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Use of Chitosan as a Precursor for Multiple Applications in Medicinal Chemistry: Recent Significant Contributions Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-03-19 Diego Quiroga, Carlos Coy-Barrera
:: Chitosan (CS) is a polymer made up of mainly deacetylated β-1,4 D-glucosamine units, which is part of a large group of D-glucosamine oligomers known as chitooligosaccharides, which can be obtained from chitin, most abundant natural polymer after cellulose and central component of the shrimp exoskeleton. It is known that it can be used for the development of materials, among which its use stands
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Tanshinone IIA Against Cerebral Ischemic Stroke and Ischemia-Reperfusion Injury: A Review of the Current Documents Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-03-14 Reza Arefnezhad, Alireza Nejabat, Fatemeh Behjati, Mona Torkamanche, Hooman Zarei, Motahhareh Yekkehbash, Fatemeh Afsharmanesh, Zahra Niknam, Tannaz Jamialahmadi, Amirhossein Sahebkar
:: Stroke is a well-known neurological disorder that carries significant morbidity and mortality rates worldwide. Cerebral Ischemic Stroke (CIS), the most common subtype of stroke, occurs when thrombosis or emboli form elsewhere in the body and travel to the brain, leading to reduced blood perfusion. Cerebral Ischemia/Reperfusion Injury (CIRI) is a common complication of CIS and arises when blood flow
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Advances in the Synthesis and Bioactivity of Polysaccharide Selenium Nanoparticles: A Review Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-03-01 Shiying Ye, Shaowei Sun, Jiye Cai, Jinhuan Jiang
: Selenium, an essential trace element of the human body, is pivotal in human health and disease prevention. Nevertheless, the narrow therapeutic index of selenium, where the toxic and therapeutic doses are close, limits its clinical utility. Significantly, nanoscale selenium synthesized by different methods using polysaccharides as stabilizers has low toxicity properties and exhibits excellent bioactivity
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The Emergence of N. sativa L. as a Green Antifungal Agent Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-02-27 Raghvendra Pandey, Brijesh Pandey, Atul Bhargava
Background:: Nigella sativa L. has been widely used in the Unani, Ayurveda, Chinese, and Arabic medicine systems and has a long history of medicinal and folk uses. Several phytoconstituents of the plant are reported to have excellent therapeutic properties. In-vitro and in-vivo studies have revealed that seed oil and thymoquinone have excellent inhibitory efficacy on a wide range of both pathogenic
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Mini-Review on Vitamin D in Pediatric Population and its Role in Respiratory and Atopic Disorders Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-02-22 Cristiana Indolfi, Angela Klain, Giulio Dinardo, Fabio Decimo, Maria Maddalena Marrapodi, Amelia Licari, Michele Miraglia del Giudice
: In recent years, our comprehension of the function of vitamin D has significantly evolved. The ubiquitous presence of the vitamin D receptor (Vitamin D Receptor- VDR) in the body has led to its redefinition from a steroidal hormone primarily involved in skeletal functions to a hormone with pleiotropic effects, exerting its influence on the circulatory, nervous, and immune systems. This has prompted
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Dietary Plant Metabolites Induced Epigenetic Modification as a Novel Strategy for the Management of Prostate Cancer Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-02-22 Vaibhav Singh, Ekta Shirbhate, Rakesh Kore, Aditya Mishra, Varsha Johariya, Ravichandran Veerasamy, Amit K Tiwari, Harish Rajak
: Prostate cancer is a widespread malignancy among men, with a substantial global impact on morbidity and mortality. Despite advances in conventional therapies, the need for innovative and less toxic treatments remains a priority. Emerging evidence suggests that dietary plant metabolites possess epigenetic-modifying properties, making them attractive candidates for prostate cancer treatment. The present
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Targeting Lysosomes: A Strategy Against Chemoresistance in Cancer Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-02-12 Ekta Shirbhate, Vaibhav Singh, Aditya Mishra, Varsha Jahoriya, Ravichandran Veerasamy, Amit K Tiwari, Harish Rajak
: Chemotherapy is still the major method of treatment for many types of cancer. Curative cancer therapy is hampered significantly by medication resistance. Acidic organelles like lysosomes serve as protagonists in cellular digestion. Lysosomes, however, are gaining popularity due to their speeding involvement in cancer progression and resistance. For instance, weak chemotherapeutic drugs of basic nature
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Dendrobine: A neuroprotective Sesquiterpenic Alkaloid for the Prevention and Treatment of Diseases: A Review Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-02-07 Kanchan Bhardwaj, Rashi Bhargav, Jiri Patocka, Ruchi Sharma, Zdenka Navratilova, Patrik Oleksak, Kamil Kuca
: A sesquiterpenic alkaloid dendrobine is the major bioactive compound extracted from Dendrobium nobile Lindl. This compound was structurally very similar to picrotoxinin (neurotoxin) containing bicyclic or tricyclic ring while dendrobine containing tetracyclic rings with up to 7 stereogenic centers showing numerous neuroprotective effects. Several sesquiterpenic alkaloids such as (+)-(1R,5R,6S,8R
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The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex® - A Cannabis-derived Spray Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-02-06 Sina Motamedy, Bahare soltan, Halimeh Kameshki, Asmae Alipour kermani, Reza Saboori Amleshi, Masoud Nazeri, Mohammad Shabani
: Sativex is a cannabis-based medicine that comes in the form of an oromucosal spray. It contains equal amounts of Δ9-tetrahydrocannabinol and cannabidiol, two compounds derived from cannabis plants. Sativex has been shown to have positive effects on symptoms of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and sleep disorders. It also has analgesic, antiinflammatory, antitumoral, and
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Role of TBK1 Inhibition in Targeted Therapy of Cancer Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-02-05 Xueqing Yang, Zongliang Liu
: TANK-binding kinase 1 (TBK1) is a serine/threonine protein that plays a crucial role in various biological processes like immunity, autophagy, cell survival, and proliferation. The level and kinase activity of the TBK1 protein is regulated through post-translational modifications (PTMs). TBK1 mainly mediates the activation of IRF3/7 and NF-κB signaling pathways while also participating in the regulation
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Targeting STAT3 Enzyme for Cancer Treatment Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-02-01 Sowmiya Arun, Praveen Kumar Patel, Kaviarasan Lakhmanan, Rajangopal Kalirajan, Gowramma Byran
: A category of cytoplasmic transcription factors called STATs mediates intracellular signaling, which is frequently generated at receptors on cell surfaces and subsequently sent to the nucleus. STAT3 is a member of a responsible for a variety of human tumor forms, including lymphomas, hematological malignancies, leukemias, multiple myeloma and several solid tumor types. Numerous investigations have
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Targeting Ferroptosis: A Novel Strategy for the Treatment of Atherosclerosis Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-29 Yifan Zhang, Chengshi Jiang, Ning Meng
: Since ferroptosis was reported in 2012, its application prospects in various diseases have been widely considered, initially as a treatment direction for tumors. Recent studies have shown that ferroptosis is closely related to the occurrence and development of atherosclerosis. The primary mechanism is to affect the occurrence and development of atherosclerosis through intracellular iron homeostasis
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Anthriscus sylvestris: An overview on Bioactive Compounds and Anticancer Mechanisms from a Traditional Medicinal Plant to Modern Investigation Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-29 Mengyu Zhang, Xiaoyun Ji, Yuxin Li, Xin Chen, Xiaoqing Wu, Rui Tan, Hezhong Jiang
: Anthriscus sylvestris (L.) Hoffm. Gen. is a biennial or perennial herb commonly found in China. It has a long history of use in traditional Chinese medicine to treat various ailments such as cough, gastric disorders, spleen deficiency, and limb weakness. Recently, its potential as an anticancer agent has gained considerable attention and has been the subject of extensive research focusing on extract
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In silico Approaches for Exploring the Pharmacological Activities of Benzimidazole Derivatives: A Comprehensive Review Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-29 Manisha Srivastava, Kuldeep Singh, Sanjay kumar, Syed Misbahul Hasan, samar mujeeb, Somprakash Kushwaha, Ali Husen
Background: This article reviews computational research on benzimidazole derivatives. Cyotoxicity for all compounds against cancer cell lines was measured and the results revealed that many compounds exhibited high inhibitions. This research examines the varied pharmacological properties like anticancer, antibacterial, antioxidant, anti-inflammatory and anticonvulsant activities of benzimidazole derivatives
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Calcium Modulating Effect of Polycyclic Cages: A Suitable Therapeutic Approach Against Excitotoxic-induced Neurodegeneration Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-25 Ayodeji O. Egunlusi, Sarel F. Malan, Vitalii A. Palchykov, Jacques Joubert
: Neurodegenerative disorders pose a significant challenge to global healthcare systems due to their progressive nature and the resulting loss of neuronal cells and functions. Excitotoxicity, characterized by calcium overload, plays a critical role in the pathophysiology of these disorders. In this review article, we explore the involvement of calcium dysregulation in neurodegeneration and neurodegenerative
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SMAC Mimetics for the Treatment of Lung Carcinoma: Present Development and Future Prospects Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-25 Ruchi Pandey, Priya Bisht, Pranay Wal, Krishna Murti, V. Ravichandiran, Nitesh Kumar
Background: Uncontrolled cell growth and proliferation, which originate from lung tissue often lead to lung carcinoma and are more likely due to smoking as well as inhaled environmental toxins. It is widely recognized that tumour cells evade the ability of natural programmed death (apoptosis) and facilitates tumour progression and metastasis. Therefore investigating and targeting the apoptosis pathway
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A Review on Chemical Structures and Biological Activities of Dopamine Derivatives from Medicinal Insects Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-25 Wen-Jun Wei, Dong-Ge Wang, Meng-Shan Ji, Tao Guo
: Medicinal insects play an important role in the treatment of refractory diseases due to their unique and rich pharmacological activities. However, compared to plants, microorganisms, and marine organisms, medicinal insects have been largely ignored. Some small molecules isolated from insects are known to have defensive effects, but their majority roles remain unknown. In-depth research on the small
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Bioactivities and Structure-Activity Relationships of Usnic Acid Derivatives: A Review Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-24 Wen-Zhe Nie, Qing-Kun Shen, Zhe-Shan Quan, Hong-Yan Guo, Ya-Mei Li
: Usnic acid has a variety of biological activities, and has been widely studied in the fields of antibacterial, immune stimulation, antiviral, antifungal, anti-inflammatory and antiparasitic. Based on this, usnic acid is used as the lead compound for structural modification. In order to enhance the biological activity and solubility of usnic acid, scholars have carried out a large number of structural
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Roles of Accelerated Molecular Dynamics Simulations in Predictions of Binding Kinetic Parameters Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-24 Jianzhong Chen, Wei Wang, Haibo Sun, Weikai He
: Rational predictions on binding kinetics parameters of drugs to targets play significant roles in future drug designs. Full conformational samplings of targets are requisite for accurate predictions of binding kinetic parameters. In this review, we mainly focus on the applications of enhanced sampling technologies in calculations of binding kinetics parameters and residence time of drugs. The methods
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Targeted Inhibition of the PI3K/Akt/mTOR Signaling Axis: Potential for Sarcoma Therapy Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-24 Atif Khurshid Wani, Reena Singh, Nahid Akhtar, Ajit Prakash, Eugenie Nepovimova, Patrik Oleksak, Zofia Chrienova, Suliman Alomar, Chirag Chopra, Kamil Kuca
: Sarcoma is a heterogeneous group of malignancies often resistant to conventional chemotherapy and radiation therapy. The phosphatidylinositol-3-kinase/ protein kinase B /mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway has emerged as a critical cancer target due to its central role in regulating key cellular processes such as cell growth, proliferation, survival, and metabolism. Dysregulation
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The Search for Antidotes Against Ricin Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-24 Fernanda Diniz Botelho, Tanos Celmar Costa Franca, Steven R. LaPlante
The castor plant (Ricinus communis) is primarily known for its seeds, which contain a unique fatty acid called ricinoleic acid with several industrial and commercial applications. Castor seeds also contain ricin, a toxin considered a chemical and biological warfare agent. Despite years of investigation, there is still no effective antidote or vaccine available. However, some progress has been made
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Enhanced Sampling in Molecular Dynamics Simulations: How Many MD Snapshots can be Needed to Reproduce the Biological Behavior? Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-23 Camila A. Tavares, Taináh M.R. Santos, Mateus A. Gonçalves, Elaine F.F. da Cunha, Teodorico C. Ramalho
: Since its early days in the 19th century, medicinal chemistry has concentrated its efforts on the treatment of diseases, using tools from areas such as chemistry, pharmacology, and molecular biology. The understanding of biological mechanisms and signaling pathways is crucial information for the development of potential agents for the treatment of diseases mainly because they are such complex processes
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Artificial Intelligence in Drug Discovery: A Bibliometric Analysis and Literature Review Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-21 Baoyu He, Jingjing Guo, Henry H.Y. Tong, Wai Ming To
: Drug discovery is a complex and iterative process, making it ideal for using artificial intelligence (AI). This paper uses a bibliometric approach to reveal AI's trend and underlying structure in drug discovery (AIDD). A total of 4310 journal articles and reviews indexed in Scopus were analyzed, revealing that AIDD has been rapidly growing over the past two decades, with a significant increase after
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An In Silico Approach to Exploring the Antinociceptive Biological Activities of Linalool and its Metabolites Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-21 Pablo Rayff da Silva, Natalia Diniz Nunes Pazos, Jéssica Cabral de Andrade, Natália Ferreira de Sousa, Hugo Fernandes Oliveira Pires, Jaislânia Lucena de Figueiredo Lima, Arthur Lins Dias, Mirian Graciela da Silva Stiebbe Salvadori, Adriana Maria Fernandes de Oliveira Golzio, Ricardo Dias de Castro, Marcus T. Scotti, Vaishali M. Patil, Cícero Francisco Bezerra Felipe, Reinaldo Nóbrega de Almeida, Luciana
: Pain is characterized by the unpleasant sensory and emotional sensation associated with actual or potential tissue damage, whereas nociception refers to the mechanism by which noxious stimuli are transmitted from the periphery to the CNS. The main drugs used to treat pain are nonsteroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics, which have side effects that limit their use. Therefore
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Ferroptosis is Involved in the Pharmacological Effect of Ginsenoside Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2024-01-12 Juling Feng, Haodong Chen, Yangbo Liu, Qidi Ai, Yantao Yang, Wenbin He, Lei Zhao, Shifeng Chu, Naihong Chen
: Ginsenoside is the principal active ingredient in ginseng. Several investigations have found that ginsenosides have anti-inflammatory, antioxidant, anti-apoptotic, anti-cancer, and antiallergic activities. Ferroptosis is an iron-dependent, non-apoptotic form of cell-regulated death caused by lipid peroxidation. Iron, lipid, and amino acid metabolism orchestrate the complex ferroptosis response through
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Role of Flavonoids in Modulation of Mitochondria Dynamics during Oxidative Stress Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-12-27 Sachindra Kumar, Vishal Chhabra, Smita Shenoy, Rajni Daksh, Velayutham Ravichandiran, Ravindra Swamy, Nitesh Kumar
Background: Flavonoids are a widespread category of naturally occurring polyphenols distinguished by the flavan nucleus in plant-based foods and beverages, known for their various health benefits. Studies have suggested that consuming 150-500 mg of flavonoids daily is beneficial for health. Recent studies suggest that flavonoids are involved in maintaining mitochondrial activity and preventing impairment
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Mitochondrial Dysfunction and Imeglimin: A New Ray of Hope for the Treatment of Type-2 Diabetes Mellitus Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-12-27 Jayshree Swain, Pooja Jadhao, S. L. Sravya, Brij Teli, Kasukurti Lavanya, Jaspreet Singh, Abhay Sahoo, Srijit Das
: Diabetes is a rapidly growing health challenge and epidemic in many developing countries, including India. India, being the diabetes capital of the world, has the dubious dual distinction of being the leading nations for both undernutrition and overnutrition. Diabetes prevalence has increased in both rural and urban areas, affected the younger population and increased the risk of complications and
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Alzheimer's Disease and Cancer: Common Targets Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-12-01 Xueqing Yang, Jinlian Dai, Chenglong Wu, Zongliang Liu
: There is growing epidemiologic evidence of an inverse association between cancer and AD. In addition, both cell survival and death are regulated by the same signaling pathways, and their abnormal regulation may be implicated in the occurrence and development of cancer and AD. Research shows that there may be a common molecular mechanism between cancer and AD. This review will discuss the role of
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Mitochondrial Proteins as Metabolic Biomarkers and Sites for Therapeutic Intervention in Primary and Metastatic Cancers Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-11-30 Diana Xochiquetzal Robledo-Cadena, Silvia Cecilia Pacheco-Velazquez, Jorge Luis Vargas-Navarro, Joaquín Alberto Padilla-Flores, Rafael Moreno-Sanchez, Sara Rodríguez-Enríquez
: Accelerated aerobic glycolysis is one of the main metabolic alterations in cancer, associated with malignancy and tumor growth. Although glycolysis is one of the most studied properties of tumor cells, recent studies demonstrate that oxidative phosphorylation (OxPhos) is the main ATP provider for the growth and development of cancer. In this last regard, the levels of mRNA and protein of OxPhos enzymes
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A Literature Review Focusing on the Antiviral Activity of [1,2,4] and [1,2,3]-triazoles Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-11-27 Thoraya A. Farghaly, Ghada S. Masaret, Sayed M. Riyadh, Marwa F. Harras
: Out of a variety of heterocycles, triazole scaffolds have been shown to play a significant part in a wide array of biological functions. Many drug compounds containing a triazole moiety with important antimicrobial, anticancer and antidepressant properties have been commercialized. In addition, the triazole scaffold exhibits remarkable antiviral activity either incorporated into nucleoside analogs
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In Silico Pharmacokinetics, Molecular Docking and Molecular Dynamics Simulation Studies of Nucleoside Analogs for Drug Discovery- A Mini Review Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-11-14 Sarkar M. A. Kawsar, Nasrin S. Munia, Supriyo Saha, Yasuhiro Ozeki
: Nucleoside analogs have been widely used as antiviral, antitumor, and antiparasitic agents due to their ability to inhibit nucleic acid synthesis. Adenosine, cytidine, guanosine, thymidine and uridine analogs such as didanosine, vidarabine, remdesivir, gemcitabine, lamivudine, acyclovir, abacavir, zidovusine, stavudine, and idoxuridine showed remarkable anticancer and antiviral activities. In our
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Research Mechanism and Progress of the Natural Compound Curcumin in Treating Alzheimer´s Disease Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-11-06 Li Li, Fan Wang, Xirong Jia, Luyang Yao, Yu Liu
: Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. AD patients usually present symptoms, such as cognitive dysfunction, progressive memory loss, and other manifestations. With the increasing number of AD cases worldwide, there is an urgent need to develop effective drug treatments. Currently, drugs targeting AD symptoms may not change or prevent the progression of the
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Therapeutic Approaches for the Treatment of Interstitial Lung Disease: An Exploratory Review on Molecular Mechanisms Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-11-02 Revati Amin, Ruchi Pandey, K. Vaishali, Vishak Acharya, Mukesh Kumar Sinha, Nitesh Kumar
Background: Interstitial Lung Diseases (ILDs) are characterized by shortness of breath caused by alveolar wall inflammation and/or fibrosis. Objective: Our review aims to study the depth of various variants of ILD, diagnostic procedures, pathophysiology, molecular dysfunction and regulation, subject and objective assessment techniques, pharmacological intervention, exercise training and various modes
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Recent Development of DNA Gyrase Inhibitors: An Update Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-11-01 Poonam Piplani, Ajay kumar, Akanksha Kulshreshtha, Tamanna Vohra, Vritti Piplani
: Antibiotic or antimicrobial resistance is an urgent global public health threat that occurs when bacterial or fungal infections do not respond to the drug regimen designed to treat these infections. As a result, these microbes are not evaded and continue to grow. Antibiotic resistance against natural and already-known antibiotics like Ciprofloxacin and Novobiocin can be overcome by developing an
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Recent Methods for the Synthesis of Quinoxaline Derivatives and their Biological Activities Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-27 Thoraya A. Farghaly, Raghad M. Alqurashi, Ghada S. Masaret, Hanan Gaber Abdulwahab
: Quinoxaline derivatives have been incorporated into numerous marketed drugs used for the treatment of various diseases. Examples include glecaprevir (Mavyret), voxilaprevir (Vosevi), Balversa (L01EX16) (erdafitinib), carbadox, XK469R (NSC698215), and becampanel (AMP397). These quinoxaline derivatives exhibit a diverse range of pharmacological activities, including antibacterial, antitubercular, antiviral
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Flavonoid-metal ion Complexes as Potent Anticancer metallodrugs: A comprehensive Review Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-23 S.B. Zangade, B.S. Dhulshette, P.B. Patil
Background: Flavonoids and their analogous are mainly found in pink lady apples, green and black tea (catechins), celery and red peppers, onions, broccoli and spinach, berries, cherries, soybean, citrus fruits, and fungi. The different derivatives of flavonoids belonging to polyphenolic compounds such as 3,4′,5,7-Tetrahydroxyflavylium (pelargonidin), 2-(3,4-Dihydroxyphenyl)chromenylium-3,5,7-triol
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Roles of lncRNA-MALAT1 in the Progression and Prognosis of Gliomas Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-15 Da-Peng Wang, Yu-Long Ji, Qiao-Li Lv, Kai Kang
: Long noncoding RNAs (lncRNAs) represent a large subgroup of RNA transcripts that lack the function of coding proteins and may be essential universal genes involved in carcinogenesis and metastasis. LncRNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNAMALAT1) is overexpressed in various human tumors, including gliomas. However, the biological function and molecular mechanism of action
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The Effects of Apigenin in the Treatment of Diabetic Nephropathy: A Systematic Review of Non-clinical Studies Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-15 Thikra Majid Muhammed, Abduladheem Turki Jalil, Waam Mohammed Taher, Zafar Aminov, Fahad Alsaikhan, Andrés Alexis Ramírez-Coronel, Pushpamala Ramaiah, Bagher Farhood
Purpose: Diabetes is one of the important and growing diseases in the world. Among the most common diabetic complications are renal adverse effects. The use of apigenin may prevent the development and progression of diabetes-related injuries. The current study aims to review the effects of apigenin in the treatment of diabetic nephropathy. Methods: In this review, a systematic search was performed
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A Comprehensive Review on Chemistry and Biology of Tafamidis in Transthyretin Amyloidosis Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-11 Monali B. Patil, Piyush Ghode, Prashant Joshi
Transthyretin amyloid cardiomyopathy and Transthyretin amyloid peripheral neuropathy are progressive disease conditions caused by Transthyretin amyloidosis (ATTR) fibril infiltration in the tissue. Transthyretin (TTR) protein misfolding and amyloid fibril deposits are pathological biomarkers of ATTR-related disorders. There are various treatment strategies targeting different stages in pathophysiology
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Cortisol as a Target for Treating Mental Disorders: A Promising Avenue for Therapy Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-10 Vijay Patel, Aayush Vaishnaw, Ekta Shirbhate, Rakesh Kore, Vaibhav Singh, Ravichandran Veerasamy, Harish Rajak
Cortisol, commonly known as the
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Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-10 Manish Chaudhary, Shubham Kumar, Paranjeet kaur, Sanjeev Kumar Sahu, Amit Mittal
Prostate cancer is a disease that is affecting a large population worldwide. Androgen deprivation therapy (ADT) has become a foundation for the treatment of advanced prostate cancer, as used in most clinical settings from neo-adjuvant to metastatic stage. In spite of the success of ADT in managing the disease in the majority of men, hormonal manipulation fails eventually. New molecules are developed
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Drug Delivery System Approaches for Rheumatoid Arthritis Treatment: A Review Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-09 Anushka Garhwal, Priyadarshi Kendya, Sakshi Soni, Shivam Kori, Vandana Soni, Sushil Kumar Kashaw
Rheumatoid arthritis (RA) is a chronic autoimmune disease that has traditionally been treated using a variety of pharmacological compounds. However, the effectiveness of these treatments is often limited due to challenges associated with their administration. Oral and parenteral routes of drug delivery are often restricted due to issues such as low bioavailability, rapid metabolism, poor absorption
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Recent Advances in Natural Products with Anti-Leukemia and Anti- Lymphoma Activities Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-06 Zhi-Gang Sun, Cheng-Jie Yao, Inam Ullah, Hai-Liang Zhu
Leukemia and lymphoma are the most common blood cancers, which pose a critical threat to the health of adults and children. The total incidence and mortality rates of both are approximately 6% globally. Compared with the expensive cost of CAR T cell therapy, natural products from animals, plants and microorganisms have the characteristics of wide-range sources and costeffectiveness in the treatment
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The Progress of Small Molecule Targeting BCR-ABL in the Treatment of Chronic Myeloid Leukemia Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-06 Yuan Zhang, Xin Wu, Xueyan Sun, Jun Yang, Chang Liu, Guotao Tang, Xiaoyong Lei, Honglin Huang, Junmei Peng Peng
Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease. According to the American Cancer Society's 2021 cancer data report, new cases of CML account for about 15% of all leukemias. CML is generally divided into three stages: chronic phase, accelerated phase, and blast phase. Nearly 90% of patients are diagnosed as a chronic phase. Allogeneic stem cell transplantation and chemotherapeutic
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HDAC9 as a Privileged Target: Reviewing its Role in Different Diseases and Structure-activity Relationships (SARs) of its Inhibitors Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-05 Totan Das, Samima Khatun, Tarun Jha, Shovanlal Gayen
HDAC9 is a histone deacetylase enzyme belonging to the class IIa of HDACs which catalyses histone deacetylation. HDAC9 inhibit cell proliferation by repairing DNA, arresting the cell cycle, inducing apoptosis, and altering genetic expression. HDAC9 plays a significant part in human physiological system and are involved in various type of diseases like cancer, diabetes, atherosclerosis and CVD, autoimmune
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The Role of Extracellular Vesicles in Efferocytosis Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-04 Susan Panahi, Zohreh Yazdi, Mahboubeh Sanchouli, Fatemehsadat Sajadi, Fateme Motavasselian, Hedyeh Maghareh Abed, Zahra Beygi, Seyed Mohammad Gheibihayat
Efferocytosis is the physiological process of phagocytic clearance of apoptotic cells by both professional phagocytic cells, such as macrophages, and non-professional phagocytic cells, such as epithelial cells. This process is crucial for maintaining tissue homeostasis in normal physiology. Any defects in efferocytosis can lead to pathological consequences and result in inflammatory diseases. Extracellular
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Natural and Synthetic Phosphodiesterase Inhibitors in 2023: an Update on the Impact on Neurological and Psychiatric Conditions Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-10-04 Giovanni Ribaudo, Alessandra Gianoncelli
This Perspective provides an updated overview on the involvement of phosphodiesterase (PDE) isoforms and of the corresponding inhibitors in neurological disorders, including dementia, Parkinson’s disease, multiple sclerosis, neuropsychiatric conditions and cerebral ischemia. Particular attention has been dedicated to natural and semi-synthetic compounds. Translation into the clinic of preclinical results
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Research Progress of Tamarixetin and its Glycosides Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-26 Cunbing Li, Mengxin Tao, Tingting Li, Xiaofen Huang, Hong Sui, Xueyan Fu
Tamarixetin and its glycosides are widely distributed in natural plants, and they are also natural flavonoid derivatives of quercetin. Its main pharmacological effects include antioxidant, antiinflammatory, antiviral, anticancer, cardiovascular effects, etc. The pharmacokinetics showed that the distribution of direct absorption differed from that of biosynthesis. At the same time, research shows that
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The Critical Function of microRNAs in Developing Resistance against 5- Fluorouracil in Cancer Cells Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-25 Farhad Sheikhnia, Hossein Maghsoudi, Maryam Majidinia
Although there have been significant advancements in cancer treatment, resistance and recurrence in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the suppression of
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DNA Methyltransferase 3A: A Significant Target for the Discovery of Inhibitors as Potent Anticancer Drugs Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-21 Qixun Feng, Honggao Duan, Xinglong Zhou, Yuning Wang, Jinda Zhang, Haoge Zhang, Guoliang Chen, Xuefei Bao
DNA methyltransferase (DNMT) is a conserved family of Cytosine methylases, which plays a crucial role in the regulation of Epigenetics. They have been considered promising therapeutic targets for cancer. Among the DNMT family, mutations in the DNMT3A subtype are particularly important in hematologic malignancies. The development of specific DNMT3A subtype inhibitors to validate the therapeutic potential
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Recent Advances in Nanobiotechnology for the Treatment of Non-Hodgkin’s Lymphoma Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-19 Shuxian Liu, Minghao Xu, Lei Zhong, Xiangmin Tong, Suying Qian
: Lymphoma is the eighth most common type of cancer worldwide. Currently, lymphoma is mainly classified into two main groups: Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL), with NHL accounting for 80% to 90% of the cases. NHL is primarily divided into B, T, and natural killer (NK) cell lymphoma. Nanotechnology is developing rapidly and has made significant contributions to the field of medicine
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Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and Utility in Combating SARS-COV-2 Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-15 Farak Ali, Shahnaz Alom, Sheikh Rezzak Ali, Biswanarayan kondoli, Prativa Sadhu, Chinmoyee Borah, Bibhuti Bushan Kakoti, Surajit Kumar Ghosh, Anshul Shakya, Abdul Baquee Ahmed, Udaya Pratap Singh, Hans Raj Bhatt
: Ebselen is a selenoorganic chiral compound with antioxidant properties comparable to glutathione peroxidase. It is also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one. In studies examining its numerous pharmacological activities, including antioxidant, anticancer, antiviral, and anti-Alzheimer’s, ebselen has demonstrated promising results. This review's primary objective was to emphasize the numerous
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Recent Advances in Xanthine Oxidase Inhibitors Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-14 Zhi-Gang Sun, Kai-Xiang Wu, Inam Ullah, Hai-Liang Zhu
: Uric acid is a product of purine nucleotide metabolism, and high concentrations of uric acid can lead to hyperuricemia, gout and other related diseases. Xanthine oxidase, the only enzyme that catalyzes xanthine and hypoxanthine into uric acid, has become a target for drug development against hyperuricemia and gout. Inhibition of xanthine oxidase can reduce the production of uric acid, so xanthine
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The most recent compilation of reactions of enaminone derivatives with various amine derivatives to generate biologically active compounds Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-14 Thoraya A. Farghaly, Amal M. Alosaimy, Nadia T. Al-Qurashi, Ghada S. Masaret, Hanan Gaber Abdulwahab
: Heterocyclic derivatives serve as the fundamental components of both natural and synthetic drugs. Enaminones play a crucial role as foundational units in the synthesis of numerous bioactive heterocyclic compounds, including pyrazoles, pyridines, oxazoles, isoxazoles, as well as fused heterocyclic structures like indoles, carbazoles, quinolines, acridines, and phenanthridines. These diverse heterocyclic
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Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-12 Ajita Paliwal, Vartika Paliwal, Smita Jain, Sarvesh Paliwal, Swapnil Sharma
The glucokinase regulator (GCKR) gene encodes an inhibitor of the glucokinase enzyme (GCK), found only in hepatocytes and responsible for glucose metabolism. A common GCKR coding variation has been linked to various metabolic traits in genome-wide association studies. Rare GCKR polymorphisms influence GKRP activity, expression, and localization. Despite not being the cause, these variations are linked
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Mechanism of Action of Collagen and Epidermal Growth Factor: A Review on Theory and Research Methods Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-12 Mohamad Hesam Shahrajabian, Wenli Sun
The most abundant protein found in mammals is collagen, and there are around 28 different types of collagen found in the human body, but there are five types, namely, Type I, Type II, Type III, Type V, and Type X, most generally applied in supplements, and the five common types of collagen are available in various forms and form different sources, which result in various potential benefits. The epidermal
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MiRNAs: Emerging Agents for Therapeutic Effects of Polyphenols on Ovarian Cancer Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-12 Bita Badehnoosh, Nesa Rajabpoor Nikoo, Reza Asemi, Rana Shafabakhsh, Zatollah Asemi
In terms of female reproductive tract cancers, ovarian cancer remains the principal reason for mortality globally and is notably difficult to identify in its early stages. This fact highlights the critical need to establish prevention strategies for patients with ovarian cancer, look for new robust diagnostic and prognostic markers, and identify potential targets of response to treatment. MicroRNAs
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Cinnamaldehyde as a Promising Dietary Phytochemical Against Metabolic Syndrome: A Systematic Review Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-12 Mohaddeseh Khaafi, Zahra Tayarani-Najaran, Behjat Javadi
Background: Metabolic syndrome (METS) is a set of unhealthy medical conditions considered essential health problems today. Cinnamaldehyde (CA) is the major phytochemical present in the essential oil of cinnamon and possesses antioxidant, anti-inflammatory, hypoglycemic, and antihyperlipidemic activities. Aim: We aim to systematically review the effects of CA in preventing and attenuating METS components
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Antimicrobial and cytotoxic naphthoquinones from microbial origin: An updated review Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-11 Marziyeh Esmaeilzadeh Kashi, Mahdiyeh ghanbari, Hasan Badibostan, Veronique Seidel, Seyed Hamzeh Hosseini, Javad Asili, Abolfazl Shakeri, Amirhossein Sahebkar
: Naphthoquinones (NQs) are small molecules bearing two carbonyl groups. They have been the subject of much research due to their significant biological activities such as antiproliferative, antimicrobial, anti-inflammatory, antioxidant, and antimalarial effects. NQs are produced mainly by bacteria, fungi and higher plants. Among them, microorganisms are a treasure of NQs with diverse skeletons and
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The Use of Nanocarriers to Enhance the Anti-neuroinflammatory Potential of Dietary Flavonoids in Animal Models of Neurodegenerative Diseases: A Systematic Review Mini-Rev. Med. Chem. (IF 3.8) Pub Date : 2023-09-11 Gopalsamy Rajiv Gandhi, Varghese Edwin Hillary, Kumaraswamy Athesh, Maria Letícia Carvalho da Cruz Ramos, Gabriela Peres de Oliveira Krauss, Gnanasekaran Jothi, Gurunagarajan Sridharan, Rengaraju Sivasubramanian, Govindasamy Hariharan, Alan Bruno Silva Vasconcelos, Monalisa Martins Montalvão, Stanislaus Antony Ceasar, Valdete Kaliane da Silva Calisto, Ricardo Queiroz Gurgel
Background: Neurodegenerative diseases (NDs) have become a common and growing cause of mortality and morbidity worldwide, especially in older adults. The natural flavonoids found in fruits and vegetables have been shown to have therapeutic effects against many diseases, including NDs; however, in general, flavonoids have limited bioavailability to the target cells. One promising strategy to increase