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Spatiotemporal orchestration of macrophage activation trajectories by Vγ4 T cells during skin wound healing iScience (IF 5.8) Pub Date : 2024-03-21 Wengang Hu, Xiaorong Zhang, Zhongyang Liu, Jiacai Yang, Hao Sheng, Zhihui Liu, Cheng Chen, Ruoyu Shang, Yunxia Chen, Yifei Lu, Xiaohong Hu, Yong Huang, Wenjing Yin, Xin Cai, Dejiang Fan, Lingfeng Yan, Jianlei Hao, Gaoxing Luo, Weifeng He
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Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells iScience (IF 5.8) Pub Date : 2024-03-20 Carlo Zimarino, William Moody, Sarah E. Davidson, Hafsa Munir, Jacqueline D. Shields
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Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects iScience (IF 5.8) Pub Date : 2024-03-20 Huiting Hu, Yuqian Cai, Yuanfang Shi, Shengyu Zhang, Xiaoxuan Yu, Tonghui Ma, Shanting Liao
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Machine learning approaches for practical predicting outpatient near-future AECOPD based on nationwide electronic medical records iScience (IF 5.8) Pub Date : 2024-03-20 Kuang-Ming Liao, Kuo-Chen Cheng, Mei-I Sung, Yu-Ting Shen, Chong-Chi Chiu, Chung-Feng Liu, Shian-Chin Ko
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TRPA5 encodes a thermosensitive ankyrin ion channel receptor in a triatomine insect iScience (IF 5.8) Pub Date : 2024-03-20 Marjorie A. Liénard, David Baez-Nieto, Cheng-Chia Tsai, Wendy A. Valencia-Montoya, Balder Werin, Urban Johanson, Jean-Marc Lassance, Jen Q. Pan, Nanfang Yu, Naomi E. Pierce
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Islet-resident macrophage-derived miR-155 promotes β cell decompensation via targeting PDX1 iScience (IF 5.8) Pub Date : 2024-03-20 Yan Zhang, Rong Cong, Tingting Lv, Kerong Liu, Xiaoai Chang, Yating Li, Xiao Han, Yunxia Zhu
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Rab27a promotes degradation of West Nile virus E protein in the lysosome iScience (IF 5.8) Pub Date : 2024-03-19 Shintaro Kobayashi, Seira Kawai, Yukine Fukuda, Haruto Eguchi, Keisuke Maezono, Passawat Thammahakin, Hirofumi Sawa, Hiroaki Kariwa
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Multiomic analysis of early epileptogenesis in mice reveals phosphorylation and dephosphorylation-directed growth and synaptic weakening iScience (IF 5.8) Pub Date : 2024-03-19 Mariella Hurtado Silva, Ashley J. van Waardenberg, Aya Mostafa, Susanne Schoch, Dirk Dietrich, Mark E. Graham
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Long COVID across SARS-CoV-2 variants, lineages, and sublineages iScience (IF 5.8) Pub Date : 2024-03-19 Sergio Padilla, Christian Ledesma, Javier García-Abellán, José Alberto García, Marta Fernández-González, Alba de la Rica, Antonio Galiana, Félix Gutiérrez, Mar Masiá
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The frontier of tungsten oxide nanostructures in electronic applications iScience (IF 5.8) Pub Date : 2024-03-19 Siqi Zhou, Zanhe Yang, Xiangyu Feng, Jiaxin Zuo, Nannan Wang, Kunyapat Thummavichai, Yanqiu Zhu
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ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-catenin/PD-L1 axis iScience (IF 5.8) Pub Date : 2024-03-19 Rilin Deng, Renyun Tian, Xinran Li, Yan Xu, Yongqi Li, Xintao Wang, Huiyi Li, Luoling Wang, Biaoming Xu, Di Yang, Songqing Tang, Binbin Xue, Chaohui Zuo, Haizhen Zhu
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Infection induced inflammation impairs wound healing through IL-1β signaling iScience (IF 5.8) Pub Date : 2024-03-19 Simone Shen, Veronika Miskolci, Colin N. Dewey, John-Demian Sauer, Anna Huttenlocher
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Bacteria associated with the in hospite Symbiodiniaceae’s phycosphere iScience (IF 5.8) Pub Date : 2024-03-19 Lilian Jorge Hill, Camila Simões Martins de Aguiar Messias, Caren Leite Spindola Vilela, Alessandro Nascimento Garritano, Helena Dias Muller Villela, Flavia Lima do Carmo, Torsten Thomas, Raquel Silva Peixoto
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Bursts of vagus nerve stimulation paired with auditory rehabilitation fail to improve speech sound perception in rats with hearing loss iScience (IF 5.8) Pub Date : 2024-03-19 Alan M. Carroll, Jonathan R. Riley, Michael S. Borland, Tanya T. Danaphongse, Seth A. Hays, Michael P. Kilgard, Crystal T. Engineer
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The molecular signature of BCR::ABLP210 and BCR::ABLT315I in a Drosophila melanogaster chronic myeloid leukemia model iScience (IF 5.8) Pub Date : 2024-03-18 Amro Baassiri, Ali Ghais, Abdallah Kurdi, Elias Rahal, Rihab Nasr, Margret Shirinian
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A dual role of the conserved PEX19 helix in safeguarding peroxisomal membrane proteins iScience (IF 5.8) Pub Date : 2024-03-18 Jeonghyun Oh, Do Kyung Kim, Seung Hae Ahn, Ho Min Kim, Hyunju Cho
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Reduced chondroitin sulfate content prevents diabetic neuropathy through transforming growth factor-β signaling suppression iScience (IF 5.8) Pub Date : 2024-03-18 Hajime Ishiguro, Takashi Ushiki, Atsuko Honda, Yasuhiro Yoshimatsu, Riuko Ohashi, Shujiro Okuda, Asami Kawasaki, Kaori Cho, Suguru Tamura, Tatsuya Suwabe, Takayuki Katagiri, Yiwei Ling, Atsuhiko Iijima, Tadahisa Mikami, Hiroshi Kitagawa, Akiyoshi Uemura, Kazunori Sango, Masayoshi Masuko, Michihiro Igarashi, Hirohito Sone
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Neurophysiological effective network connectivity supports a threshold-dependent management of dynamic working memory gating iScience (IF 5.8) Pub Date : 2024-03-18 Julia Elmers, Shijing Yu, Nasibeh Talebi, Astrid Prochnow, Christian Beste
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Linel2D-Net: a deep learning approach to solving 2D linear elastic boundary value problems on image domains iScience (IF 5.8) Pub Date : 2024-03-18 Anto Nivin Maria Antony, Narendra Narisetti, Evgeny Gladilin
Efficient solution of physical boundary value problems (BVPs) remains a challenging task demanded in many applications. Conventional numerical methods require time-consuming domain discretization and solving techniques that have limited throughput capabilities. Here, we present an efficient data-driven DNN approach to non-iterative solving arbitrary 2D linear elastic BVPs. Our results show that a U-Net
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Dynamics of land cover changes and carbon emissions driven by large dams in China iScience (IF 5.8) Pub Date : 2024-03-18 Liuyue He, Nishan Bhattarai, Yadu Pokhrel, Nan Jia, Peng Zhu, Guanqiong Ye, Zhenci Xu, Shaohua Wu, Zhongbin B. Li
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Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS iScience (IF 5.8) Pub Date : 2024-03-18 Jiang-Hui Meng, Yong-Biao Huang, Jin Long, Qiu-Chen Cai, Xin Qiao, Qiong-Li Zhang, Li-Dan Zhang, Xiang Yan, Rui Jing, Xing-Shan Liu, Sai-Jun Zhou, Yong-Sheng Yuan, Yin-Chen Ma, Li-Xiang Zhou, Nan-Nan Peng, Xing-Cheng Li, Cheng-Hui Cai, Hong-Mei Tang, André F. Martins, Jean X. Jiang, Kai-Jun Luo
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RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair iScience (IF 5.8) Pub Date : 2024-03-16 Mi Young Son, Ondrej Belan, Mario Spirek, Jakub Cibulka, Fedor Nikulenkov, You Young Kim, Sunyoung Hwang, Kyungjae Myung, Cristina Montagna, Tae Moon Kim, Lumir Krejci, Paul Hasty
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Cystine-cored diphenylalanine appended peptide-based self-assembled fluorescent nanostructures direct redox-responsive drug delivery iScience (IF 5.8) Pub Date : 2024-03-16 Suman Nayak, Kiran Das, Subramaniyam Sivagnanam, Shyamvarnan Baskar, Adele Stewart, Dinesh Kumar, Biswanath Maity, Priyadip Das
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TDP-43 deficiency in suprachiasmatic nucleus perturbs rhythmicity of neuroactivity in prefrontal cortex iScience (IF 5.8) Pub Date : 2024-03-16 Hongxia Zhang, Chen Chen, Eric Erquan Zhang, Xiaotian Huang
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Spatio-temporal variations of methane fluxes in sediments of a deep stratified temperate lake iScience (IF 5.8) Pub Date : 2024-03-16 Manchun Kang, Liu Liu, Hans-Peter Grossart
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Secondary metabolites in host pears defense against two fruit borers and cytochrome-P450-mediated counter-defense iScience (IF 5.8) Pub Date : 2024-03-16 Shi-Pan Zhang, Bing Bai, Gao-Man Chen, Ya-Qi Wang, Chao Hu, Xu-Fei Liu, Ping Gao, Yu-Ting Li, Nan-Xia Fu, Xue-Qing Yang
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Anoxia-induced hippocampal LTP is regeneratively produced by glutamate and nitric oxide from the neuro-glial-endothelial axis iScience (IF 5.8) Pub Date : 2024-03-16 Han-Ying Wang, Hiroshi Takagi, Patrick N. Stoney, Anai Echeverria, Bernd Kuhn, Kuei-Sen Hsu, Tomoyuki Takahashi
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Adsorption and desorption behavior of Zn2+ in a flow-through electrosorption reactor iScience (IF 5.8) Pub Date : 2024-03-16 Yusen Dong, Manci Jiang, Jing Zhao, Fei Zhang, Shaohua Ma, Yang Zhang
As heavy metal industrial wastewater increases in volume and complexity, we need more efficient, cheaper, and renewable technologies to curb its environmental impact. Compared to advection electrosorption, through-flow electrosorption is a hotspot technique that makes more efficient use of the adsorption capacity of activated carbon fiber mats. A cascade flow-through electrosorption assembly based
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Oxidative stress is intrinsic to staphylococcal adaptation to fatty acid synthesis antibiotics iScience (IF 5.8) Pub Date : 2024-03-16 Paprapach Wongdontree, Aaron Millan-Oropeza, Jennifer Upfold, Jean-Pierre Lavergne, David Halpern, Clara Lambert, Adeline Page, Gérald Kénanian, Christophe Grangeasse, Céline Henry, Agnès Fouet, Karine Gloux, Jamila Anba-Mondoloni, Alexandra Gruss
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Penetrating the ultra-tough yeast cell wall with finite element analysis model-aided design of microtools iScience (IF 5.8) Pub Date : 2024-03-16 Yanfei Zhang, Wende He, Li Wang, Weiguang Su, Hao Chen, Anqing Li, Jun Chen
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CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo iScience (IF 5.8) Pub Date : 2024-03-16 Yan Liu, Yanyan Yang, Min Li, Xiuxiu Fu, Xiangqin He, Xiaoxin Li, Jae Youl Cho, Pei-feng Li, Tao Yu
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Predicting left ventricular remodeling post-MI through coronary physiological measurements based on computational fluid dynamics iScience (IF 5.8) Pub Date : 2024-03-15 Wen Zheng, Qian Guo, Ruifeng Guo, Yingying Guo, Hui Wang, Lei Xu, Yunlong Huo, Hui Ai, Bin Que, Xiao Wang, Shaoping Nie
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The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl− extrusion iScience (IF 5.8) Pub Date : 2024-03-15 Noell Cho, Georgina Kontou, Joshua L. Smalley, Christopher Bope, Jacob Dengler, Kristopher Montrose, Tarek Z. Deeb, Nicholas J. Brandon, Tadashi Yamamoto, Paul A. Davies, Georgios Giamas, Stephen J. Moss
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A mechanism linking ferroptosis and ferritinophagy in melatonin-related improvement of diabetic brain injury iScience (IF 5.8) Pub Date : 2024-03-15 Jiaojiao Yu, Yu Zhang, Qin Zhu, Zhengrui Ren, Mengting Wang, Sasa Kong, Hongbo Lv, Tao Xu, Zhaoyu Xie, Han Meng, Jun Han, Hui Che
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The activation of LBH-CRYAB signaling promotes cardiac protection against ischemia-reperfusion injury by inhibiting apoptosis and ferroptosis iScience (IF 5.8) Pub Date : 2024-03-15 Anbiao Wu, Chongbin Zhong, Xudong Song, Wen Yuan, Mintian Tang, Tao Shu, Houda Huang, Pingzhen Yang, Qicai Liu
Myocardial ischemia-reperfusion (I/R) injury stands out among cardiovascular diseases, and current treatments are considered unsatisfactory. For cardiomyocytes (CMs) in ischemic tissues, the upregulation of Limb-bud and Heart (LBH) and αB-crystallin (CRYAB) and their subsequent downregulation in the context of cardiac fibrosis have been verified in our previous research. Here, we focused on the effects
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Inference of drug off-target effects on cellular signaling using interactome-based deep learning iScience (IF 5.8) Pub Date : 2024-03-14 Nikolaos Meimetis, Douglas A. Lauffenburger, Avlant Nilsson
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Epidemiology of 369 diseases and injuries attributable to 84 risk factors: 1990–2019 with 2040 projection iScience (IF 5.8) Pub Date : 2024-03-14 Kexin Zhang, Chengxia Kan, Jian Chen, Junfeng Shi, Yanhui Ma, Xiaoli Wang, Xuan Li, Weiqin Cai, Ruiyan Pan, Jingwen Zhang, Zhentao Guo, Fang Han, Ningning Hou, Xiaodong Sun
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Restoring vision in adult amblyopia by enhancing plasticity through deletion of the transcriptional repressor REST iScience (IF 5.8) Pub Date : 2024-03-14 Dmytro Shmal, Giulia Mantero, Thomas Floss, Fabio Benfenati, José Fernando Maya-Vetencourt
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Tumor-derived extracellular vesicles as a biomarker for breast cancer diagnosis and metastasis monitoring iScience (IF 5.8) Pub Date : 2024-03-14 Feng Xu, Ke Wang, Chengjun Zhu, Lingling Fan, Ye Zhu, Jacqueline F. Wang, Xintong Li, Yiqiu Liu, Yuhan Zhao, Chuandong Zhu, Wenwen Zhang, Fang Yang, Jian Xu, Zhe Li, Xiaoxiang Guan
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Melanin-like nanoparticles alleviate ischemia-reperfusion injury in the kidney by scavenging reactive oxygen species and suppressing ferroptosis iScience (IF 5.8) Pub Date : 2024-03-14 Wenxiang Feng, Nan Zhu, Yubin Xia, Zehai Huang, Jianmin Hu, Zefeng Guo, Yuzhuz Li, Song Zhou, Yongguang Liu, Ding Liu
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Integrative analysis of single-nucleus RNA-seq and bulk RNA-seq reveals germline cells development dynamics and niches in the Pacific oyster gonad iScience (IF 5.8) Pub Date : 2024-03-14 Huihui Wang, Hong Yu, Qi Li
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Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice iScience (IF 5.8) Pub Date : 2024-03-14 Yong Ge, Changjun Yang, Mojgan Zadeh, Shane M. Sprague, Yang-Ding Lin, Heetanshi Sanjay Jain, Brenden Fitzgerald Determann II, William H. Roth, Juan Pablo Palavicini, Jonathan Larochelle, Eduardo Candelario-Jalil, Mansour Mohamadzadeh
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Applying machine learning for multi-individual Raman spectroscopic data to identify different stages of proliferating human hepatocytes iScience (IF 5.8) Pub Date : 2024-03-13 Bihan Shen, Chen Ma, Lili Tang, Zhitao Wu, Zhaoliang Peng, Guoyu Pan, Hong Li
Cell therapy using proliferating human hepatocytes (ProliHHs) is an effective treatment approach for advanced liver diseases. However, rapid and accurate identification of high-quality ProliHHs from different donors is challenging due to individual heterogeneity. Here, we developed a machine learning framework to integrate single-cell Raman spectroscopy from multiple donors and identify different stages
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Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity iScience (IF 5.8) Pub Date : 2024-03-12 Zi-Ling Qu, Xiu-Ying Gong, Li-li An, Hao-Yu Sun, Wen-Hao Guo, Hong-Yu Luan, Meng-Yao Wu, Cheng Dan, Jian-Fang Gui, Yi-Bing Zhang
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Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation iScience (IF 5.8) Pub Date : 2024-03-12 Nathalie A. Reilly, Friederike Sonnet, Koen F. Dekkers, Joanneke C. Kwekkeboom, Lucy Sinke, Stan Hilt, Hayat M. Suleiman, Marten A. Hoeksema, Hailiang Mei, Erik W. van Zwet, Bart Everts, Andreea Ioan-Facsinay, J. Wouter Jukema, Bastiaan T. Heijmans
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Caenorhabditis elegans neuropeptide NLP-27 enhances neurodegeneration and paralysis in an opioid-like manner during fungal infection iScience (IF 5.8) Pub Date : 2024-03-12 Maria Pop, Anna-Lena Klemke, Lena Seidler, Nicole Wernet, Pietrina Loredana Steudel, Vanessa Baust, Elke Wohlmann, Reinhard Fischer
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Sexual dimorphism of circadian liver transcriptome iScience (IF 5.8) Pub Date : 2024-03-12 Artem A. Astafev, Volha Mezhnina, Allan Poe, Peng Jiang, Roman V. Kondratov
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A real-time energy management strategy for fuel cell vehicle based on Pontryagin’s minimum principle iScience (IF 5.8) Pub Date : 2024-03-12 Rui Quan, Haifeng Guo, Xuerong Li, Jian Zhang, Yufang Chang
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Precise regulation of phosphorus in nitrogen-coordinated porous carbon spheres for tunable CO2 electroreduction to syngas iScience (IF 5.8) Pub Date : 2024-03-12 Qi Xu, Wentao Wang, Yangyang Zhang, Huanhuan Liu, Xiaowen Wang, Suyuan Zeng, Genqiang Zhang
The production of high-demand syngas with tunable ratios by CO electroreduction has attracted considerable research interest. However, it is challenging to balance the evolutionary performance of H and CO with wide H/CO ratios, while maintaining high efficiency. Herein, nitrogen-coordinated hierarchical porous carbon spheres with varying phosphorus content (PNC-T) are assembled to regulate syngas production
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High affinity mAb infusion can enhance maximum affinity maturation during HIV Env immunization iScience (IF 5.8) Pub Date : 2024-03-11 Peter Thomas, Chloe Rees-Spear, Sarah Griffith, Luke Muir, Emma Touizer, Raiees Andrabi, Richard Priest, Jennifer Percival-Alwyn, Darryl Hayward, Amanda Buxton, William Traylen, Benny Chain, Trevor Wattam, Irene Sanjuan Nandin, Laura E. McCoy
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Bacopa monnieri phytochemicals regulate fibroblast cell migration via modulation of focal adhesions iScience (IF 5.8) Pub Date : 2024-03-11 Ravindra K. Zirmire, Dyuti Saha, Rakesh Dey, Habibu Tanimu, Rania Zaarour, Deborah Bird, Prakash Cherian, Isha Rana, Nita Roy, Aryasekhar Sanyal, Namita Misra, Colin Jamora
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The discovery of Candidatus Nanopusillus phoceensis sheds light on the diversity of the microbiota nanoarchaea iScience (IF 5.8) Pub Date : 2024-03-11 Yasmine Hassani, Gerard Aboudharam, Michel Drancourt, Ghiles Grine
To further assess the spectrum of nanoarchaea in human microbiota, we prospectively searched for nanoarchaea in 110 leftover stool specimens, using the complementary approaches of PCR-sequencing screening, fluorescent hybridization, scanning electron microscopy and metagenomics. These investigations yielded a nanoarchaea, Nanopusillus phoceensis sp. nov., detected in stool samples by specific PCR-based
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Defects of renal tubular homeostasis and cystogenesis in the Pkhd1 knockout iScience (IF 5.8) Pub Date : 2024-03-11 Julia C. Fox, Susanne T. Hahnenstein, Fatima Hassan, Andrea Grund, Dieter Haffner, Wolfgang H. Ziegler
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Underwater smart glasses: A visual-tactile fusion hazard detection system iScience (IF 5.8) Pub Date : 2024-03-11 Zhongze Ma, Chenjie Zhang, Pengcheng Jiao
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Prior knowledge biases the visual memory of body postures iScience (IF 5.8) Pub Date : 2024-03-11 Qiu Han, Marco Gandolfo, Marius V. Peelen
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Hybridized nanozymes for anti-osteosarcoma therapy via the Fenton reaction iScience (IF 5.8) Pub Date : 2024-03-11 Junjie Zheng, Lin Huang, Jinying Wang, Shiqiang Zhuo, Gaofeng Huang
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Clonal hematopoiesis is associated with cardiovascular events in patients with stable coronary artery disease iScience (IF 5.8) Pub Date : 2024-03-11 Mihaela I. Dregoesc, Helin Tercan, Adrian B. Țigu, Siroon Bekkering, Leo AB. Joosten, Mihai G. Netea, Rosanne C. van Deuren, Alexander Hoischen, Niels P. Riksen, Adrian C. Iancu
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T cells with increased responsiveness cause obesity in mice without diet intervention iScience (IF 5.8) Pub Date : 2024-03-11 Ida Gregersen, Xiang Y. Kong, Sander Kooijman, Håvard Foyn, Helene Grannes, Maria B. Olsen, Anna M. Lone, Kuan Yang, Ana Quiles-Jiménez, Marianne Tran, Jonas Øgaard, Filip M. Segers, Azita Rashidi, Ellen Lund Sagen, Knut H. Lauritzen, Amanda C.M. Pronk, Jan Freark de Boer, Kirsten B. Holven, Espen Melum, Pål Aukrust, Kjetil Taskén, Sverre Holm, Patrick C.N. Rensen, Tuva B. Dahl, Bente Halvorsen
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Creatine and low-dose lithium supplementation separately alter energy expenditure, body mass, and adipose metabolism for the promotion of thermogenesis iScience (IF 5.8) Pub Date : 2024-03-11 M.S. Finch, G.L. Gardner, J.L. Braun, M.S. Geromella, J. Murphy, K. Colonna, R. Dhaliwal, A. Retta, A. Mohammad, J.A. Stuart, P.J. LeBlanc, V.A. Fajardo, B.D. Roy, R.E.K. MacPherson
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Oleuropein activates autophagy to circumvent anti-plasmodial defense iScience (IF 5.8) Pub Date : 2024-03-11 Praveen Sharma, Nikunj Tandel, Rajinder Kumar, Sushmita Negi, Prakriti Sharma, Sonia Devi, Kanika Saxena, Neil Roy Chaudhary, Sheetal Saini, Reetesh Kumar, Bharat Singh Chandel, Puran S. Sijwali, Rajeev K. Tyagi