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Effect of S-region mutations on HBsAg in HBsAg-negative HBV-infected patients Virol. J. (IF 4.8) Pub Date : 2024-04-23 Hui Liu, Shuxiang Chen, Xin Liu, Jinli Lou
Occult HBV infection (OBI) is a special form of hepatitis B virus (HBV) infection that may cause Liver cirrhosis and hepatocellular carcinoma, causing significant harm to patients. Given the insidious nature of OBI, it is usually not easy to be detected. Most of the samples currently studied are concentrated on blood donors, however, patients in this special state have not been fully studied. This
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A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients Virol. J. (IF 4.8) Pub Date : 2024-04-23 Sepideh Rostami, Seyed Mohammad Alavi, Robab Daghagheleh, Elham Maraghi, Seyed Ahmad Hosseini
This study sought to examine the impact of magnesium supplementation on clinical outcomes and biochemical factors among hospitalized patients with COVID-19. This double-blind, randomized clinical trial was conducted at Razi Hospital, Ahvaz, Iran, between September 2021 and March 2022. Participants aged 18–70 years with moderate disease severity were enrolled. Magnesium supplementation (300 mg daily)
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Nonlinear relationship between viral load and TCT in single/multiple HPV52 infection Virol. J. (IF 4.8) Pub Date : 2024-04-23 Bingbing Ma, Jie Zhou, Weijuan Zhou, Zhanzhong Ma, Juan Chen, Hongbo Hu
To determine the correlation between HPV (human papillomavirus) 52 viral load, multiple infections and ThinPrep cytology test (TCT), to inform clinical management of HPV52-positive women after cervical cancer screening. A total of 1,882 female patients who had positive quantitative HPV tests at Yuebei People's Hospital from January 2020 to December 2022, of whom 533 tested positive for HPV52. We excluded
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MST1/2 exerts a pivotal role in inducing neuroinflammation and Coxsackievirus-A10 replication by interacting with innate immunity Virol. J. (IF 4.8) Pub Date : 2024-04-19 Yajie Hu, Minigmei Zhong, Yaming Lv, Wei Zhao, Baojiang Qian, Jie Song, Yunhui Zhang
Coxsackievirus-A10 (CV-A10), responsible for the hand, foot and mouth disease (HFMD) pandemic, could cause serious central nervous system (CNS) complications. The underlying molecular basis of CV-A10 and host interactions inducing neuropathogenesis is still unclear. The Hippo signaling pathway, historically known for a dominator of organ development and homeostasis, has recently been implicated as
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Computational analysis of affinity dynamics between the variants of SARS-CoV-2 spike protein (RBD) and human ACE-2 receptor Virol. J. (IF 4.8) Pub Date : 2024-04-19 Nishad Sultana, S. N. Nagesha, C. N. Lakshminarayana Reddy, B. N. Ramesh, S. Shyamalamma, K. S. Shashidhara, K. M. Satish, C. Pradeep, G. D Vidyadhar
The novel coronavirus SARS-CoV-2 resulted in a significant worldwide health emergency known as the COVID-19 pandemic. This crisis has been marked by the widespread of various variants, with certain ones causing notable apprehension. In this study, we harnessed computational techniques to scrutinize these Variants of Concern (VOCs), including various Omicron subvariants. Our approach involved the use
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Stability and integrity of self-assembled bovine parvovirus virus‑like particles (BPV‑VLPs) of VP2 and combination of VP1VP2 assisted by baculovirus-insect cell expression: a potential logistical platform for vaccine deployment Virol. J. (IF 4.8) Pub Date : 2024-04-19 Ashenafi Kiros Wubshet, Guo-xiu Li, Qian Li, Jun-Fei Dai, Yao-Zhong Ding, Luoyi Zhou, Min Qu, Yang Wang, Zhongyuan Ma, Gebremeskel Mamu Werid, Birhanu Hadush Abera, Asmelash Tassew Kebede, Yuefeng Sun, Xiangping Yin, Yongsheng Liu, Zhang Jie
Bovine parvovirus (BPV) is an autonomous DNA virus with a smaller molecular size and subtle differences in its structural proteins, unlike other animal parvoviruses. More importantly, this virus has the potential to produce visible to silent economic catastrophes in the livestock business, despite receiving very little attention. Parvoviral virus-like particles (VLPs) as vaccines and as logistical
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Deciphering the virome of Chunkung (Cnidium officinale) showing dwarfism-like symptoms via a high-throughput sequencing analysis Virol. J. (IF 4.8) Pub Date : 2024-04-15 Mesele Tilahun Belete, Se Eun Kim, Workitu Firmosa Gudeta, Davaajargal Igori, Jeong A. Kwon, Su-Heon Lee, Jae Sun Moon
Viruses have notable effects on agroecosystems, wherein they can adversely affect plant health and cause problems (e.g., increased biosecurity risks and economic losses). However, our knowledge of their diversity and interactions with specific host plants in ecosystems remains limited. To enhance our understanding of the roles that viruses play in agroecosystems, comprehensive analyses of the viromes
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Isolation and genetic characteristics of Novel H4N1 Avian Influenza viruses in ChongQing, China Virol. J. (IF 4.8) Pub Date : 2024-04-10 Jinyue He, Jing Deng, Xianxian Wen, Mengyuan Yan, Yang Liu, Yunqiu Zhou, XuBin Du, Han Yang, Xiaobin Peng
Avian influenza viruses (AIVs) constitute significant zoonotic pathogens encompassing a broad spectrum of subtypes. Notably, the H4 subtype of AIVs has a pronounced ability to shift hosts. The escalating prevalence of the H4 subtype heightens the concern for its zoonotic potential, signaling an urgent need for vigilance. During the period from December 2021 to November 2023, we collected AIV-related
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Recombination analysis on the receptor switching event of MERS-CoV and its close relatives: implications for the emergence of MERS-CoV Virol. J. (IF 4.8) Pub Date : 2024-04-10 Jarel Elgin Tolentino, Spyros Lytras, Jumpei Ito, Kei Sato
PlMERS-CoV is a coronavirus known to cause severe disease in humans, taxonomically classified under the subgenus Merbecovirus. Recent findings showed that the close relatives of MERS-CoV infecting vespertillionid bats (family Vespertillionidae), named NeoCoV and PDF-2180, use their hosts’ ACE2 as their entry receptor, unlike the DPP4 receptor usage of MERS-CoV. Previous research suggests that this
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Immunopathological investigation and genetic evolution of Avian leukosis virus Subgroup-J associated with myelocytomatosis in broiler flocks in Egypt Virol. J. (IF 4.8) Pub Date : 2024-04-10 Ahmed Fotouh, Eman Abd El-Menamm Shosha, Ali Mahmood Zanaty, Marwa Mostafa Darwesh
Avian leukosis virus Subgroup-J (ALV-J) is a rapidly oncogenic evolving retrovirus infecting a variety of avian species; causing severe economic losses to the local poultry industry. To investigate ALV-J, a total of 117 blood samples and 57 tissue specimens of different organs were collected for virological, and pathological identification, serological examinations, molecular characterization, and
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Expression of the SARS-CoV-2 receptor-binding domain by live attenuated influenza vaccine virus as a strategy for designing a bivalent vaccine against COVID-19 and influenza Virol. J. (IF 4.8) Pub Date : 2024-04-09 Ekaterina Stepanova, Irina Isakova-Sivak, Daria Mezhenskaya, Sergei Niskanen, Victoria Matyushenko, Ekaterina Bazhenova, Alexandra Rak, Pei Fong Wong, Polina Prokopenko, Tatiana Kotomina, Elena Krutikova, Sergei Legotskiy, Bogdan Neterebskii, Tatiana Ostroukhova, Konstantin Sivak, Yana Orshanskaya, Kirill Yakovlev, Larisa Rudenko
Influenza and SARS-CoV-2 are two major respiratory pathogens that cocirculate in humans and cause serious illness with the potential to exacerbate disease in the event of co-infection. To develop a bivalent vaccine, capable of protecting against both infections, we inserted the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein into hemagglutinin (HA) molecule or into the open reading frame
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Development of monoclonal antibodies against oropouche virus and its applicability to immunohistochemical diagnosis Virol. J. (IF 4.8) Pub Date : 2024-04-08 Ana Paula Andreolla, Alessandra Abel Borges, Seigo Nagashima, Caroline Busatta Vaz de Paula, Lucia de Noronha, Nilson I.T. Zanchin, Juliano Bordignon, Claudia Nunes Duarte dos Santos
Orthobunyavirus oropouche ense virus (OROV), the causative agent of Oropouche fever, is widely dispersed in Brazil and South America, causing sporadic outbreaks. Due to the similarity of initial clinical symptoms caused by OROV with other arboviruses found in overlapping geographical areas, differential diagnosis is challenging. As for most neglected tropical diseases, there is a shortage of reagents
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A macrophage-cell model of HIV latency reveals the unusual importance of the bromodomain axis Virol. J. (IF 4.8) Pub Date : 2024-04-05 Javan K. Kisaka, Daniel Rauch, Malachi Griffith, George B. Kyei
Although macrophages are now recognized as an essential part of the HIV latent reservoir, whether and how viral latency is established and reactivated in these cell types is poorly understood. To understand the fundamental mechanisms of viral latency in macrophages, there is an urgent need to develop latency models amenable to genetic manipulations and screening for appropriate latency-reversing agents
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Hepatitis B relapse after entecavir or tenofovir alafenamide cessation under anti-viral prophylaxis for cancer chemotherapy Virol. J. (IF 4.8) Pub Date : 2024-04-03 Hsin-Wei Fang, Po-Lin Tseng, Tsung-Hui Hu, Jing-Houng Wang, Chao-Hung Hung, Sheng-Nan Lu, Chien-Hung Chen
No study has comparing hepatitis B virus (HBV) relapse rates among patients with both cancer and hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) who completed anti-viral prophylaxis for chemotherapy and then stopped taking entecavir or tenofovir alafenamide (TAF). A total of 227 HBeAg-negative cancer patients without cirrhosis who previously took entecavir (n = 144) or TAF (n = 83)
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Inefficient antiviral response in reconstituted small-airway epithelium from chronic obstructive pulmonary disease patients following human parainfluenza virus type 3 infection Virol. J. (IF 4.8) Pub Date : 2024-04-02 Louise Bondeelle, Maud Salmona, Véronique Houdouin, Elise Diaz, Jacques Dutrieux, Séverine Mercier-Delarue, Samuel Constant, Song Huang, Anne Bergeron, Jérôme LeGoff
Chronic obstructive pulmonary disease (COPD) affects over 250 million individuals globally and stands as the third leading cause of mortality. Respiratory viral infections serve as the primary drivers of acute exacerbations, hastening the decline in lung function and worsening the prognosis. Notably, Human Parainfluenza Virus type 3 (HPIV-3) is responsible for COPD exacerbations with a frequency comparable
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Peg-IFNα combined with hepatitis B vaccination contributes to HBsAg seroconversion and improved immune function Virol. J. (IF 4.8) Pub Date : 2024-03-30 Yisi Liu, Shan Ren, Lina Ma, Xiao Lin, Junfeng Lu, Zhenhuan Cao, Sujun Zheng, Zhongjie Hu, Xiaoxue Xu, Xinyue Chen
The purpose of this study was to investigate immunological variations between a group that received the hepatitis B vaccine and a non-vaccine group. We focused on a cohort that achieved HBsAg seroclearance after Peg-IFNα treatment of CHB. We enrolled twenty-eight individuals who achieved HBsAg seroclearance after Peg-IFNα treatment. They were divided into two groups: a vaccine group (n = 14) and a
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DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection Virol. J. (IF 4.8) Pub Date : 2024-03-29 Mélanie Messmer, Louison Pierson, Charline Pasquier, Nikola Djordjevic, Johana Chicher, Philippe Hammann, Sébastien Pfeffer, Erika Girardi
RNA helicases are emerging as key factors regulating host-virus interactions. The DEAD-box ATP-dependent RNA helicase DDX5, which plays an important role in many aspects of cellular RNA biology, was also found to either promote or inhibit viral replication upon infection with several RNA viruses. Here, our aim is to examine the impact of DDX5 on Sindbis virus (SINV) infection. We analysed the interaction
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SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression Virol. J. (IF 4.8) Pub Date : 2024-03-27 Hosni A. M. Hussein, Ali A. Thabet, Ahmed A. Wardany, Ahmed M. El-Adly, Mohamed Ali, Mohamed E. A. Hassan, Mohamed A. B. Abdeldayem, Abdul-Rahman M. A. Mohamed, Ali Sobhy, Mohamed A. El-Mokhtar, Magdy M. Afifi, Samah M. Fathy, Serageldeen Sultan
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is the cause of coronavirus disease 2019 (COVID-19); a severe respiratory distress that has emerged from the city of Wuhan, Hubei province, China during December 2019. COVID-19 is currently the major global health problem and the disease has now spread to most countries in the world. COVID-19 has profoundly impacted human health
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Efficacy of different doses of corticosteroids in treating severe COVID-19 pneumonia Virol. J. (IF 4.8) Pub Date : 2024-03-26 Ge zhang, Lin Su, Wenwen Wu, Qing Qiao, Shuncui Gao, Yan Zhang, Yanmei Zhang
To investigate the efficacy of different doses of corticosteroids in treating severe coronavirus disease 2019 (COVID-19) pneumonia. Between May 01, 2023, and June 20, 2023, 48 patients with severe COVID-19 pneumonia were treated at the Department of Respiratory and Critical Care Medicine of Jinan Fourth People's Hospital. The observation group (21 patients) received standard care and high-dose corticosteroids
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Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19 Virol. J. (IF 4.8) Pub Date : 2024-03-25 Yan Fang, Dajun Fang
Several observational studies demonstrated that pregnant individuals with COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine whether women with COVID-19 diagnosis had adverse pregnancy outcomes. A two-sample Mendelian randomization (MR) analysis in this study was used to evaluate the casual relationships between COVID-19 infection and obstetric-related diseases based
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Hypermethylation of the glutathione peroxidase 4 gene promoter is associated with the occurrence of immune tolerance phase in chronic hepatitis B Virol. J. (IF 4.8) Pub Date : 2024-03-21 Xing Su, Zhaohui Wang, Jihui Li, Shuai Gao, Yuchen Fan, Kai Wang
Hepatitis B virus (HBV) infection is a public health problem that seriously threatens human health. This study aimed to investigate the clinical significance of glutathione peroxidase 4(GPX4) in the occurrence and development of chronic hepatitis B (CHB). A total of 169 participants including 137 patients with CHB and 32 healthy controls (HCs) were recruited. We detected the expression of GPX4 and
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Epidemiology, clinical features and outcomes of hospitalized patients with COVID-19 by vaccination status: a multicenter historical cohort study Virol. J. (IF 4.8) Pub Date : 2024-03-21 Shatha Alshanqeeti, Susan Szpunar, Premchand Anne, Louis Saravolatz, Ashish Bhargava
COVID-19 disease resulted in over six million deaths worldwide. Although vaccines against SARS-CoV-2 demonstrated efficacy, breakthrough infections became increasingly common. There is still a lack of data regarding the severity and outcomes of COVID-19 among vaccinated compared to unvaccinated individuals. This was a historical cohort study of adult COVID-19 patients hospitalized in five Ascension
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Cross-neutralizing antibody against emerging Omicron subvariants of SARS-CoV-2 in infection-naïve individuals with homologous BNT162b2 or BNT162b2(WT + BA.4/5) bivalent booster vaccination Virol. J. (IF 4.8) Pub Date : 2024-03-21 Samuel M.S. Cheng, Chris K.P. Mok, John K.C. Li, Ken K.P. Chan, Kristine S. Luk, Ben H.W. Lee, Haogao Gu, Karl C.K. Chan, Leo C.H. Tsang, Karen Y.S. Yiu, Ken K.C. Ling, Yun Sang Tang, Leo L.H. Luk, Jennifer K.M. Yu, Andrew Pekosz, Richard J. Webby, Benjamin J. Cowling, David S.C. Hui, Malik Peiris
Since the emergence of SARS-CoV-2, different variants and subvariants successively emerged to dominate global virus circulation as a result of immune evasion, replication fitness or both. COVID-19 vaccines continue to be updated in response to the emergence of antigenically divergent viruses, the first being the bivalent RNA vaccines that encodes for both the Wuhan-like and Omicron BA.5 subvariant
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Correction: Seasonality of respiratory syncytial virus infection in children hospitalized with acute lower respiratory tract infections in Hunan, China, 2013–2022 Virol. J. (IF 4.8) Pub Date : 2024-03-20 Le-Yun Xie, Tao Wang, Tian Yu, Xian Hu, Le Yang, Li-Li Zhong, Bing Zhang, Sai-Zhen Zeng
Correction: Virology Journal (2024) 21:62 https://doi.org/10.1186/s12985-024-02336-8 Following publication of the original article [1], we have been notified that Fig. 5 was a duplicate of Fig. 6. Figure 5 has now been replaced with the correct version. The original article has been corrected. Engel et al Trials (2024) 25:81 https://doi.org/10.1186/s12985-024-02336-8 Download referencesAuthor notes
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Early administration of nirmatrelvir/ritonavir leads to faster negative SARS-CoV-2 nasal swabs than monoclonal antibodies in COVID 19 patients at high-risk for severe disease Virol. J. (IF 4.8) Pub Date : 2024-03-20 Marta Colaneri, Giovanni Scaglione, Federico Fassio, Lucia Galli, Alessia Lai, Annalisa Bergna, Arianna Gabrieli, Maciej Tarkowski, Carla Della Ventura, Valeria Colombo, Laura Cordier, Davide Bernasconi, Mario Corbellino, Gianfranco Dedivitiis, Silvia Borghetti, Debora Visigalli, Salvatore Sollima, Giacomo Casalini, Giuliano Rizzardini, Andrea Gori, Spinello Antinori, Agostino Riva, Monica Schiavini
Besides the well-established efficacy in preventing severe COVID-19, the impact of early treatments, namely antivirals and monoclonal antibodies (mAbs), on the time length to negativization of SARS-CoV-2 nasal swabs is still unclear. The aim of this study was to compare the efficacy of different early treatments in reducing the SARS-CoV-2 viral shedding, identifying a single drug that might potentially
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A computational approach to design a multiepitope vaccine against H5N1 virus Virol. J. (IF 4.8) Pub Date : 2024-03-20 Fatemeh Dashti, Arash Raisi, Ghazaleh Pourali, Zahra Sadat Razavi, Fatemeh Ravaei, Javid Sadri Nahand, Fatemeh Kourkinejad-Gharaei, Seyed Mohammad Ali Mirazimi, Javad Zamani, Hossein Tarrahimofrad, Seyed Mohammad Reza Hashemian, Hamed Mirzaei
Since 1997, highly pathogenic avian influenza viruses, such as H5N1, have been recognized as a possible pandemic hazard to men and the poultry business. The rapid rate of mutation of H5N1 viruses makes the whole process of designing vaccines extremely challenging. Here, we used an in silico approach to design a multi-epitope vaccine against H5N1 influenza A virus using hemagglutinin (HA) and neuraminidase
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Correction: antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023 Virol. J. (IF 4.8) Pub Date : 2024-03-18 Even Fossum, Andreas Rohringer, Torstein Aune, Kjersti Margrethe Rydland, Karoline Bragstad, Olav Hungnes
Correction: Fossum et al. Virology Journal (2024) 21:57 https://doi.org/10.1186/s12985-024-02326-w. Following the publication of the original article [1], the author reported that the figures had been mistakenly reordered during publication: Fig. 1 was presented as Fig. 4 Fig. 2 was presented as Fig. 5 Fig. 3 was presented as Fig. 1 Fig. 4 was presented as Fig. 2; and Fig. 5 was presented as Fig. 3
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Liver injury in COVID-19: an insight into pathobiology and roles of risk factors Virol. J. (IF 4.8) Pub Date : 2024-03-15 Abbas Tazarghi, Sahar Bazoq, Mohammad Hosein Taziki Balajelini, Mohsen Ebrahimi, Seyed Mehran Hosseini, Hadi Razavi Nikoo
COVID-19 is a complex disease that can lead to fatal respiratory failure with extrapulmonary complications, either as a direct result of viral invasion in multiple organs or secondary to oxygen supply shortage. Liver is susceptible to many viral pathogens, and due to its versatile functions in the body, it is of great interest to determine how hepatocytes may interact with SARS-CoV-2 in COVID-19 patients
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Development of a time-resolved fluorescence immunoassay kit for detecting canine coronavirus and parvovirus through double labeling Virol. J. (IF 4.8) Pub Date : 2024-03-11 Laiqing Li, Cuicui Chen, Huankun Liang, Wenqi Dong, V. N. Leontiev, Igor Vitalievich Voytov
Canine enteric coronavirus (CCV) and canine parvovirus type 2 (CPV-2) are the main pathogens responsible for acute gastroenteritis in dogs, and both single and mixed infections are common. This study aimed to establish a double-labeling time-resolved fluorescence immunoassay (TRFIA) to test and distinguish CCV and CPV-2 diseases. A sandwich double-labeling TRFIA method was established and optimized
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Congenital CMV infection in a Brazilian neonatal intensive care unit: high prevalence among twin newborns Virol. J. (IF 4.8) Pub Date : 2024-03-08 Lauro Juliano Marin, Pérola Rodrigues dos Santos, Felipe Charu Ramos, Uener Ribeiro dos Santos, Marcílio Marques, Luciana Debortoli de Carvalho, Sandra Rocha Gadelha, Victor Hugo Aquino
Cytomegalovirus (CMV) is one of the most important pathogens associated with congenital infection worldwide. Most congenital CMV-infected infants are asymptomatic at birth; however, some can develop delayed sequelae, especially hearing loss. This study aimed to investigate the prevalence of congenital CMV infection in a neonatal intensive care unit in a low-income region of Brazil. The objectives extended
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Seasonality of respiratory syncytial virus infection in children hospitalized with acute lower respiratory tract infections in Hunan, China, 2013–2022 Virol. J. (IF 4.8) Pub Date : 2024-03-07 Le-Yun Xie, Tao Wang, Tian Yu, Xian Hu, Le Yang, Li-Li Zhong, Bing Zhang, Sai-Zhen Zeng
In China, respiratory syncytial virus (RSV) infections traditionally occur during the spring and winter seasons. However, a shift in the seasonal trend was noted in 2020–2022, during the coronavirus disease 2019 (COVID-19) pandemic. This study investigated the seasonal characteristics of RSV infection in children hospitalized with acute lower respiratory tract infections (ALRTIs). The RSV epidemic
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SARS-CoV-2 infection increases airway bleeding risk in patients after tracheostomies Virol. J. (IF 4.8) Pub Date : 2024-03-07 Shupin Tang, Gongbiao Lin, Xiaobo Wu, Zhihong Chen
Airway bleeding events are a rare incident in SARS-CoV-2-infected patients after tracheostomies. We aimed to explore the correlation between airway bleeding and SARS-CoV-2 infection and evaluate the consistency of SARS-CoV-2 RNA test results in the upper and lower airway samples from patients after tracheostomies. Forty-four patients after temporary or permanent tracheostomy were divided into a positive
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RNA-seq analysis of chlorogenic acid intervention in duck embryo fibroblasts infected with duck plague virus Virol. J. (IF 4.8) Pub Date : 2024-03-07 Yunyun Yang, Qiandong Zhang, Haiqing Cai, Yi Feng, Anlin Wen, Ying Yang, Ming Wen
Chlorogenic acid, the primary active component in Chinese medicines like honeysuckle, exhibits anti-inflammatory and antiviral effects. It has been demonstrated that chlorogenic acid effectively prevents and treats Duck enteritis virus (DEV) infection. This study aims to further elucidate the mechanism by which chlorogenic acid prevents DEV infection. Duck embryo fibroblast (DEF) cells were pre-treated
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Epidemiology and diagnosis technologies of human metapneumovirus in China: a mini review Virol. J. (IF 4.8) Pub Date : 2024-03-07 Yuan Feng, Tao He, Bo Zhang, Haibin Yuan, Yinfei Zhou
Human metapneumovirus (HMPV) is a newly identified pathogen causing acute respiratory tract infections in young infants worldwide. Since the initial document of HMPV infection in China in 2003, Chinese scientists have made lots of efforts to prevent and control this disease, including developing diagnosis methods, vaccines and antiviral agents against HMPV, as well as conducting epidemiological investigations
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Aspergillus fumigatus secretes a protease(s) that displays in silico binding affinity towards the SARS-CoV-2 spike protein and mediates SARS-CoV-2 pseudovirion entry into HEK-293T cells Virol. J. (IF 4.8) Pub Date : 2024-03-06 Nozethu Mjokane, Eric O. Akintemi, Saheed Sabiu, Onele M. N. Gcilitshana, Jacobus Albertyn, Carolina H. Pohl, Olihile M. Sebolai
The novel coronavirus disease of 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Data from the COVID-19 clinical control case studies showed that this disease could also manifest in patients with underlying microbial infections such as aspergillosis. The current study aimed to determine if the Aspergillus (A.) fumigatus culture media
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Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023 Virol. J. (IF 4.8) Pub Date : 2024-03-06 Even Fossum, Andreas Rohringer, Torstein Aune, Kjersti Margrethe Rydland, Karoline Bragstad, Olav Hungnes
Non-pharmaceutical interventions implemented during the COVID-19 pandemic resulted in a marked reduction in influenza infections globally. The absence of influenza has raised concerns of waning immunity, and potentially more severe influenza seasons after the pandemic. To evaluate immunity towards influenza post-COVID-19 pandemic we have assessed influenza A epidemics in Norway from October 2016 to
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Bacterial isolation and genome analysis of a novel Klebsiella quasipneumoniae phage in southwest China’s karst area Virol. J. (IF 4.8) Pub Date : 2024-03-06 Yanju Liu, Jinfeng Wang, Ruoyu Zhao, Xiaoping Liu, Yang Dong, Wenyu Shi, Hongchen Jiang, Xiangyu Guan
Southwest China is one of the largest karst regions in the world. Karst environment is relatively fragile and vulnerable to human activities. Due to the discharge of sewage and domestic garbage, the karst system may be polluted by pathogenic bacteria. The detection of bacterial distribution and identification of phage capable of infecting them is an important approach for environmental assessment and
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Unraveling the genetic variations underlying virulence disparities among SARS-CoV-2 strains across global regions: insights from Pakistan Virol. J. (IF 4.8) Pub Date : 2024-03-06 Momina Jabeen, Shifa Shoukat, Huma Shireen, Yiming Bao, Abbas Khan, Amir Ali Abbasi
Over the course of the COVID-19 pandemic, several SARS-CoV-2 variants have emerged that may exhibit different etiological effects such as enhanced transmissibility and infectivity. However, genetic variations that reduce virulence and deteriorate viral fitness have not yet been thoroughly investigated. The present study sought to evaluate the effects of viral genetic makeup on COVID-19 epidemiology
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The POU-HD TFs impede the replication efficiency of several human papillomavirus genomes Virol. J. (IF 4.8) Pub Date : 2024-03-05 Martin Kala, Sofiya Babok, Nika Mikhailava, Marko Piirsoo, Alla Piirsoo
Human papillomavirus (HPV) is a double-stranded DNA virus that infects cutaneous and mucosal epithelial cells. HPV replication initiates at the origin (ori), located within a noncoding region near the major early promoter. Only two viral proteins, E1 and E2, are essential for replication, with the host cell contributing other necessary factors. However, the role of host cell proteins in regulating
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Development and application of an indirect ELISA for detection of antibodies against emerging atypical porcine pestivirus Virol. J. (IF 4.8) Pub Date : 2024-03-04 Hao Song, Xiaowei Gao, Jing Li, Xinying Dong, Yanhui Fu, Lina Shao, Jiaoer Zhang, Hua-Ji Qiu, Yuzi Luo
Atypical porcine pestivirus (APPV) is a newly discovered swine pestivirus, which can cause congenital tremor and high mortality in newborn piglets and subclinical infection in adult pigs, leading to significant impacts on the pig industry. Currently, there is no approved serological method to assess APPV infection status in pig farms. In this study, the envelope glycoprotein E2 of APPV was highly expressed
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Prevalence and genotype distribution of HPV infections among women in Chengdu,China Virol. J. (IF 4.8) Pub Date : 2024-03-01 Junying Zhang, Tianzhi Zha, Xuemei Wang, Weijun He
Human papilloma virus (HPV) infection among female is the cause of cervical cancer and genital warts. In China, the HPV vaccination rate and the target population screening rate among females are low, and the aims of this study on the genotype distribution and prevalence of HPV infection were to provide more targeted strategies for the prevention and treatment of cervical cancer and HPV-related diseases
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Diversity of astroviruses in wild animals in Yunnan province, China Virol. J. (IF 4.8) Pub Date : 2024-02-27 Xingyu Huang, Junjie Hou, Xiang Le, Yutong Hou, Lingsi Yang, Qian Li, Binghui Wang, Xueshan Xia
Astroviruses (AstVs) are single-stranded RNA viruses that have been detected in a wide range of mammals and birds. They are associated with numerous interspecies transmissions and viral recombination events, posing a threat to human and animal health. We collected 1,333 samples from wild animals, including bats, rodents, wild boars, and birds, from various states and cities in the Yunnan Province,
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Molecular epidemiology and phylogenetic analysis of feline calicivirus in Kunshan, China Virol. J. (IF 4.8) Pub Date : 2024-02-27 Semin Kim, Yixi Cheng, Zhenkun Fang, Xinyue Liu, Qiu Zhongqi, Yu Weidong, Aysun Yilmaz, Huseyin Yilmaz, Sajid Umar
Feline calicivirus (FCV) is a highly contagious virus in cats, which typically causes respiratory tract and oral infections. Despite vaccination against FCV being a regular practice in China, new FCV cases still occur. Antigenic diversity of FCV hinders the effective control by vaccination. This is first report which aims to investigate the molecular epidemiology and molecular characteristics of FCV
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Identification and characterisation of Gamma-herpesviruses in zoo artiodactyla Virol. J. (IF 4.8) Pub Date : 2024-02-23 Laura Bianchessi, Edmund Flach, Giulia Monacchia, Mark Dagleish, Madeleine Maley, Lauretta Turin, Mara Silvia Rocchi
Viruses within the γ-herpesviruses subfamily include the causative agents of Malignant Catarrhal Fever (MCF) in several species of the order Artiodactyla. MCF is a usually fatal lymphoproliferative disease affecting non-adapted host species. In adapted host species these viruses become latent and recrudesce and transmit during times of stress or immunosuppression. The undetected presence of MCF-causing
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Green synthesis of MnO2 NPs using Arabic gum: assessing its potential antiviral activity against influenza A/H1N1 Virol. J. (IF 4.8) Pub Date : 2024-02-23 Neda Baghban, Safieh Momeni, Emad Behboudi, Hassan Dianat-Moghadam, Amirhossein Darabi, Hadiseh Shokouhi Targhi, Mohsen Keshavarz
The antiviral properties of metal nanoparticles against various viruses, including those resistant to drugs, are currently a subject of intensive research. Recently, the green synthesis of nanoparticles and their anti-viral function have attracted a lot of attention. Previous studies have shown promising results in the use of Arabic gum for the green synthesis of nanoparticles with strong antiviral
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A pilot investigation of the association between HIV-1 Vpr amino acid sequence diversity and the tryptophan-kynurenine pathway as a potential mechanism for neurocognitive impairment Virol. J. (IF 4.8) Pub Date : 2024-02-23 Levanco Keegan Asia, Esmé Jansen Van Vuren, Zander Lindeque, Monray Edward Williams
HIV infection compromises both the peripheral and central immune systems due to its pathogenic and neuropathogenic features. The mechanisms driving HIV-1 pathogenesis and neuropathogenesis involve a series of events, including metabolic dysregulation. Furthermore, HIV-subtype-specific variations, particularly alterations in the amino acid sequences of key viral proteins, are known to influence the
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Effectiveness of azvudine in reducing mortality of COVID-19 patients: a systematic review and meta-analysis Virol. J. (IF 4.8) Pub Date : 2024-02-23 Yaqi Wang, Huaiya Xie, Luo Wang, Junping Fan, Ying Zhang, Siqi Pan, Wangji Zhou, Qiaoling Chen, Xueqi Liu, Aohua Wu, Hong Zhang, Jinglan Wang, Xinlun Tian
Azvudine has been approved for the treatment of coronavirus disease 2019 (COVID-19) patients in China, and this meta-analysis aims to illustrate the safety of azvudine and its effectiveness in reducing mortality. PubMed, Embase, Web of science, Cochrane Library and the Epistemonikos COVID-19 Living Overview of Evidence database (L.OVE) were searched to aggregate currently published studies. Cochrane
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Cytomegalovirus infection during pregnancy: cross-sectional survey of knowledge and prevention practices of healthcare professionals in French-speaking Switzerland Virol. J. (IF 4.8) Pub Date : 2024-02-21 Pauline Sartori, David Baud, Begoña Martinez de Tejada, Alexandre Farin, Marie-Claude Rossier, Wawrzyniec Rieder, Sylvie Rouiller, Romaine Robyr, Gaston Grant, Béatrice Eggel, Adrien Bruno, Maeva Pretalli, Bertrand Gainon, Romina Capoccia-Brugger, Laetitia Ammon-Chansel, Clarisse De Courten, Nathalie Beurret-Lepori, Jonathan Baert, Yvan Vial, Léo Pomar
Lack of Cytomegalovirus (CMV) knowledge among healthcare professionals has been proven to be the main threat to pregnant women's awareness, preventing them from reducing the risk of infection. The aims of this study were to assess the knowledge and practices of French-speaking Swiss perinatal professionals in terms of CMV prevention, as well as the sociodemographic-professional factors that influence
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Phage vB_Ec_ZCEC14 to treat antibiotic-resistant Escherichia coli isolated from urinary tract infections Virol. J. (IF 4.8) Pub Date : 2024-02-16 Nedaa M. Ismael, Mohamed Azzam, Mohamed Abdelmoteleb, Ayman El-Shibiny
Escherichia coli is a commensal bacterial species in the human gastrointestinal tract; however, it could be pathogenic and cause severe infections in intra and extra-intestinal sites. Uropathogenic E. coli accounts for 80–90% of urinary tract infections that can result in urosepsis and septic shock. Consequently, multidrug-resistant uropathogenic E. coli poses a considerable risk to the healthcare
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Correction: Role of human heterogeneous nuclear ribonucleoprotein C1/C2 in dengue virus replication Virol. J. (IF 4.8) Pub Date : 2024-02-15 Thanyaporn Dechtawewat, Pucharee Songprakhon, Thawornchai Limjindaporn, Chunya Puttikhunt, Watchara Kasinrerk, Sawanan Saitornuang, Pa-thai Yenchitsomanus, Sansanee Noisakran
Correction: Virology Journal (2015) 12:14 https://doi.org/10.1186/s12985-014-0219-7 Following publication of the original article [1], the authors informed us that the citation number 5., “Recent advances in DENV receptors, The Scientific World Journal, Volume 2013,” was excluded from the original article due to its retraction in 2013. Dechtawewat et al. Virology Journal (2015) 12:14. https://doi.org/10
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Detecting the impacts of humidity, rainfall, temperature, and season on chikungunya, dengue and Zika viruses in Aedes albopictus mosquitoes from selected sites in Cebu city, Philippines Virol. J. (IF 4.8) Pub Date : 2024-02-15 Frances Edillo, Rhoniel Ryan Ymbong, Anthoddiemn Olin Navarro, Maureen Mathilde Cabahug, Kristilynn Saavedra
Aedes albopictus is the secondary vector for dengue virus (DENV) in the Philippines, and also harbors chikungunya (CHIKV) and Zika (ZIKV) viruses. This study aimed to determine the minimum infection rates (MIRs) of CHIKV, DENV serotypes, and ZIKV in Ae. albopictus collected from selected two-site categories by altitude (highland [H] and lowland [L] sites) in Cebu city, Philippines during the wet (WS)
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Recognizing the role of Epstein-Barr virus in gastric cancer: transcriptomic insights into malignancy modulation Virol. J. (IF 4.8) Pub Date : 2024-02-14 Tabassom Sedaghat Anbouhi, Hossein Sazegar, Ebrahim Rahimi
Studies show that Epstein-Barr virus (EBV) infection can play a role in malignancy and increase the risk of gastric cancer (GC). The objective of this research was to pinpoint genes whose expression may be influenced by EBV and play a role in the development of GC. Candidate genes potentially susceptible to expression modulation in the presence of EBV were identified through the analysis of GSE185627
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Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic: role of the Belgian National Reference Centre Virol. J. (IF 4.8) Pub Date : 2024-02-10 Reile Janssen, Lize Cuypers, Lies Laenen, Els Keyaerts, Kurt Beuselinck, Sunita Janssenswillen, Bram Slechten, Jannes Bode, Elke Wollants, Kristel Van Laethem, Annabel Rector, Mandy Bloemen, Anke Sijmons, Nathalie de Schaetzen, Arnaud Capron, Kurt Van Baelen, Thierry Pascal, Céline Vermeiren, Fabrice Bureau, Jo Vandesompele, Pieter De Smet, Wouter Uten, Hugues Malonne, Pierre Kerkhofs, Jo De Cock,
Since the onset of the coronavirus disease (COVID-19) pandemic in Belgium, UZ/KU Leuven has played a crucial role as the National Reference Centre (NRC) for respiratory pathogens, to be the first Belgian laboratory to develop and implement laboratory developed diagnostic assays for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) and later to assess the quality of commercial kits. To meet
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Prevalence and progression of pneumonia in immunocompetent adults with varicella Virol. J. (IF 4.8) Pub Date : 2024-02-09 Ran Cheng, Fei Lin, Zhonghua Deng, Jingjin Liang, Xiaoguang Li, Ming Lu, Lu Li
Pneumonia is the most common complication of varicella infections. Although previous studies have tended to focus mainly on immunocompromised patients, varicella pneumonia can also occur in healthy adults. Therefore, in this study, we aimed to assess the progression of varicella pneumonia in immunocompetent hosts. This retrospective study involved immunocompetent adult outpatients with varicella who
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Mechanisms and consequences of mRNA destabilization during viral infections Virol. J. (IF 4.8) Pub Date : 2024-02-06 Soraya I. Shehata, J. Monty Watkins, James M. Burke, Roy Parker
During viral infection there is dynamic interplay between the virus and the host to regulate gene expression. In many cases, the host induces the expression of antiviral genes to combat infection, while the virus uses “host shut-off” systems to better compete for cellular resources and to limit the induction of the host antiviral response. Viral mechanisms for host shut-off involve targeting translation
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Novel neutralizing SARS-CoV-2-specific mAbs offer detection of RBD linear epitopes Virol. J. (IF 4.8) Pub Date : 2024-02-06 Seyed Mostafa Mostafavi Zadeh, Ali Ahmad Bayat, Hosein Shahsavarani, Feridoun Karimi-Busheri, Jafar Kiani, Roya Ghods, Zahra Madjd
To stop the spread of the COVID-19 disease, it is crucial to create molecular tools to investigate and diagnose COVID-19. Current efforts focus on developing specific neutralizing monoclonal antibodies (NmAbs) elicited against the receptor-binding domain (RBD). In the present study, recombinant RBD (rRBD) protein was produced in E. coli, followed by immunizing mice with purified rRBD. ELISA was applied
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Development of a highly sensitive and specific intact proviral DNA assay for HIV-1 subtype B and C Virol. J. (IF 4.8) Pub Date : 2024-01-31 N. V. E. J. Buchholtz, M. M. Nühn, T. C. M. de Jong, T. A. T. Stienstra, K. Reddy, T. Ndung’u, Z. M. Ndhlovu, K. Fisher, S. Palmer, A. M. J. Wensing, J. Symons, M. Nijhuis
HIV reservoir quantification is essential for evaluation of HIV curative strategies and may provide valuable insights about reservoir dynamics during antiretroviral therapy. The Intact Proviral DNA Assay (IPDA) provides the unique opportunity to quantify the intact and defective reservoir. The current IPDA is optimized for HIV-1 subtype B, the dominant subtype in resource-rich settings. However, subtype
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ZNF148 inhibits HBV replication by downregulating RXRα transcription Virol. J. (IF 4.8) Pub Date : 2024-01-31 Xinyan Yao, Kexin Xu, Nana Tao, Shengtao Cheng, Huajian Chen, Dapeng Zhang, Minli Yang, Ming Tan, Haibo Yu, Peng Chen, Zongzhu Zhan, Siyi He, Ranran Li, Chunduo Wang, Daiqing Wu, Jihua Ren
Progressive hepatitis B virus (HBV) infection can result in cirrhosis, hepatocellular cancer, and chronic hepatitis. While antiviral drugs that are now on the market are efficient in controlling HBV infection, finding a functional cure is still quite difficult. Identifying host factors involved in regulating the HBV life cycle will contribute to the development of new antiviral strategies. Zinc finger
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A state-of-the-art review of the recent advances in exosome isolation and detection methods in viral infection Virol. J. (IF 4.8) Pub Date : 2024-01-30 Amirsasan Gorgzadeh, Ahmad Nazari, Adnan Ali Ehsan Ismaeel, Diba Safarzadeh, Jawad A. K. Hassan, Saman Mohammadzadehsaliani, Hadis Kheradjoo, Pooneh Yasamineh, Saman Yasamineh
Proteins, RNA, DNA, lipids, and carbohydrates are only some of the molecular components found in exosomes released by tumor cells. They play an essential role in healthy and diseased cells as messengers of short- and long-distance intercellular communication. However, since exosomes are released by every kind of cell and may be found in blood and other bodily fluids, they may one day serve as biomarkers
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Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3 Virol. J. (IF 4.8) Pub Date : 2024-01-29 Zhilei Zhao, Shuyi Han, Qingxun Zhang, Ye Wang, Kening Yue, Salbia Abbas, Hongxuan He
Influenza A virus (IAV) can cause severe and life-threatening illness in humans and animals. Therefore, it is important to search for host antiviral proteins and elucidate their antiviral mechanisms for the development of potential treatments. As a part of human innate immunity, host restriction factors can inhibit the replication of viruses, among which SAM and HD domain containing deoxynucleoside