-
Dissolution enhancement of Gefitinib by solid dispersion and complexation with β-cyclodextrins: In vitro testing, cytotoxic activity, and tablet formulation Saudi Pharm. J. (IF 4.1) Pub Date : 2024-04-16 Adel F. Alghaith, Gamal M. Mahrous, Ahmed S. Alenazi, Suliaman M. ALMufarrij, Mohammed S. Alhazzaa, Awwad A. Radwan, Abdullah S. Alhamed, Mohamed S. Bin Salamah, Sultan Alshehri
Cancer is the leading cause of mortality worldwide. In patients with metastatic non-small cell lung cancer, epidermal growth factor receptor (EGFR) is often overexpressed. Gefitinib (GEF), an inhibitor of EGFR, is approved for the treatment of patients with metastatic non-small cell lung cancer (NSCLC). However, the low solubility and dissolution of GEF limits its bioavailability. Numerous methods
-
Isotretinoin self-nano-emulsifying drug delivery system: Preparation, optimization and antibacterial evaluation Saudi Pharm. J. (IF 4.1) Pub Date : 2024-04-12 Rihaf Alfaraj, Sandra Hababah, Esra K. Eltayb, Fulwah Y. Alqahtani, Fadilah S. Aleanizy
Isotretinoin (ITN) is a poorly water-soluble drug. The objective of this study was to design a successful liquid self-nanoemulsifying drug delivery system (L-SNEDDS) for ITN to improve its solubility, dissolution rate, and antibacterial activity. According to solubility and emulsification studies, castor oil, Cremophor EL, and Transcutol HP were selected as system excipients. A pseudo ternary phase
-
A critical review of workplace drug testing methods for old and new psychoactive substances: Gaps, advances, and perspectives Saudi Pharm. J. (IF 4.1) Pub Date : 2024-04-08 Ahmed Ibrahim Al-Asmari
Workplace drug testing (WDT) is essential to prevent drug abuse disorders among the workforce because it can impair work performance and safety. However, WDT is limited by many challenges, such as urine adulteration, specimen selection, and new psychoactive substances (NPS). This review examined the issues related to WDT. Various scientific databases were searched for articles on WDT for drug detection
-
Sorafenib and Piperine co-loaded PLGA nanoparticles: Development, characterization, and anti-cancer activity against hepatocellular carcinoma cell line Saudi Pharm. J. (IF 4.1) Pub Date : 2024-04-07 Sulaiman S. Alhudaithi, Mohd Abul Kalam, Lama Binobaid, Raisuddin Ali, Mohammed M. Almutairi, Wajhul Qamar, Hessa Bin Hithlayn, Atheer Almutairi, Abdullah K. Alshememry
Hepatocellular carcinoma (HCC) exhibits high mortality rates in the advanced stage (>90 %). Sorafenib (SORA) is a targeted therapy approved for the treatment of advanced HCC; however, the reported response rate to such a therapeutic is suboptimal (<3%). Piperine (PIP) is an alkaloid demonstrated to exert a direct tumoricidal activity in HCC and improve the pharmacokinetic profiles of anticancer drugs
-
Corrigendum to “A narrative review of approved and emerging anti-obesity medications” [Saudi Pharm. J. 31(10) (2023) 101757] Saudi Pharm. J. (IF 4.1) Pub Date : 2024-04-05 Semira Abdi Beshir, Asim Ahmed Elnour, Aadith Soorya, Affana Parveen Mohamed, Sheron Sir Loon Goh, Nadia Hussain, Amal H.I. Al Haddad, Faizah Hussain, Israa Yousif EL Khidir, Zainab Abdelnassir
-
Unveiling potent Schiff base derivatives with selective xanthine oxidase inhibition: In silico and in vitro approach Saudi Pharm. J. (IF 4.1) Pub Date : 2024-04-04 Fatna Bellahcene, Khedidja Benarous, Arif Mermer, Houssem Boulebd, Talia Serseg, Abderahmane Linani, Alaeddine Kaouka, Mohamed Yousfi, Asad Syed, Abdallah M. Elgorban, Yasuhiro Ozeki, Sarkar M.A. Kawsar
-
Ketamine-based Sedation Use in Mechanically Ventilated Critically Ill Patients with COVID-19: A Multicenter Cohort Study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-04-03 Ohoud Aljuhani, Khalid Al Sulaiman, Ghazwa B. Korayem, Ali F. Altebainawi, Abdulrahman Alshaya, Majed Nahari, Khuzama Alsamnan, Munirah A. Alkathiri, Bodoor S. Al-Dosari, Abeer A. Alenazi, Samiah Alsohimi, Lina I. Alnajjar, Mashael Alfaifi, Nora AlQussair, Reem M. Alanazi, Munirah F. Alhmoud, Nadin L. Alanazi, Hadeel Alkofide, Aljawharah M. Alenezi, Ramesh Vishwakarma
Ketamine possesses analgesia, anti-inflammation, anticonvulsant, and neuroprotection properties. However, the evidence that supports its use in mechanically ventilated critically ill patients with COVID-19 is insufficient. The study's goal was to assess ketamine's effectiveness and safety in critically ill, mechanically ventilated (MV) patients with COVID-19. Adult critically ill patients with COVID-19
-
Population pharmacokinetics of gentamicin in acute lymphoblastic leukemia pediatric patients compared to non-oncology patients Saudi Pharm. J. (IF 4.1) Pub Date : 2024-04-01 Hisham S. Abou-Auda, Fatimah Alotaibi, Sary Alsanea, Abdulrahman Alwhaibi, Mohammed M. Almutairi, Ziyad Alrabiah, Abdullah Alsultan, Majed Al Jeraisy
Understanding the pharmacokinetics of gentamicin is essential in special populations, such as pediatric patients with acute lymphoblastic leukemia (ALL), in light of previous studies indicating that ALL patients have a lower volume of distribution than non-ALL patients. Furthermore, validation of such results is needed to ensure their clinical application. Accordingly, this single-center, retrospective
-
Pioglitazone enhances cisplatin’s impact on triple-negative breast cancer: Role of PPARγ in cell apoptosis Saudi Pharm. J. (IF 4.1) Pub Date : 2024-04-01 Qamraa Hamad Alqahtani, Layla Abdullah Alkharashi, Hanaa Alajami, Ishraq Alkharashi, Layan Alkharashi, Shoug Nasser Alhinti
Peroxisome proliferator-activated receptor-gamma (PPARγ) has been recently shown to play a role in many cancers. The breast tissue of triple-negative breast cancer (TNBC) patients were found to have a significantly lower expression of PPARγ than the other subtypes. Furthermore, PPARγ activation was found to exert anti-tumor effects by inhibiting cell proliferation, differentiation, cell growth, cell
-
Fabrication and evaluation of ribavirin-loaded electrospun nanofibers as an antimicrobial wound dressing Saudi Pharm. J. (IF 4.1) Pub Date : 2024-04-01 Khulud A. Alsulami, Abrar A. Bakr, Abdullah A. Alshehri, Alhassan H. Aodah, Fahad A. Almughem, Ali A. Alamer, Lujain A. Alharbi, Deema S. Alsuwayeh, Abdulrahman A. Halwani, Abdullah A. Alamoudi, Haya A. Alfassam, Essam A. Tawfik
-
Cost consequence analysis of adding semaglutide to treatment regimen for patients with Type II diabetes in Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-29 Yazed AlRuthia, Khaled Hani Aburisheh, Sondus Ata, Raghad Bin Salleeh, Shahad B. Alqudhibi, Raghad B. Alqudhibi, Ziad Alkraidis, Hala Humood Alkhalaf, Abdulrahman Abdullah Almogirah, Muhammad Mujammami, Reem Al Khalifah
Semaglutide, a Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA), is often prescribed for managing type 2 diabetes, particularly in cases unresponsive to other hypoglycemic agents. Despite its popularity, the real-world efficacy and cost-effectiveness of Semaglutide relative to other treatments remain understudied. This study aimed to examine the direct medical cost and consequences of adding Semaglutide
-
Arabic translation and cultural adaptation of Hill-Bone compliance to high blood pressure therapy scale Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-29 Ibrahim Sales, Yazed AlRuthia
Adherence to prescription medications is vital to the success of any treatment plan, especially for chronic health conditions, such as hypertension (HTN). Although there are different scales used in assessing adherence to prescription medications, most if not all, of those scales are not available in Arabic. The absence of essential assessment tools makes the appraisal of adherence to prescription
-
The use and perceived value of electronic health information resources by health care professionals in the field of medicine, pharmacy, and nursing in Jazan province, Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-28 Saad S. Alqahtani, Santhosh Joseph Menachery, Renju Ravi, Tahir Hakami, Manal Almalki
Healthcare workers increasingly use Electronic Health Information Resources (EHIRs) to make evidence-based decisions. Our study was intended to assess the perception, attitude, and practice of healthcare professionals in medicine, pharmacy, and nursing regarding their perceived value and use of EHIRs. We conducted an observational cross-sectional study using a pre-validated questionnaire among healthcare
-
The prevalence of cardiovascular diseases, chronic kidney disease, and obesity in patients with type 2 diabetes mellitus and the description of concurrent treatments: A two-center retrospective cross-sectional study in Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-28 Omar A. Alshaya, Ghazwa B. Korayem, Munirah Alghwainm, Wed Alyami, Albandari Alotaibi, Majed S. Alyami, Omar A. Almohammed
Atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), chronic kidney disease (CKD), and obesity are associated with increased morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Nonetheless, their prevalence among patients with T2DM in Saudi Arabia (SA) remains unknown. As current guidelines recommend, these comorbidities require adding certain antidiabetic agents
-
Iron-tannic acid nano-coating: A promising treatment approach for enhancing Lactococcus lactis antibiotic resistance Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-27 Marwa M. Elmaghrabi, Naiyf S. Alharbi, Ahmed S. Alobaidi, Adel A. Abdulmanea, Shine Kadaikunnan, Asmaa A. Ramadan, Jamal M. Khaled
The objective of this study was to explore a novel methodology for the synthesis of nanocoated probiotics following their collection and cultivation under optimized conditions, in light of their significant contribution to human health. Probiotics are instrumental in sustaining immune health by modulating the gastrointestinal microbiota and facilitating digestion. However, the equilibrium they maintain
-
A nanocomposite competent to overcome solubility and permeation issues of capsaicin and thiocolchicoside simultaneously in gout management: Fabrication of nanocubosomes Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-24 Barkat Ali Khan, Falak Naz, Ali Alqahtani, Muhammad Khalid Khan
This study aimed to formulate nano-cubosomes (NCs) co-loaded with capsaicin (CAP) and thiocolchicoside (TCS) to enhance their bioavailability and minimize associated potential side effects through transdermal delivery alongside their synergistic activity. Twenty seven (27) nano-cubosomal dispersions were prepared according to Box-Behnken factorial design and the effect of CAP, TCS, glyceryl mono oleate
-
The effect mechanism of ergosterol from the nutritional mushroom Leucocalocybe mongolica in breast cancer cells: Protein expression modulation and metabolomic profiling using UHPLC-ESI-Q Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-23 Asmaa Hussein Zaki, Bao Haiying, Mohamed Mohany, Salim S. Al-Rejaie, Bahaa Abugammie
The ergosterol from mushrooms has gained significant ethnopharmacological importance in various cultures, including China, Japan, and Europe. This compound has been found to possess immune-boosting and anti-inflammatory properties, making it useful in the treatment of immune disorders. In this study, we focused on investigating the potential anticancer properties of ergosterol isolated from the edible
-
The effectiveness of hematopoietic stem cell transplantation in treating pediatric sickle cell disease: Systematic review and meta-analysis Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-22 Najim Z. Alshahrani, Mohammed R. Algethami
-
Formulation and characterization of polymeric nanoparticle of Rivastigmine for effective management of Alzheimer’s disease Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-22 Faisal Imam, Sayantan Mukhopadhyay, Preeti Kothiyal, Samiyah Alshehri, Khalid Saad Alharbi, Muhammad Afzal, Muzaffar Iqbal, Mohammad Rashid Khan, Md. Khalid Anwer, Abdulrazaq Ahmed Hattab Alanazi, Ali Ghanem Alqahtani, Mohammed Abdullah Alhamamah
Memory loss or dementia is a progressive disorder, and one of its common forms is Alzheimer’s disease (AD), effecting mostly middle aged and older adults. In the present study, we developed Rivastigmine (RIV) nanoparticles using poly(lactic-co-glycolic acid) (RIV-loaded PLGA NPs) and polyvinyl alcohol (PVA). The prepared RIV-PLGA nanoparticles was evaluated for the management of Alzheimer's disease
-
Amphiphilic, lauric acid-coupled pluronic-based nano-micellar system for efficient glipizide delivery Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-21 Vipan Kumar, Neelam Poonia, Pradeep Kumar, Prabhakar Kumar Verma, Abdulrahman Alshammari, Norah A. Albekairi, Atul Kabra, Neera Yadav
Glipizide; an insulin secretagogue belonging to the sulfonylurea class, is a widely used antidiabetic drug for managing type 2 diabetes. However, the need for life-long administration and repeated doses poses challenges in maintaining optimal blood glucose levels. In this regard, orally active sustained-release nano-formulations can be a better alternative to traditional antidiabetic formulations.
-
Factors associated with applicant performance on the Saudi Pharmacist Licensure Examination (SPLE) Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-20 Wael A. Alghamdi, Tahani M. Almeleebia, Mona A. Almanasef, Khalid M. Orayj
Limited data are available on factors that are associated with passing rates for the Saudi Pharmacist Licensure Examination (SPLE). The aim of this study is to investigate student characteristics and academic performance characteristics that may predict their success on SPLE. This was a single-institution retrospective cohort study, which included pharmacy graduates from 2019 to 2021. Demographic,
-
Strengths and weaknesses of current and future prospects of artificial intelligence-mounted technologies applied in the development of pharmaceutical products and services Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-19 Ahmed M. Abdelhaleem Ali, Majed M. Alrobaian
Starting from drug discovery, through research and development, to clinical trials and FDA approval, artificial intelligence (AI) plays a vital role in planning, developing, assessing modelling, and optimization of product attributes. In recent decades, machine-learning algorithms integrated into artificial neural networks, neuro-fuzzy logic and decision trees have been applied to tremendous domains
-
Healthcare Providers’ knowledge, attitudes and practice in relation to drug hypersensitivity reactions at King Abdulaziz Medical City in Riyadh Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-19 Mohammed Alrashed, Ahmed A. Alanazi, Khalid Bin Saleh, Faisal Alanazi, Ahmed S. Alanazi, Sumayyah Mashraqi, Madhawi Mahdali, Abdullah Alshammari, Mohammed A Alnuhait, Mohammed Alzahrani, Tariq Alqahtani
Drug hypersensitivity reactions (DHRs) are immune-mediated responses triggered by exposure to a drug. DHRs are responsible for serious adverse drug reactions (ADRs) and are considered the fifth leading cause of death. This study aims to assess and evaluate the knowledge, practice, and attitudes of healthcare providers (HCPs) towards DHRs. A cross-sectional survey was conducted at King Abdulaziz Medical
-
Assessing the antibacterial potential of 6-gingerol: Combined experimental and computational approaches Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-18 Mahmoud A. Elfaky, Hassan M. Okairy, Hossam M. Abdallah, Abdulrahman E. Koshak, Gamal A. Mohamed, Sabrin R.M. Ibrahim, Abdulrahim A. Alzain, Wael A.H. Hegazy, El-Sayed Khafagy, Noura M. Seleem
The rise of antibiotic resistance in bacteria is becoming a global concern, particularly due to the dwindling supply of new antibiotics. This situation mandates the discovery of new antimicrobial candidates. Plant-derived natural compounds have historically played a crucial role in the development of antibiotics, serving as a rich source of substances possessing antimicrobial properties. Numerous studies
-
Safety of prolonged use of metoclopramide and domperidone as treatment for chronic gastrointestinal dysmotility disorders in patients with systemic sclerosis Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-16 Saad Alkhowaiter, Maha M. Al Rasheed, Nuha Alammar, Ammar Alotaibi, Mansour Altuwaijri, Suliman Alshankiti, Mohammed A. Omair, Majid Alsahafi
Metoclopramide and domperidone are prokinetic agents commonly used to treat gastrointestinal dysmotility disorders. This study aimed to evaluate the safety and associated side effects of prolonged-use metoclopramide and domperidone as treatment for chronic gastrointestinal dysmotility disorders in patients with systemic sclerosis (SSc). A quantitative observational survey was conducted by interview
-
Development and evaluation of sildenafil/glycyrrhizin-loaded nanofibers as a potential novel buccal delivery system for erectile dysfunction Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-15 Ali A. Alamer, Abdullah A. Alshehri, Alhassan H. Aodah, Fahad A. Almughem, Hamzah A. Alghmadi, Amer S. Alali, Abdulrahman A. Halwani, Mohammed Muqtader Ahmed, Essam A. Tawfik
Erectile dysfunction (ED) is a growing health condition that needs safe and effective therapy. One of the main common treatments is sildenafil which is used in clinics for managing erectile dysfunction by enhancing the blood supply to the penis. In the current study, sildenafil was formulated as nanofibers and mixed with the root extract of (glycyrrhizin) as a natural sweetener to be administrated
-
The amelioration effect of antidiabetic agents on cytokine expression in patients with type 2 diabetes mellitus Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-13 Abeer M. Abd El-Hameed, Areej A. Eskandrani, Eman Salah Abdel-Reheim, Adel Abdel Moneim, Wessam Addaleel
Inflammation is a condition that is closely linked to diabetes mellitus type 2 (T2DM), short for T2DM several different antidiabetic medications have been produced to regulate hyperglycemia, with indications that these therapies may have anti-inflammatory effects along with their glucose-lowering efficacy. Thus, this research was planned to explore the impact of antidiabetic agents on the cytokine
-
Virtual reality in experiential pharmacy education: A quasi-experimental study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-13 Nora Alkhudair, Fatma Alrayes, Dalal Alsehli, Shahad AlRayes
Extended reality (XR) technologies are an umbrella term for simulated-based learning tools that cover 3-dimensional technologies, including virtual reality (VR), augmented reality (AR), and mixed reality (MR). At King Saud University, first-year pharmacy students are required to experience hospital observational training during the Introductory Pharmacy Practice Experience (IPPE). We aimed to measure
-
Community pharmacist intervention in doxycycline self-medication for acne among pregnant women in Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-13 Marwan Alrasheed, Wael Hamdy Mansy, Mohamed Naser Al-Arifi
Self-medication during pregnancy remains a prevalent global phenomenon, with pregnant women often relying on their own judgment to manage symptoms. This study aimed to assess community pharmacist practice regarding self-medication requests for acne treatment in pregnant women within Saudi Arabia. A descriptive, observational cross-sectional study was conducted in Riyadh, Saudi Arabia. Community pharmacists
-
Exploring the therapeutic mechanism of potential phytocompounds from Kalanchoe pinnata in the treatment of diabetes mellitus by integrating network pharmacology, molecular docking and simulation approach Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-13 Rekha Y. Halayal, Zabin K. Bagewadi, Nayef Abdulaziz Aldabaan, Ibrahim Ahmed Shaikh, Aejaz Abdullatif Khan
-
Synthesis, in silico ADMET prediction analysis, and pharmacological evaluation of sulfonamide derivatives tethered with pyrazole or pyridine as anti-diabetic and anti-Alzheimer's agents Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-12 Nagwa M. Abdelazeem, Wael M. Aboulthana, Ashraf S. Hassan, Abdulrahman A. Almehizia, Ahmed M. Naglah, Hamad M. Alkahtani
Based on previous developments of our research programs in trying to find new compounds with multiple biological targets such as antioxidant, anti-diabetic, anti-Alzheimer's, and anti-arthritic agents. In the context, a novel series of sulfonamide derivatives based on the pyrazole or pyridine moieties –– and were synthesized from amine compounds with sulfonyl chloride derivatives. The structures of
-
Estimating implicit and explicit racial and ethnic bias among community pharmacists in Canada Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-11 Fahad Alzahrani, Nancy Waite, Michael Beazely, Martin Cooke
Bias, whether implicit (unconscious) or explicit (conscious), can lead to preferential treatment of specific social groups and antipathy towards others. When healthcare professionals (HCPs), including pharmacists, act on these biases, patient care and health outcomes can be adversely affected. This study aims to estimate implicit and explicit racial/ethnic bias towards Black and Arab people among community
-
Investigation of phytochemicals isolated from selected Saudi medicinal plants as natural inhibitors of SARS CoV-2 main protease: In vitro, molecular docking and simulation analysis Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-08 Yousef T.M. Alharbi, Wael M. Abdel-Mageed, Omer A. Basudan, Ramzi A. Mothana, Md Tabish Rehman, Ali A. ElGamal, Ali S. Alqahtani, Omer I. Fantoukh, Mohamed F. AlAjmi
-
Evaluation of the effectiveness of natural extract as a substituent for synthetic preservatives and antioxidants in pharmaceutical preparations Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-07 Fuad Al-Rimawi, Mahmood Sbeih, Mousa Amayreh, Belal Rahhal, Samer Mudalal
Despite the fact that synthetic preservatives and antioxidants have strong antibacterial and antioxidant activity, they are frequently associated with negative health consequences. Currently, there is an increasing interest in pharmaceutical products that are excellent in quality and free of synthetic preservatives. As a result, the purpose of this research is to assess the antibacterial and antioxidant
-
Clinical pharmacists’ knowledge, attitude, perception, and beliefs about the role of pharmacogenetic testing for genes polymorphisms when prescribing mercaptopurine Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-06 Norah O. Abanmy, Sara A. Alghamdi, Raneem K. Aljudaie, Omar A. Almohammed
Single nucleotide polymorphisms in the gene encoding proteins involved in mercaptopurine metabolism can influence drug efficacy and safety. This study aims to assess clinical pharmacists’ knowledge about mercaptopurine-related genes and their polymorphisms and investigate their attitudes, perceptions, and beliefs about the need for and importance of pharmacogenetic testing for mercaptopurine. A cross-sectional
-
Do pharmacists counsel customers on the disposal of unused or expired household medications? A national survey among 1,596 pharmacists in Indonesia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-05 Sofa D. Alfian, Farida Rendrayani, Qisty A. Khoiry, Mochammad A.A. Pratama, Meliana Griselda, Ivan Surya Pradipta, Nursiswati Nursiswati, Rizky Abdulah
Pharmacists play a vital role in counseling customers on proper medication disposal, yet their consistency in providing such information is often lacking. This study aimed to assess pharmacists’ awareness of appropriate disposal practices for unused and expired household medications. Additional objectives included evaluating whether pharmacists offer disposal information during counseling, measuring
-
Awareness and knowledge of sun exposure and use of sunscreen among adults in Aseer region, Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-05 Emad Bahashwan
Excessive sun exposure and inadequate sunscreen use can lead to skin cancer and other harmful effects on the skin, eyes, and immune system. This observational cross-sectional study aimed to assess awareness and knowledge of sun exposure and sunscreen use among adults in the Aseer region, Saudi Arabia. This study also focused on evaluating the risks of skin cancer and participants’ sun-protective attitudes
-
Methanol intoxication in the central region of Saudi Arabia: Five case studies Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-05 Sattam A. Alnefaie, Abdulaziz A. Aldlgan, Khalid M. Albakiri, Mohammed A. Kaabi, Ghada M. Alzwen, Sarah S. Al-Otaibi, Fawaz Alasmari
Outbreaks of methanol poisoning have been described in the medical literature worldwide. However, the few outbreaks that have occurred in Saudi Arabia remain undocumented. This is especially noteworthy in light of the fact that Saudi Arabia is among the countries that explicitly prohibit the usage of alcoholic beverages and recreational drugs. Herein, we describe five cases of methanol poisoning in
-
An exploration of factors influencing the selection of generic and innovator medicines in Saudi Arabia using an observational cross-sectional study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-05 Othman AlOmeir, Mansour Almuqbil, Asmaa Hussam Alsawadi, Alaa Mohamed Genedy, Ashwag fawaz Almutairi, Hams Talal Alaydaa, Saleh A. Alanazi, Numan Alabdan, Meshal Alshakrah, Rafiulla Gilkaramenthi, Syed Mohammed Basheeruddin Asdaq, Naira Nayeem
Generic medications are cost-effective without compromising therapeutic outcomes. Therefore, the goal of this study was to investigate, using a cross-sectional study design, the factors influencing Saudi Arabian consumers' preferences between innovator and generic medications. This cross-sectional study was carried out in Saudi Arabia using a Google survey form. For data collection, a simple random
-
Use of potentially inappropriate medication for elderly patients in tertiary care hospital of Riyadh, Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-03-01 Saleh A. Alanazi, Abdulrahman Al Amri, Mansour Almuqbil, Abdullah Alroumi, Merna Gamal Mohamed Alahmadi, Joud Obaid Ayesh Alotaibi, May Mohammed Sulaiman Alenazi, Wejdan Hassan Mossad Alahmadi, Alzahraa Hassan Saleh Al Bannay, Shorooq Khaled Ahmad Marai, Safier M. AlKhatham, Sarah Al-kanhal, Syed Mohammed Basheeruddin Asdaq
The elderly population is affected by chronic diseases and lifelong medication. The American Geriatrics Society (AGS) Beers Criteria is a comprehensive approach to medication usage in the older population to reduce potentially inappropriate medication (PIM) use. The purpose of this study was to assess the usage of PIMs in elderly patients upon discharge from tertiary care hospital settings in Riyadh
-
Exploring the therapeutic potential of Derris elliptica (Wall.) Benth in Streptozotocin-Induced diabetic Rats: Phytochemical characterization and antidiabetic evaluation Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-28 Rassheda Abd Rahman, Hanish Singh Jayasingh Chellammal, Syed Adnan Ali Shah, Rozaini Mohd Zohdi, Dhani Ramachandran, Hannis Fadzillah Mohsin
-
A detailed review of pharmacology of MFN1 (mitofusion-1)-mediated mitochondrial dynamics: Implications for cellular health and diseases Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-28 Adel Alghamdi
The mitochondria are responsible for the production of cellular ATP, the regulation of cytosolic calcium levels, and the organization of numerous apoptotic proteins through the release of cofactors necessary for the activation of caspases. This level of functional adaptability can only be attained by sophisticated structural alignment. The morphology of the mitochondria does not remain unchanged throughout
-
The effect of mephedrone on human neuroblastoma and astrocytoma cells Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-28 Ibrahim M. Alanazi, Abdullah R. Alzahrani, Mohammad A. Alsaad, Abdulaziz L. Moqeem, Abdulmohsen M. Hamdi, Mohiuddin M. Taher, David G. Watson, M. Helen Grant
Mephedrone is an illegal drug that is used recreationally. Few studies have been conducted to investigate the mechanisms by which mephedrone is harming cells. In this research, we investigated the effect of mephedrone using toxicology coupled with LC-MS/MS based metabolomics in the two CNS derived cell lines. Methods of assessment such as neutral red (NR) assay, dimethylthiazolyl diphenyltetrazolium
-
Team-based learning versus traditional teaching effect on pharmacy Students’ Performance: A systematic review and Meta-Analysis Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-27 Ghazwa B. Korayem, Albandari A. Alghamdi, Ohoud Aljuhani, Delaney Ivy, Alaa A. Alhubaishi, Hadeel Alkofide
Several pharmacy schools have implemented team-based learning (TBL) in their curriculum worldwide. Yet, TBL's effectiveness compared to traditional teaching in improving students’ outcomes in pharmacy education is yet to be assessed collectively. Thus, the aim of this meta-analysis is to compare the performance of pharmacy students following the implementation of team-based learning (TBL) in the pharmacy
-
Pectin hydrogels for controlled drug release: Recent developments and future prospects Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-24 Devesh U. Kapoor, Rahul Garg, Mansi Gaur, Ashutosh Pareek, Bhupendra G. Prajapati, Guillermo R. Castro, Supakij Suttiruengwong, Pornsak Sriamornsak
-
Development of nanoemulgel of 5-Fluorouracil for skin melanoma using glycyrrhizin as a penetration enhancer Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-24 Nimish Gupta, G.D. Gupta, Karan Razdan, Norah A. Albekairi, Abdulrahman Alshammari, Dilpreet Singh
The purpose of this study was to enhance the topical delivery of 5-Fluorouracil (5-FU), a cancer treatment, by developing a nanoemulgel formulation. Glycyrrhizin (GLY), a natural penetration enhancer has been investigated to exhibit synergistic effects with 5-FU in inhibiting melanoma cell proliferation and inducing apoptosis, Hence, GLY, along with suitable lipids was utilized to create an optimized
-
Prevalence and antimicrobial susceptibility pattern of methicillin-resistant Staphylococcus aureus (MRSA) at a maternity and children hospital in Saudi Arabia: A cross-sectional study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-24 Hadiah Almutairi, Heyam Albahadel, Abdullah A. Alhifany, Hind Aldalbahi, Faris S. Alnezary, Ibrahim Alqusi, Mugahid A. Mobark, Masaad Saeed Almutairi
Methicillin-resistant (MRSA) pathogens are considered a serious global health threat, leading to increased mortality and antimicrobial resistance. Rates in Saudi Arabia remain high, necessitating continuous surveillance. This study investigates MRSA prevalence and susceptibility at a Saudi maternity and children's hospital. A cross-sectional study was conducted on pediatric (<18 years) and maternal
-
-
-
Current situation and barriers to women’s leadership in health care education in Saudi Arabia: A cross-sectional study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-21 Ohoud S. Almalki, Ahmed Ibrahim Fathelrahman, Osamah M. Alfayez, Ghada A. Bawazeer
The aims of the current study were to explore the true representation of female academic staff who have advanced to leadership positions in Saudi health academic institutions and to determine the possible barriers to women’s advancement to leadership positions in academia. This was a cross-sectional study conducted between August 2022 and August 2023 using an adapted self-reported online questionnaire
-
Physicochemical and biological properties of encapsulated Boesenbergia rotunda extract with different wall materials in enhancing antioxidant, mineralogenic and osteogenic activities of MC3T3-E1 cells Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-20 Safiah Saah, Dalad Siriwan, Piyapat Trisonthi, Sawitree Dueramae
-
A content-quality and optimization analysis of YouTube as a source of patient information for bipolar disorder Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-20 Jawza F. Alsabhan, Haya M. Almalag, Norah O. Abanmy, Yara I. Aljadeed, Reema H. Alhassan, Awatif B. Albaker
The goal of this study was to identify and evaluate the use of Arabic YouTube videos on BD as a resource for patient education. A cross-sectional evaluation of YouTube videos as a source of information for patients with BD in Arabic was performed. The study was observational and, because it did not involve human subjects, it followed the STROBE guidelines whenever possible. The quality of the videos
-
An analysis of the intention of female pharmacy students to work in community pharmacy settings in Saudi Arabia using the theory of planned behavior Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-18 Ahmed M. Alshehri, Wafa H. Alqahtani, Aljoharah A. Moaili, Yasser S. Almogbel, Ziyad S. Almalki, Abdullah K. Alahmari, Ahmed A. Albassam, Nehad J. Ahmed
This study aimed to determine the intention of female Saudi pharmacy students to work in community pharmacies and the factors associated with this intention. This cross-sectional study was conducted between April 2022 and June 2022 and included female students from pharmacy colleges in Saudi Arabia. The survey was created based on the Theory of Planned Behavior. It included items that measure student
-
Exploring the effectiveness of pharmacy curriculum in Saudi Arabia in developing leadership skills among pharmacy students from their perspective: A mixed-methods study Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-18 Majid Ali, Aseel Alsreaya, Abdulrahman Alqarzi, Yazeed Alzahrani, Ibrahim Alhomood, Abdulaziz Alruhaimi, Abdulrahman Hijri, Ahmed Mobarki, Mohammed Najie, Mohammed Mashyakhi, Abdullwahab Bajawi
Leadership is an important component of pharmacy education. This study helps identify the strengths and limitations of the pharmacy curriculum in developing leadership skills among pharmacy students in Saudi Arabia and suggest how to improve the curriculum to better prepare them to become effective leaders in the healthcare profession. This study employed a mixed-methods research design with a sequential
-
Improvement of comorbid anxiety and depression in patients with migraine treated with injectable preventive calcitonin gene-related peptide antagonists: Review of clinical evidence Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-15 Abubker Omaer, Abdulrazaq Albilali, Reem Bamogaddam, Fares Almutairi, Raghad Alsaif, Osama Almohammadi, Abdullah A Alhifany
Migraine is often associated with depression and anxiety, leading to a diminished quality of life. Calcitonin gene‐related peptide (CGRP) antagonists have shown promise in treating migraines, but their effects on concurrent depression and anxiety have not been clarified. A literature review was conducted on ClinicalTrials.gov, PubMed, Ovid Medline, and EMBASE focusing on phase 3 clinical trials, post-hoc
-
New flavonoids with multiple bronchodilator activity pathways from Tephrosia purpurea L. (Pers.) growing in Saudi Arabia Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-15 Maged S. Abdel-Kader, Abdulaziz S. Saeedan, Najeeb U. Rehman, Hayder M. Faqihi, Gamal A. Soliman
Total extract of () expressed potent bronchodilator effect in isolated Guinea pigs’ tracheal muscles. Fractionation of total extract ( using liquid–liquid technique followed by bronchodilator testing indicated that the activity was trapped to the chloroform (CHCl) soluble fraction. Phytochemical study of the CHCl fraction guided by bronchodilator activity led to the isolation of 7 active flavones of
-
NMDA receptor modulation by Esculetin: Investigating behavioral, biochemical and neurochemical effects in schizophrenic mice model Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-15 Iqra Khalid, Uzma Saleem, Bashir Ahmad, Mohammed F. Hawwal, Ramzi A. Mothana
Schizophrenia, a global mental health disorder affecting approximately 1 % of the population, is characterized by neurotransmitter dysregulation, particularly dopamine, serotonin, and glutamate. Current antipsychotic therapies, despite their efficacy, are accompanied by adverse effects, which has motivated researchers to investigate more secure substitutes. This study examines the potential antipsychotic
-
Exploring the topic structure and abuse trends of new psychoactive Substance since the 21st century from a bibliometric perspective Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-15 Xiaolong Hou, Jifen Wang, Ying Zhang, Yufan Zhang, Jianyang Shangguan, Ge Qin, Boxu Chen, Zhenjun Jia, Duo qi Xu
Nowadays, NPS abuse are continuing to expand in terms of harm and scope, due to its cheap and easy to manufacture anywhere in the world. This study reviewed articles related to seven heavily abused NPS to analyze the structure and trends of NPS abuse. A total of 2476 articles were retrieved based on the search strategy for bibliometric analysis. A significant trend of research in recent years was the
-
Muslim pilgrims’ knowledge, attitudes, and practices regarding complementary and alternative medicine (CAM); a study conducted during Hajj season Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-12 Aljawharah A. Alqathama, Rizwan Ahmad
Complementary and alternative medicine (CAM) has attracted much interest, and its prevalence in both developed and developing countries has increased. During the Hajj season, millions of Muslims from many different countries travel to Makkah for the pilgrimage. In dealing with health issues during the holy season, many pilgrims prefer to self-medicate with traditional remedies instead of visiting medical
-
Chemical profile and biological properties of the Piper corcovadense C.DC. essential oil Saudi Pharm. J. (IF 4.1) Pub Date : 2024-02-12 Bruno Henrique Fontoura, Ellen Cristina Perin, Ana Paula Buratto, Jucemar Francisco Schreiner, Kamyla Menezes Cavalcante, Sirlei Dias Teixeira, Daiane Manica, Rafael Antônio Narzetti, Gilnei Bruno da Silva, Margarete Dulce Bagatini, Tatiane Luiza Cadorin Oldoni, Solange Teresinha Carpes
The essential oil fromPiper corcovadense D.DC. (EOPc), an important plant belonging to the Piperaceae family, which is commonly found in the northern region of Brazil and poorly explored scientifically, was used in this study. Thus, the EOPc was characterized chemically by Gas Chromatography/Mass Spectrometry (GC/MS) and the antioxidant and antimicrobial activities and their potential effects on cutaneous