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Correlation between in vitro anti-urease activity and in silico molecular modeling approach of novel imidazopyridine–oxadiazole hybrids derivatives Open Chem. (IF 2.3) Pub Date : 2024-03-27 Shoaib Khan, Rafaqat Hussain, Yousaf Khan, Tayyiaba Iqbal, Tariq Aziz, Metab Alharbi
In the current era, a potent drug is still needed on the market for the treatment of various diseases worldwide. Researchers mainly focus on those enzymes that cause these diseases. One of the major diseases is caused by an enzyme called urease, which increases the concentration of ammonia in the body upon hydrolysis. Researchers across the globe have keen interest to synthesize the potent inhibitor
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Microbial dynamics and dehydrogenase activity in tomato (Lycopersicon esculentum Mill.) rhizospheres: Impacts on growth and soil health across different soil types Open Chem. (IF 2.3) Pub Date : 2024-03-26 Kamal Hassan Suliman, Abdel-Rhman Z. Gaafar, Abdelmalik M. Abdelmalik, Bandar M. AlMunqedhi, Abdalla Elzein, Mohamed S. Hodhod
The dehydrogenase activity (DHA) in the rhizospheres of tomatoes grown in different soil types – Khor Abu-Habil (KA), Bara (B), and Greenhouse (Gr) – in North Kordofan, Sudan, was determined. In addition, the abundance of soil microbes in the tomato rhizospheres during the two growth stages, after 45 and 90 days (short and long term), was analyzed. The KA site (clay soil) showed the highest DHA (81
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Computational design and in vitro assay of lantadene-based novel inhibitors of NS3 protease of dengue virus Open Chem. (IF 2.3) Pub Date : 2024-03-23 Somdutt Mujwar, Jyoti Pal, Manu Sharma, Abhishek Tiwari, Varsha Tiwari, Manish Kumar, Shivani Verma, Ashraf Ahmed Qurtam, Fahd A. Nasr, Mohammed Al-Zharani, Abdulsalam Alhalmi
Dengue virus (DENV) infection is one of the diseases for which no drug is available for the treatment. The DENV NS2B-NS3 protease is considered to be the prime target for anti-dengue drug development because of its importance in the development of new virus subunits via DENV poly-protein breakdown. Pentacyclic triterpenoids (Lantadenes) from the weed Lantana camara L. and its semi-synthetic congeners
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Anti-parasitic activity and computational studies on a novel labdane diterpene from the roots of Vachellia nilotica Open Chem. (IF 2.3) Pub Date : 2024-03-23 Naser F. Al-Tannak, John V. Anyam, Eman Y. Santali, Alexander I. Gray, Collins U. Ibeji, John O. Igoli
A new labdane diterpene characterized as 18α-O-trans-p-feruloyl-15-methyl-8(17)-labdanoate has been isolated from the roots of Vachellia nilotica. Also isolated were p-coumaric acid, ferulic acid, stearic acid, lupeol, and a mixture of β-sitosterol and stigmasterol. The compounds were obtained after a series of column chromatography on silica gel, and their structures were elucidated using NMR and
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Structural aspects of Pt(η3-X1N1X2)(PL) (X1,2 = O, C, or Se) and Pt(η3-N1N2X1)(PL) (X1 = C, S, or Se) derivatives Open Chem. (IF 2.3) Pub Date : 2024-03-22 Melník Milan, Mikušová Veronika, Mikuš Peter
This article covers 26 Pt(ii) complexes of compositions Pt(η3-X1N1X2)(PL) (X1,2 = O, C, or Se) and Pt(η3-N1N2X1)(PL) (X1 = C, S, or Se). These complexes crystallized in two crystal classes: monoclinic (14 examples) and triclinic (12 examples). The heterotridentate ligand with monodentate PL builds up a distorted square-planar geometry around each Pt(ii) atom. Each heterotridentate ligand Pt(η3-X1N1X2)(PL)
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Chemical composition and bioactivities of the methanol root extracts of Saussurea costus Open Chem. (IF 2.3) Pub Date : 2024-03-21 Manal Abdulaziz Binobead, Ibrahim M. Aziz, Sobhy M. Ibrahim, Reem M. Aljowaie
Saussurea costus (S. costus) is a medicinal plant from the Asteraceae family that is widely used in traditional medicine in Saudi Arabia. This study examines S. costus root extract for its chemical composition and its antioxidant, anti-cancer, and antibacterial properties. The results of the study on the methanol root extract of S. costus reveal a rich chemical composition, as identified by GC-MS/FID
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A comprehensive review uncovering the anticancerous potential of genkwanin (plant-derived compound) in several human carcinomas Open Chem. (IF 2.3) Pub Date : 2024-03-21 Pratibha Pandey, Seema Ramniwas, Meenakshi Verma, Indra Rautela, Fahad Khan, Mohd Asif Shah
Plant-derived bioactive compounds displayed major therapeutic and chemo-preventive roles in the pathogenesis of numerous chronic malignancies such as cancer and enhanced oxidative stress and inflammation. Antioxidants found in food, such as genkwanin, may reduce oxidative stress and the release of cytokines or pathways that promote inflammation. The goal of this work is to summarize the potential for
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Determination of essential oil and chemical composition of St. John’s Wort Open Chem. (IF 2.3) Pub Date : 2024-03-21 Hülya Doğan, Hafize Fidan, Hatice Baş, Stanko Stankov, Albena Stoyanova, Sezai Ercisli, Amine Assouguem, Riaz Ullah, Ahmed Bari
Considering it contains a variety of physiologically active compounds, including flavonoids, common phenols, and essential oils (EOs), St. John’s wort (Hypericum perforatum L.) is a common plant in Bulgaria that is predominantly used in folk medicine to cure various disorders. Determining the chemical makeup of St. John’s wort inflorescences that were gathered from northern Bulgaria was the purpose
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Nutraceutical potential of Mesembryanthemum forsskaolii Hochst. ex Bioss.: Insights into its nutritional composition, phytochemical contents, and antioxidant activity Open Chem. (IF 2.3) Pub Date : 2024-03-18 Ahmed A. Qahtan, Abdulrahman A. Alatar
Mesembryanthemum forsskaolii Hochst. ex Bioss is a resilient succulent plant in the Aizoaceae family. This plant has been recognized for its nutritional and metabolic benefits, but its potential remains underexplored. The aim of this research is to analyze the nutritional composition, phytochemical content, and antioxidant potential of M. forsskaolii. The protein content, total sugars, macro-, and
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Hollow mushroom nanomaterials for potentiometric sensing of Pb2+ ions in water via the intercalation of iodide ions into the polypyrrole matrix Open Chem. (IF 2.3) Pub Date : 2024-03-18 Maha Abdallah Alnuwaiser, Mohamed Rabia
Herein, the synthesis of a sensor for the determination of lead (Pb2+) ions via the intercalation of iodide ions into the polypyrrole matrix is performed. It demonstrated a Nernstian slope of 31.7 mV/decade, indicating a linear response within the concentration range of 10−5–10−1 M. The detection limit achieved is 9.10−6 M, indicating the sensor’s sensitivity to low concentrations of Pb2+. The effectiveness
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The effect of gamma radiation on 5-hydroxymethylfurfural conversion in water and dimethyl sulfoxide Open Chem. (IF 2.3) Pub Date : 2024-03-13 Nurulsafeelanaria Benwannamas, Phongphak Sataman, Somprasong Thongkham, Wilasinee Kingkam, Wiranee Sriwiang, Sakchai Laksee, Nicha Prigyai, Tanagorn Sangtawesin, Threeraphat Chutimasakul
5-Hydroxymethylfurfural (HMF) is a biomass-based chemical platform that can undergo many feasible reactions. One of the most important reactions is the oxidation to 2,5-furandicarboxylic acid (FDCA), which is the monomer for bioplastic production. In this work, the radiation method was used to investigate the conversion of HMF in both aqueous (DI) and dimethyl sulfoxide (DMSO) solutions. The effects
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Evaluation of influence of Butea monosperma floral extract on inflammatory biomarkers Open Chem. (IF 2.3) Pub Date : 2024-03-06 Nureen Zahra, Aansa Mazhar, Beenish Zahid, Muhammad Ahsan Naeem, Abid Sarwar, Tariq Aziz, Metab Alharbi, Thamer H. Albekairi, Abdullah F. Alasmari
Butea monosperma is a deciduous tree, widely distributed throughout India, Burma, and Ceylon. The present study was intended to investigate the anti-inflammatory effects of Butea monosperma on the induced inflammatory model by evaluating pro-inflammatory biomarkers and their computational analysis. The anti-inflammatory activity may be attributed to the phyto-constituents for inhibitory effects on
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Cannabis sativa L. essential oil: Chemical composition, anti-oxidant, anti-microbial properties, and acute toxicity: In vitro, in vivo, and in silico study Open Chem. (IF 2.3) Pub Date : 2024-03-06 Rafik El-Mernissi, Naoual El Menyiy, Rania Moubachir, Aziz Zouhri, Yahya El-Mernissi, Farhan Siddique, Sumaira Nadeem, Hind Ibork, Azeddin El Barnossi, Gezahign Fentahun Wondmie, Mohammed Bourhia, Yousef A. Bin Jardan, Oualid Abboussi, Lhoussain Hajji
This study evaluated the volatile components of Cannabis sativa L. essential oils (CSEOs) and their pharmacological potential in vitro, in animal, and in silico. The anti-oxidant capacities of volatile compounds were tested using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), total anti-oxidant capacity (TAC), and gas chromatography-mass spectrometry (GC-MS). Anti-microbial
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Synthesis of multi-template molecularly imprinted polymers (MT-MIPs) for isolating ethyl para-methoxycinnamate and ethyl cinnamate from Kaempferia galanga L., extract with methacrylic acid as functional monomer Open Chem. (IF 2.3) Pub Date : 2024-03-05 Ike Susanti, Anastasya Leatemia Triadenda, Niky Murdaya, Driyanti Rahayu, Rimadani Pratiwi, Yudi Rosandi, Aliya Nur Hasanah
Kaempferia galanga L. extract contains ethyl p-methoxycinnamate (EPMC) and ethyl cinnamate (EC), which have several pharmacological activities. EPMC and EC have been successfully isolated, but the %yield was low. Therefore, developing an isolation method to increase the %yield result of EPMC and EC is essential. The molecularly imprinted polymers have been applied to separate lot of active compounds
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In vivo protective effects of vitamin C against cyto-genotoxicity induced by Dysphania ambrosioides aqueous extract Open Chem. (IF 2.3) Pub Date : 2024-03-05 Laila El-Bouzidi, Ahmed khadra, Manal Zefzoufi, Saida Sissi, Abdelilah El-Abbassi, Khalid Bekkouche, Souad Sellami, Hanane Rais
Dysphania ambrosioides (L.) holds a prominent place in Moroccan folk medicine due to its therapeutic attributes. Despite its widespread use, instances of inadvertent intoxication linked to its consumption have been reported. This study aims to evaluate the potential cytogenotoxic effects of D. ambrosioides leaf aqueous extract (DAAE) and explore the prospective protective role of vitamin C (l-ascorbic
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Phytochemical and physicochemical studies of different apple varieties grown in Morocco Open Chem. (IF 2.3) Pub Date : 2024-03-01 Kara Mohammed, Hamza Saghrouchni, Youness El Abdali, Assouguem Amine, Nouha Haoudi, Mohamed El fadili, Aya Amar, Tareq Hamijo, Isil Var, Riaz Ullah, Zerhouni Abdou Rachid, Bahhou Jamila
The apple is an important part of the human diet and is one of the most popular fruits in Morocco, with varieties that are now suitable for human consumption. This study aims to clarify several aspects of apples, such as their physical and chemical compositions and nutrient profiles. Total polyphenols, flavonoids, tannins, and anthocyanins were determined using spectrophotometer and organic acid compounds
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Two triazole-based coordination polymers: Synthesis and crystal structure characterization Open Chem. (IF 2.3) Pub Date : 2024-02-28 Jing Li, Hongjiang Ren, Jiangtao Li, Liuchang Wang
Here we reported two new triazole-based coordination polymers (CPs), i.e., [Zn(Hdatrz)(μ 2-O)] n (1) together with [Mn(Hdatrz)(C2O4)] n ·n(H2O) (2) (Hdatrz = 3,5-diamino-1,2,4-triazole), which were generated under solvothermal conditions. The influence of different metal ions on the structure and properties of CPs was investigated. The CPs’ whole structures have been completely characterized by the
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Green synthesis, characterization, and application of iron and molybdenum nanoparticles and their composites for enhancing the growth of Solanum lycopersicum Open Chem. (IF 2.3) Pub Date : 2024-02-26 Maria Habib, Hina Fatima, Tauseef Anwar, Huma Qureshi, Samson O. Aisida, Ishaq Ahmad, Iftikhar Ali, Amal M. Al-Mohaimeed, Mohamed S. Elshikh, Sarah Abdul Razak, Asif Kamal
Nanomaterials have become integral in various aspects of agricultural practices, including the development of nano-fertilizers for optimized crop nutrition. This study explores the application of green-synthesized iron (Fe) and molybdenum (Mo) nanoparticles, as well as their composites, using a guava leaf extract (GLE). The focus is on assessing their impact on nitrogen fixation and growth in tomato
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Phytochemical analysis, in vitro antioxidant and antifungal activities of extracts and essential oil derived from Artemisia herba-alba Asso Open Chem. (IF 2.3) Pub Date : 2024-02-23 Faiza EL Hajli, Mohamed Reda Kachmar, Amine Assouguem, Riaz Ullah, Ahmed Bari, Khalil Hammani, Said Chakir, Rachid Lahlali, Essaïd Ait Barka, Ghizlane Echchgadda
Artemisia herba-alba Asso is an endemic plant from North-East Morocco offering a diverse range of pharmacological, cosmetic, and agro-ecological uses. However, Artemisia herba-alba has not been well exploited in the field of plant protection (post-harvest diseases). This is why the main objective of the present study is to evaluate the antifungal and antioxidant activities of extracts or the essential
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Chemical composition and biological properties of Thymus capitatus plants from Algerian high plains: A comparative and analytical study Open Chem. (IF 2.3) Pub Date : 2024-02-22 Noureddine Tamma, Naima Benchikha, Mohammed Messaoudi, Gianluca Caruso, Talha Bin Emran, Ayomide Victor Atoki, Adekunle Ismahil Adeniyi
The Lamiaceae family contains bioactive medicinal compounds mostly used as ornamental plants and traditional medicine, as well as in the food, cosmetics, and pharmaceutical sectors. Common uses include treating high cholesterol, diabetes, respiratory diseases, heart disease, and food poisoning. These medicinal uses were linked to their components and numerous biological properties, including antimicrobial
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Synthesis, characterization, in silico and in vitro studies of novel glycoconjugates as potential antibacterial, antifungal, and antileishmanial agents Open Chem. (IF 2.3) Pub Date : 2024-02-13 Sher Wali Khan, Saira Nayab, Muhammad Naveed Umar, Momin Khan, Anila Iqbal, Nasir Ahmad, Haroon ur Rashid, Muhammad Ishaq Ali Shah, Naila Gulfam, Muhammad Zahoor, Riaz Ullah, Essam A. Ali
In the present work, several new glycoconjugates (8a–e) were generated from glycopyranosyl-α-trichloroacetimidates (sugar-OTCA) as glycosyl donors and dimethyl-l-tartrate as an aglycone acceptor in good to excellent yields. In the synthetic protocol, various monosaccharides were transformed into pentaacetylated derivatives and then into glycopyranosyl-α-trichloroacetimidates. Afterward, the sugar-OTCA
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Sonochemical synthesis of gold nanoparticles mediated by potato starch: Its performance in the treatment of esophageal cancer Open Chem. (IF 2.3) Pub Date : 2024-02-13 Mingwei Liu, Xiaolei Xue, Bikash Karmakar, Waleed Eltantawy, Attalla F. El-kott, Emam M. El. Nashar, Eman M. Abd-Ella
Economically viable and eco-friendly potato starch (PS) was employed to synthesize Au NPs under ultrasound irradiation. PS phytochemicals have the function of a green reductant as well as an efficient stabilizer template to cap and synthesize gold nanoparticles. Transmission electron microscopy (TEM), UV-Vis spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive
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Exploitation of mangliculous marine fungi, Amarenographium solium, for the green synthesis of silver nanoparticles and their activity against multiple drug-resistant bacteria Open Chem. (IF 2.3) Pub Date : 2024-02-12 Mohamed S. Hodhod, Abdel-Rhman Z. Gaafar, Bandar M. AlMunqedhi, Abdalla Elzein, Abdelmalik M. Abdelmalik
The green synthesis pathway for silver nanoparticles (AgNPs) used in bacterial treatment is regarded as crucial because of its cost-effectiveness, nontoxicity, and eco-friendliness. During the present work, the mangliculous marine fungi Amarenographium solium isolated from the Arabian Gulf Coast of Saudi Arabia were utilized for the synthesis of AgNP, through the bio-reduction of aqueous silver nitrate
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Phytochemical study, antioxidant activity, and dermoprotective activity of Chenopodium ambrosioides (L.) Open Chem. (IF 2.3) Pub Date : 2024-02-03 Soufiane Drioua, Otman El-Guourrami, Amine Assouguem, Mouna Ameggouz, Mohammed Kara, Riaz Ullah, Ahmed Bari, Ahmed Zahidi, Azra Skender, Hanane Benzeid, Anass Doukkali
Chenopodium ambrosioides, a member of the Chenopodiaceae family, is renowned for its toxic properties. Despite its toxicity, it has been traditionally utilized in various communities, particularly in pediatric contexts, for its vermifuge, antispasmodic, and antipyretic attributes. This study aims to unravel the phytochemical composition present in organic fractions and aqueous extracts obtained from
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Impact of biogenic zinc oxide nanoparticles on growth, development, and antioxidant system of high protein content crop (Lablab purpureus L.) sweet Open Chem. (IF 2.3) Pub Date : 2024-01-25 Ahmed A. Qahtan, Abdulrahman A. Alatar, Abdalrhaman M. Salih
Lablab (Lablab purpureus L.) Sweet “white” is a vegetable crop belonging to the Fabaceae family, and it has been used in many ways as food, ornamental plant, green manure, and medicinal. In contrast, zinc oxide nanoparticles (ZnO NPs) play an important role in plant growth and development. The aim of this current study was to investigate the impact of biogenic ZnO NPs on the growth, development, and
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Phytochemicals profiling, in vitro and in vivo antidiabetic activity, and in silico studies on Ajuga iva (L.) Schreb.: A comprehensive approach Open Chem. (IF 2.3) Pub Date : 2024-01-23 Mosleh M. Abomughaid, Fatma A. A. El-Shibani, Abdulnaser Kh. Abdulkarim, Amr S. Abouzied, Ghassan M. Sulaiman, Ali M. Abomughayedh, Munira M. F. Abdulsayid, Salim Albukhaty, Naema Elrmali, Ali Z. Al-Saffar, Hend A. El-khawaga, Hamdoon A. Mohammed
Ajuga iva (L.) Schreb. is a well-known antidiabetic medicinal plant used for several traditional medicine aspects in different areas of the world, including Libya. This study includes phytochemical analysis, antidiabetic evaluation, and in silico studies of the plant, A. iva, growing in Libya. The constituents of the plant were profiled using LC-MS/MS-QTOF analysis, and a total of 28 compounds were
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Phytochemical screening and antioxidant activity of Vitex agnus-castus L. Open Chem. (IF 2.3) Pub Date : 2024-01-19 Soufiane Drioua, Hanane Azalmad, Otman El-Guourrami, Mouna Ameggouz, Fatima Zahra Benkhouili, Amine Assouguem, Mohammed Kara, Riaz Ullah, Essam A. Ali, Sezai Ercisli, Hafize Fidan, Hanane Benzeid, Anass Doukkali
This research is dedicated to investigating the antioxidant potential and phytochemical composition of three distinct extracts derived from Vitex agnus-castus L. These extracts, prepared through aqueous (EXA), ethanolic (EXE), and methanolic (EXM) maceration, were chosen based on prior assessments of total polyphenol content in extracts obtained from five solvents with differing polarities: water,
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Biochar from de-oiled Chlorella vulgaris and its adsorption on antibiotics Open Chem. (IF 2.3) Pub Date : 2024-01-18 Wang Feiyan, Zhang Yali, Luo Siling, Chen Zhiqin, Luo Shanshan, Li Wenkui
High-performance biochar was prepared using de-oiled Chlorella vulgaris biomass as the raw material and KOH as the modifying activator. The properties of the biochar as an adsorbent for the removal of tetracycline (TC) and enrofloxacin (ENR) were investigated under different conditions by varying the amount of the Chlorella vulgaris de-oiled biomass (DB) input. The surface structure and physicochemical
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Evaluation of the analgesic and anesthetic properties of silver nanoparticles supported over biodegradable acacia gum-modified magnetic nanoparticles Open Chem. (IF 2.3) Pub Date : 2024-01-18 Binbin Tan, Jun Chen, Wensheng Wang
An ecofriendly and green procedure was adopted to immobilize Ag NPs over acacia gum (GA)-modified magnetic nanoparticles (Fe3O4-GA/Ag NPs) with analgesic and anesthetic properties. In the stepwise modification method, the pre-synthesized Fe3O4 NPs were coated by the gum acacia (GA) that has hydroxyl groups on its backbone and can be used for as a capping, reducing, and stabilizing agent for immobilized
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Treatment of gastric cancer by silver nanoparticles encapsulated by chitosan polymers mediated by Pistacia atlantica extract under ultrasound condition Open Chem. (IF 2.3) Pub Date : 2024-01-11 Song Li, Ya´nan Xu, Fanlu Meng
In this study, we prepared silver nanoparticles (AgNPs) employing ultrasound and chitosan (CS) in the presence of Pistacia atlantica aqueous extract as a non-toxic stabilizing and reducing agent for capping AgNPs with CS in a simple single-step process. The reduction of Ag+ ions into Ag0NPs was indicated by a visual transform in color. UV-Vis studies revealed that the characteristic surface plasmon
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Melanin antibacterial activity of two new strains, SN1 and SN2, of Exophiala phaeomuriformis against five human pathogens Open Chem. (IF 2.3) Pub Date : 2024-01-11 Safaa Benmessaoud, Jaouad Anissi, Mohammed Kara, Amine Assouguem, Younes Gaga, Mouhcine Ajdi, Riaz Ullah, Essam A. Ali, Sezai Ercisli, Hafize Fidan, Sawinder Kaur, Jamila Bahhou
Melanin is an almost ubiquitous pigment of brown to dark black color synthesized by living organisms. It has excellent potential for application in several fields, especially in pharmaceuticals. Yeasts are known for their ability to synthesize pigments, including melanin. These yeasts are considered black yeasts. However, there is little information on the synthesis of melanin by these yeasts. This
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Therapeutic effects of green-formulated gold nanoparticles by Origanum majorana on spinal cord injury in rats Open Chem. (IF 2.3) Pub Date : 2024-01-11 Lifang Jia, Waleed Eltantawy, Mohamed Samir Ahmed Ahmed Zaki, Abulqasim M. Sideeg, Heitham M. Mohammed, Attalla F. El-kott, Diaa Massoud
In a recent study, we evaluated the remedial properties of gold nanoparticles (gold NPs) green-formulated by Origanum majorana on spinal cord injury in rats. UV-Vis, FE-SEM, FT-IR, and TEM tests were applied to characterize the recent gold NPs. The IC50 values of O. majorana, gold NPs, and butylated hydroxytoluene were 382, 250, and 165 µg/mL, respectively, against DPPH. In in vivo tests, 40 male rats
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Wear and corrosion behavior of TiC and WC coatings deposited on high-speed steels by electro-spark deposition Open Chem. (IF 2.3) Pub Date : 2024-01-10 Ersan Mertgenç
Electro-spark deposition (ESD) is one of the most effective methods for improving the surfaces of metallic materials by applying ceramic-based cermet coatings. In this study, TiC and WC coatings were deposited on the surface of AISI M2 high-speed steel using the ESD method. Subsequently, the coated surfaces were examined through microstructure, phase structure, microhardness, friction, wear, and electrochemical
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In vitro protective and anti-inflammatory effects of Capparis spinosa and its flavonoids profile Open Chem. (IF 2.3) Pub Date : 2024-01-10 Ali S. Alqahtani, Fahd A. Nasr, Mohammad Z. Ahmed, Muath Y. Bin Mansour, Abdullah A. Biksmawi, Omar M. Noman, Rashed N. Herqash, Mohammed Al-zharani, Ashraf Ahmed Qurtam, Hassan A. Rudayni
Multiple beneficial effects have been reported to numerous species of Capparis genus. Among these, Capparis spinosa has exhibited several biological benefits, including anti-inflammatory hepatoprotective, antioxidant, and antidiabetic effects. Herein, C. spinosa was extracted with different solvents and the ability of these fractions to suppress nitric oxide (NO) production in RAW 264.7 cells were
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Porous silicon nanostructures: Synthesis, characterization, and their antifungal activity Open Chem. (IF 2.3) Pub Date : 2024-01-09 Marwa Nabil, Mohamed Elnouby, Abdulaziz A. Al-Askar, Przemysław Łukasz Kowalczewski, Ahmed Abdelkhalek, Said I. Behiry
The use of synthetic pesticides has come under scrutiny, and there has been a subsequent shift toward the investigation of alternative methods for the treatment of plant diseases. One notable advancement in this field is the utilization of porous silicon (PS) powder as a sustainable antifungal agent. The synthesis of PS nanoparticle (PS-NP) powder was carried out using the environmentally friendly
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Green synthesis of AgNPs using plant extract and investigation of its anti-human colorectal cancer application Open Chem. (IF 2.3) Pub Date : 2024-01-09 Yuze Zhai, Benjun Wang, Weiwei Han, Bianfang Yu, Jichen Ci, Fan An
Recently, the plant extracts used to synthesize nanoparticles (NPs) have been considered an excellent alternative to physical and chemical ways. The applications of NPs in the fields of agriculture, industry, and medicine are so many and diverse that they cannot be counted. In recent years, silver nanoparticles (AgNPs) have attracted the consideration of several scientists because of their special
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The adsorption of naproxen on adsorbents obtained from pepper stalk extract by green synthesis Open Chem. (IF 2.3) Pub Date : 2024-01-09 Hacer Dolas
This study presented the adsorption of naproxen on adsorbents filled with Cu, Fe, and Cu/Fe nanoparticles (NPs) obtained by the green synthesis method from pepper stem waste. The resulting adsorbents were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy-energy dispersive X-ray spectroscopy, and thermal gravimetric-differential thermal analysis. The amount of naproxen
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Phytochemical analysis and antifungal efficiency of Origanum majorana extracts against some phytopathogenic fungi causing tomato damping-off diseases Open Chem. (IF 2.3) Pub Date : 2024-01-06 Fatimah Al-Otibi, Reem A. Alshahrani, Raedah I. Alharbi, Mohamed Taha Yassin
Plant diseases represent one of the major problems causing yield loss of tomato crops, especially root rot and seedling damping-off diseases caused by some phytopathogenic fungi like Fusarium solani (Fs), F. oxysporum (Fo), and Macrophomina phaseolina (Mp) frequently detected in tomato either alone or in combination infection. The objective of the present study is to assess the antifungal activity
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Nanostructured p-PbS/p-CuO sulfide/oxide bilayer heterojunction as a promising photoelectrode for hydrogen gas generation Open Chem. (IF 2.3) Pub Date : 2024-01-06 Mohamed Zayed, Mamduh J. Aljaafreh, Mohamed Shaban, Mahmoud Hezam, Sodky H. Mohamed, Mohamed Rabia, Mohammad Marashdeh, M. Al-Hmoud, Ashour M. Ahmed
Recently, the photoelectrochemical (PEC) water-splitting reaction for hydrogen (H2) production has been a competitive research route to realize clean and sustainable electric power. In this work, copper oxide (CuO) and PbS thin films were fabricated on commercial glass, respectively, using the techniques of successive ionic-layer adsorption and reaction and chemical bath deposition. These nanostructured
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Characteristics of Langmuir monomolecular monolayers formed by the novel oil blends Open Chem. (IF 2.3) Pub Date : 2024-01-03 Wiktoria Kamińska, Wojciech Cichocki, Hanna Maria Baranowska, Katarzyna Walkowiak, Dominik Kmiecik, Przemysław Łukasz Kowalczewski
The aim of this work was to assess the physical properties of Langmuir monolayers of three new oil blends “RBWg” (obtained by mixing rapeseed oil, black cumin oil, and wheat germ oil), “REp” (rapeseed oil and evening primrose oil), and “CRb” (camelina oil and rice bran oil), as well as to characterize the molecular dynamics of their protons using low-field nuclear magnetic resonance (LF NMR) method
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Unraveling the therapeutic potential of Bombax ceiba roots: A comprehensive study of chemical composition, heavy metal content, antibacterial activity, and in silico analysis Open Chem. (IF 2.3) Pub Date : 2023-12-25 Ali Alrabie, Mohammed ALSaeedy, Arwa Al-Adhreai, Inas Al-Qadsy, Abdel-Basit Al-Odayni, Waseem Sharaf Saeed, Ahmed Hasan, Mazahar Farooqui
This study sought to assess the heavy metal content, phytochemical composition, antibacterial activity, and absorption, distribution, metabolism, and excretion (ADME) properties of Bombax ceiba L. tree. The heavy metal content of the plant roots was determined using inductively coupled plasma-mass spectrometry technique, and it was found that only Cr, Mn, Fe, and Ni concentrations were above the permissible
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Oleic acid and linoleic acid nanosomes boost immunity and provoke cell death via the upregulation of beta-defensin-4 at genetic and epigenetic levels Open Chem. (IF 2.3) Pub Date : 2023-12-23 Gamaleldin I. Harisa, Ibrahim Najashi, Ahmed H. Bakheit, Sabry M. Attia, Fars K. Alanazi, Salim S. Al-Rejaie, Mohamed Mohany
Host defense peptides (HDPs) are encouraged as anticancer and antimicrobial agents. Thus, this study aimed to investigate the effect of oleic acid (OA)- and linoleic acid (LA)-loaded nanosomes on the gene expression of beta-defensin-4 (BD-4) as a member of HDPs. The OA and LA nanosomes were prepared and characterized in terms of particle size and surface charge as lymphatic delivery systems. Afterwards
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Strategies for optimizing the single GdSrFeO4 phase synthesis Open Chem. (IF 2.3) Pub Date : 2023-12-22 Kairat Maratuly Kenges, Ekaterina Alekseevna Tugova
This work provides data on strategies for single GdSrFeO4 phase solid state synthesis. Earlier works have shown that under the solid-state synthesis conditions, the GdSrFeO4 preparation is hampered by the formation of non-target product: Gd2SrFe2O7. This work approach led to the solid-phase synthesis GdSrFeO4 scheme change. GdSrFeO4 was characterized by X-Ray, scanning electron microscopy/energy dispersive
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Characteristics, source, and health risk assessment of aerosol polyaromatic hydrocarbons in the rural and urban regions of western Saudi Arabia Open Chem. (IF 2.3) Pub Date : 2023-12-21 Mohamed I. Orif, Mohammad S. El-Shahawi, Iqbal M. I. Ismail, Hassan Alshemmari, Ahmed Rushdi, Mohammed A. El-Sayed
Air quality represents one of the most important parameters determining indoor microclimate and human comfort. Thus, the current study reports a comprehensive study on the dominant sources, organic compositions, and potential health impacts of the polyaromatic hydrocarbons (PAHs) in the atmospheric particle matters (PMs) ranging from 2.5 µm (PM2.5) to 10 µm (PM10) size in the rural and urban regions
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Evaluation and chemical characterization of bioactive secondary metabolites from endophytic fungi associated with the ethnomedicinal plant Bergenia ciliata Open Chem. (IF 2.3) Pub Date : 2023-12-20 Jiwan Raj Prasai, Senthuran Sureshkumar, Waseem Ahmad, Mohammad Ashraf, Chinnadurai Gopi, Pandy Rajapriya, Abeer S. Aloufi, Nandakumar Natarajan, Mohan Pandi
The objective of this work was to assess the bioactive potential of endophytic fungi, Colletotrichum brevisporum (JPSK3), Pestalotiopsis microspora (JPSK19), and Guignardia mangiferae (JPSK25), from Bergenia ciliata. The antibacterial effects were determined by the well diffusion technique against human pathogens (Staphylococcus aureus, Escherichia coli, Bacillus cereus, and Salmonella typhi) and they
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Advances in the pharmaceutical research of curcumin for oral administration Open Chem. (IF 2.3) Pub Date : 2023-12-20 Cheng Li, Abid Naeem, Jiangwen Shen, Weiwei Zha, Qingyun Zeng, Peng Zhang, Lin Li, Zhenggen Liao, Xulong Chen
Curcumin is an isolated phytopolyphenol pigment found in the Curcuma longa, commonly known as turmeric, with various pharmacological properties. It has many effects, including anti-tumour, anti-inflammatory, anti-bacterial, anti-oxidation, and hypoglycemic properties. However, due to its oral bioavailability, the use of the drug in the clinical environment is limited. Moreover, curcumin’s low bioavailability
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Characteristics, source, and health risk assessment of aerosol polyaromatic hydrocarbons in the rural and urban regions of western Saudi Arabia Open Chem. (IF 2.3) Pub Date : 2023-12-20 Mohamed I. Orif, Mohammad S. El-Shahawi, Iqbal M. I. Ismail, Hassan Alshemmari, Ahmed Rushdi, Mohammed A. El-Sayed
Air quality represents one of the most important parameters determining indoor microclimate and human comfort. Thus, the current study reports a comprehensive study on the dominant sources, organic compositions, and potential health impacts of the polyaromatic hydrocarbons (PAHs) in the atmospheric particle matters (PMs) ranging from 2.5 µm (PM2.5) to 10 µm (PM10) size in the rural and urban regions
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Characterization and antioxidant potential of white mustard (Brassica hirta) leaf extract and stabilization of sunflower oil Open Chem. (IF 2.3) Pub Date : 2023-12-19 Muhammad Riaz, Maria Nawaz, Rahman Qadir, Shabbir Hussain, Taleeha Roheen, Muhammad Afzal, Muhammad Perviaz, Akbar Ali, Tariq Aziz, Metab Alharbi, Thamer H. Albekairi, Abdullah F. Alasmari
The current study aimed to analyze the stabilization of sunflower oil using white mustard (Brassica hirta) leaf extracts as well as their antioxidant potential and cytotoxicity. Selected plant leaves were macerated in different solvents such as n-hexane, chloroform, ethyl acetate, n-butanol, and methanol. The total flavonoid contents, total phenolic contents, the antioxidant activity by DPPH assay
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Treatment of denture stomatitis using iron nanoparticles green-synthesized by Silybum marianum extract Open Chem. (IF 2.3) Pub Date : 2023-12-13 Xiaoming Lin, Cuiping Bu, Jiangling Su
Stomatitis or generalized inflammation of the mouth includes inflammation or pain in the mouth. Natural compounds are one of the best options for stomatitis treatment. Silybum marianum has many medicinal properties in traditional medicine. In recent research, iron nanoparticles were formulated by S. marianum. The research aim was to determine the Fe nanoparticles’ (FeNPs) efficacy in denture stomatitis
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Enhancing photovoltaic efficiency with SQI-Br and SQI-I sensitizers: A comparative analysis Open Chem. (IF 2.3) Pub Date : 2023-12-11 Sultan A. Al-horaibi, Abdel-Basit Al-Odayni, Mohammed ALSaeedy, Fares Hezam Al-Ostoot, Adel Al-Salihy, Jawaher Q. Ghaleb, Arwa Al-Adhreai, Faizaa A. Saif, Salama A. Yaseen, Waseem Sharf Saeed
This study investigates the use of halogen bonding to enhance the effectiveness of short-circuit current density (J SC) in dye-sensitized solar cells (DSSCs). To improve the performance of DSSCs, two dyes, SQI-Br and SQI-I, based on halogen atom-functionalized unsymmetrical squaraine dyes, were designed. These dyes were tested in DSSCs using iodolyte electrolytes (Z-50 and Z-100), and their performance
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Clay-based bricks’ rich illite mineral for gamma-ray shielding applications: An experimental evaluation of the effect of pressure rates on gamma-ray attenuation parameters Open Chem. (IF 2.3) Pub Date : 2023-11-30 K. A. Mahmoud, M. W. Marashdeh
The objective of this study is to increase the natural clay mineral-based bricks’ ability to shield γ-rays without the use of external doping materials. Six brick samples were consequently developed at various pressure rates (PRs). The chemical composition and structure of the manufactured bricks are unaffected by the PR applied. The main constituents in the clay used to make bricks are illite and
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Some anticancer agents as effective glutathione S-transferase (GST) inhibitors Open Chem. (IF 2.3) Pub Date : 2023-11-30 Başak Gökçe
The objective of this research was to investigate the impact of anthraquinone (AQ) compounds on the activity of the enzyme glutathione S-transferase (GST). The interaction between GST and some AQs (alizarin, purpurin, quinizarin, and dantron) was investigated, and IC50 and K i levels were determined for each compound. The results obtained reveal that these compounds are potent GST inhibitors. K i values
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Stability kinetics of orevactaene pigments produced by Epicoccum nigrum in solid-state fermentation Open Chem. (IF 2.3) Pub Date : 2023-11-30 Sawinder Kaur, Paramjit S. Panesar, Sushma Gurumayum, Jyoti Singh, Amine Assouguem, Abderrahim Lazraq, Riaz Ullah, Essam A. Ali, Azra Skender, Prasad Rasane
Orevactaene yellow pigment was produced by solid-state fermentation of broken rice using Epicoccum nigrum. The pigment was extracted using water as a solvent and subjected to stability studies at different temperatures (30, 40, 60, and 80°C), pH (4, 6, and 8), sterilization, and sunlight exposure treatment. The observed data were fitted in the first-order kinetic model. Yellow pigment stability was
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Antibacterial and biofilm prevention metabolites from Acanthophora spicifera Open Chem. (IF 2.3) Pub Date : 2023-11-28 Fitri Budiyanto, Nawal A. Albalawi, Mohamed A. Ghandourah, Tariq R. Sobahi, Magda M. Aly, Hanan F. Althagbi, Samah S. Abuzahrah, Walied M. Alarif
Acanthophora spicifera harbors a diverse array of secondary metabolites with therapeutic potential. The aim of this study is to isolate and characterize secondary metabolites from A. spicifera and then evaluate the antiproliferation, antibacterial, and biofilm prevention properties, followed by an analysis of molecular docking experiments. By employing chromatographic analysis and NMR spectroscopy
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Utilization of computational methods for the identification of new natural inhibitors of human neutrophil elastase in inflammation therapy Open Chem. (IF 2.3) Pub Date : 2023-11-24 Abdulrahim A. Alzain, Fatima A. Elbadwi, Ahmed A. Al-Karmalawy, Rashid Elhag, Wadah Osman, Ramzi A. Mothana
Human neutrophil elastase (HNE) plays a crucial role in causing tissue damage in various chronic and inflammatory disorders, making it a target for treating inflammatory diseases. While some inhibitors of HNE’s activity have been identified, only a few have made it to clinical trials. In this study, computational methods were employed to identify potential natural products (NPs) capable of targeting
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Preparation of newly developed porcelain ceramics containing WO3 nanoparticles for radiation shielding applications Open Chem. (IF 2.3) Pub Date : 2023-11-22 Dalal A. Aloraini, Mohammad Ibrahim Abualsayed, Aljawhara H. Almuqrin, Mohamed Elsafi
We fabricated porcelain ceramics embedded with WO3 nanoparticles (NPs) for radiation shielding applications. The linear attenuation coefficients were experimentally determined to study the efficiency of the manufactured samples against gamma rays. When the thickness increases from 0.5 to 2 cm, there is a reduction in the photon transmission through the ceramics. At 0.662 MeV, the transmission factor
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Treatment of gastric cancer by green mediated silver nanoparticles using Pistacia atlantica bark aqueous extract Open Chem. (IF 2.3) Pub Date : 2023-11-22 Ling Dang, Jian Yang, Sally Negm, Attalla F. El-kott, Ali A. Shati, Heba I. Ghamry, Bikash Karmakar
We herein demonstrate a novel green mediated silver nanoparticles (AgNPs) using Pistacia atlantica bark aqueous extract for the treatment of gastric cancer under in vitro conditions. Physicochemical and structural features of the nanocomposite biomaterial were assessed by several techniques like UV-Vis spectrum, transmission electron spectroscopy, field emission scanning electron microscopy, energy-dispersive
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Effects of green decorated AgNPs on lignin-modified magnetic nanoparticles mediated by Cydonia on cecal ligation and puncture-induced sepsis Open Chem. (IF 2.3) Pub Date : 2023-11-22 Lei Zhou, Yanfen Yao, Quanzhen Wang, Peng Wang, Shan Hong, Li Kong
Sepsis is a common and deadly syndrome that despite all the progress in its control, the death rate caused by it is high. Sepsis is a serious problem that needs immediate attention and treatment. This infection, especially if it is caused by bacteria resistant to several drugs, causes high mortality. About two-thirds of sepsis cases occur in hospitalized patients. Several factors such as increasing
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Protective properties of AgNPs green-synthesized by Abelmoschus esculentus on retinal damage on the virtue of its anti-inflammatory and antioxidant effects in diabetic rat Open Chem. (IF 2.3) Pub Date : 2023-11-21 Fang Tang, Behnam Mahdavi
Eye retinopathy means damage to the retina of the eye, which can have various causes, both congenital and acquired. Diabetes is one of the important causes of eye retinopathy. Retinopathy can develop slowly or quickly, get better on its own, or lead to permanent damage. No treatment is recommended in the early and mild stages. However, close monitoring is essential. Severe form of the disease may require
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Lewis acids as co-catalysts in Pd-based catalyzed systems of the octene-1 hydroethoxycarbonylation reaction Open Chem. (IF 2.3) Pub Date : 2023-11-17 Kairzhan Shalmagambetov, Andrea Vavasori, Gulbanu Zhaksylykova, Fatima Kanapiyeva, Meruyert Zykay, Nurbolat Kudaibergenov
In this work, in order to develop new, efficient, and environmentally friendly methods for the preparation of practically valuable esters of carboxylic acids, the hydroalkoxycarbonylation reaction of octene-1 with various alcohols in the presence of metal–complex catalysts based on palladium phosphine complexes has been studied. Three-component systems based on PdCl2(PPh3)2 containing different ligands