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Transcranial focused ultrasound stimulation in the infralimbic cortex facilitates extinction of conditioned fear in rats Brain Stimul. (IF 7.7) Pub Date : 2024-03-26 Jaeyong Lee, Ye Eun Kim, Jihong Lim, Yehhyun Jo, Hyunjoo Jenny Lee, Yong Sang Jo, June-Seek Choi
Transcranial focused ultrasound (tFUS) neuromodulation emerges as a promising non-invasive approach for improving neurological conditions. Extinction of conditioned fear has served as a prime model for exposure-based therapies for anxiety disorders. We investigated whether tFUS stimulation to a critical brain area, the infralimbic subdivision of the prefrontal cortex (IL), could facilitate fear extinction
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Low frequency stimulation for seizure suppression: Identification of optimal targets in the entorhinal-hippocampal circuit Brain Stimul. (IF 7.7) Pub Date : 2024-03-24 Piret Kleis, Enya Paschen, Ute Häussler, Carola A. Haas
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Feasibility study of microburst VNS therapy in drug-resistant focal and generalized epilepsy Brain Stimul. (IF 7.7) Pub Date : 2024-03-16 Cornelia Drees, Pegah Afra, Ryan Verner, Lesley Kaye, Amy Keith, Mei Jiang, Jerzy P. Szaflarski, Kathryn Nichol, The Microburst Study Group, Danielle McDermott, Mesha Gay Brown, Michael Macken, Irena Bellinski, Elizabeth Cunningham, Rebecca O'Dwyer, Fiona Lynn, William O. Tatum, Selim R. Benbadis, Zeenat Jaisani, Muhammad Zafar, Blake Newman, Seyhmus Aydemir, Kristl Vonck, Ann Mertens, Jane Allendorfer
Vagus nerve stimulation (VNS) at low frequencies (≤30 Hz) has been an established treatment for drug-resistant epilepsy (DRE) for over 25 years. To examine the initial safety and efficacy performance of an investigational, high-frequency (≥250 Hz) VNS paradigm herein called “Microburst VNS” (μVNS). μVNS consists of short, high-frequency bursts of electrical pulses believed to preferentially modulate
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Neural mechanisms of the temporal response of cortical neurons to intracortical microstimulation Brain Stimul. (IF 7.7) Pub Date : 2024-03-16 Karthik Kumaravelu, Warren M. Grill
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Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom Brain Stimul. (IF 7.7) Pub Date : 2024-03-13 Adithya Sivaraju, Imran Quraishi, Evan Collins, Hari McGrath, Alexander Ramos, Nicholas B. Turk-Browne, Hitten Zaveri, Eyiyemisi Damisah, Dennis D. Spencer, Lawrence J. Hirsch
To prospectively investigate the utility of seizure induction using systematic 1Hz stimulation by exploring its concordance with the spontaneous seizure onset zone (SOZ) and relation to surgical outcome; comparison with seizures induced by non-systematic 50 Hz stimulation was attempted as well. Prospective cohort study from 2018-2021 with ≥ 1y post-surgery follow up at Yale New Haven Hospital. With
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High frequency transcranial magnetic stimulation increases slow-wave activity during subsequent sleep in older adults with cognitive complaints Brain Stimul. (IF 7.7) Pub Date : 2024-03-13 Kristine A. Wilckens, Ahmad Mayeli, Michelle E. Stepan, Christine W. Peng, Rima F. Habte, Kamakashi Sharma, Sabine A. Janssen, Savannah L. Applegate, Meredith L. Wallace, Daniel J. Buysse, Fabio Ferrarelli
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Bilateral intracortical inhibition during unilateral motor preparation and sequence learning Brain Stimul. (IF 7.7) Pub Date : 2024-03-11 R. Hamel, B.M. Waltzing, M.R. Hinder, C.J. McAllister, N. Jenkinson, J.M. Galea
Motor sequence learning gradually quickens reaction time, suggesting that sequence learning alters motor preparation processes. Interestingly, evidence has shown that preparing sequence movements decreases short intracortical inhibition (SICI) in the contralateral motor cortex (M1), but also that sequence learning alters motor preparation processes in both the contralateral and ipsilateral M1s. Therefore
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Tuning the brakes – Modulatory role of transcranial random noise stimulation on inhibition Brain Stimul. (IF 7.7) Pub Date : 2024-03-06 Alekhya Mandali, Flavie Torrecillos, Christoph Wiest, Alek Pogosyan, Shenghong He, Diogo Coutinho Soriano, Huiling Tan, Charlotte Stagg, Hayriye Cagnan
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When to hold and when to fold: Early prediction of nonresponse to transcranial magnetic stimulation in major depressive disorder Brain Stimul. (IF 7.7) Pub Date : 2024-03-06 Harold A. Sackeim, Scott T. Aaronson, Linda L. Carpenter, Todd M. Hutton, Kenneth Pages, Lindsay Lucas, Bing Chen
Determining when to recommend a change in treatment regimen due to insufficient improvement is a common challenge in therapeutics. In a sample of 7215 patients with major depressive disorder treated with transcranial magnetic stimulation (TMS) and with PHQ-9 scores before, during and after the course, 3 groups were identified based on number of acute course sessions: exactly 36 sessions (N = 3591)
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Transauricular Vagus Nerve Stimulation (taVNS) enhances Conditioned Pain Modulation (CPM) in healthy subjects: A randomized controlled trial Brain Stimul. (IF 7.7) Pub Date : 2024-03-05 Kevin Pacheco-Barrios, Anna Carolyna Gianlorenco, Lucas Camargo, Maria Fernanda Andrade, Hyuk Choi, Jae-Jun Song, Felipe Fregni
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Combining neuroimaging and brain stimulation to test alternative causal pathways for nicotine addiction in schizophrenia Brain Stimul. (IF 7.7) Pub Date : 2024-03-05 Xiaoming Du, Fow-Sen Choa, Joshua Chiappelli, Heather Bruce, Mark Kvarta, Ann Summerfelt, Yizhou Ma, William T. Regenold, Kevin Walton, George F. Wittenberg, Stephanie Hare, Si Gao, Andrew van der Vaart, Zhiwei Zhao, Shuo Chen, Peter Kochunov, L. Elliot Hong
The smoking rate is high in patients with schizophrenia. Brain stimulation targeting conventional brain circuits associated with nicotine addiction has also yielded mixed results. We aimed to identify alternative circuitries associated with nicotine addiction in both the general population and schizophrenia, and then test whether modulation of such circuitries may alter nicotine addiction behaviors
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Transcranial focused ultrasound of the amygdala modulates fear network activation and connectivity Brain Stimul. (IF 7.7) Pub Date : 2024-03-04 Tina Chou, Thilo Deckersbach, Bastien Guerin, Karianne Sretavan Wong, Benjamin M. Borron, Anish Kanabar, Ashley N. Hayden, Marina P. Long, Mohammad Daneshzand, Edward F. Pace-Schott, Darin D. Dougherty
Current noninvasive brain stimulation methods are incapable of directly modulating subcortical brain regions critically involved in psychiatric disorders. Transcranial Focused Ultrasound (tFUS) is a newer form of noninvasive stimulation that could modulate the amygdala, a subcortical region implicated in fear. We investigated the effects of active and sham tFUS of the amygdala on fear circuit activation
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Prestimulation neuronal activity predicts visual awareness of phosphene elicited by intracranial electrical stimulation Brain Stimul. (IF 7.7) Pub Date : 2024-03-04 Qian Wang, Guanpeng Chen, Xiongfei Wang, Ruolin Yang, Lu Luo, Haoran Ding, Pengfei Teng, Jing Wang, Leijie He, Jie Ren, Meng Zhao, Guoming Luan, Fang Fang
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Pilot study of stanford neuromodulation therapy (SNT) for bipolar depression Brain Stimul. (IF 7.7) Pub Date : 2024-03-04 Kristin S. Raj, Andrew D. Geoly, Clive Veerapal, Mia Gholmieh, Pouya Toosi, Flint M. Espil, Jean-Marie Batail, Ian H. Kratter, Nolan R. Williams
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Accelerated 1 Hz dorsomedial prefrontal transcranial magnetic stimulation for generalized anxiety disorder in adolescents and young adults: A case series Brain Stimul. (IF 7.7) Pub Date : 2024-03-03 Paul E. Croarkin, Aleksandra Dojnov, Victoria J. Middleton, Jennifer Bowman, Joseph Kriske, Nancy Donachie, Shan H. Siddiqi, Jonathan Downar
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Effects of different sonication parameters of theta burst transcranial ultrasound stimulation on human motor cortex Brain Stimul. (IF 7.7) Pub Date : 2024-03-03 Ke Zeng, Zhiwei Li, Xue Xia, Zhen Wang, Ghazaleh Darmani, Xiaoli Li, Robert Chen
Theta burst TUS (tbTUS) can induce increased cortical excitability in human, but how different sonication parameters influence the effects are still unknown. To examine how a range of sonication parameters, including acoustic intensity, pulse repetition frequency, duty cycle and sonication duration, influence the effects of tbTUS on human motor cortical excitability. 14 right-handed healthy subjects
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tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT) Brain Stimul. (IF 7.7) Pub Date : 2024-03-02 Hanna K. Hausman, Gene E. Alexander, Ronald Cohen, Michael Marsiske, Steven T. DeKosky, Georg A. Hishaw, Andrew O'Shea, Jessica N. Kraft, Yunfeng Dai, Samuel Wu, Adam J. Woods
Pharmacological interventions for depression and anxiety in older adults often have significant side effects, presenting the need for more tolerable alternatives. Transcranial direct current stimulation (tDCS) is a promising non-pharmacological intervention for depression in clinical populations. However, its effects on depression and anxiety symptoms, particularly in older adults from the general
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Transcranial current direct stimulation for improving working memory in patients with recent onset schizophrenia: An ARAS study Brain Stimul. (IF 7.7) Pub Date : 2024-02-29 Sara Farhang, Ali Reza Shafiee-kandjani, Arash Mohagheghi, Maryam Moghaddam, Fatemeh Ranjbar, Behrooz Z. Alizadeh, Wim Veling, Richard Bruggeman
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Temporally interfering electric fields brain stimulation in primary motor cortex of mice promotes motor skill through enhancing neuroplasticity Brain Stimul. (IF 7.7) Pub Date : 2024-02-29 Shuo Qi, Xiaodong Liu, Jinglun Yu, Zhiqiang Liang, Yu Liu, Xiaohui Wang
Temporal interference (TI) electric field brain stimulation is a novel neuromodulation technique that enables the non-invasive modulation of deep brain regions, but few advances about TI stimulation effectiveness and mechanisms have been reported. Conventional transcranial alternating current stimulation (tACS) can enhance motor skills, whether TI stimulation has an effect on motor skills in mice has
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EEG-based biomarkers predict individual differences in TMS-induced entrainment of intrinsic brain rhythms Brain Stimul. (IF 7.7) Pub Date : 2024-02-28 Jelena Trajkovic, Alexander T. Sack, Vincenzo Romei
Entrainment (increase) and modulation (shift) of intrinsic brain oscillations via rhythmic-TMS (rh-TMS) enables to either increase the amplitude of the individual peak oscillatory frequency, or experimentally slowing/accelerating this intrinsic peak oscillatory frequency by slightly shifting it. Both entrainment, and modulation of brain oscillations can lead to different measurable perceptual and cognitive
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Tonic and phasic transcutaneous auricular vagus nerve stimulation (taVNS) both evoke rapid and transient pupil dilation Brain Stimul. (IF 7.7) Pub Date : 2024-02-28 Lina Skora, Anna Marzecová, Gerhard Jocham
Transcutaneous auricular vagus nerve stimulation (tVNS or taVNS) is a non-invasive method of electrical stimulation of the afferent pathway of the vagus nerve, suggested to drive changes in putative physiological markers of noradrenergic activity, including pupil dilation. However, it is unknown whether different taVNS modes can map onto the phasic and tonic modes of noradrenergic activity. The effects
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Transcranial photobiomodulation increases intrinsic brain activity within irradiated areas in early Alzheimer's disease: Potential link with cerebral metabolism Brain Stimul. (IF 7.7) Pub Date : 2024-02-21 Naomi L. Gaggi, Katherine A. Collins, Javier Gonzalez-Castillo, Aura M. Hurtado, Francisco Xavier Castellanos, Ricardo Osorio, Paolo Cassano, Dan V. Iosifescu
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Driving Hebbian plasticity over ventral premotor-motor projections transiently enhances motor resonance Brain Stimul. (IF 7.7) Pub Date : 2024-02-21 Emilio Chiappini, Sonia Turrini, Marco Zanon, Mattia Marangon, Sara Borgomaneri, Alessio Avenanti
Making sense of others' actions relies on the activation of an action observation network (AON), which maps visual information about observed actions onto the observer's motor system. This motor resonance process manifests in the primary motor cortex (M1) as increased corticospinal excitability finely tuned to the muscles engaged in the observed action. Motor resonance in M1 is facilitated by projections
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Targeted and optimized multi-channel transcranial direct current stimulation for focal epilepsy: An N-of-1 trial Brain Stimul. (IF 7.7) Pub Date : 2024-02-21 Marios Antonakakis, Fabian Kaiser, Stefan Rampp, Stjepana Kovac, Heinz Wiendl, Walter Stummer, Joachim Gross, Christoph Kellinghaus, Maryam Khaleghi-Ghadiri, Gabriel Möddel, Carsten H. Wolters
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Bilateral theta burst stimulation modulates dorsolateral prefrontal cortex functional connectivity for emotion regulation in young adults: A randomized controlled trial Brain Stimul. (IF 7.7) Pub Date : 2024-02-18 Youze He, Baoru Zhao, Zhihan Liu, Zhaoying Li, Mengyu Han, Xiujuan Geng, Jingsong Wu
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In patients with late-life depression and cognitive decline, adding tDCS to cognitive training does not significantly affect depressive symptoms but shows potential benefits on cognition as measured by fMRI Brain Stimul. (IF 7.7) Pub Date : 2024-02-15 Junghee Ha, Yu Fang, Greg O. Cron, Jaeseok Heo, Eunjin Jung, Deokjong Lee, Hyunjeong Kim, Eosu Kim, Jin Young Park, Jin Hyung Lee
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Sequences and their shuffling may crucially impact coordinated reset stimulation – A theoretical study Brain Stimul. (IF 7.7) Pub Date : 2024-02-11 Justus A. Kromer, Peter A. Tass
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Reduction of alpha-synuclein oligomers in preclinical models of Parkinson’s disease by electrical stimulation in vitro and deep brain stimulation in vivo Brain Stimul. (IF 7.7) Pub Date : 2024-02-10 Eun Jung Lee, David Hernán Aguirre-Padilla, Anton Fomenko, Grishma Pawar, Minesh Kapadia, Jimmy George, Andres M. Lozano, Clement Hamani, Lorraine V. Kalia, Suneil K. Kalia
Deep brain stimulation (DBS) has been widely used to manage debilitating neurological symptoms in movement disorders such as Parkinson's disease (PD). Despite its well-established symptomatic benefits, our understanding of the mechanisms underlying DBS and its possible effect on the accumulation of pathological proteins in neurodegeneration remains limited. Accumulation and oligomerization of the protein
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Acoustic noise generated by TMS in typical environment and inside an MRI scanner Brain Stimul. (IF 7.7) Pub Date : 2024-02-09 Mikko J. Nyrhinen, Victor H. Souza, Risto J. Ilmoniemi, Fa-Hsuan Lin
The operation of a transcranial magnetic stimulation (TMS) coil produces high-intensity impulse sounds. In TMS, a magnetic field is generated by a short-duration pulse in the range of thousands of amperes in the TMS coil. When placed in a strong magnetic field, such as inside a magnetic resonance imaging (MRI) bore, the interaction of the magnetic field and the current in the TMS coil can cause strong
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Impact of multiple-session home-based transcranial direct current stimulation (M-HB-tDCS) on eating behavior in fibromyalgia: A factorial randomized clinical trial Brain Stimul. (IF 7.7) Pub Date : 2024-02-08 Manoela N.da Jornada, Luciana C. Antunes, Camila Alves, Iraci L.S. Torres, Felipe Fregni, Paulo R. S Sanches, Danton P Silva, Wolnei Caumo
Multiple-session home-based self-applied transcranial direct current stimulation (M-HB-self-applied-tDCS) has previously been found to effectively reduce chronic pain and enhance cognitive function. However, the effectiveness of this method for disordered eating behavior still needs to be studied. This study aimed to assess whether 20 sessions of M-HB-self-applied-tDCS, administered over four weeks
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Thalamic deep brain stimulation for tourette syndrome increases cortical beta activity Brain Stimul. (IF 7.7) Pub Date : 2024-02-08 Thomas Schüller, Daniel Huys, Sina Kohl, Veerle Visser-Vandewalle, Till A. Dembek, Jens Kuhn, Juan Carlos Baldermann, Ezra E. Smith
Deep brain stimulation (DBS) of the thalamus can effectively reduce tics in severely affected patients with Tourette syndrome (TS). Its effect on cortical oscillatory activity is currently unknown. We assessed whether DBS modulates beta activity at fronto-central electrodes. We explored concurrent EEG sources and probabilistic stimulation maps. Resting state EEG of TS patients treated with thalamic
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Effects of theta burst stimulation on reward processing and decision-making in bipolar disorder: A pilot study Brain Stimul. (IF 7.7) Pub Date : 2024-02-07 Ahmad Mayeli, Yiming Wang, Simona Graur, Merage Ghane, Ahmadreza Keihani, Allison Kim, Sabine Janssen, Chloe Huston, Brian A. Coffman, Fabio Ferrarelli, Mary L. Phillips
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1:2 entrainment is not a device-induced artefact, except when it is Brain Stimul. (IF 7.7) Pub Date : 2024-02-06 James J. Sermon, Moaad Benjaber, Benoit Duchet, Juan Anso, Maria Olaru, Philip A. Starr, Timothy Denison
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Identifying clinical predictors of response to repetitive transcranial magnetic stimulation for smoking cessation: Secondary analysis of a multicenter RCT Brain Stimul. (IF 7.7) Pub Date : 2024-02-02 Victor M. Tang, Laurie Zawertailo, Peter Selby, Abraham Zangen, Dhvani Mehta, Tony P. George, Bernard Le Foll, Kristina M. Gicas, Matthew E. Sloan, Scott Veldhuizen
Abstract not available
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Assessing cortical excitability with electroencephalography: A pilot study with EEG-iTBS Brain Stimul. (IF 7.7) Pub Date : 2024-01-27 Giovanni Pellegrino, Anna-Lisa Schuler, Zhengchen Cai, Daniele Marinazzo, Franca Tecchio, Lorenzo Ricci, Mario Tombini, Vincenzo di Lazzaro, Giovanni Assenza
Background Cortical excitability measures neural reactivity to stimuli, usually delivered via Transcranial Magnetic Stimulation (TMS). Excitation/inhibition balance (E/I) is the ongoing equilibrium between excitatory and inhibitory activity of neural circuits. According to some studies, E/I could be estimated in-vivo and non-invasively through the modeling of electroencephalography (EEG) signals and
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Direct subthalamic nucleus stimulation influences speech and voice quality in Parkinson's disease patients Brain Stimul. (IF 7.7) Pub Date : 2024-01-23 Marine Bobin, Neil Sulzer, Gina Bründler, Matthias Staib, Lukas L. Imbach, Lennart H. Stieglitz, Philipp Krauss, Oliver Bichsel, Christian R. Baumann, Sascha Frühholz
Background DBS of the subthalamic nucleus (STN) considerably ameliorates cardinal motor symptoms in PD. Reported STN-DBS effects on secondary dysarthric (speech) and dysphonic symptoms (voice), as originating from vocal tract motor dysfunctions, are however inconsistent with rather deleterious outcomes based on post-surgical assessments. Objective To parametrically and intra-operatively investigate
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Single threshold adaptive deep brain stimulation in Parkinson's disease depends on parameter selection, movement state and controllability of subthalamic beta activity Brain Stimul. (IF 7.7) Pub Date : 2024-01-22 Johannes L. Busch, Jonathan Kaplan, Jeroen G.V. Habets, Lucia K. Feldmann, Jan Roediger, Richard M. Köhler, Timon Merk, Katharina Faust, Gerd-Helge Schneider, Hagai Bergman, Wolf-Julian Neumann, Andrea A. Kühn
Background Deep brain stimulation (DBS) is an invasive treatment option for patients with Parkinson's disease. Recently, adaptive DBS (aDBS) systems have been developed, which adjust stimulation timing and amplitude in real-time. However, it is unknown how changes in parameters, movement states and the controllability of subthalamic beta activity affect aDBS performance. Objective To characterize how
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A user-friendly input–output curve analysis tool for variable direct responses to brain stimulation Brain Stimul. (IF 7.7) Pub Date : 2024-01-18 Ke Ma, Stephan M. Goetz
Abstract not available
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Deep brain stimulation device-specific artefacts in MEG recordings Brain Stimul. (IF 7.7) Pub Date : 2024-01-18 Bahne H. Bahners, Roxanne Lofredi, Tilmann Sander, Alfons Schnitzler, Andrea A. Kühn, Esther Florin
Abstract not available
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Cortico-cortical paired associative stimulation highlights asymmetrical communication between rostral premotor cortices and primary motor cortex Brain Stimul. (IF 7.7) Pub Date : 2024-01-06 Naomi Bevacqua, Sonia Turrini, Francesca Fiori, Chiara Saracini, Boris Lucero, Matteo Candidi, Alessio Avenanti
Abstract not available
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Treatment of Hallucinogen-Persisting Perception Disorder: A case report on repetitive transcranial magnetic stimulation targeting the right temporoparietal junction Brain Stimul. (IF 7.7) Pub Date : 2024-01-05 Sylvain Creton, Gaëlla Boulanger, Thomas Pereon, Jean-Marie Batail, Dominique Drapier
Abstract not available
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Vagus nerve stimulation for the treatment of narcolepsy Brain Stimul. (IF 7.7) Pub Date : 2024-01-04 Yaroslav Winter, Katharina Sandner, Claudio L.A. Bassetti, Martin Glaser, Dumitru Ciolac, Andreas Ziebart, Ali Karakoyun, Assel Saryyeva, Joachim K. Krauss, Florian Ringel, Sergiu Groppa
Background and objective No study on neurostimulation in narcolepsy is available until now. Arousal- and wake-promoting effects of vagus nerve stimulation (VNS) have been demonstrated in animal experiments and are well-known as side effects of VNS therapy in epilepsy and depression. The objective was to evaluate the therapeutic effect of VNS on daily sleepiness and cataplexies in narcolepsy. Methods
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Lessons from multitarget neurostimulation in isolated dystonia: Less is more? Brain Stimul. (IF 7.7) Pub Date : 2024-01-03 Marie-Charlotte Cuartero, David Grabli, Emmanuel Flamand-Roze, Carine Karachi, Tiphaine Rouaud, Pascal Derkinderen, Philippe Damier, Sylvie Raoul, Paul Krack, Elena Moro, Valérie Fraix, Stéphan Chabardès, Pierre Burbaud, Dominique Guehl, Emmanuel Cuny, Serge Pinto, Marie Vidailhet
Abstract not available
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Deep brain stimulation with short versus conventional pulse width in Parkinson's disease and essential tremor: A systematic review and meta-analysis Brain Stimul. (IF 7.7) Pub Date : 2023-12-29 Sara Smeets, Alexandra Boogers, Tine Van Bogaert, Jana Peeters, Myles McLaughlin, Bart Nuttin, Tom Theys, Wim Vandenberghe, Philippe De Vloo
Background To maximize clinical benefit and minimize stimulation-induced side effects, optimising deep brain stimulation (DBS) parameters is paramount. Recent literature suggests a potential benefit of short pulse width DBS (spDBS; ≤40 μs) over conventional pulse width DBS (cDBS; ≥60 μs) in movement disorders. Objective To compare therapeutic window (TW), therapeutic and side effects and energy consumption
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Medial forebrain bundle stimulation after failed subcallosal cingulate deep brain stimulation for treatment-resistant depression: Efficacy of a dual deep brain stimulation system for depression Brain Stimul. (IF 7.7) Pub Date : 2023-12-28 Amit R. Persad, Nicole R. Coote, Karen Waterhouse, Sara McLeod, Jonathan A. Norton, Layla Gould, Aleksander M. Vitali
Abstract not available
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Conversion of a medical implant into a versatile computer-brain interface Brain Stimul. (IF 7.7) Pub Date : 2023-12-24 Bálint Várkuti, László Halász, Saman Hagh Gooie, Gabriella Miklós, Ricardo Smits Serena, Gijs van Elswijk, Cameron C. McIntyre, Scott F. Lempka, Andres M. Lozano, Loránd Erōss
Background Information transmission into the human nervous system is the basis for a variety of prosthetic applications. Spinal cord stimulation (SCS) systems are widely available, have a well documented safety record, can be implanted minimally invasively, and are known to stimulate afferent pathways. Nonetheless, SCS devices are not yet used for computer-brain-interfacing applications. Objective
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Locus coeruleus tyrosine hydroxylase positive neurons mediated the peripheral and central therapeutic effects of transcutaneous auricular vagus nerve stimulation (taVNS) in MRL/lpr mice Brain Stimul. (IF 7.7) Pub Date : 2023-12-23 Hongjie Lv, Xiu Yu, Ping Wang, Mengxian Luo, Yijun Luo, Haimei Lu, Keer Wang, Anran Xi, Chengping Wen, Zhenghao Xu
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Pulse-width modulated temporal interference (PWM-TI) brain stimulation Brain Stimul. (IF 7.7) Pub Date : 2023-12-23 Charlotte E. Luff, Patrycja Dzialecka, Emma Acerbo, Adam Williamson, Nir Grossman
Background Electrical stimulation involving temporal interference of two different kHz frequency sinusoidal electric fields (temporal interference (TI)) enables non-invasive deep brain stimulation, by creating an electric field that is amplitude modulated at the slow difference frequency (within the neural range), at the target brain region. Objective Here, we investigate temporal interference neural
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Hearing safety of accelerated TMS: Calculating daily noise dose of the SAINT protocol for depression Brain Stimul. (IF 7.7) Pub Date : 2023-12-22 Bianca N. De, Brent R. Carr
Abstract not available
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Stereo-EEG-guided network modulation for psychiatric disorders: Interactive holographic planning Brain Stimul. (IF 7.7) Pub Date : 2023-12-20 Angela M. Noecker, Jeffrey Mlakar, Kelly R. Bijanki, Mark A. Griswold, Nader Pouratian, Sameer A. Sheth, Cameron C. McIntyre
Connectomic modeling studies are expanding understanding of the brain networks that are modulated by deep brain stimulation (DBS) therapies. However, explicit integration of these modeling results into prospective neurosurgical planning is only beginning to evolve. One challenge of employing connectomic models in patient-specific surgical planning is the inherent 3D nature of the results, which can
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Stereo-EEG-guided network modulation for psychiatric disorders: Surgical considerations Brain Stimul. (IF 7.7) Pub Date : 2023-12-20 Sameer A. Sheth, Ben Shofty, Anusha Allawala, Jiayang Xiao, Joshua A. Adkinson, Raissa K. Mathura, Victoria Pirtle, John Myers, Denise Oswalt, Nicole R. Provenza, Nisha Giridharan, Angela M. Noecker, Garrett P. Banks, Ron Gadot, Ricardo A. Najera, Adrish Anand, Ethan Devara, Huy Dang, Eleonora Bartoli, Andrew Watrous, Jeffrey Cohn, David Borton, Sanjay J. Mathew, Cameron C. McIntyre, Wayne Goodman
Deep brain stimulation (DBS) and other neuromodulatory techniques are being increasingly utilized to treat refractory neurologic and psychiatric disorders. /Hypothesis: To better understand the circuit-level pathophysiology of treatment-resistant depression (TRD) and treat the network-level dysfunction inherent to this challenging disorder, we adopted an approach of inpatient intracranial monitoring
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Transcranial focused ultrasound for the treatment of tremor: A preliminary case series Brain Stimul. (IF 7.7) Pub Date : 2023-12-19 C.M. Deveney, J.R. Surya, J.M. Haroon, K.D. Mahdavi, K.R. Hoffman, K.C. Enemuo, K.G. Jordan, S.A. Becerra, T. Kuhn, A. Bystristky, S.E. Jordan
Background Essential tremor (ET) can be debilitating. Treatments for ET include beta-blockers and surgical interventions. Low-intensity focused ultrasound (LIFU) may offer an office-based non-invasive alternative. Objective This pilot open label clinical trial explores safety, feasibility, and potential efficacy of LIFU in treatment of ET. Methods We report outcomes from the first 10 participants in
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Longitudinal resting-state network connectivity changes in electroconvulsive therapy patients compared to healthy controls Brain Stimul. (IF 7.7) Pub Date : 2023-12-13 Joey P.A.J. Verdijk, Laurens A. van de Mortel, Freek ten Doesschate, Julia C.M. Pottkämper, Sven Stuiver, Willem B. Bruin, Christopher C. Abbott, Miklos Argyelan, Olga T. Ousdal, Hauke Bartsch, Katherine Narr, Indira Tendolkar, Vince Calhoun, Joshua Lukemire, Ying Guo, Leif Oltedal, Guido van Wingen, Jeroen A. van Waarde
Objective Electroconvulsive therapy (ECT) is effective for major depressive episodes. Understanding of underlying mechanisms has been increased by examining changes of brain connectivity but studies often do not correct for test-retest variability in healthy controls (HC). In this study, we investigated changes in resting-state networks after ECT in a multicenter study. Methods Functional resting-state
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Altered in vivo early neurogenesis traits in patients with depression: Evidence from neuron-derived extracellular vesicles and electroconvulsive therapy Brain Stimul. (IF 7.7) Pub Date : 2023-12-13 Xin-hui Xie, Shu-xian Xu, Lihua Yao, Mian-mian Chen, Honghan Zhang, Chao Wang, Corina Nagy, Zhongchun Liu
Background The neurogenesis hypothesis is a promising candidate etiologic hypothesis for depression, and it is associated with electroconvulsive therapy (ECT). However, human in vivo molecular-level evidence is lacking. Objective We used neuron-derived extracellular vesicles (NDEVs) as a “window to the neurons” to explore the in vivo neurogenesis status associated with ECT in patients with treatment-resistant
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Intracranial beta activity is a biomarker of circadian and stimulation-induced arousal in obsessive compulsive disorder Brain Stimul. (IF 7.7) Pub Date : 2023-12-13 Joline M. Fan, Bianca De, Adam C. Frank, Genevieve Basich-Pease, Tenzin Norbu, Melanie A. Morrison, Paul Larson, Philip A. Starr, Andrew D. Krystal, A Moses Lee
Abstract not available
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The importance of acoustic output measurement and monitoring for the replicability of transcranial ultrasonic stimulation studies Brain Stimul. (IF 7.7) Pub Date : 2023-12-12 Miriam C Klein-Flügge, Elsa F Fouragnan, Eleanor Martin
Abstract not available