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COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit Antibiotics (IF 4.8) Pub Date : 2024-04-17 Mircea Stoian, Adina Andone, Alina Boeriu, Sergio Rareș Bândilă, Daniela Dobru, Sergiu Ștefan Laszlo, Dragoș Corău, Emil Marian Arbănași, Eliza Russu, Adina Stoian
Since the emergence of SARS-CoV-2 in late 2019, the global mortality attributable to COVID-19 has reached 6,972,152 deaths according to the World Health Organization (WHO). The association between coinfection with Clostridioides difficile (CDI) and SARS-CoV-2 has limited data in the literature. This retrospective study, conducted at Mureș County Clinical Hospital in Romania, involved 3002 ICU patients
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Antibacterial Activity of Oregano (Origanum vulgare L.) Essential Oil Vapors against Microbial Contaminants of Food-Contact Surfaces Antibiotics (IF 4.8) Pub Date : 2024-04-18 Loris Pinto, Salvatore Cervellieri, Thomas Netti, Vincenzo Lippolis, Federico Baruzzi
The antimicrobial effect of eight essential oils’ vapors against pathogens and spoilage bacteria was assayed. Oreganum vulgare L. essential oil (OVO) showed a broad antibacterial effect, with Minimum Inhibitory Concentration (MIC) values ranging from 94 to 754 µg cm−3 air, depending on the bacterial species. Then, gaseous OVO was used for the treatment of stainless steel, polypropylene, and glass surfaces
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Comparative Pharmacokinetics of Gentamicin C1, C1a and C2 in Healthy and Infected Piglets Antibiotics (IF 4.8) Pub Date : 2024-04-18 Eun-Young Kim, Tae-Won Kim, Elias Gebru Awji, Eon-Bee Lee, Seung-Chun Park
Gentamicin, an aminoglycoside antibiotic, is a mixture of therapeutically active C1, C1a, C2 and other minor components. Despite its decades-long use in pigs and other species, its intramuscular (IM) pharmacokinetics/pharmacodynamics (PKs/PDs) are unknown in piglets. Furthermore, the PKs of many drugs differ between healthy and sick animals. Therefore, we investigated the PKs of gentamicin after a
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Environmental and Nutritional Parameters Modulating Genetic Expression for Virulence Factors of Clostridioides difficile Antibiotics (IF 4.8) Pub Date : 2024-04-16 Zoe Masset, Sathursha Gunaratnam, Mathieu Millette, Lynne V. McFarland, Monique Lacroix
Clostridioides difficile infections (CDIs) continue to be a persistent healthcare concern despite newer antibiotic treatments, enhanced infection control practices, and preventive strategies focused on restoring the protective intestinal microbial barrier. Recent strides in gene sequencing research have identified many genes regulating diverse virulence factors for CDIs. These genes may be over- or
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Evaluating the Clinical Relevance of Routine Sonication for Periprosthetic Hip or Knee Joint Infection Diagnosis Antibiotics (IF 4.8) Pub Date : 2024-04-17 Anas Zouitni, Jakob van Oldenrijk, P. Koen Bos, Peter D. Croughs, Erlangga Yusuf, Ewout S. Veltman
Periprosthetic joint infection (PJI) is a serious complication after joint arthroplasty. PJI screening and conventional cultures may be inconclusive. Sonication fluid culturing stands out as a valuable adjunct technique for PJI diagnosis. This study aims to determine the clinical relevance of routine sonication for all (a)septic revisions. All patients who underwent (partial) hip or knee revision arthroplasty
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Medical-Grade Honey as a Potential New Therapy for Bacterial Vaginosis Antibiotics (IF 4.8) Pub Date : 2024-04-17 Céline M. J. G. Lardenoije, Senna J. J. M. van Riel, Linsey J. F. Peters, Martine M. L. H. Wassen, Niels A. J. Cremers
The prevalence of bacterial vaginosis (BV) among women of reproductive age is 29%. BV arises from a vaginal imbalance marked by reduced levels of lactic acid-producing lactobacilli and an overgrowth of pathogenic anaerobes. The multifactorial nature of BV’s pathogenesis complicates its treatment. Current antibiotic therapy exhibits a recurrence rate of about 60% within a year. Recurrence can be caused
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Antimicrobial, Probiotic, and Immunomodulatory Potential of Cannabis sativa Extract and Delivery Systems Antibiotics (IF 4.8) Pub Date : 2024-04-17 Anna Stasiłowicz-Krzemień, Daria Szymanowska, Piotr Szulc, Judyta Cielecka-Piontek
The compounds present in hemp show multidirectional biological activity. It is related to the presence of secondary metabolites, mainly cannabinoids, terpenes, and flavonoids, and the synergy of their biological activity. The aim of this study was to assess the activity of the Henola Cannabis sativae extract and its combinations with selected carriers (polyvinyl caprolactam–polyvinyl acetate–polyethylene
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Meta-Analysis and Systematic Review of Phenotypic and Genotypic Antimicrobial Resistance and Virulence Factors in Vibrio parahaemolyticus Isolated from Shrimp Antibiotics (IF 4.8) Pub Date : 2024-04-17 Varangkana Thaotumpitak, Justice Opare Odoi, Saran Anuntawirun, Saharuetai Jeamsripong
This systematic review and meta-analysis investigates the prevalence of Vibrio parahaemolyticus, its virulence factors, antimicrobial resistance (AMR), and its resistance determinants in shrimp. This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, to identify and select relevant peer-reviewed articles published between January
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Genomic Epidemiology of C2/H30Rx and C1-M27 Subclades of Escherichia coli ST131 Isolates from Clinical Blood Samples in Hungary Antibiotics (IF 4.8) Pub Date : 2024-04-16 Kinga Tóth, Ivelina Damjanova, Levente Laczkó, Lilla Buzgó, Virág Lesinszki, Erika Ungvári, Laura Jánvári, Adrienn Hanczvikkel, Ákos Tóth, Dóra Szabó
Extended-spectrum β-lactamase-producing Escherichia coli ST131 has become widespread worldwide. This study aims to characterize the virulome, resistome, and population structure of E. coli ST131 isolates from clinical blood samples in Hungary. A total of 30 C2/H30Rx and 33 C1-M27 ST131 isolates were selected for Illumina MiSeq sequencing and 30 isolates for MinION sequencing, followed by hybrid de
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Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA) Antibiotics (IF 4.8) Pub Date : 2024-04-16 Giuseppe Gancitano, Nicola Mucci, Rainer Stange, Mercedes Ogal, Selvarani Vimalanathan, Mahfuza Sreya, Anthony Booker, Bushra Hadj-Cherif, Werner C. Albrich, Karin Woelkart-Ardjomand, Samo Kreft, Wim Vanden Berghe, Godehard Hoexter, Andreas Schapowal, Sebastian L Johnston
Respiratory tract infections (RTIs) are the leading cause of antibiotic prescriptions, primarily due to the risk for secondary bacterial infections. In this study, we examined whether Echinacea could reduce the need for antibiotics by preventing RTIs and their complications, and subsequently investigated its safety profile. A comprehensive search of EMBASE, PubMed, Google Scholar, Cochrane DARE and
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Systemic Impact of Subgingival Infection Control in Periodontitis Patients with Cardiovascular Disease: A Narrative Review Antibiotics (IF 4.8) Pub Date : 2024-04-15 Carmen Silvia Caloian, Andreea Ciurea, Marius Negucioiu, Alexandra Roman, Iulia Cristina Micu, Andrei Picoș, Andrada Soancă
Introduction: Periodontitis, an infectious inflammatory condition, is a key contributor to sustained systemic inflammation, intricately linked to atherosclerotic cardiovascular disease (CVD), the leading cause of death in developed nations. Treating periodontitis with subgingival mechanical instrumentation with or without adjunctive antimicrobials reduces the microbial burden and local inflammation
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A Review of the Impact of Streptococcal Infections and Antimicrobial Resistance on Human Health Antibiotics (IF 4.8) Pub Date : 2024-04-15 Raina Gergova, Vasil Boyanov, Adile Muhtarova, Alexandra Alexandrova
Streptococcus pneumoniae, Streptococcus pyogenes (GAS), and Streptococcus agalactiae (GBS) are bacteria that can cause a range of infections, some of them life-threatening. This review examines the spread of antibiotic resistance and its mechanisms against antibiotics for streptococcal infections. Data on high-level penicillin-resistant invasive pneumococci have been found in Brazil (42.8%) and Japan
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How Useful Is Preoperative Aspiration before Revision of Unicompartmental Knee Prostheses Because of Osteoarthritis in the Other Compartments? Antibiotics (IF 4.8) Pub Date : 2024-04-15 Benedikt Paul Blersch, Florian Hubert Sax, Bernd Fink
Aim: Periprosthetic joint infections (PJIs) of unicompartmental knee arthroplasties (UKAs) can lead to secondary osteoarthritis of the other compartments. The objective of this study was to identify the frequency of PJIs in cases of UKA with progressed secondary osteoarthritis and the result of septic one-stage revision in these cases to verify the value of preoperative aspiration in cases of secondary
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A Mini-Review of Anti-Listerial Compounds from Marine Actinobacteria (1990–2023) Antibiotics (IF 4.8) Pub Date : 2024-04-15 Siyanda S. Ngema, Evelyn Madoroba
Among the foodborne illnesses, listeriosis has the third highest case mortality rate (20–30% or higher). Emerging drug-resistant strains of Listeria monocytogenes, a causative bacterium of listeriosis, exacerbate the seriousness of this public health concern. Novel anti-Listerial compounds are therefore needed to combat this challenge. In recent years, marine actinobacteria have come to be regarded
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Polyphenolic Composition and Antimicrobial, Antioxidant, Anti-Inflammatory, and Antihyperglycemic Activity of Different Extracts of Teucrium montanum from Ozren Mountain Antibiotics (IF 4.8) Pub Date : 2024-04-14 Pero Sailović, Božana Odžaković, Darko Bodroža, Jelena Vulić, Jasna Čanadanović-Brunet, Jelena Zvezdanović, Bojana Danilović
Teucrium montanum has widespread use in folk medicine on the Balkan peninsula. In order to scientifically justify this use, the composition and biological activity of aqueous, ethanol, and acetone extract were investigated in this study. Moreover, acetone and ethanol extracts were obtained from the plant material previously exhausted by water extraction. A total of 27 compounds were detected in extracts
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Pharmacokinetics and Nephrotoxicity of Polymyxin MRX-8 in Rats: A Novel Agent against Resistant Gram-Negative Bacteria Antibiotics (IF 4.8) Pub Date : 2024-04-12 Xingyi Qu, Chenxue Guo, Shaojun Liu, Xin Li, Lin Xi, Xiaofen Liu, Jing Zhang
MRX-8 is a novel polymyxin for carbapenem-resistant Gram-negative infections that has been recently evaluated in Phase I clinical trials. Herein, its pharmacokinetics (PK) and nephrotoxicity in rats are reported for the first time. This study aimed at pre-clinical PK and safety assessments. An LC-MS/MS method was developed to determine concentrations of MRX-8 and its major deacylation metabolite, MRX-8039
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Expression of Concern: Rahman et al. An Overview of Antimicrobial Stewardship Optimization: The Use of Antibiotics in Humans and Animals to Prevent Resistance. Antibiotics 2022, 11, 667 Antibiotics (IF 4.8) Pub Date : 2024-04-12 Antibiotics Editorial Office
With this notice, the Antibiotics Editorial Office states its awareness of concerns relating to the originality of the concepts and analysis published in this review [...]
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Pharmacokinetics of Enrofloxacin in Plasma, Urine, and Feces of Donkey (Equus asinus) after a Single Intragastric Administration Antibiotics (IF 4.8) Pub Date : 2024-04-12 Bowen Yang, Shijie Liu, Jie Cheng, Honglei Qu, Yanxin Guo, Chuanliang Ji, Yantao Wang, Shancang Zhao, Shimeng Huang, Lihong Zhao, Qiugang Ma
Enrofloxacin is a broad-spectrum antimicrobial agent, but the study of its pharmacokinetics/pharmacodynamics (PKs/PDs) in donkeys is rarely reported. The present study aimed to investigate the pharmacokinetics of enrofloxacin administered intragastrically, and to study the pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in plasma, urine, and feces, and the PK/PD parameters were investigated
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Antimicrobial Stewardship in the Emergency Department Observation Unit: Definition of a New Indicator and Evaluation of Antimicrobial Use and Clinical Outcomes Antibiotics (IF 4.8) Pub Date : 2024-04-12 Ana Belén Guisado-Gil, Marta Mejías-Trueba, Germán Peñalva, Manuela Aguilar-Guisado, Jose Molina, Adelina Gimeno, Rocío Álvarez-Marín, Julia Praena, Claudio Bueno, José Antonio Lepe, María Victoria Gil-Navarro, José Miguel Cisneros
We aimed to define a novel indicator for monitoring antimicrobial use specifically in the Emergency Department Observation Unit (EDOU) and to assess the long-term impact of an institutional education-based antimicrobial stewardship program (ASP) on the antimicrobial prescribing pattern and clinical outcomes in this setting. A quasi-experimental interrupted time-series study was performed from 2011
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Change in Diagnosis of Helicobacter pylori Infection in the Treatment-Failure Era Antibiotics (IF 4.8) Pub Date : 2024-04-12 Rocco Spagnuolo, Giuseppe Guido Maria Scarlata, Maria Rosaria Paravati, Ludovico Abenavoli, Francesco Luzza
Helicobacter pylori (H. pylori) infection is a prevalent global health issue, associated with several gastrointestinal disorders, including gastritis, peptic ulcers, and gastric cancer. The landscape of H. pylori treatment has evolved over the years, with increasing challenges due to antibiotic resistance and treatment failure. Traditional diagnostic methods, such as the urea breath test, stool antigen
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Antibiotics Prescribing Pattern and Quality of Prescribing in Croatian Dental Practices—5-Year National Study Antibiotics (IF 4.8) Pub Date : 2024-04-09 Lucija Petrac, Katarina Gvozdanovic, Vjera Perkovic, Nikolina Petek Zugaj, Neven Ljubicic
Purpose: Antibiotic resistance is one of the biggest threats to global health today. The aim of this study was to analyze antibiotic prescribing patterns and quality of prescribing in Croatian dental practices over a 5-year period. Methods: This is a retrospective observational study based on the analysis of the electronic prescriptions (medicines in ATC groups J01 and P01) from dental practices in
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Repurposing Farnesol for Combating Drug-Resistant and Persistent Single and Polymicrobial Biofilms Antibiotics (IF 4.8) Pub Date : 2024-04-11 Li Tan, Rong Ma, Tony Reeves, Adam J. Katz, Nicole Levi
Biofilm-associated infections caused by drug-resistant and persistent bacteria remain a significant clinical challenge. Here we report that farnesol, commercially available as a cosmetic and flavoring agent, shows significant anti-biofilm properties when dissolved in ethanol using a proprietary formulation emulsion technique. Farnesol in the new formulation inhibits biofilm formation and disrupts established
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Diagnostics in Late Periprosthetic Infections—Challenges and Solutions Antibiotics (IF 4.8) Pub Date : 2024-04-11 Florian Hubert Sax, Marius Hoyka, Benedikt Paul Blersch, Bernd Fink
The rising number of arthroplasties is combined with a rising number of periprosthetic joint infections, which leads to life-concerning consequences for the patients, including extended antibiotic treatment, further surgery and increased mortality. The heterogeneity of the symptoms and inflammatory response of the patients due to, e.g., age and comorbidities and the absence of a single diagnostic test
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Deciphering Microbiome, Transcriptome, and Metabolic Interactions in the Presence of Probiotic Lactobacillus acidophilus against Salmonella Typhimurium in a Murine Model Antibiotics (IF 4.8) Pub Date : 2024-04-11 Muhammad Junaid, Hongyu Lu, Ahmad Ud Din, Bin Yu, Yu Liu, Yixiang Li, Kefei Liu, Jianhua Yan, Zhongquan Qi
Salmonella enterica serovar Typhimurium (S. Typhimurium), a foodborne pathogen that poses significant public health risks to humans and animals, presents a formidable challenge due to its antibiotic resistance. This study explores the potential of Lactobacillus acidophilus (L. acidophilus 1.3251) probiotics as an alternative strategy to combat antibiotic resistance associated with S. Typhimurium infection
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Evolution of Resistance against Ciprofloxacin, Tobramycin, and Trimethoprim/Sulfamethoxazole in the Environmental Opportunistic Pathogen Stenotrophomonas maltophilia Antibiotics (IF 4.8) Pub Date : 2024-04-05 Luz Edith Ochoa-Sánchez, José Luis Martínez, Teresa Gil-Gil
Stenotrophomonas maltophilia is an opportunistic pathogen that produces respiratory infections in immunosuppressed and cystic fibrosis patients. The therapeutic options to treat S. maltophilia infections are limited since it exhibits resistance to a wide variety of antibiotics such as β-lactams, aminoglycosides, tetracyclines, cephalosporins, macrolides, fluoroquinolones, or carbapenems. The antibiotic
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In Vitro/Vivo Mechanisms of Antibacterial Peptide NZ2114 against Staphylococcus pseudintermedius and Its Biofilms Antibiotics (IF 4.8) Pub Date : 2024-04-08 Shuang Zhang, Na Yang, Ruoyu Mao, Ya Hao, Da Teng, Jianhua Wang
Staphylococcus pseudintermedius is an opportunistic pathogen commonly found in canines, and has garnered escalating interest due to its potential for zoonotic transmission and increasing antimicrobial resistance. However, the excessive use of antibiotics and the characteristic of S. pseudintermedius forming biofilms make treatment challenging. In this study, the in vivo and in vitro antimicrobial activity
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Antibiofilm and Immune-Modulatory Activity of Cannabidiol and Cannabigerol in Oral Environments—In Vitro Study Antibiotics (IF 4.8) Pub Date : 2024-04-09 Hernan Santiago Garzón, Manuela Loaiza-Oliva, María Cecilia Martínez-Pabón, Jenniffer Puerta-Suárez, Mayra Alexandra Téllez Corral, Bruno Bueno-Silva, Daniel R. Suárez, David Díaz-Báez, Lina J. Suárez
Objective: To evaluate the in vitro antimicrobial and antibiofilm properties and the immune modulatory activity of cannabidiol (CBD) and cannabigerol (CBG) on oral bacteria and periodontal ligament fibroblasts (PLF). Methods: Cytotoxicity was assessed by propidium iodide flow cytometry on fibroblasts derived from the periodontal ligament. The minimum inhibitory concentration (MIC) of CBD and CBG for
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A Comprehensive Review of Recent Research into the Effects of Antimicrobial Peptides on Biofilms—January 2020 to September 2023 Antibiotics (IF 4.8) Pub Date : 2024-04-09 Alessio Fontanot, Isabella Ellinger, Wendy W. J. Unger, John P. Hays
Microbial biofilm formation creates a persistent and resistant environment in which microorganisms can survive, contributing to antibiotic resistance and chronic inflammatory diseases. Increasingly, biofilms are caused by multi-drug resistant microorganisms, which, coupled with a diminishing supply of effective antibiotics, is driving the search for new antibiotic therapies. In this respect, antimicrobial
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Comparative Efficacy of Continuous Ceftazidime Infusion vs. Intermittent Bolus against In Vitro Ceftazidime-Susceptible and -Resistant Pseudomonas aeruginosa Biofilm Antibiotics (IF 4.8) Pub Date : 2024-04-09 Cristina El Haj, Eugènia Agustí, Eva Benavent, Laura Soldevila-Boixader, Raül Rigo-Bonnin, Fe Tubau, Benjamín Torrejón, Jaime Esteban, Oscar Murillo
Background: As the anti-biofilm pharmacokinetic/pharmacodynamic (PK/PD) properties of antibiotics are not well-defined, we have evaluated the PK/PD indices for different regimens of ceftazidime (CAZ; with/without colistin) against Pseudomonas aeruginosa biofilm. Methods: We have used the Center for Disease Control and Prevention Biofilm Reactor with two susceptible (PAO1 and HUB-PAS) and one resistant
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Differences in the Synovial Fluid Proteome of Septic and Aseptic Implant Failure Antibiotics (IF 4.8) Pub Date : 2024-04-09 Andrea Sowislok, André Busch, Farnusch Kaschani, Markus Kaiser, Marcus Jäger
Implant loosening is a severe complication after total joint replacement. Here, differential diagnosis between septic and aseptic cases is crucial for further surgical treatment, but low-grade periprosthetic joint infections (PJIs) in particular remain a challenge. In this study, we analyzed the synovial fluid proteome of 21 patients undergoing revision surgery for septic (eight cases) or aseptic (thirteen
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Anticandidal Activity of a Siderophore from Marine Endophyte Pseudomonas aeruginosa Mgrv7 Antibiotics (IF 4.8) Pub Date : 2024-04-10 Essam Kotb, Amira H. Al-Abdalall, Ibtisam Ababutain, Nada F. AlAhmady, Sahar Aldossary, Eida Alkhaldi, Azzah I. Alghamdi, Hind A. S. Alzahrani, Mashael A. Almuhawish, Moudhi N. Alshammary, Asmaa A. Ahmed
An endophytic symbiont P. aeruginosa-producing anticandidal siderophore was recovered from mangrove leaves for the first time. Production was optimal in a succinate medium supplemented with 0.4% citric acid and 15 µM iron at pH 7 and 35 °C after 60 h of fermentation. UV spectra of the acidic preparation after purification with Amberlite XAD-4 resin gave a peak at 400 nm, while the neutralized form
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Concomitant and Bismuth Quadruple Therapy for Helicobacter pylori Eradication in Southern Italy: Preliminary Data from a Randomized Clinical Trial Antibiotics (IF 4.8) Pub Date : 2024-04-10 Giuseppe Losurdo, Antonia Valeria Borraccino, Adriana Aloisio, Francesco Russo, Giuseppe Riezzo, Grazia Galeano, Maria Pricci, Bruna Girardi, Francesca Celiberto, Andrea Iannone, Enzo Ierardi, Alfredo Di Leo
Concomitant therapy (CT) and bismuth quadruple therapy (BQT) are recommended in geographical areas with high clarithromycin resistance for Helicobacter pylori (H. pylori) eradication. We compared CT and BQT as the first lines of treatment in a randomized controlled trial. Consecutive patients with H. pylori diagnosed by concordance of both a urea breath test and histology were recruited. For BQT, patients
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Comparison of IncK-blaCMY-2 Plasmids in Extended-Spectrum Cephalosporin-Resistant Escherichia coli Isolated from Poultry and Humans in Denmark, Finland, and Germany Antibiotics (IF 4.8) Pub Date : 2024-04-10 Meiyao Che, Ana Herrero Fresno, Cristina Calvo-Fernandez, Henrik Hasman, Paula E. Kurittu, Annamari Heikinheimo, Lisbeth Truelstrup Hansen
Escherichia coli carrying IncK-blaCMY-2 plasmids mediating resistance to extended-spectrum cephalosporins (ESC) has been frequently described in food-producing animals and in humans. This study aimed to characterize IncK-blaCMY-2-positive ESC-resistant E. coli isolates from poultry production systems in Denmark, Finland, and Germany, as well as from Danish human blood infections, and further compare
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Dalbavancin for Acute Bacterial Skin and Skin Structure Infections in Pediatrics: Insights from Continuation Therapy Experience Antibiotics (IF 4.8) Pub Date : 2024-04-04 Sara Maria Scarano, Eugenia Bruzzese, Marco Poeta, Margherita Del Bene, Alfredo Guarino, Andrea Lo Vecchio
Acute Bacterial Skin and Skin Structure Infections (ABSSSI) are marked by substantial morbidity, frequent need for hospitalization, and long courses of intravenous antibiotic therapy. Herein, we report four cases of pediatric patients admitted for ABSSSI and managed with a combination antibiotic regimen incorporating dalbavancin: a second-generation lipoglycopeptide active against Gram-positive bacteria
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Reintroduction of Legacy Antibiotics in Neonatal Sepsis: The Special Role of Fosfomycin and Colistin Antibiotics (IF 4.8) Pub Date : 2024-04-05 Maria Baltogianni, Niki Dermitzaki, Chrysoula Kosmeri, Anastasios Serbis, Foteini Balomenou, Vasileios Giapros
Neonatal sepsis is a leading cause of morbidity and mortality in neonates, particularly in low- and middle-income countries. The emergence of antimicrobial resistance is a rapidly growing global problem. A significant proportion of the pathogens that commonly cause neonatal sepsis are resistant to multiple antibiotics. Therefore, for the empirical treatment of neonatal sepsis, the repurposing of older
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Revisiting the Checkerboard to Inform Development of β-Lactam/β-Lactamase Inhibitor Combinations Antibiotics (IF 4.8) Pub Date : 2024-04-07 Darren J. Bentley
A two-dimensional “checkerboard” array employing systematic titration (e.g., serial two-fold dilutions) is a well-established in vitro method for exploring the antibacterial effects of novel drug combinations. Minimum inhibitory concentrations (MICs) on the checkerboard are isoeffective points at which the antibiotic potency is the same. Representations of checkerboard MIC curves for a β-lactam and
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Helicobacter pylori Secondary Antibiotic Resistance after One or More Eradication Failure: A Genotypic Stool Analysis Study Antibiotics (IF 4.8) Pub Date : 2024-04-07 Giuseppe Losurdo, Martino Mezzapesa, Ilaria Ditonno, Mariapaola Piazzolla, Maria Pricci, Bruna Girardi, Francesca Celiberto, Grazia Galeano, Giuseppe Riezzo, Francesco Russo, Andrea Iannone, Enzo Ierardi, Alfredo Di Leo
Helicobacter pylori (H. pylori) antibiotic resistance is the leading cause for unsuccessful eradication therapy. After one or more failures, the chance of encountering secondary antibiotic resistance increases. The aim of this study was to characterize genotypic secondary resistance in a cohort of southern Italian H. pylori patients with at least one previous failure. Such patients collected stool
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Emerging Issues on Antibiotic-Resistant Bacteria Colonizing Plastic Waste in Aquatic Ecosystems Antibiotics (IF 4.8) Pub Date : 2024-04-08 Ifra Ferheen, Roberto Spurio, Stefania Marcheggiani
Antibiotic-resistant bacteria (ARB) adhesion onto plastic substrates is a potential threat to environmental and human health. This current research investigates the prevalence of two relevant human pathogens, Staphylococcus spp. and Klebsiella spp., and their sophisticated equipment of antibiotic-resistant genes (ARGs), retrieved from plastic substrates submerged into an inland water body. The results
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Synthesis, Characterization, and Evaluation of the Antimicrobial Effects and Cytotoxicity of a Novel Nanocomposite Based on Polyamide 6 and Trimetaphosphate Nanoparticles Decorated with Silver Nanoparticles Antibiotics (IF 4.8) Pub Date : 2024-04-08 Leonardo Antônio de Morais, Francisco Nunes de Souza Neto, Thayse Yumi Hosida, Danilo Martins dos Santos, Bianca Carvalho de Almeida, Elisabete Frollini, Sergio Paulo Campana Filho, Debora de Barros Barbosa, Emerson Rodrigues de Camargo, Alberto Carlos Botazzo Delbem
This study aimed to develop a polymeric matrix of polyamide-6 (P6) impregnated with trimetaphosphate (TMP) nanoparticles and silver nanoparticles (AgNPs), and to evaluate its antimicrobial activity, surface free energy, TMP and Ag+ release, and cytotoxicity for use as a support in dental tissue. The data were subjected to statistical analysis (p < 0.05). P6 can be incorporated into TMP without altering
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Inhibition of Clinical MRSA Isolates by Coagulase Negative Staphylococci of Human Origin Antibiotics (IF 4.8) Pub Date : 2024-04-08 Ellen Twomey, Paula M. O’Connor, Aidan Coffey, Maija Kiste, Caitriona M. Guinane, Colin Hill, Des Field, Máire Begley
Staphylococcus aureus is frequently highlighted as a priority for novel drug research due to its pathogenicity and ability to develop antibiotic resistance. Coagulase-negative staphylococci (CoNS) are resident flora of the skin and nares. Previous studies have confirmed their ability to kill and prevent colonization by S. aureus through the production of bioactive substances. This study screened a
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Antibiotic Residues, Antimicrobial Resistance and Intervention Strategies of Foodborne Pathogens Antibiotics (IF 4.8) Pub Date : 2024-04-02 Yongning Wu, Zhenling Zeng
The primary determinant of human health is undoubtedly safe food [...]
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Candida auris Outbreak in a Multidisciplinary Hospital in Romania during the Post-Pandemic Era: Potential Solutions and Challenges in Surveillance and Epidemiological Control Antibiotics (IF 4.8) Pub Date : 2024-04-03 Violeta Melinte, Alexandra Daniela Tudor, Adrian Georgian Bujoi, Maria-Adelina Radu, Maria Cristina Văcăriou, Ioana Miriana Cismaru, Tiberiu Sebastian Holban, Carmen Luminița Mîrzan, Ruxandra Popescu, Robert Cătălin Ciupan, Alin Baciu, Oriana Elena Moraru, Matei Popa-Cherecheanu, Valeriu Gheorghiță
Candida auris is a newly emerging yeast, which is raising public health concerns due to its outbreak potential, lack of protocols for decontamination and isolation of patients or contacts, increased resistance to common antifungals, and associated high mortality. This research aimed to describe the challenges related to identifying the outbreak, limiting further contamination, and treating affected
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Meropenem–Vaborbactam for the Treatment of Post-Neurosurgical Meningitis Caused by KPC Producer Klebsiella Pneumoniae: A Case Report and Review of the Literature Antibiotics (IF 4.8) Pub Date : 2024-04-05 Leonardo Francesco Rezzonico, Francesco Peracchi, Marta Vecchi, Gabriele Bassi, Marco Merli, Nicholas Brian Bana, Giovanna Travi, Fulvio Crippa, Massimo Puoti
Meningitis and ventriculitis, due to carbapenem-resistant Enterobacterales, are frequently associated with significant morbidity and mortality. In the case of multi-drug-resistant pathogens, it is necessary to consider the limited susceptibility profile as well as the penetration of the antimicrobials into the brain. Limited data are available regarding the treatment of central nervous system infections
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Occurrence of Antimicrobial-Resistant Bacteria in Intestinal Contents of Wild Marine Fish in Chile Antibiotics (IF 4.8) Pub Date : 2024-04-05 Claudio D. Miranda, Christopher Concha, Luz Hurtado, Rocío Urtubia, Rodrigo Rojas, Jaime Romero
Antimicrobial-resistant bacteria (ARB) from the intestinal contents of wild fish may have a relevant ecological significance and could be used as indicators of antimicrobial-resistance dissemination in natural bacterial populations in water bodies impacted by urban contamination. Thus, the occurrence of ARB in the intestinal contents of pelagic and demersal wild fishes captured in anthropogenic-impacted
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Using Subcritical Water to Obtain Polyphenol-Rich Extracts with Antimicrobial Properties Antibiotics (IF 4.8) Pub Date : 2024-04-05 Tjaša Žagar, Rok Frlan, Nina Kočevar Glavač
The use of green extraction methods that meet the criteria of sustainable and environmentally friendly technologies has been increasing in recent decades due to their many benefits. In this respect, extracts obtained using subcritical water are also gaining increased attention because of their potential antioxidant and antimicrobial properties. Their antimicrobial activity is mainly due to the presence
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Development of a High-Throughput Analytical Method for Antimicrobials in Wastewater Using an Automated Pipetting and Solid-Phase Extraction System Antibiotics (IF 4.8) Pub Date : 2024-04-05 Takashi Azuma, Nobuaki Matsunaga, Norio Ohmagari, Makoto Kuroda
Antimicrobial resistance (AMR) has emerged and spread globally. Recent studies have also reported the presence of antimicrobials in a wide variety of aquatic environments. Conducting a nationwide monitoring survey of AMR in the environment to elucidate its status and to assess its impact on ecosystems and human health is of social importance. In this study, we developed a novel high-throughput analysis
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Variation in Pen-Level Prevalence of BRD Bacterial Pathogens and Antimicrobial Resistance Following Feedlot Arrival in Beef Calves Antibiotics (IF 4.8) Pub Date : 2024-04-02 Jennifer N. Abi Younes, John R. Campbell, Simon J. G. Otto, Sheryl P. Gow, Amelia R. Woolums, Murray Jelinski, Stacey Lacoste, Cheryl L. Waldner
Antimicrobials are crucial for treating bovine respiratory disease (BRD) in beef feedlots. Evidence is needed to support antimicrobial use (AMU) decisions, particularly in the early part of the feeding period when BRD risk is highest. The study objective was to describe changes in prevalence and antimicrobial susceptibility of BRD bacterial pathogens at feedlot processing (1 day on feed (1DOF)), 12
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Current Epidemiological Status and Antibiotic Resistance Profile of Serratia marcescens Antibiotics (IF 4.8) Pub Date : 2024-04-03 Ilaria Cosimato, Biagio Santella, Sandra Rufolo, Paola Sabatini, Massimiliano Galdiero, Mario Capunzo, Giovanni Boccia, Veronica Folliero, Gianluigi Franci
The spread of antibiotic resistance represents a serious worldwide public health issue, underscoring the importance of epidemiology research in determining antimicrobial strategies. The purpose of this research was to investigate antibiotic resistance in Serratia marcescens isolates from clinical samples over seven years at the University Hospital “San Giovanni di Dio e Ruggi d’Aragona” in Salerno
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Age-Related Differences in Vancomycin-Associated Nephrotoxicity and Efficacy in Methicillin-Resistant Staphylococcus aureus Infection: A Comparative Study between Elderly and Adult Patients Antibiotics (IF 4.8) Pub Date : 2024-04-03 Lin Xi, Shanshan Li, Mengting Chen, Xiaolan Huang, Nanyang Li, Nanye Chen, Hailan Wu, Qiyu Bian, Xingchen Bian, Xin Li, Minjie Yang, Xiaoyu Liang, Jufang Wu, Beining Guo, Yaxin Fan, Jing Zhang
Elderly patients (age ≥ 65 years) are susceptible to methicillin-resistant Staphylococcus aureus (MRSA) infections, with potential for more adverse treatment outcomes or complications compared to younger adults (18–64 years). This study compared vancomycin-associated nephrotoxicity and efficacy in elderly and adult patients and investigated the correlation between vancomycin pharmacokinetic/pharmacodynamic
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A Study of Metabolites from Basidiomycota and Their Activities against Pseudomonas aeruginosa Antibiotics (IF 4.8) Pub Date : 2024-04-03 Marco Clericuzio, Giorgia Novello, Mattia Bivona, Elisa Gamalero, Elisa Bona, Alice Caramaschi, Nadia Massa, Alberto Asteggiano, Claudio Medana
The World Health Organization (WHO) promotes research aimed at developing new drugs from natural compounds. Fungi are important producers of bioactive molecules, and they are often effective against other fungi and/or bacteria and are thus a potential source of new antibiotics. Basidiomycota crude extracts, which have previously been proven to be active against Pseudomonas aeruginosa ATCC27853, were
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SWOT and Root Cause Analyses of Antimicrobial Resistance to Oral Antimicrobial Treatment of Cystitis Antibiotics (IF 4.8) Pub Date : 2024-04-04 Pradeep Tyagi, Shachi Tyagi, Laurence Stewart, Scott Glickman
Nearly 150 million cases of urinary tract infections (UTIs) are reported each year, of which uncomplicated cystitis triggers > 25% of outpatient prescriptions of oral antimicrobial treatment (OAT). OAT aids immune cells infiltrating the urothelium in eliminating uropathogens capable of invading the urothelium and surviving hyperosmotic urine. This self-evident adaptability of uropathogens and the short
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Antibiotic Stewardship in Surgical Departments Antibiotics (IF 4.8) Pub Date : 2024-04-04 Irene Kourbeti, Aikaterini Kamiliou, Michael Samarkos
Antimicrobial resistance (AMR) has emerged as one of the leading public health threats of the 21st century. New evidence underscores its significance in patients’ morbidity and mortality, length of stay, as well as healthcare costs. Globally, the factors that contribute to antimicrobial resistance include social and economic determinants, healthcare governance, and environmental interactions with impact
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Synergistic Antibacterial Effects of Gallate Containing Compounds with Silver Nanoparticles in Gallate Crossed Linked PVA Hydrogel Films Antibiotics (IF 4.8) Pub Date : 2024-03-29 John Jackson, Claudia Helena Dietrich
Currently available silver-based antiseptic wound dressings have limited patient effectiveness. There exists a need for wound dressings that behave as comfortable degradable hydrogels with a strong antibiotic potential. The objectives of this project were to investigate the combined use of gallates (either epi gallo catechin gallate (EGCG), Tannic acid, or Quercetin) as both PVA crosslinking agents
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Efficacy and Synergistic Potential of Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum L. Merr. & Perry) Essential Oils to Control Food-Borne Pathogens in Fresh-Cut Fruits Antibiotics (IF 4.8) Pub Date : 2024-03-31 Ramona Iseppi, Eleonora Truzzi, Carla Sabia, Patrizia Messi
The presence of microbial pathogens in ready-to-eat produce represents a serious health problem. The antibacterial activity of cinnamon (Cinnamomum zeylanicum) and clove (Syzygium aromaticum L. Merr. & Perry) essential oils (EOs) was determined toward food-borne pathogens by agar disk diffusion and minimum inhibitory concentration (MIC) assays. The growth kinetics of all strains, both in a buffer suspension
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Epidemiology, Clinical, and Microbiological Characteristics of Multidrug-Resistant Gram-Negative Bacteremia in Qatar Antibiotics (IF 4.8) Pub Date : 2024-03-31 Hamad Abdel Hadi, Soha R. Dargham, Faiha Eltayeb, Mohamed O. K. Ali, Jinan Suliman, Shiema Abdalla M. Ahmed, Ali S. Omrani, Emad Bashir Ibrahim, Yuzhou Chen, Clement K. M. Tsui, Sini Skariah, Ali Sultan
Antimicrobial resistance is a global healthcare threat with significant clinical and economic consequences peaking at secondary and tertiary care hospitals where multidrug-resistant Gram-negative bacteria (MDR GNB) lead to poor outcomes. A prospective study was conducted between January and December 2019 for all invasive bloodstream infections (BSIs) secondary to MDR GNB in Qatar identified during
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Rebound Inverts the Staphylococcus aureus Bacteremia Prevention Effect of Antibiotic Based Decontamination Interventions in ICU Cohorts with Prolonged Length of Stay Antibiotics (IF 4.8) Pub Date : 2024-03-29 James Hurley
Could rebound explain the paradoxical lack of prevention effect against Staphylococcus aureus blood stream infections (BSIs) with antibiotic-based decontamination intervention (BDI) methods among studies of ICU patients within the literature? Two meta-regression models were applied, each versus the group mean length of stay (LOS). Firstly, the prevention effects against S. aureus BSI [and S. aureus
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Perioperative Considerations for the Surgical Treatment of Crohn’s Disease with Discussion on Surgical Antibiotics Practices and Impact on the Gut Microbiome Antibiotics (IF 4.8) Pub Date : 2024-03-30 Shelbi Olson, Lindsay Welton, Cyrus Jahansouz
Crohn’s disease, a chronic inflammatory process of the gastrointestinal tract defined by flares and periods of remission, is increasing in incidence. Despite advances in multimodal medical therapy, disease progression often necessitates multiple operations with high morbidity. The inability to treat Crohn’s disease successfully is likely in part because the etiopathogenesis is not completely understood;
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Anti-Staphylococcal Biofilm Effects of a Liposome-Based Formulation Containing Citrus Polyphenols Antibiotics (IF 4.8) Pub Date : 2024-03-30 Diletta Mazzantini, Mariacristina Massimino, Marco Calvigioni, Virginia Rossi, Francesco Celandroni, Antonella Lupetti, Giovanna Batoni, Emilia Ghelardi
Biofilms are surface-associated microbial communities embedded in a matrix that is almost impenetrable to antibiotics, thus constituting a critical health threat. Biofilm formation on the cornea or ocular devices can lead to serious and difficult-to-treat infections. Nowadays, natural molecules with antimicrobial activity and liposome-based delivery systems are proposed as anti-biofilm candidates.
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NRX-101 (D-Cycloserine + Lurasidone) Is Active against Drug-Resistant Urinary Pathogens In Vitro Antibiotics (IF 4.8) Pub Date : 2024-03-28 Michael T. Sapko, Michael Manyak, Riccardo Panicucci, Jonathan C. Javitt
D-Cycloserine (DCS) is a broad-spectrum antibiotic that is currently FDA-approved to treat tuberculosis (TB) disease and urinary tract infection (UTI). Despite numerous reports showing good clinical efficacy, DCS fell out of favor as a UTI treatment because of its propensity to cause side effects. NRX-101, a fixed-dose combination of DCS and lurasidone, has been awarded Qualified Infectious Disease
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Dosing Regimen for Cefotaxime Should Be Adapted to the Stage of Renal Dysfunction in Critically Ill Adult Patients—A Retrospective Study Antibiotics (IF 4.8) Pub Date : 2024-03-29 Théo Dillies, Sophie Perinel-Ragey, Patricia Correia, Jérôme Morel, Guillaume Thiery, Manon Launay
Cefotaxime administration is recommended in doses of 3–12 g/day in adults with a Glomerular Filtration Rate (GFR) > 5 mL/min. This study aimed to assess the impact of renal function and obesity on cefotaxime concentrations in intensive care unit (ICU) patients. A retrospective cohort study was conducted on consecutive ICU patients receiving continuous cefotaxime infusion between 2020 and 2022 [IRBN992021/CHUSTE]