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Electroencephalography connectome changes in chronic insomnia disorder are correlated with neurochemical signatures Sleep (IF 5.6) Pub Date : 2024-03-23 Liyong Yu, Wei Peng, Wenting Lin, Yucai Luo, Daijie Hu, Guangli Zhao, Hao Xu, Zeyang Dou, Qi Zhang, Xiaojuan Hong, Siyi Yu
Study Objectives This study aimed to investigate the alterations in resting-state electroencephalography (EEG) global brain connectivity (GBC) in patients with chronic insomnia disorder (CID) and to explore the correlation between macroscale connectomic variances and microscale neurotransmitter distributions. Methods We acquired 64-channel EEG from 35 female CID patients and 34 healthy females. EEG
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Thermoneutral Temperature Exposure Enhances Slow Wave Sleep with a Correlated Improvement in Amyloid Pathology in a Triple-Transgenic Mouse Model of Alzheimer’s Disease Sleep (IF 5.6) Pub Date : 2024-03-21 J Wang, D Huffman, A Ajwad, C J McLouth, A Bachstetter, K Kohler, M P Murphy, B F O’Hara, M J Duncan, S Sunderam
Accumulation of amyloid-β (Aβ) plays an important role in Alzheimer’s disease (AD) pathology. There is growing evidence that disordered sleep may accelerate AD pathology by impeding the physiological clearance of Aβ from the brain that occurs in normal sleep. Therapeutic strategies for improving sleep quality may therefore help slow disease progression. It is well documented that the composition and
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EEG rhythmic and arrhythmic spectral components and functional connectivity at resting state may predict the development of synucleinopathies in idiopathic REM sleep behavior disorder Sleep (IF 5.6) Pub Date : 2024-03-18 J Hernandez, J-M Lina, J Dubé, A Lafrenière, J-F Gagnon, J-Y Montplaisir, R B Postuma, J Carrier
Study Objectives Idiopathic/isolated REM-sleep behavior disorder (iRBD) often precedes the onset of synucleinopathies. Here, we investigated whether baseline resting-state EEG advanced spectral power and functional connectivity differ between iRBD patients who converted towards a synucleinopathy at follow-up and those who did not. Methods Eighty-one participants with iRBD (66.89±6.91 years) underwent
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EEG Spectro-Spatial Covariance Patterns Related to Phenoconversion in Isolated REM Sleep Behavior Disorder and Their Longitudinal Trajectories in α-Synucleinopathies Sleep (IF 5.6) Pub Date : 2024-03-12 Kyoungeun Park, Jung Hwan Shin, Jung-Ick Byun, El Jeong, Han-Joon Kim, Ki-Young Jung
Study Objectives This study aimed to identify electroencephalographic (EEG) spectro-spatial covariance patterns associated with phenoconversion in isolated rapid eye movement sleep behavior disorder (iRBD) patients and explore their longitudinal trajectories within α-synucleinopathies. Methods We assessed 47 participants, including 35 iRBD patients and 12 healthy controls (HC), through baseline eye-closed
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Spindle-slow wave coupling and problem-solving skills: Impact of age Sleep (IF 5.6) Pub Date : 2024-03-11 D Baena, B Toor, N H van den Berg, L B Ray, S M Fogel
We examined how aging affects the role of sleep in the consolidation of newly learned cognitive strategies. Forty healthy young adults (20-35 years) and 30 healthy older adults (60-85 years) were included. Participants were trained on the Tower of Hanoi (ToH) task, then, half of each age group were assigned to either the 90-minute nap condition, or stayed awake, before retesting. The temporal co-occurrence
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Sleep Slow Oscillation-Spindle Coupling Precedes Spindle-Ripple Coupling During Development Sleep (IF 5.6) Pub Date : 2024-03-07 Julia Fechner, María P Contreras, Candela Zorzo, Xia Shan, Jan Born, Marion Inostroza
Study Objectives Sleep supports systems memory consolidation through the precise temporal coordination of specific oscillatory events during slow-wave sleep (SWS), i.e., the neocortical slow oscillations (SOs), thalamic spindles, and hippocampal ripples. Beneficial effects of sleep on memory are also observed in infants, although the contributing regions, especially hippocampus and frontal cortex,
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Most dynorphin neurons in the zona incerta-perifornical area are active in waking relative to NREM and REM sleep Sleep (IF 5.6) Pub Date : 2024-03-06 Priyattam J Shiromani, Aurelio Vidal-Ortiz
Dynorphin is an endogenous opiate localized in many brain regions and spinal cord, but the activity of dynorphin neurons during sleep is unknown. Dynorphin is an inhibitory neuropeptide that is coreleased with orexin, an excitatory neuropeptide. We use microendoscopy to test the hypothesis that, like orexin, the dynorphin neurons are wake-active. Dynorphin-cre mice (n=3) were administered rAAV8-Ef1a-Con/Foff
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Actigraphic sleep dimensions and associations with academic functioning among adolescents Sleep (IF 5.6) Pub Date : 2024-03-05 Gina Marie Mathew, David A Reichenberger, Lindsay Master, Orfeu M Buxton, Anne-Marie Chang, Lauren Hale
Study Objectives There is mixed evidence regarding associations of sleep duration with academic functioning in adolescents and a lack of research on other sleep dimensions, particularly using objective sleep measures. We examined associations of multiple actigraphic sleep dimensions with academic functioning among adolescents. Methods Data were from the sleep sub-study of the age 15 wave of the Future
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An online behavioural self-help intervention rapidly improves acute insomnia severity and subjective mood during the COVID-19 pandemic: a stratified randomised controlled trial Sleep (IF 5.6) Pub Date : 2024-03-02 Greg J Elder, Nayantara Santhi, Amelia R Robson, Pamela Alfonso-Miller, Kai Spiegelhalder, Jason G Ellis
Study Objectives Stressful life events, such as the COVID-19 pandemic, can cause acute insomnia. Cognitive behavioural therapy for acute insomnia is effective but is both time and resource-intensive. This study investigated if an online behavioural self-help intervention, which has been successfully used alongside sleep restriction for acute insomnia, reduced insomnia severity and improved mood in
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Psychiatric comorbidities and prescribing tendencies of sleep medications and related medications in young people with insomnia: A United States commercial claims-based analysis Sleep (IF 5.6) Pub Date : 2024-03-02 Greta Bushnell, Anna Ivanenko, Daniel B Horton, Jessica R Lunsford-Avery, Jonathan Posner, Tobias Gerhard, Elizabeth Suarez, Mark Olfson
Study Objectives To characterize children and youth newly diagnosed with insomnia and to describe their use of sleep and other related prescription medications. Methods Within a commercial claims database (1/1/2016-12/31/2021), we identified children and youth (2-24 years) with a newly recorded insomnia diagnosis (G47.0x;F51.0x) and examined psychiatric diagnoses in the prior 6 months. We evaluated
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Changes in electroencephalographic microstates between evening and morning are associated with overnight sleep slow waves in healthy individuals Sleep (IF 5.6) Pub Date : 2024-02-28 Ahmadreza Keihani, Ahmad Mayeli, Francesco Donati, Sabine A Janssen, Chloe A Huston, Rebekah M Colacot, Obada Al Zoubi, Michael Murphy, Fabio Ferrarelli
Study Objectives Microstates are semi-stable voltage topographies that account for most of electroencephalogram (EEG) variance. However, the impact of time of the day and sleep on microstates has not been examined. To address this gap, we assessed whether microstates differed between the evening and morning and whether sleep slow waves correlated with microstate changes in healthy participants. Methods
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Intensive support does not improve PAP use in Spinal Cord injury/disease: A randomized clinical trial Sleep (IF 5.6) Pub Date : 2024-02-28 M Safwan Badr, Jennifer L Martin, Abdulghani Sankari, Salam Zeineddine, Anan Salloum, M Kristina Henzel, Kingman Strohl, Afifa Shamim-Uzzaman, Anna M May, Constance H Fung, Nishtha Pandya, Sean Carroll, Michael N Mitchell
Objective Treatment of sleep-disordered breathing (SDB) with positive airway pressure (PAP) therapy has unique clinical challenges in individuals living with spinal cord injuries and diseases (SCI/D). Interventions focused on increasing PAP use have not been studied in this population. We aimed to evaluate the benefits of a program to increase PAP use among Veterans with SCI/D and SDB. Methods Randomized
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EEG slowing during REM sleep in older adults with subjective cognitive impairment and mild cognitive impairment Sleep (IF 5.6) Pub Date : 2024-02-23 Aaron Kin Fu Lam, James Carrick, Chien-Hui Kao, Craig L Phillips, Yi Zhong Zheng, Brendon J Yee, Jong Won Kim, Ronald R Grunstein, Sharon L Naismith, Angela L D’Rozario
Study Objectives In older adults with Alzheimer’s disease, slowing of electroencephalographic (EEG) activity during REM sleep has been observed. Few studies have examined EEG slowing during REM in those with mild cognitive impairment (MCI) and none have examined its relationship with cognition in this at-risk population. Methods 210 older adults (mean age = 67.0, sd = 8.2 years) underwent comprehensive
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Sleep-wake behavioral characteristics associated with depression symptoms: Findings from the Multi-Ethnic Study of Atherosclerosis Sleep (IF 5.6) Pub Date : 2024-02-23 Stephen C L Lau, Gehui Zhang, Michael Rueschman, Xiaoyu Li, Michael R Irwin, Robert T Krafty, William V McCall, Elizabeth Skidmore, Sanjay R Patel, Susan Redline, Stephen F Smagula
Study Objectives To help prioritize target/groups for experimental intervention studies, we characterized cross-sectional associations between 24-hour sleep/wake measures and depression symptoms; and evaluated if similar sleep/wake-depression relationships existed in people with and without higher insomnia severity. Methods Participants had ≥3 days of actigraphy data (n=1884; mean age=68.6/SD=9.1;
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Evaluating a Novel 24-Hour Rest/Activity Rhythm Marker of Preclinical β-Amyloid Deposition Sleep (IF 5.6) Pub Date : 2024-02-21 Adam P Spira, Fangyu Liu, Vadim Zipunnikov, Murat Bilgel, Jill A Rabinowitz, Yang An, Junrui Di, Jiawei Bai, Sarah K Wanigatunga, Mark N Wu, Brendan P Lucey, Jennifer A Schrack, Amal A Wanigatunga, Paul B Rosenberg, Eleanor M Simonsick, Keenan A Walker, Luigi Ferrucci, Susan M Resnick
Study Objectives To compare sleep and 24-hour rest/activity rhythms (RARs) between cognitively normal older adults who are β-amyloid-positive (Aβ or Aβ- and replicate a novel time-of-day-specific difference between these groups identified in a previous exploratory study. Methods We studied 82 cognitively normal participants from the Baltimore Longitudinal Study of Aging (aged 75.7 ±8.5 years, 55% female
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Data-Driven, Generalizable Prediction of Adolescent Sleep Disturbances in the Multisite ABCD Study Sleep (IF 5.6) Pub Date : 2024-02-17 Katherine L McCurry, Katherine Toda-Thorne, Aman Taxali, Mike Angstadt, Felicia A Hardi, Mary M Heitzeg, Chandra Sripada
Study Objectives Sleep disturbances are common in adolescence and associated with a host of negative outcomes. Here we assess associations between multifaceted sleep disturbances and a broad set of psychological, cognitive, and demographic variables using a data-driven approach, canonical correlation analysis (CCA). Methods Baseline data from 9,093 participants from the Adolescent Brain Cognitive Development℠
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Tracked and self-reported nighttime smartphone use, general health, and healthcare utilization: results from the SmartSleep Study Sleep (IF 5.6) Pub Date : 2024-02-13 Henning Johannes Drews, Christoffer Sejling, Thea Otte Andersen, Tibor V Varga, Andreas Kryger Jensen, Naja Hulvej Rod
Study Objectives Nighttime smartphone use is an increasing public health concern. We investigated whether nighttime smartphone use is associated with general health and primary healthcare utilization. Methods 4,520 individuals (age 35.6 ± 9.7 years, 35% male) provided self-reported information on smartphone use frequency, symptoms of depression, and general health (one-item perceived health and cross-symptom
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Medication-Induced Central Sleep Apnea: A Unifying Concept Sleep (IF 5.6) Pub Date : 2024-02-09 Shahrokh Javaheri, W J Randerath, M Safwan Badr, Sogol Javaheri
Medication-induced central sleep apnea (CSA) is one of the 8 categories of causes of CSA but in the absence of awareness and careful history may be misclassified as primary CSA. While opioids are a well-known cause of respiratory depression and CSA, non-opioids medications including sodium oxybate, baclofen, valproic acid, gabapentin and ticagrelor are less well-recognized. Opioids-induced respiratory
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EEG-based Machine Learning Models for the Prediction of Phenoconversion Time and Subtype in iRBD Sleep (IF 5.6) Pub Date : 2024-02-08 El Jeong, Yong Woo Shin, Jung-Ick Byun, Jun-Sang Sunwoo, Monica Roascio, Pietro Mattioli, Laura Giorgetti, Francesco Famà, Gabriele Arnulfo, Dario Arnaldi, Han-Joon Kim, Ki-Young Jung
Study Objectives Idiopathic/Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of α-synucleinopathies and eventually phenoconverts to overt neurodegenerative diseases including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Associations of baseline resting-state electroencephalography (EEG) with phenoconversion have been reported
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Daily light exposure profiles and the association with objective sleep quality in patients with Parkinson’s disease: The PHASE study Sleep (IF 5.6) Pub Date : 2024-02-08 Kenji Obayashi, Keigo Saeki, Yoshiaki Tai, Yuki Yamagami, Yuichi Esaki, Tadanobu Yoshikawa, Kazuma Sugie, Hiroshi Kataoka
Study Objectives Light information crucially influences the sleep initiation and continuity. The purpose of this study was to compare daily light exposure between patients with Parkinson’s disease (PD) and non-PD older adults and evaluate the association of daily light exposure with objective sleep measures in patients with PD. Methods In this cross-sectional study of 189 outpatients with PD and 1101
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Polysomnographic characteristics of excessive daytime sleepiness phenotypes in obstructive sleep apnea: Results from the international Sleep Apnea Global Interdisciplinary Consortium (SAGIC) Sleep (IF 5.6) Pub Date : 2024-02-05 Elin H Thorarinsdottir, Allan I Pack, Thorarinn Gislason, Samuel T Kuna, Thomas Penzel, Qing Yun Li, Peter A Cistulli, Ulysses J Magalang, Nigel McArdle, Bhajan Singh, Christer Janson, Thor Aspelund, Magdy Younes, Philip de Chazal, Sergio Tufik, Brendan T Keenan
Study objectives Excessive daytime sleepiness (EDS) is a major symptom of obstructive sleep apnea (OSA). Traditional polysomnographic (PSG) measures only partially explain EDS in OSA. This study analyzed traditional and novel PSG characteristics of two different measures of EDS among OSA patients. Methods Sleepiness was assessed using the Epworth Sleepiness Scale (>10 points defined as “risk of dozing”)
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The Natural History of Insomnia: Evaluating illness severity from acute to chronic insomnia; Is the first the worst? Sleep (IF 5.6) Pub Date : 2024-02-04 Julia T Boyle, Knashawn H Morales, Alexandria Muench, Jason Ellis, Ivan Vargas, Michael A Grandner, Donn Posner, Michael L Perlis
Study Objectives The 3P and 4P models represent illness severity over the course of insomnia disorder. The 3P model suggests that illness severity is worst during acute onset. The 4P model suggests that illness severity crescendos with chronicity. The present analysis from an archival dataset assesses illness severity with new onset illness (i.e., from good sleep [GS] to acute insomnia [AI] to chronic
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A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice Sleep (IF 5.6) Pub Date : 2024-02-03 Chia-Luen Leu, Daniel D Lam, Aaro V Salminen, Benedikt Wefers, Lore Becker, Lillian Garrett, Jan Rozman, Wolfgang Wurst, Martin Hrabě de Angelis, Sabine M Hölter, Juliane Winkelmann, Rhîannan H Williams
Restless legs syndrome (RLS) is a neurological disorder characterized by uncomfortable or unpleasant sensations in the legs during rest periods. To relieve these sensations, patients move their legs, causing sleep disruption. While the pathogenesis of RLS has yet to be resolved, there is a strong genetic association to the MEIS1 gene. A missense variant in MEIS1 is enriched 7-fold in RLS patients compared
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Insomnia is more likely to persist than remit after a time of stress and uncertainty: A longitudinal cohort study examining trajectories and predictors of insomnia symptoms Sleep (IF 5.6) Pub Date : 2024-02-02 Hailey Meaklim, Flora Le, Sean P A Drummond, Sukhjit K Bains, Prerna Varma, Moira F Junge, Melinda L Jackson
Study Objectives The study aimed to characterise insomnia symptom trajectories over 12 months during a time of stress and uncertainty, the COVID-19 pandemic. It also aimed to investigate sleep and psychological predictors of persistent insomnia symptoms. Methods This longitudinal cohort study comprised 2069 participants with and without insomnia symptoms during the first year of the pandemic. Participants
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Latency To N3 Interruption In Arousal Disorders Sleep (IF 5.6) Pub Date : 2024-02-02 C Perretti, A Gales, S Leu-Semenescu, P Dodet, C Bianquis, E Groos, M Puligheddu, J B Maranci, I Arnulf
Study objectives To help expert witnesses in criminal cases using the “sleepwalking defense”, we studied the time of first and last interruptions from stage N3 in patients with arousal disorders, including sexsomnia, as well as their determinants. Methods The epochs of lights off, sleep onset, first N3 interruption (with and without behaviors), and last N3 interruption were determined by videopolysomnography
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Sleep as a prognostic factor in low back pain: a systematic review of prospective cohort studies and secondary analyses of randomized controlled trials Sleep (IF 5.6) Pub Date : 2024-02-01 Samuel Silva, Jill A Hayden, Gabriel Mendes, Arianne Verhagen, Rafael Zambelli Pinto, Andressa Silva
Sleep problems are common in individuals with low back pain (LBP) and sleep restriction seems to be associated with impaired pain processing. Our objective was to investigate whether sleep is associated with future LBP outcomes (i.e., pain intensity, disability, and recovery) in adults. We conducted a systematic review of prospective cohort studies and secondary analyses of randomized controlled trials
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Short-Term Stability and Night-to-Night Variability of Sleep Parameters in Nightmares Comorbid with Chronic Insomnia Disorder Across Multiple Nights of Polysomnography Sleep (IF 5.6) Pub Date : 2024-02-01 Caitlin Paquet, Kristina P Lenker, Susan L Calhoun, Edward O Bixler, Alexandros N Vgontzas, Julio Fernandez-Mendoza
Study Objectives The purpose of this study was to examine the degree of short-term stability of polysomnographic (PSG) measured sleep parameters and the overall differences between individuals with comorbid nightmares and insomnia compared to those with chronic insomnia disorder alone or good sleeping controls across four nights in the sleep lab. Methods A total of 142 good sleeping controls, 126 chronic
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Adaptive changes in BMAL2 with increased locomotion associated with the evolution of unihemispheric slow-wave sleep in mammals Sleep (IF 5.6) Pub Date : 2024-01-30 Daiqing Yin, Biao Zhang, Yujie Chong, Wenhua Ren, Shixia Xu, Guang Yang
Marine mammals, especially cetaceans, have evolved a very special form of sleep characterized by unihemispheric slow-wave sleep (USWS) and a negligible amount or complete absence of rapid-eye-movement (REM) sleep; however, the underlying genetic mechanisms remain unclear. Here, we detected unique, significant selection signatures in basic helix-loop-helix ARNT like 2 (BMAL2; also called ARNTL2), a
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Suvorexant alters dynamics of the sleep-EEG power spectrum and depressive symptom trajectories during inpatient opioid withdrawal Sleep (IF 5.6) Pub Date : 2024-01-26 Matthew J Reid, Kelly E Dunn, Liza Abraham, Jennifer Ellis, Carly Hunt, Charlene E Gamaldo, William G Coon, Chung Jung Mun, Eric C Strain, Michael T Smith, Patrick H Finan, Andrew S Huhn
Study Objectives Opioid withdrawal is an aversive experience that often exacerbates depressive symptoms and poor sleep. The aims of the present study were to examine the effects suvorexant on oscillatory sleep-EEG band power during medically managed opioid withdrawal, and to examine their association with withdrawal severity and depressive symptoms. Methods Participants with OUD (N=38: age-range:21-63
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Racial/Ethnic Disparities in the Trajectories of Insomnia Symptoms from Childhood to Young Adulthood Sleep (IF 5.6) Pub Date : 2024-01-25 Rupsha Singh, Raegan Atha, Kristina P Lenker, Susan L Calhoun, Jiangang Liao, Fan He, Alexandros N Vgontzas, Duanping Liao, Edward O Bixler, Chandra L Jackson, Julio Fernandez-Mendoza
Study Objectives To examine differences in the longitudinal prevalence of childhood insomnia symptoms across Black/African American, Hispanic/Latinx, and non-Hispanic White groups. Methods Participants were 519 children from the Penn State Child Cohort (baseline (V1) from 2000-2005) who were followed up 8 years later as adolescents (V2) and 15 years later as young adults (S3). Mean age at S3 was 24
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Sleep disturbance and suicidal ideation mediated by psychotic-like experiences in adolescents: a two-wave longitudinal study Sleep (IF 5.6) Pub Date : 2024-01-17 Luowei Bu, Dongfang Wang, Yunge Fan, Haoxian Ye, Wenxu Liu, Fang Fan
Study Objectives Sleep disturbance may cause suicidal ideation (SI). This study aimed to examine their co-occurrence rate among adolescents and investigate whether psychotic-like experiences (PLEs) mediate this association. Methods A total of 17,722 Chinese adolescents were included in this two-wave longitudinal study. The baseline survey (Time 1, T1) was conducted between April 21 and May 12, 2021
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Downregulation of hypocretin/orexin after H1N1 Pandemrix vaccination of adolescent mice Sleep (IF 5.6) Pub Date : 2024-01-16 Nicolai Pagh-Berendtsen, Artem Pavlovskyi, Danel Flores Tellez, Christine Egebjerg, Mie Gunni Kolmos, Jessica Justinussen, Birgitte Rahbek Kornum
Narcolepsy type 1 (NT1), characterized by the loss of hypocretin/orexin (HCRT) production in the lateral hypothalamus, has been linked to Pandemrix vaccination during the 2009 H1N1 pandemic especially in children and adolescents. It is still unknown why this vaccination increased the risk of developing NT1. This study investigated the effects of Pandemrix vaccination during adolescence on Hcrt mRNA
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Neurobehavioural functions during recurrent periods of sleep restriction: effects of intraindividual variability in sleep duration Sleep (IF 5.6) Pub Date : 2024-01-12 Tiffany B Koa, Joshua J Gooley, Michael W L Chee, June C Lo
Study Objectives To investigate whether neurobehavioural impairments are exacerbated during successive cycles of sleep restriction and recovery in young adults, and whether a variable short sleep schedule can mitigate these impairments relative to a stable one. Methods Fifty-two healthy young adults (25 males, age: 21-28) were randomly assigned to the stable short sleep group, the variable short sleep
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Altered sleep architecture following consecutive nights of pre-sleep alcohol Sleep (IF 5.6) Pub Date : 2024-01-11 Katie S McCullar, David H Barker, John E McGeary, Jared M Saletin, Caroline Gredvig-Ardito, Robert M Swift, Mary A Carskadon
Study Objectives Alcohol consumption before sleep decreases sleep latency, explaining the common use of alcohol as a sleep aid. The full impact of alcohol on sleep architecture is not well understood, particularly the potential cumulative effects of pre-sleep alcohol consumption across consecutive nights. Here, we describe the effects of pre-sleep alcohol on sleep architecture across three consecutive
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Narcolepsy Severity Scale-2 and Idiopathic Hypersomnia Severity Scale to better quantify symptoms severity and consequences in Narcolepsy type 2 Sleep (IF 5.6) Pub Date : 2024-01-10 Lucie Barateau, Sofiene Chenini, Claire Denis, Quentin Lorber, Séverine Béziat, Isabelle Jaussent, Yves Dauvilliers
Study Objectives Narcolepsy type 2 (NT2) is an understudied central disorder of hypersomnolence sharing some similarities with narcolepsy type 1 (NT1) and idiopathic hypersomnia (IH). We aimed: (1) to assess systematically the symptoms in patients with NT2, with self-reported questionnaires: Epworth sleepiness scale (ESS), Narcolepsy Severity Scale (NSS), IH Severity Scale (IHSS), and (2) to evaluate
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The Application of Machine Learning on Brain Imaging Features of Different Narcolepsy Subtypes Sleep (IF 5.6) Pub Date : 2024-01-06 Wei-Chih Chin, Sheng-Yao Huang, Feng-Yuan Liu, Chih-Huan Wang, I Tang, Ing-Tsung Hsiao, Yu-Shu Huang
Study objectives Narcolepsy is a central hypersomnia disorder, and differential diagnoses between its subtypes can be difficult. Hence, we applied machine learning to analyze the positron emission tomography (PET) data of patients with type 1 or type 2 narcolepsy, and patients with type 1 narcolepsy and comorbid schizophrenia, to construct predictive models to facilitate the diagnosis. Methods This
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The Effect of Total Sleep Deprivation on Working Memory: Evidence from Diffusion Model Sleep (IF 5.6) Pub Date : 2024-01-05 Jiahui Li, Yixuan Cao, Simei Ou, Tianxiang Jiang, Ling Wang, Ning Ma
Study objective Working memory is crucial in human daily life and is vulnerable to sleep loss. The current study investigated the impact of sleep deprivation on working memory from the information processing perspective, to explore whether sleep deprivation affects the working memory via impairing information manipulation. Methods Thirty-seven healthy adults attended two counterbalanced protocols:
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The interrelationships between sleep regularity, obstructive sleep apnea and hypertension in a middle-aged community population Sleep (IF 5.6) Pub Date : 2024-01-05 Kelly Sansom, Amy Reynolds, Daniel Windred, Andrew Phillips, Satvinder S Dhaliwal, Jennifer Walsh, Kathleen Maddison, Bhajan Singh, Peter Eastwood, Nigel McArdle
Study Objectives Little is known about the inter-relationships between sleep regularity, obstructive sleep apnea (OSA) and important health markers. This study examined whether irregular sleep is associated with OSA and hypertension, and if this modifies the known association between OSA and hypertension. Methods 602 adults (age mean(SD) =56.96(5.51) years, female=60%) from the Raine Study who were
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Identification of bidirectional causal links between gut microbiota and narcolepsy type 1 using Mendelian randomization Sleep (IF 5.6) Pub Date : 2024-01-04 Dandan Sheng, Peihong Li, Zheng Xiao, Xinru Li, Jing Liu, Bo Xiao, Weiping Liu, Luo Zhou
Study Objectives Narcolepsy type 1 (NT1), characterized by cataplexy and orexin deficiency, is a rare and frequently debilitating neurological disorder. It has been noted to have connections with the gut microbiota, yet the exact causal relationships remain unclear. Methods We conducted a comprehensive bidirectional Mendelian randomization (MR) study to rigorously investigate the causal links between
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Disrupted topological properties of structural brain networks present a glutamatergic neuropathophysiology in people with narcolepsy Sleep (IF 5.6) Pub Date : 2024-01-04 Guoyan Chen, Wen Wang, Haoyang Wu, Xiangchao Zhao, Xiaopeng Kang, Jiafeng Ren, Jun Zhang, Jiaxiu He, Shihui Sun, Zhao Zhong, Danqing Shang, Mengmeng Fan, Jinxiang Cheng, Dan Zhang, Changjun Su, Jiaji Lin
Study objectives Growing evidences have documented various abnormalities of the white matter bundles in people with narcolepsy. We sought to evaluate topological properties of brain structural networks, and their association with symptoms and neuropathophysiological features in people with narcolepsy. Methods Diffusion tensor imaging (DTI) was conducted for people with narcolepsy (n = 30) and matched
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Effect of chronic intermittent hypoxia on ocular and intraoral mechanical allodynia mediated via the calcitonin gene-related peptide in a rat Sleep (IF 5.6) Pub Date : 2024-01-02 Ayano Katagiri, Saki Kishimoto, Yoshie Okamoto, Masaharu Yamada, Hitoshi Niwa, David A Bereiter, Takafumi Kato
Study Objectives Obstructive sleep apnea, a significant hypoxic condition, may exacerbate several orofacial pain conditions. The study aims to define the involvement of calcitonin gene-related peptide (CGRP) in peripheral and central sensitization and in evoking orofacial mechanical allodynia under chronic intermittent hypoxia (CIH). Methods Male rats were exposed to CIH. Orofacial mechanical allodynia
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State of the Science and Recommendations for Using Wearable Technology in Sleep and Circadian Research Sleep (IF 5.6) Pub Date : 2023-12-27 Massimiliano de Zambotti, Cathy Goldstein, Jesse Cook, Luca Menghini, Marco Altini, Philip Cheng, Rebecca Robillard
Wearable sleep-tracking technology is of growing use in the sleep and circadian fields, including for applications across other disciplines, inclusive of a variety of disease states. Patients increasingly present sleep data derived from their wearable devices to their providers and the ever-increasing availability of commercial devices and new-generation research/clinical tools has led to the wide
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Longitudinally-assessed maternal sleep position, measures of breathing during sleep, and fetal growth in high-risk pregnancies Sleep (IF 5.6) Pub Date : 2023-12-18 Juliana Katz, Laura Sanapo, Margaret H Bublitz, Melissa Guillen, Ashanti Avalos, Annaly Aldana, Danielle Wilson, Ghada Bourjeily
Study Objectives Subjective recall of supine sleep during pregnancy has been linked to increased risk of stillbirth, but longitudinal, objective data are lacking. We aimed to examine how sleep position and breathing parameters change throughout pregnancy, and investigated associations between maternal supine sleep, assessed objectively in early and late gestation, and fetal growth velocity in high-risk
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Awake at the Wheel: How Auto Technology Innovations Present Ongoing Sleep Challenges and New Safety Opportunities Sleep (IF 5.6) Pub Date : 2023-12-18 Mark R Rosekind, Jeffrey P Michael, Zachariah L Dorey-Stein, Nathaniel F Watson
Individuals and society are dependent on transportation. Individuals move about their world for work, school, healthcare, social activities, religious and athletic events, and so much more. Society requires the movement of goods, food, medicine, etc. for basic needs, commerce, cultural and political exchanges, and all of its dynamic, complex elements. To meet these critical daily demands, the transportation
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Sustained polyphasic sleep restriction abolishes human growth hormone release Sleep (IF 5.6) Pub Date : 2023-12-16 Yevgenia Rosenblum, Frederik D Weber, Michael Rak, Zsófia Zavecz, Nicolas Kunath, Barbara Breitenstein, Björn Rasch, Marcel Zeising, Manfred Uhr, Axel Steiger, Martin Dresler
Study Objectives Voluntary sleep restriction is a common phenomenon in industrialized societies aiming to increase time spent awake and thus productivity. We explored how restricting sleep to a radically polyphasic schedule affects neural, cognitive, and endocrine characteristics. Methods Ten young healthy participants were restricted to one 20-min nap opportunity at the end of every 4 hours (i.e.
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Multivariate genome-wide association study of sleep health demonstrates unity and diversity Sleep (IF 5.6) Pub Date : 2023-12-16 Claire L Morrison, Evan A Winiger, Kenneth P Wright, Naomi P Friedman
There has been a recent push to focus sleep research less on disordered sleep and more on the dimensional sleep health. Sleep health incorporates several dimensions of sleep: chronotype, efficiency, daytime alertness, duration, regularity, and satisfaction with sleep. A previous study demonstrated sleep health domains correlate only moderately with each other at the genomic level (|rGs|= .11-.51) and
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Circadian blood pressure dysregulation in children with obstructive sleep apnea Sleep (IF 5.6) Pub Date : 2023-12-14 Md Tareq Ferdous Khan, David F Smith, Christine L Schuler, Abigail M Witter, Mark W DiFrancesco, Keren Armoni Domany, Raouf S Amin, Md Monir Hossain
Study Objectives Obstructive sleep apnea (OSA) adversely affects normal blood pressure (BP) and may disrupt circadian BP patterns. We sought to examine 24-hour circadian BP rhythms in children with OSA and healthy controls. Methods Children 5–14 years with OSA and healthy controls underwent 24-hour BP monitoring and actigraphy to quantify sleep. Shape invariant statistical models compared circadian
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High Levels of Sleep Disturbance across Early Childhood Increases Cardiometabolic Disease Risk Index in Early Adolescence: Longitudinal Sleep Analysis Using the HOME Study Sleep (IF 5.6) Pub Date : 2023-12-14 Kara Mc Rae Duraccio, Yingying Xu, Dean W Beebe, Bruce Lanphear, Aimin Chen, Joseph M Braun, Heidi Kalkwarf, Kim M Cecil, Kimberly Yolton
Study Objectives This study examines the impact of sleep duration, bedtime, and sleep disturbance during early childhood on the risk of cardiometabolic disorder (CMD) in early adolescence. Methods Within the Health Outcomes and Measures of Environment (HOME) Study, we examined sleep patterns of 330 children from ages 2 to 8 years and the relationship of these sleep patterns with cardiometabolic risk
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Sleep Deprivation Alters Pubertal Timing in Humans and Rats: The Role of the Gut Microbiome Sleep (IF 5.6) Pub Date : 2023-12-09 Shirley Priscilla Gunawan, Shih-Yi Huang, Chun-Chi Wang, Linh Ba Phuong Huynh, Nam Nhat Nguyen, Shih-Yuan Hsu, Yang-Ching Chen
Study Objectives Evidence implied that sleeping duration is associated with the timing of puberty and that sleep deprivation triggers early pubertal onset in adolescents. Sleep deprivation can affect metabolic changes and gut microbiota composition. This study investigated the effects of sleep deprivation on pubertal onset and gut microbiota composition in animal models and a human cohort. Methods
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Sleep and insulin sensitivity in adolescents at risk of type 2 diabetes: the Sleep Manipulation in Adolescents at Risk of Type 2 Diabetes (SMART2D)randomized crossover study Sleep (IF 5.6) Pub Date : 2023-12-07 Caroline Dutil, Irina Podinic, Ryan B Featherstone, Amelia Eaton, Christin M Sadler, Gary S Goldfield, Stasia Hadjiyannakis, Reut Gruber, Mark S Tremblay, Denis Prud’homme, Jean-Philippe Chaput
Study Objectives To investigate the effect of increasing sleep duration for 1 week, compared to a week of habitual and decreased sleep, on insulin sensitivity(IS) in adolescents at risk for type 2 diabetes(T2D). Methods Adolescents, 13-18y old, at risk for T2D, with obesity and other risk factors, were recruited for a randomized(1:1), open-label, sex-stratified crossover study, that manipulated time-in-bed
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Associations between actigraphy-measured sleep duration, continuity, and timing with mortality in the UK Biobank Sleep (IF 5.6) Pub Date : 2023-12-05 Pedro F Saint-Maurice, Joshua R Freeman, Daniel Russ, Jonas S Almeida, Marissa M Shams-White, Shreya Patel, Dana L Wolff-Hughes, Eleanor L Watts, Erikka Loftfield, Hyokyoung G Hong, Steven C Moore, Charles E Matthews
study objectives To examine the associations between sleep duration, continuity, timing, and mortality using actigraphy among adults. Methods Data were from a cohort of 88,282 adults (40-69yrs) in UK Biobank that wore a wrist-worn triaxial accelerometer for 7-days. Actigraphy data were processed to generate estimates of sleep duration and other sleep characteristics including wake after sleep onset
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Studying Sleep: Towards the Identification of Hypnogram Features that Drive Expert Interpretation Sleep (IF 5.6) Pub Date : 2023-12-01 Caspar van der Woerd, Hans van Gorp, Sylvie Dujardin, Manuel Sastry, Humberto Garcia Caballero, Fokke van Meulen, Stef van den Elzen, Sebastiaan Overeem, Pedro Fonseca
Study Objectives Hypnograms contain a wealth of information and play an important role in sleep medicine. However, interpretation of the hypnogram is a difficult task and requires domain knowledge and “clinical intuition”. This study aimed to uncover which features of the hypnogram drive interpretation by physicians. In other words, make explicit which features physicians implicitly look for in hypnograms
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Multimodal Integration of Sleep Electroencephalogram, Brain Imaging and Cognitive Assessments: Approaches using Noisy Clinical Data. Sleep (IF 5.6) Pub Date : 2023-11-29 Diego R Mazzotti
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Can Intraoral And Facial Photos Predict Obstructive Sleep Apnea In The General And Clinical Population? Sleep (IF 5.6) Pub Date : 2023-11-29 Tatiana A Vidigal, Fernanda L Martinho Haddad, Thaís Moura Guimaraes, Luciana Oliveira Silva, Monica L Andersen, Richard Schwab, Peter A Cistulli, Alan I Pack, Sergio Tufik, Lia Rita A Bittencourt
Study Objectives This study aimed to evaluate and compare measurements of standardized craniofacial and intraoral photographs between clinical and general population samples, between groups of individuals with an apnea-hypopnea index (AHI)≥15 and AHI<15, and their interaction, as well as the relationship with the presence and severity of Obstructive sleep apnea (OSA). Methods We used data from 929
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Paradoxical Effects of Daytime Sleepiness and Memory in African Americans at Risk for Alzheimer's Disease. Sleep (IF 5.6) Pub Date : 2023-11-27 Brendan P Lucey
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Associations of Sleep Duration and Daytime Sleepiness with Plasma Amyloid Beta and Cognitive Performance in Cognitively Unimpaired, Middle-Aged and Older Adult African Americans Sleep (IF 5.6) Pub Date : 2023-11-27 Jesse D Cook, Ammara Malik, David T Plante, Derek Norton, Rebecca Langhough Koscik, Lianlian Du, Barabara B Bendlin, Kris M Kirmess, Mary S Holubasch, Matthew R Meyer, Venky Venkatesh, Tim West, Philip B Verghese, Kevin E Yarasheski, Kevin V Thomas, Cynthia M Carlsson, Sanjay Asthana, Sterling C Johnson, Carey E Gleason, Megan Zuelsdorff
Study Objectives Given the established racial disparities in both sleep health and dementia risk for African American populations, we assess cross-sectional and longitudinal associations of self-report sleep duration (SRSD) and daytime sleepiness with plasma amyloid beta (Aβ) and cognition in an African American (AA) cohort. Methods In a cognitively unimpaired sample drawn from the African Americans
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Sleep features and long-term incident neurodegeneration: a polysomnographic study Sleep (IF 5.6) Pub Date : 2023-11-23 Abubaker Ibrahim, Matteo Cesari, Anna Heidbreder, Michaela Defrancesco, Elisabeth Brandauer, Klaus Seppi, Stefan Kiechl, Birgit Högl, Ambra Stefani
Study Objectives Sleep is altered early in neurodegenerative diseases (NDDs) and may contribute to neurodegeneration. Long-term, large sample size studies assessing NDDs association with objective sleep measures are scant. We aimed to investigate whether video-polysomnography (v-PSG)-based sleep features are associated with long-term NDDs incidence. Methods Retrospective cohort study of patients referred
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Associations of gut microbiome richness and diversity with objective and subjective sleep measures in a population sample Sleep (IF 5.6) Pub Date : 2023-11-21 Elizabeth A Holzhausen, Paul E Peppard, Ajay K Sethi, Nasia Safdar, Kristen C Malecki, Amy A Schultz, Courtney L Deblois, Erika W Hagen
Study Objectives Alterations in gut microbiota composition have been associated with several conditions, and there is emerging evidence that sleep quantity and quality are associated with the composition of the gut microbiome. Therefore, this study aimed to assess the associations between several measures of sleep and the gut microbiome in a large, population based sample. Methods Data were collected