-
Deferasirox exerts anti-epileptic effects by improving brain iron homeostasis via regulation of ITPRIP Neurochem. Int. (IF 4.2) Pub Date : 2024-03-30 Xinhao Duan, Huifang Han, Jing Liu, Yu Qiu, Yi Wang, Xiaotian Wu, Hui Zhang, Zhen Zou, Jingfu Qiu, Chengzhi Chen, Fei Xiao, Xin Tian
-
The antidepressant effects of protein arginine methyltransferase 2 involve neuroinflammation Neurochem. Int. (IF 4.2) Pub Date : 2024-03-30 Shunfeng Liu, Bei Zhang, Haowei Guo, Zhanghua Ding, Wenhui Hou, Xiaoli Hu, Yuchu Wang, Wupeng Tan, Shouhong Zhou
Protein arginine methyltransferase (PRMT) 2 catalyzes the methylation of arginine residues in histones. Depression is associated with histone methylation; however, more comprehensive research is needed on how PRMT2 regulates depression. The present study aimed to investigate the effects and possible mechanism(s) of PRMT2 overexpression on depression-like behavior induced by chronic unpredictable mild
-
Sorbs2 regulates seizure activity by influencing AMPAR-mediated excitatory synaptic transmission in temporal lobe epilepsy Neurochem. Int. (IF 4.2) Pub Date : 2024-03-29 Yuenan Ban, Xiaolan Yang, Dandan Tan, Chen Gong, Yuan Gao, Jinxian Yuan, Yangmei Chen, You Wang, Tao Xu
Temporal lobe epilepsy (TLE), the most common type of drug-resistant epilepsy, severely affects quality of life. However, the underlying mechanism of TLE remains unclear and deserves further exploration. Sorbs2, a key synaptic regulatory protein, plays an important role in the regulation of synaptic transmission in the mammalian brain. In this study, we aimed to investigate the expression pattern of
-
Radiation-induced bystander effect on the brain after fractionated spinal cord irradiation of aging rats Neurochem. Int. (IF 4.2) Pub Date : 2024-03-29 Soňa Bálentová, Petra Hnilicová, Dagmar Kalenská, Eva Baranovičová, Peter Muríň, Eva Hajtmanová
We investigated the influence of the so-called bystander effect on metabolic and histopathological changes in the rat brain after fractionated spinal cord irradiation. The study was initiated with adult Wistar male rats = at the age of 9 months. The group designated to irradiation = ) and the age-matched control animals = were subjected to an initial measurement using proton magnetic resonance spectroscopy
-
Impact of Helicobacter pylori and metabolic syndrome on mast cell activation-related pathophysiology and neurodegeneration Neurochem. Int. (IF 4.2) Pub Date : 2024-03-18 Jannis Kountouras, Marina Boziki, Evangelos Kazakos, Paschalis Theotokis, Evangelia Kesidou, Maria Nella, Christos Bakirtzis, Eleni Karafoulidou, Elisabeth Vardaka, Maria C. Mouratidou, Foteini Kyrailidi, Maria Tzitiridou-Chatzopoulou, Eirini Orovou, Evaggelia Giartza-Taxidou, Georgia Deretzi, Nikolaos Grigoriadis, Michael Doulberis
Both () infection and metabolic syndrome (MetS) are highly prevalent worldwide. The emergence of relevant research suggesting a pathogenic linkage between infection and MetS-related cardio-cerebrovascular diseases and neurodegenerative disorders, particularly through mechanisms involving brain pericyte deficiency, hyperhomocysteinemia, hyperfibrinogenemia, elevated lipoprotein-a, galectin-3 overexpression
-
Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction Neurochem. Int. (IF 4.2) Pub Date : 2024-03-13 Kohei Takahashi, Minoru Tsuji, Osamu Nakagawasai, Soh Katsuyama, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Hiroshi Takeda, Takeshi Tadano
Impaired olfactory function may be associated with the development of psychiatric disorders such as depression and anxiety; however, knowledge on the mechanisms underlying psychiatric disorders is incomplete. A reversible model of olfactory dysfunction, zinc sulfate (ZnSO) nasal-treated mice, exhibit depression-like behavior accompanying olfactory dysfunction. Therefore, we investigated olfactory function
-
Comments on: ‘Trends and hotspots in research of traumatic brain injury from 2000 to 2022: A bibliometric study’, Neurochemistry International, 172, 105646 Neurochem. Int. (IF 4.2) Pub Date : 2024-03-13 Yuh-Shan Ho, Ali Ouchi
-
Role of GABAB receptors in cognition and EEG activity in aged APP and PS1 transgenic mice Neurochem. Int. (IF 4.2) Pub Date : 2024-03-13 Dong Yuan, Zheng Zhou, Meihui Song, Yunfan Zhang, Yunbin Zhang, Ping Ren, Zhuangfei Chen, Yu Fu
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Recent evidence suggests that gamma-aminobutyric acid B (GABA) receptor-mediated inhibition is a major contributor to AD pathobiology, and GABA receptors have been hypothesized to be a potential target for AD treatment. The aim of this study is to determine how GABA regulation alters cognitive function and brain activity
-
Answer to the comments by Ouchi et al. Neurochem. Int. (IF 4.2) Pub Date : 2024-03-12 Kai Zhao, Jin Lei
-
The avBNSTGABA–VTA and avBNSTGABA–DRN pathways are respectively involved in the regulation of anxiety-like behaviors in parkinsonian rats Neurochem. Int. (IF 4.2) Pub Date : 2024-03-06 Ruotong Li, Guoyi Tang, Jie Yang, Shasha Gao, Yixuan Wang, Xiang Wu, Yihua Bai, Jian Liu
The anteroventral bed nucleus of stria terminalis (avBNST) is a key brain region which involves negative emotional states, such as anxiety. The most neurons in the avBNST are GABAergic, and it sends GABAergic projections to the ventral tegmental area (VTA) and the dorsal raphe nucleus (DRN), respectively. The VTA and DRN contain dopaminergic and serotonergic cell groups in the midbrain which regulate
-
Binding of the monoacylglycerol lipase (MAGL) radiotracer [3H]T-401 in the rat brain after status epilepticus Neurochem. Int. (IF 4.2) Pub Date : 2024-03-05 Jens D. Mikkelsen, Sanjay S. Aripaka, Cansu B. Egilmez, Burcu A. Pazarlar
Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase considered a potential novel drug target for the treatment of CNS disorders including epilepsy. Here we examined MAGL levels in a rat model of epilepsy. Autoradiography has been used to validate the binding properties of the MAGL radiotracer, [H]T-401, in the rat brain, and to explore spatial and temporal changes in binding levels in a
-
Loss and microglia phagocytosis of synaptic proteins in frontotemporal lobar degeneration with TDP-43 proteinopathy Neurochem. Int. (IF 4.2) Pub Date : 2024-03-05 Ivan Ayala, Atousa Bahrami, Yuting Pan, Callen Spencer, Margaret E. Flanagan, M.-Marsel Mesulam, Tamar Gefen, Changiz Geula
Cortical synaptic loss has emerged as an early abnormality in Alzheimer's disease (AD) with a strong relationship to cognitive performance. However, the status of synapses in frontotemporal lobar degeneration (FTLD) has received meager experimental attention. The purpose of this study was to investigate changes in cortical synaptic proteins in FTLD with tar DNA binding protein-43 (TDP-43) proteinopathy
-
Glycerophospholipid dysregulation after traumatic brain injury Neurochem. Int. (IF 4.2) Pub Date : 2024-02-28 Chinmoy Sarkar, Marta M. Lipinski
Brain tissue is highly enriched in lipids, the majority of which are glycerophospholipids. Glycerophospholipids are the major constituents of cellular membranes and play an important role in maintaining integrity and function of cellular and subcellular structures. Any changes in glycerophospholipid homeostasis can adversely affect brain functions. Traumatic brain injury (TBI), an acquired injury caused
-
Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models Neurochem. Int. (IF 4.2) Pub Date : 2024-02-28 Ying He, Ruicheng Li, Yuxi Yu, Chusheng Huang, Zhiran Xu, Tianbao Wang, Ming Chen, Hongri Huang, Zhongquan Qi
-
Potential of the Blue Calm® food supplement in the treatment of alcohol withdrawal-induced anxiety in adult zebrafish (Danio rerio) Neurochem. Int. (IF 4.2) Pub Date : 2024-02-27 Luzia Débora S. Marques, Yatagan M. da Rocha, Gabriela A. do Nascimento, Sacha Aubrey A.R. Santos, Natália Chaves G. Vieira, Luiz Francisco Wemmenson G. Moura, Daniela R. Alves, Wildson Max B. da Silva, Selene Maia de Morais, Keciany A. de Oliveira, Larissa Morais R. da Silva, Kalina Kelma O. de Sousa, Antonio Eufrásio Vieira-Neto, Henrique Douglas Melo Coutinho, Adriana Rolim Campos, Francisco Ernani
Alcohol use disorder (AUD) is characterized by a set of behavioral, cognitive, nutritional, and physiological phenomena derived from the uncontrolled use of alcoholic beverages. There are cases in which AUD is associated with anxiety disorder, and when untreated, it requires careful pharmacotherapy. Blue Calm® (BC) is a food supplement indicated to aid restorative sleep, which has traces of medicinal
-
Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation Neurochem. Int. (IF 4.2) Pub Date : 2024-02-25 Tian-Ci Zhang, Yi-Can Lin, Ning-Ning Sun, Shan Liu, Wen-Zhu Hu, Yan Zhao, Xian-Hui Dong, Xiao-Ping He
Alzheimer's disease (AD) is a neurodegenerative disease that seriously threatens the quality of life of the elderly. Its pathogenesis has not yet been fully elucidated. Ferroptosis, a cell death caused by excessive accumulation of iron-dependent lipid peroxides, has been implicated in the pathogenesis of AD. Uncontrolled lipid peroxidation is the core process of ferroptosis, and inhibiting lipid peroxidation
-
Anticonvulsant effect of (±) citronellal possibly through the GABAergic and voltage-gated sodium channel receptor interaction pathways: In vivo and in silico studies Neurochem. Int. (IF 4.2) Pub Date : 2024-02-22 Raihan Chowdhury, Md. Shimul Bhuia, Md. Sakib Al Hasan, Siddique Akber Ansari, Irfan Aamer Ansari, Ana Pavla Almeida Diniz Gurgel, Henrique Douglas Melo Coutinho, Muhammad Torequl Islam
This study aimed to investigate the anticonvulsant effects of citronellal (CIT) and possible underlying mechanisms through an isoniazid (INH)-induced seizure (convulsion) via and studies. For this, convulsions were induced by the oral administration of INH (300 mg/kg) to the mice. The animals were treated orally with different doses of CIT (50, 100, and 200 mg/kg). Vehicle served as a negative control
-
Inhibition of piezo1 prevents chronic cerebral hypoperfusion-induced cognitive impairment and blood brain barrier disruption Neurochem. Int. (IF 4.2) Pub Date : 2024-02-22 Fei Xu, Qing Xin, Mengyao Ren, Peixin Shi, Bing Wang
Chronic cerebral hypoperfusion (CCH) plays a critical role in the onset and progression of vascular dementia (VD), which is now recognized as the second most common form of dementia after Alzheimer's disease (AD). The mechanosensitive piezo1 channel has been identified to play important roles in several neurological disorders. However, the roles and possible mechanisms of piezo1 in CCH-induced cognitive
-
Factors promoting the release of picrotoxin from the trap in the GABA(A) receptor pore Neurochem. Int. (IF 4.2) Pub Date : 2024-02-21 Julia V. Bukanova, Elena I. Solntseva, Vladimir G. Skrebitsky
Picrotoxin (PTX), a convulsant of plant origin, has been used in many studies as research tool. PTX is the open channel blocker of the GABA receptor (GABAR). Being in the pore, PTX initiates transfer of the channel to the closed state and thus it falls into the “trap”. The consequence of this PTX trapping is so-called aftereffect, i.e. continuation of the blockade of the GABA-induced chloride current
-
Current advances in rodent drug-resistant temporal lobe epilepsy models: Hints from laboratory studies Neurochem. Int. (IF 4.2) Pub Date : 2024-02-19 Shuo Zhang, Shengyang Xie, Yang Zheng, Zhong Chen, Cenglin Xu
Anti-seizure drugs (ASDs) are the first choice for the treatment of epilepsy, but there is still one-third of patients with epilepsy (PWEs) who are resistant to two or more appropriately chosen ASDs, named drug-resistant epilepsy (DRE). Temporal lobe epilepsy (TLE), a common type of epilepsy usually associated with hippocampal sclerosis (HS), shares the highest proportion of drug resistance (approximately
-
The expression system influences stability, maturation efficiency, and oligomeric properties of the potassium-chloride co-transporter KCC2 Neurochem. Int. (IF 4.2) Pub Date : 2024-02-17 Morgan Kok, Karen Hartnett-Scott, Cassandra L. Happe, Matthew L. MacDonald, Elias Aizenman, Jeffrey L. Brodsky
The neuron-specific K/Cl co-transporter-2, KCC2, which is critical for brain development, regulates γ-aminobutyric acid-dependent inhibitory neurotransmission. Consistent with its function, mutations in KCC2 are linked to neurodevelopmental disorders, including epilepsy, schizophrenia, and autism. KCC2 possesses 12 transmembrane spans and forms an intertwined dimer. Based on its complex architecture
-
A novel combination approach to effectively reduce inflammation and neurodegeneration in multiple sclerosis models Neurochem. Int. (IF 4.2) Pub Date : 2024-02-15 Azizul Haque, Nicole N.M. Trager, Jonathan T. Butler, Arabinda Das, Vandana Zaman, Naren L. Banik
Multiple sclerosis (MS) is an autoimmune disease characterized by immune-mediated attacks on the central nervous system (CNS), resulting in demyelination and recurring T-cell responses.
-
α-Viniferin, a dietary phytochemical, inhibits Monoamine oxidase and alleviates Parkinson's disease associated behavioral deficits in a mice model Neurochem. Int. (IF 4.2) Pub Date : 2024-02-15 Chayan Banerjee, Raju Barman, Priya Darshani, Meghana Pillai, Sanchi Ahuja, Rupsha Mondal, V.S. Pragadheesh, Joy Chakraborty, Deepak Kumar
Parkinson's disease (PD) is one of the most prevalent age-related neurodegenerative disorders. Behavioral complexities worsen over time due to progressive dopaminergic (DArgic) neuronal loss at region of brain. Available treatments typically aim to increase dopamine (DA) levels at striatum. DA is degraded by Monoamine oxidase (MAO), thus dietary phytochemicals with MAO inhibitory properties can contribute
-
Brain region changes following a spinal cord injury Neurochem. Int. (IF 4.2) Pub Date : 2024-02-12 Zhiwu Wu, Kaiming Feng, Jinqing Huang, Xinyun Ye, Ruijin Yang, Qianliang Huang, Qiuhua Jiang
Brain-related complications are common in clinical practice after spinal cord injury (SCI); however, the molecular mechanisms of these complications are still unclear. Here, we reviewed the changes in the brain regions caused by SCI from three perspectives: imaging, molecular analysis, and electrophysiology. Imaging studies revealed abnormal functional connectivity, gray matter volume atrophy, and
-
Oxidative stress and mitochondrial dysfunction in brain of vinclozolin exposed animals Neurochem. Int. (IF 4.2) Pub Date : 2024-02-09 Livia Interdonato, Ylenia Marino, Ramona D'Amico, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Enrico Gugliandolo, Gianluca Antonio Franco, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Vinclozolin (VCZ) is a widely used fungicide in agriculture, especially in fruits and wine. Various studies have detailed the effects of VCZ exposure on different organs, but no information is available on its effects on brain tissues. This paper investigated the effects of VCZ exposure on the oxidative stress and mitochondrial dysfunction in brain tissue. C57BL/6 mice were exposed to VCZ (100 mg/kg)
-
STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway Neurochem. Int. (IF 4.2) Pub Date : 2024-02-08 XiaoLei Zhang, Yu Wang, Jia Lv
Oxidative stress and neuroinflammation are proven to play critical roles in the pathogenesis of Parkinson's disease (PD). As reported, patients with PD have lower level of STAT4 compared with healthy subjects. However, the biological functions and mechanisms of STAT4 in PD pathogenesis remain uncertain. This study aimed to investigate the roles and related mechanisms of STAT4 in PD development. The
-
Echinatin protects from ischemic brain injury by attenuating NLRP3-related neuroinflammation Neurochem. Int. (IF 4.2) Pub Date : 2024-02-07 Liang Sun, Duo Chen, Chenchen Zhao, Yujie Hu, Yuhao Xu, Shengnan Xia, Haiyan Yang, Xinyu Bao, Zhi Zhang, Chao Zhou, Qingxiu Zhang, Yun Xu
-
-
The role of mitochondrial uncoupling in the regulation of mitostasis after traumatic brain injury Neurochem. Int. (IF 4.2) Pub Date : 2024-02-03 W. Brad Hubbard, Gopal V. Velmurugan, Patrick G. Sullivan
Mitostasis, the maintenance of healthy mitochondria, plays a critical role in brain health. The brain's high energy demands and reliance on mitochondria for energy production make mitostasis vital for neuronal function. Traumatic brain injury (TBI) disrupts mitochondrial homeostasis, leading to secondary cellular damage, neuronal degeneration, and cognitive deficits. Mild mitochondrial uncoupling,
-
H2S inhibits LiCl/pilocarpine-induced seizures and promotes neuroprotection by regulating TRPV2 expression via the AC3/cAMP/PKA pathway Neurochem. Int. (IF 4.2) Pub Date : 2024-01-28 Jigao Feng, Shenghua Zhuo, Dayuan Liu, Hao Peng, Dachuang Guo, Ning Li, Hu Sun, Caicai Zhang, Jiannong Zhao
-
Early chronic fasudil treatment rescues hippocampal alterations in the Ts65Dn model for down syndrome Neurochem. Int. (IF 4.2) Pub Date : 2024-02-02 Rosa López-Hidalgo, Raúl Ballestín, Lorena Lorenzo, Sandra Sánchez-Martí, José Miguel Blasco-Ibáñez, Carlos Crespo, Juan Nacher, Emilio Varea
Down syndrome (DS) is the most common genetic disorder associated with intellectual disability. To study this syndrome, several mouse models have been developed. Among the most common is the Ts65Dn model, which mimics most of the alterations observed in DS. Ts65Dn mice, as humans with DS, show defects in the structure, density, and distribution of dendritic spines in the cerebral cortex and hippocampus
-
Supplementation of probiotic Bifidobacterium breve Bif11 reverses neurobehavioural deficits, inflammatory changes and oxidative stress in Parkinson's disease model Neurochem. Int. (IF 4.2) Pub Date : 2024-02-02 Sonali Valvaikar, Bhupesh Vaidya, Shikha Sharma, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Shyam S. Sharma
Human gut microbiota are thought to affect different physiological processes in the body, including brain functions. Gut dysbiosis has been linked to the progression of Parkinson's disease (PD) and thus, restoring the healthy gut microbiota with supplementation of putative probiotic strains can confer some benefits in PD. In the current study, we explored the neuroprotective potential of Bif11 supplementation
-
Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice Neurochem. Int. (IF 4.2) Pub Date : 2024-02-01 Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yabe
The serotonergic (5-HTergic) system is closely involved in the pathophysiology of mood and anxiety disorders and the responsibility of this system may differ for each symptom. In this study, we examined the relationship between the dysfunction of the 5-HTergic system and abnormal behaviors in the social defeat stress model, an animal model of mood and anxiety disorders and in mice with knockdown of
-
Age-related impact of social isolation in mice: Young vs middle-aged Neurochem. Int. (IF 4.2) Pub Date : 2024-01-23 Daniela M. Magalhães, Myrthe Mampay, Ana M. Sebastião, Graham K. Sheridan, Cláudia A. Valente
Social isolation is a chronic mild stressor and a significant risk factor for mental health disorders. Herein we explored the impact of social isolation on depression- and anxiety-like behaviours, as well as spatial memory impairments, in middle-aged male mice compared to post-weaning mice. We aimed to quantify and correlate social isolation-induced behaviour discrepancies with changes in hippocampal
-
How is the P2X7 receptor signaling pathway involved in epileptogenesis? Neurochem. Int. (IF 4.2) Pub Date : 2024-01-10 Caichuan Wei, Miaoying Fu, Haiju Zhang, Baozhen Yao
Epilepsy, a condition characterized by spontaneous recurrent epileptic seizures, is among the most prevalent neurological disorders. This disorder is estimated to affect approximately 70 million people worldwide. Although antiseizure medications are considered the first-line treatments for epilepsy, most of the available antiepileptic drugs are not effective in nearly one-third of patients. This calls
-
M2 muscarinic receptors negatively modulate cell migration in human glioblastoma cells Neurochem. Int. (IF 4.2) Pub Date : 2024-01-05 Claudia Guerriero, Rachele Fanfarillo, Patrizia Mancini, Valentina Sterbini, Giulia Guarguaglini, Luigi Sforna, Antonio Michelucci, Luigi Catacuzzeno, Ada Maria Tata
Glioblastoma (GB) is a very aggressive human brain tumor. The high growth potential and invasiveness make this tumor surgically and pharmacologically untreatable. Our previous work demonstrated that the activation of the M2 muscarinic acetylcholine receptors (M2 mAChRs) inhibited cell proliferation and survival in GB cell lines and in the cancer stem cells derived from human biopsies. The aim of the
-
M2a macrophages regulate fibrosis and affect the outcome after stroke via PU.1/mTOR pathway in fibroblasts Neurochem. Int. (IF 4.2) Pub Date : 2024-01-04 Jiagui Huang, Yue Chen, Li Zhou, Jiangxia Ren, Mingfen Tian, Qinghuan Yang, Ling Wang, Youlin Wu, Jun Wen, Qin Yang
The moderate formation of the fibrotic scar plays an important role in functional recovery after stroke. M2a macrophages have been identified as an important source of early fibrosis after cerebral ischemia. However, the underlying mechanisms by which macrophages interact with fibroblasts in this context remain largely unknown. Therefore, our study aimed to further investigate the potential mechanisms
-
Regulatory T lymphocytes in traumatic brain injury Neurochem. Int. (IF 4.2) Pub Date : 2023-12-25 Jiajing Shan, Ruyu Shi, Rimi Hazra, Xiaoming Hu
Traumatic brain injury (TBI) presents a significant global health challenge with no effective therapies developed to date. Regulatory T lymphocytes (Tregs) have recently emerged as a potential therapy due to their critical roles in maintaining immune homeostasis, reducing inflammation, and promoting brain repair. Following TBI, fluctuations in Treg populations and shifts in their functionality have
-
Pharmacogenetics of selective serotonin reuptake inhibitors (SSRI): A serotonin reuptake transporter (SERT)-based approach Neurochem. Int. (IF 4.2) Pub Date : 2023-12-27 V. Sreeja, Anju Jose, Shashikant Patel, Bindu Menon, K.V. Athira, Sumana Chakravarty
Neuropsychiatric disorders are considered to be the most common cause of disability worldwide. Serotonin and its transporter is a prominent paradigm in mood disorders. Response to selective serotonin reuptake inhibitors (SSRI) is altered due to heterogeneity in the serotonin transporter gene, SLC6A4 (solute carrier family 6 member 4). The reported polymorphisms are found to be in different regions
-
Long-term intermittent theta burst stimulation enhanced hippocampus-dependent memory by regulating hippocampal theta oscillation and neurotransmitter levels in healthy rats Neurochem. Int. (IF 4.2) Pub Date : 2023-12-27 Xiang Wu, Jian Liu, Yanping Hui, Zhongheng Wu, Ling Wang, Yixuan Wang, Yihua Bai, Jing Li, Lei Zhang, Yue Xi, Qiaojun Zhang, Libo Li
Intermittent theta burst stimulation (iTBS), an updated pattern of high-frequency repetitive transcranial magnetic stimulation, is a potential candidate for improving memory. The hippocampus has been shown to be involved in the memory-enhancing effect induced by iTBS. However, it remains largely unknown whether this effect is achieved by regulating hippocampal theta oscillation and neurotransmitters
-
The intestinal microbiota exerts a sex-specific influence on neuroinflammation in a Parkinson's disease mouse model Neurochem. Int. (IF 4.2) Pub Date : 2023-12-27 Xiaoting Zhou, Yuan Gao, Jing Wei, Jie Luo, Yun Wang, Mengyun Yue, Bo Wang, Daojun Hong, Tingtao Chen, Xin Fang
Parkinson's disease (PD) is a neurodegenerative disorder characterised by chronic and progressive symptoms; it is more prevalent in men than in women. The sex-specific influence of the intestinal microbiota has been associated with some neurodegenerative diseases, but the relationship with PD is currently unclear. In this study, we treated mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
-
Epigenetic regulation in epilepsy: A novel mechanism and therapeutic strategy for epilepsy Neurochem. Int. (IF 4.2) Pub Date : 2023-12-23 Shuang Chen, Ming Huang, Da Xu, Man Li
Epilepsy is a common neurological disorder characterized by recurrent seizures with excessive and abnormal neuronal discharges. Epileptogenesis is usually involved in neuropathological processes such as ion channel dysfunction, neuronal injury, inflammatory response, synaptic plasticity, gliocyte proliferation and mossy fiber sprouting, currently the pathogenesis of epilepsy is not yet completely understood
-
Vepoloxamer improves functional recovery in rat after traumatic brain injury: A dose-response and therapeutic window study Neurochem. Int. (IF 4.2) Pub Date : 2023-12-22 Liang Chen, Ye Xiong, Michael Chopp, Haiyan Pang, Marty Emanuele, Zheng Gang Zhang, Asim Mahmood, Yanlu Zhang
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. There are no effective therapies available for TBI patients. Vepoloxamer is an amphiphilic polyethylene-polypropylene-polyethylene tri-block copolymer that seals membranes and restores plasma membrane integrity in damaged cells. We previously demonstrated that treatment of TBI rats with Vepoloxamer improves functional
-
Changes in excitatory amino acid transporters in response to remote ischaemic preconditioning and glutamate excitotoxicity Neurochem. Int. (IF 4.2) Pub Date : 2023-12-20 Jana Končeková, Klaudia Kotorová, Miroslav Gottlieb, Martin Bona, Petra Bonová
The successful implementation of remote ischaemic conditioning as a clinical neuroprotective strategy requires a thorough understanding of its basic principles, which can be modified for each patient. The mechanisms of glutamate homeostasis appear to be a key component. In the current study, we focused on the brain-to-blood glutamate shift mediated by glutamate transporters (excitatory amino acid transports
-
Trends and hotspots in research of traumatic brain injury from 2000 to 2022: A bibliometric study Neurochem. Int. (IF 4.2) Pub Date : 2023-12-06 Yan-rui Long, Kai Zhao, Fu-chi Zhang, Yu Li, Jun-wen Wang, Hong-quan Niu, Jin Lei
Traumatic brain injury (TBI) is a major health concern globally, which is characterized by high morbidity and mortality rates. Since the 21st century, TBI has received increasing attention and the number of publications is growing rapidly. This study aimed to characterize the volume and quality of scholarly output on TBI and identify the most impactful literature, research trends, and hotspots from
-
Research progress on mechanisms of ischemic stroke: Regulatory pathways involving Microglia Neurochem. Int. (IF 4.2) Pub Date : 2023-12-09 Xin Gao, Gang Su, Miao Chai, Minghui Shen, Zhenzhen Hu, Wei Chen, Juan Gao, Ruixin Li, Tianfei Ma, Yang An, Zhenchang Zhang
Microglia, as the intrinsic immune cells in the brain, are activated following ischemic stroke. Activated microglia participate in the pathological processes after stroke through polarization, autophagy, phagocytosis, pyroptosis, ferroptosis, apoptosis, and necrosis, thereby influencing the injury and repair following stroke. It has been established that polarized M1 and M2 microglia exhibit pro-inflammatory
-
An overview of mild traumatic brain injuries and emerging therapeutic targets Neurochem. Int. (IF 4.2) Pub Date : 2023-12-09 John P. Bielanin, Shamseldin A.H. Metwally, Satya S. Paruchuri, Dandan Sun
The majority of traumatic brain injuries (TBIs), approximately 90%, are classified as mild (mTBIs). Globally, an estimated 4 million injuries occur each year from concussions or mTBIs, highlighting their significance as a public health crisis. TBIs can lead to substantial long-term health consequences, including an increased risk of developing Alzheimer's Disease, Parkinson's Disease (PD), chronic
-
Inhibition of PTEN-induced kinase 1 autophosphorylation may assist in preventing epileptogenesis induced by pentylenetetrazol Neurochem. Int. (IF 4.2) Pub Date : 2023-11-27 Yaru Cui, Yujie Zhai, Yi Yuan, Xiaoqian Wang, Qianqian Xu, Xiangdong Wu, Linlin Xu, Tianpu Ren, Qiaoyun Wang, Hongliu Sun
-
Interleukin-33 has the protective effect on oligodendrocytes against impairment induced by cuprizone intoxication Neurochem. Int. (IF 4.2) Pub Date : 2023-11-26 Hui-Ting Huang, Shun-Fen Tzeng
Our prior investigations have demonstrated the pivotal role of IL-33 in facilitating the maturation of oligodendrocytes (OLs), prompting our interest in exploring its potential therapeutic effects. In this study, our focus was directed towards deciphering the functions of interleukin-33 (IL-33) in established demyelinating mouse model induced by the feeding of cuprizone (CPZ)-containing diet. We observed
-
Matrix Metalloproteinase-9 inhibitors as therapeutic drugs for traumatic brain injury Neurochem. Int. (IF 4.2) Pub Date : 2023-11-24 Angel Sunny, Raisa Rani James, Swathi Radhakrishnan Menon, Swetha Rayaroth, Abhijith Daniel, Namita Ann Thompson, Binu Tharakan
Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality among young adults and the elderly. In the United States, TBI is responsible for around 30 percent of all injuries brought on by injuries in general. Vasogenic cerebral edema due to blood-brain barrier (BBB) dysfunction and the associated elevation of intracranial pressure (ICP) are some of the major causes of secondary
-
Role of regulatory non-coding RNAs in traumatic brain injury Neurochem. Int. (IF 4.2) Pub Date : 2023-11-24 Shun Li, Na Qiu, Andrew Ni, Milton H. Hamblin, Ke-Jie Yin
Traumatic brain injury (TBI) is a potentially fatal health event that cannot be predicted in advance. After TBI occurs, it can have enduring consequences within both familial and social spheres. Yet, despite extensive efforts to improve medical interventions and tailor healthcare services, TBI still remains a major contributor to global disability and mortality rates. The prompt and accurate diagnosis
-
Calcium-binding protein parvalbumin in the spinal cord and dorsal root ganglia Neurochem. Int. (IF 4.2) Pub Date : 2023-11-13 Aleksandr Veshchitskii, Natalia Merkulyeva
Parvalbumin is one of the calcium-binding proteins. In the spinal cord, it is mainly expressed in inhibitory neurons; in the dorsal root ganglia, it is expressed in proprioceptive neurons. In contrast to in the brain, weak systematization of parvalbumin-expressing neurons occurs in the spinal cord. The aim of this paper is to provide a systematic review of parvalbumin-expressing neuronal populations
-
Brain cholesterol homeostasis and its association with neurodegenerative diseases Neurochem. Int. (IF 4.2) Pub Date : 2023-11-08 Yi Gao, Shiying Ye, Yuehong Tang, Wenjuan Tong, Shaowei Sun
The brain is the most cholesterol-rich organ in mammals. However, cholesterol metabolism in the brain is completely independent of other tissues due to the presence of the blood-brain barrier (BBB). Neurons, astrocytes and oligodendrocytes are the main cells responsible for cholesterol synthesis in the brain. The cholesterol content in the brain is maintained at a relatively constant level under strict
-
Projections from anteromedial thalamus nucleus to the midcingulate cortex mediate pain and anxiety-like behaviors in mice Neurochem. Int. (IF 4.2) Pub Date : 2023-11-10 Jie Hong, Jia-Ni Li, Feng-Ling Wu, Shang-Yi Bao, Han-Xue Sun, Ke-Hua Zhu, Zhi-Ping Cai, Fei Li, Yun-Qing Li
Prior research has demonstrated the involvement of the midcingulate cortex (MCC) and its downstream pathway in pain regulation. However, the mechanism via which pain information is conveyed to the MCC remains unclear. The present study utilized immunohistochemistry, chemogenetics, optogenetics, and behavior detection methods to explore the involvement of MCC, anteromedial thalamus nucleus (AM), and
-
P2Y12 receptor mediates apoptosis and demyelination to affect functional recovery in mice with spinal cord injury Neurochem. Int. (IF 4.2) Pub Date : 2023-11-10 Xiaodan Mi, Chengtao Ni, Jingting Zhao, Nashwa Amin, Dian Jiao, Marong Fang, Xiangming Ye
Among diseases of the central nervous system (CNS), spinal cord injury (SCI) has a high fatality rate. It has been proven that P2Y G protein-coupled purinergic receptors have a neuroprotective role in apoptosis and regeneration inside the damaged spinal cord. The P2Y12 receptor (P2Y12R) has recently been linked to peripheral neuropathy and stroke. However, the role of P2Y12R after SCI remains unclear
-
Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation-neglected multidimensional regulation of microglia Neurochem. Int. (IF 4.2) Pub Date : 2023-11-03 Xin Zhang, Xue Chen, Ling Zhang, Yuqing Sun, Ying Liang, Huan Li, Yulin Zhang
Neuroinflammation is an inflammatory cascade involved in various neurological disorders, including Alzheimer's disease, multiple sclerosis, and other relevant diseases. The triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane immune receptor that is primarily expressed by microglia in the central nervous system (CNS). While TREM2 is initially believed to be an anti-inflammatory
-
An immunomodulatory role of Fc receptor γ chain independent of FcγR ligation by IgG in acute neuroinflammation triggered by MPTP intoxication Neurochem. Int. (IF 4.2) Pub Date : 2023-11-03 Junguo Chen, Congmin Chen, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Aberrant microglial activation is a prominent feature of neuroinflammation, which is implicated in the pathogenesis of neurological disorders. Fc receptor common γ-chain (FcRγ), one of the two immunoreceptor tyrosine-based activation motif-bearing adaptor proteins, is abundantly expressed in microglia. It couples with different receptors, such as receptors for the Fc portion of IgG. In this study,
-
Mitochondrial protein prohibitin promotes learning memory recovery in mice following intracerebral hemorrhage via CAMKII/CRMP signaling pathway Neurochem. Int. (IF 4.2) Pub Date : 2023-11-03 Tianlin Jiang, Jiahua Wang, Yanli Wang, Jiwei Jiang, Jiawei Zhou, Xiaohong Wang, Deke Zhang, Jun Xu
Prohibitin (PHB) is a mitochondrial inner membrane protein with neuroprotective, antioxidant, and apoptosis-reducing effects. This study aimed to explore the role of PHB in pathological symptoms, behavioral deficits, and cognitive impairment in a collagenase-IV-induced intracerebral hemorrhage (ICH) murine model. In this study, mice that received collagenase IV injection were pretreated with PHB or
-
Mechanism of anti-AD action of OAB-14 by enhancing the function of glymphatic system Neurochem. Int. (IF 4.2) Pub Date : 2023-10-29 Xian Zhang, Ruolin Cao, Chao Zhu, Luxi Yang, Na Zheng, Wenshuang Ji, Peng Liu, Tianyan Chi, Xuefei Ji, Zhonghui Zheng, Guoliang Chen, Libo Zou
The number of patients with Alzheimer's disease is increasing year by year, but only a few medications are available. We found that OAB-14, a new small molecule, can improve cognitive deficits in various mouse AD models. The structure and mechanism of OAB-14 are distinct from anti-AD medications that have been unsuccessful in recent clinical trials. OAB-14 can effectively reduce the accumulation of
-
Estrogen receptor β exerts neuroprotective effects by fine-tuning mitochondrial homeostasis through NRF1/PGC-1α Neurochem. Int. (IF 4.2) Pub Date : 2023-10-28 Wei Zhao, Yue Hou, Qiwei Zhang, Haiyang Yu, Meichen Meng, Hanting Zhang, Yanmeng Zhou