-
-
The Two Janus Faces of CpRu‐Based Deallylation Catalysts and Their Application for in cellulo Prodrug Uncaging Helv. Chimica Acta (IF 1.8) Pub Date : 2024-04-15 Alain Baiyoumy, Robin Vinck, Thomas R. Ward
In the past 18 years, metal‐catalyzed deallylation has proven a useful tool for studying biological processes in cellulo and in the early development of innovative therapeutic catalytic strategies. This reaction is catalyzed by Ru‐piano stool complexes and has been reported to be compatible with air, water, and thiol‐containing compounds such as glutathione. However, little is known about the true
-
Controlled Release of Volatile Enones from Monomeric and Dimeric Thioether, Sulfoxide and Sulfone Profragrances Helv. Chimica Acta (IF 1.8) Pub Date : 2024-04-10 Alain Trachsel, Sabine Leocata, Jean-Yves de Saint Laumer, Andreas Herrmann
Thioether (sulfide) profragrances are readily prepared by 1,4‐addition of alkanethiols to enones (thia‐Michael reaction). Under ambient conditions, they slowly release the parent enones, thus generating a long‐lasting perfumery effect. The fragrance release of profragrances obtained by 1,4‐addition of S, O and N nucleophiles to enones was compared on cotton and on a hard surface for monomeric and dimeric
-
Synthesis of N-substituted Pyrrole-2,5-dicarboxylic Acids from Pyrroles Helv. Chimica Acta (IF 1.8) Pub Date : 2024-04-03 Jan-Simon Jeshua Friedrichs, Luca Schmermund, Corinna Urmann, Volker Sieber
Pyrrole-2,5-dicarboxylic acid (PDCA) is a heterocyclic aromatic dicarboxylic acid that may emerge as a new monomer for polyester production. Compared to its structurally related and bio-based furan-2,5-dicarboxylic acid (FDCA) that is already used for the production of polyethylene furanoate (PEF), PDCA shows excellent potential as its nitrogen can be targeted for further derivatization, thus enabling
-
Total Synthesis of Core 3 & Core 4‐Type Mucin Glycan Derivatives Helv. Chimica Acta (IF 1.8) Pub Date : 2024-04-03 Carmen R Cori, Rachel Hevey
Recent studies have demonstrated the ability of mucin O‐glycans to attenuate virulence in diverse, cross‐kingdom pathogens, sparking interest in their development as a novel therapeutic approach against infection. Although their virulence attenuating activity is evident, mucin glycans obtained from native sources comprise mixtures of several hundred distinct structures, and therefore the specific active
-
Introduction for the Special Collection of Papers in the Honor of the President of the 56th Bürgenstock Conference, Alois Fürstner Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-29 Alois Fürstner
The Bürgenstock Conference is one of the oldest symposia still running in organic chemistry and arguably (one of) the most prestigious one(s). The schedule of the inaugural 1965 meeting, which included lectures by Profs. Vladimir Prelog, Jack Dunitz, Kurt Mislow, John Cornforth, Max Perutz and other giants, was enough to create a legend. On top of this, the founding fathers knew very well how to foster
-
Isolation of Fidaxomicin and Shunt Metabolites from Actinoplanes deccanensis Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-20 Erik Jung, Maja Hunter, Andrea Dorst, Alexander Major, Tatjana Teofilovic, Rolf Müller, Karl Gademann
A protocol for the isolation of the antibiotic fidaxomicin (Fdx) from Actinoplanes deccanensis and the isolation of shunt metabolites from A. deccanensisfdxG2‐ is reported. We constructed the mutant strain A. deccanensisfdxG2‐ by genetic manipulation which enabled the isolation of shunt metabolites as useful starting points for semisynthetic analogues of Fdx. Furthermore, a synthetic protocol for the
-
-
Submonomer Synthesis of Inverse Polyamidoamine (i-PAMAM) Dendrimer Antibacterials Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-14 Hippolyte Personne, Xiaoling Hu, Etienne Bonvin, Jérémie Reusser, Jean-Louis Reymond
-
Does the Central Nitrogen Atom Make a Difference? A Comparison of Non-Coordinating Pyridine and Benzene Spacers in Multitopic Ligands Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-14 Catherine E. Housecroft, Edwin C. Constable
-
Protocol for the Photocatalytic Hydroxyalkenylation of Alkenes Using 1,2‐Bis(phenylsulfonyl)ethylene and Water Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-13 Chen-Yang Tsai, Chun-Yu Chen, Yen-Ku Wu, Ilhyong Ryu
We report on a protocol for the hydroxyalkenylation of alkenes using an acridinium photoredox catalyst in combination with 1,2‐bis(phenylsulfonyl)ethylene and water. Using the protocol, alkenes could be converted into the corresponding 1‐phenylsulfonyl‐4‐hydroxyalkenes in good yields. The hydroxyalkenylation involves the nucleophilic hydroxylation of alkene‐derived radical cations to give β‐hydroxyalkyl
-
A Targeted Approach for the Metabolome Analysis of E. coli Biofilms Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-08 Jan Rockstroh, Sandy Gerschler, Nadin Schultze, Christian Schulze, Martina Wurster, Karen Methling, Sebastian Guenther, Michael Lalk
-
Organocatalytic Enantioselective Synthesis of Chiral Spiro-indoline-pyrazolones through a formal [4+1] Annulation Reaction of 4-Bromopyrazolones and aza-ortho-Quinone Methides Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-06 Laura Carceller-Ferrer, Carlos Rodríguez-Arias, Marc Montesinos-Magraner, Amparo Sanz-Marco, Judit Hostalet-Romero, Gonzalo Blay, José R. Pedro, Carlos Vila
-
A Fluorogenic Substrate for Quinoline Reduction: Pnictogen-Bonding Catalysis in Aqueous Systems Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-06 Giacomo Renno, Qing-Xia Zhang, Antonio Frontera, Naomi Sakai, Stefan Matile
-
Manganese-Mediated Synthesis of NHC-Phosphine Ligand Precursors Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-05 Jérémy Willot, Sana Fatima, Carine Duhayon, Noël Lugan, Yves Canac, Dmitry A. Valyaev
-
Evolution of the Manufacturing Route towards a Key Benzothiophen-2-yl-Boronic Acid Building Block of Rogaratinib Helv. Chimica Acta (IF 1.8) Pub Date : 2024-03-04 Jörg Gries, Johannes Platzek, Holger Paulsen
-
-
Revealing the Indispensable Role of the RFamide Functionality using a Novel Acid Labile Benzofuranone based Amine (ALBA) Linker Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-25 Gemma Mudd, Megan Hendrikse, Steven Shave, Douglas R Houston, Robert P Millar, Manfred Auer
-
Synthesis and Quantitative Analysis of Glycans Conjugated to Gold Nanoparticles Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-20 Kuo-Shiang Liao, Chih-Chuan Kung, Li-Chun Cheng, Cinya Chung, Chi-Huey Wong
-
Andrea Vasella and the Active Site of Glycoside Hydrolases Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-19 Roland Hoos-Michelotti
-
New Selective Inhibitors of α-Glucosidase for the Treatment of Type 2 Diabetes Mellitus Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-14 Takwa Khanchouch, Aurélie Vallin, Urjwan Alali, Mohammed Benazza, Rym Abidi, Véronique Bonnet
-
N-Methyl-N-Alkylaminocyclopentanes: Powerful and Selective β-d-Glucocerebrosidase Inhibitors Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-13 Patrick Weber, Roland Fischer, Seyed A. Nasseri, Bettina M. Pabst, Herwig Prasch, Arnold E. Stütz, Martin Thonhofer, Stephen G. Withers, Werner Windischhofer, Tanja M. Wrodnigg
-
Development of a Novel Measurement Setup to Study and Predict Electrostatic Discharges in Agitated Glass-Lined Vessels Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-12 Benedikt Robert Brönnimann, Daniel Egli-Tedesco, Klaus Schwenzfeuer, Andreas Zogg
-
Benzylic C(sp3)−H Azidation: Copper vs Iron Catalysis Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-09 Angel Rentería-Gómez, Rubén O. Torres-Ochoa, Pierre Palamini, Raphaël Simonet-Davin, Qian Wang, Jérôme Waser, Jieping Zhu
-
Design and Synthesis of Dialkylarylphosphine Urea Ligands and their Application in Palladium-Catalyzed Cross-Coupling Reactions Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-09 Lupita S. Aguirre, Levi T. Litwiller, Alexis N. Lugo, Andy A. Thomas
-
Functionalization of Cubane Formation of C−C and C−Heteroatom Bonds Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-02 Tomohiro Yasukawa, Katja S. Håheim, Janine Cossy
-
A Scalable and Chromatography-Free Synthesis of N,N-Bis(9,9-dimethyl-9H-fluoren-2-yl)-3′,3′,4′,7′-tetramethyl-2′,3′-dihydrospiro[fluorene-9,1′-indene]-2-amine, a new Hole Transport Material for Organic Solar Cells Helv. Chimica Acta (IF 1.8) Pub Date : 2024-02-02 Yves Aeschi, Thorsten M. Beck, Ulrich Berens, Alexander Ernst
-
Novel Rearrangements of Guaiane Sesquiterpenes Helv. Chimica Acta (IF 1.8) Pub Date : 2024-01-29 Paul L. Türtscher, Gerhard Brunner, Andreas Goeke
-
Synthesis and Cell-Based Evaluation of Umifenovir Analogues as Anti-SARS-CoV-2 Agents Helv. Chimica Acta (IF 1.8) Pub Date : 2024-01-18 Hiroaki Tanaka, Seiya Miyagi, Tomoko Morita, Hiroaki Ishii, Natsuki Mori, Kaho Oishi, Takemasa Sakaguchi, Toyonobu Usuki
-
Enhancing the Metalating Power of ZnEt2 via Formation of an Alkyl/Alkoxide Potassium Zincate Helv. Chimica Acta (IF 1.8) Pub Date : 2024-01-12 Jasmin Kocher, Neil R. Judge, Eva Hevia
-
Selective Recognition of Aromatic Amino Acids by a Molecular Cleft in Water Helv. Chimica Acta (IF 1.8) Pub Date : 2024-01-10 Joël F. Keller, Michal Valášek, Marcel Mayor
-
Synthesis and Photophysical Evaluation of 3,3’-Nitrogen Bis-Substituted fac-[Re(CO)3(Diimine)Br] Complexes Helv. Chimica Acta (IF 1.8) Pub Date : 2024-01-09 Joshua Csucker, Nathalie Decrausaz, Sarah Isabella Jäggi, Olivier Blacque, Bernhard Spingler, Roger Alberto
-
Chiral Quaternary Ammonium Salt-Catalyzed Enantioselective Addition Reactions of Hydantoins Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-28 Katharina Röser, Lucas Prameshuber, Sajid Jahangir, Sharath Chandra Mallojjala, Jennifer S. Hirschi, Mario Waser
-
Radicals and Carbohydrates: A Grand Alliance Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-21 Béatrice Quiclet-Sire, Samir Z. Zard
-
Playing with Protic Additives to Improve the Outcome of Rhodium-Catalyzed Hydroarylation of Fullerene C60 with Arylboronic Acids Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-15 Merve Ergun Dönmez, Måns Eriksson, Gustav Hulu, Michael Nordström, Helena Grennberg
-
Strategies for Direct, Transition Metal-Free Addition of Nitrogen Synthons to Alkenes Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-15 Brett N. Hemric, Thalia A. Garcia, Adriana E. Barni
-
Hydroalkylation of 1,1-Diarylalkenes Mediated by Magnesium Hydride in Ethereal Solvents Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-14 Nattawadee Chaisan, Eugene Yew Kun Tan, Shunsuke Chiba
-
Twofold Alkenylation of Thiophenes with N-Vinylcarbazole via Iron-Catalyzed Regioselective C−H/C−H Coupling Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-12 Takahiro Doba, Rui Shang, Eiichi Nakamura
-
Alternative Routes to 4,6-O-Benzylidene β-Thioglycosides Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-11 Daniela Imperio, Filippo Valloni, Luigi Panza
-
A Special Issue Dedicated to Professor Andrea Vasella Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-06 Karin Briner, Werngard Czechtizky, Thomas Storz, Bruno Bernet, Roland Bürli, Alexander Ernst
-
Thirty-Three Years Member of the Group Vasella by Bruno Bernet Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-06 Bruno Bernet
-
Steric Bulk-Dependent Photoresponse of Sulfonamide Azobenzene Ligand in Arene Ruthenium(II) Complexes Helv. Chimica Acta (IF 1.8) Pub Date : 2023-12-01 Jonathan Long, Pascal Retailleau, Juan Xie, Nicolas Bogliotti
-
Probing the Nature of Surface Hydrides by Deuterium Quadrupolar Parameters: A Case Study on Silica-Supported Zirconium Hydrides Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-23 Scott R. Docherty, Philipp Schärz, Domenico Gioffrè, Alexander V. Yakimov, Christophe Copéret
-
HFIP Mediated Synthesis of C4-Aryl-2-quinolones through Serial Oxidation Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-21 Seung Hoon Lee, Minseok Kang, Hyung Min Chi
-
Development of Photoredox-Assisted Direct α-Alkylation Reactions of Ketones with Arylalkenes Using a Catalytic Amount of LiOtBu as a Brønsted Base Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-20 Tsubasa Hirata, Tomoya Hisada, Yoshihiro Ogasawara, Shū Kobayashi, Yasuhiro Yamashita
-
Scalable Preparation of 1-Aminoethyl Oxindoles From Simple Benzaldehydes Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-16 Cédric Bürki, Stefan Diethelm, Fabio D'Aiuto, Marco Künzli, Gaëlle Mathieu, Christine Schmitt
-
Improved Synthesis of Chiral 1,4,7-Triazacyclononane Derivatives and Their Application in Ni-Catalyzed Csp3−Csp3 Kumada Cross-Coupling Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-15 Chi-Herng Hu, Ju Byeong Chae, Liviu M. Mirica
-
Synthesis and Olfactory Properties of Lower-Ring Homologues of the Linear Alicyclic Musk Romandolide Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-14 Vladimír Dacho, Artem Nikipelov, Michaela Tóthová, Philip Kraft, Peter Szolcsányi
-
Keap It in the Family: How to Fish out New Paradigms in Keap1-Mediated Cell Signaling Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-13 Marcus J. C. Long, Kuan-Ting Huang, Yimon Aye
-
Tailoring the Hybridization Density of DNA Biosensors through Tunable Surface Functionalization Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-13 Perrine Robin, Lucas Mayoraz, Pauline Skigin, Mounir Mensi, Sandrine Gerber-Lemaire
-
A Practical and Scalable Non-Photonic Decarboxylative C−N Coupling of Bicyclo[1.1.1]Pentane Carboxylate by Leveraging High Throughput Experimentation Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-04 Nathan J. Gesmundo, Lei Shi, Russell C. Smith
-
Scalable Preparation of 1-Aminoethyl Substituted Chromanes Helv. Chimica Acta (IF 1.8) Pub Date : 2023-11-03 Stefan Diethelm, Gunther Schmidt, Thierry Sifferlen, Amandine Boller, Laurent Cornu, Christine Schmitt
-
Prediction of Reaction Performance by Machine Learning Using Streamlined Features: NMR Chemical Shifts as Familiar Descriptors Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-27 Su-min Song, Ha Eun Kim, Hyun Woo Kim, Won-jin Chung
-
-
A Multiplex GPCR-Mediated Peptide Tagging System for a Growing Yeast Synthetic Biology Toolbox Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-22 Joseph Matragrano, Virginia W. Cornish, Sonja Billerbeck
-
Dynemicin A Derivatives as Potential Cancer Chemotherapeutics by Mutasynthesis Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-21 Paramita Pal, Jamie R. Alley, Douglas R. Cohen, Craig A. Townsend
-
Kilogram-Scale Synthesis of 4-Chloro-6-(6-methoxypyridin- 3-yl)pyrimidine through a Suzuki–Miyaura Cross-Coupling Using Micellar Catalysis Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-18 Nicholas A. Isley, Fabrice Gallou
-
Optimizing Phosphate Couplings for Dolichyl Diphosphochitobiose to Enable Protein N-Glycosylation Studies Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-13 Matheus A. Meirelles, Jean-Louis Reymond
-
Development of a 2nd Generation Process for 3-Ethyl-4-Hydroxy-5-Methylbenzonitrile – A Key Building Block of S1P1 Receptor Modulator Cenerimod – through a Non-Classical Nitrile Formation Using Hydroxylamine-O-sulfonic Acid (HOSA) Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-11 Gabriel Schäfer, Tony Fleischer
-
Introduction for the Special Collection of Papers in the Honor of Robert Deschenaux. Helv. Chimica Acta (IF 1.8) Pub Date : 2023-10-04 Jean-François Nierengarten, Jean-Marie Lehn