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GCMS-based phytochemical profiling and in vitro pharmacological activities of plant Alangium salviifolium (L.f) Wang Future J. Pharm. Sci. Pub Date : 2024-04-12 Annapurneshwari M. Hongal, Arun K. Shettar, Joy H. Hoskeri, A. B. Vedamurthy
There is an urge for traditional herbal remedies as an alternative to modern medicine in treating several diseases. A significant number of modern pharmaceutical drugs are based on or derived from medicinal plants or their extracts. These drugs derived from the plant origin have various antimicrobial, antioxidant, anticancer, anti-inflammatory activities. Alangium salviifolium belongs to Cornaceae
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Unveiling geniposide from Paederia foetida as a potential antihypertensive treatment: an integrated approach involving in vivo and computational methods Future J. Pharm. Sci. Pub Date : 2024-04-09 Chanchal Koley, Arijit Mondal, Suddhsattya Dey, Ravi Rawat, Anjan Mondal, Naresh Kumar Rangra, Deeparani Urolagin, Padmacharan Behera, Dibya Lochan Mohanty, Ameeduzzafar Zafar, Volkan Eyupoglu
Hypertension is one of the burning topics in today’s world. Natural product can open a new window in the treatment as they are lesser side effect compared to synthetic compounds. Paederia foetida a naturally occurring plant has proven its biological importance in many aspects. In this present study, the ethanolic extract of Paederia foetida has effectively proven its antihypertensive activity against
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Investigation of the antidiabetic and probiotic properties of lactic acid bacteria isolated from some ethnic fermented foods of Darjeeling District Future J. Pharm. Sci. Pub Date : 2024-04-08 Amlan Jyoti Ghosh, Supriyo Ghosh, Manab Deb Adhikari, Tilak Saha
Indigenous communities residing in the Darjeeling Himalayan region and its adjacent hilly areas have a deeply rooted cultural tradition of consuming a diverse range of vegetable and milk-based fermented products, believed to confer various health advantages. With this traditional knowledge, lactic acid bacteria (LAB) were isolated from popular fermented foods such as Chhurpi (derived from Bos grunniens
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Evaluating the effect of artificial intelligence on pharmaceutical product and drug discovery in China Future J. Pharm. Sci. Pub Date : 2024-04-08 Agyemang Kwasi Sampene, Fatuma Nyirenda
The pharmaceutical sector has recently witnessed a transformative improvement and shift toward artificial intelligence (AI) in its drug and pharmaceutical delivery process and procedures. Hence, this research delves into the benefits and obstacles pharmaceutical firms face in utilizing AI in China. Globally, China is recognized as a dominant pillar in research and development in the pharmaceutical
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Bioanalytical method development and validation for quantification of amivantamab in rat plasma by LC-MS/MS Future J. Pharm. Sci. Pub Date : 2024-04-05 Pridhvi Krishna Gaddey, Raja Sundararajan
Amivantamab is a monoclonal bispecific anti-EGFR-MET antibody used to treat non-small cell lung cancer. There were no published methods using a liquid chromatographic—tandem mass spectrometric approach to develop and validate a feasible, novel, and thoroughly validated method for quantifying amivantamab in rat plasma. The liquid–liquid extraction method was used to extract the analyte from rat plasma
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nCoV-19 therapeutics using cucurbitacin I structural derivatives: an in silico approach Future J. Pharm. Sci. Pub Date : 2024-04-04 Ram Lal Swagat Shrestha, Bishnu Prasad Marasini, Jhashanath Adhikari Subin
Cucurbitacins are present in some common vegetables as secondary metabolites and are used by the plants against harmful microbes. Exploration of this capability of natural product based substances against wide variety of microbes seems relevant due to the ease of availability of the resources and safety. In this regard, considering the current pandemic, the antiviral properties of these molecules with
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Natural product-inspired strategies towards the discovery of novel bioactive molecules Future J. Pharm. Sci. Pub Date : 2024-04-02 Sunita Gagare, Pranita Patil, Ashish Jain
The intricate molecular frameworks of natural products with biological activity towards human targets offer academic and industrial chemists an important starting point for next generation drug discovery. With a focus on natural products for the production of diverse small-molecule libraries and the evaluation of uncharted chemical space, several strategies have emerged for achieving selective modulation
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Development of docetaxel-loaded (Soluplus®–PF108) mixed micelles vacuum foam-dried product for improved stability and melanoma treatment by QbD approach Future J. Pharm. Sci. Pub Date : 2024-04-02 Rutuja Chougale, Kiran Patil, John Disouza, Ashok Hajare, Namdeo Jadhav, Popat Kumbhar
Docetaxel (DTX) finds extensive use in treating various cancers, but its limited solubility, side effects, and multi-drug resistance (MDR) hinder its effectiveness. To enhance DTX's properties, the study aimed to formulate DTX-loaded mixed micelles (MMs) and evaluate their anticancer potential using Quality by Design (QbD) approach. Using solvent evaporation, DTX-loaded MMs were prepared and optimized
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Influence of artificial intelligence in modern pharmaceutical formulation and drug development Future J. Pharm. Sci. Pub Date : 2024-03-29 Kazi Asraf Ali, SK Mohin, Puja Mondal, Susmita Goswami, Soumya Ghosh, Sabyasachi Choudhuri
Artificial intelligence (AI) revolutionized the formulation and development of modern pharmaceuticals. With the help of AI, researchers can now optimize drug design, develop formulations, and streamline clinical trials in a much accurate and efficient way. Drug development might be greatly expedited and time-consuming procedure; however, with the help of AI this are significantly reduced. The main
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Antiproliferative effect of Saraca asoca methanol bark extract on triple negative breast cancer (TNBC) Future J. Pharm. Sci. Pub Date : 2024-03-29 Chennattu M. Pareeth, K. P. Safna Hussan, Davis Anu, Nair Meera, Deepu Mathew, Ravishankar Valsalan, Mohamed Shahin Thayyil, Kannoor M. Thara, Achuthan C. Raghavamenon, Thekkekara D. Babu
Saraca asoca (Asoka) is reported to possess phytoestrogenic components with anticancer properties. The phytoestrogens are recognized as natural agonists for ERβ, which acts as an antagonist to ERα. Despite the absence of ERα, studies have identified ERβ in 50–80% of triple negative breast cancers (TNBC). Thus, the present study is intended to reveal the role of phytoestrogens of Asoka on TNBC. The
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Design, synthesis, and evaluation of anxiolytic activity of 2-(4-phenylpiperazin-1-yl)-1H-benz[d]imidazole and 2-(4-phenylpiperazin-1-methyl)-1H-benz[d]imidazole derivatives Future J. Pharm. Sci. Pub Date : 2024-03-29 Bhavna Sunil Mahajan, Laxman A. Kawale, Vandana S. Nade, Supriya Unavane, Lida Sajimon, Prajakta Kapadnis
In contemporary society, anxiety has become a widespread disorder leading to compromised well-being and heightened depressive states. Extensive literature reviews indicate the diverse biological effects of benzimidazole and piperazine derivatives, notably their impact on the central nervous system. This study aimed to design, molecularly dock, synthesize, and assess the anxiolytic potential of six
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Chemical composition and antifungal activity of Teucrium Leucocladum Boiss. essential oils growing in Egypt using two different techniques Future J. Pharm. Sci. Pub Date : 2024-03-28 Eman Mohamed Salah, Marwa Y. Issa, Tarik A. Mohamed, Mohamed-Elamir F. Hegazy, Soad H. Tadros, Noha Fathallah
Teucrium Leucocladum Boiss. (TL) (family Lamiaceae), indigenous to Sinai, Egypt, and Mediterranean region, is considered a rich source of essential oils (EOs). This study aimed to extract the aerial parts essential oils utilizing hydro-distillation (HD) and microwave-assisted extraction (MAE), and analyze the volatile constituents by Gas Chromatography–Mass Spectrometry (GC/MS). The antifungal and
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Phytochemical screening, gas chromatograph/mass spectrometer (GCMS) analysis and molecular toxicological potential of Hunteria umbellata aqueous fruit extract against Staphylococcus aureus in accessory gene regulators (AGRs) Future J. Pharm. Sci. Pub Date : 2024-03-28 Titilola Fausat Salisu, Muinah Adenike Fowora, Tajudeen Olanrewaju Yahaya, Sulaimon Adebisi Aina, Benjamin Thoha Thomas, Latifat Aderonke Ademola, Precious Oluwabukola Jimoh
Fruits of Hunteria umbellata (HU) have been utilized in folk medicine as potent against Staphylococcus aureus (SA) infections, particularly skin and nasal related conditions. However, there is scarcity of literature concerning toxicological evaluation of graded doses of HU fruit, especially at molecular level, specifically targeting the accessory gene regulator (AGR) system to prevent abuse of doses
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Size-dependent effects of niosomes on the penetration of methotrexate in skin layers Future J. Pharm. Sci. Pub Date : 2024-03-27 Sakshi Soni, Kalpana Baghel, Murari Lal Soni, Sushil K. Kashaw, Vandana Soni
Niosomes hold promise as drug delivery systems for cancer treatment, with niosome size impacting stability, biodistribution, and effectiveness. This study optimized methotrexate (MTX)-loaded niosome formulation by studying the effects of components and processing conditions on size. The niosomes formulation was made by the thin-film hydration technique. The optimized formulation (NIO 17) with a 6:2:2
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Captopril pretreatment augments diabetogenic response to streptozotocin administration: experimental in vivo rat model Future J. Pharm. Sci. Pub Date : 2024-03-25 Hayam Ateyya, Asmaa Mohammed ShamsEldeen, Sara Adel Hosny, Samaa Samir Kamar, Laila Ahmed Rashed, Abeer Mostafa, Inas Harb
Streptozotocin (STZ) is a glucose analogue commonly used for inducing diabetes in experimental animals. This study is intended to investigate the ability of captopril (Cap) pretreatment to augment STZ-induced diabetogenic effect in an experimental rat model. If this hypothesis were proven, Cap administration to rats could reduce the dosage of STZ by augmenting its effect and resulting in a subsequent
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A DoE-based development and characterization of Nadifloxacin-loaded transethosomal gel for the treatment of Acne vulgaris Future J. Pharm. Sci. Pub Date : 2024-03-19 Sujeet Patil, Panchaxari M. Dandagi, Taufik Kazi, Sujay Hulyalkar, Prakash Biradar, Vijay Kumbar
The objective of this current research was to enhance the topical delivery of Nadifloxacin (NDFX) by incorporating it into a transethosomal gel formulation. NDFX has limited penetration into the deep layer of the skin because it is poorly water soluble and it has a log p value of 2.47. To optimize the formulation, the “Box–Behnken design” was utilized. The independent variables included phosphatidylcholine
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Design, synthesis, 2D-QSAR, molecular dynamic simulation, and biological evaluation of topiramate–phenolic acid conjugates as PPARγ inhibitors Future J. Pharm. Sci. Pub Date : 2024-03-18 Ipsa Padhy, Biswajit Banerjee, P. Ganga Raju Achary, Pramodkumar P. Gupta, Tripti Sharma
Obesity is a precursor for many co-morbid diseases. One of the main triggering factors for obesity is the abnormal expansion of white adipose tissue characterized by high rates of genesis and differentiation of precursor cells into mature adipocytes. As a result, targeting adipogenesis and adipogenic transcription factors opens new roadmaps for developing novel antiobesity pharmacotherapies. The present
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Design of experiments and white analytical chemistry-driven green and sensitive spectrofluorimetric estimation of pregabalin in its pharmaceutical dosage forms and spiked human plasma Future J. Pharm. Sci. Pub Date : 2024-03-18 Pintu Prajapati, Veera Shakar Pulusu, Shailesh Shah
Pregabalin (PGB) is a medication with anticonvulsant, analgesic and anxiolytic properties, employed in the treatment of epilepsy, neuropathic pain, fibromyalgia, restless leg syndrome, opioid withdrawal syndrome and generalized anxiety disorder. Several spectrofluorimetric techniques have been documented for the determination of PGB in pharmaceutical dosage forms. However, these published methods typically
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Optimizing organically nano-fabricated Ni metal complexes for enhanced antioxidant and anticancer activity using response surface methodology Future J. Pharm. Sci. Pub Date : 2024-03-18 Swathi Aleti, Savita Belwal, Mukunda Vani Medala
Researchers, prompted by the toxicity and side effects associated with cisplatin, are exploring alternative approaches for developing transition metal-based anticancer agents. Employing a green biochemical approach, we transformed Nickel pyridine dicarboxylic acid compounds into the nanoscale using the aqueous extract of Macrotyloma uniflorum (horse gram). Characterization of the biosynthesized nanoparticles
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Formulation and evaluation of nanobiotherapeutics of Terminalia arjuna through plant tissue culture for atherosclerosis Future J. Pharm. Sci. Pub Date : 2024-03-18 Pradnya Pradeep Wadekar, Vijay Rajaram Salunkhe
The study seeks to investigate the therapeutic potential of Terminalia arjuna callus in addressing atherosclerosis. In order to get maximum beneficial phytoconstituents from Terminalia arjuna, it is recommended to harvest the bark from Arjuna trees that are at least 15 years old and a gap of minimum 2 years should be kept before harvesting bark from the same plant. The callus culture technique was
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Chemical characterization, safety profile and antileiomyoma effects of Tetrapleura tetraptera Taubert (Fabaceae) fruit ethanol extract in Sprague Dawley rats Future J. Pharm. Sci. Pub Date : 2024-03-15 Rose Osarieme Imade, Buniyamin Adesina Ayinde, Adaeze Phina Uchendu, Silvanus Innih, Aadam Anoghena Umar, Oghenemaro Victory Agoreyo, John Marvelous Adesina
Tetrapleura tetraptera Taubert (Fabaceae) fruits are employed by herbal practitioners in the management of uterine leiomyoma, but its usage in this regard and level of safety in chronic administration has not been sufficiently established. This study evaluated the toxicity effects of T. tetraptera ethanol fruit extract and explored its antileiomyoma effect in female Sprague Dawley (SD) rats. Sub-chronic
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Solvent fractions of Vitellaria paradoxa root extract suppress phenylhydrazine-mediated jaundice in Wistar rats Future J. Pharm. Sci. Pub Date : 2024-03-14 Daniel Abu Anyebe, Abdullahi Aliyu Turaki, Abdulrahman Bashir Yusuf, Ufuoma Bigila Shemishere, Musa Idu Okwanya, Yahaya Tajudeen
In the first few days of life, jaundice has continued to be a major health concern. It typically manifests as a yellowing of the skin, mucous membranes, and sclera as a result of bilirubin deposition from excessively high concentrations in the body. It affects 80% of preterm and 60% of term new-borns within the first seven days of life, which is of great concern. According to the World Health Organization
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Characterization of biochemical and optical properties of Nile tilapia (Oreochromis niloticus) corneal collagen Future J. Pharm. Sci. Pub Date : 2024-03-13 Hatem Hassan Abd-Elrahman, Wael Abdel-Moneim Omar, Hazem Abdallah Elnashar
Collagen extracted from fish body parts is a promising biological material. It has an important role in many pharmaceutical, medical applications and tissue engineering such as corneal regeneration and stromal replacement. The present work investigates a new trend to extract collagen from the fish cornea, as a prospected substituent of human corneal collagen by characterizing some biochemical and optical
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Dual drug-loaded cubosome nanoparticles for hepatocellular carcinoma: a design of experiment approach for optimization and in vitro evaluation Future J. Pharm. Sci. Pub Date : 2024-03-11 Poorvika Badiger, V. S. Mannur, Rahul Koli
Liver cancer, a formidable and complex disease, poses a significant global health threat, stemming from various causes, including chronic infections like hepatitis B and C, cirrhosis, and lifestyle factors. In liver cancer treatment, targeted delivery revolutionizes precision therapy, minimizing side effects by directing drugs specifically to cancer cells. This study aims to develop and statistically
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Genotype–phenotype correlation of fecal Streptococcus regulator (fsr) locus with gelatinase activity and biofilm formation intensity in clinical E. faecalis isolates Future J. Pharm. Sci. Pub Date : 2024-03-08 Khaled A. Abdelrahman, Mona T. Kashef, Ramy K. Aziz, Yomna A. Hashem
Enterococci, known for their disturbing involvement in nosocomial infections, possess a diverse set of virulence factors, regulated by multiple genes. A key virulence regulator is the fecal Streptococcus regulator (Fsr) quorum sensing system. Multiple reports describe the involvement of fsr genes in several virulence mechanisms, notably gelatinase production and biofilm formation; however, the presence
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Assessing physicians’ knowledge, attitude, and practice on anticoagulant therapy in non-valvular atrial fibrillation: Syrian insights Future J. Pharm. Sci. Pub Date : 2024-03-07 Sarya Swed, Haidara Bohsas, Hidar Alibrahim, Mohamad Nour Nasif, Yasmeen Abouainain, Nagham Jawish, Angela Ishak, Bassel Dibah, Eva Mahmoud, Suzanne Mahfoud, Bisher Sawaf, Wael Hafez, Nouran Omar El Said, Engy Ahmed Wahsh
Atrial fibrillation (AF) is the most prevalent cardiac condition linked to increased mortality due to complications such as stroke. Oral anticoagulant (OAC) is the mainstay in preventing cerebrovascular accidents in patients with AF. Recent evidence identified gaps in physician’s knowledge in diagnosing and managing patients with AF. This study aims to assess Syrian physicians’ knowledge, attitude
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A comprehensive review comparing conventional versus traditional remedies in the treatment of endometriosis with futuristic insights Future J. Pharm. Sci. Pub Date : 2024-03-05 Mansi Shah, Bhavarth Dave, Shivam Bhagat, Hetansh Rao, Avinash Khadela, Nisha Parikh
A common condition known as endometriosis typically takes place in females in their reproductive age and develops generally in the endometrial lining of females. Chronically, endometriosis has been associated with a reduction in the patient’s quality of life (QOL) which can have a hazardous impact on their social working and functionality. Owing to the involvement of hormones in the development of
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Evaluating the prediction power and accuracy of two smart response surface experimental designs after revisiting repaglinide floating tablets Future J. Pharm. Sci. Pub Date : 2024-03-05 Tarek Elsayed, Rania M. Hathout
There is a soar in the figure of companies aiming to achieve efficiency in undergoing experimental processes. Therefore, instead of deploying one-factor-at-a-time, design of experiments is becoming rampantly utilized in order to reduce the resources outflow. There are a copious of different smart designs which could be employed as design of experiments tools. Central composite and d-optimal designs
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Enhanced therapeutic approach for diabetic foot ulcers: comparative study and characterisation of mupirocin-loaded nanosponge gel with marketed formulation for accelerating wound healing and in vivo evaluation Future J. Pharm. Sci. Pub Date : 2024-03-04 Rushikesh S. Dhamak, Pramod S. Salve, Deepak R. Tiwari, Pradnya A. Raut, Darshan S. Waghmare
The current investigation aimed to develop, optimise, and assess a mupirocin-loaded nanosponge-based topical delivery system for diabetic foot ulcer and to achieve prolonged drug release while improving drug deposition within the skin. The nanosponges carrying mupirocin were formulated using the emulsion solvent diffusion method. A 32 factorial design was utilised to investigate effect of two factors
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Prognostic values and immune infiltration of KLF15, AQP7, AGPAT9 in glioma and glioblastoma Future J. Pharm. Sci. Pub Date : 2024-03-04 Ayobami Matthew Olajuyin, Onyinyechi Sharon Nwachukwu, Adefunke K. Olajuyin, Raji M. Hayatu, Adewale James, Akinrefon Adesupo, Ayodeji Mathias Adegoke, Adebola Idowu Akingbade
The overall survival of patients with lower-grade gliomas and glioblastoma varies greatly. No reliable or existing procedures can accurately forecast survival and prognostic biomarkers for early diagnosis in glioma and glioblastoma. However, investigations are progressing in immunotherapy, tumor purity, and tumor microenvironment which may be therapeutic targets for glioma and glioblastoma. This study
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Optimization of simvastatin transdermal patch for hyperlipidemia treatment in rat model Future J. Pharm. Sci. Pub Date : 2024-02-29 Neetu, Anubhav Anand, Dharamveer Panjwani
Biopharmaceutics Classification System says that simvastatin (SMV) is a Class II drug with low bioavailability (5%). This is because it dissolves slowly and is broken down a lot in the first pass. Simvastatin transdermal patches were produced as part of this study's aim to treat hyperlipidemia. The Box–Behnken design (three-factor, three-level) was selected for optimization of patches. The optimization
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Cordycepin alleviates osteoarthritis by inhibiting chondrocyte ferroptosis via Keap1/Nrf2 axis Future J. Pharm. Sci. Pub Date : 2024-02-28 Jianlei Li, Zuo Lv
Intervertebral disc degeneration (IVDD) is a prevalent condition known to contribute to lower back pain and various spinal disorders. The progression of IVDD is closely associated with cell ferroptosis. This study aimed to explore the therapeutic potential of a reactive oxygen species (ROS)-responsive hydrogel loaded with garlic extract for the inhibition of cell ferroptosis and the treatment of IVDD
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Multi-epitope-based vaccine designing against Junín virus glycoprotein: immunoinformatics approach Future J. Pharm. Sci. Pub Date : 2024-02-27 Mallari Praveen
The Junín virus (JUNV) is well known for causing argentine haemorrhagic fever (AHF), a severe endemic disease in farming premises. The glycoprotein of JUNV is an important therapeutic target in vaccine design. Despite using drugs and neutralizing weakened antibodies being used in the medication, neither the severity reduced nor eradicated the infection. However, this constraint can be resolved by immunoinformatic
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Efficacy evaluation of Berberis aristata and Silybum marianum fixed dose combination on glycaemic and insulin resistance parameters in adult population: a systematic review and meta-analysis of randomized controlled trials Future J. Pharm. Sci. Pub Date : 2024-02-27 Vishal Dubey, Jignesh Kansagra, Varun Sureja, Dharmeshkumar Kheni
Diabetes is one of the most prevalent metabolic diseases with high rate of morbidity and mortality. The increased level of blood glucose level and increased insulin resistance is the hallmark of diabetes. Currently, various non-pharmacological and pharmacological therapeutic options are used for lowering the glucose level and improving the insulin activity. The current systematic review and meta-analysis
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Antidiarrhoeal screening of Himalayan edible plant Begonia rubrovenia and its marker followed by its validation using computational analysis Future J. Pharm. Sci. Pub Date : 2024-02-27 Rupali S. Prasad, Jun M. Kalita, Nitish Rai, Nikhil Y. Yenorkar, Suhas R. Dhaswadikar, Pravesh Sharma, Mahaveer Dhobi, Damiki Laloo, Saurabh K. Sinha, Prakash R. Itankar, Satyendra K. Prasad
Diarrhoea has become one of the major areas of concern due to its high mortality rate contributing it to be the second largest cause of death in world. To explore the effectiveness of medicinal plant, the present investigation was undertaken to scientifically justify the traditional claim of the ethanolic root extract of the plant Begonia rubrovenia (EBV) against diarrhoea. EBV was standardized using
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Ethnozoological importance of Eisenia fetida and experimental validation of its anticancer activity in ascites Dalton’s lymphoma (DL) bearing mice Future J. Pharm. Sci. Pub Date : 2024-02-26 Manash Pratim Borah, Surya Bali Prasad
Eisenia fetida, commonly known as the red earthworm, holds significant ethnozoological importance due to its traditional use in various cultures as a medicinal agent. This study aims to explore the potential anticancer effects of Eisenia fetida paste (EFP) and evaluate its therapeutic efficacy in mice with ascites Dalton's lymphoma (DL). The EFP extract demonstrated a significant antitumour effect
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Biogenic metallic nanoparticles as game-changers in targeted cancer therapy: recent innovations and prospects Future J. Pharm. Sci. Pub Date : 2024-02-22 Moulika Todaria, Dipak Maity, Rajendra Awasthi
Cancer is a significant global health issue, resulting from uncontrolled cell division leading to abnormal cell or tissue growth. Traditional chemotherapeutic techniques have investigated a wide variety of pharmaceutically active molecules despite their poor bioavailability, quick renal clearance, inconsistent distribution, and unavoidable side effects. Green synthesis, unlike chemical methods, prioritizes
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Unveiling the anti-cancer potential of Euphorbia greenwayi: cytotoxicity, cell migration, and identification of its chemical constituents Future J. Pharm. Sci. Pub Date : 2024-02-21 Ahmed A. Zaghlol, Zeinab A. Kandil, Miriam F. Yousif, Riham Salah EL-Dine, Wafaa M. Elkady
Different herbal phytochemicals have potential in cancer treatment, Euphorbia genus has valuable secondary metabolites and is used in traditional medicine to treat various ailments. However, the specific constituents and biological activity of Euphorbia greenwayi remain largely unexplored. Euphorbia greenwayi aerial parts were extracted using methanol. Consequently, the methanol extract was then fractionated
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A validated, precise TLC-densitometry method for simultaneous quantification of mahanimbine and koenimbine in marketed herbal formulations Future J. Pharm. Sci. Pub Date : 2024-02-20 Nabarun Mukhopadhyay, Rezwan Ahmed, Kajal Mishra, Rujuta Sandbhor, Ram Jee Sharma, Venkata Rao Kaki
Murraya koenigii (L.) Spreng. (Rutaceae) is an important medicinal plant in natural products research for its diverse pharmacological activities. Carbazole alkaloids were the major classes of phytoconstituents obtained from different parts of this plant, such as leaves, stems, and roots. Mahanimbine and koenimbine are two important carbazole alkaloids obtained from the M. koenigii plant and are known
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Development and characterization of niosomes loaded mucoadhesive biodegradable ocular inserts for extended release of pilocarpine HCl Future J. Pharm. Sci. Pub Date : 2024-02-19 Tamara Ahmad Alotaibi, Affiong Iyire, Shereen Assaf, Eman Zmaily Dahmash
Pilocarpine HCl is a non-selective muscarinic receptor agonist that is prescribed for the treatment of glaucoma. The use of pilocarpine conventional eye drops is associated with several side effects, such as loss of visual acuity, and the need for several applications due to rapid drainage away via the nasolacrimal duct, especially for elderly people. Such adverse effects can lead to low patient compliance
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Qualitative assessment of the flowering buds of Mesua ferrea Linn with special emphasize on HPTLC and universal DNA bar-coding technique and evaluation of its antimicrobial potential Future J. Pharm. Sci. Pub Date : 2024-02-16 Jugal Sutradhar, Bapi Ray Sarkar
The study has been scientifically exploring the powder sample and extracts of flowering buds of Mesua ferrea Linn (FBMF) based on pharmacognostic and phytochemical parameters. The medicinal plant Mesua ferrea Linn was identified by Botanical verification and the universal DNA bar-coding technique. The FBMF powder’s quality was performed by the micromeritics properties like bulk density, tapped density
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Design, synthesis and in-vitro anti-depressant activity evaluation of some 2-styrylbenzimidazole derivatives Future J. Pharm. Sci. Pub Date : 2024-02-15 Manisha Sahariah, Rubina Chowdhury, Padmanath Pegu, Farak Ali, Rajat Subhra Dutta, Supriya Sahu
Existing antidepressants possess various adverse effects and so they are not considered as the first line of drug in mild depression. The lack of proper drugs to treat the mild depression on the other hand alleviates severe depressive cases. To overcome this problem, the nucleus of benzimidazole and cinnamic acid having very less toxicity were fused and a small library of 40 compounds was prepared
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Preparation and in vitro evaluation of BBG-250 loaded liposomal formulation for anticancer potential Future J. Pharm. Sci. Pub Date : 2024-02-12 Twinkle Gupta, Priyanshu Nema, Sakshi Soni, Vivek Yadav, Sanyog Jain, Vandana Soni, Sushil K. Kashaw
Liposome-mediated drug delivery systems have emerged as a promising avenue for enhancing cancer treatment strategies. This study aims to develop and assess liposomal carriers loaded with Brilliant Blue G-250 (BBG-250), a potent P2X7 receptor antagonist that shows potential as an anti-tumor agent. Specifically, two types of liposomal formulations were designed: conventional liposomes composed of hydrogenated
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Development of superior chitosan–EDTA microparticles as an adsorbent base for solidifying the self-emulsifying drug delivery systems Future J. Pharm. Sci. Pub Date : 2024-02-12 Mohit Kumar, Pooja A. Chawla, Abdul Faruk, Viney Chawla, Shubham Thakur, Subheet Kumar Jain
The present study focused on developing a superior adsorbent carrier (microparticles) to solidify the self-emulsifying drug delivery system. The two approaches, solvent evaporation and spray drying, were explored to synthesize the microparticles using chitosan (CH) and EDTA disodium. The 32 full factorial design was applied to optimize the microparticle process produced by both methods. The various
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The possible anti-inflammatory effect of extra virgin olive oil with colchicine in treatment of resistant cases of familial Mediterranean fever in a cohort of pediatric Egyptian patients Future J. Pharm. Sci. Pub Date : 2024-02-12 Walla’a A. Osman, Heba Taher, Hanan Darweesh, Mai Abdel Samie, Olfat G. Shaker, Dina A. Labib, Hayam Ateyya
People of Mediterranean descent are primarily affected by the autoinflammatory genetic condition known as familial Mediterranean fever (FMF). The disease is resistant to colchicine therapy in 10–20% of patients. Numerous recent animal studies showed promising results of extra virgin olive oil (EVOO) to control inflammation. The objective of this study was to assess the effectiveness of combining EVOO
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Pharmaceutical significance of Schiff bases: an overview Future J. Pharm. Sci. Pub Date : 2024-02-12 Irfan Mushtaq, Maqbool Ahmad, Muhammad Saleem, Adnan Ahmed
Schiff bases are a diverse group of organic compounds with great pharmaceutical importance due to the presence of carbon–nitrogen double bonds (–C=N–). These compounds are synthesized by the condensation reaction between a primary amine and an aldehyde or ketone in a suitable solvent such as methanol. These compounds have shown antibacterial, antifungal, antiviral, anti-inflammatory, and antioxidant
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Brentuximab vedotin resistance in classic Hodgkin's lymphoma and its therapeutic strategies: a review Future J. Pharm. Sci. Pub Date : 2024-02-09 Dayeeta Bera, Dattatreya Roy
Bone marrow cancer has been at the forefront of cancer research. The propensity of cancers to extravasate to the bone makes it a very relevant topic in the topology of this heterogeneous disease. Our narrative review article addresses Brentuximab vedotin (BV) resistance in classic Hodgkin’s lymphoma patients and discusses the current trends in the therapeutic process. The data have been collected from
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Nanotechnology-based strategies overcoming the challenges of retinoblastoma: a comprehensive overview and future perspectives Future J. Pharm. Sci. Pub Date : 2024-02-09 Shymaa Hatem, Donia Mohammed, Nermeen Ezzat
Retinoblastoma (RB) is a rare type of pediatric ocular cancer with difficulty in treatment and detection owing to alterations in tumor suppressor genes and the lack of focused, efficient, and cost-effective treatments. The current review presents different approaches adopted for the treatment of RB. Recently, nanodrug delivery-based systems have shown significant reported advancements in RB treatment
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Quisqualis indica Linn.: HRLCMS/MS profiling and anti-asthma activity of leaf extracts Future J. Pharm. Sci. Pub Date : 2024-02-07 Charulata T. Nemade, Anilkumar N. Aher
Asthma is a chronic inflammatory disorder of the airways, involving various cells and cellular elements precisely eosinophils, mast cells, neutrophils, T lymphocytes, epithelial cells, and macrophages. Worldwide, about 300 million people are affected by asthma, and is expected that 100 million people may get affected, in 2025. Quisqualis indica is commonly planted as an ornamental plant in India; and
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Seaweeds as a potential resource in diabetes management: a review Future J. Pharm. Sci. Pub Date : 2024-02-07 J. S. Vidyashree, Priya P. Shetti, Shridhar C. Ghagane
Seaweeds are the marine macroalgae predominantly found in the coastal regions. These species have unique chemical profiles which makes them stand different from terrestrial plants. They are found to be rich in secondary metabolites which have potential in treating various unhealthy conditions. Diabetes is a chronic condition where an individual suffers from high or low sugar levels in the blood. This
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Comprehensive preclinical studies on the bioactivity of Orbignya phalerata Mart. (Babassu) and its derived products: a systematic review Future J. Pharm. Sci. Pub Date : 2024-01-31 Nicole Debia, Isione Oliveira Castro, Ana Beatriz Santana Sousa, Victor Alves de Oliveira, Helber Alves Negreiros, Paulo Michel Pinheiro Ferreira, João Marcelo de Castro e Sousa
Babassu (Orbignya phalerata Mart.) is a palm tree well distributed in Latin America, whose fruit has a mesocarp and kernel used for human feeding, and empirically related to the treatment of gastritis, vaginitis, and wound healing. The activities attributed to babassu can guide new research on health applications and, for this reason, this study aimed to report in vitro and in vivo biological activities
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Screening and characterization of bioactive compounds from two epiphytic microlichen and evaluation of their in vitro antioxidant activity Future J. Pharm. Sci. Pub Date : 2024-01-31 Shubham Pradhan, Satyabrata Dash, Bijayananda Sahoo, Sabyasachy Parida, Biswajit Rath
Lichens in symbiosis produce a wide range of primary and secondary fine compounds in extreme environmental conditions that have a broad range of biological properties as well as antioxidant potential and can be used in future pharmaceuticals as a natural source of antioxidant molecules. The two microlichen species collected are identified based on morphological and molecular techniques; further studies
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Assessment of potential drug–drug interaction knowledge, attitude, and practice among Egyptian hospital and community pharmacists: a cross-sectional multicenter study Future J. Pharm. Sci. Pub Date : 2024-01-29 Engy A. Wahsh, Ahmed E. Abou Warda, Mahmoud S. Abdallah, Aya Elsayed, Yasser Soliman Abdel Daiem, Eman Mohamed Sadek
Pharmacists have an important role in preventing prescribing errors and providing appropriate information. They can detect potential drug–drug interactions (DDIs), which are associated with a more extended hospital stay and higher medical costs that lead to substantial financial burdens on healthcare systems. This study aimed to evaluate and assess the knowledge of community and hospital pharmacists
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A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study Future J. Pharm. Sci. Pub Date : 2024-01-19 Haitham A. El Fiky, Maha F. Abd El Ghany, Amr M. Badawey, N. V. Fares, Dina A. Ahmed
Carivalan® dosage form containing carvedilol and ivabradine is widely indicated for patients with stable angina. Three precise, eco-friendly and reproducible spectrophotometric techniques were created for resolving the researched drugs in their mixtures using zero and/or ratio spectra. Technique I is a factorized dual wavelength coupled with spectrum subtraction (FDW-SS), technique II is a ratio difference
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In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma Future J. Pharm. Sci. Pub Date : 2024-01-12 Marvin Antonio Soriano-Ursúa, Angélica Vega-García, Vinnitsa Buzoianu-Anguiano, Ana Lilia Ocampo-Nestor, Joaquín Manjarrez-Marmolejo, Iris Angélica Feria-Romero
Diffuse astrocytoma (a type of glioma) and its prevalence are matters of concern worldwide. Patients with this type of tumour have a poor prognosis because after surgical treatment, radiotherapy and/or chemotherapy, these tumours eventually regrow or progress. To date, there is no effective treatment that can cure affected patients. Quercetin and 3-bromopyruvate are chemical compounds that have been
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Antioxidant and acetylcholinesterase inhibitory activities, in silico analyses, and anti-Alzheimer’s disease potential of leaf extracts of three Nigerian endemic medicinal plants (Spondias mombin, Carica papaya and Kalanchoe crenata) Future J. Pharm. Sci. Pub Date : 2024-01-08 Aanuoluwapo Ruth Adetuyi, Michael E. Ayenero, Mary T. Olaleye, Afolabi A. Akindahunsi, Afolabi C. Akinmoladun
The evaluation of the correlations between antioxidant and anti-acetylcholinesterase activities of methanol leaf extracts of three Nigerian endemic plants, Spondias mombin, Carica papaya and Kalanchoe crenata, was carried out. Their constituent phytochemicals were identified by HPLC–DAD fingerprinting. The antioxidant activity as typified by 2,2-diphenyl-1-picrylhydrazyl (DPPH·), 2,2′-azino-bis-(3
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Unlocking the power of precision medicine: exploring the role of biomarkers in cancer management Future J. Pharm. Sci. Pub Date : 2024-01-05 Dipak D. Gadade, Hariom Jha, Chetan Kumar, Farzan Khan
Personalized or Precision medicine (PM) is a promising approach for the cancer treatment that tailors treatment to a patient's characteristics. Biomarkers are crucial for identifying the patients who are expected to derive greatest advantage from targeted therapy. Here, various biomarkers, including genetic, epigenetic, protein, and metabolites, and their clinical significance, are discussed. The review
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Nanocrystals: an emerging paradigm for cancer therapeutics Future J. Pharm. Sci. Pub Date : 2024-01-05 Ayush Patel, Krishi Patel, Viral Patel, Mithun Singh Rajput, Ravish Patel, Amarjitsing Rajput
Medical fraternity are continuously pitching toward the development of novel mechanisms to combat the menace of cancer and to enhance the efficacy of prevailing molecules. During the drug development phase, majority of new molecular entity pose a threat due to hydrophobic nature, that compromises its bioavailability upon administration. These suboptimal accumulation and low drug loading hampers the
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Integrating in silico molecular docking, ADMET analysis of C.verticillata with diabetic markers and in vitro anti-inflammatory activity Future J. Pharm. Sci. Pub Date : 2024-01-05 Maheswari A., Salamun DE
Over the past decade, various research studies have proved the interconnection between the inflammatory pathways and diabetes complication in clinical condition. The present study evaluated the anti-inflammatory and antioxidant activity. Further, the sample was tested for its pharmacokinetics properties and the best compounds were docked with the diabetic markers (DPP IV (PDB-ID: IJ2E) and SGLT2 (PDB-ID:
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Multifaceted applications of micro/nanorobots in pharmaceutical drug delivery systems: a comprehensive review Future J. Pharm. Sci. Pub Date : 2024-01-03 Tanisha Das, Shirin Sultana
Drug delivery systems (DDSs) encompass a wide range of methods, including oral, injectable, and topical routes of administration, all tailored to meet specific patient needs. Micro and nanorobots, equipped with pioneering propulsion mechanisms that convert external energy sources into precise movements, have revolutionized drug delivery. This cutting-edge technology ensures highly efficient drug delivery