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Carbon-based Nanomaterials in Photothermal Therapy Guided by Photoacoustic Imaging: State of Knowledge and Recent Advances Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-26 Yan Xing, Rui Jing, Jun Kang, Yuwen Li, Hui Zhang, Xiaoying Tang, Zhenqi Jiang
: Carbon-based nanomaterials (CBNM)have been widely used in various fields due to their excellent physicochemical properties. In particular, in the area of tumor diagnosis and treatment, researchers have frequently reported them for their potential fluorescence, photoacoustic (PA), and ultrasound imaging performance, as well as their photothermal, photodynamic, sonodynamic, and other therapeutic properties
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Role of ABCA1 in Atherosclerosis: Novel Mutations and Potential Plant-derived Therapies Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-26 Siarhei A. Dabravolski, Nikolay A. Orekhov, Victor Y. Glanz, Vasily N. Sukhorukov, Elizaveta M. Pleshko, Alexander N. Orekhov
abstract: ATP-binding cassette transporter A1 (ABCA1) is one of the key proteins regulating cholesterol homeostasis and playing a crucial role in atherosclerosis development. ABCA1 regulates the rate-limiting step of reverse cholesterol transport, facilitates the efflux of surplus intracellular cholesterol and phospholipids, and suppresses inflammation through several signalling pathways. At the same
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Fragment-based Drug Discovery Strategy and its Application to the Design of SARS-CoV-2 Main Protease Inhibitor Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-26 Yu Jiang, Yingnan Wu, Jing Wang, Yuheng Ma, Hui Yu, Zhanli Wang
: Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) emerged at the end of 2019, causing a highly infectious and pathogenic disease known as 2019 coronavirus disease. This disease poses a serious threat to human health and public safety. The SARS-CoV-2 main protease (Mpro) is a highly sought-after target for developing drugs against COVID-19 due to its exceptional specificity. Its crystal
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A Novel Gene Signature Based on Immune Cell Infiltration Landscape Predicts Prognosis in Lung Adenocarcinoma Patients Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-26 Chao Ma
Background: The tumor microenvironment (TME) is created by the tumor and dominated by tumor-induced interactions. Long-term survival of lung adenocarcinoma (LUAD) patients is strongly influenced by immune cell infiltration in TME. The current article intends to construct a gene signature from LUAD ICI for predicting patient outcomes. Methods: For the initial phase of the study, the TCGA-LUAD dataset
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Composite or Modified Hydroxyapatite Microspheres as Drug Delivery Carrier for Bone and Tooth Tissue Engineering Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-25 Zhe Wang, Jiaxin Shang, Zheng Zhang
: Since hydroxyapatite (HAp) is an important constituent of bone and teeth, it has excellent biocompatibility and bioactivity, good osteoconductive effects and the ability to induce bone formation as a material for bone or tooth repair and replacement. At present, widely used HAp microspheres have some characteristics, such as large specific surface area, light mass, good injection properties, good
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Natural Herbal Compounds Exerting an Antidepressant Effect through Hypothalamic-Pituitary-Adrenal Axis Regulation Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-25 Nailong Wang, Binrui Yu, Jiayin Liu, Wei Lan
: Depression is a common mental illness that damages the life and health of patients and causes economic burden, and HPA (hypothalamic-pituitary-adrenal) axis dysfunction is considered to be one of the important factors leading to depression. In this case, it is essential to explore possible treatment methods by using natural compounds with HPA axis regulating and antidepressant effects. However, no
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Herbal Treatments for Obesity: A Review Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-21 Amin Gasmi, Sadaf Noor, Pavan Kumar Mujawdiya, Muhammad Akram, Aisha Manzoor, Geir Bjørklund
: Obesity is the most pervasive metabolic disorder, further linked with many other diseases, including diabetes, hypertension, cardiovascular disorders, and sleep apnea. To control the increasing weight of obese individuals, experts usually recommend exercise and lifestyle alterations, but medication and surgeries are also advised in severe cases. FDA-approved obesity-controlling drugs are effective
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A Review on the use of Synthetic and Recombinant Antigens for the Immunodiagnosis of Tegumentary Leishmaniasis Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-21 Kamila Silva, Anna Julia Ribeiro, Isadora Gandra, Carlos Rezende, Lucas Lopes, Carolina Couto, Verônica Freire, Isabelle Barcelos, Sabrina Pereira, Sandra Xavier, Mariana Campos-da-Paz, Rodolfo Giunchetti, Miguel Chávez-Fumagalli, Ana Alice Gonçalves, Eduardo Coelho, Alexsandro Galdino
: Improving the diagnostic technology used to detect tegumentary leishmaniasis (TL) is essential in view of it being a widespread, often neglected tropical disease with cases reported from the southern United States to northern Argentina. Recombinant proteins, recombinant multiepitope proteins, and synthetic peptides have been extensively researched and used in disease diagnosis. One of the benefits
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Significance of Aneuploidy in Predicting Prognosis and Treatment Response of Uveal Melanoma Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-20 Xiaoqian Zhang, Ling Jin, Chenchen Zhou, Jinghua Liu, Qin Jiang
Aims: This study aimed to improve personalized treatment strategies and predict survival outcomes for patients with uveal melanoma (UM). Background: Copy number aberrations (CNAs) have been considered as a main feature of metastatic UM. Objective: This study was designed to explore the feasibility of using copy number variation (CNV) in UM classification, prognosis stratification and treatment response
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Involvement of Lipids and Lipid Mediators in Inflammation and Atherogenesis Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-20 Stanislav Kotlyarov
: Atherosclerosis is the pathophysiological basis for major diseases, such as coronary heart disease, cerebral stroke, and peripheral arterial disease, which have become epidemic in modern Western society. Atherosclerosis has a complex nature that involves mutually related immune and metabolic mechanisms. Many cells of the vascular wall and peripheral bloodstream, including endothelial cells, monocytes
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Artificial Intelligence Application for Anti-tumor Drug Synergy Prediction Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-16 Zheng Peng, Yanling Ding, Pengfei Zhang, Xiaolan Lv, Zepeng Li, Xiaoling Zhou, Shigao Huang
: Currently, the main therapeutic methods for cancer include surgery, radiation therapy, and chemotherapy. However, chemotherapy still plays an important role in tumor therapy. Due to the variety of pathogenic factors, the development process of tumors is complex and regulated by many factors, and the treatment of a single drug is easy to cause the human body to produce a drug-resistant phenotype to
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EACVP: An ESM-2 LM Framework Combined CNN and CBAM Attention to Predict Anti-coronavirus Peptides Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-16 Shengli Zhang, Yuanyuan Jing, Yunyun Liang
Background:: The novel coronavirus pneumonia (COVID-19) outbreak in late 2019 killed millions worldwide. Coronaviruses cause diseases such as severe acute respiratory syndrome (SARS-Cov) and SARS-COV-2. Many peptides in the host defense system have antiviral activity. How to establish a set of efficient models to identify anti-coronavirus peptides is a meaningful study. Methods:: Given this, a new
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Synthesis of Bis-thiazoles Tethered 1,4-Dihydropyridine and Pyridine Linkers via Simple Oxidation and their Molecular Docking as VEGFR -TK Inhibitors Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-16 Jehan Y. Al-Humaidi, Sayed M. Riyadh, Basant Farag, Magdi E. A. Zaki, Tariq Z. Abolibda, Sobhi M. Gomha
Aim: In this study, a neoteric and expedient oxidation method is applied for a variety of Hantzsch 1,4-dihydropyridine derivatives such as 1,4-dihydro- 2,6-dimethyl-3,5-diacetylpyridine, 3,5-bis-hydrazono--2,6-dimethyl-1,4-dihydropyridine, and 3,5-bis-thiazoly-2,6-dimethyl-1,4-dihydro pyridines. Method: This simple oxidation is based upon the in situ generation of nitrous acid from an aqueous sodium
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Therapeutic Potential of Traditional Oriental Medicines in Targeting Tau Pathology: Insights from Cell-free and Cell-based Screening Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-16 Hyun Ha Park, Byeong-Hyeon Kim, Seol Hwa Leem, Yong Ho Park, Hyunju Chung, Doo-Han Yoo, Insu Park, Yunkwon Nam, Sujin Kim, Soo Jung Shin, Minho Moon
Background: Traditional Oriental Medicines (TOMs) formulated using a variety of medicinal plants have a low risk of side effects. In previous studies, five TOMs, namely Dangguijakyaksan, Hwanglyeonhaedoktang, Ukgansan, Palmijihwanghwan, and Jowiseungchungtang have been commonly used to treat patients with Alzheimer’s disease. However, only a few studies have investigated the effects of these five TOMs
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We Must Abandon the Myth: Oxidized Low-density Lipoprotein is not a Lipoprotein that Plays a Key Role in Atherogenesis Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-16 Alexander N. Orekhov
: The purpose of this review is to revisit in detail the arguments supporting or disproving the hypothesis that oxidized low-density lipoprotein (LDL) plays a key role in atherosclerotic lesion development. The detection of oxidized LDL in vivo was extremely important for confirming its key role in atherogenesis. Indirect evidence of its existence included the presence of autoantibodies against ma
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Identification and Verification of Metabolism-related Immunotherapy Features and Prognosis in Lung Adenocarcinoma Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-16 Junfang Luo, Jinlu An, Rongyan Jia, Cong Liu, Yang Zhang
Background: Lung cancer is a frequent malignancy with a poor prognosis. Extensive metabolic alterations are involved in carcinogenesis and could, therefore, serve as a reliable prognostic phenotype. Aims: Our study aimed to develop a prognosis signature and explore the relationship between metabolic characteristic-related signature and immune infiltration in lung adenocarcinoma (LUAD) Objective: TCGA-LUAD
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Discovery of Multiple Effects of Reactive Oxygen Species on Lung Adenocarcinoma at the Single-cell and Bulk Tissue Levels Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-15 Cong Zhang, Bin Liu, Xianjin Xie, Degan Lu
Background:: Reactive oxygen species (ROS) are potential targets for treating malignant tumors. Aims:: The aim of this study was to probe into the mechanisms of disease development and treatment in lung adenocarcinoma (LUAD). Objective:: This study investigated the impact of ROS on the progression of LUAD at different transcriptomic levels and analyzed key molecules involved in the regulation of LUAD
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3D Bioprinting and Microfluidic-Based Devices for Cancer Detection and Drug Treatment: Focus on Prostate Cancer Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-12 Jay Sibbits, Lucia Di Pietro, Anna Privitera, Vincenzo Cardaci, Salvatore Maugeri, Massimo Camarda, Giuseppe Caruso
: The burden of increasing cancer incidence among the population, and, in particular, of prostate cancer in men living in highly developed countries, brings with it, on one hand, the need for new devices that allow a faster and earlier diagnosis, ideally in a non-invasive way and with low consumption of expensive reagents, and on the other the need for the assessment of new in vitro models that allow
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Regulating Triplet Excitons of Organic Luminophores for Promoted Bioimaging Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-12 Zhipeng Zhao, Rui Du, Xiaodi Feng, Zhengshuo Wang, Tianjie Wang, Zongzhao Xie, Hua Yuan, Yeqiang Tan, Hanlin Ou
: Afterglow materials with organic room temperature phosphorescence (RTP) or thermally activated delayed fluorescence (TADF) exhibit significant potential in biological imaging due to their long lifetime. By utilizing time-resolved technology, interference from biological tissue fluorescence can be mitigated, enabling high signal-- to-background ratio imaging. Despite the continued emergence of individual
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SGPocket: A New Graph Convolutional Neural Network for Ligand-protein Binding Site Prediction Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-12 Kevin Crampon, Cedric Bourrasset, Stephanie Baud, Luiz Angelo Steffenel
Background: Drug research is a long process, taking more than 10 years and requiring considerable financial resources. Therefore, researchers and industrials aim to reduce time and cost. Thus, they use computational simulations like molecular docking to explore huge databases of compounds and extract the most promising ones for further tests. Structure-based molecular docking is a complex process mixing
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Immunotherapy of Human Melanoma: Past, Present, Future Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-08 Keywan Mortezaee, Jamal Majidpoor
: Immunotherapy with immune checkpoint inhibitors (ICIs) is a promising therapeutic schedule in advanced solid cancers. In this review, clinical trials from highly reputable journals are interpreted for safety and efficacy evaluation of the common anti-programmed death-1 (PD-1) inhibitor nivolumab and/or the most known anti-cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) inhibitor ipilimumab in
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Unlocking the Immunomodulatory Potential of Rosmarinic Acid Isolated from Punica granatum L. Using Bioactivity-Guided Approach: In Silico, In Vitro, and In Vivo Approaches Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-06 Rupesh K. Gautam, Shailesh Mani Tripathi, Shopnil Akash, Sanjay Sharma, Komal Sharma, Swapnil Goyal, Sahar Behzad, Rohit Gundamaraju, Dinesh Kumar Mishra, Yingbo Zhang, Bairong Shen, Sandeep Sundriyal, Rajeev K. Singla
Background: Punica granatum L. is well-known for its multifaceted therapeutic potential, including anti-inflammatory and immunomodulatory activities. Aim: This study aimed to characterize an immunomodulatory compound isolated from Punica granatum L. using a bioactivity-guided approach. Methods: Chromatographic techniques were adopted for isolation and purification of secondary metabolites. In silico
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Defective Mitophagy Impairs Response to Inflammatory Activation of Macrophage-Like Cells Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-05 Alexander N Orekhov, Alexander D Zhuravlev, Andrey Y Vinokurov, Nikita G Nikiforov, Andrey V Omelchenko, Vasily N Sukhorukov, Vasily V Sinyov, Igor A Sobenin
Background and Aims: The role of mitophagy in atherosclerosis has been extensively studied during the last few years. It was shown that mitophagy is involved in the regulation of macrophages, which are important players as immune cells in atherosclerosis development. In this study, we investigated the relationship between mitophagy and response to inflammatory stimulation of macrophage-like cells.
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WSCD2 Expression: Its Relevance to Tumor-Infiltrating Immune Cells and Glioma Prognosis Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-01 Kaderya Abudusalam, Yan Xu, Pazilat Keyumu, Tong Cheng, Manyu Xu, Bing Lu, Pingping Sun, Kadierjiang Musha, Jianfei Huang
Background: Patients with glioma have limited treatment options and experience poor prognoses. Therefore, it is urgently needed to explore new diagnostic and therapeutic targets. Objective: This study aimed to investigate the relevance of WSC domain-containing 2 (WSCD2) expression to glioma, clinicopathological characteristics, tumor-infiltrating immune cells (TILs), and patient prognosis. Methods:
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Ranunculin, Protoanemonin, and Anemonin: Pharmacological and Chemical Perspectives Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-01 Betelhem Sirak, Misgana Aragaw, Solomon Tadesse
: Ranunculin, a glucoside, serves as a chemotaxonomic marker in Ranunculaceae plants. When these plants are damaged, an enzyme β−glucosidase triggers the conversion of ranunculin into protoanemonin through hydrolysis. Subsequently, protoanemonin undergoes cyclodimerization to form anemonin. The inherent instability of ranunculin and the rapid dimerization of protoanemonin render them unsuitable for
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Analysis and Validation of Tyrosine Metabolism-related Prognostic Features for Liver Hepatocellular Carcinoma Therapy Curr. Med. Chem. (IF 4.1) Pub Date : 2024-03-01 Zhongfeng Cui, Chunli Liu, Hongzhi Li, Juan Wang, Guangming Li
Aims: To explore tyrosine metabolism-related characteristics in liver hepatocellular carcinoma (LIHC) and to establish a risk signature for the prognostic prediction of LIHC. Novel prognostic signatures contribute to the mining of novel biomarkers, which are essential for the construction of a precision medicine system for LIHC and the improvement of survival. Background: Tyrosine metabolism plays
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Metformin Effects on SHIP2, AMPKs and Gut Microbiota: Recent Updates on Pharmacology Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-27 Priyanka Shivaprakash, Narasimha M. Beeraka, Subba Rao V. Madhunapantula, Vladimir N. Nikolenko, Kanthesh M. Basalingappa
Introduction: Metformin, a biguanide on the WHO’s list of essential medicines has a long history of 50 years or more in treating hyperglycemia, and its therapeutic saga continues beyond diabetes treatment. Glucoregulatory actions are central to the physiological effects of metformin; surprisingly, the precise mechanism with which metformin regulates glucose metabolism is not thoroughly understood yet
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NAD Pathways in Diabetic Coronary Heart Disease: Unveiling the Key Players Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-27 Yuan Liu, Wenjing Zhan, Lexun Wang, Weixuan Wang
: Diabetic coronary heart disease is a global medical problem that poses a serious threat to human health, and its pathogenesis is complex and interconnected. Nicotinamide adenine dinucleotide (NAD) is an important small molecule used in the body that serves as a coenzyme in redox reactions and as a substrate for non-redox processes. NAD levels are highly controlled by various pathways, and increasing
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Drug-target Affinity Prediction by Molecule Secondary Structure Representation Network Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-27 Yuewei Tang, Yunhai Li, Pengpai Li, Zhi-Ping Liu
Introduction: Identification of drug-target interactions (DTI) is a crucial step in drug development with high specificity and low toxicity. To accelerate the process, computer-aided DTI prediction algorithms have been used to screen compounds or targets rapidly. Furthermore, DTI prediction can be used to identify potential targets for existing drugs, thus uncovering new indications and repositioning
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Hub Genes Involved in the Progression of Nonalcoholic Fatty Liver Disease to Hepatocellular Carcinoma Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-27 Baiyi Liu, Xiaoxiao Wang, Nan Wu, Feng Liu, Huiying Rao
Background: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. With an increasing number of patients, NAFLD has been identified as a risk factor for Hepatocellular Carcinoma (HCC). The precise pathophysiology of NAFLD-related HCC has not been completely understood recently. Objective: We analyzed the hub genes related to NAFLD and HCC to predict the
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Advanced Targeted Drug Delivery of Bioactive Agents Fortified with Graft Chitosan in Management of Cancer: A Review Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-22 Rukaiah Begum, Sudarshan Singh, Bhupendra Prajapati, M Sumithra, Ravish J. Patel
: Cancer is characterized by the uncontrolled proliferation and spread of abnormal cells in the body, resulting in the development of tumors or clusters of irregular cells. The factors contributing to cancer are intricate, involving a combination of genetic, environmental, and lifestyle elements. Risk factors for cancer include the use of nicotine, excessive alcohol consumption, exposure to radiation
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Rituximab Combined with Steroid and Tacrolimus Treats Proliferative Glomerulonephritis with Monoclonal IgG Deposits: A Case Report and Review of the Literature Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-22 Di Liu, Ming Xia, Chang Wang, Xuejing Zhu, Guochun Chen, Hong Liu
Introduction:: Due to the confounding heterogeneity, the therapeutic strategy for proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) remains to be defined. Case Representation:: We report a 38-year-old man with recurrent swelling of the eyelids and lower limbs, undergoing rituximab combined with steroid and tacrolimus treatment, who achieved an improved renal outcome. Underlying
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Discussion on the Influence of Gpx 4 Target in the Field of Cancer Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-22 Ya-Lan Wang, Hong-yan Guo, Tong Zhou, Ke Sun, Qing-kun Shen, Xiao-Ting Li
: The current review was undertaken to collate data on Gpx4 inhibitors and the regulatory proteins related to Gpx4. Gpx4 plays an essential role in ferroptosis; it can be used to determine the Gpx4 as an indicator for determining tumor occurrence and as a means of treating cancer. Although there is no market for Gpx4 inhibitors, many researchers have conducted extensive research, and some compounds
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Clinical Outcomes and Effectiveness of CRLX101 for Solid Tumors: A Systematic Review and Meta-analysis Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-22 Nahal Shamaeizadeh, Erfan Sadeghi, Jaleh Varshosaz
Background:: While it has been demonstrated that delivery of cytotoxic chemotherapy using nanoparticles greatly improves patient drug tolerance and reduces toxicity when compared to the standard formulation, the crucial question of whether they also increase anticancer efficacy remains. The CRLX101 is a nanoparticle composed of cyclodextrin and 20(S)-camptothecin cytotoxic chemotherapy Objective::
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Evidence for the Involvement of Gene Regulation of Inflammatory Molecules in the Accumulation of Intracellular Cholesterol: The Mechanism of Foam Cell Formation in Atherosclerosis Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-22 Vasily N. Sukhorukov, Victoria A. Khotina, Daria D. Borodko, Mariam Bagheri Ekta, Yumiko Oishi, Andrey V. Omelchenko, Kira I. Kolmychkova, Nikita G. Nikiforov, Igor A. Sobenin, Alexander N. Orekhov
Background: The relationship between the cellular pro-inflammatory response and intracellular lipid accumulation in atherosclerosis is not sufficiently studied. Transcriptomic analysis is one way to establish such a relationship. Previously, we identified 10 potential key genes (IL-15, CXCL8, PERK, IL-7, IL-7R, DUSP1, TIGIT, F2RL1, TSPYL2, and ANXA1) involved in cholesterol accumulation in macrophages
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Iron-related Biomarkers in the Diagnosis and Management of Iron Disorders Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-22 Yuliya Semenova, Geir Bjørklund, Monica Butnariu, Massimiliano Peana
Background: Iron deficiency and iron-related disorders are common health issues worldwide, affecting a significant proportion of the population. Diagnosis and management of these disorders rely heavily on using various iron-related biomarkers that can provide valuable clinical information. Objective: This review article provides an overview of the most commonly used iron-related biomarkers, including
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Natural Phenolic Compounds with Antithrombotic and Antiplatelet Effects: A Drug-likeness Approach Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-20 Diégina Araújo Fernandes, Ayala Nara Pereira Gomes, Camila Macaubas da Silva, Isabelly Soares de Medeiros Henriques, Renata Priscila Barros de Menezes, Marcus Tullius Scotti, Yanna Carolina Ferreira Teles, RuAngelie Edrada-Ebel, Maria de Fatima Vanderlei de Souza
Background:: Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessel diseases. Several studies have been conducted to identify antithrombotic agents from medicinal plants, and phenolic compounds (PCs) have been shown to effectively inhibit plasma coagulation and platelet aggregation. Objectives:: This study aimed to conduct a survey of the natural PCs with proven
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Mycobacterial Targets for Thiourea Derivatives: Opportunities for Virtual Screening in Tuberculosis Drug Discovery Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-20 Vinicius de Melo Milani, Mariana Luiza Silva, Priscila Goes Camargo, Marcelle de Lima Ferreira Bispo
: Tuberculosis (TB) remains a primary global health concern, necessitating the discovery and development of new anti-TB drugs, mainly to combat drug-resistant strains. In this context, thiourea derivatives have emerged as promising candidates in TB drug discovery due to their diverse chemical structures and pharmacological properties. This review aimed to explore this potential, identifying and exploring
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The Role and Therapeutic Potential of Non-coding RNAs in Resistance to EGFR-TKIs targeted therapy for Non-small Cell Lung Cancer Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-20 Yang Zhang, Ye Chen, Li-Li Lu, Xiu-Li Xie, Ren Huan, Li-Fang Wu, Li-Na Tan, Tao Xu, Yong Jin
: Lung cancer is the leading cause of cancer-related deaths worldwide, of which non-small cell lung cancer (NSCLC) is the most common type, and epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are widely used for the treatment of NSCLC. EGFR-TKIs are known to develop a drug-resistant response after a certain number of cycles of dosing, and how to alleviate or even reverse EGFR-TKI
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Novel Perspectives of TSLP and RXR Signaling in Corticosteroid-Resistant Asthma: Updates on TSLP Blockers Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-20 Song Zhang, Karen Dsouza, Narasimha M Beeraka, Junqi Liu, Oksana Reshetniak, Hemanth Vikram PR, LG Priyanka, M.V. Greeshma, Pradeep Kumar Bhupalam, Mahesh PA, Prasath Manogaran, Rajashree Deka, Gurupadayya Bannimath, Mikhail Y Sinelnikov, Vladimir N. Nikolenko, Kirill Bulygin, Ruitai Fan
: Previous studies described that asthma patients who received corticosteroid therapy have been constrained by the corticosteroid resistance subsequently fostered to severe refractory asthma. In this review, we discussed the implications of TSLP, RXR, the role of STAT5-activating cytokines, and IL-33/NH-cell signaling pathways, and recent clinical evidence on TSLP blockers in steroid-resistant asthma
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Advanced Targeted Drug Delivery of Bioactive Nanomaterials in the Management of Cancer Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-20 Biswajit Basu, Kevin Kumar Garala, Rajeshri Patel, Ayon Dutta, Dipanjana Ash, Bhupendra Prajapati, Sudarshan Singh, Sajal Kumar Jha
Cancer is defined as the unchecked expansion of aberrant cells. Radiation, chemotherapy, and surgery are currently used in combination to treat cancer. Traditional drug delivery techniques kill healthy proliferating cells when used over prolonged periods of time in cancer chemotherapy. Due to the fact that the majority of tumor cells do not infiltrate right away, this is particularly true when treating
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Cell-Penetrating Peptides as Keys to Endosomal Escape and Intracellular Trafficking in Nanomedicine Delivery Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Sakshi Soni, Shivam K. Kori, Priyanshu Nema, Arun K. Iyer, Vandana Soni, Sushil K. Kashaw
: This review article discusses the challenges of delivering cargoes to the cytoplasm, for example, proteins, peptides, and nucleic acids, and the mechanisms involved in endosomal escape. Endocytosis, endosomal maturation, and exocytosis pose significant barriers to effective cytoplasmic delivery. The article explores various endosomal escape mechanisms, such as the proton sponge effect, osmotic lysis
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Construction of a New Ferroptosis-related Prognosis Model for Survival Prediction in Colorectal Cancer Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Lin Chen, Mengxiao Ge, Shaocong Mo, Menglin Shi, Jun Zhang, Jie Liu
Aim: This study was designed to develop a ferroptosis-related gene signature for guiding the prognostic prediction in colorectal cancer (CRC) and to explore the potential in the molecular functions of the gene signature. Background: Ferroptosis is mainly characterized by lipid peroxide accumulation on the cell membranes in an iron-dependent manner, resulting in cellular oxidative stress, metabolic
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Identification and Characterization of PrognosticMacrophage Subpopulations for HumanEsophagealCarcinoma Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Penghui Li, Xiaohui Gao, Di Huang, Xinyu Gu
Aims: The aim of the present study was to investigate the relationship between the cellular ecosystem and the progression of esophageal carcinoma (ESCA) based on the evolution of macrophages and to analyze the potential of using macrophages as a new therapeutic approach in ESCA treatment. Background: Macrophage-based immunotherapy could be used for treating ESCA patients, but its clinical application
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A Comprehensive Review of Therapeutic Compounds from Plants for Neurodegenerative Diseases Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Dhaya Shankaran P., Abinaya K, Meenakumari S., Subash C.B. Gopinath, Pachaiappan Raman
: Neurodegenerative diseases (NDDs) comprise a large number of disorders that affect the structure and functions of the nervous system. The major cause of various neurodegenerative diseases includes protein aggregation, oxidative stress and inflammation. Over the last decade, there has been a gradual inclination of neurological research in order to find drugs that can prevent, slow down, or treat these
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Identifying Hub Genes for Glaucoma Based on Bulk RNA Sequencing Data and Multi-machine Learning Models Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Yangyang Xie, Kai Yu
Aims: The aims of this study were to determine hub genes in glaucoma through multiple machine learning algorithms. Background: Glaucoma has afflicted many patients for many years, with excessive pressure in the eye continuously damaging the nervous system and leading to severe blindness. An effective molecular diagnostic method is currently lacking. objective: The present study attempted to reveal
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Natural Products in Liver Fibrosis Management: A Five-year Review Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Tao Wang, Zhuo Lu, Gui-Feng Sun, Kai-Yi He, Zhi-Ping Chen, Xin-Hui Qu, Xiao-Jian Han
: Liver fibrosis, characterized by the overproduction of extracellular matrix proteins within liver tissue, poses a rising global health concern. However, no approved antifibrotic drugs are currently available, highlighting the critical need for understanding the molecular mechanisms of liver fibrosis. This knowledge could not only aid in developing therapies but also enable early intervention, enhance
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The Use of Isoflavones as Lung Cancer Chemoprevention Agents and their Implications in Treatment through Radio Sensitization Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Efstratios Athanasiou, Savvas Papageorgiou, Marianna Foteini Dafni, Ioannis Kelesis, Maria Vasileiou, Theodora Tatsiou, Vasiliki Kouveloglou, Panagiotis Kanatas, Ioannis Stouras, Athanasios Gatsis, Vasiliki Taxiarchoula Agiassoti, Petros Nasimpian, Dimitrios Dafnoudis, Kyriaki Degaita, Georgios Ioannis Verras, Athanasios Alexiou, Marios Papadakis, Mohammad Amjad Kamal
: Epidemiological trends in cancer research show that lung cancer can affect up to 1 in 15 men and 1 in 17 women. With incidence rates as high as these and significant associated mortality and morbidity, it is no wonder that lung cancer is one of the main areas of research focused on cancer. Advances in targeted treatments and specialized irradiation protocols have allowed the treatment of more advanced
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Evolution and Trends of Aptamers in Cancer Research: A Bibliometric Analysis of the Literature over the Last Decade Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Song Jiang, Mao-Sheng Liu, Ting Wang, Kun-He Zhang
Objective: Aptamers are increasingly applied in cancer research. Here, we have performed the first bibliometric analysis to demonstrate the evolution of aptamers in cancer research over the past decade and to reveal future trends. background: none Method: Original articles and reviews on aptamers in cancer research published from 2013 to 2022 were retrieved from the Web of Science Core Collection database
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Nanocrystal Structure of Minoxidil: A Safe Stimulator for Hair Growth Factor for C57BL/6 Mice Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Ali Moradi, Seyed Morteza Seifati, Majid Darroudi, Shiva Golmohammadzadeh, Mahmood Dehghani Ashkezari
Background:: Commercial Minoxidil (MXD) is commonly used as a vasodilator agent of hair follicles for providing direct dermal papilla cell proliferation and consequently enhancing the rate of hair growth. Objective:: The current study attempted to improve the bioactivity and water solubility of MXD by producing nanocrystal structures and investigating the obtained hair growthstimulating activity on
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Does Gut Microbiome have an Effect on Wilson’s Disease Phenotype? Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Shan Gao, Mei Zhou, Hedong Zhang, Zhenchu Tang
: Wilson’s Disease (WD), a genetic metabolic disorder, is characterized by the accumulation of copper in the liver and brain, resulting in a range of clinical symptoms. The clinical manifestations of WD vary widely. The present study introduces the distinctive features of intestinal microbiota in Chinese patients with WD, presenting diverse clinical symptoms. It shows a reduction in the diversity of
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Progress of Influenza Viruses and Inhibitors Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-16 Yuchen Xiao, Jianping Yong, Shaoji Lu, Canzhong Lu, Ruiwen Huang
: Influenza is an acute respiratory disease caused by influenza viruses. It has the characteristics of fast transmission and strong infectivity, and it does great harm to human health and survival. It is estimated that the seasonal influenza epidemics every year will cause about one billion cases of infections and hundreds of thousands of deaths worldwide, while influenza A virus is the leading cause
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Hesperetin Inhibits Bladder Cancer Cell Proliferation and Promotes Apoptosis and Cycle Arrest by PI3K/AKT/FoxO3a and ER Stress-mitochondria Pathways Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-15 Yao Su, Lin Chen, Jin Yang
Background and Objectives: Hesperetin (HSE) is a natural flavonoid derived from the hydrolysis of Hesperidin, which is mainly found in traditional natural Chinese herbs, such as Chenpi and Hovenia caryophyllus. HSE displays anti-inflammatory and antioxidant activities. However, its potential mechanism of action on bladder cancer (BLCA) remains unknown. The aim of this study was to investigate the potential
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Prediction Model for Therapeutic Responses in Ovarian Cancer Patients Using Paclitaxel-Resistant Immune-Related lncRNAs Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-15 Xin Li, Huiqiang Liu, Fanchen Wang, Jia Yuan, Wencai Guan, Guoxiong Xu
Background:: Ovarian cancer (OC) is the deadliest malignant tumor in women with a poor prognosis due to drug resistance and lack of prediction tools for therapeutic responses to anti- cancer drugs. Objective:: The objective of this study was to launch a prediction model for therapeutic responses in OC patients. Methods:: The RNA-seq technique was used to identify differentially expressed paclitaxel
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Discovery of Pyroptosis-inducing Drugs and Antineoplastic Activity Based on the ROS/ER Stress/Pyroptosis Axis Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-15 Xin Gan, Jingwen Xie, Zhaojun Dong, Yuna Wu, Xiaoqing Zeng, Zhenzhen Yang, Bo Liu, Min Zhu, Bozhen Wang, Wulan Li, Ledan Wang, Huajie Zhang, Jianzhang Wu, Yue Hu
Background: Pyroptosis, a cell death process triggered by chemotherapy drugs, has emerged as a highly promising mechanism for combating tumors in recent years. As the lead of new drugs, natural products play an important role in the discovery of anticancer drugs. Compared to other natural products, the medicine food homologous natural products (MFHNP) exhibit a superior safety profile. Among a series
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Structural-based Study to Identify the Repurposed Candidates Against Bacterial Infections Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-15 Debanjan Dey, Anoop Kumar
Background::: Microbial infections are mostly caused by Gram-positive as well as Gram-negative bacteria affecting millions of people worldwide. There is an urgent need to explore existing molecules or discover new chemical entities (NCEs) against bacterial infection. Objective:: The main objective of the current investigation is to explore recently US-FDA- approved drugs (2019-2023) against various
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Multi-omics Combined with Machine Learning Facilitating the Diagnosis of Gastric Cancer Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-14 Jie Li, Siyi Xu, Feng Zhu, Fei Shen, Tianyi Zhang, Xin Wan, Saisai Gong, Geyu Liang, Yonglin Zhou
: Gastric cancer (GC) is a highly intricate gastrointestinal malignancy. Early detection of gastric cancer forms the cornerstone of precision medicine. Several studies have been conducted to investigate early biomarkers of gastric cancer using genomics, transcriptomics, proteomics, and metabolomics, respectively. However, endogenous substances associated with various omics are concurrently altered
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Modulation of the HIF-1α-NCOA4-FTH1 Signaling Axis Regulating Ferroptosis-induced Hepatic Stellate Cell Senescence to Explore the Anti-hepatic Fibrosis Mechanism of Curcumol Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-13 Yang Zheng, Lei Wang, Jiaru Wang, Tiejian Zhao, Jiahui Wang
Introduction: Senescence of activated hepatic stellate cells (HSC) reduces extracellular matrix expression to reverse liver fibrosis. Ferroptosis is closely related to cellular senescence, but its regulatory mechanisms need to be further investigated. The iron ions weakly bound to ferritin in the cell are called labile iron pool (LIP), and together with ferritin, they maintain cellular iron homeostasis
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Research Progress on the Antioxidant Activity of Natural Diarylheptanoids: Mechanisms and Structure–activity Relationships Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-13 An-Na Ma, Tie Yao, Ya-Jing Guo, Chong-Yan Zhao, Bing-jie Wang, Gen Li, Feng Qiu
: Antioxidant research has recently become a popular topic. Medicinal plants are important sources of novel active compounds. Diarylheptanoids, a typical family of secondary plant metabolites, are of great interest owing to their extensive spectrum of biological activities. They possess a unique 1,7-diphenylmethane structural skeleton. Thus, this review summarizes the natural linear or macrocyclic
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Binding of Nucleotide Inhibitors to the NS5 RdRp of the ZIKA Virus in the Replication Initiation State Curr. Med. Chem. (IF 4.1) Pub Date : 2024-02-13 S. Pant, N. R. Jena
INTRODUCTION: The bindings of several ribonucleoside triphosphate (NTP) inhibitors to the RNA-dependent RNA polymerase (RdRp) of the Zika virus (ZIKV) are studied herein to identify potential drug-like candidates that can inhibit the replication of the viral genome by RdRp. METHOD: In this study, a guanosine triphosphate (GTP) bound RdRp structure is generated to model the replication initiation state