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Analysis of the association between glomerular filtration rate, proteinuria and metabolic syndrome in chronic kidney patients based on longitudinal data. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-07-17 Li Guo,Shanshan Guo,Youlan Gong,Jing Li,Jiandong Li
Chronic kidney disease (CKD) is a group of chronic diseases caused by kidney damage from multiple causes. Metabolic syndrome (MS) manifests as dysfunction of endothelial cells and chronic functional inflammatory states, and may be involved in pathological changes related to renal impairment. Based on longitudinal data analysis of the association between estimated glomerular filtration rate (eGFR),
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Natural compound chaetocin induced DNA damage and apoptosis through reactive oxygen species-dependent pathways in A549 lung cancer cells and in vitro evaluations. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-07-07 Qi Zhang,Feng Ruan,Maonan Yang,Qinghui Wen
There is an urgent need for potential pharmaceutics for lung cancer treatment due to the increased number of lung cancer deaths and the resistance of cancer cells to present therapeutics. The present work aims to discover the anticancer potential of the natural compound chaetocin as a therapeutic for lung cancer treatment. Results showed the significance of chaetocin-induced cell growth inhibition
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Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-06-13 Jingna Luo,Weijun Liu,Qiaoling Xie,Jianshu He,Liyan Jiang
This study was designed to establish the composition of wound dressing based on poly(2-hydroxyethylmethacrylate)-chitosan (PHEM-CS) hydrogels-loaded cerium oxide nanoparticle (CeONPs) composites for cutaneous wound healing on nursing care of the chronic wound. The as-synthesised PHEM-CS/CeONPs hydrogels nanocomposites were characterised by using UV-visible spectroscopy, scanning electron microscopy
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Poly lactic-co-glycolic acid-alginate nanocarrier for efficient drug delivery to liver cancer cells. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-06-13 Mahsa Hoseinzadeh,Mohammad Javad Mokhtari,Farshid Kafilzadeh,Javad Mohammadnejad,Yaghoob Taheri
Efficient drug delivery systems (DDSs) can potentially replace with conventional modalities in cancer therapy, like liver cancer. In this study, a novel folic acid (FA)-functionalised and alginate (Alg)-modified poly lactic-co-glycolic acid (PLGA) nanocomposite was developed for delivery of doxorubicin (Dox) to HepG2 and Huh7 liver cancer cells. After synthesising the nanocarrier, several analytical
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Optimization of solvent evaporation method in liposomal nanocarriers loaded-garlic essential oil (Allium sativum): Based on the encapsulation efficiency, antioxidant capacity, and instability. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-06-05 Salar Ali Ahmed,Mahmood Fadhil Saleem,Hamed Hassanzadeh
This study is aimed to optimise the preparation factors, such as sonication time (5-20 min), cholesterol to lecetin ratio (CHLR) (0.2-0.8), and essential oil content (0.1-0.3 g/100 g) in solvent evaporation method for formulation of liposomal nanocarriers containing garlic essential oil (GEO) in order to find the highest encapsulation efficiency and stability with strongest antioxidant and antimicrobial
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Metabolomics and its applications in assisted reproductive technology. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-05-29 Jingying Gao,Yan Xiao
Metabolomics, an emerging omics technology developed in the post-gene age, is an important part of systems biology. It interprets the pathophysiological state of the subject by quantitatively describing the dynamic changes of metabolites through analytical methods, mainly mass spectrometry (MS) and nuclear magnetic resonance (NMR). Assisted reproductive technology (ART) is a method used to manipulate
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Guest Editorial: Selected extended papers from the 12th international conference on post-genomic technologies. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-05-18 Jing Tu,Lingzhi Wu,Qinyu Ge
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Inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid WZ35 by Cu-based metal organic frameworks. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-05-16 Zhidan Hua,Mingming Han,Lanlan Song,Yongle Yan,Honglang Chen,Jilong Wang,Chao Li,Yanfan Chen,Hanhan Yan,Mayun Chen
Hypoxic pulmonary hypertension (HPH) is a life-threatening disease that occurs due to a lack of oxygen in the lungs, leading to an increase in pulmonary vascular resistance, right ventricular failure, and ultimately death. HPH is a multifactorial disorder that involves multiple molecular pathways, making it a challenge for clinicians to identify effective therapies. Pulmonary artery smooth muscle cells
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Osteogenesis promotion by injectable methacryloylated gelatin containing psoralen and its bacteriostatic properties. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-05-16 Qi Zhang,Fuhang Chu,Yingjie Xu,Xiaonan Wu,Jie Yu,Beibei Cong,Yingtao Wu
The treatment of periodontitis focuses on controlling the progression of inflammation, reducing plaque accumulation, and promoting bone tissue reconstruction. Among them, the reconstruction of irregular bone resorption caused by periodontitis is a long-standing challenge. At present, the local drug treatment of periodontitis is mainly anti-inflammatory and antibacterial drugs. In this study, psoralen
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Lawsone encapsulated polylactic-co-glycolic acid nanoparticles modified with chitosan-folic acid successfully inhibited cell growth and triggered apoptosis in Panc-1 cancer cells. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-05-16 Helia Ghafaripour,Masoud Homayouni Tabrizi,Ehsan Karimi,Niloofar Barati Naeeni
The present research aims to encapsulate lawsone in polylactic-co-glycolic acid (PLGA) nanoparticles modified with folic acid (FA) and chitosan (CS) to study its anticancer effects against Panc-1 cells. The nanoparticles were analysed in means of shape/size and zeta potential index using scanning electron microscope and dynamic light scattering. High-performance liquid chromatography was applied to
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Neutrophil membrane biomimetic delivery system (Ptdser-NM-Lipo/Fer-1) designed for targeting atherosclerosis therapy. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-05-15 Wei Li,Chang Liu,Sichuan Wang,Naifeng Liu
Atherosclerosis is a progressive inflammatory disease characterised by excessive lipid accumulation and inflammatory cell infiltration and is the basis of most cardiovascular diseases and peripheral arterial diseases. Therefore, an effectively targeted delivery system is urgently needed to deliver ferroptosis-specific inhibitors to the site of arterial plaque and the inflammatory microenvironment.
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Xanthine oxidase inhibitory kinetics and mechanism of ellagic acid: In vitro, in silico and in vivo studies. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-05-08 Jianmin Chen,Zemin He,Sijin Yu,Xiaozhen Cai,Danhong Zhu,Yanhua Lin
Ellagic acid (EA), which is widely distributed in many foods, has been found to possess inhibitory activity against xanthine oxidase (XO). However, there is ongoing debate about the difference in XO inhibitory activity between EA and allopurinol. Additionally, the inhibitory kinetics and mechanism of EA on XO are still unclear. Herein, the authors systematically studied the inhibitory effects of EA
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A review of bismuth-based nanoparticles and their applications in radiosensitising and dose enhancement for cancer radiation therapy. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-05-04 Daryoush Shahbazi-Gahrouei,Yazdan Choghazardi,Arezoo Kazemzadeh,Paria Naseri,Saghar Shahbazi-Gahrouei
About 50% of cancer patients receive radiation therapy. Despite the therapeutic benefits of this method, the toxicity of radiation in the normal tissues is unavoidable To improve the quality of radiation therapy, in addition to other methods such as IMRT, IGRT, and high radiation dose, nanoparticles have shown excellent potential when ionising radiation is applied to the target volume. Recently, bismuth-based
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Application of nanotechnology in air purifiers as a viable approach to protect against Corona virus. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-04-25 Ali Mahmoudi,Seyedeh Belin Tavakoly Sany,Marzieh Ahari Salmasi,Ali Bakhshi,Arad Bustan,Sahar Heydari,Majid Rezayi,Fatemeh Gheybi
The outbreak of COVID-19 disease, the cause of severe acute respiratory syndrome, is considered a worldwide public health concern. Although studies indicated that the virus could spread through respiratory particles or droplets in close contact, current research have revealed that the virus stays viable in aerosols for several hours. Numerous investigations have highlighted the protective role of air
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Assessment and evaluation of Chitosan-Metamizole nanoparticles for the fracture healing and analgesic effect: Preclinical study in rat model. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-04-24 Li Yin,Liyong Yuan,Chunling Peng,Qionghua Wang
To assess and evaluate Chitosan-Metamizole nanoparticles for fracture healing and analgesic potential, nanoparticles were formulated using the ionotropic gelation method. The nanoparticles were evaluated for particle size, zeta potential, polydispersity index, loading efficiency, surface characteristics and drug release properties. The analgesic activity was determined in carrageenan-induced arthritic
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Radiosensitising effect of iron oxide-gold nanocomplex for electron beam therapy of melanoma in vivo by magnetic targeting. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-04-21 Mahshad Mohamadkazem,Ali Neshastehriz,Seyed Mohammad Amini,Ali Moshiri,Atousa Janzadeh
Melanoma is a dangerous type of skin cancer sometimes treated with radiotherapy. However, it induces damage to the surrounding healthy tissue and possibly further away areas. Therefore, it is necessary to give a lower dose to the patient with targeted therapy. In this study, the radio-sensitising effect of gold-coated iron oxide nanoparticles on electron beam radiotherapy of a melanoma tumour with
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A paclitaxel prodrug nanoparticles with glutathion/reactive oxygen species dual-responsive and CD206 targeting to improve the anti-tumour effect. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-04-13 Changhai Wang,Yuwen Jiao,Xinyu Zhang,Mingxue Guo,Qing Zhang,Wenjun Hu,Shuang Dong,Tangthianchaichana Jakkree,Yang Lu,Jinling Wang
As a first-line anticancer drug, paclitaxel has shortcomings, such as poor solubility and lack of tumour cell selectivity, which limit its further applications in clinical practice. Therefore, the authors aimed to utilise the characteristics of prodrug and nanotechnology to prepare a reactive oxygen species (ROS) and GSH dual-responsive targeted tumour prodrug nanoparticle Man-PEG-SS-PLGA/ProPTX to
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Stimulus-responsive nano lipidosome for enhancing the anti-tumour effect of a novel peptide Dermaseptin-PP. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-04-11 Changhai Wang,Ziyi Dong,Qing Zhang,Mingxue Guo,Wenjun Hu,Shuang Dong,Tangthianchaichana Jakkree,Yang Lu,Shouying Du
OBJECTIVE Dermaseptin-PP is a newly discovered anticancer peptide with a unique antitumour mechanism and remarkable effect. However, this α-helix anticancer peptide risks haemolysis when used at high doses, which limits its further application. This study aims to prepare a pH-responsive liposome, Der-loaded-pHSL, using nanotechnology to avoid the haemolysis risk of Dermaseptin-PP and increase its accumulation
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Synthesis of Zeolitic imidazolate frameworks-8@ layered double hydroxide polyhedral nanocomposite with designed porous voids as an effective carrier for anti-cancer drug-controlled delivery. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-04-06 Azita Dilmaghani,Kamran Hosseini,Vahideh Tarhriz,Vahid Yousefi
In nanotechnology, compounds containing metal materials are used in pharmaceutical sciences. The main purpose of this research was to introduce a novel method to control the amount of zeolite imidazolate framework (ZIF) in water by forming a protective layer such as layered double hydroxide (LDH). Firstly, ZIF was synthesised as the nucleus of the nanocomposite, and then LDH was formed by in situ synthesis
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Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-03-22 Cyrus Jalili,Amir Kiani,Mohammadreza Gholami,Fariborz Bahrehmand,Sajad Fakhri,Somayeh Kakehbaraei,Seyran Kakebaraei
Alzheimer's disease (AD) is one of the chief neurological difficulties in the aged population, identified through dementia, memory disturbance, and reduced cognitive abilities. β-amyloid (Aβ) plaques aggregations, generation of reactive oxygen species, and mitochondrial dysfunction are among the major signs of AD. Regarding the urgent need for the development of novel treatments for neurodegenerative
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Pb2+ recovery from real water samples by adsorption onto nano Fe3 O4 /chitosan-acrylamide hydrogel ions in real water samples. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-03-21 Arman Samadzadeh Mamaghani,Mohammadreza Manafi,Mohammad Hojjati
This study examined the removal of Pb(II) using magnetic chitosan hydrogel adsorbent from diverse sample waters. Spectrometry was used to track the effects of magnetic acrylamide nanocomposite dose, pH extraction, and contact duration on Pb(II) removal from sample water. This research also looked at adsorption isotherm models for the sorption of Pb(II). The magnetic chitosan hydrogel adsorbent Pb(II)
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Nanopore sensors for single molecular protein detection: Research progress based on computer simulations. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-03-16 Gang Hu,Han Yan,Guohao Xi,Zhuwei Gao,Ziqing Wu,Zuhong Lu,Jing Tu
As biological macromolecules, proteins are involved in important cellular functions ranging from DNA replication and biosynthesis to metabolic signalling and environmental sensing. Protein sequencing can help understand the relationship between protein function and structure, and provide key information for disease diagnosis and new drug design. Nanopore sensors are a novel technology to achieve the
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Recent trends in nanocomposite packaging films utilising waste generated biopolymers: Industrial symbiosis and its implication in sustainability. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-03-13 Zeba Tabassum,Anand Mohan,Narsimha Mamidi,Ajit Khosla,Anil Kumar,Pratima R Solanki,Tabarak Malik,Madhuri Girdhar
Uncontrolled waste generation and management difficulties are causing chaos in the ecosystem. Although it is vital to ease environmental pressures, right now there is no such practical strategy available for the treatment or utilisation of waste material. Because the Earth's resources are limited, a long-term, sustainable, and sensible solution is necessary. Currently waste material has drawn a lot
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Visualised genotyping assay with oral swabs in a closed tube by nested invasive reaction assisted with gold nanoparticle probes. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-03-10 Yijun Li,Wei Wei,Yi Ma,Jingwen Shan,Yanan Chu,LiKun Zhang,Danni Liu,Xueping Ma,Guohua Zhou,Haiping Wu
Single nucleotide polymorphism (SNP) typing is crucial for drug dosage and disease progression. Therefore, a simple and convenient genotyping assay is essential for personalised medicine. Herein, we developed a non-invasive, closed-tube, and visualised method for genotyping. In this method, oral swabs were lysed to directly perform PCR coupled with nested invasive reaction and visualisation based on
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Preparation, characterisation, and in vitro cancer-suppression function of RNA nanoparticles carrying miR-301b-3p Inhibitor. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-03-09 Junjie Zhao,Niu Niu,Fan Yang,Haitao Liu,Weibo Qi
BACKGROUND Multidrug resistance is the biggest barrier on the way to chemotherapy for lung adenocarcinoma (LUAD). For some LUAD patients with cisplatin (DDP) resistance and poor prognoses, the authors put forward RNA nanoparticles (NPs) carrying miR-301b-3p Inhibitor. METHODS The NPs were composed of miR-301b-3p, A549 aptamer (A549apt), and Cyanine 5 in a bottom-up manner with a 3-way-junction (3WJ)
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Evaluation of the parameters affecting the loading of anticancer drug Paclitaxel on coated gold nanoparticles for breast cancer treatment. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-02-27 Afrooz Kharazmi,Neda Attaran
The purpose of this study is the design and synthesis of gold nanoparticles (GNPs) conjugated with paclitaxel and to investigate the parameters affecting the stability of synthesised nanoparticles with drug delivery capability. Here, synthesised GNPs were coated with polyethylene glycol. Then these particles were conjugated with paclitaxel under different conditions and the physical and structural
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Anionic liposomes prepared without organic solvents for effective siRNA delivery. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-02-14 Xiu Han,Yan Lu,Zhaoluo Xu,Yanan Chu,Xueping Ma,Haiping Wu,Bingjie Zou,Guohua Zhou
Currently, organic solvents are necessary for the preparation of anionic liposomes for siRNA delivery. The removal of organic solvent is time-consuming and the residual organic solvent is not only a hidden danger, but also affects the stability of anionic liposomes. Glycerol, which is physiologically compatible and does not need to be removed, is used to promote the dispersion of lipids and the formation
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Chitosan nanoparticle loaded by epidermal growth factor as a potential protein carrier for wound healing: In vitro and in vivo studies. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-02-03 Samaneh Montazeri,Ali Rastegari,Zohreh Mohammadi,Mahboobeh Nazari,Maryam Yousefi,Fatemeh Yazdi Samadi,Somayeh Najafzadeh,Mehdi Aghsami
Epidermal growth factor (EGF) can be efficiently used in wound healing process; but the main obstacle of its clinical use is its susceptibility to proteolysis and maintaining its effective concentration in the site of action. In this study, chitosan nanoparticles containing EGF is formulated using a simple method to increase its stability in physiological pH as well as protect its biological activity
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scRNA-seq data analysis method to improve analysis performance. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-02-02 Junru Lu,Yuqi Sheng,Weiheng Qian,Min Pan,Xiangwei Zhao,Qinyu Ge
With the development of single-cell RNA sequencing technology (scRNA-seq), we have the ability to study biological questions at the level of the individual cell transcriptome. Nowadays, many analysis tools, specifically suitable for single-cell RNA sequencing data, have been developed. In this review, the currently commonly used scRNA-seq protocols are discussed. The upstream processing flow pipeline
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Synergistic effects of 3D chitosan-based hybrid scaffolds and mesenchymal stem cells in orthopaedic tissue engineering. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-01-28 Ping Qi,Zhaohui Ning,Xiuju Zhang
Restoration of damaged bone and cartilage tissue with biomaterial scaffolds is an area of interest in orthopaedics. Chitosan is among the low-cost biomaterials used as scaffolds with considerable biocompability to almost every human tissue. Considerable osteoconductivity, porosity, and appropriate pore size distribution have made chitosan an appropriate scaffold for loading of stem cells and a good
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Fabrication of nano-encapsulated angelica (Heracleum persicum) essential oil for enriching dairy dessert: Physicochemical, rheological and sensorial properties. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-01-27 Narin Mhemmedamin Nanakali
In this study, the nanoemulsions containing angelica essential oil (AEO) was used as a novel nano-carrier for enrichment of dairy dessert. Firstly, oil-in-water nanoemulsions were prepared by different levels of GE (1%, 5%, 10%, and 15%) as the dispersed phase, Tween 80 as surfactant with a constant surfactant to essential oil ratio (1:1), and distillated water as a continuous phase. Droplet size,
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The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-01-20 Yankun Shao,Yilin Xu,Huang Di,Xinxiu Shi,Yingying Wang,Hongyu Liu,Lina Song
Alzheimer's disease (AD) is a neurodegenerative disease with high incidence and widespread attention. There is currently no clear clarification of the pathogenesis. However, ORMDL3 causes ferroptosis in AD, and the potential mechanisms remain unclear. So, this study explore the function of ORMDL3 on ferroptosis in AD and its potential regulatory mechanisms. APPswe/PS1dE9 mice and C57BL/6 mice were
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Optically driven microtools with an antibody-immobilised surface for on-site cell assembly. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-01-16 Shuntaro Mori,Takumi Ito,Hidekuni Takao,Fusao Shimokawa,Kyohei Terao
To enable the accurate reproduction of organs in vitro, and improve drug screening efficiency and regenerative medicine research, it is necessary to assemble cells with single-cell resolution to form cell clusters. However, a method to assemble such forms has not been developed. In this study, a platform for on-site cell assembly at the single-cell level using optically driven microtools in a microfluidic
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The comparison of biodistribution of glutathione PEGylated nanoliposomal doxorubicin formulations prepared by pre-insertion and post-insertion methods for brain delivery in normal mice. IET Nanobiotechnol. (IF 2.3) Pub Date : 2023-01-03 Amin Mehrabian,Saba Dadpour,Mohammad Mashreghi,Javad Zarqi,Anis Askarizadeh,Ali Badiee,Leila Arabi,Seyedeh Alia Moosavian,Mahmoud Reza Jaafari
Several obstacles limit the efficacy of brain tumour treatment, most notably the blood-brain barrier (BBB), which prevents the brain uptake of the majority of accessible medicines due to tight junctions. The presence of glutathione (GSH) receptors on the BBB surface has been demonstrated in numerous papers; consequently, products containing glutathione as a targeting ligand coupled with nanoliposomes
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Photothermal effects of gold nanorods in aqueous solution and gel media: Influence of particle size and excitation wavelength. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-12-21 Zendesha S Mbalaha,David J S Birch,Yu Chen
Gold nanorods (GNRs) have emerged as the most efficient photothermal agent in cancer therapy and photocatalysis. Understanding the influence of the surrounding medium, particle size, and excitation wavelength is critical to optimising the photothermal conversion rate. Here, three pairs of large and small gold nanorods of different aspect ratios and their heat generation under laser radiation at on
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Microelectromechanical system-based biosensor for label-free detection of human cytomegalovirus. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-12-20 Khalid E Alzahrani,Abdulaziz K Assaifan,Mahmoud Al-Gawati,Abdullah M Alswieleh,Hamad Albrithen,Abdullah Alodhayb
The human cytomegalovirus (HCMV) is an asymptomatic common virus that is typically harmless, but in some cases, it can be life threatening. Thus, there is an urgent need to develop novel diagnostic methods and strengthen the efforts to combat this virus. A microcantilever-based biosensor functionalised with the UL83-antibody of HCMV (UL83-HCMV antibody) has been developed to detect the UL83-antigen
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Formulation of nanoemulsion carriers containing Pennyroyal (Mentha pulegium) and Gijavash (Froriepia subpinnata) essential oils for enriching Doogh (Iranian dairy drink). IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-12-07 Marzieh Habibvand,Mahsa Yousefi,Salar Ali Ahmed,Hamed Hassanzadeh
Today, the increasing use of chemical preservatives in foods is considered one of the main problems in food industries. This study aimed to produce the pasteurised Doogh (Iranian yogurt drink) containing a nanoemulsion of essential oil (EO) with appropriate quality. A factorial test based on a completely randomised design with two treatments in three levels, including EO type (pennyroyal, Gijavash
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Trace elements-based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-11-24 Hadil M Alahdal,Sumya Ayad Abdullrezzaq,Hawraz Ibrahim M Amin,Sitah F Alanazi,Abduladheem Turki Jalil,Mehrdad Khatami,Marwan Mahmood Saleh
Hyperthermia is an additional treatment method to radiation therapy/chemotherapy, which increases the survival rate of patients without side effects. Nowadays, Auroshell nanoparticles have attracted much attention due to their precise control over heat use for medical purposes. In this research, iron/gold Auroshell nanoparticles were synthesised using green nanotechnology approach. Auroshell gold@hematite
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The anti-cancer effect of chitosan/resveratrol polymeric nanocomplex against triple-negative breast cancer; an in vitro assessment. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-11-24 Azam Bozorgi,Zahra Haghighi,Mohammad Rasool Khazaei,Maryam Bozorgi,Mozafar Khazaei
Herein, the authors synthesised chitosan nanoparticles (Cs NPs) as a resveratrol (RSV) carrier and evaluated their efficacy in stimulating apoptosis in MDA-MB 231 cells. Blank (Cs NPs) and RSV- Cs NPs (RSV-Cs NPs) were synthesised via ionic gelation and characterised by using fourier-transform infrared spectroscopy (FTIR), Scanning electron microscope, dynamic light scattering/Zeta potential and RSV
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Extraction of alprazolam in biological samples using the dispersive solid-phase method with nanographene oxide grafted with α-pyridylamine. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-11-23 Morteza Parsayi Arvand,Ali Moghimi,Milad Abniki
An effective adsorbent was synthesised from nanographene oxide for the removal of the alprazolam drug from the water sample solution. The dispersive solid-phase extraction method was used with α-pyridylamine grafted nanographene oxide to extract and analyse little amounts of alprazolam in biological materials. Before beginning the experimental analysis process, it is critical to use a simple and accessible
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Biosynthesis of gold nanoparticles in the fruiting body of enoki mushrooms (Flammulina velutipes) under Pb2+ induction. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-11-19 Jingang Mo,Jun Jin,Han Yu,Mingjun Ai,Die Hu,Linlin Li,Kai Song
Fungi can produce many compounds, such as proteins, enzymes, amino acids, and polysaccharides, which are internalised and enriched for metals, and are widely used as reducing and stabilising agents for the biosynthesis of gold nanoparticles (Au NPs). Almost all fungal sources used in the synthesis of the Au NPs are in the form of cell filtrates or mycelial suspensions. However, the culture of cell-free
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Nano-gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-11-07 Liu-Jing Wen,Yue-Sheng Wang,Jie Zhang
The aim of this study was to provide a new effective carrier for rescuing the sensitivity of drug-resistant in breast cancer cells. Nano-gold micelles loaded with Dox and Elacridar (FP-ssD@A-E) were chemically synthesised. With the increase in the amount of Dox and Elacridar, the encapsulation rate of FP-ssD@A-E gradually increased, and the drug loading rate gradually decreased. FP-ss@A-E had a sustained-release
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Effect of different physical factors on the synthesis of spherical gold nanoparticles towards cost-effective biomedical applications. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-11-03 Zahra Bahmanyar,Fatemeh Mohammadi,Ahmad Gholami,Mehdi Khoshneviszadeh
Gold nanoparticles (AuNPs) have great potential to contribute to numerous application fields of biomedicine, which are highly dependent on their physicochemical properties, such as size and shape. Due to the final characteristics, nanoparticles (NPs) are primarily affected by different factors of reaction conditions; the present study aimed to evaluate the effects of manipulating the main physical
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Dutasteride nanoemulsion preparation to inhibit 5-alpha-hair follicle reductase enzymes in the hair follicle; an ex vivo study. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-10-31 Mehri Memar Bashi Aval,Elham Hoveizi,Reza Mombeiny,Mostafa Kazemi,Saeedeh Saeedi,Shima Tavakol
Alopecia is a treatable disorder that usually occurs due to high levels of 5-alpha dihydrotestosterone in hair follicles. To enhance the storage capacity of hair follicles and alleviate the inherent characteristics of dutasteride, 5-alpha reductase inhibitor, a prolonged-release nanocarrier was synthesised, and its influence on rat abdomen's skin was investigated. Results showed the lower ratio of
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Human embryonic stem cells cultured on hydrogels grafted with extracellular matrix protein-derived peptides with polyethylene glycol joint nanosegments. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-10-06 Abdullah A Alarfaj,Abdurahman H Hirad,Murugan A Munusamy,S Suresh Kumar,Akon Higuchi
Human pluripotent stem cells (hPSCs) can be proliferated on completely synthetic materials under xeno-free cultivation conditions using biomaterials grafted with extracellular matrix protein (ECM)-derived peptides. However, cell culture biomaterials grafted with ECM-derived peptides must be prepared using a high concentration of peptide reaction solution (e.g. 1000 μg/ml), whereas the ECM concentration
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The effect of Klotho protein complexed with nanomaterials on bone mesenchymal stem cell performance in the treatment of diabetic ischaemic ulcer. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-09-26 Rui Tang,Gang Zhao,Yuqiao Wang,Ruixue Zhang
A lack of angiogenesis is the key problem in the healing of diabetic foot ulcers. Stem cells have already been proven to have a high potential for angiogenesis. The most important aspects of stem cell therapy are improving the microenvironment, cell homing and continuous factor stimulation. We investigated the effect of Klotho protein to heal wounds by promoting the proliferation and migration of bone
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Biosynthesis of silver nanoparticles using Lawsonia inermis and their biomedical application. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-08-30 Eman Alhomaidi,Saade Abdalkareem Jasim,Hawraz Ibrahim M Amin,Marcos Augusto Lima Nobre,Mehrdad Khatami,Abduladheem Turki Jalil,Saja Hussain Dilfy
Developing biosynthesis of silver nanoparticles (Ag-NPs) using plant extract is an environmentally friendly method to reduce the use of harmful chemical substances. The green synthesis of Ag-NPs by Lawsonia inermis extract and its cellular toxicity and the antimicrobial effect was studied. The physical and chemical properties of synthesised Ag-NPs were investigated using UV-visible spectroscopy, infrared
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Lipid-coated bismuth nanoflower as the thermos-radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-08-29 Shushu Xue,Junrong Jiao,Si Miao,Lijun Wang,Yang Liu,Qingjie Zhang,Qiyue Wang,Yu Xi,Yuanyuan Zhang
Lung metastatic breast cancer (LMBC) leads to a large number of deaths in women with breast cancer, and radiotherapy has been considered the common assay for tumour therapy except for surgery. However, radiotherapy still faces problems of low efficiency due to resistance and easily induced side effects. Here, the authors designed lipid-decorated bismuth-based nanoflowers (DP-BNFs) as both a radiosensitiser
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The role of size in PEGylated liposomal doxorubicin biodistribution and anti-tumour activity. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-08-18 Saba Dadpour,Amin Mehrabian,Mahdieh Arabsalmani,Elaheh Mirhadi,Anis Askarizadeh,Mohammad Mashreghi,Mahmoud Reza Jaafari
The size of nanoliposome-encapsulated drugs significantly affects their therapeutic efficacy, biodistribution, targeting ability, and toxicity profile for the cancer treatment. In the present study, the biodistribution and anti-tumoral activity of PEGylated liposomal Doxorubicin (PLD) formulations with different sizes were investigated. First, 100, 200, and 400 nm PLDs were prepared by remote loading
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Functional characteristics of the rigid elytra in a bamboo weevil beetle Cyrtotrachelus buqueti. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-08-12 Xin Li,Yu Zheng
The bamboo weevil beetle, Cyrtotrachelus buqueti, has evolved a particular flight pattern. When crawling, the beetle folds the flexible hind wings and stuffs under the rigid elytra. During flight, the hind wings are deployed through a series of deployment joints that are passively driven by flapping forces. When the hind wings are fully expanded, the unfolding joint realises self-locking. At this time
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Enhancement of antibacterial activity through phyto-fabrication of silver nanoparticles with Ficus thonningii aqueous extracts. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-08-09 Dickens A Ondigo,Were L L Munyendo,Dickson Andala,Apollo O Maima,Josephat M Mosweta,Kevin W Odhiambo
The World Health Organisation reports higher levels of bacterial resistance to cephalosporins and carbapenems of above 54%. The sufficient redox capabilities of Ficus thonningii phytochemicals for Ag+ reduction to Ag0 and ultimately aggregation to nucleation are exploited for the first time in attempting to enhance the antibacterial activity. Solution colour change to brown due to surface plasmon resonance
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Preparation and characterisation of polycaprolactone-fibroin nanofibrous scaffolds containing allicin. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-08-05 Bita Mollaghadimi
Polycaprolactone (PCL) and silk fibroin are used to make nanofiber wound dressings, and then allicin is added to PCL and silk fibroin to expand antibacterial properties. The polymer solutions are subjected to various electrospinning parameters, and allicin-containing and non-allicin fibres are prepared. Fibres are examined by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy
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Green biosynthesis of magnetic iron oxide nanoparticles using Mentha longifolia for imatinib mesylate delivery. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-06-30 Bahareh Naeimipour,Elham Moniri,Ali Vaziri Yazdi,Raheleh Safaeijavan,Hossein Faraji
In this work, the rapid, facile, and eco-friendly green process was introduced in the preparation of β-cyclodextrin/magnetic iron oxide nanoparticles by using the aqueous Mentha longifolia extracts of Mentha longifolia. The obtained nanoparticles were characterised by Fourier transform infrared spectroscopy, x-ray powder diffraction, field emission scanning electron microscope, and thermogravimetric
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Mathematical model and nanoindentation properties of the claws of Cyrtotrachelus buqueti Guer (Coleoptera: Curculionidae). IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-05-26 Longhai Li,Wei Sun,Ce Guo,Huafeng Guo,Liu Lili,Ping Yu
Scanning electron microscopy (SEM) was used to observe the macroscopic, microscopic, and cross-sectional structures of the claws of Cyrtotrachelus buqueti Guer (Coleoptera: Curculionidae), and a mathematical model of a claw was used to investigate the structure-function relationships. To improve the quality of the SEM images, a non-local means (NLM) algorithm and an improved NLM algorithm were applied
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Investigating preparation and characterisation of diphtheria toxoid-loaded on sodium alginate nanoparticles. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-05-24 Samira Aghamiri,Mojtaba Noofeli,Parvaneh Saffarian,Zahra Salehi Najafabadi,Hamid Reza Goudarzi
This paper aims to investigate the preparation and characterisation of the alginate nanoparticles (NPs) as antigen delivery system loaded by diphtheria toxoid (DT). For this purpose, both the loading capacity (LC) and Loading efficiency (LE) of the alginate NPs burdened by DT are evaluated. Moreover, the effects of different concentrations of sodium alginate and calcium chloride on the NPs physicochemical
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Nanocomposite of electrochemically reduced graphene oxide and gold nanourchins for electrochemical DNA detection. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-04-20 Mostafa Azimzadeh,Zahra Aghili,Behrooz Jannat,Saeid Jafari,Saeed Rafizadeh Tafti,Navid Nasirizadeh
A nanocomposite of graphene oxide and gold nanourchins has been used here to modify the surface of a screen-printed carbon electrode to enhance the sensitivity of the electrochemical DNA detection system. A specific single-stranded DNA probe was designed based on the target DNA sequence and was thiolated to be self-assembled on the surface of the gold nanourchins placed on the modified electrode. Doxorubicin
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Medicinal plants mediated the green synthesis of silver nanoparticles and their biomedical applications. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-04-15 Haajira Beevi Habeeb Rahuman,Ranjithkumar Dhandapani,Santhoshini Narayanan,Velmurugan Palanivel,Ragul Paramasivam,Ramalakshmi Subbarayalu,Sathiamoorthi Thangavelu,Saravanan Muthupandian
The alarming effect of antibiotic resistance prompted the search for alternative medicine to resolve the microbial resistance conflict. Over the last two decades, scientists have become increasingly interested in metallic nanoparticles to discover their new dimensions. Green nano synthesis is a rapidly expanding field of interest in nanotechnology due to its feasibility, low toxicity, eco-friendly
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Diverse biotechnological applications of multifunctional titanium dioxide nanoparticles: An up-to-date review. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-04-12 Rabia Javed,Noor Ul Ain,Ayesha Gul,Muhammad Arslan Ahmad,Weihong Guo,Qiang Ao,Shen Tian
Titanium dioxide (TiO2 ) nanoparticles (NPs) are one of the topmost widely used metallic oxide nanoparticles. Whether present in naked form or doped with metals or polymers, TiO2 NPs perform immensely important functions. However, the alteration in size and shape by doping results in improving the physical, chemical, and biological behaviour of TiO2 NPs. Hence, the differential effects of various TiO2
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Rheological properties of wood/bacterial cellulose and chitin nano-hydrogels as a function of concentration and their nano-films properties. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-04-04 Hesamoddin Jannatamani,Ali Motamedzadegan,Mohammad Farsi,Hossein Yousefi
In this study, rheological properties of the Wood Cellulose NanoFibers (WCNF), Bacterial Cellulose NanoFibers (BCNF), and Chitin NanoFibers (ChNF) as well as physical properties of films prepared from each nano-hydrogel were investigated. Each nano-hydrogel was prepared in 2 concentrations of 0.5 and 1 wt% for rheological study. Rheological properties were measured using a rotational rheometer. The
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Toxicity of Ulva lactuca and green fabricated silver nanoparticles against mosquito vectors and their impact on the genomic DNA of the dengue vector Aedes aegypti. IET Nanobiotechnol. (IF 2.3) Pub Date : 2022-03-30 Al Thabiani Aziz
Marine seaweeds are known to have a potential role against microbial and pesticidal activities. Ulva lactuca, a green macroalgae extract analysed through gas chromatography mass spectrometry reveals 31 compounds. Resistance of mosquito vectors to synthetic insecticides remains a major problem. Discovering and applying natural agents to act against disease vectors is challenging. The activities of the