui Li, Xuan Wu, Yu Fu, Hao Nie, Zhouping Tang
Two-photon microscopy (TPM) plays an important role in the study of the changes of the two important components of neurovascular units (NVU) – neurons and blood vessels after ischemic stroke (IS). IS refers to sudden neurological dysfunction caused by focal cerebral ischemia, which is one of the leading causes of death and disability worldwide. TPM is a new and rapidly developing high-resolution real-time
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Targeting NMDA receptor signaling for therapeutic intervention in brain disorders Rev. Neurosci. (IF 4.1) Pub Date : 2022-12-31 He Chen, Yuanping Dong, Yun Wu, Feng Yi
N-Methyl-d-aspartate (NMDA) receptor hyperfunction plays a key role in the pathological processes of depression and neurodegenerative diseases, whereas NMDA receptor hypofunction is implicated in schizophrenia. Considerable efforts have been made to target NMDA receptor function for the therapeutic intervention in those brain disorders. In this mini-review, we first discuss ion flux-dependent NMDA
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Anticipatory attractors, functional neurochemistry and “Throw & Catch” mechanisms as illustrations of constructivism Rev. Neurosci. (IF 4.1) Pub Date : 2022-12-30 Irina Trofimova
This review explores several rarely discussed examples illustrating constructivism principles, generative and selective features of neuronal regulation of behaviour. First, the review highlights Walter Freeman’s experiments and mathematical analysis that uncovered the existence of anticipatory attractors, i.e. non-random dynamical patterns in neurodynamics. Since Freeman’s work did not extend to neurochemistry
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Ferroptosis: a potential therapeutic target for Alzheimer’s disease Rev. Neurosci. (IF 4.1) Pub Date : 2022-12-14 Lan Yang, Jianfei Nao
The most prevalent dementia-causing neurodegenerative condition is Alzheimer’s disease (AD). The aberrant buildup of amyloid β and tau hyperphosphorylation are the two most well-known theories about the mechanisms underlying AD development. However, a significant number of pharmacological clinical studies conducted around the world based on the two aforementioned theories have not shown promising outcomes
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Current advances in stem cell therapy in the treatment of multiple sclerosis Rev. Neurosci. (IF 4.1) Pub Date : 2022-12-11 Parnian Zolfaghari Baghbadorani, Amirmasoud Rayati Damavandi, Samira Moradi, Meysam Ahmadi, Peyman Bemani, Hamid Aria, Hossein Mottedayyen, Amirhossein Rayati Damavandi, Nahid Eskandari, Farshid Fathi
Multiple sclerosis (MS) is an inflammatory disease related to the central nervous system (CNS) with a significant global burden. In this illness, the immune system plays an essential role in its pathophysiology and progression. The currently available treatments are not recognized as curable options and, at best, might slow the progression of MS injuries to the CNS. However, stem cell treatment has
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Recent research progress on metabolic syndrome and risk of Parkinson’s disease Rev. Neurosci. (IF 4.1) Pub Date : 2022-11-30 Lin-yi Li, Shu-fen Liu, Jian-long Zhuang, Mi-mi Li, Zheng-ping Huang, Yan-hong Chen, Xiang-rong Chen, Chun-nuan Chen, Shu Lin, Li-chao Ye
Parkinson’s disease (PD) is one of the most widespread neurodegenerative diseases. PD is associated with progressive loss of substantia nigra dopaminergic neurons, including various motor symptoms (e.g., bradykinesia, rigidity, and resting tremor), as well as non-motor symptoms (e.g., cognitive impairment, constipation, fatigue, sleep disturbance, and depression). PD involves multiple biological processes
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Extracellular histones as damage-associated molecular patterns in neuroinflammatory responses Rev. Neurosci. (IF 4.1) Pub Date : 2022-11-11 Christy M. Richards, Seamus A. McRae, Athena L. Ranger, Andis Klegeris
The four core histones H2A, H2B, H3, H4, and the linker histone H1 primarily bind DNA and regulate gene expression within the nucleus. Evidence collected mainly from the peripheral tissues illustrates that histones can be released into the extracellular space by activated or damaged cells. In this article, we first summarize the innate immune-modulatory properties of extracellular histones and histone-containing
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An update to pain management after spinal cord injury: from pharmacology to circRNAs Rev. Neurosci. (IF 4.1) Pub Date : 2022-11-09 Graciela L. Mazzone, María F. Coronel, Miranda Mladinic, Cynthia Sámano
Neuropathic pain (NP) following a spinal cord injury (SCI) is often hard to control and therapies should be focused on the physical, psychological, behavioral, social, and environmental factors that may contribute to chronic sensory symptoms. Novel therapeutic treatments for NP management should be based on the combination of pharmacological and nonpharmacological options. Some of them are addressed
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Simulation of oscillatory dynamics induced by an approximation of grid cell output Rev. Neurosci. (IF 4.1) Pub Date : 2022-11-03 Roger D. Traub, Miles A. Whittington, Mark O. Cunningham
Grid cells, in entorhinal cortex (EC) and related structures, signal animal location relative to hexagonal tilings of 2D space. A number of modeling papers have addressed the question of how grid firing behaviors emerge using (for example) ideas borrowed from dynamical systems (attractors) or from coupled oscillator theory. Here we use a different approach: instead of asking how grid behavior emerges
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A systematic review of transcranial direct current stimulation on eye movements and associated psychological function Rev. Neurosci. (IF 4.1) Pub Date : 2022-10-31 Ashwin Subramaniam, Sicong Liu, Liam Lochhead, Lawrence Gregory Appelbaum
The last decades have seen a rise in the use of transcranial direct current stimulation (tDCS) approaches to modulate brain activity and associated behavior. Concurrently, eye tracking (ET) technology has improved to allow more precise quantitative measurement of gaze behavior, offering a window into the mechanisms of vision and cognition. When combined, tDCS and ET provide a powerful system to probe
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Dysfunctional microglia and tau pathology in Alzheimer’s disease Rev. Neurosci. (IF 4.1) Pub Date : 2022-10-27 Gunel Ayyubova
Extensive human studies and animal models show that chronic immune system stimulation involving microglia, inflammasome, complement activation, synthesis of cytokines, and reactive oxygen species exacerbates neurodegeneration in Alzheimer’s disease (AD) and other tauopathies. Abnormalities in tau, Aβ, and microglial activation are frequently observed in dementia patients and indicate that these elements
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A systematic review of the effect of photobiomodulation on the neuroinflammatory response in animal models of neurodegenerative diseases Rev. Neurosci. (IF 4.1) Pub Date : 2022-10-27 Kangzhe Xie, Hala El Khoury, John Mitrofanis, Paul J. Austin
This systematic review examines the effect of photobiomodulation (PBM), the application of red to near infrared light on body tissues, on the neuroinflammatory response and oxidative stress in animal models of neurodegenerative diseases. The research question and search protocol were prospectively registered on the PROSPERO database. Neurodegenerative diseases are becoming ever more prevalent in the