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The human microbiota is a beneficial reservoir for SARS-CoV-2 mutations mBio (IF 6.4) Pub Date : 2024-03-26 Birong Cao, Xiaoxi Wang, Wanchao Yin, Zhaobing Gao, Bingqing Xia
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations are rapidly emerging, in particular advantageous mutations in the spike (S) protein, which either increase transmissibility or lead to immune escape and are posing a major challenge to ...
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IFN-λ drives distinct lung immune landscape changes and antiviral responses in human metapneumovirus infection mBio (IF 6.4) Pub Date : 2024-03-26 Jorna SojatiOlivia B. ParksYu ZhangSara WaltersJie LanTaylor EddensDequan LouLi FanKong ChenTim D. OuryJohn V. Williams1Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA2Department of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA3Department of Pathology, University of Pittsburgh
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Expression of the MSPDBL2 antigen in a discrete subset of Plasmodium falciparum schizonts is regulated by GDV1 but may not be linked to sexual commitment mBio (IF 6.4) Pub Date : 2024-03-26 Aline Freville, Lindsay B. Stewart, Kevin K. A. Tetteh, Moritz Treeck, Alfred Cortes, Till S. Voss, Sarah J. Tarr, David A. Baker, David J. Conway
Malaria parasites in the blood are remarkably variable, able to switch antigenic targets so they may survive within humans who have already developed specific immune responses. This is one of the challenges in developing vaccines against malaria. MSPDBL2 ...
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Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus mBio (IF 6.4) Pub Date : 2024-03-26 Li-Yin LaiNidhi SatishkumarSasha CardozoVijay HemmadiLeonor B. MarquesLiusheng HuangSergio R. FilipeMariana G. PinhoHenry F. ChambersSom S. Chatterjee1Department of Microbial Pathogenesis, School of Dentistry, University of Maryland Baltimore, Baltimore, Maryland, USA2Institute of Marine and Environmental Technology (IMET), Baltimore, Maryland, USA3Instituto de Tecnologia Química e Biológica António
mBio, Ahead of Print.
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HIV-1 capsid stability and reverse transcription are finely balanced to minimize sensing of reverse transcription products via the cGAS-STING pathway mBio (IF 6.4) Pub Date : 2024-03-26 Jenna E. Eschbach, Maritza Puray-Chavez, Shawn Mohammed, Qiankun Wang, Ming Xia, Lin-Chen Huang, Liang Shan, Sebla B. Kutluay
In HIV-1 particles, the dimeric RNA genome and associated viral proteins and enzymes are encased in a proteinaceous lattice composed of the viral capsid protein. Herein, we assessed how altering the stability of this capsid lattice through orthogonal ...
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Priorities, opportunities, and challenges for integrating microorganisms into Earth system models for climate change prediction mBio (IF 6.4) Pub Date : 2024-03-25 J. T. Lennon, R. Z. Abramoff, S. D. Allison, R. M. Burckhardt, K. M. DeAngelis, J. P. Dunne, S. D. Frey, P. Friedlingstein, C. V. Hawkes, B. A. Hungate, S. Khurana, S. N. Kivlin, N. M. Levine, S. Manzoni, A. C. Martiny, J. B. H. Martiny, N. K. Nguyen, M. Rawat, D. Talmy, K. Todd-Brown, M. Vogt, W. R. Wieder, E. J. Zakem
For more than a century, scientists have been developing models to understand and predict the complexity of Earth system dynamics (1). Earth system models (ESMs) are built from a collection of submodels that represent interactions among processes occurring on land, in the oceans, and in the atmosphere. ESMs are intended to capture emergent properties and feedbacks that operate at large scales, ranging
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Retraction for Li et al., “The current state of research on influenza antiviral drug development: drugs in clinical trial and licensed drugs” mBio (IF 6.4) Pub Date : 2024-03-22 Yanbai LiShanshan HuoZhe YinZuguang TianFang HuangPeng LiuYue LiuFei Yu
mBio, Ahead of Print.
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Erratum for Karaba et al., “Endemic Human Coronavirus Antibody Levels Are Unchanged after Convalescent or Control Plasma Transfusion for Early Outpatient COVID-19 Treatment” mBio (IF 6.4) Pub Date : 2024-03-21 Andrew H. KarabaTrevor S. JohnstonEvan BeckOliver LaeyendeckerAndrea L. CoxSabra L. KleinDavid J. Sullivan
mBio, Ahead of Print.
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Cryptococcus neoformans rapidly invades the murine brain by sequential breaching of airway and endothelial tissues barriers, followed by engulfment by microglia mBio (IF 6.4) Pub Date : 2024-03-21 Vanessa I. Francis, Corin Liddle, Emma Camacho, Madhura Kulkarni, Samuel R. S. Junior, Jamie A. Harvey, Elizabeth R. Ballou, Darren D. Thomson, Gordon D. Brown, J. Marie Hardwick, Arturo Casadevall, Jonathan Witton, Carolina Coelho
Cryptococcal meningitis causes 10%–15% of AIDS-associated deaths globally. Still, brain-specific immunity to cryptococci is a conundrum. By employing innovative imaging, this study reveals what occurs during the first days of infection in brain and in ...
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Host-derived protease promotes aggregation of Staphylococcus aureus by cleaving the surface protein SasG mBio (IF 6.4) Pub Date : 2024-03-21 Heidi A. CrosbyKlara KeimJakub M. KwiecinskiChristophe J. Langouët-AstriéKaori OshimaWells B. LaRivièreEric P. SchmidtAlexander R. Horswill1Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA2Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland3Division of Pulmonary Sciences
mBio, Ahead of Print.
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Genome-wide profiling of Hfq-bound RNAs reveals the iron-responsive small RNA RusT in Caulobacter crescentus mBio (IF 6.4) Pub Date : 2024-03-21 Laura N. VogtGaël PanisAnna SchäpersNikolai PeschekMichaela HuberKai PapenfortPatrick H. ViollierKathrin S. Fröhlich1Institute of Microbiology, Faculty of Biological Sciences, Friedrich Schiller University, Jena, Germany2Department of Biology I, Microbiology, Ludwig-Maximilians-University Munich, Munich, Germany3Department of Microbiology and Molecular Medicine, Faculty of Medicine/Centre Médical Universitaire
mBio, Ahead of Print.
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Proteins à la carte: riboproteogenomic exploration of bacterial N-terminal proteoform expression mBio (IF 6.4) Pub Date : 2024-03-21 Igor Fijalkowski, Valdes Snauwaert, Petra Van Damme
With the emerging theme of genes within genes comprising the existence of alternative open reading frames (ORFs) generated by translation initiation at in-frame start codons, mechanisms that control the relative utilization of annotated and alternative ...
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LVS ΔcapB-vectored multiantigenic melioidosis vaccines protect against lethal respiratory Burkholderia pseudomallei challenge in highly sensitive BALB/c mice mBio (IF 6.4) Pub Date : 2024-03-21 Michael V. Tullius, Richard A. Bowen, Peter S. Back, Saša Masleša-Galić, Susana Nava, Marcus A. Horwitz
Melioidosis, a major neglected disease caused by the intracellular bacterial pathogen Burkholderia pseudomallei, is endemic in many tropical areas of the world and causes an estimated 165,000 cases and 89,000 deaths in humans annually. Moreover, B. ...
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Structural insight into Escherichia coli CsgA amyloid fibril assembly mBio (IF 6.4) Pub Date : 2024-03-19 Fan BuDerek R. DeeBin Liu1The Hormel Institute, University of Minnesota, Austin, Minnesota, USA2Faculty of Land and Food Systems, The University of British Columbia, Vancouver, British Columbia, Canada3Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA, Matthew R. Chapman
mBio, Ahead of Print.
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Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection mBio (IF 6.4) Pub Date : 2024-03-19 Jacob DocktermanJeffrey R. ReitanoJeffrey I. EverittGraham D. WallaceMeghan HendrixGregory A. TaylorJörn Coers1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA2Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA3Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA4Geriatric
mBio, Ahead of Print.
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Ehrlichia effector TRP120 manipulates bacteremia to facilitate tick acquisition mBio (IF 6.4) Pub Date : 2024-03-19 Tsian ZhangRory C. ChienKhemraj BudachetriMingqun LinProsper BoyakaWeiyan HuangYasuko Rikihisa1Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA, Jose A. Vazquez-Boland
mBio, Ahead of Print.
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Structural insights into the Clp protein degradation machinery mBio (IF 6.4) Pub Date : 2024-03-19 Xiaolong XuYanhui WangWei HuangDanyang LiZixin DengFeng Long1Department of Neurosurgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China2Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China3Cryo-EM Center and the Core Facility of Wuhan University
mBio, Ahead of Print.
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The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions mBio (IF 6.4) Pub Date : 2024-03-19 Sarah CharitalSerena ShunmugamSheena DassAnna Maria AlazziChristophe-Sébastien ArnoldNicholas J. KatrisSamuel DuleyNyamekye A. QuansahFabien PierrelJérôme GovinYoshiki Yamaryo-BottéCyrille Y. Botté1Apicolipid Team, Institute for Advanced Biosciences, CNRS UMR5309, INSERM U1209, Université Grenoble Alpes, Grenoble, France2Team Govin, Institute for Advanced Biosciences, CNRS UMR5309, INSERM U1209, Université
mBio, Ahead of Print.
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Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus Candida glabrata mBio (IF 6.4) Pub Date : 2024-03-19 Amir ArastehfarFarnaz DaneshniaDaniel J. FloydNathan Elias JeffriesMostafa SalehiDavid S. PerlinMacit IlkitCornelia Lass-FlöerlMichael K. Mansour1Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA2Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA3Institute of Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam, Amsterdam
mBio, Ahead of Print.
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MoMkk1 and MoAtg1 dichotomously regulating autophagy and pathogenicity through MoAtg9 phosphorylation in Magnaporthe oryzae mBio (IF 6.4) Pub Date : 2024-03-19 Yun KongPusheng GuoJiayun XuJiaxu LiMiao WuZiqi ZhangYifan WangXinyu LiuLeiyun YangMuxing LiuHaifeng ZhangPing WangZhengguang Zhang1Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, and Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing, China2The Key Laboratory of Plant Immunity, Nanjing Agricultural University
mBio, Ahead of Print.
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Alternate typhoid toxin assembly evolved independently in the two Salmonella species mBio (IF 6.4) Pub Date : 2024-03-19 Antonio J. ChemelloCasey C. Fowler1Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada, Samuel I. Miller
mBio, Ahead of Print.
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ACE-2-like enzymatic activity is associated with immunoglobulin in COVID-19 patients mBio (IF 6.4) Pub Date : 2024-03-19 Yufeng SongRegan MyersFrances MehlLila MurphyBailey BrooksJeffrey M. WilsonAlexandra KadlJudith WoodfolkSteven L. Zeichner1Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA2College of Arts and Sciences, University of Virginia, Charlottesville, Virginia, USA3Division of Allergy and Clinical Immunology, Department of Medicine, University of Virginia, Charlottesville, Virginia
mBio, Ahead of Print.
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Type 1 fimbriae-mediated collective protection against type 6 secretion system attacks mBio (IF 6.4) Pub Date : 2024-03-18 Margot Marie Dessartine, Artemis Kosta, Thierry Doan, Éric Cascales, Jean-Philippe Côté
Type 6 secretion systems (T6SS) are molecular weapons employed by gram-negative bacteria to eliminate neighboring microbes. T6SS plays a pivotal role as a virulence factor, enabling pathogenic gram-negative bacteria to compete with the established ...
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Nuclear factor kappa B-dependent persistence of Salmonella Typhi and Paratyphi in human macrophages mBio (IF 6.4) Pub Date : 2024-03-18 Taylor A. StepienLarissa A. SingletaryFermin E. GuerraJoyce E. KarlinseyStephen J. LibbySarah L. JaslowMargaret R. GaggioliKyle D. GibbsDennis C. KoMichael A. BrehmDale L. GreinerLeonard D. ShultzFerric C. Fang1Department of Global Health, University of Washington, Seattle, Washington, USA2Department of Microbiology, University of Washington, Seattle, Washington, USA3Department of Laboratory Medicine
mBio, Ahead of Print.
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Comparison of metagenomic and traditional methods for diagnosis of E. coli enteric infections mBio (IF 6.4) Pub Date : 2024-03-15 C. RoyerN. V. PatinK. J. JesserA. Peña-GonzalezJ. K. HattG. TruebaK. LevyK. T. Konstantinidis1School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA2Department of Environmental and Occupational Health, University of Washington, Seattle, Washington, USA3Max Planck Tandem Group in Computational Biology, Department of Biological Sciences, Universidad de los Andes, Bogotà
mBio, Ahead of Print.
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Is Candida auris the first multidrug-resistant fungal zoonosis emerging from climate change? mBio (IF 6.4) Pub Date : 2024-03-13 Victor Garcia-Bustos1Severe Infection Research Group, Health Research Institute La Fe, Valencia, Spain2Instituto Universitario de Sanidad Animal y Seguridad Alimentaria (IUSA), Universidad de Las Palmas de Gran Canaria, Arucas, Spain3Department of Internal Medicine and Infectious Diseases, University and Polytechnic Hospital La Fe, Valencia, Spain, J. Andrew Alspaugh
mBio, Ahead of Print.
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The impact of orphan histidine kinases and phosphotransfer proteins on the regulation of clostridial sporulation initiation mBio (IF 6.4) Pub Date : 2024-03-13 Iman Mehdizadeh GohariAdrianne N. EdwardsShonna M. McBrideBruce A. McClane1Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA2Department of Microbiology and Immunology, Emory University School of Medicine, Emory Antibiotic Resistance Center, Atlanta, Georgia, USA, Jacob YountDaniel Paredes-Sabja
mBio, Ahead of Print.
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Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicating mBio (IF 6.4) Pub Date : 2024-03-13 Nikhila S. TannetiAnant K. PatelLi Hui TanAndrew D. MarquesRanawaka A. P. M. PereraScott Sherrill-MixBrendan J. KellyDavid M. RennerRonald G. CollmanKyle RodinoCarole LeeFrederic D. BushmanNoam A. CohenSusan R. Weiss1Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA2Department of Otorhinolaryngology- Head and Neck Surgery, Perelman School
mBio, Ahead of Print.
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Novel spore-forming species exhibiting intrinsic resistance to third- and fourth-generation cephalosporins and description of Tigheibacillus jepli gen. nov., sp. nov. mBio (IF 6.4) Pub Date : 2024-03-13 Georgios MiliotisPratyay SenguptaAsif HameedMaria ChuvochinaFrancesca McDonaghAnna C. SimpsonCeth W. ParkerNitin K. SinghPunchappady D. RekhaDearbháile MorrisKarthik RamanNikos C. KyrpidesPhilip HugenholtzKasthuri Venkateswaran1Antimicrobial Resistance and Microbial Ecology Group, School of Medicine, University of Galway, Galway, Ireland2Centre for One Health, Ryan Institute, University of Galway,
mBio, Ahead of Print.
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SP-CHAP, an endolysin with enhanced activity against biofilm pneumococci and nasopharyngeal colonization mBio (IF 6.4) Pub Date : 2024-03-12 Adit B. AlrejaAmanda E. AppelJinyi C. ZhuSean P. RileyNorberto Gonzalez-JuarbeDaniel C. Nelson1Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, USA2Department of Infectious Diseases and Genomic Medicine, J. Craig Venter Institute, Rockville, Maryland, USA3Department of Veterinary Medicine, University of Maryland, College Park, Maryland, USA4Department
mBio, Ahead of Print.
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Redefining development in Streptomyces venezuelae: integrating exploration into the classical sporulating life cycle mBio (IF 6.4) Pub Date : 2024-03-12 Evan M. F. ShepherdsonMarie A. Elliot1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada2Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada3Department of Biology, McMaster University, Hamilton, Ontario, Canada, Lotte Søgaard-Andersen
mBio, Ahead of Print.
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Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut mBio (IF 6.4) Pub Date : 2024-03-12 Joana GaifemAna Mendes-FriasMathis WolterAlex SteimleMaria Jose GarzónCarles UbedaClarisse NobreAbigail GonzálezSalomé S. PinhoCristina CunhaAgostinho CarvalhoAntónio Gil CastroMahesh S. DesaiFernando RodriguesRicardo Silvestre1Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal2ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães
mBio, Ahead of Print.
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Plasmodium falciparum selectively degrades α-spectrin of infected erythrocytes after invasion mBio (IF 6.4) Pub Date : 2024-03-12 Kexin ZhengQilong LiNing JiangYanxin ZhangYuxin ZhengYiwei ZhangYing FengRan ChenXiaoyu SangQijun Chen1Key Laboratory of Livestock Infectious Diseases, Ministry of Education, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China2Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College
mBio, Ahead of Print.
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Tetramerization is essential for the enzymatic function of the Pseudomonas aeruginosa virulence factor UDP-glucose pyrophosphorylase mBio (IF 6.4) Pub Date : 2024-03-12 Larissa DirrSven CleevesIsabel Ramón RothLinghui LiTimm FiebigThomas VeSusanne HäusslerArmin BraunMark von ItzsteinJana I. Führing1Institute for Glycomics, Gold Coast Campus, Griffith University, Gold Coast, Queensland, Australia2Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR), Hannover, Germany3Biomedical
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The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication mBio (IF 6.4) Pub Date : 2024-03-12 Janine VetterGuido PapaKurt ToblerJavier M. RodriguezManuel KleyMichael MyersMahesa WiesendangerElisabeth M. SchranerDaniel LuqueOscar R. BurroneCornel FraefelCatherine Eichwald1Institute of Virology, University of Zurich, Zurich, Switzerland2Molecular Immunology Lab, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy3Department of Structure of Macromolecules, Centro Nacional
mBio, Ahead of Print.
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Wall teichoic acid substitution with glucose governs phage susceptibility of Staphylococcus epidermidis mBio (IF 6.4) Pub Date : 2024-03-12 Christian BeckJanes KruscheAnna NotaroAxel WalterLara KränkelAnneli VollertRegine StemmlerJohannes WittmannMartin SchallerChristoph SlavetinskyChristoph MayerCristina De CastroAndreas Peschel1Cluster of Excellence “Controlling Microbes to Fight Infections (CMFI)”, University of Tübingen, Tübingen, Germany2Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Infection Biology, University
mBio, Ahead of Print.
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The inner membrane protein YhiM links copper and CpxAR envelope stress responses in uropathogenic E. coli mBio (IF 6.4) Pub Date : 2024-03-12 Panatda Saenkham-HuntsingerMatthew RitterGeorge L. DonatiAngela M. MitchellSargurunathan Subashchandrabose1Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA2Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina, USA3Department of Biology, College of Science, Texas A&M University,
mBio, Ahead of Print.
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Alternative substitutions of N332 in HIV-1AD8 gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting the V3-glycan mBio (IF 6.4) Pub Date : 2024-03-12 Jeffy JeffyDurgadevi ParthasarathyShamim AhmedHéctor Cervera-BenetUlahn XiongMiranda HarrisDmitriy MazurovStephanie PickthornAlon Herschhorn1Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA2Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA3Institute for Engineering in Medicine
mBio, Ahead of Print.
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Tracing the STING exocytosis pathway during herpes viruses infection mBio (IF 6.4) Pub Date : 2024-03-12 Christos DogrammatzisRabina SaudHope WaisnerSarah LasnierSreenath Muraleedharan SumaBrandon GrieshaberMaria Kalamvoki1Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA, Nihal Altan-BonnetAlan G. Goodman
mBio, Ahead of Print.
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Control of three-carbon amino acid homeostasis by promiscuous importers and exporters in Bacillus subtilis: role of the “sleeping beauty” amino acid exporters mBio (IF 6.4) Pub Date : 2024-03-12 Robert WarnekeChristina HerzbergRichard DanielBjörn HormesJörg Stülke1Department of General Microbiology, Institute for Microbiology and Genetics, GZMB, Georg-August-University, Göttingen, Germany2Center for Bacterial Cell Biology, Biosciences Institute, Medical Faculty, Newcastle University, Newcastle Upon Tyne, United Kingdom, Erhard Bremer
mBio, Ahead of Print.
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SARS-CoV-2 Omicron infection augments the magnitude and durability of systemic and mucosal immunity in triple-dose CoronaVac recipients mBio (IF 6.4) Pub Date : 2024-03-08 Yuxin ChenTiantian ZhaoLin ChenGuozhi JiangYu GengWanting LiShengxia YinXin TongYue TaoJun NiQiuhan LuMingzhe NingChao Wu1Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China2Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, Jiangsu, China3Department of Infectious Diseases, Nanjing
mBio, Ahead of Print.
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Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum mBio (IF 6.4) Pub Date : 2024-03-08 Stella Y. SunLi-av Segev-ZarkoGrigore D. PintilieChi Yong KimSophia R. StaggersMichael F. SchmidElizabeth S. EganWah ChiuJohn C. Boothroyd1Department of Structural Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA2Department of Bioengineering, James H. Clark Center, Stanford University, Stanford, California, USA3Department of Microbiology and Immunology, Stanford University School of
mBio, Ahead of Print.
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Regulation of phase separation and antiviral activity of Cactin by glycolytic enzyme PGK via phosphorylation in Drosophila mBio (IF 6.4) Pub Date : 2024-03-06 Dongchao ChenChang ShiWen XuQiqi RongQingfa Wu1Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China2Division of Molecular Medicine, CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science and Technology of China, Hefei, Anhui, China3Anhui Provincial Key Laboratory
mBio, Ahead of Print.
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The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinum mBio (IF 6.4) Pub Date : 2024-03-06 Kathleen R. NicholsonRachel M. CroninRebecca J. PrestAruna R. MenonYuwei YangMadeleine K. JennischMatthew M. ChampionDavid M. TobinPatricia A. Champion1Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana, USA2Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Office of Vaccines Research
mBio, Ahead of Print.
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Hopanoid lipids promote soybean–Bradyrhizobium symbiosis mBio (IF 6.4) Pub Date : 2024-03-06 Huiqiao PanAshley ShimMatthew B. LubinBrittany J. Belin1Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland, USA2Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA, Arash Komeili
mBio, Ahead of Print.
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Rickettsia rickettsii virulence determinants RARP2 and RapL mitigate IFN-β signaling in primary human dermal microvascular endothelial cells mBio (IF 6.4) Pub Date : 2024-03-06 Liam FitzsimmonsDeAnna BublitzTina ClarkTed Hackstadt1Host-Parasite Interactions Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA, Craig R. Roy
mBio, Ahead of Print.
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Integrating high-throughput analysis to create an atlas of replication origins in Trypanosoma cruzi in the context of genome structure and variability mBio (IF 6.4) Pub Date : 2024-03-05 Marcela de Oliveira VitarelliThiago Andrade FrancoDavid da Silva PiresAlex Ranieri Jerônimo LimaVincent Louis VialaAmelie Johanna KrausInácio de Loiola Meirelles Junqueira de AzevedoJulia Pinheiro Chagas da CunhaMaria Carolina Elias1Cell Cycle Laboratory, Butantan Institute, Av. Vital Brazil, São Paulo, Brazil2Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, Av. Vital
mBio, Ahead of Print.
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Human otic progenitor cell models of congenital hearing loss reveal potential pathophysiologic mechanisms of Zika virus and cytomegalovirus infections mBio (IF 6.4) Pub Date : 2024-03-05 Alfred T. HardingKaren OcwiejaMinjin JeongYichen ZhangValerie LegerNairuti JhalaKonstantina M. StankovicLee Gehrke1Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA2Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA3Boston Childrens’ Hospital, Boston, Massachusetts, USA4Department of Otolaryngology-Head and
mBio, Ahead of Print.
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A human milk oligosaccharide prevents intestinal inflammation in adulthood via modulating gut microbial metabolism mBio (IF 6.4) Pub Date : 2024-03-05 Kasey M. SchalichMatthew A. BuendiaHarpreet KaurYash A. ChoksiM. Kay WashingtonGabriela S. CodreanuStacy D. SherrodJohn A. McLeanRichard M. Peek, Jr.Sari A. AcraSteven D. TownsendFang Yan1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA2Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA3Department of Pathology, Microbiology
mBio, Ahead of Print.
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Stat3 activation-triggered transcriptional networks govern the early stage of HBV-induced hepatic inflammation mBio (IF 6.4) Pub Date : 2024-03-05 Jinglin TangJiaxuan ZhangGaoli ZhangWenhui PengNing LingYingzhi ZhouHongmei XuHong RenMin Chen1Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China2Department of Infection, Ministry of Education Key Laboratory of Child Development
mBio, Ahead of Print.
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Estradiol mediates greater germinal center responses to influenza vaccination in female than male mice mBio (IF 6.4) Pub Date : 2024-03-05 Santosh Dhakal, Han-Sol Park, Kumba Seddu, John S. Lee, Patrick S. Creisher, Brittany Seibert, Kimberly M. Davis, Isabella R. Hernandez, Robert W. Maul, Sabra L. Klein
Females of reproductive ages develop greater antibody responses to influenza vaccines than males. We hypothesized that female-biased immunity and protection against influenza were mediated by estradiol signaling in B cells. Using diverse mouse models ...
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Transcriptome fine-mapping in Fusobacterium nucleatum reveals FoxJ, a new σE-dependent small RNA with unusual mRNA activation activity mBio (IF 6.4) Pub Date : 2024-03-04 Falk PonathYan ZhuJörg Vogel1Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany2RNA Biology Group, Institute for Molecular Infection Biology (IMIB), University of Würzburg, Würzburg, Germany, Carmen Buchrieser
mBio, Ahead of Print.
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Stoichiometry for entry and binding properties of the Env protein of R5 T cell-tropic HIV-1 and its evolutionary variant of macrophage-tropic HIV-1 mBio (IF 6.4) Pub Date : 2024-03-01 Xavier BonnerAmy SondgerothAmelia McCueNathan NicelyAshutosh TripathyEan SpielvogelMatthew MoeserRuian KeKarin LeidermanSarah B. JosephRonald Swanstrom1Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA3T-6, Theoretical
mBio, Ahead of Print.
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Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology mBio (IF 6.4) Pub Date : 2024-03-01 Drake T. PhilipNigel M. GoinsNicholas J. CatanzaroIchiro MisumiJason K. WhitmireHannah M. AtkinsHelen M. Lazear1Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA2Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA3Department of Genetics, University of
mBio, Ahead of Print.
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How P. aeruginosa cells with diverse stator composition collectively swarm mBio (IF 6.4) Pub Date : 2024-03-01 Jaime de AndaSherry L. KuchmaShanice S. WebsterArman BoromandKimberley A. LewisCalvin K. LeeMaria ContrerasVictor F. Medeiros PereiraWilliam SchmidtDeborah A. HoganCorey S. O’HernGeorge A. O’TooleGerard C. L. Wong1Department of Bioengineering, University of California Los Angeles, Los Angeles, California, USA2Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles
mBio, Ahead of Print.
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Reduced peptidoglycan synthesis capacity impairs growth of E. coli at high salt concentration mBio (IF 6.4) Pub Date : 2024-03-01 Dema AlodainiVictor Hernandez-RocamoraGabriela BoelterXuyu MaMicheal B. AlaoHannah M. DohertyJack A. BryantPatrick MoynihanDanesh MoradigaravandMonika GlinkowskaWaldemar VollmerManuel Banzhaf1Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, United Kingdom2Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne
mBio, Ahead of Print.
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Deep-sea in situ and laboratory multi-omics provide insights into the sulfur assimilation of a deep-sea Chloroflexota bacterium mBio (IF 6.4) Pub Date : 2024-02-28 Rikuan ZhengChong WangChaomin Sun1CAS and Shandong Province Key Laboratory of Experimental Marine Biology & Center of Deep Sea Research, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China2Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, China3Center of Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China4College of
mBio, Ahead of Print.
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Cooperation between two modes for DNA replication initiation in the archaeon Thermococcus barophilus mBio (IF 6.4) Pub Date : 2024-02-29 Logan Mc TeerYann MoalicValérie Cueff-GauchardRyan CatchpoleGaëlle HogrelYang LuSébastien LaurentMarie HemonJohanne AubéElodie LeroyErwan RousselJacques ObertoDidier FlamentRémi Dulermo1Univ Brest, Ifremer, CNRS, UMR6197 Biologie et Ecologie des Ecosystèmes marins Profonds (BEEP), Plouzané, France2LabISEN, Yncréa Ouest, Brest, France3Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology
mBio, Ahead of Print.
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Ceramide-1-phosphate is a regulator of Golgi structure and is co-opted by the obligate intracellular bacterial pathogen Anaplasma phagocytophilum mBio (IF 6.4) Pub Date : 2024-02-28 Curtis B. Read Anika N. Ali Daniel J. Stephenson H. Patrick Macknight Kenneth D. Maus Chelsea L. Cockburn Minjung Kim Xiujie Xie Jason A. Carlyon Charles E. Chalfant 1 Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine , Richmond, Virginia, USA 2 Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida
mBio, Ahead of Print.
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Increased production of aureolysin and staphopain A is a primary determinant of the reduced virulence of Staphylococcus aureus sarA mutants in osteomyelitis mBio (IF 6.4) Pub Date : 2024-02-28 Mara J. CampbellKaren E. BeenkenAura M. RamirezMark S. Smeltzer1Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA, Steven J. Projan
mBio, Ahead of Print.