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Hydroxyapatite nano‐pillars on TI‐6Al‐4V: Enhancements in cell spreading and proliferation during cell/surface integration J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-04-17 Sarah Akua Osafo, Precious Osayamen Etinosa, John David Obayemi, Ali Azeko Salifu, Tabiri Asumadu, Desmond Klenam, Benjamin Agyei‐Tuffour, David Dodoo‐Arhin, Abu Yaya, Winston Oluwole Soboyejo
Despite the attractive combinations of cell/surface interactions, biocompatibility, and good mechanical properties of Ti‐6Al‐4V, there is still a need to enhance the early stages of cell/surface integration that are associated with the implantation of biomedical devices into the human body. This paper presents a novel, easy and reproducible method of nanoscale and nanostructured hydroxyapatite (HA)
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A comparative in vitro and in vivo analysis of the impact of copper substitution on the cytocompatibility, osteogenic, and angiogenic properties of a borosilicate bioactive glass J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-04-16 Linn Anna Fiehn, Elke Kunisch, Merve Saur, Marcela Arango‐Ospina, Christian Merle, Sébastien Hagmann, Adrian Stiller, Leena Hupa, Hana Kaňková, Dagmar Galusková, Tobias Renkawitz, Aldo. R. Boccaccini, Fabian Westhauser
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Collagen‐polyurethane‐dextran hydrogels enhance wound healing by inhibiting inflammation and promoting collagen fibrillogenesis J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-04-16 Hilda Aguayo‐Morales, Luis E. Cobos‐Puc, Claudia M. Lopez‐Badillo, Ernesto Oyervides‐Muñoz, Gonzalo Ramírez‐García, Jesús A. Claudio‐Rizo
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In vitro evaluation of bone cell response to novel 3D‐printable nanocomposite biomaterials for bone reconstruction J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-04-15 Zahra Haghpanah, Dibakar Mondal, Nikan Momenbeitollahi, Sadaf Mohsenkhani, Kiyoumars Zarshenas, Yutong Jin, Michael Watson, Thomas Willett, Maud Gorbet
Critically‐sized segmental bone defects represent significant challenges requiring grafts for reconstruction. 3D‐printed synthetic bone grafts are viable alternatives to structural allografts if engineered to provide appropriate mechanical performance and osteoblast/osteoclast cell responses. Novel 3D‐printable nanocomposites containing acrylated epoxidized soybean oil (AESO) or methacrylated AESO
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Correction to “Suspended graphene oxide nanoparticle for accelerated multilayer osteoblast attachment” J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-04-15
Foroutan T, Nazemi N, Tavana M, Kassaee MZ, Motamedi E, Soieshargh S, Zare Zardini H. Suspended graphene oxide nanoparticle for accelerated multilayer osteoblast attachment. J Biomed Mater Res A. 2018 Jan;106(1):293-303. doi:10.1002/jbm.a.36231. Epub 2017 Nov 16. PMID: 28891194. Figure 5 caption: The following reference is added. Nasiri, J., Motamedi, E., & Naghavi, M. R. (2015). Comparative study
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Effect of radiation cross‐linked collagen scaffold in alveolar ridge preservation of extraction socket J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-04-12 Hongwei Li, Chen Yang, Gong Chen, Bozhao Wang, Jian Li, Ling Xu
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In vivo effects of cell seeding technique in an ex vivo regional gene therapy model for bone regeneration J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-04-11 Jennifer A. Bell, Cory K. Mayfield, Kevin Collon, Stephanie Chang, Matthew C. Gallo, Elizabeth Lechtholz‐Zey, Mina Ayad, Osamu Sugiyam, Amy H. Tang, Sang‐Hyun Park, Jay R. Lieberman
When delivering cells on a scaffold to treat a bone defect, the cell seeding technique determines the number and distribution of cells within a scaffold, however the optimal technique has not been established. This study investigated if human adipose‐derived stem cells (ASCs) transduced with a lentiviral vector to overexpress bone morphogenetic protein 2 (BMP‐2) and loaded on a scaffold using dynamic
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Synthetic strategy for the production of electrically polarized polyvinylidene fluoride‐trifluoroethylene—co‐polymer osseo‐functionalized with hydroxyapatite scaffold J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-04-11 Subhasmita Swain, Rojaleen Lenka, Tapash Rautray
The physiological mechanism of bone tissue regeneration is intricately organized and involves several cell types, intracellular, and extracellular molecular signaling networks. To overcome the drawbacks of autografts and allografts, a number of synthetically produced scaffolds have been manufactured by integrating ceramics, polymers, and their hybrid‐composites. Considering the fact that natural bone
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Evaluating the polymerization effectiveness and biocompatibility of bio‐sourced, visible light‐based photoinitiator systems J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-04-04 Rion J. Wendland, Matthew T. Conway, Kristan S. Worthington
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Optimization of Interleukin‐10 incorporation for dendritic cells embedded in Poly(ethylene glycol) hydrogels J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-04-02 Fredrick Bulondo, Julia E. Babensee
Translational research in biomaterials and immunoengineering is leading to the development of novel advanced therapeutics to treat diseases such as cancer, autoimmunity, and viral infections. Dendritic cells (DCs) are at the center of these therapeutics given that they bridge innate and adaptive immunity. The biomaterial system developed herein uses a hydrogel carrier to deliver immunomodulatory DCs
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Zinc‐doped bioactive glass‐functionalized polyetheretherketone to enhance the biological response in bone regeneration J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-22 Xiaoyu Zheng, Han Luo, Jingzhi Li, Zhenyu Yang, Xiaoquan Zhuan, Xiaoquan Li, Yuting Chen, Shicheng Huo, Xiaozhong Zhou
Polyether ether ketone (PEEK) is gaining recognition as a highly promising polymer for orthopedic implants, attributed to its exceptional biocompatibility, ease of processing, and radiation resistance. However, its long‐term in vivo application faces challenges, primarily due to suboptimal osseointegration from postimplantation inflammation and immune reactions. Consequently, biofunctionalization of
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Study on chitosan/gelatin hydrogels containing ceria nanoparticles for promoting the healing of diabetic wound J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-19 Yonghui Wu, Qianqian Wu, Xialian Fan, Lu Yang, Ling Zou, Qingshan Liu, Guangyou Shi, Xiaochao Yang, Keyong Tang
Chronic inflammation at diabetic wound sites results in the uncontrolled accumulation of pro‐inflammatory factors and reactive oxygen species (ROS), which impedes cell proliferation and delays wound healing. To promote the healing of diabetic wounds, chitosan/gelatin hydrogels containing ceria nanoparticles (CNPs) of various sizes were created in the current study. CNPs' efficacy in removing , •OH
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A nontoxic strontium nanoparticle that holds the potential to act upon osteocompetent cells: An in vitro and in vivo characterization J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-16 Larwsk Hayann, Vitor Freire da Rocha, Marina Ferreira Cândido, Raphael Martini Vicente, Luiz H. S. Andrilli, Sandra Y. Fukada, María Sol Brassesco, Pietro Ciancaglini, Edgard Eduard Engel, Ana Paula Ramos
Estrogen deficiency, long‐term immobilization, and/or aging are commonly related to bone mass loss, thus increasing the risk of fractures. One option for bone replacement in injuries caused by either traumas or pathologies is the use of orthopedic cement based on polymethylmethacrylate (PMMA). Nevertheless, its reduced bioactivity may induce long‐term detachment from the host tissue, resulting in the
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pO2 reporter composite hydrogel macroencapsulation devices for magnetic resonance imaging oxygen quantification J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-16 Amy E. Emerson, Yuka Sugamura, Jad Mazboudi, Tuhfah M. Abdallah, Charmayne D. Seaton, Azin Ghasemi, Vikram D. Kodibagkar, Jessica D. Weaver
Hydrogel cell encapsulation devices are a common approach to reduce the need for chronic systemic immunosuppression in allogeneic cell product transplantation. Macroencapsulation approaches are an appealing strategy, as they maximize graft retrievability and cell dosage within a single device; however, macroencapsulation devices face oxygen transport challenges as geometries increase from preclinical
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Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-15 Kaitlin Mrksich, Marshall S. Padilla, Ryann A. Joseph, Emily L. Han, Dongyoon Kim, Rohan Palanki, Junchao Xu, Michael J. Mitchell
RNA‐based therapeutics have gained traction for the prevention and treatment of a variety of diseases. However, their fragility and immunogenicity necessitate a drug carrier. Lipid nanoparticles (LNPs) have emerged as the predominant delivery vehicle for RNA therapeutics. An important component of LNPs is the ionizable lipid (IL), which is protonated in the acidic environment of the endosome, prompting
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Mesenchymal stem cell‐secretome laden photopolymerizable hydrogels for wound healing J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-15 Riddhesh B. Doshi, Devashree Vakil, Thomas G. Molley, Md Shariful Islam, Kristopher A. Kilian, Corey Cunningham, Kuldip S. Sidhu
Mesenchymal stem cell‐derived secretome represents an emerging acellular therapeutic which possess significant opportunity for clinical applications due to its anti‐inflammatory, immunomodulatory, and wound healing properties. However, maintaining therapeutic efficacy and ensuring stability of cell‐based products is challenging, requiring a robust delivery method. Therefore, we designed a hydrogel‐based
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Extrusion 3D‐printed tricalcium phosphate‐polycaprolactone biocomposites for quercetin‐KCl delivery in bone tissue engineering J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-13 Connor Toulou, Vishal Sharad Chaudhari, Susmita Bose
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Impact of crystalline domains on long‐term stability and mechanical performance of anisotropic silk fibroin sponges J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-12 Elizabeth L. Aikman, Asha P. Rao, Yinhao Jia, Emily E. Fussell, Kayleigh E. Trumbull, Janani Sampath, Whitney L. Stoppel
Sponge‐like materials made from regenerated silk fibroin biopolymers are a tunable and advantageous platform for in vitro engineered tissue culture and in vivo tissue regeneration. Anisotropic, three‐dimensional (3D) silk fibroin sponge‐like scaffolds can mimic the architecture of contractile muscle. Herein, we use silk fibroin solution isolated from the cocoons of Bombyx mori silkworms to form aligned
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In vitro and in vivo evaluation of the osseointegration capacity of a polycarbonate‐urethane zirconium‐oxide composite material for application in a focal knee resurfacing implant J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-11 Pieter P. W. van Hugten, Ralph M. Jeuken, Erkan E. Asik, Henk Oevering, Tim J. M. Welting, Corrinus C. van Donkelaar, Jens C. Thies, Peter J. Emans, Alex K. Roth
Currently available focal knee resurfacing implants (FKRIs) are fully or partially composed of metals, which show a large disparity in elastic modulus relative to bone and cartilage tissue. Although titanium is known for its excellent osseointegration, the application in FKRIs can lead to potential stress‐shielding and metal implants can cause degeneration of the opposing articulating cartilage due
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In vivo healing of low temperature deproteinized bovine bone xenograft in a rabbit cranial model J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-11 Dina Abdelmoneim, Dawn Elizabeth Coates, Patrick Schmidlin, Sander Botter, Kai Chun Li, Gemma Claire Porter, Benedict Seo, Warwick John Duncan
The physicochemical properties of grafting materials affect the quality of the osteointegration, resorption rate, and the new bone (NB) formation. This study assessed the physicochemical properties and integration of a low temperature deproteinized bovine bone xenograft (BBX), referred to as optimized MoaBone® (OMB). This novel BBX was physiochemically characterized both pre and post chemical bleaching
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Cover Image J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-11 Brett Stern, Peter Monteleone, Janet Zoldan
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Bioactive poly(salicylic acid)‐poly(citric acid) scaffolds improve diabetic wound repair via regulating HIF‐1α, Nrf2 and macrophage J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-10 Chenxi Xie, Junping Ma, Meng Luo, Yidan Wang, Bo Lei
Diabetic wounds environment is over‐oxidized, over‐inflammatory, leading to difficulties in regenerating blood vessels, and retardation of healing in diabetic wounds. Therefore, diabetic wounds can be treated from the perspective of scavenging oxidative free radicals and reducing the level of inflammation. Herein, we report a bioactive poly(salicylic acid)‐poly(citric acid) (FPSa‐PCG) hydrogel for
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Preparation of calcium phosphate ion clusters through atomization method for biomimetic mineralization of enamel J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-10 Haide Dong, Lin Qiu, Chen Zhu, Wuzhe Fan, Li Liu, Quanfu Deng, Huan Zhang, Weihu Yang, Kaiyong Cai
Dental enamel is a mineralized extracellular matrix, and enamel defect is a common oral disease. However, the self‐repair capacity of enamel is limited due to the absence of cellular components and organic matter. Efficacy of biomimetic enamel mineralization using calcium phosphate ion clusters (CPICs), is an effective method to compensate for the limited self‐healing ability of fully developed enamel
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Improving regulatory T cell production through mechanosensing J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-07 Lingting Shi, Jee Yoon Lim, Lance C. Kam
Induced Tregs (iTregs) have great promise in adoptive immunotherapy for treatment of autoimmune diseases. This report investigates the impacts of substrate stiffness on human Treg induction, providing a powerful yet simple approach to improving production of these cells. Conventional CD4+ human T cells were activated on materials of different elastic modulus and cultured under suppressive conditions
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Expression of concern: Different apoptosis modalities in periprosthetic membranes J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-06
Maurizio Sabbatini , Valentina Piffanelli , Francesca Boccafoschi , Silvia Gatti , Filippo Renò , Michela Bosetti , Massimiliano Leigheb , Alessandro Massè , Cannas Mario , , Biomed. Mater. Res., 92A: 175–184. DOI: 10.1002/jbm.a.32349.The journal publishes this Expression of Concern to notify the readers regarding irregularities identified in Figure 1A and 1B of the above article, published online
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Mineral matrix deposition of MC3T3‐E1 pre‐osteoblastic cells exposed to silicocarnotite and nagelschmidtite bioceramics: In vitro comparison to hydroxyapatite J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-04 July Andrea Rincón‐López, Jennifer Andrea Hermann‐Muñoz, Rainer Detsch, Raúl Rangel‐López, Juan Muñoz‐Saldaña, Sergio Jiménez‐Sandoval, Juan Manuel Alvarado‐Orozco, Aldo R. Boccaccini
This work presents the effect of the silicocarnotite (SC) and nagelschmidtite (Nagel) phases on in vitro osteogenesis. The known hydroxyapatite of biological origin (BHAp) was used as a standard of osteoconductive characteristics. The evaluation was carried out in conventional and osteogenic media for comparative purposes to assess the osteogenic ability of the bioceramics. First, the effect of the
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3D printing of gellan‐dextran methacrylate IPNs in glycerol and their bioadhesion by RGD derivatives J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-03-04 Luca Paoletti, Francesco Baschieri, Claudia Migliorini, Chiara Di Meo, Olivier Monasson, Elisa Peroni, Pietro Matricardi
The ever‐growing need for new tissue and organ replacement approaches paved the way for tissue engineering. Successful tissue regeneration requires an appropriate scaffold, which allows cell adhesion and provides mechanical support during tissue repair. In this light, an interpenetrating polymer network (IPN) system based on biocompatible polysaccharides, dextran (Dex) and gellan (Ge), was designed
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Fabrication of vascularized tissue‐engineered bone models using triaxial bioprinting J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-27 Junbiao Zhang, Srisurang Suttapreyasri, Chidchanok Leethanakul, Bancha Samruajbenjakun
Bone tissue is a highly vascularized tissue. When constructing tissue‐engineered bone models, both the osteogenic and angiogenic capabilities of the construct should be carefully considered. However, fabricating a vascularized tissue‐engineered bone to promote vascular formation and bone generation, while simultaneously establishing nutrition channels to facilitate nutrient exchange within the constructs
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A novel porous titanium with engineered surface for bone defect repair in load‐bearing position J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-27 Wei Liu, Dong Wang, Guo He, Tingting Li, Xianlong Zhang
Porous titanium exhibits low elastic modulus and porous structure is thought to be a promising implant in bone defect repair. However, the bioinert and low mechanical strength of porous titanium have limited its clinical application, especially in load‐bearing bone defect repair. Our previous study has reported an infiltration casting and acid corrosion (IC‐AC) method to fabricate a novel porous titanium
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Lithium‐loaded GelMA‐Phosphate glass fibre constructs: Implications for astrocyte response J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-24 Zalike Keskin‐Erdogan, Nandin Mandakhbayar, Gang Shi Jin, Yu‐Meng Li, David Y. S. Chau, Richard M. Day, Hae‐Won Kim, Jonathan C. Knowles
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2024 as a year of growth for the Journal of Biomedical Materials Research Part A J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-21 J. Kent Leach
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Enhanced osteogenic and bactericidal performance of premixed calcium phosphate cement with photocrosslinked alginate thin film J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-21 Xiulin Shu, Junda Liao, Qian Wang, Lingling Wang, Qingshan Shi, Xiaobao Xie
The increasing prevalence of implant‐associated infections (IAI) in orthopedics remains a public health challenge. Calcium phosphates (CaPs) are critical biomaterials in dental treatments and bone regeneration. It is highly desirable to endow CaPs with antibacterial properties. To achieve this purpose, we developed a photocrosslinked methacrylated alginate co‐calcium phosphate cement (PMA‐co‐PCPC)
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Polymerized cyclodextrin microparticles for sustained antibiotic delivery in lung infections J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-21 Tracey L. Bonfield, Sean T. Zuckerman, Morgan T. Sutton, Julius N. Korley, Horst A. von Recum
Pulmonary infections complicate chronic lung diseases requiring attention to both the pathophysiology and complexity associated with infection management. Patients with cystic fibrosis (CF) struggle with continuous bouts of pulmonary infections, contributing to lung destruction and eventual mortality. Additionally, CF patients struggle with airways that are highly viscous, with accumulated mucus creating
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Assessment of the proteome profile of decellularized human amniotic membrane and its biocompatibility with umbilical cord‐derived mesenchymal stem cells J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-21 Kainat Ahmed, Haadia Tauseef, Jahan Ara Ainuddin, Muneeza Zafar, Irfan Khan, Asmat Salim, Munazza Raza Mirza, Omair Anwar Mohiuddin
Extracellular matrix‐based bio‐scaffolds are useful for tissue engineering as they retain the unique structural, mechanical, and physiological microenvironment of the tissue thus facilitating cellular attachment and matrix activities. However, considering its potential, a comprehensive understanding of the protein profile remains elusive. Herein, we evaluate the impact of decellularization on the human
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The effect of bioactivity of airway epithelial cells using methacrylated gelatin scaffold loaded with exosomes derived from bone marrow mesenchymal stem cells J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-16 Yongsen Li, Zhike Chen, Tian Xia, Haoxin Wan, Yi Lu, Cheng Ding, Fangbiao Zhang, Ziqing Shen, Shu Pan
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3D printing modality effect: Distinct printing outcomes dependent on selective laser sintering (SLS) and melt extrusion J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-13 Jeong Hun Park, Sarah Jo Tucker, Jeong-Kee Yoon, YongTae Kim, Scott J. Hollister
A direct and comprehensive comparative study on different 3D printing modalities was performed. We employed two representative 3D printing modalities, laser- and extrusion-based, which are currently used to produce patient-specific medical implants for clinical translation, to assess how these two different 3D printing modalities affect printing outcomes. The same solid and porous constructs were created
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Degradation protection and enhanced biocompatibility of Mg alloys pretreated with plasma proteins J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-08 Xian Wei, Jiajia Meng, Sujie Ma, Yanchun Li, Hong Qing, Xubiao Peng, Qing Zhao
After implantation of the Mg alloy in the human body, the adsorption of plasma protein on surface will cause a series of cell reactions and affect the degradation of Mg alloys. Herein, in vitro biological reactions of the ZK60 and AZ31 Mg alloys are analyzed in plasma protein environment. Combined with mass spectrometry analysis of the type of adsorbed proteins, it is shown that proteins such as fibrinogen
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Ultrasmall polyvinylpyrrolidone-modified iridium nanoparticles with antioxidant and anti-inflammatory activity for acute pancreatitis alleviation J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-06 Wenzhang Jin, Xueting Xie, Shuqi Shen, Xingjian Zhou, Shunfu Wang, Lijiang Zhang, Xiang Su
Acute pancreatitis (AP) is a common and serious acute inflammatory disease with high severity rate and mortality. Inflammation and oxidative stress play an extremely important role in the development of AP disease. Polyvinylpyrrolidone-modified iridium nanoparticles (IrNP-PVP) have multienzyme mimetic activity, and the aim of this article is to discuss the therapeutic alleviative effects of the ultrasmall
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Wharton's jelly-derived multifunctional hydrogels: New tools to promote intervertebral disc regeneration in vitro and ex vivo J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-02-03 Letizia Penolazzi, Anna Chierici, Maria Pina Notarangelo, Beatrice Dallan, Gina Lisignoli, Elisabetta Lambertini, Pantaleo Greco, Roberta Piva, Claudio Nastruzzi
The degeneration of intervertebral disc (IVD) is a disease of the entire joint between two vertebrae in the spine caused by loss of extracellular matrix (ECM) integrity, to date with no cure. The various regenerative approaches proposed so far have led to very limited successes. An emerging opportunity arises from the use of decellularized ECM as a scaffolding material that, directly or in combination
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Characterization of aTiO2 surfaces functionalized with CAP-p15 peptide J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-01-29 Guadalupe Ureiro-Cueto, Sandra E. Rodil, Maricela Santana-Vázquez, Lia Hoz-Rodriguez, Higinio Arzate, Gonzalo Montoya-Ayala
Functionalization of Titanium implants using adequate organic molecules is a proposed method to accelerate the osteointegration process, which relates to topographical, chemical, mechanical, and physical features. This study aimed to assess the potential of a peptide derived from cementum attachment protein (CAP-p15) adsorbed onto aTiO2 surfaces to promote the deposition of calcium phosphate (CaP)
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Hydrogel foam dressings with angiogenic and immunomodulatory factors from mesenchymal stem cells J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-01-25 Ziyang Lan, Alan Fletcher, Elizabeth C. Bender, Wenbai Huang, Laura J. Suggs, Elizabeth Cosgriff-Hernandez
Stem cell therapy and skin substitutes address the stalled healing of chronic wounds in order to promote wound closure; however, the high cost and regulatory hurdles of these treatments limit patient access. A low-cost method to induce bioactive healing has the potential to substantially improve patient care and prevent wound-induced limb loss. A previous study reported that bioactive factors derived
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Fluoride-treated rare earth-free magnesium alloy ZK30: An inert and bioresorbable material for bone fracture treatment devices J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-01-18 Hirotaka Watanabe, Wei Xu, Haruka Uno, Yuki Uraya, Masanori Kugita, Yoshihiro Komohara, Takuro Niidome, Makoto Sasaki, Ichiro Shimizu, Nobuyuki Fujita, Yusuke Kawano
Bone fractures represent a common health problem, particularly in an increasingly aging population. Bioresorbable magnesium (Mg) alloy-based implants offer promising alternatives to traditional metallic implants for the treatment of bone fractures because they eliminate the need for implant removal after healing. The Mg-Y-rare-earth (RE)-Zr alloy WE43, designed for orthopedic implants, has received
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Dexamethasone eluting polydopaminated polycaprolactone-poly (lactic-co-glycolic) acid for treatment of tracheal stenosis J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-01-10 Jacob Morand, Phillip McClellan, Ilaha Isali, Yusuf Dikici, Di Fan, Longshun Li, Andrew J. Shoffstall, Ozan Akkus, Mark Weidenbecher
Tracheal stenosis is commonly caused by injury, resulting in inflammation and fibrosis. Inhibiting inflammation and promoting epithelization can reduce recurrence after initial successful treatment of tracheal stenosis. Steroids play an important role in tracheal stenosis management. This study in vitro evaluated effectiveness of a polydopaminated polycaprolactone stent coated with dexamethasone-eluting
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Poly(N-isopropylacrylamide) based smart nanofibrous scaffolds for use as on-demand delivery systems for oral and dental tissue regeneration J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2024-01-08 Dina S. Farahat, Ming Dang, Abeer El-Fallal, Nadia Badr, Peter X. Ma
Stimuli-responsive domains capable of releasing loaded molecules, “on-demand,” have garnered increasing attention due to their enhanced delivery, precision targeting, and decreased adverse effects. The development of an on-demand delivery system that can be easily triggered by dental clinicians might have major roles in dental and oral tissue engineering. A series of random graft poly(NIPAm-co-HEMA-Lactate)
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Vascularization of PEGylated fibrin hydrogels increases the proliferation of human iPSC-cardiomyocytes J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-28 Ethan J. Vanderslice, Staunton G. H. Golding, Jeffrey G. Jacot
Studies have long sought to develop engineered heart tissue for the surgical correction of structural heart defects, as well as other applications and vascularization of this tissue has presented a challenge. Recent studies suggest that vascular cells and a vascular network may have regenerative effects on implanted cardiomyocytes (CM) and nearby heart tissue separate from perfusion of oxygen and nutrients
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Special issue: Frontiers in biomaterials for cardiovascular health J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-21 Chris A. Bashur, Ngan F. Huang
The field of cardiovascular biomaterials offers the potential for development of therapeutic products to treat cardiovascular diseases. Among their uses, biomaterials enable tunable and localized delivery of therapeutic cargo, exert immunomodulatory effects, and provide three-dimensional environments that support tissue engineering and morphogenesis. Recent annual meetings of the Society for Biomaterials
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Compliant substrates mitigate the senescence associated phenotype of stress induced mesenchymal stromal cells J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-14 Robert C. H. Gresham, Andrea C. Filler, Shierly W. Fok, Molly Czachor, Natalie Schmier, Claire Pearson, Chelsea Bahney, J. Kent Leach
Mesenchymal stromal cells (MSCs) are a promising cell population for musculoskeletal cell-based therapies due to their multipotent differentiation capacity and complex secretome. Cells from younger donors are mechanosensitive, evidenced by changes in cell morphology, adhesivity, and differentiation as a function of substrate stiffness in both two- and three-dimensional culture. However, MSCs from older
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Cationic micelle delivery of a multi-epitope vaccine candidate derived from tumor-associated antigens, causing regression in established CT26 colorectal tumors in mice J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-13 Faezeh Sabzehei, Amir Hossein Taromchi, Ali Ramazani, Keivan Nedaei, Abdolamir Feizi, Shahram Arsang-Jang, Hossein Danafar
Among all the cancers, colorectal cancer (CRC) has the third mortality rank in both genders. Cancer vaccines have shown promising results in boosting patients' immune systems to fight cancer. Using the IEDB database, we predicted mouse MHC-I (H2-Ld) binding epitopes from four tumor-associated antigens (APC, KRAS, TP53, and PIK3CA) and designed a multi-epitope vaccine. We expressed the candidate vaccine
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Performance assessment of an injectable hyaluronic acid/polylactic acid complex hydrogel with enhanced biological properties as a dermal filler J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-13 Jiajing Zhao, Ziwei Chen, Xiaoshuo Li, Zheren Tong, Zijin Xu, Peishi Feng, Ping Wang
Injectable hyaluronic acid (HA) hydrogel plays an important role in dermal filling. However, conventional HA dermal fillers mostly lack bio-functional diversity and frequently cause adverse reactions because of the chemical stiffness of highly modified degree and crosslinker residues. In this study, polylactic acid (PLA) was embedded into HA hydrogel as a bioactive substance and 1,4-butanediol diglycidyl
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ROS-mediated anticancer effects of EGFR-targeted nanoceria J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-12 Kochurani K. Johnson, Pramod Koshy, Chantal Kopecky, Michelle Devadason, Joanna Biazik, Xiaoran Zheng, Yue Jiang, Xiaochun Wang, Yiling Liu, Jeff Holst, Jia-Lin Yang, Kristopher A. Kilian, Charles C. Sorrell
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Anti-inflammatory and antioxidant activity of elemental sulfur-derived sustainable sulfur quantum dots J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-12-10 Ruchir Priyadarshi, Hyunjin Choi, Hail Kim, Sanghee Han, Zohreh Riahi, Sai Kumar Tammina, Jong-Whan Rhim, Seok-Geun Lee
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Hydrogel-polyurethane fiber composites with enhanced microarchitectural control for heart valve replacement J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-29 Andrew Robinson, Abbey Nkansah, Sanchita Bhat, Shweta Karnik, Sarah Jones, Ashauntee Fairley, Jonathan Leung, Megan Wancura, Michael S Sacks, Lakshmi Prasad Dasi, Elizabeth Cosgriff-Hernandez
Polymeric heart valves offer the potential to overcome the limited durability of tissue based bioprosthetic valves and the need for anticoagulant therapy of mechanical valve replacement options. However, developing a single-phase material with requisite biological properties and target mechanical properties remains a challenge. In this study, a composite heart valve material was developed where an
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Varying the RGD concentration on a hyaluronic acid hydrogel influences dormancy versus proliferation in brain metastatic breast cancer cells J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-28 Kasra Goodarzi, Rachel Lane, Shreyas S. Rao
A majority of breast cancer deaths occur due to metastasis of cancer cells to distant organs. In particular, brain metastasis is very aggressive with an extremely low survival rate. Breast cancer cells that metastasize to the brain can enter a state of dormancy, which allows them to evade death. The brain microenvironment provides biophysical, biochemical, and cellular cues, and plays an important
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Varying the RGD concentration on a hyaluronic acid hydrogel influences dormancy versus proliferation in brain metastatic breast cancer cells J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-28 Kasra Goodarzi, Rachel Lane, Shreyas S. Rao
A majority of breast cancer deaths occur due to metastasis of cancer cells to distant organs. In particular, brain metastasis is very aggressive with an extremely low survival rate. Breast cancer cells that metastasize to the brain can enter a state of dormancy, which allows them to evade death. The brain microenvironment provides biophysical, biochemical, and cellular cues, and plays an important
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Crosslinking strategies of decellularized extracellular matrix in tissue regeneration J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-22 Su Qiao, Tan Peijie, Jiang Nan
By removing the immunogenic cellular components through various decellularization methods, decellularized extracellular matrix (dECM) is considered a promising material in the field of tissue engineering and regenerative medicine with highly preserved physicochemical properties and superior biocompatibility. However, decellularization treatment can lead to some loss of structural integrity, mechanical
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Preparation and characterization of a novel composite acellular matrix/hyaluronic acid thermosensitive hydrogel for interstitial cystitis/bladder pain syndrome J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-16 Wei Guo, Haichao Liu, Jiaxing Zhang, Jianzhong Zhang, Fei Wang, Peng Zhang, Yunbo Yang
Bladder mucosa damage that causes harm to the interstitium is a recognized pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS). The intravesical instillation of drugs is an important second-line therapy, but it is often necessary to use drugs repeatedly in the clinic because of their short residence time in the bladder cavity, which alters the therapeutic effect. To overcome this drawback
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Extrusion 3D-printing and characterization of poly(caprolactone fumarate) for bone regeneration applications J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-16 Bipin Gaihre, Maria D. Astudillo Potes, Xifeng Liu, Maryam Tilton, Emily Camilleri, Asghar Rezaei, Vitalii Serdiuk, Sungjo Park, Fabrice Lucien, Andre Terzic, Lichun Lu
Polycaprolactone fumarate (PCLF) is a cross-linkable PCL derivative extensively considered for tissue engineering applications. Although injection molding has been widely used to develop PCLF scaffolds, platforms developed using such technique lack precise control on architecture, design, and porosity required to ensure adequate cellular and tissue responses. In particular, the scaffolds should provide
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The development of a nucleus pulposus-derived cartilage analog scaffold for chondral repair and regeneration J. Biomed. Mater. Res. Part A (IF 4.9) Pub Date : 2023-11-14 Vishal Joseph Thomas, Nathan Foster Buchweitz, Jay John Baek, Yongren Wu, Jeremy John Mercuri