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Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway Amino Acids (IF 3.5) Pub Date : 2024-04-18 Yachen Wang, Bihu Gao, Xiaochi Chen, Xiaoxia Shi, Shuangyue Li, Qing Zhang, Cong Zhang, Fengyuan Piao
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Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage Amino Acids (IF 3.5) Pub Date : 2024-04-14 Chunlei Yang, Zhiwen Jiang, Xinjie Gao, Heng Yang, Jiabin Su, Ruiyuan Weng, Wei Ni, Yuxiang Gu
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Effects of cancer-induced cachexia and administration of l-glutathione on the intestinal mucosa in rat Amino Acids (IF 3.5) Pub Date : 2024-04-12 Sabrina Silva Sestak, Fabiana Galvão da Motta Lima, Ana Paula de Oliveira, Letícia Ganem Rillo Paz Barateiro, Flávia Cristina Vieira-Frez, Sara Raquel Garcia de Souza, Flávia Alessandra Guarnier, Juliana Vanessa Colombo Martins Perles, Jacqueline Nelisis Zanoni
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Pharmacokinetics of L-theanine and the effect on amino acid composition in mice administered with L-theanine Amino Acids (IF 3.5) Pub Date : 2024-04-07 Shinnosuke Yamaura, Koki Sadamori, Reiko Konishi, Takashi Majima, Akira Mukai, Kyosuke Uno, Toshihiko Kinjo, Koji Komori, Nobuyuki Kuramoto, Kou Kawada
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Antibacterial activity of a short de novo designed peptide against fish bacterial pathogens Amino Acids (IF 3.5) Pub Date : 2024-04-05 Raja Aadil Hussain Bhat, Victoria C. Khangembam, Vinita Pant, Ritesh Shantilal Tandel, Pramod Kumar Pandey, Dimpal Thakuria
In the face of increasing antimicrobial resistance in aquaculture, researchers are exploring novel substitutes to customary antibiotics. One potential solution is the use of antimicrobial peptides (AMPs). We aimed to design and evaluate a novel, short, and compositionally simple AMP with potent activity against various bacterial pathogens in aquaculture. The resulting peptide, KK12YW, has an amphipathic
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Superior bioavailability of the calcium salt form of β-hydroxy-β-methylbutyrate compared with the free acid form Amino Acids (IF 3.5) Pub Date : 2024-04-02
Abstract We investigated the bioavailability of the calcium salt (HMB-Ca) and the free acid (HMB-FA) forms of β-hydroxy-β-methylbutyrate (HMB). Sixteen young individuals received the following treatments on three different occasions in a counterbalanced crossover fashion: (1) HMB-FA in clear capsules; (2) HMB-Ca in gelatine capsules; (3) HMB-Ca dissolved in water. All treatments provided 1 g of HMB
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Reductive amination of ω-conotoxin MVIIA: synthesis, determination of modification sites, and self-assembly Amino Acids (IF 3.5) Pub Date : 2024-03-30 Xiufang Ding, Yue Wang, Sida Zhang, Ruihua Zhang, Dong Chen, Changcai Liu, Jianfu Xu, Long Chen
Peptide drugs have disadvantages such as low stability, short half-life and side effects, which limit their widespread use in clinical practice. Therefore, peptide drugs can be modified to improve these disadvantages. Numerous studies have shown that alkyl-modified peptide drugs can self-assemble to prolong the duration of efficacy and/or reduce side effects. However, the commonly used solid-phase
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Analysing postprandial amino acid responses in crossover studies with the aaresponse package for R Amino Acids (IF 3.5) Pub Date : 2024-03-21 Ron Wehrens, Jasper Engel, Jurriaan Mes, Aard de Jong, Diederik Esser
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An insight into role of amino acids as antioxidants via NRF2 activation Amino Acids (IF 3.5) Pub Date : 2024-03-20 Melford C. Egbujor, Olugbemi T. Olaniyan, Chigbundu N. Emeruwa, Sarmistha Saha, Luciano Saso, Paolo Tucci
Oxidative stress can affect the protein, lipids, and DNA of the cells and thus, play a crucial role in several pathophysiological conditions. It has already been established that oxidative stress has a close association with inflammation via nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway. Amino acids are notably the building block of proteins and constitute the major class of
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Targeted metabolomic analysis of serum amino acids in heart failure patients Amino Acids (IF 3.5) Pub Date : 2024-03-14 Chunjing Yang, Zhengyuan Shi, Li Bao, Xiqiao Xv, Dechun Jiang, Longtai You
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GC–MS analysis of 4-hydroxyproline: elevated proline hydroxylation in metformin-associated lactic acidosis and metformin-treated Becker muscular dystrophy patients Amino Acids (IF 3.5) Pub Date : 2024-03-10 Svetlana Baskal, Rene A. Posma, Alexander Bollenbach, Willem Dieperink, Stephan J. L. Bakker, Maarten W. Nijsten, Daan J. Touw, Dimitrios Tsikas
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Prediction of matrilineal specific patatin-like protein governing in-vivo maternal haploid induction in maize using support vector machine and di-peptide composition Amino Acids (IF 3.5) Pub Date : 2024-03-09 Suman Dutta, Rajkumar U. Zunjare, Anirban Sil, Dwijesh Chandra Mishra, Alka Arora, Nisrita Gain, Gulab Chand, Rashmi Chhabra, Vignesh Muthusamy, Firoz Hossain
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Dietary branched-chain amino acids intake and new-onset hypertension: a nationwide prospective cohort study in China Amino Acids (IF 3.5) Pub Date : 2024-03-09 Lianlong Yu, Qianrang Zhu, Pengkun Song, Yuqian Li, Qingqing Man, Beibei Liu, Shanshan Jia, Jian Zhang
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Applications of biaryl cyclization in the synthesis of cyclic enkephalin analogs with a highly restricted flexibility Amino Acids (IF 3.5) Pub Date : 2024-03-01
Abstract A series of 10 cyclic, biaryl analogs of enkephalin, with Tyr or Phe residues at positions 1 and 4, were synthesized according to the Miyaura borylation and Suzuki coupling methodology. Biaryl bridges formed by side chains of the two aromatic amino acid residues are of the meta–meta, meta–para, para–meta, and para–para configuration. Conformational properties of the peptides were studied by
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SNAT2-mediated regulation of estrogen and progesterone in the proliferation of goat mammary epithelial cells Amino Acids (IF 3.5) Pub Date : 2024-02-23 Tingting Jiang, Xiaoyue Ma, Hanling Liu, Qianqian Jia, Jianguo Chen, Yi Ding, Ming Sun, Hongmei Zhu
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Hybrid 2D/3D-quantitative structure–activity relationship studies on the bioactivities and molecular mechanism of antibacterial peptides Amino Acids (IF 3.5) Pub Date : 2024-02-15 Qingguo Yan, Fangfang Wang, Bo Zhou, Xiangna Lin
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A novel lncRNA-hidden polypeptide regulates malignant phenotypes and pemetrexed sensitivity in A549 pulmonary adenocarcinoma cells Amino Acids (IF 3.5) Pub Date : 2024-02-13 Xiaobing Han, Liangxin Chen, Peng Sun, Xiuqing Wang, Qian Zhao, Lingfeng Liao, Dejin Lou, Nan Zhou, Yujun Wang
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Intersubunit communication in glycogen phosphorylase influences substrate recognition at the catalytic sites Amino Acids (IF 3.5) Pub Date : 2024-02-10
Abstract Glycogen phosphorylase (GP) is biologically active as a dimer of identical subunits, each activated by phosphorylation of the serine-14 residue. GP exists in three interconvertible forms, namely GPa (di-phosphorylated form), GPab (mono-phosphorylated form), and GPb (non-phosphorylated form); however, information on GPab remains scarce. Given the prevailing view that the two GP subunits collaboratively
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Lateralization of the 5-HT1A receptors in the basolateral amygdala in metabolic and anxiety responses to chronic restraint stress Amino Acids (IF 3.5) Pub Date : 2024-02-10 Habib Valipour, Gholam Hossein Meftahi, Gila Pirzad Jahromi, Alireza Mohammadi
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Identification and characterization of endogenous biomarkers for hepatic vectorial transport (OATP1B3-P-gp) function using metabolomics with serum pharmacology Amino Acids (IF 3.5) Pub Date : 2024-02-06 Yong-wen Jin, Yan-rong Ma, Ming-kang Zhang, Wen-bin Xia, Pei Yuan, Bo-xia Li, Yu-hui Wei, Xin-an Wu
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Antimicrobial and antitumor properties of anuran peptide temporin-SHf induce apoptosis in A549 lung cancer cells Amino Acids (IF 3.5) Pub Date : 2024-02-06 Anet Antony, Anupama Kizhakke Purayil, Shilpa Olakkaran, Shweta Dhannura, Shamasoddin Shekh, Konkallu Hanumae Gowd, Hunasanahally Puttaswamygowda Gurushankara
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Investigation of encapsulated water wire within self-assembled hydrophilic nanochannels, in a modified γ4-amino acid crystals: Tracking thermally induced changes of intermolecular interactions within a crystalline hydrate Amino Acids (IF 3.5) Pub Date : 2024-02-05 Krishnayan Basuroy, Jose de Jesus Velazquez-Garcia, Simone Techert
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The muscle protein synthetic response following corn protein ingestion does not differ from milk protein in healthy, young adults Amino Acids (IF 3.5) Pub Date : 2024-02-05 Philippe J. M. Pinckaers, Michelle E. G. Weijzen, Lisanne H. P. Houben, Antoine H. Zorenc, Imre W. K. Kouw, Lisette C. P. G. M. de Groot, Lex. B. Verdijk, Tim Snijders, Luc J. C. van Loon
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Investigating metabolic dysregulation in serum of triple transgenic Alzheimer’s disease male mice: implications for pathogenesis and potential biomarkers Amino Acids (IF 3.5) Pub Date : 2024-02-05
Abstract Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease that lacks convenient and accessible peripheral blood diagnostic markers and effective drugs. Metabolic dysfunction is one of AD risk factors, which leaded to alterations of various metabolites in the body. Pathological changes of the brain can be reflected in blood metabolites that are expected to explain the disease mechanisms
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The dual role of autophagy in the regulation of cancer treatment Amino Acids (IF 3.5) Pub Date : 2024-02-04 Louis Boafo Kwantwi
As a catabolic process, autophagy through lysosomes degrades defective and damaged cellular materials to support homeostasis in stressful conditions. Therefore, autophagy dysregulation is associated with the induction of several human pathologies, including cancer. Although the role of autophagy in cancer progression has been extensively studied, many issues need to be addressed. The available evidence
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d-Amino acids differentially trigger an inflammatory environment in vitro Amino Acids (IF 3.5) Pub Date : 2024-02-03 Siew Hwei Yap, Cheng Siang Lee, Nur Diyana Zulkifli, Darshinie Suresh, Kenji Hamase, Kumitaa Theva Das, Reena Rajasuriar, Kok Hoong Leong
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Molecular properties of linear amino acids in water Amino Acids (IF 3.5) Pub Date : 2024-02-01
Abstract Four linear amino acids of increased separation of the carboxyl and amino groups, namely glycine (aminoacetic acid), β-alanine (3-aminopropanoic acid), GABA (4-aminobutanoic acid) and DAVA (5-aminopentanoic acid), have been studied by quantum chemical ab initio and DFT methods including the solvent effect in order to get electronic structure and molecular descriptors, such as ionisation energy
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Amino acid distribution in blood following high-intensity interval exercise: a preliminary study Amino Acids (IF 3.5) Pub Date : 2024-02-01 Nattai Borges, Thomas M. Doering, Grace Murphy, Margaret Macdonald, Richard H. Dunstan
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Structure determination needs to go viral Amino Acids (IF 3.5) Pub Date : 2024-01-29 Matheus de Bastos Balbe e Gutierres, Conrado Pedebos, Paula Bacaicoa-Caruso, Rodrigo Ligabue-Braun
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Assessment of bioactive peptides derived from laminin-111 as prospective breast cancer-targeting agents Amino Acids (IF 3.5) Pub Date : 2024-01-29 Fernanda Ferreira Mendonça, Danielle Vieira Sobral, Ana Claudia Ranucci Durante, Ana Cláudia Camargo Miranda, Jorge Mejia, Daniele de Paula Faria, Fabio Luiz Navarro Marques, Marycel Figols de Barboza, Leonardo Lima Fuscaldi, Luciana Malavolta
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Heat shock interferes with the amino acid metabolism of bovine cumulus-oocyte complexes in vitro: a multistep analysis Amino Acids (IF 3.5) Pub Date : 2024-01-27 Hayder Radhi Hussein Mzedawee, Rasoul Kowsar, Reza Moradi-Hajidavaloo, Roya Shiasi-Sardoabi, Khaled Sadeghi, Mohammad Hossein Nasr-Esfahani, Mehdi Hajian
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Synthesis and glutathione peroxidase (GPx)-like activity of selenocystine (SeC) bioconjugates of biotin and lipoic acid Amino Acids (IF 3.5) Pub Date : 2023-11-16 Shakti K. Maurya, Abhishek Tripathi, Selvakumar Karuthapandi, Harkesh B. Singh
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Amino acid-stimulated insulin secretion: a path forward in type 2 diabetes Amino Acids (IF 3.5) Pub Date : 2023-11-15 Jelena Kolic, WenQing Grace Sun, James D. Johnson, Nicola Guess
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A novel antibacterial approach of Cecropin-B peptide loaded on chitosan nanoparticles against MDR Klebsiella pneumoniae isolates Amino Acids (IF 3.5) Pub Date : 2023-11-15 Hend Okasha, Heba Dahroug, Abdullah E. Gouda, Mohamed Abbas Shemis
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Safety assessment of L-Arg oral intake in healthy subjects: a systematic review of randomized control trials Amino Acids (IF 3.5) Pub Date : 2023-11-10 Yui Kuramochi, Mai Murata, Akihide Sumino, Hideko Sone, Kohsuke Hayamizu
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Potential of milk-derived bioactive peptides as antidiabetic, antihypertensive, and xanthine oxidase inhibitors: a comprehensive bibliometric analysis and updated review Amino Acids (IF 3.5) Pub Date : 2023-11-08 Emyr Hiago Bellaver, Aniela Pinto Kempka
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Investigating molecular interactions between human transferrin and resveratrol through a unified experimental and computational approach: Role of natural compounds in Alzheimer’s disease therapeutics Amino Acids (IF 3.5) Pub Date : 2023-11-05 Mohd Shahnawaz Khan, Mohammad Furkan, Moyad Shahwan, Dharmendra Kumar Yadav, Saleha Anwar, Rizwan Hasan Khan, Anas Shamsi
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Altered kynurenine pathway metabolism and association with disease activity in patients with systemic lupus Amino Acids (IF 3.5) Pub Date : 2023-11-05 Duygu Eryavuz Onmaz, Dilek Tezcan, Sema Yilmaz, Mustafa Onmaz, Ali Unlu
Systemic lupus erythematosus (SLE) is an autoimmune disease accompanied by increased release of proinflammatory cytokines that are known to activate the indoleamine 2,3-dioxygenase (IDO-1) enzyme, which catalyzes the rate-limiting step of the kynurenine pathway (KP). This study aimed to measure KP metabolite levels in patients with SLE and investigate the relationship between disease activity, clinical
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Effect of lipopeptide extracted from Bacillus licheniformis on the expression of bap and luxI genes in multi-drug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa Amino Acids (IF 3.5) Pub Date : 2023-10-31 Farangis Ghanipour, Razieh Nazari, Seyed Soheil Aghaei, Parvaneh Jafari
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Exploring details about structure requirements based on antioxidant tripeptide derived from β-Lactoglobulin by in silico approaches Amino Acids (IF 3.5) Pub Date : 2023-11-02 Fangfang Wang, Menghao Wen, Bo Zhou
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Acetylcholine hydrolytic activity of fibrillated β-amyloid (1–40) peptide Amino Acids (IF 3.5) Pub Date : 2023-10-30 Ivan Sanchis, Roque Spinelli, Alvaro Siano
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Predicted novel hypertrehalosaemic peptides of cockroaches are verified by mass spectrometry Amino Acids (IF 3.5) Pub Date : 2023-10-26 Heather G. Marco, Simone König, Gerd Gäde
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Serum albumin acted as an effective carrier to improve the stability of bioactive flavonoid Amino Acids (IF 3.5) Pub Date : 2023-10-19 Ya-Di Yang, Naihao Lu, Rong Tian
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Cross species review of the physiological role of d-serine in translationally relevant behaviors Amino Acids (IF 3.5) Pub Date : 2023-10-13 Dena Arizanovska, Jada A. Emodogo, Anna P. Lally, Caroline B. Palavicino-Maggio, Daniel J. Liebl, Oluwarotimi O. Folorunso
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Common pathogenic bacteria-induced reprogramming of the host proteinogenic amino acids metabolism Amino Acids (IF 3.5) Pub Date : 2023-10-09 Xiao-yue Li, Zi-xin Zeng, Zhi-xing Cheng, Yi-lin Wang, Liang-Jun Yuan, Zhi-yong Zhai, Wei Gong
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The possibilities of LOXL4 as a prognostic marker for carcinomas Amino Acids (IF 3.5) Pub Date : 2023-10-09 Jiaming Wang, Chaojian Chen, Jiayi Huang, Ziman Xie, Xiaoxue Chen, Ziqi Zheng, Enmin Li, Haiying Zou
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Binding of berberine to PEBP1 synergizes with sorafenib to induce the ferroptosis of hepatic stellate cells Amino Acids (IF 3.5) Pub Date : 2023-10-09 Zhongping Xie, Yu Zhou, Min Lin, Caihua Huang
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Mucosal-associated invariant T cells display both pathogenic and protective roles in patients with inflammatory bowel diseases Amino Acids (IF 3.5) Pub Date : 2023-10-11 Lei Wei, Zhigang Chen, Qiang Lv
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The renoprotective effects of taurine against diabetic nephropathy via the p38 MAPK and TGF-β/Smad2/3 signaling pathways Amino Acids (IF 3.5) Pub Date : 2023-10-07 Cemre Ural, Asli Celik, Seda Ozbal, Ensari Guneli, Sevki Arslan, Bekir Ugur Ergur, Caner Cavdar, Gül Akdoğan, Zahide Cavdar
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Bromelain and ficin proteolytic effects on gliadin cytotoxicity and expression of genes involved in cell-tight junctions in Caco-2 cells Amino Acids (IF 3.5) Pub Date : 2023-10-06 Masoumeh Sadat Mousavi Maleki, Hooman Aghamirza Moghim Ali Abadi, Behrooz Vaziri, Ali Akbar Shabani, Ghazaleh Ghavami, Hamid Madanchi, Soroush Sardari
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Synthesis and screening for anticancer activity of two novel telluro-amino acids: 1,3-Tellurazolidine-4-carboxylic acid and tellurohomocystine Amino Acids (IF 3.5) Pub Date : 2023-10-05 Abhishek Tripathi, Amreen Khan, Rohit Srivastava
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Peptide OA-VI12 restrains melanogenesis in B16 cells and C57B/6 mouse ear skin via the miR-122-5p/Mitf/Tyr axis Amino Acids (IF 3.5) Pub Date : 2023-10-04 Junsong Wang, Yilin Li, Chengan Feng, Haoyu Wang, Jiayi Li, Naixin Liu, Zhe Fu, Yinglei Wang, Yutong Wu, Yixiang Liu, Yingxuan Zhang, Saige Yin, Li He, Ying Wang, Xinwang Yang
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Effects of l-ascorbic acid (C6H8O6: Vit-C) on collagen amino acids: DFT study Amino Acids (IF 3.5) Pub Date : 2023-10-02 Uliana Y. Chugaeva, Mahmoud Raouf, Natalia S. Morozova, Leila Mahdavian
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An amino acid mixture, enriched with Krebs cycle intermediates, enhances extracellular matrix gene expression in cultured human fibroblasts Amino Acids (IF 3.5) Pub Date : 2023-09-28 Maurizio Ragni, Luca Canciani, Letizia Spataro, Chiara Ruocco, Alessandra Valerio, Enzo Nisoli
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Sodium pyruvate improves the plasma amino acid profile in rats with l-arginine-induced acute pancreatitis Amino Acids (IF 3.5) Pub Date : 2023-09-27 Anastasiia M. Zub, Roman D. Ostapiv, Bohdan O. Manko, Volodymyr V. Manko
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Molecular binding mechanism and novel antidiabetic and anti-hypertensive bioactive peptides from fermented camel milk with anti-inflammatory activity in raw macrophages cell lines Amino Acids (IF 3.5) Pub Date : 2023-09-25 Pratik Shukla, Amar Sakure, Bethsheba Basaiawmoit, Ruchita Khakhariya, Ruchika Maurya, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Zhenbin Liu, Srichandan Padhi, Amit Kumar Rai, Subrota Hati
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Branched-chain amino acid supplementation does not enhance lean tissue accretion in low birth weight neonatal pigs, despite lower Sestrin2 expression in skeletal muscle Amino Acids (IF 3.5) Pub Date : 2023-09-24 Joseph A. Yonke, Kacie A. Seymour, Samer W. El-Kadi
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Metabolomic profiling of amino acids study reveals a distinct diagnostic model for diabetic kidney disease Amino Acids (IF 3.5) Pub Date : 2023-09-22 Jiao Wang, Chunyu Zhou, Qing Zhang, Zhangsuo Liu
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Impact of chemical modifications on the antimicrobial and hemolytic activity of helical amphipathic peptide Lasioglossin LL-III Amino Acids (IF 3.5) Pub Date : 2023-09-22 Hai Bui Thi Phuong, Chi Le Uyen, Hoa Doan Ngan, Huy Luong Xuan