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Antioxidant Activity and Mechanism of Action of Amwaprin: A Protein in Honeybee (Apis mellifera) Venom Antioxidants (IF 7.0) Pub Date : 2024-04-17 Bo-Yeon Kim, Kwang-Sik Lee, Byung-Rae Jin
Bee venom contains several bioactive components, including enzymatic and non-enzymatic proteins. There is increasing interest in the bioactive components of bee venom since they have exhibited various pharmacological effects. Recently, Apis mellifera waprin (Amwaprin) was identified as a novel protein in Apis mellifera (honeybee) venom and characterized as an antimicrobial agent. Herein, the novel
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Tricarboxylic Acid Cycle Regulation of Metabolic Program, Redox System, and Epigenetic Remodeling for Bone Health and Disease Antioxidants (IF 7.0) Pub Date : 2024-04-17 Wei-Shiung Lian, Re-Wen Wu, Yu-Han Lin, Yu-Shan Chen, Holger Jahr, Feng-Sheng Wang
Imbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates the development of osteoporosis, which is the leading risk factor of disability in the elderly. Harmonizing the metabolic actions of bone-making cells and bone resorbing cells to the mineralized matrix network is required to maintain bone mass homeostasis. The tricarboxylic acid (TCA) cycle in mitochondria is a crucial
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Tributyrin Supplementation Rescues Chronic–Binge Ethanol-Induced Oxidative Stress in the Gut–Lung Axis in Mice Antioxidants (IF 7.0) Pub Date : 2024-04-17 Anthony Santilli, David Shapiro, Yingchun Han, Naseer Sangwan, Gail A. M. Cresci
Excessive alcohol consumption increases the severity and worsens outcomes of pulmonary infections, often due to oxidative stress and tissue damage. While the mechanism behind this relationship is multifaceted, recent evidence suggests ethanol-induced changes to the gut microbiome impact the gut–lung axis. To assess this, a chronic–binge ethanol feeding mouse model was used to determine how ethanol
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Redox Regulation of Phosphatase and Tensin Homolog by Bicarbonate and Hydrogen Peroxide: Implication of Peroxymonocarbonate in Cell Signaling Antioxidants (IF 7.0) Pub Date : 2024-04-17 Vu Hoang Trinh, Jin-Myung Choi, Thang Nguyen Huu, Dhiraj Kumar Sah, Hyun-Joong Yoon, Sang-Chul Park, Yu-Seok Jung, Young-Keun Ahn, Kun-Ho Lee, Seung-Rock Lee
Phosphatase and tensin homolog (PTEN) is a negative regulator of the phosphoinositide 3-kinases/protein kinase B (PI3K/AKT) signaling pathway. Notably, its active site contains a cysteine residue that is susceptible to oxidation by hydrogen peroxide (H2O2). This oxidation inhibits the phosphatase function of PTEN, critically contributing to the activation of the PI3K/AKT pathway. Upon the stimulation
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Correction: Abbas et al. Bioactive Compounds, Antioxidant, Anti-Inflammatory, Anti-Cancer, and Toxicity Assessment of Tribulus terrestris—In Vitro and In Vivo Studies. Antioxidants 2022, 11, 1160 Antioxidants (IF 7.0) Pub Date : 2024-04-17 Malik Waseem Abbas, Mazhar Hussain, Saeed Akhtar, Tariq Ismail, Muhammad Qamar, Zahid Shafiq, Tuba Esatbeyoglu
In the original publication [...]
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S-Allylmercapto-N-Acetylcysteine (ASSNAC) Attenuates Osteoporosis in Ovariectomized (OVX) Mice Antioxidants (IF 7.0) Pub Date : 2024-04-17 Itay Bleichman, Sahar Hiram-Bab, Yankel Gabet, Naphtali Savion
Osteoporosis is a bone-debilitating disease, demonstrating a higher prevalence in post-menopausal women due to estrogen deprivation. One of the main mechanisms underlying menopause-related bone loss is oxidative stress. S-allylmercapto-N-acetylcysteine (ASSNAC) is a nuclear factor erythroid 2-related factor 2 (Nrf2) activator and cysteine supplier, previously shown to have anti-oxidation protective
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Potential New Therapies “ROS-Based” in CLL: An Innovative Paradigm in the Induction of Tumor Cell Apoptosis Antioxidants (IF 7.0) Pub Date : 2024-04-17 Raffaele Sciaccotta, Sebastiano Gangemi, Giuseppa Penna, Laura Giordano, Giovanni Pioggia, Alessandro Allegra
Chronic lymphocytic leukemia, in spite of recent advancements, is still an incurable disease; the majority of patients eventually acquire resistance to treatment through relapses. In all subtypes of chronic lymphocytic leukemia, the disruption of normal B-cell homeostasis is thought to be mostly caused by the absence of apoptosis. Consequently, apoptosis induction is crucial to the management of this
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Porcine Brain Enzyme Hydrolysate Enhances Immune Function and Antioxidant Defense via Modulation of Gut Microbiota in a Cyclophosphamide-Induced Immunodeficiency Model Antioxidants (IF 7.0) Pub Date : 2024-04-17 Yu Yue, Hye Jeong Yang, Ting Zhang, Chen Li, Min Jung Kim, Keun-Nam Kim, Sunmin Park
This study examined how consuming porcine brain enzyme hydrolysate (PBEH) affects the immune function and composition of the gut microbiota in an immunodeficient animal model. Male Wistar rats aged 6 weeks were fed casein (control), 100 mg/kg body weight (BW), red ginseng extract (positive-control), and 6, 13, and 26 mg PBEH per kg BW (PBEH-L, PBEH-M, and PBEH-H, respectively) daily for 4 weeks. At
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Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative Effects in Melanoma Cells Antioxidants (IF 7.0) Pub Date : 2024-04-17 Peihong Lyu, Huifang Li, Junzhao Wan, Ying Chen, Zhen Zhang, Panpan Wu, Yinsheng Wan, Navindra P. Seeram, Jean Christopher Chamcheu, Chang Liu, Hang Ma
Cannabis and its major cannabinoid cannabidiol (CBD) are reported to exhibit anticancer activity against skin tumors. However, the cytotoxic effects of other minor cannabinoids and synthetic CBD derivatives in melanoma are not fully elucidated. Herein, the antiproliferative activity of a panel of phytocannabinoids was screened against murine (B16F10) and human (A375) melanoma cells. CBD was the most
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Advances in Research on the Activity Evaluation, Mechanism and Structure-Activity Relationships of Natural Antioxidant Peptides Antioxidants (IF 7.0) Pub Date : 2024-04-17 Baoting Xu, Qin Dong, Changxia Yu, Hongyu Chen, Yan Zhao, Baosheng Zhang, Panling Yu, Mingjie Chen
Antioxidant peptides are a class of biologically active peptides with low molecular weights and stable antioxidant properties that are isolated from proteins. In this review, the progress in research on the activity evaluation, action mechanism, and structure-activity relationships of natural antioxidant peptides are summarized. The methods used to evaluate antioxidant activity are mainly classified
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Impact of Adherence to the Mediterranean Diet on Antioxidant Status and Metabolic Parameters in NAFLD Patients: A 24-Month Lifestyle Intervention Study Antioxidants (IF 7.0) Pub Date : 2024-04-17 Maria Magdalena Quetglas-Llabrés, Margalida Monserrat-Mesquida, Cristina Bouzas, Silvia García, Emma Argelich, Miguel Casares, Lucía Ugarriza, Isabel Llompart, Josep A. Tur, Antoni Sureda
Background: The Mediterranean Diet (MedDiet) is recognized as a healthy dietary pattern. Non-alcoholic fatty liver disease (NAFLD) is characterized by the excessive accumulation of fat in the liver. Objectives: To assess the antioxidant status in erythrocytes, plasma, and peripheral blood mononuclear cells (PBMCs) of NAFLD patients following a 24-month lifestyle intervention based on the MedDiet. Adult
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NLRX1 Inhibits LPS-Induced Microglial Death via Inducing p62-Dependent HO-1 Expression, Inhibiting MLKL and Activating PARP-1 Antioxidants (IF 7.0) Pub Date : 2024-04-17 Yu-Ling Huang, Duen-Yi Huang, Vladlen Klochkov, Chi-Ming Chan, Yuan-Shen Chen, Wan-Wan Lin
The activation of microglia and the production of cytokines are key factors contributing to progressive neurodegeneration. Despite the well-recognized neuronal programmed cell death regulated by microglial activation, the death of microglia themselves is less investigated. Nucleotide-binding oligomerization domain, leucine-rich repeat-containing X1 (NLRX1) functions as a scaffolding protein and is
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Chemical Characterization and Biological Properties of Leguminous Honey Antioxidants (IF 7.0) Pub Date : 2024-04-18 Florinda Fratianni, Giuseppe Amato, Maria Neve Ombra, Vincenzo De Feo, Filomena Nazzaro, Beatrice De Giulio
Honey can beneficially act against different human diseases, helping our body to improve its health. The aim of the present study was first to increase knowledge of some biochemical characteristics (amount and composition of polyphenols and volatile organic compounds, vitamin C content) of five Italian legume honeys (alfalfa, astragalus, carob, indigo, and sainfoin). Furthermore, we evaluated their
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Comparison of the Antioxidant Potency of Four Triterpenes of Centella asiatica against Oxidative Stress Antioxidants (IF 7.0) Pub Date : 2024-04-18 Jinyeong Lim, Hana Lee, Seonghwa Hong, Junsoo Lee, Younghwa Kim
We comparatively evaluated the antioxidant properties of key triterpenes from Centella asiatica, including asiatic acid (AA), asiaticoside, madecassic acid, and madecassoside, in several cell types, including skin fibroblasts, macrophages, hepatocytes, and endothelial cells, under conditions promoting oxidative stress. AA conferred the highest viability on Hs68 cells exposed to ultraviolet B (UVB)
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Hormetic Nutrition and Redox Regulation in Gut–Brain Axis Disorders Antioxidants (IF 7.0) Pub Date : 2024-04-18 Maria Scuto, Francesco Rampulla, Giuseppe Maria Reali, Sestina Maria Spanò, Angela Trovato Salinaro, Vittorio Calabrese
The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience and overall human health have received much attention. Recently, the gut–brain axis has attracted prominent interest for preventing and therapeutically impacting neuropathologies and gastrointestinal diseases. Polyphenols and polyphenol-combined nanoparticles in synergy with probiotics have shown to
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Unlocking the Therapeutic Potential of Ellagic Acid for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis Antioxidants (IF 7.0) Pub Date : 2024-04-18 Tharani Senavirathna, Armaghan Shafaei, Ricky Lareu, Lois Balmer
Obesity is in epidemic proportions in many parts of the world, contributing to increasing rates of non-alcoholic fatty liver disease (NAFLD). NAFLD represents a range of conditions from the initial stage of fatty liver to non-alcoholic steatohepatitis (NASH), which can progress to severe fibrosis, through to hepatocellular carcinoma. There currently exists no treatment for the long-term management
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Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved Antioxidants (IF 7.0) Pub Date : 2024-04-18 Simona Serini, Gabriella Calviello
Chemotherapy-induced cognitive impairment or “chemobrain” is a prevalent long-term complication of chemotherapy and one of the more devastating. Most of the studies performed so far to identify the cognitive dysfunctions induced by antineoplastic chemotherapies have been focused on treatment with anthracyclines, frequently administered to breast cancer patients, a population that, after treatment,
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Complexes of Soluble Dietary Fiber and Polyphenols from Lotus Root Regulate High-Fat Diet-Induced Hyperlipidemia in Mice Antioxidants (IF 7.0) Pub Date : 2024-04-16 Zhan Zheng, Weilan Gao, Zhenzhou Zhu, Shuyi Li, Xueling Chen, Giancarlo Cravotto, Yong Sui, Lei Zhou
In this paper, complexes of soluble dietary fiber (SDF) and polyphenols (PPs) isolated from lotus roots were prepared (SDF-PPs), as well as physical mixtures (SDF&PPs), which were given to high-fat-diet (HFD)-fed mice. The results demonstrated that SDF-PPs improve lipid levels and reverse liver injury in hyperlipidemic mice. Western blotting and real-time quantitative Polymerase Chain Reaction (RT-qPCR)
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Inflammatory Cytokines and Chemokines Are Synergistically Induced in a ROS-Dependent Manner by a Co-Culture of Corneal Epithelial Cells and Neutrophil-like Cells in the Presence of Particulate Matter Antioxidants (IF 7.0) Pub Date : 2024-04-16 Zirui Zeng, Yasuhiro Yoshida, Duo Wang, Yuri Fujii, Mengyue Shen, Tatsuya Mimura, Yoshiya Tanaka
Ocular exposure to particulate matter (PM) causes local inflammation; however, the influence of neutrophils on PM-induced ocular inflammation is still not fully understood. In this study, we constructed a system to investigate the role of PM in ocular inflammation using a co-culture of human corneal epithelial cells (HCE-T) and differentiation-induced neutrophils (dHL-60). To investigate whether HCE-T
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18Beta-Glycyrrhetinic Acid Attenuates H2O2-Induced Oxidative Damage and Apoptosis in Intestinal Epithelial Cells via Activating the PI3K/Akt Signaling Pathway Antioxidants (IF 7.0) Pub Date : 2024-04-16 Cui Ma, Fuxi Wang, Jiawei Zhu, Shiyi Wang, Yaqing Liu, Jianfang Xu, Qingyu Zhao, Yuchang Qin, Wei Si, Junmin Zhang
Oxidative stress causes gut dysfunction and is a contributing factor in several intestinal disorders. Intestinal epithelial cell survival is essential for maintaining human and animal health under oxidative stress. 18beta-Glycyrrhetinic acid (GA) is known to have multiple beneficial effects, including antioxidant activity; however, the underlying molecular mechanisms have not been well established
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Biochelates from Spent Coffee Grounds Increases Iron Levels in Dutch Cucumbers but Affects Their Antioxidant Capacity Antioxidants (IF 7.0) Pub Date : 2024-04-15 Beatriz Navajas-Porras, Ana Cervera-Mata, Alejandro Fernández-Arteaga, Adriana Delgado-Osorio, Miguel Navarro-Moreno, Daniel Hinojosa-Nogueira, Silvia Pastoriza, Gabriel Delgado, Miguel Navarro-Alarcón, José Ángel Rufián-Henares
Spent coffee grounds (SCG) are a type of food waste and are produced in abundance around the world. However, their utilization as a soil organic amendment is challenging due to their phytotoxic effect. In the present work, the impact of agronomic biofortification on Dutch cucumbers was investigated using different chemically modified SCG and analyzing their effects on iron contents, their capacity
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Profile of Bioactive Components and Antioxidant Activity of Aronia melanocarpa Fruits at Various Stages of Their Growth, Using Chemometric Methods Antioxidants (IF 7.0) Pub Date : 2024-04-14 Natalia Dobros, Agnieszka Zielińska, Paweł Siudem, Katarzyna Dorota Zawada, Katarzyna Paradowska
Aronia (chokeberry, Aronia melanocarpa) is a valuable fruit that combines the health benefits of green tea and red wine and is gaining popularity worldwide. Aronia has a unique chemical composition with strong antioxidant properties, including anthocyanins and chlorogenic acids (CGAs). However, it remains unclear which specific compounds or groups are primarily responsible for the antioxidant properties
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Multivariate Analysis of Biochemical Properties Reveals Diversity among Yardlong Beans of Different Origins Antioxidants (IF 7.0) Pub Date : 2024-04-14 Yu-Mi Choi, Hyemyeong Yoon, Myoung-Jae Shin, Sukyeung Lee, Jungyoon Yi, Young-ah Jeon, Xiaohan Wang, Kebede Taye Desta
This study analyzed the nutrient levels, secondary metabolite contents, and antioxidant activities of 35 yardlong bean accessions from China, Korea, Myanmar, and Thailand, along with their key agronomic traits. Significant variations were found in all the parameters analyzed (p < 0.05). The crude fiber (CFC), dietary fiber (DFC), total protein, and total fat contents varied from 4.10 to 6.51%, 16.71
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Antioxidant Systematic Alteration Was Responsible for Injuries Inflicted on the Marine Blue Mussel Mytilus edulis Following Strontium Exposure Antioxidants (IF 7.0) Pub Date : 2024-04-14 Zihua Cheng, Mengxue Xu, Qiyue Cao, Wendan Chi, Sai Cao, Zhongyuan Zhou, You Wang
The ionic properties of strontium (Sr), a significant artificial radionuclide in the marine environment, were estimated using a stable nuclide-substituting experimental system under controlled laboratory conditions. The bio-accumulation of Sr and its impacts, as well as any possible hidden mechanisms, were evaluated based on the physiological alterations of the sentinel blue mussel Mytilus edulis.
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Εleven Greek Legume Beans: Assessment of Genotypic Effect on Their Phytochemical Content and Antioxidant Properties Antioxidants (IF 7.0) Pub Date : 2024-04-13 Eleni D. Myrtsi, Dimitrios N. Vlachostergios, Christos Petsoulas, Sofia D. Koulocheri, Epameinondas Evergetis, Serkos A. Haroutounian
Legumes, one of the first crops of humanity, inherently constitute a staple nutritional source for mankind, attracting significant research attention that has been afforded to the development of numerous cultivars. The study herein concerns the exploitation of the nutritional and bio-functional content of beans harvested from eleven Greek cultivars belonging to five different species, namely Cicer
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The Neuroprotective Flavonoids Sterubin and Fisetin Maintain Mitochondrial Health under Oxytotic/Ferroptotic Stress and Improve Bioenergetic Efficiency in HT22 Neuronal Cells Antioxidants (IF 7.0) Pub Date : 2024-04-13 Marie Goujon, Zhibin Liang, David Soriano-Castell, Antonio Currais, Pamela Maher
The global increase in the aging population has led to a rise in many age-related diseases with continuing unmet therapeutic needs. Research into the molecular mechanisms underlying both aging and neurodegeneration has identified promising therapeutic targets, such as the oxytosis/ferroptosis cell death pathway, in which mitochondrial dysfunction plays a critical role. This study focused on sterubin
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Oxidative Stress and Chronic Myeloid Leukemia: A Balance between ROS-Mediated Pro- and Anti-Apoptotic Effects of Tyrosine Kinase Inhibitors Antioxidants (IF 7.0) Pub Date : 2024-04-13 Alessandro Allegra, Giuseppe Mirabile, Santino Caserta, Fabio Stagno, Sabina Russo, Giovanni Pioggia, Sebastiano Gangemi
The balanced reciprocal translocation t (9; 22) (q34; q11) and the BCR-ABL fusion gene, which produce p210 bcr-abl protein production with high tyrosine kinase activity, are characteristics of chronic myeloid leukemia, a myeloproliferative neoplasm. This aberrant protein affects several signaling pathways connected to both apoptosis and cell proliferation. It has been demonstrated that tyrosine kinase
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Nrf2 Plays a Key Role in Erythropoiesis during Aging Antioxidants (IF 7.0) Pub Date : 2024-04-12 Serge Cedrick Toya Mbiandjeu, Angela Siciliano, Alessandro Mattè, Enrica Federti, Massimiliano Perduca, Davide Melisi, Immacolata Andolfo, Angela Amoresano, Achille Iolascon, Maria Teresa Valenti, Francesco Turrini, Michele Bovi, Arianna Pisani, Antonio Recchiuti, Domenico Mattoscio, Veronica Riccardi, Luca Dalle Carbonare, Carlo Brugnara, Narla Mohandas, Lucia De Franceschi
Aging is characterized by increased oxidation and reduced efficiency of cytoprotective mechanisms. Nuclear factor erythroid-2-related factor (Nrf2) is a key transcription factor, controlling the expression of multiple antioxidant proteins. Here, we show that Nrf2−/− mice displayed an age-dependent anemia, due to the combined contributions of reduced red cell lifespan and ineffective erythropoiesis
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Oxidative Stress: A Culprit in the Progression of Diabetic Kidney Disease Antioxidants (IF 7.0) Pub Date : 2024-04-12 Na Wang, Chun Zhang
Diabetic kidney disease (DKD) is the principal culprit behind chronic kidney disease (CKD), ultimately developing end-stage renal disease (ESRD) and necessitating costly dialysis or kidney transplantation. The limited therapeutic efficiency among individuals with DKD is a result of our finite understanding of its pathogenesis. DKD is the result of complex interactions between various factors. Oxidative
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Unravelling the Influence of Chlorogenic Acid on the Antioxidant Phytochemistry of Avocado (Persea americana Mill) Fruit Peel Antioxidants (IF 7.0) Pub Date : 2024-04-12 Gloria O. Izu, Emmanuel Mfotie Njoya, Gaetan T. Tabakam, Jennifer Nambooze, Kgalaletso P. Otukile, Seiso E. Tsoeu, Victoria O. Fasiku, Ayodeji M. Adegoke, Ochuko L. Erukainure, Samson S. Mashele, Tshepiso J. Makhafola, Mamello P. Sekhoacha, Chika I. Chukwuma
Oxidative stress is pivotal in the pathology of many diseases. This study investigated the antioxidant phytochemistry of avocado (Persea americana Mill) peel. Different solvent extracts (dichloromethane, ethyl acetate, methanol, and water) of avocado peel were subjected to total phenol and flavonoid quantification, as well as in vitro radical scavenging and ferric reducing evaluation. The methanol
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Obesity Is Associated with Oxidative Stress Markers and Antioxidant Enzyme Activity in Mexican Children Antioxidants (IF 7.0) Pub Date : 2024-04-12 Ana Isabel Cota-Magaña, Miguel Vazquez-Moreno, Andrés Rocha-Aguado, Selene Ángeles-Mejía, Adán Valladares-Salgado, Margarita Díaz-Flores, Norma Edith López-Díazguerrero, Miguel Cruz
The relationship between metabolic disorders and oxidative stress is still controversial in the child population. The present cross-sectional study aimed to analyze the associations between obesity, cardiometabolic traits, serum level of carbonylated proteins (CPs), malondialdehyde (MDA), and the enzyme activity of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in children
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Effects of Phytosterol Ester Supplementation on Egg Characteristics, Eggshell Ultrastructure, Antioxidant Capacity, Liver Function and Hepatic Metabolites of Laying Hens during Peak Laying Period Antioxidants (IF 7.0) Pub Date : 2024-04-12 Wenzi Wu, Xin Ma, Rui Chen, Jinghui Fan, Wenxin Ye, Zhuo Chen, Qixin Huang, Lichun Qian
The aim of this experiment was to investigate the effects of dietary Phytosterol Ester (PSE) supplementation on egg characteristics, eggshell ultrastructure, antioxidant capacity, liver function, hepatic metabolites, and its mechanism of action in Hy-Line Brown laying hens during peak laying period. A total of 256 healthy Hy-Line Brown laying hens were randomly allocated into four groups. The hens
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Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway Antioxidants (IF 7.0) Pub Date : 2024-04-10 Minghui Dong, Ziying Yang, Qian Gao, Qingyuan Deng, Le Li, Hongmei Chen
2,2′,4,4′-Tetrabrominated biphenyl ether (BDE-47) is a polybrominated diphenyl ether (PBDE) homologue that is ubiquitous in biological samples and highly toxic to humans and other organisms. Prior research has confirmed that BDE-47 can induce oxidative damage in RAW264.7 cells, resulting in apoptosis and impaired immune function. The current study mainly focused on how Isoliquiritigenin (ISL) and Licochalcone
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Effects of Regular Exercise on the Biochemical, Oxidative, and Inflammatory Profiles and Quality of Life in Older Spaniards with Metabolic Syndrome Antioxidants (IF 7.0) Pub Date : 2024-04-11 Margalida Monserrat-Mesquida, Maria Magdalena Quetglas-Llabrés, Cristina Bouzas, Silvia García, David Mateos, Lucía Ugarriza, Cristina Gómez, Josep A. Tur, Antoni Sureda
Metabolic syndrome increases the risk of developing diabetes and cardiovascular disease. The regular practice of physical activity is a crucial factor for healthy aging and for controlling and preventing chronic diseases. To assess the effects of regular physical activity on the biochemical and inflammatory profiles, as well as the quality of life of older adults diagnosed with metabolic syndrome.
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circAMN1-Mediated Ferroptosis Regulates the Expulsion of Placenta in Trophoblast Cells Antioxidants (IF 7.0) Pub Date : 2024-04-11 Chen Lv, Lusha Guo, Yue Wang, Zongshuai Li, Xingxu Zhao, Yong Zhang
After delivery, the death of trophoblast cells can promote the expulsion of the placenta. Ferroptosis, an iron-dependent programmed cell death, is involved in mammalian development. Circular RNAs are associated with placental development; however, it is unclear whether circular RNAs regulate the expulsion of fetal membranes through ferroptosis. The gene expression profiles in the tail vein blood of
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Lycopene as a Therapeutic Agent against Aflatoxin B1-Related Toxicity: Mechanistic Insights and Future Directions Antioxidants (IF 7.0) Pub Date : 2024-04-11 Meng Li, Shusheng Tang, Xinyan Peng, Gaurav Sharma, Shutao Yin, Zhihui Hao, Jichang Li, Jianzhong Shen, Chongshan Dai
Aflatoxin (AFT) contamination poses a significant global public health and safety concern, prompting widespread apprehension. Of the various AFTs, aflatoxin B1 (AFB1) stands out for its pronounced toxicity and its association with a spectrum of chronic ailments, including cardiovascular disease, neurodegenerative disorders, and cancer. Lycopene, a lipid-soluble natural carotenoid, has emerged as a
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Impact of Maternal Environment and Inflammation on Fetal Neurodevelopment Antioxidants (IF 7.0) Pub Date : 2024-04-11 Chiara Lubrano, Francesca Parisi, Irene Cetin
During intrauterine life, external stimuli including maternal nutrition, lifestyle, socioeconomic conditions, anxiety, stress, and air pollution can significantly impact fetal development. The human brain structures begin to form in the early weeks of gestation and continue to grow and mature throughout pregnancy. This review aims to assess, based on the latest research, the impact of environmental
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A Physiological Approach to Explore How Thioredoxin–Glutathione Reductase (TGR) and Peroxiredoxin (Prx) Eliminate H2O2 in Cysticerci of Taenia Antioxidants (IF 7.0) Pub Date : 2024-04-10 Alberto Guevara-Flores, Gabriela Nava-Balderas, José de Jesús Martínez-González, César Vásquez-Lima, Juan Luis Rendón, Irene Patricia del Arenal Mena
Peroxiredoxins (Prxs) and glutathione peroxidases (GPxs) are the main enzymes of the thiol-dependent antioxidant systems responsible for reducing the H2O2 produced via aerobic metabolism or parasitic organisms by the host organism. These antioxidant systems maintain a proper redox state in cells. The cysticerci of Taenia crassiceps tolerate millimolar concentrations of this oxidant. To understand the
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Oxidative Stress and Antioxidant Status in Adult Patients with Transfusion-Dependent Thalassemia: Correlation with Demographic, Laboratory, and Clinical Biomarkers Antioxidants (IF 7.0) Pub Date : 2024-04-10 Antonella Meloni, Laura Pistoia, Anna Spasiano, Antonella Cossu, Tommaso Casini, Antonella Massa, Sergio Bagnato, Maria Caterina Putti, Silvia Maffei, Vincenzo Positano, Alessia Pepe, Filippo Cademartiri, Cristina Vassalle
Iron overload in beta transfusion-dependent thalassemia (β-TDT) may provoke oxidative stress and reduction of the antioxidant defenses, with serious consequences for the disease course and complications. The present study evaluated the oxidant/antioxidant status of β-TDT patients and its correlation with demographic, clinical, laboratory, and instrumental biomarkers. The OXY-adsorbent assay and the
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Higher Intensity of Salt Stress Accompanied by Heat Inhibits Stomatal Conductance and Induces ROS Accumulation in Tomato Plants Antioxidants (IF 7.0) Pub Date : 2024-04-10 Yankai Li, Fangling Jiang, Zhenxiang He, Yi Liu, Zheng Chen, Carl-Otto Ottosen, Ron Mittler, Zhen Wu, Rong Zhou
Under natural conditions, abiotic stresses that limit plant growth and development tend to occur simultaneously, rather than individually. Due to global warming and climate change, the frequency and intensity of heat and salt stresses are becoming more frequent. Our aim is to determine the response mechanisms of tomato to different intensities of combined heat and salt stresses. The physiological and
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Synergistic Antioxidant and Anti-Inflammatory Effects of Phenolic Acid-Conjugated Glutamine–Histidine–Glycine–Valine (QHGV)Peptides Derived from Oysters (Crassostrea talienwhanensis) Antioxidants (IF 7.0) Pub Date : 2024-04-10 Soyun Choi, Sohee Han, Seungmi Lee, Jongmin Kim, Jinho Kim, Dong-Ku Kang
The glutamine–histidine–glycine–valine (QHGV), a peptide derived from oysters, exhibits antioxidant activity and is being actively researched as a potential pharmaceutical and functional cosmetic ingredient. In this study, we synthesized the QHGV peptide and explored the hitherto unknown anti-inflammatory effects of QHGV. The antioxidant property was also characterized by conjugating with various naturally
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Unveiling the Significance of Peroxiredoxin 6 in Central Nervous System Disorders Antioxidants (IF 7.0) Pub Date : 2024-04-10 Min Xue, Xiaojie Huang, Tong Zhu, Lijun Zhang, Hao Yang, Yuxian Shen, Lijie Feng
Peroxiredoxin 6 (Prdx6), a unique 1-Cys member of the peroxiredoxin family, exhibits peroxidase activity, phospholipase activity, and lysophosphatidylcholine acyltransferase (LPCAT) activity. Prdx6 has been known to be an important enzyme for the maintenance of lipid peroxidation repair, cellular metabolism, inflammatory signaling, and antioxidant damage. Growing research has demonstrated that the
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α-Phenyl-N-tert-Butylnitrone and Analogous α-Aryl-N-alkylnitrones as Neuroprotective Antioxidant Agents for Stroke Antioxidants (IF 7.0) Pub Date : 2024-04-07 José Marco-Contelles
The recent advances in research on the use of the antioxidant and neuroprotective agent α-phenyl-N-tert-butylnitrone (PBN) for the therapy of stroke have been reviewed. The protective effect of PBN in the transient occlusion of the middle cerebral artery (MCAO) has been demonstrated, although there have been significant differences in the neuronal salvaging effect between PBN-treated and untreated
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Dose-Dependent Effects of Lipopolysaccharide on the Endothelium—Sepsis versus Metabolic Endotoxemia-Induced Cellular Senescence Antioxidants (IF 7.0) Pub Date : 2024-04-09 Dennis Merk, Fiona Frederike Cox, Philipp Jakobs, Simone Prömel, Joachim Altschmied, Judith Haendeler
The endothelium, the innermost cell layer of blood vessels, is not only a physical barrier between the bloodstream and the surrounding tissues but has also essential functions in vascular homeostasis. Therefore, it is not surprising that endothelial dysfunction is associated with most cardiovascular diseases. The functionality of the endothelium is compromised by endotoxemia, the presence of bacterial
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Novel Antioxidants for Animal Nutrition Antioxidants (IF 7.0) Pub Date : 2024-04-07 Luciana Rossi, Matteo Dell’Anno
In recent years, the importance of nutrition has notably escalated, with antioxidants emerging as crucial ingredients in the formulation of functional diets pivotal for promoting animal health and preventing diseases [...]
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Antioxidant Actions of Melatonin: A Systematic Review of Animal Studies Antioxidants (IF 7.0) Pub Date : 2024-04-07 Karla Krislane Alves Costa Monteiro, Marcos Eiji Shiroma, Luciana Lamarão Damous, Manuel de Jesus Simões, Ricardo dos Santos Simões, José Cipolla-Neto, Edmund Chada Baracat, Jose Maria Soares-Jr.
Melatonin is an indoleamine with crucial antioxidant properties that are used to combat inflammatory and neoplastic processes, as well as control transplants. However, the clinical applications of melatonin have not yet been fully consolidated in the literature and require in-depth analysis. Objectives: This study reviewed the literature on the antioxidant properties of melatonin in rat models. Methods:
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Cordyceps militaris Extract and Cordycepin Alleviate Oxidative Stress, Modulate Gut Microbiota and Ameliorate Intestinal Damage in LPS-Induced Piglets Antioxidants (IF 7.0) Pub Date : 2024-04-08 Shijie Xiong, Jiajia Jiang, Fan Wan, Ding Tan, Haibo Zheng, Huiqin Xue, Yiqiong Hang, Yang Lu, Yong Su
Cordycepin is considered a major bioactive component in Cordyceps militaris extract. This study was performed to evaluate the ameliorative effect of Cordyceps militaris extract (CME) and cordycepin (CPN) supplementation on intestinal damage in LPS-challenged piglets. The results showed that CPN or CME supplementation significantly increased the villus height (p < 0.01) and villus height/crypt depth
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Glutathione S-Transferase Genes Involved in Response to Short-Term Heat Stress in Tetranychus urticae (Koch) Antioxidants (IF 7.0) Pub Date : 2024-04-08 Tong Zhu, Bin Wei, Yue Wang, Suqin Shang
Tetranychus urticae, a globally ubiquitous mite, poses a significant threat to agriculture. Elevated temperatures exacerbate the growth, development, and reproduction of T. urticae, leading to substantial crop damage. In this study, we employed comparative transcriptomic approaches with whole-genome information of T. urticae to identify six Glutathione S-transferase genes (GSTs) implicated in heat
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Suitable Cottonseed Protein Concentrate Supplementation in Common Carp (Cyprinus carpio) Serves as an Effective Strategy for Fish Meal Sparing Based on Improvement in Intestinal Antioxidant Capacity, Barrier and Microbiota Composition Antioxidants (IF 7.0) Pub Date : 2024-04-04 Ze Fan, Kaibo Ge, Di Wu, Liansheng Wang, Jinnan Li, Chenhui Li, Meng Zhou, Haitao Zhang, Linghong Miao, Xianping Ge
The application of cottonseed protein concentrate (CPC) is an effective strategy to moderate the shortage of fish meal (FM) for the aquafeed industry. However, little attention has been paid to the effects of replacing fishmeal with CPC on cyprinid fish. This study used common carp (Cyprinus carpio) as the biological model and assessed the potential of applying CPC as a substitute for fishmeal in the
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Harmony in Motion: Unraveling the Nexus of Sports, Plant-Based Nutrition, and Antioxidants for Peak Performance Antioxidants (IF 7.0) Pub Date : 2024-04-04 Asma Ayaz, Wajid Zaman, Zsolt Radák, Yaodong Gu
The intricate interplay between plant-based nutrition, antioxidants, and their impact on athletic performance forms the cornerstone of this comprehensive review. Emphasizing the pivotal importance of dietary choices in the realm of sports, this paper sets the stage for an in-depth exploration of how stress and physical performance are interconnected through the lens of nutrition. The increasing interest
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Euonymus alatus Leaf Extract Attenuates Effects of Aging on Oxidative Stress, Neuroinflammation, and Cognitive Impairment Antioxidants (IF 7.0) Pub Date : 2024-04-02 Pallavi Gurung, Junmo Lim, Til Bahadur Thapa Magar, Rajeev Shrestha, Yong-Wan Kim
Our study aimed to explore the impact and mechanism of Euonymus alatus leaf extract on age-dependent oxidative stress, neuroinflammation, and progressive memory impairments in aged mice. Twenty-four-month-old mice received EA-L3 (300 mg/kg/day) or the reference drug, donepezil (DPZ, 5 mg/kg/day), for 6 weeks, and learning and memory functions were detected using the Passive Avoidance Test (PAT). As
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Redox Regulation of Mitochondrial Potassium Channels Activity Antioxidants (IF 7.0) Pub Date : 2024-04-03 Joanna Lewandowska, Barbara Kalenik, Antoni Wrzosek, Adam Szewczyk
Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (ROS) by mitochondria, (2) the presence of a substantial array of redox enzymes such as respiratory chain, and (3) the responsiveness of mitochondria
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Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer’s Disease Antioxidants (IF 7.0) Pub Date : 2024-04-03 Erica Staurenghi, Gabriella Testa, Valerio Leoni, Rebecca Cecci, Lucrezia Floro, Serena Giannelli, Eugenio Barone, Marzia Perluigi, Gabriella Leonarduzzi, Barbara Sottero, Paola Gamba
Down syndrome (DS) is a complex chromosomal disorder considered as a genetically determined form of Alzheimer’s disease (AD). Maintenance of brain cholesterol homeostasis is essential for brain functioning and development, and its dysregulation is associated with AD neuroinflammation and oxidative damage. Brain cholesterol imbalances also likely occur in DS, concurring with the precocious AD-like neurodegeneration
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A Mechanistic Study of the Osteogenic Effect of Arecoline in an Osteoporosis Model: Inhibition of Iron Overload-Induced Osteogenesis by Promoting Heme Oxygenase-1 Expression Antioxidants (IF 7.0) Pub Date : 2024-03-31 Zhongjing Jiang, Linhua Deng, Gang Xiang, Xia Xu, Yunjia Wang
Iron overload-associated osteoporosis presents a significant challenge to bone health. This study examines the effects of arecoline (ACL), an alkaloid found in areca nut, on bone metabolism under iron overload conditions induced by ferric ammonium citrate (FAC) treatment. The results indicate that ACL mitigates the FAC-induced inhibition of osteogenesis in zebrafish larvae, as demonstrated by increased
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Development and Characterization of Modified Gelatin-Based Cling Films with Antimicrobial and Antioxidant Activities and Their Application in the Preservation of Cherry Tomatoes Antioxidants (IF 7.0) Pub Date : 2024-04-02 Jianfu Qiao, Linjing Wang, Luxin Wang, Ziyan Li, Yue Huai, Shaoying Zhang, Youwei Yu
The utilization of functional cling films presents a promising approach to alleviate post-harvest spoilage caused by microbial activity, oxidative metabolism, and moisture loss in agricultural products. To overcome the environmental problems of conventional packaging materials, in this study, we developed functional fruit and vegetable cling films based on glycidyltrimethylammonium chloride and rosemarinic
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Nitrosative Stress in Astronaut Skeletal Muscle in Spaceflight Antioxidants (IF 7.0) Pub Date : 2024-04-02 Dieter Blottner, Manuela Moriggi, Gabor Trautmann, Sandra Furlan, Katharina Block, Martina Gutsmann, Enrica Torretta, Pietro Barbacini, Daniele Capitanio, Joern Rittweger, Ulrich Limper, Pompeo Volpe, Cecilia Gelfi, Michele Salanova
Long-duration mission (LDM) astronauts from the International Space Station (ISS) (>180 ISS days) revealed a close-to-normal sarcolemmal nitric oxide synthase type-1 (NOS1) immunoexpression in myofibers together with biochemical and quantitative qPCR changes in deep calf soleus muscle. Nitro-DIGE analyses identified functional proteins (structural, metabolic, mitochondrial) that were over-nitrosylated
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Oral Curcumin–Thioketal–Inulin Conjugate Micelles against Radiation–Induced Enteritis Antioxidants (IF 7.0) Pub Date : 2024-03-29 Jintao Shen, Wencheng Jiao, Bochuan Yuan, Hua Xie, Ziyuan Chen, Meng Wei, Yingbao Sun, Yanping Wu, Feng Zhang, Zhangyu Li, Xu Jin, Lina Du, Yiguang Jin
Radiation–induced enteritis is an unavoidable complication associated with pelvic tumor radiotherapy, significantly influencing the prognosis of cancer patients. The limited availability of commercial gastrointestinal radioprotectors in clinical settings poses a substantial challenge in preventing radiation enteritis. Despite the inherent radioprotective characteristics of Cur in vitro, its poor solubility
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Dietary Polyphenols: Review on Chemistry/Sources, Bioavailability/Metabolism, Antioxidant Effects, and Their Role in Disease Management Antioxidants (IF 7.0) Pub Date : 2024-03-30 Mithun Rudrapal, Gourav Rakshit, Ravi Pratap Singh, Samiksha Garse, Johra Khan, Soumi Chakraborty
Polyphenols, as secondary metabolites ubiquitous in plant sources, have emerged as pivotal bioactive compounds with far-reaching implications for human health. Plant polyphenols exhibit direct or indirect associations with biomolecules capable of modulating diverse physiological pathways. Due to their inherent abundance and structural diversity, polyphenols have garnered substantial attention from
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Fucoidan Supplementation Improves Antioxidant Capacity via Regulating the Keap1/Nrf2 Signaling Pathway and Mitochondrial Function in Low-Weaning Weight Piglets Antioxidants (IF 7.0) Pub Date : 2024-03-28 Chenggang Yin, Qingyue Bi, Wenning Chen, Chengwei Wang, Bianca Castiglioni, Yanpin Li, Wenjuan Sun, Yu Pi, Valentino Bontempo, Xilong Li, Xianren Jiang
Fucoidan (FC) is known for its antioxidant properties, but it has unclear effects and mechanisms on weaned piglets. Two experiments were conducted to determine the optimal FC dosage in piglet diets and its protective effect against lipopolysaccharide (LPS)-induced oxidative stress. In experiment one, 24 low weight weaned piglets were randomly assigned to four dietary treatments: a basal diet (FC 0)
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Loranthus tanakae Franch. and Sav. Attenuates Respiratory Inflammation Caused by Asian Sand Dust Antioxidants (IF 7.0) Pub Date : 2024-03-29 Se-Jin Lee, So-Won Pak, A Yeong Lee, Woong-Il Kim, Sung-Wook Chae, Young-Kwon Cho, Je-Won Ko, Tae-Won Kim, Jong-Choon Kim, Byeong Cheol Moon, Yun-Soo Seo, In-Sik Shin
Asian sand dust (ASD), generally produced in East Asia, including China, Japan, and Korea, directly leads to the development of pulmonary disease and exacerbates underlying pulmonary diseases. Loranthus tanakae Franch. and Sav. is a traditional herbal medicine applied to improve various inflammatory conditions. Here, we evaluated the curative properties of L. tanakae ethanol extract (LTE) against pulmonary