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Albumin suppresses oxidation of TiNb alloy in the simulated inflammatory environment J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-03-27 Agata Sotniczuk, Damian Kalita, Witold Chromiński, Magdalena Matczuk, Marcin Pisarek, Halina Garbacz
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Emulgel based on fish skin collagen‐microalgae‐silver increased neovascularization and re‐epithelialization of full thickness burn in rats J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-03-27 Francisco Fábio Pereira de Souza, Igor Iuco Castro‐Silva, Fábia Karine Andrade, Adriano Lincoln Albuquerque Mattos, Mirrael de Sousa Lopes, Wallady da Silva Barroso, Bartolomeu Warlene Silva de Souza, Men de Sá Moreira de Souza‐Filho, André Luis Coelho da Silva
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Direct inkjet writing of polylactic acid/β‐tricalcium phosphate composites for bone tissue regeneration: A proof‐of‐concept study J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-03-23 Vasudev Vivekanand Nayak, Vijayavenkataraman Sanjairaj, Rakesh Kumar Behera, James E. Smay, Nikhil Gupta, Paulo G. Coelho, Lukasz Witek
There is an ever‐evolving need of customized, anatomic‐specific grafting materials for bone regeneration. More specifically, biocompatible and osteoconductive materials, that may be configured dynamically to fit and fill defects, through the application of an external stimulus. The objective of this study was to establish a basis for the development of direct inkjet writing (DIW)‐based shape memory
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Improving osseointegration and antimicrobial properties of titanium implants with black phosphorus nanosheets‐hydroxyapatite composite coatings for vascularized bone regeneration J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-03-23 Shilong Ma, Ruize Sun, Yuhui Wang, Yan Wei, Haofeng Xu, Xuanyu Liu, Ziwei Liang, Liqin Zhao, Yinchun Hu, Xiaojie Lian, Meiqing Guo, Di Huang
For decades, titanium implants have shown impressive advantages in bone repair. However, the preparation of implants with excellent antimicrobial properties as well as better osseointegration ability remains difficult for clinical application. In this study, black phosphorus nanosheets (BPNSs) were doped into hydroxyapatite (HA) coatings using electrophoretic deposition. The coatings' surface morphology
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Photocurable extracellular matrix sealant for cessation of venous hemorrhage J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-03-23 Luke E. Schepers, Brooke L. Martindale, Alycia G. Berman, Hannah L. Cebull, William Van Alstine, Sydney E. Hollingshead, Tyler Novak, Craig J. Goergen
Hemorrhage is the second leading cause of death in patients under 46 years of age in the United States. Cessation of hemorrhage prevents hemorrhagic shock and tissue hypoxia. Controlling the bleed via direct pressure or tourniquet is often the first line of defense, but long‐term care requires staples, hemostatic agents, or sealants that seal the vessel and restore blood flow. Here, we compare a new
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Injectable macroporous naturally‐derived apatite bone cement as a potential trabecular bone substitute J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-03-08 Vimal Kumar Dewangan, T. S. Sampath Kumar, Mukesh Doble, Viju Daniel Varghese
In this study, we have formulated a novel apatite bone cements derived from natural sources (i.e. eggshell and fishbone) with improved qualities that is, porosity, resorbability, biological activity, and so forth. The naturally‐derived apatite bone cement (i.e. FBDEAp) was prepared by mixing hydroxyapatite (synthesized from fishbone) and tricalcium phosphate (synthesized from eggshell) as a solid phase
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Biosafety and chemical solubility studies of multiscale crystal‐reinforced lithium disilicate glass‐ceramics J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-03-08 Tong Zhang, Jinrong Liu, Jin Qi, Lingxiang Sun, Xiaoming Liu, Jingyu Yan, Yanjie Zhang, Xiuping Wu, Bing Li
Lithium disilicate (Li2Si2O5) glass‐ceramics are currently a more widely used all‐ceramic restorative material due to their good mechanical properties and excellent aesthetic properties. However, they have a series of problems such as high brittleness and low fracture toughness, which has become the main bottleneck restricting its development. Therefore, in order to compensate for these shortcomings
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Association between blood markers and the progression of osseointegration in percutaneous prostheses patients—A pilot study J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-03-08 Andrew Miller, Sujee Jeyapalina, Jayant P. Agarwal, James Peter Beck
Patients implanted with osseointegrated (OI) prosthetic systems have reported vastly improved upper and lower extremity prosthetic function compared with their previous experience with socket‐suspension systems. However, OI systems have been associated with superficial and deep‐bone infections and implant loosening due, in part, to a failure of the osseointegration process. Although monitoring the
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Zinc‐doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6‐mercaptopurine J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-03-04 Marcel Jakubowski, Łukasz Majchrzycki, Aleksej Zarkov, Adam Voelkel, Mariusz Sandomierski
6‐Mercaptopurine (6MP) is commonly used in the treatment of acute lymphoblastic leukemia as an important agent in maintenance therapy. Despite its therapeutic benefits, 6MP has some limitations during therapy. Taking into account the disadvantages during 6MP therapy, there is a great need to create an appropriate delivery system for this drug. 6MP contains in its structure nitrogen and sulfur atoms
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Development and optimization of kaempferol loaded ethosomes using Box–Behnken statistical design: In vitro and ex‐vivo assessments J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-03-04 Shraddha Singh Raghav, Bhavna Kumar, Neeraj Kumar Sethiya, Shilpa Pahwa
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Evaluation of rabbit adipose derived stem cells fate in perfused multilayered silk fibroin composite scaffold for Osteochondral repair J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-03-04 Sara Zadegan, Bahman Vahidi, Jhamak Nourmohammadi, Asiyeh Shojaee, Nooshin Haghighipour
Development of osteochondral tissue engineering approaches using scaffolds seeded with stem cells in association with mechanical stimulations has been recently considered as a promising technique for the repair of this tissue. In this study, an integrated and biomimetic trilayered silk fibroin (SF) scaffold containing SF nanofibers in each layer was fabricated. The osteogenesis and chondrogenesis of
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Development of guar gum reinforced calcium magnesium phosphate‐based bone biocement J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-24 Vidul Goenka, Anupama Devi V. K., Ceera Manikandan, Amit Kumar Jaiswal
This study aims at developing a calcium magnesium phosphate‐based bone biocement that combines a natural polymer and regenerative properties of bone bonding materials. The formulation of this biocement consists of oxidized guar gum, polydopamine, and calcium magnesium phosphate. The oxidized guar gum is easily soluble in water and has a slightly basic pH, unlike unmodified guar gum, thus allowing a
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Strontium‐loaded 3D intramedullary nail titanium implant for critical‐sized femoral defect in rabbits J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-22 Shintaro Honda, Shunsuke Fujibayashi, Takayoshi Shimizu, Seiji Yamaguchi, Yaichiro Okuzu, Yusuke Takaoka, Soichiro Masuda, Mitsuru Takemoto, Toshiyuki Kawai, Bungo Otsuki, Koji Goto, Shuichi Matsuda
The treatment of critical‐sized bone defects has long been a major problem for surgeons. In this study, an intramedullary nail shaped three‐dimensional (3D)‐printed porous titanium implant that is capable of releasing strontium ions was developed through a simple and cost‐effective surface modification technique. The feasibility of this implant as a stand‐alone solution was evaluated using a rabbit's
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Studying the electrical, mechanical, and biological properties of BCZT–HA composites J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-22 Fatemeh Zare Dehnov, Raziye Hayati, Lobat Tayebi
The piezoelectric properties of natural bone and their influence on bone growth have inspired researchers to study a range of bio‐piezoelectric composite materials. By exploring these materials, researchers aim to understand better, how piezoelectricity can be controlled to promote bone growth and tissue regeneration. In this work, the prominent piezoelectric material, (Ba, Zr) TiO3‐x(Ba,Ca)TiO3, abbreviated
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Aloe vera-based biomaterial ink for 3D bioprinting of wound dressing constructs J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-08 M. Camila Ceballos-Santa, Alfonso Sierra, Iker Martinez Zalbidea, Emily Lazarus, Valeria Marin-Montealegre, Srikanthan Ramesh, Patricia Iglesias, Karin Wuertz-Kozak, Iris V. Rivero
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Repair of a rat calvaria defect with injectable strontium (Sr)-doped polyphosphate dicalcium phosphate dehydrate (P-DCPD) ceramic bone grafts J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-09 David C. Markel, Paula R. Dietz, Bin Wu, Liang Chen, Therese Bou-Akl, Tong Shi, Weiping Ren
The trace element strontium (Sr) enhances new bone formation. However, delivering Sr, like other materials, in a sustained manner from a ceramic bone graft substitute (BGS) is difficult. We developed a novel ceramic BGS, polyphosphate dicalcium phosphate dehydrate (P-DCPD), which delivers embedded drugs in a sustained pattern. This study assessed the in vitro and in vivo performance of Sr-doped P-DCPD
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Characterization of residual debris on packaged hip arthroplasty stems demonstrates the dominance of less than 10 μm sized particulate: Updated USP788 guidelines for orthopedic implants J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-10 Nadim J. Hallab, Salem R. Hallab, Anastasia Alexander, Robin Pourzal
Past evaluation of particle contamination on packaged implants has typically been conducted using US Pharmacopeia (USP) 788, a 1970s pharmaceutical guideline created to evaluate contaminant particles in injectable fluids and syringes. Our objective was to reestablish relevant acceptance criteria for residual orthopedic and other implant debris, including smaller particles (i.e., <10 μm in diameter)
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Systematic enhancement of microbial decontamination efficiency in bone graft processing by means of high hydrostatic pressure using Escherichia coli as a model organism J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-12 Henrike Loeffler, Janine Waletzko-Hellwig, Ralf-Joerg Fischer, Mirko Basen, Marcus Frank, Anika Jonitz-Heincke, Rainer Bader, Annett Klinder
To obtain bone allografts that are safe for transplantation, several processing steps for decellularization and decontamination have to be applied. Currently available processing methods, although well-established, may interfere with the biomechanical properties of the bone. High hydrostatic pressure (HHP) is known to devitalize tissues effectively while leaving the extracellular matrix intact. However
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Degrees of macrophage-facilitated healing in aneurysm occlusion devices J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-12 Del A. Donehoo, Claudia A. Collier, Sabrina N. VandenHeuvel, Sanjana Roy, Spencer C. Solberg, Shreya A. Raghavan
Insufficient healing of aneurysms following treatment with vascular occlusion devices put patients at severe risk of fatal rupture. Therefore, promoting healing and not just occlusion is vital to enhance aneurysm healing. Following occlusion device implantation, healing is primarily orchestrated by macrophage immune cells, ending with fibroblasts depositing collagen to stabilize the aneurysm neck and
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Development, characterization, and biological study of bioglass coatings 45S5 and BioK on zirconia implant surfaces J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-01 Sarah de Oliveira Marco Avelino, Leonardo Alvares Sobral-Silva, Gilmar Patrocínio Thim, Luis Augusto de Almeida-Silva, Juliana dos Santos Lupp, Tiago Moreira Bastos Campos, Luana Marotta Reis de Vasconcellos
Zirconia implants are gaining attention as a viable alternative to titanium implants due to their comparable osseointegration development, improved soft tissue adaptation, and enhanced aesthetics. An encouraging avenue for improving zirconia implant properties involves the potential application of bioactive coatings to their surfaces. These coatings have shown potential for inducing hydroxyapatite
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Enzyme-functionalized hydrogel film for extracorporeal uric acid reduction J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-01 Jaturavit Pantakitcharoenkul, Jad Touma, Goran Jovanovic, Matthew Coblyn
Enzyme replacement therapy for hyperuricemia treatment has been proven effective for critical state hyperuricemia patients. Still, direct administration of recombinant uricase can induce several fatal side effects. To circumvent this drawback, hydrogel protein carriers can be used in platforms for extracorporeal treatment such as microscale-based devices. In this work, calcium alginate and poly-(vinyl
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Thermoplastic polyurethane/POSS nanohybrids: Synthesis, morphology, and biological properties J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-01 Jan Ozimek, Katarzyna Malarz, Anna Mrozek-Wilczkiewicz, Edyta Hebda, Krzysztof Pielichowski
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Copper-doped magnesium phosphate nanopowders for critical size calvarial bone defect intervention J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-01 Sara A. M. El-Sayed, Shaimaa ElShebiney, Hanan H. Beherei, Pradeep Kumar, Yahya E. Choonara, Mostafa Mabrouk
Calvarial defects of bone present difficult clinical situations, and their restoration using biocompatible materials requires special treatments that enable bone regeneration. Magnesium phosphate (MgP) is known as an osteoinductive biomaterial because it contains Mg2+ ions and P ions that enhance the activity of osteoplast cells and help in bone regeneration. In this study, MgP and CuO-doped MgP were
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Varying material thickness of silicone rubber for tunable nitric oxide release J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-02-01 Patrick Maffe, Ryan Devine, Mark Garren, Hitesh Handa
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Novel surface biochemical modifications of urinary catheters to prevent catheter-associated urinary tract infections J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-25 Mohammad Sadegh Safari, Hassan Mohabatkar, Mandana Behbahani
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Sintered fluorapatite scaffolds as an autograft-like engineered bone graft J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-22 Clark Nielson, Jayant Agarwal, James Peter Beck, Jill Shea, Sujee Jeyapalina
Hydroxyapatite (HA)-based materials are widely used as bone substitutes due to their inherent biocompatibility, osteoconductivity, and bio-absorption properties. However, HA scaffolds lack compressive strength when compared to autograft bone. It has been shown that the fluoridated form of HA, fluorapatite (FA), can be sintered to obtain this desired strength as well as slower degradation properties
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Advancements in 3D-printed artificial tendon J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-22 Ahmad Alhaskawi, Haiying Zhou, Yanzhao Dong, Xiaodi Zou, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Abdulla, Tian Tu, Olga Alenikova, Sahar Abdalbary, Hui Lu
Millions of people have been reported with tendon injuries each year. Unfortunately, Tendon injuries are increasing rapidly due to heavy exercise and a highly aging population. In addition, the introduction of 3D-printing technology in the area of tendon repair and replacement has resolved numerous issues and significantly improved the quality of artificial tendons. This advancement has also enabled
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S-Nitroso-N-acetylpenicillamine impregnated latex: A new class of barrier contraception for the prevention of intercourse-associated UTIs J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-22 Sarah N. Wilson, Patrick Maffe, Jitendra Pant, Bryan M. Grommersch, Hitesh Handa
Urinary tract infections (UTIs) are some of the most common infections seen in humans, affecting over half of the female population. Though easily and quickly treatable, if gone untreated for too long, UTIs can lead to narrowing of the urethra as well as bladder and kidney infections. Due to the disease potential, it is crucial to mitigate the development of UTIs throughout healthcare. Unfortunately
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Enhancing osseointegration of titanium implants through MC3T3-E1 protein-gelatin polyelectrolyte multilayers J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-22 Xuhong He, Chaiqiong Guo, Yuhui Wang, Shilong Ma, Xuanyu Liu, Yan Wei, Haofeng Xu, Ziwei Liang, Yinchun Hu, Liqin Zhao, Xiaojie Lian, Di Huang
Titanium and its alloys have found extensive use in the biomedical field, however, implant loosening due to weak osseointegration remains a concern. Improved surface morphology and chemical composition can enhance the osseointegration of the implant. Bioactive molecules have been utilized to modify the surface of the titanium-based material to achieve rapid and efficient osseointegration between the
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Bacterial cellulose as a promising material for pulmonary valve prostheses: In vivo study in a sheep model J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-13 Piotr Siondalski, Magdalena Kołaczkowska, Michał Bieńkowski, Rafał Pęksa, Maciej M. Kowalik, Kinga Dawidowska, Katrien Vandendriessche, Bart Meuris
Currently, no consensus exists regarding the most durable prosthesis for pulmonary valve replacement. Bacterial cellulose is a resistant, nonbiodegradable, nonpyrogenic bioimplant with low hemolysis and clotting properties. We hypothesized that bacterial cellulose heart valve prostheses could be an attractive alternative for pulmonary valve replacement.
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Attachment and proliferation of human gingival fibroblasts seeded on barrier membranes using Wharton's jelly-derived stem cells conditioned medium: An in vitro study J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-08 Mohammadreza Karimi, Seyed Ali Mosaddad, Seyedeh Sara Aghili, Hengameh Dortaj, Seyedeh-Sara Hashemi, Farin Kiany
The effect of Wharton's jelly mesenchymal stem cells conditioned medium (WJMSCs-CM) and zinc oxide nanoparticles (ZnO-NPs) on cultured human gingival fibroblasts on various barrier membranes was investigated in this study. In this study, human gingival fibroblasts were prepared and cultured on three membranes: collagen membrane, acellular dermal matrix (ADM) with ZnO-NPs, and ADM without ZnO-NPs. WJMSCs-CM
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Electrospun nylon 6/hyaluronic acid/chitosan bioactive nanofibrous composite as a potential antibacterial wound dressing J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-08 Amin Foroozandeh, Mohamadreza Shakiba, Amirhosein Zamani, Alireza Tajiki, Mehdi Sheikhi, Mehrab Pourmadadi, Zohreh Pahnavar, Erfan Rahmani, Nafiseh Aghababaei, Hossein Salar Amoli, Majid Abdouss
Hyaluronic acid (HA) and chitosan (CS), as natural biomaterials, display excellent biocompatibility and stimulate the growth and proliferation of fibroblasts. Furthermore, nylon 6 (N6) is a low-cost polymer with good compatibility with human tissues and high mechanical stability. In this study, HA and CS were applied to modify N6 nanofibrous mat (N6/HA/CS) for potential wound dressing. N6/HA/CS nanofibrous
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Effects of aligned PLGA/SrCSH composite scaffolds on in vitro growth and osteogenic differentiation of human mesenchymal stem cells J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-05 Lichu Liu, Pin Luo, Honghong Liao, Kuangyang Yang, Shenyu Yang, Mei Tu
Strontium (Sr) has important functions in bone remodeling. Incorporating strontium-doped α-calcium sulfate hemihydrate (SrCSH) into poly(lactic-co-glycolic acid) (PLGA) fibrous scaffolds were expected to increase its bio-activity and provide a potential material for bone tissue engineering. In the present study, Sr-containing aligned PLGA/SrCSH fibrous scaffolds similar to the architecture of natural
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Finite element analysis of vertebroplasty in the osteoporotic T11-L1 vertebral body: Effects of bone cement formulation J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-05 Subrata Mondal, David B. MacManus, Federica Banche-Niclot, Chiara Vitale-Brovarone, Sonia Fiorilli, Helen O. McCarthy, Nicholas Dunne
Vertebral compression fractures are one of the most severe clinical consequences of osteoporosis and the most common fragility fracture afflicting 570 and 1070 out of 100,000 men and women worldwide, respectively. Vertebroplasty (VP), a minimally invasive surgical procedure that involves the percutaneous injection of bone cement, is one of the most efficacious methods to stabilise osteoporotic vertebral
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Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin-based adhesive for aortic dissections J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-05 Temmei Ito, Ryo Mizuta, Shima Ito, Tetsushi Taguchi
Type-A aortic dissection is an acute injury involving the delamination of the aorta at the parts of the aortic media. Aldehyde crosslinker-containing glues have been used to adhere to the media of the dissected aorta before joining an artificial graft. These glues effectively adhere to the aortic media; however, they show low biocompatibility due to the release of aldehyde compounds. In this study
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Bone regeneration with hydroxyapatite particles loaded in photo-cross-linkable hydrogel: An experimental study J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-05 Yu-si Li, Shan-lin Guo, Julian Choi, Jia-hao Zeng, Jing-wen Zhang, Fang-bing Zhao, Chun-dong Liu, Xiao-Qing Shen, Yuan-Ming Geng
This study explores the use of in situ cross-linked hyaluronic acid methacryloyl (HAMA) and hydroxyapatite particles (HAP) for bone defect repair. Human periodontal ligament stem cells (PDLSCs) were isolated and co-cultured with the HAMA-HAP composite. Osteogenic differentiation was evaluated using Alizarin Red staining, alkaline phosphatase activity quantification, and polymerase chain reaction (PCR)
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Efficacy of collagen conduit wrapping with collagen fibers on nerve regeneration in sciatic nerve injury with partial transection: An experimental study in the rat model J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2024-01-05 Hiromasa Tanaka, Shigeru Kurimoto, Hitoshi Hirata
Peripheral nerve injuries (PNIs) include complete and partial transection, crushing, and chronic compression injuries. Hollow absorbable conduits are used to treat complete transection with short defects, while wrapping the injured part with an absorbent material promotes nerve recovery by inhibiting inflammatory cell infiltration and scar tissue formation in crush injuries. For treatment of partially
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Direct inkjet writing type 1 bovine collagen/β-tricalcium phosphate scaffolds for bone regeneration J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-12-29 Angel Cabrera Pereira, Nick Tovar, Vasudev Vivekanand Nayak, Dindo Q. Mijares, James E. Smay, Andrea Torroni, Roberto L. Flores, Lukasz Witek
Bone tissue has the capacity to regenerate under healthy conditions, but complex cases like critically sized defects hinder natural bone regeneration, necessitating surgery, and use of a grafting material for rehabilitation. The field of bone tissue engineering (BTE) has pioneered ways to address such issues utilizing different biomaterials to create a platform for cell migration and tissue formation
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Effect of gamma irradiation and supercritical carbon dioxide sterilization with Novakill™ or ethanol on the fracture toughness of cortical bone J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-12-20 Mihee Shin, Matthew H. Pelletier, Vedran Lovric, William R. Walsh, Penny J. Martens, Jamie J. Kruzic, Bernd Gludovatz
Sterilization of structural bone allografts is a critical process prior to their clinical use in large cortical bone defects. Gamma irradiation protocols are known to affect tissue integrity in a dose dependent manner. Alternative sterilization treatments, such as supercritical carbon dioxide (SCCO2), are gaining popularity due to advantages such as minimal exposure to denaturants, the lack of toxic
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Bifunctional tissue-engineered composite construct for bone regeneration: The role of copper and fibrin J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-12-20 Azam Bozorgi, Mozafar Khazaei, Maryam Bozorgi, Leila Sabouri, Mansooreh Soleimani, Zahra Jamalpoor
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Review of electrospun microtube array membrane (MTAM)-a novel new class of hollow fiber for encapsulated cell therapy (ECT) in clinical applications J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-12-17 Chee Ho Chew, Hsin-Lun Lee, Amanda Lin Chen, Wan-Ting Huang, Shu-Mei Chen, Yen-Lin Liu, Chien-Chung Chen
Encapsulated cell therapy (ECT) shows significant potential for treating neurodegenerative disorders including Alzheimer's and Parkinson's, which currently lack curative medicines and must be managed symptomatically. This novel technique encapsulates functional cells with a semi-permeable membrane, providing protection while enabling critical nutrients and therapeutic substances to pass through. Traditional
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Characterization and in-vitro assessment of silicon-based apatite microspheres for bone tissue engineering applications J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-12-18 Chien Yi Wee, Quentin Ray Tjieh Lim, Xin Xu, Zhijie Yang, Dong Wang, Eng San Thian
In the field of bone tissue engineering, silicon (Si) has been found as an essential element for bone growth. However, the use of silicon in bioceramics microspheres remains limited. In this work, different weight percentages (0.8, 1.6, and 2.4 wt %) of silicon was incorporated into hydroxyapatite and fabricated into microspheres. 2.4 wt % of Si incorporated into HAp microspheres (2.4 SiHAp) were found
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Preclinical models for studying corticosteroid-induced osteonecrosis of the femoral head J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-12-18 Masanori Tsubosaka, Masahiro Maruyama, Elaine Lui, Junichi Kushioka, Masakazu Toya, Qi Gao, Huaishuang Shen, Xueping Li, Simon Kwoon-Ho Chow, Ning Zhang, Yunzhi Peter Yang, Stuart B. Goodman
Nontraumatic osteonecrosis of the femoral head (ONFH) is a refractory condition that commonly results in femoral head collapse and degenerative arthritis of the hip. In the early stages, surgical procedures for hip preservation, including core decompression (CD), have been developed to prevent progressive collapse of the femoral head. Optimization of bone regeneration and biological augmentation may
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Pit initiation on biomedical alloys—A review J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-12-18 Bruce G. Pound
Biomedical alloys, like many engineering alloys, have chemical or physical heterogeneities at the surface, and such heterogeneities can potentially act as sites for pit initiation. Alloys of particular interest are 316/316L (and 316LVM) stainless steel, nitinol, and CoCr alloys. This review focuses on the sites—generally inclusions—that have been associated with pitting in various studies of biomedical
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Enhanced osteogenicity of the demineralized bone-dermal matrix composite by the optimal partial demineralization for sustained release of bioactive molecules J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-12-12 Tong Ma, Dangli Ren, Jingjing Wang, Feng Fu, Wendell Q. Sun, Hongtao Sun
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Isolation of TiNbN wear particles from a coated metal-on-metal bearing: Morphological characterization and in vitro evaluation of cytotoxicity in human osteoblasts J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-12-12 Marie-Luise Sellin, Anika Seyfarth-Sehlke, Mahammad Aziz, Christian Fabry, Katrin Wenke, Paul Johan Høl, Ivan Rios-Mondragon, Mihaela Roxana Cimpan, Marcus Frank, Rainer Bader, Anika Jonitz-Heincke
To improve the wear resistance of articulating metallic joint endoprostheses, the surfaces can be coated with titanium niobium nitride (TiNbN). Under poor tribological conditions or malalignment, wear can occur on these implant surfaces in situ. This study investigated the biological response of human osteoblasts to wear particles generated from TiNbN-coated hip implants. Abrasive particles were generated
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Poly(lactic acid/caprolactone) bilayer membrane achieves bone regeneration through a prolonged barrier function J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-12-12 Gabriela L. Abe, Jun-Ichi Sasaki, Ririko Tsuboi, Tomoki Kohno, Haruaki Kitagawa, Satoshi Imazato
Guided bone regeneration (GBR) is a treatment strategy used to recover bone volume. Barrier membranes are a key component of GBR protocols, and their properties can impact treatment outcomes. This study investigated the efficacy of an experimental, slow-degrading, bilayer barrier membrane for application in GBR using in vivo animal models. A synthetic copolymer of poly(lactic acid/caprolactone) (PLCL)
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Epidermis of Cereus hildmannianus as a biomimetic scaffold for tissue engineering J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-11-25 Narendra Reddy, Roopa Reddy, Vijaykumar Guna, G. S. Nagananda, Pornanong Aramwit
A thin plastic-like film separated from the epidermis of Cereus hildmannianus has excellent tensile strength, resistance to water and high antimicrobial activity and supports the growth of mouse fibroblast cells. Cactuses are one of the most under explored plant species with high potential for food, materials, pharmaceutical and other applications. Although studies have shown the ability of cactuses
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Interpenetrating alginate network as drug delivery matrix: Effects on protein stability and release J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-11-20 Ana P. F. Monteiro, Aurora Pérez-Jiménez, Claire Spitzlei, Joachim Caucheteux, Vitor Delgado Alves, Stéphanie Lambert, Christian Grandfils
The study investigates the rheological properties and protein release capacity of a uniform hydrogel composed of sodium alginate (SA) and poloxamer (P407). The hydrogel is prepared through the sustained release of calcium ions, resulting in a reinforced and homogeneous interpenetrating networks (IPNs) of SA and P407 polymeric chains. By adjusting the amount of crosslink agent, the hydrogel exhibites
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Biomineralized fluorocanasite-reinforced biocomposite scaffolds demonstrate expedited osteointegration of critical-sized bone defects J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-11-19 Abhijit Vyas, Samiran Mondal, Vijay Shankar Kumawat, Subrata Bandhu Ghosh, Dhaneshwar Mishra, Jayant Sen, Deepak Khare, Ashutosh Kumar Dubey, Samit Kumar Nandi, Sanchita Bandyopadhyay-Ghosh
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Progress of biodegradable polymer application in cardiac occluders J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-11-16 Qiteng Xu, Hongge Fa, Ping Yang, Qinzheng Wang, Quansheng Xing
Cardiac septal defect is the most prevalent congenital heart disease and is typically treated with open-heart surgery under cardiopulmonary bypass. Since the 1990s, with the advancement of interventional techniques and minimally invasive transthoracic closure techniques, cardiac occluder implantation represented by the Amplazter products has been the preferred treatment option. Currently, most occlusion
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Evaluation of physicochemical properties of graphene oxide-decellularized pericardium biohybrid scaffold J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-11-15 Thirumalai Deepak, Bansod Sneha Bharat, Anju R. Babu
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Biodegradable AZ91 magnesium alloy/sirolimus/poly D, L-lactic-co-glycolic acid-based substrate for cardiovascular device application J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-11-15 Monalisha Mohanta, Yugesh Ramdhun, Arunachalam Thirugnanam, Ritvesh Gupta, Devendra Verma, Thirumalai Deepak, Anju R. Babu
Biodegradable drug-eluting stents (DESs) are gaining importance owing to their attractive features, such as complete drug release to the target site. Magnesium (Mg) alloys are promising materials for future biodegradable DESs. However, there are few explorations using biodegradable Mg for cardiovascular stent application. In this present study, sirolimus-loaded poly D, L-lactic-co-glycolic acid (PLGA)-coated/
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Increased stability due to symmetric cement volume in augmented pedicle screws? A biomechanical study J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-11-13 Maximilian Weber, Maximilian Lenz, Philipp Egenolf, Andreas Prescher, Sebastian Walter, Vincent J. Heck, Peer Eysel, Max Joseph Scheyerer
Pedicle screw instrumentation has become “state of the art” in surgical treatment of many spinal disorders. Loosening of pedicle screws due to poor bone mineral density is a frequent complication in osteoporotic patients. As prevalence of osteoporosis and spinal disorders are increasing with an aging demographic, optimizing the biomechanical properties of pedicle screw constructions and therefore outcome
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Cell adhesion molecule immobilized gold surfaces for enhanced neuron-electrode interfaces J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-11-11 Bengu Aktas, Alp Ozgun, Begum Devlet Kilickap, Bora Garipcan
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Chitosan-sodium percarbonate-based hydrogels with sustained oxygen release potential stimulated angiogenesis and accelerated wound healing J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-11-09 Tayyba Sher Waris, Syed Tahir Abbas Shah, Azra Mehmood, Afaq Mushtaq, Mubashra Zehra, Saima Zulfiqar, Anisa Andleeb, Faiza Jabbar, Muhammad Awais Anjum, Aqif Anwar Chaudhry, Ihtesham ur Rehman, Muhammad Yar
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Effects of glass–ceramic produced by the sol–gel route in macrophages recruitment and polarization into bone tissue regeneration J. Biomed. Mater. Res. Part B Appl. Biomater. (IF 3.4) Pub Date : 2023-11-06 Raquel Barroso Parra da Silva, Claudia Cristina Biguetti, Marcelo Salles Munerato, Renato Luis Siqueira, Edgard Dutra Zanotto, Guilherme Halawa Abu Kudo, Gustavo Baroni Simionato, Ana Carolina Zucon Bacelar, Rafael Carneiro Ortiz, Joel Santiago Ferreira-Junior, Idelmo Garcia Rangel-Junior, Mariza Akemi Matsumoto
Effective bone substitute biomaterials remain an important challenge in patients with large bone defects. Glass ceramics produced by different synthesis routes may result in changes in the material physicochemical properties and consequently affect the success or failure of the bone healing response. To investigate the differences in the orchestration of the inflammatory and healing process in bone