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Engineering Photothermal Catalytic CO2 Nanoreactor for Osteomyelitis Treatment by In Situ CO Generation Adv. Sci. (IF 15.1) Pub Date : 2024-04-23 Fan Zhuang, Luxia Jing, Huijing Xiang, Cuixian Li, Beilei Lu, Lixia Yan, Jingjing Wang, Yu Chen, Beijian Huang
Photocatalytic carbon dioxide (CO2) reduction is an effective method for in vivo carbon monoxide (CO) generation for antibacterial use. However, the available strategies mainly focus on utilizing visible‐light‐responsive photocatalysts to achieve CO generation. The limited penetration capability of visible light hinders CO generation in deep‐seated tissues. Herein, a photothermal CO2 catalyst (abbreviated
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Regulating the Electron Distribution of Metal‐Oxygen for Enhanced Oxygen Stability in Li‐rich Layered Cathodes Adv. Sci. (IF 15.1) Pub Date : 2024-04-23 Zijia Yin, Jun Zhao, Dong Luo, Yi‐Ying Chin, Chien‐Te Chen, Huaican Chen, Wen Yin, Yu Tang, Tingting Yang, Jincan Ren, Tianyi Li, Kamila M. Wiaderek, Qingyu Kong, Jun Fan, He Zhu, Yang Ren, Qi Liu
Li‐rich Mn‐based layered oxides (LLO) hold great promise as cathode materials for lithium‐ion batteries (LIBs) due to their unique oxygen redox (OR) chemistry, which enables additional capacity. However, the LLOs face challenges related to the instability of their OR process due to the weak transition metal (TM)‐oxygen bond, leading to oxygen loss and irreversible phase transition that results in severe
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Universal Approach to Direct Spatiotemporal Dynamic In Situ Optical Visualization of On‐Catalyst Water Splitting Electrochemical Processes Adv. Sci. (IF 15.1) Pub Date : 2024-04-23 Gaurav Bahuguna, Fernando Patolsky
Electrochemical reactions are the unrivaled backbone of next‐generation energy storage, energy conversion, and healthcare devices. However, the real‐time visualization of electrochemical reactions remains the bottleneck for fully exploiting their intrinsic potential. Herein, for the first time, a universal approach to direct spatiotemporal‐dynamic in situ optical visualization of pH‐based as well as
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T‐bet Regulates Ion Channels and Transporters and Induces Apoptosis in Intestinal Epithelial Cells Adv. Sci. (IF 15.1) Pub Date : 2024-04-23 Lang Chen, Hongwei Yi, Qingtian Li, Tianhao Duan, Xin Liu, Linfeng Li, Helen Y. Wang, Changsheng Xing, Rong‐Fu Wang
T‐bet, encoded by TBX21, is extensively expressed across various immune cell types, and orchestrates critical functions in their development, survival, and physiological activities. However, the role of T‐bet in non‐immune compartments, notably the epithelial cells, remains obscure. Herein, a Tet‐O‐T‐bet transgenic mouse strain is generated for doxycycline‐inducible T‐bet expression in adult animals
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Catalytic Asymmetric Construction of α,α‐Diaryl Aldehydes via Oxo‐Hydroarylation of Terminal Alkynes Adv. Sci. (IF 15.1) Pub Date : 2024-04-23 Xueting Zhou, Qingqin Huang, Jiami Guo, Lei Dai, Yixin Lu
Chiral aldehydes containing a tertiary stereogenic center are versatile building blocks in organic chemistry. In particular, such structural motifs bearing an α,α‐diaryl moiety are very challenging scaffolds and their efficient asymmetric synthesis is not reported. In this work, a phosphoric acid‐catalyzed enantioselective synthesis of α,α‐diaryl aldehydes from simple terminal alkynes is presented
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Dual‐Responsive MXene‐Functionalized Wool Yarn Artificial Muscles Adv. Sci. (IF 15.1) Pub Date : 2024-04-23 Liuxiang Zhan, Shaohua Chen, Yangyang Xin, Jian Lv, Hongbo Fu, Dace Gao, Feng Jiang, Xinran Zhou, Ni Wang, Pooi See Lee
Fiber‐based artificial muscles are promising for smart textiles capable of sensing, interacting, and adapting to environmental stimuli. However, the application of current artificial muscle‐based textiles in wearable and engineering fields has largely remained a constraint due to the limited deformation, restrictive stimulation, and uncomfortable. Here, dual‐responsive yarn muscles with high contractile
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Gas‐Solid Phase Reaction Derived Silver Bismuth Iodide Rudorffite: Structural Insight and Exploring Photocatalytic Potential of CO2 Reduction Adv. Sci. (IF 15.1) Pub Date : 2024-04-23 Jia‐Mao Chang, Ting‐Han Lin, Kai‐Chi Hsiao, Kuo‐Ping Chiang, Yin‐Hsuan Chang, Ming‐Chung Wu
Photocatalytic reduction of CO2 is a promising strategy to mitigate the effects of global warming by converting CO2 into valuable energy‐dense products. Silver bismuth iodide (SBI) is an attractive material owing to its tunable bandgap and favorable band‐edge positions for efficient CO2 photoreduction. In this study, SBI materials, including AgBi2I7, AgBiI4, Ag2BiI5, and Ag3BiI6 are first synthesized
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Facile Lithium Densification Kinetics by Hyperporous/Hybrid Conductor for High‐Energy‐Density Lithium Metal Batteries Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Dong‐Yeob Han, Saehun Kim, Seoha Nam, Gayoung Lee, Hongyeul Bae, Jin Hong Kim, Nam‐Soon Choi, Gyujin Song, Soojin Park
Lithium metal anode (LMA) emerges as a promising candidate for lithium (Li)‐based battery chemistries with high‐energy‐density. However, inhomogeneous charge distribution from the unbalanced ion/electron transport causes dendritic Li deposition, leading to “dead Li” and parasitic reactions, particularly at high Li utilization ratios (low negative/positive ratios in full cells). Herein, an innovative
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Light‐Intensity Switching of Graphene/WSe2 Synaptic Devices Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Hongyu Tang, Tarique Anwar, Min Seok Jang, Giulia Tagliabue
2D van der Waals heterojunctions (vdWH) have emerged as an attractive platform for the realization of optoelectronic synaptic devices, which are critical for energy‐efficient computing systems. Photogating induced by charge traps at the interfaces indeed results in ultrahigh responsivity and tunable photoconductance. Yet, optical potentiation and depression remain mostly modulated by gate bias, requiring
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Hemodynamic Bedside Monitoring Instrument with Pressure and Optical Sensors: Validation and Modality Comparison Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Matti Kaisti, Tuukka Panula, Jukka‐Pekka Sirkiä, Mikko Pänkäälä, Tero Koivisto, Teemu Niiranen, Ilkka Kantola
Results from two independent clinical validation studies for measuring hemodynamics at the patient's bedside using a compact finger probe are reported. Technology comprises a barometric pressure sensor, and in one implementation, additionally, an optical sensor for photoplethysmography (PPG) is developed, which can be used to measure blood pressure and analyze rhythm, including the continuous detection
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Tartronic Acid as a Potential Inhibitor of Pathological Calcium Oxalate Crystallization Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Yuan Su, Si Li, Xin Li, Jing‐Ying Zhou, Vraj P. Chauhan, Meng Li, Ya‐Hui Su, Chun‐Mei Liu, Yi‐Fei Ren, Wu Yin, Jeffrey D. Rimer, Ting Cai
Kidney stones are a pervasive disease with notoriously high recurrence rates that require more effective treatment strategies. Herein, tartronic acid is introduced as an efficient inhibitor of calcium oxalate monohydrate (COM) crystallization, which is the most prevalent constituent of human kidney stones. A combination of in situ experimental techniques and simulations are employed to compare the
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Antimicrobial and Antiviral Nanofibers Halt Co‐Infection Spread via Nuclease‐Mimicry and Photocatalysis Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Jieran Yao, Zhenhong Luo, Jiaying Lin, Na Meng, Jiangna Guo, Hui Xu, Rongwei Shi, Linhui Zhao, Jiateng Zhou, Feng Yan, Bin Wang, Hailei Mao
The escalating spread of drug‐resistant bacteria and viruses is a grave concern for global health. Nucleic acids dominate the drug‐resistance and transmission of pathogenic microbes. Here, imidazolium‐type poly(ionic liquid)/porphyrin (PIL‐P) based electrospun nanofibrous membrane and its cerium (IV) ion complex (PIL‐P‐Ce) are developed. The obtained PIL‐P‐Ce membrane exhibits high and stable efficiency
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Tuning Thermal Conductivity of Hybrid Perovskites through Halide Alloying Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Guang Wang, Hongzhao Fan, Zhongwei Chen, Yufei Gao, Zuankai Wang, Zhigang Li, Haipeng Lu, Yanguang Zhou
Tuning the thermal transport properties of hybrid halide perovskites is critical for their applications in optoelectronics, thermoelectrics, and photovoltaics. Here, an effective strategy is demonstrated to modulate the thermal transport property of hybrid perovskites by halide alloying. A highly tunable thermal conductivity of mixed‐halide hybrid perovskites is achieved due to halide‐alloying and
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HOXA‐AS2 Epigenetically Inhibits HBV Transcription by Recruiting the MTA1‐HDAC1/2 Deacetylase Complex to cccDNA Minichromosome Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 YiPing Qin, JiHua Ren, HaiBo Yu, Xin He, ShengTao Cheng, WeiXian Chen, Zhen Yang, FengMing Sun, ChunDuo Wang, SiYu Yuan, Peng Chen, DaiQing Wu, Fang Ren, AiLong Huang, Juan Chen
Persistent transcription of HBV covalently closed circular DNA (cccDNA) is critical for chronic HBV infection. Silencing cccDNA transcription through epigenetic mechanisms offers an effective strategy to control HBV. Long non‐coding RNAs (lncRNAs), as important epigenetic regulators, have an unclear role in cccDNA transcription regulation. In this study, lncRNA sequencing (lncRNA seq) is conducted
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2D Halide Perovskites for High‐Performance Resistive Switching Memory and Artificial Synapse Applications Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Bixin Li, Fei Xia, Bin Du, Shiyang Zhang, Lan Xu, Qiong Su, Dingke Zhang, Junliang Yang
Metal halide perovskites (MHPs) are considered as promising candidates in the application of nonvolatile high‐density, low‐cost resistive switching (RS) memories and artificial synapses, resulting from their excellent electronic and optoelectronic properties including large light absorption coefficient, fast ion migration, long carrier diffusion length, low trap density, high defect tolerance. Among
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A Scalable and Robust Personal Health Management Textile with Multiple Desired Thermal Functions and Electromagnetic Shielding Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Litao Tang, Bin Lyu, Dangge Gao, Yingying Zhou, Yunchuan Wang, Fangxing Wang, Zhangting Jia, Yatong Fu, Ken Chen, Jianzhong Ma
The development of functional textiles combining conventional apparel with advanced technologies for personal health management (PHM) has garnered widespread attention. However, the current PHM textiles often achieve multifunctionality by stacking functional modules, leading to poor durability and scalability. Herein, a scalable and robust PHM textile is designed by integrating electrical, radiative
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Lactobacillus Reuteri Vesicles Regulate Mitochondrial Function of Macrophages to Promote Mucosal and Cutaneous Wound Healing Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Yuan Chen, Xiaoyao Huang, Anqi Liu, Siyuan Fan, Shiyu Liu, Zihan Li, Xiaoxue Yang, Hao Guo, Meiling Wu, Meng Liu, Peisheng Liu, Fei Fu, Siying Liu, Kun Xuan
The interplay between bacteria and their host influences the homeostasis of the human immune microenvironment, and this reciprocal interaction also affects the process of tissue damage repair. A variety of immunomodulatory commensal bacteria reside in the body, capable of delivering membrane vesicles (MVs) to host cells to regulate the local immune microenvironment. This research revealed, for the
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Advanced Multifunctional Hydrogels for Enhanced Wound Healing through Ultra‐Fast Selenol‐SNAr Chemistry Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Yan Wu, Ying Bei, Wenjing Li, Weihong Lu, Jian Zhu, Zhengbiao Zhang, Tinglin Zhang, Sen Liu, Kaiyuan Chen, Hong Jin, Luxin Li, Meng Li, Jie Gao, Xiangqiang Pan
Fabrication of versatile hydrogels in a facile and effective manner represents a pivotal challenge in the field of biomaterials. Herein, a novel strategy is presented for preparing on‐demand degradable hydrogels with multilevel responsiveness. By employing selenol‐dichlorotetrazine nucleophilic aromatic substitution (SNAr) to synthesize hydrogels under mild conditions in a buffer solution, the necessity
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A Three‐in‐One Hybrid Strategy for High‐Performance Semiconducting Polymers Processed from Anisole Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Cheng Liu, Huanhuan Liang, Runze Xie, Quanfeng Zhou, Miao Qi, Chongqing Yang, Xiaodan Gu, Yunfei Wang, Guoxiang Zhang, Jinlun Li, Xiu Gong, Junwu Chen, Lianjie Zhang, Zesheng Zhang, Xiang Ge, Yuanyu Wang, Chen Yang, Yi Liu, Xuncheng Liu
The development of semiconducting polymers with good processability in green solvents and competitive electrical performance is essential for realizing sustainable large‐scale manufacturing and commercialization of organic electronics. A major obstacle is the processability‐performance dichotomy that is dictated by the lack of ideal building blocks with balanced polarity, solubility, electronic structures
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Structural Design and Energy and Environmental Applications of Hydrogen‐Bonded Organic Frameworks: A Systematic Review Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Xiaoming Liu, Guangli Liu, Tao Fu, Keren Ding, Jinrui Guo, Zhenran Wang, Wei Xia, Huayuan Shangguan
Hydrogen‐bonded organic frameworks (HOFs) are emerging porous materials that show high structural flexibility, mild synthetic conditions, good solution processability, easy healing and regeneration, and good recyclability. Although these properties give them many potential multifunctional applications, their frameworks are unstable due to the presence of only weak and reversible hydrogen bonds. In
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Alloying Driven Antiferromagnetic Skyrmions on NiPS3 Monolayer: A First‐Principles Calculation Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Yanxia Wang, Jianpei Xing, Ying Zhao, Yi Wang, Jijun Zhao, Xue Jiang
Topological magnetic states are promising information carriers for ultrahigh‐density and high‐efficiency magnetic storage. Recent advances in two‐dimensional (2D) magnets provide powerful platforms for stabilizing various nanometer‐size topological spin textures within a wide range of magnetic field and temperature. However, non‐centrosymmetric 2D magnets with broken inversion symmetry are scarce in
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Alcohol‐Processable All‐Polymer n‐Type Thermoelectrics Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Xinyi Fan, Jian Liu, Xiaozheng Duan, Hongxiang Li, Sihui Deng, Yazhuo Kuang, Jingyu Li, Chengjiang Lin, Bin Meng, Junli Hu, Shumeng Wang, Jun Liu, Lixiang Wang
The general strategy for n‐type organic thermoelectric is to blend n‐type conjugated polymer hosts with small molecule dopants. In this work, all‐polymer n‐type thermoelectric is reported by dissolving a novel n‐type conjugated polymer and a polymer dopant, poly(ethyleneimine) (PEI), in alcohol solution, followed by spin‐coating to give polymer host/polymer dopant blend film. To this end, an alcohol‐soluble
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Rewiring Photosynthesis by Water‐Soluble Fullerene Derivatives for Solar‐Powered Electricity Generation Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Huawei Zhu, Franco M. Cabrerizo, Jing Li, Tao He, Yin Li
Natural photosynthesis holds great potential to generate clean electricity from solar energy. In order to utilize this process for power generation, it is necessary to rewire photosynthetic electron transport chains (PETCs) of living photosynthetic organisms to redirect more electron flux toward an extracellular electrode. In this study, a semi‐artificial rewiring strategy, which use a water‐soluble
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Chromium‐Induced High Covalent Co–O Bonds for Efficient Anodic Catalysts in PEM Electrolyzer Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Qisheng Yan, Jie Feng, Wenjuan Shi, Wenzhe Niu, Zhuorong Lu, Kai Sun, Xiao Yang, Liangyao Xue, Yi Liu, Youyong Li, Bo Zhang
The proton exchange membrane water electrolyzer (PEMWE), crucial for green hydrogen production, is challenged by the scarcity and high cost of iridium‐based materials. Cobalt oxides, as ideal electrocatalysts for oxygen evolution reaction (OER), have not been extensively applied in PEMWE, due to extremely high voltage and poor stability at large current density, caused by complicated structural variations
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Molecular Determinant Underlying Selective Coupling of Primary G‐Protein by Class A GPCRs Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Qingya Shen, Xinyan Tang, Xin Wen, Shizhuo Cheng, Peng Xiao, Shao‐Kun Zang, Dan‐Dan Shen, Lei Jiang, Yanrong Zheng, Huibing Zhang, Haomang Xu, Chunyou Mao, Min Zhang, Weiwei Hu, Jin‐Peng Sun, Yan Zhang, Zhong Chen
G‐protein‐coupled receptors (GPCRs) transmit downstream signals predominantly via G‐protein pathways. However, the conformational basis of selective coupling of primary G‐protein remains elusive. Histamine receptors H2R and H3R couple with Gs‐ or Gi‐proteins respectively. Here, three cryo‐EM structures of H2R‐Gs and H3R‐Gi complexes are presented at a global resolution of 2.6‐2.7 Å. These structures
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“Cicada Out of the Shell” Deep Penetration and Blockage of the HSP90 Pathway by ROS‐Responsive Supramolecular Gels to Augment Trimodal Synergistic Therapy Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Fashun Li, Jianqin Yan, Chen Wei, Yi Zhao, Xiaowen Tang, Long Xu, Bin He, Yong Sun, Jing Chang, Yan Liang
Deep penetration and downregulation of heat shock protein (HSP) expression in multimodal synergistic therapy are promising approaches for curing cancer in clinical trials. However, free small‐molecule drugs and most drug vehicles have a low delivery efficiency deep into the tumor owing to poor drug penetration and hypoxic conditions at the tumor site. In this study, the objective is to use reactive
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Statistical Genomics Analysis of Simple Sequence Repeats from the Paphiopedilum Malipoense Transcriptome Reveals Control Knob Motifs Modulating Gene Expression Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Yingyi Liang, Jing Hao, Jieyu Wang, Guoqiang Zhang, Yingjuan Su, Zhong‐Jian Liu, Ting Wang
Simple sequence repeats (SSRs) are found in nonrandom distributions in genomes and are thought to impact gene expression. The distribution patterns of 48 295 SSRs of Paphiopedilum malipoense are mined and characterized based on the first full‐length transcriptome and comprehensive transcriptome dataset from 12 organs. Statistical genomics analyses are used to investigate how SSRs in transcripts affect
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Multifunctional Fluoropolymer‐Engineered Magnetic Nanoparticles to Facilitate Blood‐Brain Barrier Penetration and Effective Gene Silencing in Medulloblastoma Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Helen Forgham, Jiayuan Zhu, Xumin Huang, Cheng Zhang, Heather Biggs, Liwei Liu, Yi Cheng Wang, Nicholas Fletcher, James Humphries, Gary Cowin, Karine Mardon, Maria Kavallaris, Kristofer Thurecht, Thomas P. Davis, Ruirui Qiao
Patients with brain cancers including medulloblastoma lack treatments that are effective long‐term and without side effects. In this study, a multifunctional fluoropolymer‐engineered iron oxide nanoparticle gene‐therapeutic platform is presented to overcome these challenges. The fluoropolymers are designed and synthesized to incorporate various properties including robust anchoring moieties for efficient
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Non‐Invasive Hemodynamic Monitoring System Integrating Spectrometry, Photoplethysmography, and Arterial Pressure Measurement Capabilities Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Jukka‐Pekka Sirkiä, Tuukka Panula, Matti Kaisti
Minimally invasive and non‐invasive hemodynamic monitoring technologies have recently gained more attention, driven by technological advances and the inherent risk of complications in invasive techniques. In this article, an experimental non‐invasive system is presented that effectively combines the capabilities of spectrometry, photoplethysmography (PPG), and arterial pressure measurement. Both time‐
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Revealing the MRI‐Contrast in Optically Cleared Brains Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Shimrit Oz, Galit Saar, Shunit Olszakier, Ronit Heinrich, Mykhail O. Kompanets, Shai Berlin
The current consensus holds that optically‐cleared specimens are unsuitable for Magnetic Resonance Imaging (MRI); exhibiting absence of contrast. Prior studies combined MRI with tissue‐clearing techniques relying on the latter's ability to eliminate lipids, thereby fostering the assumption that lipids constitute the primary source of ex vivo MRI‐contrast. Nevertheless, these findings contradict an
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High‐Entropy Oxides for Rechargeable Batteries Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Biao Ran, Huanxin Li, Ruiqi Cheng, Zhaohui Yang, Yi Zhong, Yonghong Qin, Chao Yang, Chaopeng Fu
High‐entropy oxides (HEOs) have garnered significant attention within the realm of rechargeable batteries owing to their distinctive advantages, which encompass diverse structural attributes, customizable compositions, entropy‐driven stabilization effects, and remarkable superionic conductivity. Despite the brilliance of HEOs in energy conversion and storage applications, there is still lacking a comprehensive
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A Soft Collaborative Robot for Contact‐based Intuitive Human Drag Teaching Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Shoulu Gong, Wenbo Li, Jiahao Wu, Bohan Feng, Zhiran Yi, Xinyu Guo, Wenming Zhang, Lei Shao
Soft material‐based robots, known for their safety and compliance, are expected to play an irreplaceable role in human‐robot collaboration. However, this expectation is far from real industrial applications due to their complex programmability and poor motion precision, brought by the super elasticity and large hysteresis of soft materials. Here, a soft collaborative robot (Soft Co‐bot) with intuitive
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Compositional Analysis of Complex Mixtures using Automatic MicroED Data Collection Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Johan Unge, Jieye Lin, Sara J Weaver, Ampon Sae Her, Tamir Gonen
Quantitative analysis of complex mixtures, including compounds having similar chemical properties, is demonstrated using an automatic and high throughput approach to microcrystal electron diffraction (MicroED). Compositional analysis of organic and inorganic compounds can be accurately executed without the need of diffraction standards. Additionally, with sufficient statistics, small amounts of compounds
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Ultralow Strain‐Induced Emergent Polarization Structures in a Flexible Freestanding BaTiO3 Membrane Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Jie Wang, Zhen Liu, Qixiang Wang, Fang Nie, Yanan Chen, Gang Tian, Hong Fang, Bin He, Jinrui Guo, Limei Zheng, Changjian Li, Weiming Lü, Shishen Yan
The engineering of ferroic orders, which involves the evolution of atomic structure and local ferroic configuration in the development of next‐generation electronic devices. Until now, diverse polarization structures and topological domains are obtained in ferroelectric thin films or heterostructures, and the polarization switching and subsequent domain nucleation are found to be more conducive to
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Hybrid Membrane‐Coated Nanoparticles for Precise Targeting and Synergistic Therapy in Alzheimer's Disease Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Rong‐Rong Lin, Lu‐Lu Jin, Yan‐Yan Xue, Zhe‐Sheng Zhang, Hui‐Feng Huang, Dian‐Fu Chen, Qian Liu, Zheng‐Wei Mao, Zhi‐Ying Wu, Qing‐Qing Tao
The blood brain barrier (BBB) limits the application of most therapeutic drugs for neurological diseases (NDs). Hybrid cell membrane‐coated nanoparticles derived from different cell types can mimic the surface properties and functionalities of the source cells, further enhancing their targeting precision and therapeutic efficacy. Neuroinflammation has been increasingly recognized as a critical factor
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A Dynamic Ultrasound Phantom with Tissue‐Mimicking Mechanical and Acoustic Properties Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Sara V. Fernandez, Jin‐Hoon Kim, David Sadat, Colin Marcus, Emma Suh, Rachel Mclntosh, Aastha Shah, Canan Dagdeviren
Tissue‐mimicking phantoms are valuable tools that aid in improving the equipment and training available to medical professionals. However, current phantoms possess limited utility due to their inability to precisely simulate multiple physical properties simultaneously, which is crucial for achieving a system understanding of dynamic human tissues. In this work, novel materials design and fabrication
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Reaction Mechanism and Performance of Innovative 2D Germanane‐Silicane Alloys: SixGe1−xH Electrodes in Lithium‐Ion Batteries Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Shuangying Wei, Tomáš Hartman, Stefanos Mourdikoudis, Xueting Liu, Gang Wang, Evgeniya Kovalska, Bing Wu, Jalal Azadmanjiri, Ruizhi Yu, Levna Chacko, Lukas Dekanovsky, Filipa M. Oliveira, Min Li, Jan Luxa, Saeed Jamali Ashtiani, Jincang Su, Zdeněk Sofer
The adjustable structures and remarkable physicochemical properties of 2D monoelemental materials, such as silicene and germanene, have attracted significant attention in recent years. They can be transformed into silicane (SiH) and germanane (GeH) through covalent functionalization via hydrogen atom termination. However, synthesizing these materials with a scalable and low‐cost fabrication process
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Cascade Reactions Catalyzed by Gold Hybrid Nanoparticles Generate CO Gas Against Periodontitis in Diabetes Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Yi Wang, Tengda Chu, Ting Jin, Shengming Xu, Cheng Zheng, Jianmin Huang, Sisi Li, Lixia Wu, Jianliang Shen, Xiaojun Cai, Hui Deng
The treatment of diabetic periodontitis poses a significant challenge due to the presence of local inflammation characterized by excessive glucose concentration, bacterial infection, and high oxidative stress. Herein, mesoporous silica nanoparticles (MSN) are embellished with gold nanoparticles (Au NPs) and loaded with manganese carbonyl to prepare a carbon monoxide (CO) enhanced multienzyme cooperative
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Magnetic Nanoparticle‐Assisted Non‐Viral CRISPR‐Cas9 for Enhanced Genome Editing to Treat Rett Syndrome Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Hyeon‐Yeol Cho, Myungsik Yoo, Thanapat Pongkulapa, Hudifah Rabie, Alysson R. Muotri, Perry T. Yin, Jeong‐Woo Choi, Ki‐Bum Lee
The CRISPR‐Cas9 technology has the potential to revolutionize the treatment of various diseases, including Rett syndrome, by enabling the correction of genes or mutations in human patient cells. However, several challenges need to be addressed before its widespread clinical application. These challenges include the low delivery efficiencies to target cells, the actual efficiency of the genome‐editing
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Alleviating Recombinant Tissue Plasminogen Activator‐induced Hemorrhagic Transformation in Ischemic Stroke via Targeted Delivery of a Ferroptosis Inhibitor Adv. Sci. (IF 15.1) Pub Date : 2024-04-22 Yan‐Qin Geng, Li‐Na Qiu, Yuan‐Qiu Cheng, Juan‐Juan Li, Yi‐Lin Ma, Cheng‐Cheng Zhao, Ying Cai, Xue‐Bin Zhang, Jieli Chen, Yu‐Chen Pan, Ke‐Rang Wang, Xiu‐Hua Yao, Dong‐Sheng Guo, Jia‐Ling Wu
Intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) is the primary treatment for ischemic stroke. However, rtPA treatment can substantially increase blood‐brain barrier (BBB) permeability and susceptibility to hemorrhagic transformation. Herein, the mechanism underlying the side effects of rtPA treatment is investigated and demonstrated that ferroptosis plays an important
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Hidden Negative Issues and Possible Solutions for Advancing the Development of High‐Energy‐Density in Lithium Batteries: A Review Adv. Sci. (IF 15.1) Pub Date : 2024-04-20 Atsuo Yamada
This review article discusses the hidden or often overlooked negative issues of large‐capacity cathodes, high‐voltage systems, concentrated electrolytes, and reversible lithium metal electrodes in high‐energy‐density lithium batteries and provides some feasible solutions that can realize the construction of realistic rechargeable batteries with higher energy densities. Similar objective discussion
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Axial Phenoxylation of Aluminum Phthalocyanines for Improved Cannabinoid Sensitivity in OTFT Sensors Adv. Sci. (IF 15.1) Pub Date : 2024-04-20 Halynne R. Lamontagne, Rosemary R. Cranston, Zachary J. Comeau, Cory S. Harris, Adam J. Shuhendler, Benoît H. Lessard
Cannabis producers, consumers, and regulators need fast, accurate, point‐of‐use sensors to detect Δ9‐tetrahydrocannabinol (THC) and cannabidiol (CBD) from both liquid and vapor source samples, and phthalocyanine‐based organic thin‐film transistors (OTFTs) provide a cost‐effective solution. Chloro aluminum phthalocyanine (Cl‐AlPc) has emerged as a promising material due to its unique coordinating interactions
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Directional Polarization of a Ferroelectric Intermediate Layer Inspires a Built‐In Field in Si Anodes to Regulate Li+ Transport Behaviors in Particles and Electrolyte Adv. Sci. (IF 15.1) Pub Date : 2024-04-20 Ming Liu, Wenqiang Xu, Shigang Liu, Bowen Liu, Yang Gao, Bin Wang
The silicon (Si) anode is prone to forming a high electric field gradient and concentration gradient on the electrode surface under high‐rate conditions, which may destroy the surface structure and decrease cycling stability. In this study, a ferroelectric (BaTiO3) interlayer and field polarization treatment are introduced to set up a built‐in field, which optimizes the transport mechanisms of Li+
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Embedding Bifurcations into Pneumatic Artificial Muscle Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Nozomi Akashi, Yasuo Kuniyoshi, Taketomo Jo, Mitsuhiro Nishida, Ryo Sakurai, Yasumichi Wakao, Kohei Nakajima
Harnessing complex body dynamics has long been a challenge in robotics, particularly when dealing with soft dynamics, which exhibit high complexity in interacting with the environment. Recent studies indicate that these dynamics can be used as a computational resource, exemplified by the McKibben pneumatic artificial muscle, a common soft actuator. This study demonstrates that bifurcations, including
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Wearable EMI Shielding Composite Films with Integrated Optimization of Electrical Safety, Biosafety and Thermal Safety Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Liang Li, Yongzhu Yan, Jufu Liang, Jinchuan Zhao, Chaoyi Lyu, Haoxiang Zhai, Xilong Wu, Guizhen Wang
Biomaterial‐based flexible electromagnetic interference (EMI) shielding composite films are desirable in many applications of wearable electronic devices. However, much research focuses on improving the EMI shielding performance of materials, while optimizing the comprehensive safety of wearable EMI shielding materials has been neglected. Herein, wearable cellulose nanofiber@boron nitride nanosheet/silver
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Investigating Novel Therapeutic Approaches for Idiopathic Short Stature: Targeting siRNA and Growth Hormone Delivery to the Growth Plate Using Exosome Nanoparticles Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Jinghong Yuan, Yameng Wang, Yanzhe Huang, Shengqin Li, Xiaowen Zhang, Zhiwen Wu, Wenrui Zhao, Junchao Zhu, Junqiu Zhang, Guowen Huang, Peng Yu, Xigao Cheng, Xinhui Wang, Xijuan Liu, Jingyu Jia
Idiopathic short stature (ISS) is a common childhood condition with largely unknown underlying causes. Recent research highlights the role of circulating exosomes in the pathogenesis of various disorders, but their connection to ISS remains unexplored. In the experiments, human chondrocytes are cocultured with plasma exosomes from ISS patients, leading to impaired chondrocyte growth and bone formation
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Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Ye Yi, Guihui Qin, Hongmei Yang, Hao Jia, Qibing Zeng, Dejin Zheng, Sen Ye, Zhiming Zhang, Tzu‐Ming Liu, Kathy Qian Luo, Chu‐Xia Deng, Ren‐He Xu
Circulating tumor cells (CTCs) shed from primary tumors must overcome the cytotoxicity of immune cells, particularly natural killer (NK) cells, to cause metastasis. The tumor microenvironment (TME) protects tumor cells from the cytotoxicity of immune cells, which is partially executed by cancer‐associated mesenchymal stromal cells (MSCs). However, the mechanisms by which MSCs influence the NK resistance
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Apoptotic Bodies Derived from Fibroblast‐Like Cells in Subcutaneous Connective Tissue Inhibit Ferroptosis in Ischaemic Flaps via the miR‐339‐5p/KEAP1/Nrf2 Axis Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Gaoxiang Yu, Yijie Chen, Ningning Yang, Haojie Zhang, Xuzi Zhang, Yibo Geng, Jiayi Zhao, Zhuliu Chen, Chengji Dong, Lidan Lin, Jianjun Qi, Xuanlong Zhang, Xiaoqiong Jiang, Weiyang Gao, Yuepiao Cai, Xiangyang Wang, Jian Ding, Jian Xiao, Kailiang Zhou
Preventing and treating avascular necrosis at the distal end of the flaps are critical to surgery success, but current treatments are not ideal. A recent study shows that apoptotic bodies (ABs) generated near the site of apoptosis can be taken up and promote cell proliferation. The study reveals that ABs derived from fibroblast‐like cells in the subcutaneous connective tissue (FSCT cells) of skin flaps
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Reductive Sn2+ Compensator for Efficient and Stable Sn‐Pb Mixed Perovskite Solar Cells Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Qiuxiang Wang, Jiaxing Xiong, Yanjun Xing, Xinlei Gan, Wendong Zhu, Rong Xuan, Xiaohui Liu, Like Huang, Yuejin Zhu, Jing Zhang
Tin‐lead (Sn‐Pb) mixed perovskite with a narrow bandgap is an ideal candidate for single‐junction solar cells approaching the Shockley‐Queisser limit. However, due to the easy oxidation of Sn2+, the efficiency and stability of Sn‐Pb mixed perovskite solar cells (PSCs) still lag far behind that of Pb‐based solar cells. Herein, highly efficient and stable FA0.5MA0.5Pb0.5Sn0.5I0.47Br0.03 compositional
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Eutectogel Electrolyte Constructs Robust Interfaces for High‐Voltage Safe Lithium Metal Battery Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Wanbao Wu, Deping Li, Chaochao Gao, Hao Wu, Yiyang Bo, Jichuan Zhang, Lijie Ci, Jiaheng Zhang
Dramatic growth of lithium dendrite, structural deterioration of LiCoO2 (LCO) cathode at high voltages, and unstable electrode/electrolyte interfaces pose significant obstacles to the practical application of high‐energy‐density LCO||Li batteries. In this work, a novel eutectogel electrolyte is developed by confining the nonflammable eutectic electrolyte in a polymer matrix. The eutectogel electrolyte
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Gingerenone A Attenuates Ulcerative Colitis via Targeting IL‐17RA to Inhibit Inflammation and Restore Intestinal Barrier Function Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Jian Liang, Weigang Dai, Chuanghui Liu, Yifan Wen, Chen Chen, Yifei Xu, Song Huang, Shaozhen Hou, Chun Li, Yongming Chen, Wei Wang, Hailin Tang
Ulcerative colitis (UC) is a complicated and recurrent intestinal disease. Currently available drugs for UC treatment are scarce, therefore, novel therapeutic drugs for the UC are urgently to be developed. Gingerenone A (GA) is a phenolic compound known for its anti‐inflammatory effect, but its effect on UC remains unknown. Here, it is shown that GA protects mice against UC, which is closely associated
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Single‐Molecule Electrical Profiling of Peptides and Proteins Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Hongyu Ju, Li Cheng, Mengmeng Li, Kunrong Mei, Suhang He, Chuancheng Jia, Xuefeng Guo
In recent decades, there has been a significant increase in the application of single‐molecule electrical analysis platforms in studying proteins and peptides. These advanced analysis methods have the potential for deep investigation of enzymatic working mechanisms and accurate monitoring of dynamic changes in protein configurations, which are often challenging to achieve in ensemble measurements.
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Peptide Transporter 1‐Mediated Dipeptide Transport Promotes Hepatocellular Carcinoma Metastasis by Activating MAP4K4/G3BP2 Signaling Axis Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Feifeng Song, Zhentao Zhang, Weifeng Liu, Tong Xu, Xiaoping Hu, Qiyue Wang, Wanli Zhang, Luqi Ge, Chengwu Zhang, Qing Hu, Hui Qin, Song Zhang, Xinxin Ren, Weijiao Fan, Yiwen Zhang, Ping Huang
Cancer metastasis is the leading cause of mortality in patients with hepatocellular carcinoma (HCC). To meet the rapid malignant growth and transformation, tumor cells dramatically increase the consumption of nutrients, such as amino acids. Peptide transporter 1 (PEPT1), a key transporter for small peptides, has been found to be an effective and energy‐saving intracellular source of amino acids that
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Surface Energy‐Assisted Patterning of Vapor Deposited All‐Inorganic Perovskite Arrays for Wearable Optoelectronics Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Zhangsheng Xu, Xiaojun Pan, Hui Lu, Qiuchun Lu, Yegang Liang, Zeping He, Yizhi Zhu, Yang Yu, Wenqiang Wu, Xun Han, Caofeng Pan
Solution‐based methods for fabricating all‐inorganic perovskite film arrays often suffer from limited control over nucleation and crystallization, resulting in poor homogeneity and coverage. To improve film quality, advanced vapor deposition techniques are employed for continuous film. Here, the vapor deposition strategy to the all‐inorganic perovskite films array, enabling area‐selective deposition
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Propofol Alleviates Anxiety‐Like Behaviors Associated with Pain by Inhibiting the Hyperactivity of PVNCRH Neurons via GABAA Receptor β3 Subunits Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Le Yu, Xiaona Zhu, Kang Peng, Huimin Qin, Kexin Yang, Fang Cai, Ji Hu, Ye Zhang
Pain, a comorbidity of anxiety disorders, causes substantial clinical, social, and economic burdens. Emerging evidence suggests that propofol, the most commonly used general anesthetic, may regulate psychological disorders; however, its role in pain‐associated anxiety is not yet described. This study investigates the therapeutic potential of a single dose of propofol (100 mg kg−1) in alleviating pain‐associated
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Medium‐Entropy Monosilicates Deliver High Corrosion Resistance to Calcium‐Magnesium Aluminosilicate Molten Salt Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Zeyu Chen, Yongzhe Wang, Yiling Huang, Fan Peng, Chucheng Lin, Wei Zheng, Xuemei Song, Yaran Niu, Yi Zeng
For decreasing the global cost of corrosion, it is essential to understand the intricate mechanisms of corrosion and enhance the corrosion resistance of materials. However, the ambiguity surrounding the dominant mechanism of calcium‐magnesium aluminosilicate (CMAS) molten salt corrosion in extreme environments hinders the mix‐and‐matching of the key rare earth elements for increasing the resistance
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Photocatalytic Enantioselective Radical Cascade Multicomponent Minisci Reaction of β‐Carbolines Using Diazo Compounds as Radical Precursors Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Yi‐Jie Gu, Mu‐Peng Luo, Hua Yuan, Guo‐Kai Liu, Shou‐Guo Wang
Here, a photocatalytic asymmetric multicomponent cascade Minisci reaction of β‐carbolines with enamides and diazo compounds is reported, enabling an effective enantioselective radical C─H functionalization of β‐carbolines with high yields and enantioselectivity (up to 83% yield and 95% ee). This enantioselective multicomponent Minisci protocol exhibits step economy, high chemo‐/enantio‐selective control
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Drugtamer‐PROTAC Conjugation Strategy for Targeted PROTAC Delivery and Synergistic Antitumor Therapy Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Shipeng He, Yuxin Fang, Yaojin Zhu, Ziyang Ma, Guoqiang Dong, Chunquan Sheng
Proteolysis‐targeting chimeras (PROTACs) have emerged as a promising strategy for targeted protein degradation and drug discovery. To overcome the inherent limitations of conventional PROTACs, an innovative drugtamer‐PROTAC conjugation approach is developed to enhance tumor targeting and antitumor potency. Specifically, a smart prodrug is designed by conjugating “drugtamer” to a nicotinamide phosp
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Expanding the Palette of SWIR Emitting Nanoparticles Based on Au Nanoclusters for Single‐Particle Tracking Microscopy Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Apolline A. Simon, Lucie Haye, Abdallah Alhalabi, Quentin Gresil, Blanca Martín Muñoz, Stéphane Mornet, Andreas Reisch, Xavier Le Guével, Laurent Cognet
Single‐molecule localization microscopy has proved promising to unravel the dynamics and molecular architecture of thin biological samples down to nanoscales. For applications in complex, thick biological tissues shifting single‐particle emission wavelengths to the shortwave infrared (SWIR also called NIR II) region between 900 to 2100 nm, where biological tissues are more transparent is key. To date
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Defective Lamtor5 Leads to Autoimmunity by Deregulating v‐ATPase and Lysosomal Acidification Adv. Sci. (IF 15.1) Pub Date : 2024-04-19 Wei Zhang, Zhou Sha, Yunzhe Tang, Cuiyuan Jin, Wenhua Gao, Changmai Chen, Lang Yu, Nianyin Lv, Shijia Liu, Feng Xu, Dandan Wang, Liyun Shi
Despite accumulating evidence linking defective lysosome function with autoimmune diseases, how the catabolic machinery is regulated to maintain immune homeostasis remains unknown. Late endosomal/lysosomal adaptor, MAPK and mTOR activator 5 (Lamtor5) is a subunit of the Ragulator mediating mechanistic target of rapamycin complex 1 (mTORC1) activation in response to amino acids, but its action mode