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RNA-editing drugs advance into clinical trials Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-18
ADAR-based editors that can change the mRNA code offer new opportunities in both rare genetic diseases and common complex ones.
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Three-step cures for autoimmune diseases? Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-17
Robert Plenge, head of Research at Bristol Myers Squibb, discusses his vision of sequential immunotherapy for autoimmune diseases — including multiple sclerosis.
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The antibody–drug conjugate landscape Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-16
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Targeting immunogenic cell stress and death for cancer therapy Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-15 Lorenzo Galluzzi, Emma Guilbaud, Darby Schmidt, Guido Kroemer, Francesco M. Marincola
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FDA new drug approvals in Q1 2024 Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-12
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Small molecule improves muscle function in myasthenia gravis Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-11
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FDA approves first complement factor D inhibitor Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-11
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FDA approves an HDAC inhibitor for Duchenne muscular dystrophy Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-11
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Non-antibiotic drug network reveals new leads for antibiotics Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-09
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Antibody drug conjugate combats inflammation Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-04
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PROTAC induces HIV-1 Nef degradation Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-04
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Sterol analogue suppresses hedgehog signalling Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-04
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Restoring a youthful immune system Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-04
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RNAi-based drug design: considerations and future directions Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-03 Qi Tang, Anastasia Khvorova
More than 25 years after its discovery, the post-transcriptional gene regulation mechanism termed RNAi is now transforming pharmaceutical development, proved by the recent FDA approval of multiple small interfering RNA (siRNA) drugs that target the liver. Synthetic siRNAs that trigger RNAi have the potential to specifically silence virtually any therapeutic target with unprecedented potency and durability
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The landscape of small-molecule prodrugs Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-02 Zachary Fralish, Ashley Chen, Shaharyar Khan, Pei Zhou, Daniel Reker
Prodrugs are derivatives with superior properties compared with the parent active pharmaceutical ingredient (API), which undergo biotransformation after administration to generate the API in situ. Although sharing this general characteristic, prodrugs encompass a wide range of different chemical structures, therapeutic indications and properties. Here we provide the first holistic analysis of the current
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Novel drug targets in 2023 Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-04-02
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FDA approves gene therapy for metachromatic leukodystrophy, the tenth for a genetic disease and the priciest yet Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-28
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Kinase inhibitor rescues the liver Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-28
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FDA approves Merck & Co’s pulmonary arterial hypertension drug sotatercept Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-27
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AI serves up target and inhibitor for lung fibrosis Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-20
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Genome-editing medicinal products: the EMA perspective Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-15
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NASH field celebrates ‘hurrah moment’ with a first FDA drug approval for the liver disease Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-14
Madrigal’s resmetirom has scored a landmark FDA win, bolstering hopes for a diverse pipeline of drugs for non-alcoholic steatohepatitis.
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Upcoming market catalysts in Q2 2024 Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-13
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Engineered T cells call for back-up Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-12
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The European Innovation Network as a hub for medicines innovation in Europe Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-11 Eleonora Agricola, Caroline Auriche-Benichou, Helena Baiao, Oriane Blanquie, Teodora Bodea, Tomáš Boráň, John-Joseph Borg, Valentina Cordo’, Maria Di Marzo, Lars Dmowski Rugholm, Falk Ehmann, Rúna Hauksdóttir Hvannberg, Ralf Herold, Alar Irs, Simona Jurkovič Mlakar, Robert Klaus, Juha Kolehmainen, Christophe Lahorte, Wiebke Löbker, Anna Mäkinen Salmi, Yoana Nuevo Ordoñez, Laurence O’Dwyer, Anna Maria
The European Innovation Network is working to support the European medical innovation ecosystem by facilitating early dialogue between developers of medicines and regulators, as well as providing a platform for regulators to share information, good practices and expertise.
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Shifts in the clinical trial landscape Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-08
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GSK’s first-in-class antibiotic secures another phase III win, approaches regulatory run Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-08
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Ribosome-targeted antibiotic tackles antimicrobial resistance Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-06
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Top companies and drugs by sales in 2023 Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-08
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Suppressing tumour Treg cells with a histone demethylase inhibitor Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-07
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Increasing the potency of T cell therapies Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-06
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Targeting proteins with bivalent glues Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-06
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Making macrophages with anti-tumour activity Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-06
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MYC inhibitor achieves phase I success Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-06
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The present and future of bispecific antibodies for cancer therapy Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-06 Christian Klein, Ulrich Brinkmann, Janice M. Reichert, Roland E. Kontermann
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Monkeypox mRNA vaccine protects mice and macaques Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-04
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From basic research to budding biotechs, under one roof with Stuart Schreiber Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-03-01
Stuart Schreiber discusses his plans to tackle inefficiencies in the translation of biomedical research, through the newly launched for-profit institute Arena BioWorks.
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Therapeutic developments for tuberculosis and nontuberculous mycobacterial lung disease Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-28 Véronique Dartois, Thomas Dick
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Opportunities and challenges for innovative and equitable healthcare Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-26 David J. Ecker, Clarice D. Aiello, Joseph R. Arron, C. Frank Bennett, Amy Bernard, Xandra O. Breakefield, Timothy J. Broderick, Shawneequa L. Callier, Barry Canton, Janice S. Chen, C. Simone Fishburn, Banning Garrett, Sidney M. Hecht, Tobias Janowitz, Melinda Kliegman, Adrian Krainer, Chrystal U. Louis, Christopher Lowe, Alfica Sehgal, Yesim Tozan, Kevin J. Tracey, Fyodor Urnov, Daniel Wattendorf,
An unprecedented number of potentially disruptive therapeutic technologies are under development. Forward-looking policies, incentives and infrastructure are needed to harness these advances to provide effective and globally equitable healthcare.
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FDA approves first tumour-infiltrating lymphocyte (TIL) therapy, bolstering hopes for cell therapies in solid cancers Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-19
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When can AI deliver the drug discovery hits? Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-19
The CACHE hit-finding competition highlights the potential of AI to identify small molecules that bind to hard-to-drug targets — and the long road ahead for these computational screening approaches.
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Approvals by the China NMPA in 2023 Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-19
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New NIH director’s research agenda spans “the laboratory, the clinic and the community” Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-19
Monica Bertagnolli, the newly appointed director of the NIH, discusses diversity, inclusion and access to biomedical research.
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Vertex’s non-opioid painkiller passes phase III tests Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-12
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Sanofi buys Inhibrx and drug for alpha-1 antitrypsin deficiency for US$1.7 billion Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-12
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BMP9 stands up to sepsis Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-12
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Novartis bets US$2.9 billion on MorphoSys and an anti-myelofibrosis drug Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-12
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BTK degraders tackle drug resistance Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-09
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The colorectal cancer drug market Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-09
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SLC15A4 inhibitor blocks inflammation Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-07
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i-shaped antibodies achieve receptor agonism Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-07
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Improving liquid biopsy for cancer detection Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-07
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Brain glucose mediates amphotericin B tolerance Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-07
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The Bespoke Gene Therapy Consortium: facilitating development of AAV gene therapies for rare diseases Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-06 P. J. Brooks, Timothy M. Miller, Frédéric Revah, Junghae Suh, Bradley R. Garrison, Lawrence C. Starke, Timothy K. MacLachlan, Edward G. Neilan, Gopa Raychaudhuri, Sadik H. Kassim, Jean Dehdashti, Joni L. Rutter
A public–private consortium established by the FNIH aims to address biological, manufacturing and regulatory challenges to the development of gene therapies for rare diseases.
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Macrocyclic peptides thwart Gram-negative bacteria Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-02-05
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Bispecific antibody boosts dendritic cell–T cell crosstalk Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-01-31
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The pipeline and market for psoriasis drugs Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-01-31
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Open science in precision medicine for neurodegenerative diseases Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-01-29 Hampton L. Leonard, Mike A. Nalls, Aaron Day-Williams, Sahar Esmaeeli, Paige Jarreau, Sara Bandres-Ciga, Peter Heutink, Pablo Sardi, Andrew B. Singleton
Open science initiatives that harness human genomic and genetic data could help increase the likelihood of successfully developing new drugs for neurodegenerative diseases.
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Membrane transporters in drug development and as determinants of precision medicine Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-01-24 Aleksandra Galetin, Kim L. R. Brouwer, Donald Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J. Hafey, Yurong Lai, Pär Matsson, Andrew Riselli, Hong Shen, Alex Sparreboom, Manthena V. S. Varma, Jia Yang, Xinning Yang, Sook Wah Yee, Maciej J. Zamek-Gliszczynski, Lei Zhang, Kathleen M. Giacomini
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Strategies to reduce the risks of mRNA drug and vaccine toxicity Nat. Rev. Drug. Disc. (IF 120.1) Pub Date : 2024-01-23 Dimitrios Bitounis, Eric Jacquinet, Maximillian A. Rogers, Mansoor M. Amiji