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Transient receptor potential vanilloid-1 (TRPV1) channels act as suppressors of the growth of glioma Brain Res. Bull. (IF 3.8) Pub Date : 2024-04-16 Jingjing Cheng, Mengliu Zeng, Biwen Peng, Ping Li, Shiyu Zhao
The aim of this study was to investigate the expression and function of the transient receptor potential vanilloid 1 (TRPV1) in glioma. We found that the expression of TRPV1 mRNA and protein were upregulated in glioma compared with normal brain by qPCR and western blot analysis. In order to investigate the function of TRPV1 in glioma, short hairpin RNA (shRNA) and the inhibitor of TRPV1 were used.
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Mesenchymal stem cell-derived exosomes overexpressing SRC-3 protect mice from cerebral ischemia by inhibiting ferroptosis Brain Res. Bull. (IF 3.8) Pub Date : 2024-04-16 Mingyang Deng, Ying Hou, Jianyang Liu, Jialin He, Ziwei Lan, Han Xiao
The treatment for cerebral ischemia remains limited, and new therapeutic strategies are urgently needed. Exosome has shown great promise for the treatment of cerebral ischemia. Steroid receptor coactivator-3 (SRC-3) was reported to be involved in neurological performances. In this study, we aimed to investigate the protective effects of mesenchymal stem cell (MSC)-derived exosomes overexpressing SRC-3
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Abnormal functional connectivity of white-matter networks and gray-white matter functional networks in patients with NMOSD Brain Res. Bull. (IF 3.8) Pub Date : 2024-04-12 Xincui Wan, Yingjie Tang, Yu Wu, Zhenming Xu, Wangsheng Chen, Feng Chen, Cheng Luo, Fei Wang
Cognitive impairment (CI) has been reported in 29–70% of patients with neuromyelitis optica spectrum disorder (NMOSD). Abnormal white matter (WM) functional networks that correlate with cognitive functions have not been studied well in patients with NMOSD. The aim of the current study was to investigate functional connectivity (FC), spontaneous activity, and functional covariance connectivity (FCC)
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Causal interactions in brain networks predict pain levels in trigeminal neuralgia Brain Res. Bull. (IF 3.8) Pub Date : 2024-04-12 Yun Liang, Qing Zhao, John K. Neubert, Mingzhou Ding
Trigeminal neuralgia (TN) is a highly debilitating facial pain condition. Magnetic resonance imaging (MRI) is the main method for generating insights into the central mechanisms of TN pain in humans. Studies have found both structural and functional abnormalities in various brain structures in TN patients as compared with healthy controls. Whereas studies have also examined aberrations in brain networks
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Brain morphological changes and functional neuroanatomy related to cognitive and emotional distractors during working memory maintenance in post-traumatic stress disorder Brain Res. Bull. (IF 3.8) Pub Date : 2024-04-12 Gwang-Won Kim, Jong-Il Park, Jong-Chul Yang
Post-traumatic stress disorder (PTSD) is associated with abnormalities in the processing and regulation of emotion as well as cognitive deficits. This study evaluated the differential brain activation patterns associated with cognitive and emotional distractors during working memory (WM) maintenance for human faces between patients with PTSD and healthy controls (HCs) and assessed the relationship
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Combining fecal 16 S rRNA sequencing and spinal cord metabolomics analysis to explain the modulatory effect of PPARα on neuropathic pain Brain Res. Bull. (IF 3.8) Pub Date : 2024-04-12 Zi-Jun Wu, Yu-Ying Zhao, Shu-jing Hao, Bei-bei Dong, Yu-xin Zheng, Bin Liu, Jing Li
Existing evidence suggests that the composition of the gut microbiota is associated with neuropathic pain (NP), but the mechanistic link is elusive. Peroxisome proliferator-activated receptor α (PPARα) has been shown to be a pharmacological target for the treatment of metabolic disorders, and its expression is also involved in inflammatory regulation. The aim of this study was to investigate the important
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Preoperative recovery sleep ameliorates postoperative cognitive dysfunction aggravated by sleep fragmentation in aged mice by enhancing EEG delta-wave activity and LFP theta oscillation in hippocampal CA1 Brain Res. Bull. (IF 3.8) Pub Date : 2024-04-10 Yun Li, Shaowei Hou, Feixiang Li, Siwen Long, Yue Yang, Yize Li, Lina Zhao, Yonghao Yu
Sleep fragmentation (SF) is a common sleep problem experienced during the perioperative period by older adults, and is associated with postoperative cognitive dysfunction (POCD). Increasing evidence indicates that delta-wave activity during non-rapid eye movement (NREM) sleep is involved in sleep-dependent memory consolidation and that hippocampal theta oscillations are related to spatial exploratory
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Isobavachalcone alleviates ischemic stroke by suppressing HDAC1 expression and improving M2 polarization Brain Res. Bull. (IF 3.8) Pub Date : 2024-04-09 Qiannan Zhang, Junting Dai, Yongzhong Lin, Miao Li
Ischemic stroke is a serious cerebrovascular condition. Isobavachalcone (ISO) has been documented to exhibit an anti-inflammatory effect across a variety of diseases; however, its protective impact on ischemic stroke remains unexplored. In this study, we evaluated the influence of ISO in both transient middle cerebral artery occlusion/reperfusion (tMCAO/R) rat models and oxygen-glucose deprivation/reperfusion
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Concurrent brain structural and functional alterations in the thalamus of adult survivors of childhood brain tumors: a multimodal MRI study Brain Res. Bull. (IF 3.8) Pub Date : 2024-04-02 Jinfeng Hou, Tricia Z. King, Hongbo Chen, Qian Wang, You Xie, Hui Mao, Liya Wang, Luqi Cheng
Adult survivors of childhood brain tumors often present with cognitive deficits that affect their quality of life. Studying brain structure and function in brain tumor survivors can help understand the underlying mechanisms of their cognitive deficits to improve long-term prognosis of these patients. This study analyzed voxel-based morphometry (VBM) derived from T1-weighted MRI and the amplitude of
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Triptolide alleviates cerebral ischemia/reperfusion injury via regulating the Fractalkine/CX3CR1 signaling pathway Brain Res. Bull. (IF 3.8) Pub Date : 2024-04-02 Jiajun Zhou, Wei Ye, Ling Chen, Junheng Li, Yijun Zhou, Chunfeng Bai, Lian Luo
To evaluate the potential efficacy of Triptolide (TP) on cerebral ischemia/reperfusion injury (CIRI) and to uncover the underlying mechanism through which TP regulates CIRI. We constructed a middle cerebral artery occlusion/reperfusion (MCAO/R) mouse model to simulate CIRI, and established a lipopolysaccharide (LPS)-stimulated BV-2 cell model to mimic the inflammatory state during CIRI. The neurological
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Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol Brain Res. Bull. (IF 3.8) Pub Date : 2024-04-01 Shelby Travaglianti, Ahmed Alotaibi, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Youssef Sari
Chronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mPFC) and nucleus accumbens (NAc), and consequently leading to oxidative stress and neuroinflammation. Previous studies from our lab tested β-lactam antibiotics and novel beta-lactam non-antibiotic, MC-100093, and showed these β-lactam upregulated the
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Single-cell sequencing analysis of chronic subdural hematoma cell subpopulations and their potential therapeutic mechanisms Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-28 Qian Zhang, Rundong Chen, Lufeng Shi, Hehe Zhao, Fei Yin, Cong Yu, Yirong Wang, Peng Lu
Chronic subdural hematoma (CSDH) is a prevalent form of intracranial haemorrhage encountered in neurosurgical practice, and its incidence has notably risen in recent years. Currently, there is a lack of studies that have comprehensively classified the cells present in hematomas removed during surgery, and their correlation with CSDH recurrence remains elusive. This study aims to analyse the subcellular
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Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD study Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-18 Daniel J. Petrie, Kathleen D. Meeks, Zachary F. Fisher, Charles F. Geier
Obsessive-compulsive symptoms (OCS) are relatively common during adolescence although most individuals do not meet diagnostic criteria for obsessive-compulsive disorder (OCD). Nonetheless, OCS during adolescence are associated with comorbid psychopathologies and behavioral problems. Heightened levels of environmental stress and greater functional connectivity between the somatomotor network and putamen
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Consistent abnormal activity in the putamen by dopamine modulation in Parkinson’s disease: A resting-state neuroimaging meta-analysis Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-18 Danyan Rong, Chuan-Peng Hu, Jiaying Yang, Zhiying Guo, Weiguo Liu, Miao Yu
This study aimed to elucidate brain areas mediated by oral anti-parkinsonian medicine that consistently show abnormal resting-state activation in PD and to reveal their functional connectivity profiles using meta-analytic approaches. Searches of the PubMed, Web of Science databases identified 78 neuroimaging studies including PD OFF state (PD-OFF) versus (vs.) PD ON state (PD-ON) or PD-ON versus healthy
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Sleep deprivation changes frequency-specific functional organization of the resting human brain Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-16 Zhiguo Luo, Erwei Yin, Ye Yan, Shaokai Zhao, Liang Xie, Hui Shen, Ling-Li Zeng, Lubin Wang, Dewen Hu
Previous resting-state functional magnetic resonance imaging (rs-fMRI) studies have widely explored the temporal connection changes in the human brain following long-term sleep deprivation (SD). However, the frequency-specific topological properties of sleep-deprived functional networks remain virtually unclear. In this study, thirty-seven healthy male subjects underwent resting-state fMRI during rested
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Inhibition of lysyl oxidase by pharmacological intervention and genetic manipulation alleviates epilepsy-associated cognitive disorder Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-15 Kang-Ni Chen, Qi-Lin Peng, Dan-Feng Cao, Zhao-Jun Wang, Kai Zhang, Xin-Yu Zhou, Dong-Yu Min, Bo-Ting Zhou, Xiao-Yuan Mao
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Corrigendum to “RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ß and JNK signaling pathways in dopaminergic neuron-like cells” [Brain Res. Bull. 146 (2019) 228–236] Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-14 Xiao-Ling Zhang, Zhen-Zhen Wang, Qian-Hang Shao, Zhao Zhang, Lin Li, Zhen-Yu Guo, Hong-Mei Sun, Yi Zhang, Nai-Hong Chen
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Serum S100B protein and white matter changes in schizophrenia before and after medication Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-12 Han Shi, Yan Zhang, Yongfeng Yang, Haisan Zhang, Wenqiang Li, Zhaoxi Zhong, Luxian Lv
Schizophrenia patients have abnormalities in white matter (WM) integrity in brain regions. S100B has been shown to be a marker protein for glial cells. The atypical antipsychotics have neuroprotective effects on the brain. It is not clear whether antipsychotics can induce S100B changes and improve symptoms by protecting oligodendrocytes. To investigate WM and S100B changes and associations and determine
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The role of attention in immersion: The two–competitor model Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-08 Daniel J. Strauss, Alexander L. Francis, Jonas Vibell, Farah I. Corona–Strauss
Currently, we face an exponentially increasing interest in immersion, especially sensory–driven immersion, mainly due to the rapid development of ideas and business models centered around a digital virtual universe as well as the increasing availability of affordable immersive technologies for education, communication, and entertainment. However, a clear definition of ‘immersion’, in terms of established
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Mechanisms and protective measures for radiation-induced brachial plexus nerve injury Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-07 Jia ying Wei, Li xin Ma, Wen tong Liu, Li hua Dong, Xue Hou, Xue ying Bao, Wei Hou
Radiation therapy is a common treatment modality for patients with malignant tumors of the head and neck, chest and axilla. However, radiotherapy inevitably causes damage to normal tissues at the irradiated site, among which damage to the brachial plexus nerve(BP) is a serious adverse effect in patients receiving radiation therapy in the scapular or axillary regions, with clinical manifestations including
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Targeting blood-brain barrier for sepsis-associated encephalopathy: Regulation of immune cells and ncRNAs Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-06 Mi Tian, Yunliang Zhan, Jinyuan Cao, Jinqi Gao, Jie Sun, Li Zhang
Sepsis causes significant morbidity and mortality worldwide, most surviving patients show acute or chronic mental disorders, which are known as sepsis-associated encephalopathy (SAE). SAE involves many pathological processes, including the blood-brain barrier (BBB) damage. The BBB is located at the interface between the central nervous system and the surrounding environment, which protects the central
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Global research evolution and frontier analysis of artificial intelligence in brain injury: A bibliometric analysis Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-05 Mengqi Qu, Yang Xu, Lu Lu
Research on artificial intelligence for brain injury is currently a prominent area of scientific research. A significant amount of related literature has been accumulated in this field. This study aims to identify hotspots and clarify research resources by conducting literature metrology visualization analysis, providing valuable ideas and references for related fields. The research object of this
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Tunneling nanotubes: The transport highway for astrocyte-neuron communication in the central nervous system Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-05 Cuixiang Zhou, Min Huang, Shasha Wang, Shifeng Chu, Zhao Zhang, Naihong Chen
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Rosiglitazone regulates astrocyte polarization and neuroinflammation in a PPAR-γ dependent manner after experimental traumatic brain injury Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-02 Xu Ren, Yun-Fei Li, Tian-Wei Pei, Hao-Sheng Wang, Yu-Hai Wang, Tao Chen
Traumatic brain injury (TBI) is a leading cause of high mortality and disability worldwide. Overactivation of astrocytes and overexpression of inflammatory responses in the injured brain are characteristic pathological features of TBI. Rosiglitazone (ROS) is a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist known for its anti-inflammatory activity. However, the relationship between the
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Functional interaction of abnormal beta and gamma oscillations on bradykinesia in parkinsonian rats Brain Res. Bull. (IF 3.8) Pub Date : 2024-03-02 Xinxin Jiang, Jian Yang, Zirui Wang, Jun Jia, Gang Wang
Bradykinesia, a debilitating symptom characterized by impaired movement initiation and reduced speed in Parkinson’s disease (PD), is associated with abnormal oscillatory activity in the motor cortex-basal ganglia circuit. We investigated the interplay between abnormal beta and gamma oscillations in relation to bradykinesia in parkinsonian rats. Our findings showed reduced movement activities in parkinsonian
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The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-29 Ayman Alzu'bi, Worood Bani Baker, Bahaa Al-Trad, Mazhar Salim Al Zoubi, Manal Isam AbuAlArjah, Ejlal Abu-El-Rub, Lena Tahat, Ahmed MNZ Helaly, Doaa S. Ghorab, Waseem El-Huneidi, Raed M. Al-Zoubi
Fentanyl, a fully synthetic opioid, is widely used for severe pain management and has a huge abuse potential for its psychostimulant effects. Unlike other opioids, the neurotoxic effects of chronic fentanyl administration are still unclear. In particular, little is known about its effect on the cerebral cortex. The current study aims to test the chronic toxicity of fentanyl in the mice model. Adult
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Exercise attenuates the perioperative neurocognitive disorder induced by hyperhomocysteinemia in mice Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-28 Qian Zhang, Peilin Cong, Li Tian, Tingmei Wu, Xinwei Huang, Yuxin Zhang, Huanghui Wu, Huazheng Liang, Lize Xiong
The perioperative neurocognitive disorder (PND) is a severe complication that affects millions of surgical patients each year. Homocysteine (Hcy) is known to increase the risk of developing PND in both young and elderly mice. However, whether Hcy alone can induce cognitive deficits in middle-aged mice (12-month-old), whether exercise can attenuate Hcy-induced hippocampus-related cognitive deficits
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The role of neuroglial cells communication in ischemic stroke Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-27 Yunling Yu, Xinglan Liao, Xinyu Xie, Qihua Li, Xuehong Chen, Ruizhen Liu
Ischemic stroke is one of the leading causes of death and disability globally, but its treatment options are limited due to therapeutic window and reperfusion injury constraints. Microglia, astrocytes, and oligodendrocytes are the major components of the neurovascular unit, and there is substantial evidence suggesting their contributions to maintaining homeostasis in the central nervous system. Neuroglial
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Enriched environment treatment promotes neural functional recovery together with microglia polarization and remyelination after cerebral ischemia in rats Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-27 Yu Han, Xinya Shen, Zhenkun Gao, Pingping Han, Xia Bi
Microglia activation and oligodendrocyte maturation are critical for remyelination after cerebral ischemia. Studies have shown that enriched environment (EE) can effectively alleviate stroke-induced neurological deficits. However, little is known about the mechanism associated with glial cells underlying the neuroprotection of EE. Therefore, this study focuses on investigating the effect of EE on activated
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NTPDase1-ATP-P2Y2Rs axis in the sciatic nerve contributes to acupuncture at “Zusanli” (ST36)-induced analgesia in ankle arthritis rats Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-23 Jing-Wen Xu, Si-Qi Tang, Jie Lin, Yu-Jia Li, Dan Shen, Guang-Hong Ding, Xue-Yong Shen, Li-Na Wang
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Integrated analysis of circRNA- related ceRNA network targeting neuroinflammation in medial temporal lobe epilepsy Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-23 Bingzheng Gong, Mian Li, Ziru Wang, Gulingyue Hao, Liang Sun, Jingjun Zhang, Liangjie Yuan
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Aerobic exercise modulates the striatal Erk/MAPK signaling pathway and improves LID in a mouse model of Parkinson's disease Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-22 Fangyuan Zhou, Longwei Wei, Yinhao Wang, Wei Chen
To investigate the role of the striatal extracellular signal-regulated kinase (Erk1/2) and its phosphorylation (p-Erk1/2) in aerobic training to alleviate the development of the L-DOPA induced dyskinesia (LID) in PD mice. Forty-eight male C57BL/6 N mice were randomly divided into the 6-OHDA surgery group (6-OHDA, n=42) and the sham surgery group (Sham, n=6). A two-point injection of 6-OHDA into the
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The dose-dependent neuroprotective effect of norepinephrine in improving memory retrieval in an experimental model of multiple sclerosis, experimental autoimmune encephalomyelitis Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-21 Narjes Taherian, Gholamhassan Vaezi, Ali Neamati, Vida Hojjati, Faezeh Ghorbani-Taherdehi, Amirhossein Sahebkar, Mahmoud Gorji-Valokola
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The role of T-lymphocytes in central nervous system diseases Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-20 Jianing Shen, Ning Bian, Lu Zhao, Jingkuan Wei
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Functional connectivity alterations in PTSD patients with suicidal ideation Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-19 Stephen Wood, Samuel Booth, Ji Hyun Ko
Post-traumatic stress disorder (PTSD) is a highly prevalent psychological disorder characterized by intense feelings of fear or helplessness after experiencing a traumatic event. PTSD is highly comorbid with mood disorders and patients are at increased risk for suicide. The present study aimed to identify neural connectivity alterations associated with suicidal ideation (SI) in PTSD patients by using
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Electroencephalography oscillations can predict the cortical response following theta burst stimulation Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-16 Guiyuan Cai, Jiayue Xu, Qian Ding, Tuo Lin, Hongying Chen, Manfeng Wu, Wanqi Li, Gengbin Chen, Guangqing Xu, Yue Lan
Continuous theta burst stimulation and intermittent theta burst stimulation are clinically popular models of repetitive transcranial magnetic stimulation. However, they are limited by high variability between individuals in cortical excitability changes following stimulation. Although electroencephalography oscillations have been reported to modulate the cortical response to transcranial magnetic stimulation
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Prolonged stress response induced by chronic stress and corticosterone exposure causes adult neurogenesis inhibition and astrocyte loss in mouse hippocampus Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-15 Hyun Seung Shin, Seung Hyun Lee, Ha Jung Moon, Yun Hee So, Hyeon Jung Jang, Kyung-Ha Lee, Changhwan Ahn, Eui-Man Jung
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Exploring resting-state EEG oscillations in patients with Neuromyelitis Optica Spectrum Disorder Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-15 Lili Yang, Congyu Xu, Yun Qin, Kai Chen, Yan Xie, Xiaobo Zhou, Tiejun Liu, Song Tan, Jie Liu, Dezhong Yao
Quantitative resting-state electroencephalography (rs-EEG) is a convenient method for characterizing the functional impairments and adaptations of the brain that has been shown to be valuable for assessing many neurological and psychiatric disorders, especially in monitoring disease status and assisting neuromodulation treatment. However, it has not yet been explored in patients with neuromyelitis
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Neonatal inhibition of androgen activity alters the programming of body weight and orexinergic peptides differentially in male and female rats Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-13 Beatriz Carrillo, Jose Manuel Fernandez-Garcia, Rocío García-Úbeda, Daniela Grassi, Ulises Primo, Noemí Blanco, Antonio Ballesta, Maria Angeles Arevalo, Paloma Collado, Helena Pinos
The involvement of androgens in the regulation of energy metabolism has been demonstrated. The main objective of the present research was to study the involvement of androgens in both the programming of energy metabolism and the regulatory peptides associated with feeding. For this purpose, androgen receptors and the main metabolic pathways of testosterone were inhibited during the first five days
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MGFKD: A semi-supervised multi-source domain adaptation algorithm for cross-subject EEG emotion recognition Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-12 Rui Zhang, Huifeng Guo, Zongxin Xu, Yuxia Hu, Mingming Chen, Lipeng Zhang
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Topological alteration of the brain structural network in Parkinson’s disease with apathy Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-08 Shaoyun Ge, Jun Liu, Yongfeng Jia, Zihan Li, Jianwei Wang, Min Wang
Apathy is a common neuropsychiatric manifestations in Parkinson’s disease (PD), but neural network mechanisms still remain elusive. We aim to investigate the topological alteration of the brain structural network in PD with apathy. In the present study, a total of 47 apathetic PD (aPD) patients, 37 non-apathetic PD (naPD) patients, and 40 healthy controls (HCs) were enrolled. Diffusion tensor imaging
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Physical and social environmental enrichment alleviate ferroptosis and inflammation with inhibition of TLR4/MyD88/p38MAPK pathway in chronic cerebral hypoperfusion rats Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-08 Bin Fan, Ying Zhang, Qihang Luo, Chizi Hao, Weijing Liao
A typical enriched environment (EE), which combines physical activity and social interaction, has been proven to mitigate cognitive impairment caused by chronic cerebral hypoperfusion (CCH). However, it remains unclear how the different components of EE promote cognitive recovery after CCH. This study stripped out the different components of EE into physical environmental enrichment (PE) and social
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Continuous inhalation of essential oil increases gray matter volume Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-07 Keisuke Kokubun, Kiyotaka Nemoto, Yoshinori Yamakawa
Research into the health benefits of scents is on the rise. However, little is known about the effects of continuous inhalation, such as wearing scents on clothing, on brain structure. Therefore, in this study, an intervention study was conducted on a total of 50 healthy female people, 28 in the intervention group and 22 in the control group, asking them to wear a designated rose scent on their clothes
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Upregulation of TRPC1 in microglia promotes neutrophil infiltration after ischemic stroke Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-05 Hao Qian, Hui-Nan Zhang, Tian Gao, Xin-Shang Wang, Xing Wang, Man-Yang Yu, Ming-Kai Li, Jing Huang
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Statistical analysis and generative Artificial Intelligence (AI) for assessing pain experience, pain-induced disability, and quality of life in Parkinson's disease patients Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-04 Luana Conte, Roberto Lupo, Pierluigi Lezzi, Alessio Pedone, Ivan Rubbi, Alessia Lezzi, Elsa Vitale, Antonio Fasano, Giorgio De Nunzio
The Parkinson's Disease (PD) is a chronic neurodegenerative condition characterized by motor symptoms such as tremors, rigidity, and bradykinesia, which can significantly impact various aspects of daily life. Among these aspects, pain is a prominent element. Despite the widespread use of therapies aimed at improving symptoms and quality of life, effective pain management is essential to enhance the
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IL-17A deficiency alleviates cerebral ischemia-reperfusion injury via activating ERK/MAPK pathway in hippocampal CA1 region Brain Res. Bull. (IF 3.8) Pub Date : 2024-02-01 Yanan Li, Qi Zhang, Xupeng Wang, Fang Xu, Junfang Niu, Juan Zhao, Qiujun Wang
Cognitive impairment is a major complication of cerebral ischemia–reperfusion (CIR) injury and has an important impact on the quality of life of patients. However, the precise mechanisms underlying cognitive impairment after CIR injury remain elusive. In the current study, we investigated the role of interleukin 17 A (IL-17A) on CIR injury-induced cognitive impairment in wild-type and IL-17A knockout
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Hippocampal-prefrontal high-gamma flow during performance of a spatial working memory Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-26 Wenwen Bai, Yinglong Liu, Aili Liu, Xinyu Xu, Xuyuan Zheng, Xin Tian, Tiaotiao Liu
Working memory refers to a system that provides temporary storage and manipulation of the information necessary for complex cognitive tasks. The prefrontal cortex (PFC) and hippocampus (HPC) are major structures contributing to working memory. Accumulating evidence suggests that the HPC-PFC interactions are critical for the successful execution of working memory tasks. Nevertheless, the directional
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Baicalein ameliorates cognitive impairment of vascular dementia rats via suppressing neuroinflammation and regulating intestinal microbiota Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-29 Jiaxi Song, Meixi Li, Ning Kang, Wei Jin, Yining Xiao, Zhe Li, Qianqian Qi, Jiayu Zhang, Yaxin Duan, Xiaoxiao Feng, Peiyuan Lv
Neuroinflammation induced by chronic cerebral hypoperfusion (CCH) plays a crucial role in the pathophysiologic mechanisms of vascular dementia (VD). A growing body of research has found that intestinal microbiota is associated with a variety of central nervous system disorders and that there is a relationship between intestinal microbiota dysbiosis and cognitive dysfunction and inflammatory responses
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Valproate attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress through inhibiting spinal IL-6 and STAT1 phosphorylation Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-28 Chen-Xi Xu, Xin-Yi Qiu, Yi Guo, Tian-Ming Xu, Richard J. Traub, Hai-Nan Feng, Dong-Yuan Cao
Temporomandibular disorder (TMD) and fibromyalgia syndrome (FMS) may present as comorbid conditions, but treatment options are ineffective. The purpose of this study was to investigate whether valproate (VPA) attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress, which represents a model of pain associated with TMD and FMS comorbidity, and to explore the potential mechanisms
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Wogonin alleviates NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/SIRT1 Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-20 Zhijuan Cheng, Jianglong Tu, Kai Wang, Fang Li, Yuan He, Wei Wu
Cerebral ischemia-reperfusion (IR) is the main pathophysiological process after stroke and can seriously impair neurological function. Wogonin, a natural flavonoid extracted from the roots of Scutellaria baicalensis, has potent anti-inflammatory properties. In this study, we investigated the protective mechanism of wogonin against middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation/reoxygenation
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Tumor necrosis factor receptor 2 activation elicits sex-specific effects on cortical myelin proteins and functional recovery in a model of multiple sclerosis Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-20 Kayla L. Nguyen, Ishaan J. Bhatt, Shruti Gupta, Nazaf Showkat, Kathryn A. Swanson, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Valerie Bracchi-Ricard, John R. Bethea
Multiple sclerosis (MS), a demyelinating autoimmune disease of the central nervous system (CNS), predominately affects females compared to males. Tumor necrosis factor (TNF), a pro-inflammatory cytokine, signaling through TNF receptor 1 contributes to inflammatory disease pathogenesis. In contrast, TNF receptor 2 signaling is neuroprotective. Current anti-TNF MS therapies are shown to be detrimental
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BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-19 Somaieh Matin, Masoomeh Dadkhah
Emerging evidence supports the gut microbiota and the brain communication in general health. This axis may affect behavior through modulating neurotransmission, and thereby involve in the pathogenesis and/or progression of different neuropsychiatric disorders such as depression. Brain-derived neurotrophic factor and cAMP response element-binding protein known as CREB/BDNF pathway plays have critical
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The seizure classification of focal epilepsy based on the network motif analysis Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-17 Denggui Fan, Lixue Qi, Songan Hou, Qingyun Wang, Gerold Baier
Due to the complexity of focal epilepsy and its risk for transiting to the generalized epilepsy, the development of reliable classification methods to accurately predict and classify focal and generalized seizures is critical for the clinical management of patients with epilepsy. In order to holistically understand the seizure propagation behavior of focal epilepsy, we propose a three-node motif reduced
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Rab3a attenuates spinal cord injury by mediating vesicle release Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-20 Yuhao Yang, Ziqiao Liu, Yang Lu, Xincheng Yu, Rui Zhu, Xingda Cai, Jinghua Lin, Zemin Wang, Dingsheng Zha
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EEG brain network variability is correlated with other pathophysiological indicators of critical patients in neurology intensive care unit Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-15 Chunli Chen, Zhaojin Chen, Meiling Hu, Sha Zhou, Shiyun Xu, Guan Zhou, Jixuan Zhou, Yuqin Li, Baodan Chen, Dezhong Yao, Fali Li, Yizhou Liu, Simeng Su, Peng Xu, Xuntai Ma
Continuous electroencephalogram (cEEG) plays a crucial role in monitoring and postoperative evaluation of critical patients with extensive EEG abnormalities. Recently, the temporal variability of dynamic resting-state functional connectivity has emerged as a novel approach to understanding the pathophysiological mechanisms underlying diseases. However, little is known about the underlying temporal
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Potential effects of the most prescribed drugs on the microbiota-gut-brain-axis: A review Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-18 Kirti Garg, M. Hasan Mohajeri
The link between drug-induced dysbiosis and its influence on brain diseases through gut-residing bacteria and their metabolites, named the microbiota-gut-brain axis (MGBA), remains largely unexplored. This review investigates the effects of commonly prescribed drugs (metformin, statins, proton-pump-inhibitors, NSAIDs, and anti-depressants) on the gut microbiota, comparing the findings with altered
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Hemodynamic signal changes during volitional swallowing in dysphagia patients with different unilateral hemispheric stroke and brainstem stroke: A near-infrared spectroscopy study Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-15 Xiancong Ma, Yang Peng, Lida Zhong, Fang Li, Zhouquan Tang, Xiao Bao, Jingjun Chen
Background and objectives Strokes will result in decreased in cortical excitability and changed in the balance between the affected and unaffected hemispheres. Previous studies have focused on cortical changes in healthy subjects during swallowing, while they remain unknown in patients with stroke at different locations. Thus, the purpose of this study was to research cortical activation patterns of
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Improvement of astrocytic gap junction involves the anti-depressive effect of celecoxib through inhibition of NF-κB Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-09 Xiao-xi Zheng, Cheng-feng Zhang, Li-qing Li, Jun-rui Ye, Si-yu Ren, Zhao Zhang, Xin He, Shi-feng Chu, Nai-hong Chen
Context Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, has been shown to exhibit anti-depressive effects in clinical trials. However, the direct mechanism underlying its effect on neuroinflammation remains unclear. Neuroinflammatory reaction from astrocytes leads to depression, and our previous study found that gap junction disorder between astrocytes aggravated neuroinflammatory reaction
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Deferoxamine reduces endothelial ferroptosis and protects cerebrovascular function after experimental traumatic brain injury Brain Res. Bull. (IF 3.8) Pub Date : 2024-01-12 Yidan Liang, Yanglingxi Wang, Chao Sun, Yi Xiang, Yongbing Deng
Cerebrovascular dysfunction resulting from traumatic brain injury (TBI) significantly contributes to poor patient outcomes. Recent studies revealed the involvement of iron metabolism in neuronal survival, yet its effect on vasculature remains unclear. This study aims to explore the impact of endothelial ferroptosis on cerebrovascular function in TBI. A Controlled Cortical Impact (CCI) model was established