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Nanoplastics aggravated TDCIPP-induced transgenerational developmental neurotoxicity in zebrafish depending on the involvement of the dopamine signaling pathway Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-09 Xin Ren, Zhibo Liu, Ruiqi Zhang, Yuting Shao, Xiaoyue Duan, Bo Sun, Xuesong Zhao
Plastics pose a hazard to the environment. Although plastics have toxicity, microplastics (MPs) and nanoplastics (NPs) are capable of interacting with the rest pollutants in the environment, so they serve as the carriers and interact with organic pollutants to modulate their toxicity, thus resulting in unpredictable ecological risks. PS-NPs and TDCIPP were used expose from 2 h post-fertilization (hpf)
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Blood and tissue levels of persistent organic pollutants and genetic susceptibility in patients with breast cancer Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-06 İlgen Onat, Rasih Kocagöz, Merve Demirbügen Öz, Levent Yeniay, Yiğit Özer Tiftikçioğlu, Osman Zekioğlu, Gürdeniz Serin, Murat Özdemir, Ersin Gür, Halit Sinan Süzen, Hilmi Orhan
We investigated possible associations between the internal concentrations of POPs and correlations between blood and tumor tissue concentrations in patients who underwent surgery for breast cancer and breast reduction as controls. Genetic variations in CYP1A1, GSTP1, GSTM1, and GSTT1 and hOGG1 were evaluated to determine whether they represent risk factors for breast cancer. Certain POPs have been
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Impact of endocrine-active compounds on adrenal androgen production in pigs during neonatal period Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-06 Katarzyna Knapczyk-Stwora, Aleksandra Kozlowska, Damian Jastrzabek, Malgorzata Grzesiak, Maria Slomczynska, Marek Koziorowski
This study investigated the impact of neonatal exposure to endocrine-active compounds (EACs): flutamide (antiandrogen), 4--octylphenol (an estrogenic compound), and methoxychlor (an organochlorine insecticide exhibiting estrogenic, antiestrogenic and antiandrogenic activities) on androgen production within porcine adrenal glands. The expression of genes related to androgen synthesis and the level of
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Growth and physiological responses of submerged macrophytes to linear alkylbenzene sulfonate (LAS) Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-05 Cui-Min Han, Wen-Hua You
The potential toxic effects of linear alkylbenzene sulfonate (LAS), widely used in commercial detergents and cleaners, on submerged macrophytes remain unclear. We conducted a two-week exposure experiment to investigate LAS toxicity on five submerged macrophytes (four native and one exotic), focusing on their growth and physiological responses. The results showed that lower concentrations of LAS (<
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Surviving in a multistressor world: Gene expression changes in earthworms exposed to heat, desiccation, and chemicals Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-01 Natasha Tilikj, Mercedes de la Fuente, Ana Belén Muñiz González, José-Luis Martínez-Guitarte, Marta Novo
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Investigating the toxic mechanism of iron oxide nanoparticles-induced oxidative stress in tadpole (Duttaphrynus melanostictus): A combined biochemical and molecular study Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-28 Meesala Krishna Murthy, Pratima Khandayataray, Chandra Sekhar Mohanty, Rojalin Pattanayak
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Biological responses in Danio rerio by the disinfectant SDBS in SARS-CoV-2 pandemic Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-28 Beatriz Sousa, Inês Domingues, Bruno Nunes
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Concentration of trace elements in blood of Polish patients with prostate cancer Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-28 Joanna Maria Drozdz-Afelt, Beata Koim-Puchowska, Piotr Kaminski
The goal of the study was to analyse the concentrations of chemical elements (Fe, Ni, As, Cd, Pb, Hg, Cr, Zn) which are important for the determination of environmental toxins (e.g. resulting from smoking, exposure to harmful agents at work) in Polish patients with prostate cancer. The study covered 66 patients with diagnosed prostate cancer and 64 healthy volunteers over 50 years old. The analysis
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Chronic Aroclor 1260 exposure alters the mouse liver proteome, selenoproteins, and metals in steatotic liver disease Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-27 Kellianne M. Piell, Belinda J. Petri, Jason Xu, Lu Cai, Shesh N. Rai, Ming Li, Daniel W. Wilkey, Michael L. Merchant, Matthew C. Cave, Carolyn M. Klinge
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Glyphosate and aminomethylphosphonic acid metabolite (AMPA) modulate the phenotype of murine melanoma B16-F1 cells Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-26 Yvanna Carla de Souza Salgado Kiefer, Marianna Boia Ferreira, Jessica Zablocki da Luz, Francisco Filipak Neto, Ciro Alberto de Oliveira Ribeiro
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Exposure to the antineoplastic ifosfamide alters molecular pathways related to cardiovascular function, increases heart rate, and induces hyperactivity in zebrafish (Danio rerio) Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-23 Cole D. English, Kira J. Kazi, Isaac Konig, Emma Ivantsova, Christopher L. Souders II, Christopher J. Martyniuk
Ifosfamide is an alkylating antineoplastic drug used in chemotherapy, but it is also detected in wastewater. Here, the objectives were to (1) determine teratogenic, cardiotoxic, and mitochondrial toxicity potential of ifosfamide exposure; (2) elucidate mechanisms of toxicity; (3) characterize exposure effects on larval behavior. Survival rate, hatch rate, and morphological deformity incidence were
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Polystyrene microplastics with absorbed nonylphenol induce intestinal dysfunction in human Caco-2 cells Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-23 Fangfang Ding, Huimei Wang, Yingzhi Li, Xueping Leng, Jiaming Gao, Danfei Huang
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Transcriptional and phenotypical alterations associated with a gradual benzo[a]pyrene-induced transition of human bronchial epithelial cells into mesenchymal-like cells Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-22 Martina Hýžďalová, Jiřina Procházková, Nicol Straková, Kateřina Pěnčíková, Simona Strapáčová, Jana Slováčková, Simona Kajabová, Helena Líbalová, Jan Topinka, Markéta Kabátková, Jan Vondráček, Steen Mollerup, Miroslav Machala
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Biotoxicity responses of zebrafish in environmentally relevant concentration of di (2-ethylhexyl) phthalate Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-21 Xianxu Li, Shichang Hu, Nan Jiang, Xiangfeng Yao, Can Wang, Qian Wang, Zhongkang Yang, Jun Wang
As an emerging environmental contaminant, di (2-ethylhexyl) phthalate (DEHP) is widely present in the aquatic environment, however, the effects and underlying mechanisms of DEHP on the aquatic organisms are poorly understood. This study systematically investigated the ecotoxicity induced by chronic exposure to environmental relevant concentrations of DEHP (0.03 mg/L, 0.1 mg/L, and 0.3 mg/L) on zebrafish
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Anabolic steroids induced changes at the level of protein expression: Effects of prolonged administration of testosterone and nandrolone to pigs Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-21 Jan Gebauer, Nikola Hodkovicova, Kristina Tosnerova, Kristyna Skoupa, Andrej Batik, Iva Bartejsova, Michaela Charvatova, Lenka Leva, Rea Jarosova, Zbysek Sladek, Martin Faldyna, Kamil Stastny
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Beauvericin and enniatin B mycotoxins alter aquatic ecosystems: Effects on green algae Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-19 Ana Juan-García, Cristina Juan, Sami Taipale, Eeva-Riikka Vehniäinen
Myxotoxins can contaminate algal-based products and arrive to the food chain to consumers producing chronic toxicity effects. Here, we studied phytotoxicity of mycotoxins, beauvericin (BEA) and ennaitin B (ENN B) in four phytoplankton strains: , , and , which are all green algae. It was tested the capacity of clearing the media of BEA and ENN B at different concentrations by comparing nominal and measured
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Plants buffer some of the effects of a pair of cadmium-exposed zebrafish on the un-exposed majority Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-18 Delia S. Shelton, Piyumika S. Suriyampola, Zoe M. Dinges, Stephen P. Glaholt, Joseph R. Shaw, Emília P. Martins
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The ABCG2 protein in vitro transports the xenobiotic thiabendazole and increases the appearance of its residues in milk Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-16 Laura Álvarez–Fernández, Esther Blanco–Paniagua, Alicia Millán–García, Miriam Velasco-Díez, Ana I. Álvarez, Gracia Merino
Thiabendazole (TBZ) is a broad–spectrum anthelmintic and fungicide used in humans, animals, and agricultural commodities. TBZ residues are present in crops and animal products, including milk, posing a risk to food safety and public health. ABCG2 is a membrane transporter which affects bioavailability and milk secretion of xenobiotics. Therefore, the aim of this work was to characterize the role of
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Is photoelectrocatalysis an efficient process to degrade endocrine disruptors chemicals? Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-16 M. Cifre-Herrando, G. Roselló-Márquez, J. García-Antón
Endocrine disruptors chemicals (EDCs) pose significant health risks, including cancer, behavioral disorders, and infertility. In this study, we employed the photoelectrocatalysis (PEC) technique with optimized tungsten oxide (WO) nanostructures as a photoanode to degrade three diverse EDCs: methiocarb, dimethyl phthalate, and 4-tert-butylphenol. PEC degradation tests were carried out for individual
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In vivo assessment of the toxic impact of exposure to magnetic iron oxide nanoparticles (IONPs) using Drosophila melanogaster Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-16 Merve Güneş, Kemal Aktaş, Burçin Yalçın, Ayşen Yağmur Burgazlı, Meltem Asilturk, Ayca Erdem Ünşar, Bülent Kaya
Iron oxide nanoparticles (IONPs) have useful properties, such as strong magnetism and compatibility with living organisms which is preferable for medical applications such as drug delivery and imaging. However, increasing use of these materials, especially in medicine, has raised concerns regarding potential risks to human health. In this study, IONPs were coated with silicon dioxide (SiO), citric
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Role of prolactin in the protective effect of amisulpride against 1,2-Diacetylbenzene’s neurotoxicity Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-15 Ngoc Minh-Hong Hoang, Hai Duc Nguyen, Wonhee Jo, Min-Sun Kim
Exposure to organic solvents is associated with various health problems, including neurodegenerative diseases. Among these solvents, 1,2-diethylbenzene is notable for its ability to produce a toxic metabolite, 1,2-Diacetylbenzene (DAB), which can cause memory impairment. Prolactin (PRL) is theorized to protect the central nervous system. Certain antipsychotic drugs, known for increasing PRL secretion
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AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-15 Betul Cicek, Ahmet Hacimuftuoglu, Yesim Yeni, Mehmet Kuzucu, Sidika Genc, Ahmet Cetin, Emre Yavuz, Betul Danısman, Akin Levent, Kemal Volkan Ozdokur, Mecit Kantarcı, Anca Oana Docea, Vasileios Siokas, Konstantinos Tsarouhas, Michael D. Coleman, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously
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Fine particulate matter PM2.5 and its constituent, hexavalent chromium induce acute cytotoxicity in human airway epithelial cells via inflammasome-mediated pyroptosis Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-15 Aekkacha Moonwiriyakit, Sasiwimol Dinsuwannakol, Jenjira Sontikun, Kanokphorn Timpratueang, Chatchai Muanprasat, Phisit Khemawoot
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A meta-analysis of potential biomarkers associated with microplastic ingestion in marine fish Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-13 Montserrat Compa, Xavier Capó, Carme Alomar, Salud Deudero, Antoni Sureda
Over the past decade, global reports have shown a rise in the harmful effects of microplastics (MPs) on marine fish. This study analysed marine species' biochemical biomarker responses to microplastic exposure, finding that MPs can induce oxidative stress in marine fish through meta-regression results. Overall, exposure to MPs resulted in the activation of antioxidant defence mechanisms, such as superoxide
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Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-13 Pernille Høgh Danielsen, Sarah Søs Poulsen, Kristina Bram Knudsen, Per Axel Clausen, Keld Alstrup Jensen, Håkan Wallin, Ulla Vogel
Carbon nanotubes (CNTs) vary in physicochemical properties which makes risk assessment challenging. Mice were pulmonary exposed to 26 well-characterized CNTs using the same experimental design and followed for one day, 28 days or 3 months. This resulted in a unique dataset, which was used to identify physicochemical predictors of pulmonary inflammation and systemic acute phase response. MWCNT diameter
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Intravenous hypertonic fluids as a source of human microplastic exposure Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-03-05 Uğur Çağlayan, Sedat Gündoğdu, Tiffany M. Ramos, Kristian Syberg
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Cardiovascular disrupting effects of bisphenols, phthalates, and parabens related to endothelial dysfunction: Review of toxicological and pharmacological mechanisms Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-28 Cristina Lemini, Patricia Silveyra, Mariana Segovia-Mendoza
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Effect of beta-cypermethrin on the reproductive capacity of female mice in advanced age Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-28 Qian-Feng Qiao, Li-Qing Wang, De-E. Yu, Na Li, Qiong-Jun Xu, Yong-Jiang Zhou
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Decreased immune response in undernourished rats after air pollution exposure Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-24 Melisa Lidia Kurtz, Nadia Soledad Orona, Christian Lezón, Verónica Cecilia Defosse, Francisco Astort, Guillermo Alberto Maglione, Patricia Mónica Boyer, Deborah Ruth Tasat
Children are highly vulnerable subpopulation to malnutrition and air pollution. We investigate, in a rat nutritional growth retardation (NGR) model, the impact of Residual Oil Fly Ash (ROFA) on the lung immune response using and methods. : Alveolar macrophages (AM) were isolated from Control (C) and NGR animals, cultured and treated with ROFA (1–100 µg/ml) for 24 h. : C and NGR rats were intranasally
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Chronic arsenic exposure suppresses proteasomal and autophagic protein degradation Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-23 Isabell I. Augenstein, Alexandra N. Nail, Ana P. Ferragut Cardoso, J. Christopher States, Mayukh Banerjee
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Protection against β-N-methylamino-l-alanineꟷinduced vesicular monoamine transporter 2 inhibition by hydroxyl-containing proteinogenic amino acids Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-23 Rianita van Onselen, Chanté Kennedy, Tim G. Downing
β--methylamino--alanine (BMAA) has been shown to inhibit vesicular monoamine transporter 2 (VMAT2), thereby preventing the uptake of monoaminergic neurotransmitters into platelet dense granules and synaptic vesicles. The inhibition is hypothesized to be through direct association of BMAA with hydroxyl groupꟷcontaining amino acid residues in VMAT2. This study evaluated whether BMAA-induced inhibition
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Short-term effects of sodium arsenite (AsIII) and sodium arsenate (AsV) on carbohydrate metabolism in the perfused rat liver Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-23 Nairana Mithieli de Queiroz Eskuarek Melo, Jurandir Fernando Comar, Anacharis Babeto de Sá-Nakanishi, Rosane Marina Peralta, Lívia Bracht, Adelar Bracht
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Lead induced genotoxicity and hepatotoxicity in zebrafish (Danio rerio) at environmentally relevant concentration: Nrf2-Keap1 regulated stress response and expression of biomarker genes Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-22 Koushik Kumar Dey, Sreejata Kamila, Tanmoy Das, Ansuman Chattopadhyay
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Metal bioaccumulation and histological alterations in Oreochromis andersonii at Itezhi-tezhi Dam downstream of a mining area in the Central Province of Zambia Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-19 Chris Sihoka, Ina Wagenaar, Cobus van Dyk
The Itezhi-tezhi Dam on the Kafue River in Zambia is a major capture fishery. However, the upstream reaches of the Kafue River receive effluents from copper mines. It was unclear whether fish health in the dam is adversely affected due to the mining effluents. We investigated the health status of fish in Itezhi-tezh Dam using a histology-based fish health assessment protocol with as a bioindicator
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E-cigarettes exacerbate allergic inflammation via cytokine induction and MUC5AC/5B expression in a murine asthma model Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-19 Young-Ha Lee, Hyung Gyun Na, Yoon Seok Choi, Chang Hoon Bae, Si-Youn Song, Yong-Dae Kim
The effects of electronic cigarettes (e-cigarettes) vapor on inflammation and mucin secretion on asthmatics remain insufficiently explored. This study investigated the effects of e-cigarette vapor on allergic inflammation, cytokine production, and MUC5AC/5B expression in murine asthma model. Airway hyperresponsiveness was significantly higher in the e-cigarette-exposed ovalbumin (OVA) sensitization
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Genotoxicity responses of single and mixed exposure to heavy metals (cadmium, silver, and copper) as environmental pollutants in Drosophila melanogaster Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-16 Eşref Demir, Fatma Turna Demir
Heavy metals are now persistently present in living things' environments, in addition to their potential toxicity. Therefore, the aim of this study was to utilize . to determine the biological effects induced by different heavy metals including cadmium chloride (CdCl), copper (II) sulfate pentahydrate (CuSO 4.5 HO), and silver nitrate (AgNO). experiments were conducted utilizing three low and environmentally
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Impact of DEHP exposure on female reproductive health: Insights into uterine effects Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-16 Alejandra Martínez-Ibarra, Marco Cerbón, Luis Daniel Martínez-Razo, Miguel Morales-Pacheco, Iván Torre-Villalvazo, Simón Kawa, Mauricio Rodríguez-Dorantes
Several endocrine disrupting compounds released from plastics, including polyfluoroalkyl substances, bisphenols, flame retardants, phthalates and others, are of great concern to human health due to their high toxicity. This review discusses the effects of di-(2-ethylhexyl) phthalate (DEHP), the most common member of the phthalate family, on female reproduction. and studies link DEHP exposure to impaired
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PM2.5 induces cardiac defects via AHR-SIRT1-PGC-1α mediated mitochondrial damage Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-15 Jin Chen, Mingxuan Zhang, Stanley Aniagu, Yan Jiang, Tao Chen
Recent evidence indicates that PM poses a risk for congenital heart diseases but the mechanisms remain unclear. We hypothesized that AHR activated by PM might cause mitochondrial damage via PGC-1α dysregulation, leading to heart defects. We initially discovered that the PGC-1α activator ZLN005 counteracted cardiac defects in zebrafish larvae exposed to EOM (extractable organic matter) from PM. Moreover
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Butyl Benzyl Phthalate (BBP) disrupts neuromast development in embryonic zebrafish Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-15 Evelyn Paquette, John Paul Giacalone, Michael Fumo, Nicole M. Roy
Butyl benzyl phthalate (BBP) is found in common household and industrial products world-wide. Phthalates are not covalently bound to plastics and continuously leach into the soil, sediment and aquatic environments. The lateral line system of fish is a mechanosensory system composed of neuromasts essential for survival behaviors including rheotaxis, schooling and predator avoidance. Here, we investigated
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Histological Evidence of Hypothyroidism in Mice Chronically Exposed to Conventional Farming (Revised) Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-14 Nádia Coelho, Ricardo Camarinho, Patrícia Garcia, Armindo S Rodrigues
Worldwide, disorders of the thyroid gland are a growing concern; such can be caused by exposure to contaminants, including agrochemicals used in conventional agriculture, which act as endocrine disruptors. The purpose of this study is to evaluate whether or not exposure to an environment with conventional agriculture leads to thyroid disruption. were used as bioindicator species, captured in two sites:
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Depletion kinetics of semicarbazide in giant river prawn (Macrobrachium rosenbergii) following nitrofurazone oral administration and its occurrence in an aquaculture farm Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-13 Putsucha Phansawat, Niti Chuchird, Arunothai Keetanon, Natnicha Chongprachavat, Phongchate Pichitkul, Natthapong Paankhao, Suwinai Paankhao, Lalitphan Kitsanayanyong, Puttharat Baoprasertkul, Tirawat Rairat
Semicarbazide (SEM), a marker residue used to monitor the use of prohibited drug nitrofurazone (NFZ), is commonly found in wild crustaceans, implying the natural origin. However, the difference between endogenous and exogenous SEM has rarely been investigated. So, tissue-bound SEM was determined in samples collected from giant river prawns cultured in an aquaculture farm and in samples from an experiment
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Chronic exposure to 2,2′-azobis-2-amidinopropane that induces intestinal damage and oxidative stress in larvae of Drosophila melanogaster Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-13 Rener Mateus Francisco Duarte, Serena Mares Malta, Fernanda Naves Araújo do Prado Mascarenhas, Vinicius Prado Bittar, Ana Luiza Borges, Renata Roland Teixeira, Renata Graciele Zanon, Carlos Ueira Vieira, Foued Salmen Espindola
Embryonic development is exceptionally susceptible to pathogenic, chemistry and mechanical stressors as they can disrupt homeostasis, causing damage and impacted viability. Oxidative stress has the capacity to induce alterations and reshape the environment. However, the specific impacts of these oxidative stress-induced damages in the gastrointestinal tract of larvae have been minimally explored. This
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A model naphthenic acid decouples oxidative phosphorylation through selective inhibition of mitochondrial complex activity Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-09 Zahra Kalvani, Collins Kamunde, Don Stevens, Michael R. van den Heuvel
The naphthenic acid fraction compound (NAFC), 3,5-dimethyladamantane-1-acetic acid, was tested for its ability to uncouple mitochondrial oxidative phosphorylation. Mitochondria isolated from rainbow trout () liver were exposed to 3,5-dimethyladamantane-1-acetic acid in state 3 and 4 respiration, and mitochondrial membrane potential were quantified. Electron transport chain (ETC) protein complexes were
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Oxidative stress-activated Nrf2 remitted polystyrene nanoplastic-induced mitochondrial damage and inflammatory response in HepG2 cells Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-08 Menghao Guo, Yunjing Li, Shuyan Niu, Rui Zhang, Xin Shen, Yu Ma, Liqing Wu, Tianshu Wu, Ting Zhang, Meng Tang, Yuying Xue
Generated from plastics, microplastics (MPs) and nanoplastics (NPs) are difficult to completely degrade in the natural environment, which can accumulate in almost all lives. Liver is one of the main target organs. In this study, HepG2 and L02 cells were exposed to 0-50μg/mL polystyrene (PS)-NPs to investigate the mechanism of mitochondrial damage and inflammation. The results showed mitochondria damage
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Evaluating the persistence of malachite green residues in tilapia and pacu fish Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-06 Lucas Victor Pereira de Freitas, Juliana Grell Fernandes Silveira, Marina Alves Damaceno, Sarah Chagas Campanharo, Agnaldo Fernando Baldo da Silva, da Silva Jonas Joaquim Mangabeira, Ana Carolina Vellosa Portela, Raphael Barbetta de Jesus, James Jacob Sasanya, Fabiana Pilarski, Susanne Rath, Jonas Augusto Rizzato Paschoal
Although banned in food-producing animals, residues of malachite green (MG) and its primary metabolite, leucomalachite green (LMG), have been found in fish due to illegal use in aquaculture and the release of industrial wastewater, which represent a serious risk to food and environmental securities. This study aimed to investigate the residue depletion profile of MG and LMG in edible tissues of Nile
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Are the new phthalates safe? Evaluation of Diisononilphtalate (DINP) effects in porcine ovarian cell cultures Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-06 G. Basini, S. Bussolati, S. Grolli, P. Berni, F. Grasselli
Phthalates are plasticizing chemicals, widely used in packaging materials and consumer products for several decades. These molecules have raised concerns because of their toxicity and their use have been restricted in several countries. Therefore, novel phthalates have been introduced. Among these, diisononilphtalate (DINP) is widely employed. However, its safety has not been properly addressed. Therefore
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Adverse effects of 2,4-D dimethylammonium based-herbicide on Acetylcholinesterase expression in Nile tilapia (Oreochromis niloticus) Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-05 Chutima Thanomsit, Prang Khanchanasal, Witchuda Prasatkaew, Jakkaphun Nanuam, Panomsak Meemon, Amnuay Wattanakornsiri, Phochit Nanthanawat
In this study, the evaluation of a 2,4-D dimethylammonium based-herbicide impacted on Nile tilapia was done. The effects focus on Acetylcholinesterase (AChE) expression in the brain, gill, muscle, and plasma using antibody techniques. Our findings revealed a decrease in AChE expression with prolonged exposure. For these, AChE was purified using hydroxyapatite column chromatography. Moreover, the isolated
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Long-term impacts of endocrine-disrupting chemicals exposure on kidney function: A community-based cohort study Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-02 Chun-Yu Chen, Chin-Chan Lee, Heng-Jung Hsu, I-Wen Wu, Yung-Chang Chen, Heng-Chih Pan, Yih-Ting Chen, Cheng-Kai Hsu, Chiao-Yin Sun
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Neurotoxicity of glyphosate: Focus on molecular mechanisms probably associated with alterations in cognition and behavior Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-02 Jesús Chávez-Reyes, Cristian D. Gutiérrez-Reyes, Eduardo Hernández-Cuellar, Bruno A. Marichal-Cancino
In recent decades, glyphosate (Gly) and glyphosate-based herbicides (GBH) have been extensively used in agriculture all over the world. Initially, they were considered safe, but rising evidence suggests that these molecules reach the central nervous system producing metabolic, functional, and permanent alterations that impact cognition and behavior. This theoretical and non-systematic review involved
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Modeling mixtures interactions in environmental toxicology Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-02 James Y. Liu, Christie M. Sayes
In the environment, organisms are exposed to mixtures of different toxicants, which may interact in ways that are difficult to predict when only considering each component individually. Adapting and expanding tools from pharmacology, the toxicology field uses analytical, graphical, and computational methods to identify and quantify interactions in multi-component mixtures. The two general frameworks
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Cytotoxicity of vanadium dioxide nanoparticles to human embryonic kidney cell line: Compared with vanadium(IV/V) ions Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-29 Jia-Bei Li, Dan Li, Yuan-Yuan Liu, Aoneng Cao, Haifang Wang
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Modulation in growth, oxidative stress, photosynthesis, and morphology reveals higher toxicity of alpha-cypermethrin than chlorpyrifos towards a non-target green alga at high doses Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-24 Prithu Baruah, Akanksha Srivastava, Yogesh Mishra, Neha Chaurasia
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Polystyrene microplastics effects on zebrafish embryological development: Comparison of two different sizes Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-19 Alessandra La Pietra, Gianluca Fasciolo, Daniela Lucariello, Chiara Maria Motta, Paola Venditti, Ida Ferrandino
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Physiological responses of oxidative damage, genotoxicity and hematological parameters of the toxic effect of neonicotinoid-thiamethoxam in Oreochromis niloticus Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-23 Özge Temiz, Dicle Kargın
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Hepatocellular degeneration in mice co-exposed to in-utero aluminium and cadmium: Implication of a disordered antioxidant and energy homeostatic response in the liver Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-21 Omamuyovwi Irerhievwie, Patrick Chukwuyenum Ichipi-Ifukor, Samuel Ogheneovo Asagba
The current study comprised four groups of pregnant animals viz; Control (CTR) received 10 ml/kg of normal saline, Al:10 mg/kg of AlCl3, Cd: 1.5 mg/Kg of CdCl2 Al+Cd; 10 mg/kg of AlCl3 and 1.5 mg/Kg of CdCl2. Treatment was done from pregnancy days (PNT) 7–20. After delivery, male animals were weaned on PSD 21 and sacrificed on PSD 78. From the study significant increases on serum liver enzymes in the
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Investigation of the effects of crocin on inflammation, oxidative stress, apoptosis, NF-κB, TLR-4 and Nrf-2/HO-1 pathways in gentamicin-induced nephrotoxicity in rats Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-19 Tuba Dogan, Betul Apaydin Yildirim, Kubra Asena Terim Kapakin
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Erythrocyte alterations in specimens of Danio rerio caused by exposure to metformin Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-18 Pablo Americo Barbieri, Luara Lupepsa, Brennda Ribeiro Paupitz, Camila Oliveira de Andrade, Adriana Aparecida Sinópolis Gigliolli, Ana Luiza de Brito Portela-Castro, Ricardo Pereira Ribeiro, Carlos Alexandre Fernandes, Luciana Andreia Borin-Carvalho
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Amitriptyline ecotoxicity in Danio rerio (Hamilton, 1822) embryos – similar toxicity profile in the presence of nanoplastics Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-18 Joana Santos, Angela Barreto, Teresa Coelho, Edna Carvalho, Diogo Pereira, Vânia Calisto, Vera L. Maria
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Assessment of thimerosal effects in sublethal concentrations on zebrafish (Danio rerio) embryos exploring NMR-based metabolomics profile Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-09 Edmilson Rodrigues da Rocha Junior, Viviane Amaral Porto, Alessandre Carmo Crispim, Jeferson Santana Ursulino, Lázaro Wender Oliveira de Jesus, Edson de Souza Bento, Josué Carinhanha Caldas Santos, Thiago Mendonça de Aquino
Thimerosal, a preservative commonly used in the pharmaceutical and cosmetic industry, has raised concerns regarding its potentially toxic effects as an organic mercury compound. Within this context, using an NMR-based metabolomics profile and chemometric analysis, zebrafish embryos were used as an in vivo model to study the effects of thimerosal in metabolic profiles after exposure to sublethal concentrations
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Haematological, biochemical, enzymological changes and mitochondrial dysfunction of liver in freshwater climbing perch Anabas testudineus during their acute and chronic exposure to sodium fluoride Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-02 Nimai Chandra Saha, Priyajit Banerjee, Arnab Chatterjee, Ritwick Bhattacharya, Shubhajit Saha, Paolo Pastorino