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Oleanolic acid: an antimycobacterial component of Syzygium aromaticum L. and inhibitor of efflux mediated drug resistance Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-18 Yassine El Ghallab, Mohamed Dakir, Achraf Aainouss, My Driss El Messaoudi, Sanae Derfoufi
Oleanolic acid (OA) was isolated from Syzygium aromaticum L. buds, and structurally characterised using different spectroscopic techniques; MS, IR,1H/13C-NMR and 2D NMR experiments. The antimycobac...
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Enhance the physicochemical properties of the citronella oil -SLNPs to improve the insecticidal activity against Spodoptera littoralis (Boisd) (Lep. Nactuidae) Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-18 Manal Mohamed Adel, Nagwa Yoseif Salem, Hany Mohamed Hussein
The Nano-formulation of citronella essential oil (Cymbopogon nardus (L.) and their mixtures of three adjuvants (Provecta®, Top film®, and PEG600-dioleate) were studied to enhance physico-chemical p...
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Hemisynthesis and cytotoxic evaluation of manoyl oxide analogs from sclareol: effect of two tertiary hydroxyls & Heck coupling on cytotoxicity Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-18 Ifshana Gani, Zahidul Islam Sofi, Gursimar Kaur, Anindya Goswami, Khursheed Ahmad Bhat
Sclareol, a bioactive diterpene alcohol isolated from Salvia sclarea, was subjected to structural modification and cytotoxic evaluation. Boron-Heck-coupled analogs of manoyl oxide were prepared fro...
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Essential oil of Eugenia stictopetala Mart. ex DC. has antioxidant, antibacterial, and gastrointestinal protective effect Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-18 Bruno Oliveira de Veras, Rianne Ferreira Felix, Geovanna Maria de Medeiros Moura, Daniela Maria do Amaral Ferraz Navarro, Júlio César Ribeiro de Oliveira Farias de Aguiar, Almir Gonçalves Wanderley, Márcia Vanusa da Silva, Maria Tereza dos Santos Correia
This work aimed to investigate the chemical composition, antioxidant capacity, antibacterial activity, and intestinal and gastric protective effects, in addition to the acute toxicity of the essent...
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Xanthine oxidase inhibitory constituents from the roots of Ampelopsis japonica Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-18 Yu-Lin Li, Fen Liu, Li-Yun Zhao, Han-Xiang Li, Aikebaier Jumai, Zhi-Fang Xu, Sheng-Xiang Qiu
Bioassay-guided purification of the xanthine oxidase (XOD) inhibitory extract of the roots of Ampelopsis japonica resulted in the isolation of two new triterpenoids (1-2), designated Ampejaponoside...
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Antimicrobial secondary metabolites and antioxidant activities of fungal endophytes associated with Ziziphus spina-christi (L.) Desf. (Nabq) leaves Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-17 Hala Montaser Farouk, Eman Zekry Attia, Gehan Mohamed Shaban, Usama Ramadan Abdelmohsen, Mo’men Hamed El-Katatny
A total of 20 endophytic fungi were isolated (ZSEFL1-ZSEFL20) from Ziziphus spina-christi (L.) Desf. (Nabq) leaves. Four isolates A2/ZSEFL2, Alternaria alternata, D/ZSEFL14, Aspergillus niger, E/ZS...
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Dihydrostilbenes from Macaranga javanica (Blume) Müll. Arg. and their antiplasmodial activity Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-17 Tjitjik Srie Tjahjandarie, Muhammad Fajar Aldin, Ratih Dewi Saputri, Mulyadi Tanjung
An undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) Müll. Arg. leaves. Macajav...
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Two new chemical constituents from the aerial parts of Tripterygium wilfordii Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-17 Xia Zhang, Lei Huang, Yu-Jun Tang, Ya-Lin Hu, Wei Xu, Hong-Yu Li, Yu-Bo Zhang, Xiao-Qi Zhang, Guang-Xiong Zhou
Tripterygium wilfordii has been historically employed as a conventional botanical insecticide and a plant of medicinal significance. A new dihydroagarofuran sesquiterpene (1) and a new acyclic comp...
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Efficient preparation of icariin from epimedin C by recyclable biphasic enzymatic hydrolysis Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-17 Wang Chen, Yue Zhang, Yuhang Zhang, Zili Feng, Xu He
Icariin is the most bioactive ingredient of Epimedium L. and a quality marker of Herba Epimedii. Conventional methods for production of Icariin are known to be inefficient, resulting in low yields ...
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Cyclopeptide alkaloids from the Greek shrub Paliurus spina-christi and their in silico binding affinity to Dipeptidyl Peptidase IV Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-17 Vaios Amountzias, Dennis Abatis, Antonios Drakopoulos, Grigoris Zoidis, Nektarios Aligiannis
A new cyclopeptide alkaloid, spinachristene A (1), along with two previously described, sanjoinenine (2) and oxyphylline C (3), were isolated from the fruits of Paliurus spina-christi Mill. All thr...
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Phytochemicals analysis and aflatoxin B1 detoxification potential of leaves extract of Moringa oleifera and Calotropis procera Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-16 Nehrish Nisar, Maryam Ajmal, Nafeesa Qudsia Hanif, Syed Waqas Hassan
The present study aimed to identify the presence of certain classes of phytochemicals in the leaf extract of medicinal herbs viz. Moringa oleifera and Calotropis procera, using qualitative detectio...
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The chemical composition of the aerial parts’ essential oil of Limonium lobatum (L.f.) Chaz. growing wild in Algeria Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-16 Larbi Derbak, Natale Badalamenti, Khellaf Rebbas, Bendif Hamdi, Maurizio Bruno
The Limonium genus (Plumbaginaceae) includes several species of perennial herbs and shrubs belonging to a particular type of halophytes, known as ‘recretohalophytes’. Limonium species are widely di...
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Study on the potential hypoglycemic flavonoids in Abrus precatorius leaves: purification process, quality profile and activity mechanisms by transcriptomics and network pharmacology Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-16 Xujiang Yuan, Xianmei Xue, Zhike Liang, Cuimin He
The aim of the study was to investigate the relationship between flavonoids in Abrus precatorius leaves (APL) and their hypoglycaemic effects, which have not been studied before. An efficient purif...
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Gigantol, a promising natural drug for inflammation: a literature review and computational based study Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-16 Raihan Chowdhury, Shimul Bhuia, Asraful Islam Rakib, Sakib Al Hasan, Manik Chandra Shill, Heba A. S. El-Nashar, Mohamed El-Shazly, Muhammad Torequl Islam
Gigantol, a bibenzyl compound extracted from various medicinal plants, has shown a number of biological activities, making it an attractive candidate for potential medical applications. This system...
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Neolignans with anti-inflammatory activity from Piper kadsura (Choisy) Ohwi Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-16 Xingxing Liu, Yi Wen, Xilei Wang, Yan Qi, Wenhao Zhou, Yijun Tu, Jiachuan Lei, Hong Cheng, Jianqing Yu
Two novel neolignans, piperkadsurenin A (1) and kadsurenin N (2), along with six known neolignans (3–8) and two lignans (9–10) were isolated from the stems of Piper kadsura (Choisy) Ohwi. Extensive...
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Exploring the potential of semi-synthetic Swertiamarin analogues for GLUT facilitation and insulin secretion in NIT-1 cell lines: a molecular docking and in-vitro study Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-15 Satyender Kumar, Prakash Niguram, Vinod Jairaj, Neelam Chauhan, Seema Jinagal, Sneha Sagar, Rakesh Kumar Sindhu, Amrish Chandra
Synthesis, characterisation, and anti-diabetic potential of swertiamarin analogues against DPP-4 enzymatic inhibition was done prior to this study. However, swertiamarin and its analogues inhibited...
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Phenolic constituents from the branches of Viburnum chinshanense as potential α-amylase and α-glucosidase inhibitory agents Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-15 Hong-Juan Zhou, Meng-Ya Yang, Jia Chen, Wei Ji, Jian-Hua Shao, Zi-Han Wang, Chun-Chao Zhao
This paper reports the isolation of two undescribed phenolic glycosides (1 and 2), together with seven known compounds (3–9) from the branches of Viburnum chinshanense. The structures of undescribe...
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Three new constituents from the stems of Knema globularia and their α-glucosidase inhibitory activity Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-13 Thi-Kim-Dung Le, Thuc-Huy Duong, Warinthorn Chavasiri
Three new metabolites (1−3) were isolated from the stems of Knema globularia, along with five known compounds, including kaempferol (4), quercetin (5), isovanillic acid (6), protocatechuic acid (7)...
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Essential oil of the leaves of psychotria asiatica L.: chemical composition, antioxidant, anti-inflammatory, and cytotoxic properties Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-13 Tien Dong Tran, Anh Tuan Le, Dat Van Tran, Thang Quoc Le, Ty Viet Pham
This study is focused on investigating the chemical composition and bioactive properties of the essential oil extracted from Psychotria asiatica L., a plant species known for its medicinal properti...
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A novel polycyclic quinazoline and three quinolines alkaloids from marine-derived fungus trichoderma longibrachiatum QD01 with anti-bacterial and anti-quorum sensing activities Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-13 Chaoyi Lv, Zhizhou Li, Shaohua Sun, Jiaying Ma, Hui Wang, Hu Zhu, Shiwei Sun, Wei Wang
A novel polycyclic quinazoline alkaloid (1) along with one new natural quinoline alkaloid (2) and two known quinoline alkaloids (3,4) were isolated from the marine-derived fungus Trichoderma longib...
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Paeonia mascula subsp. russoi (biv.) Cullen & Heywood: the chemical composition of the aerial parts essential oils of two different populations collected in Sicily (Italy) Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-13 Francesco Sgadari, Alessandro Vaglica, Antonella Porrello, Dario Savoca, Rosario Schicchi, Maurizio Bruno
In the present study, the chemical composition of the essential oil from aerial parts of two populations of Paeonia mascula subsp. russoi, collected in Sicily, was evaluated by GC–MS. No previously...
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Chemical constituents of açai berry pulp (Euterpe oleracea Mart.) by LC-UV-BPSU/NMR and LC-UV-SPE/NMR Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-13 Sérgio Scherrer Thomasi, Danilo Forti C. de Benedicto, Thayana da Conceição Alves, Bárbara Sayuri Bellete, Tiago Venâncio, Rafaella de Andrade Mattietto, Antonio Gilberto Ferreira
The techniques LC-UV-BPSU and LC-UV-SPE/NMR were applied for the first time in the analysis of açai berry (Euterpe oleracea Mart.) pulp extracts. Those techniques allowed the identification of twen...
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Characteristic volatile components analysis of Camelina sativa (L.) Crantz by GC-MS and their antibacterial and antioxidant activities Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-13 Feifei Li, Yuqing Liu, Jie Zhu, Zhining Li, Lixian Zhang, Yanni Ma, Liqin Yu
Camelina sativa (L.) Crantz is an oilseed plant common in Europe and Asia. This study used the gas chromatography–mass spectrometry (GC-MS) to examine the differences in the aroma on the basis of e...
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Flavan-3-ols, flavonoids, anthocyanidins and triterpenoids induces TIE2 phosphorylation -a candidate target for the vascular protective effects Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-12 Saki Igarashi, Sayaka Hioki, Naoto Sakamaru, Asahi Suzuki, Mihoko Kurokawa, Eisuke Kato
Vascular system is essential for the body to maintain health. Dysregulated vascular system leads to cardiovascular diseases and are observed in ischaemic stroke, Alzheimer’s disease, amyotrophic la...
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Effects of natural waste on in vitro oxidative DNA damage Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-12 Dua Danjolli-Hashani, Sebnem Selen Isbilir
In this study, the effects of natural waste products such as extracts from C. coggygria leaves and Punica granatum L. peels were investigated against oxidative DNA damage induced by Fenton reaction...
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Neuroprotective activity of Colocasia esculenta (L.) Schott leaves against monosodium glutamate-induced excitotoxicity in rats: phytochemical and molecular docking study Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-12 Heba T. Khazaal, Elsayed K. El-Sayed, Yara E. Mansour, Reham R. Ibrahim, Mokhtar Bishr, Rabab A. El Dib, Hesham S. M. Soliman
Colocasia esculenta (L.) Schott is a food crop with long history of use in treatment of various disorders including neurological diseases. The methanolic leaves extract (ME) and its n-butanol fract...
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Sucrose esters of aryldihydronaphthalene-type lignans, and antitumor activity of extracts of Moltkiopsis ciliata (Forssk.) aerial parts Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-11 Amal Mahmoud Youssef Moustafa, Mohamed Abdel-Moneim, Mohamed E. Mostafa, Mamdouh Abdel-Mogib, Marwa Rabee Abdel-Hak
One new compound (3f-[(7′R,8′R)-4,4′-dihydroxy-5-methoxy-2,7′-cycloligna-7-en-9-methoxycarbonyl, 9′-carbonyl-O-] -β- D-fructofuranosyl- (2→1)-α- D-glucopyranoside) (Moltkiopsin A) (2) was isolated ...
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Testusterol, a new sterol of the sponge species Xestospongia testudinaria from Phu Quoc island, Vietnam Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-11 Phuong Vu Luu, Hien Minh Nguyen, Phuc Minh Phan, An Duy Vo, Huong Lien Ton-Nu
A new sterol, named testusterol (1), and five known compounds (2-6) were isolated from the n-hexane and dichloromethane extracts of the sponge species Xestospongia testudinaria. Their chemical stru...
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Morusacerane: A new gammacerane triterpenoid from the trunk of Morus Alba linn. with α-glucosidase inhibitory activity Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-11 Hoang-Vinh-Truong Phan, Duy Vu Nguyen, Thi-Kim-Dung Le, Thi-Anh-Minh Nguyen, Phan-Si-Nguyen Dong, Thanh-Nha Tran, Ngoc-Van-Trang Dao, Hieu Cuong Nguyen, Hong Truong Luu, Warinthorn Chavasiri, Le-Thuy-Thuy-Trang Hoang, Van-Kieu Nguyen
This phytochemistry investigation on the trunk of Morus alba L. resulted in the isolation of three triterpenoids, including a new gammacerane triterpenoid – morusacerane (1); along with two known c...
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Antioxidant proficiency in Serbian mushrooms: a comparative study on Hydnum repandum L. 1753 from mycorrhizal and edible niches Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-10 Milena Rašeta, Jovana Mišković, Sanja Berežni, Saša Kostić, Marko Kebert, Milan Matavulj, Maja Karaman
This study aimed to evaluate the antioxidant potential of autochthonous Hydnum repandum through LC-MS/MS profiling, total phenolic content (TP), total protein content (TPR), and antioxidant capabil...
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Bacillus subtilis stimulates plant growth and production of bioactive components in saffron Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-10 Amir-Hossein Abedi, Hamid-Reza Adhami, Seyed Sadeq Mousavi Ghahfarrokhi, Masoud Mirmasoumi, Mohsen Amin
The effects of B. subtilis on the morphology and physiology of saffron were investigated using two types of soils. Three different bacterial suspensions were applied at 14-day intervals to treat sa...
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Fractionation and identification of bioactive compounds from a salt marsh plant Sesuvium potrucastrulam (L.) and its antioxidant activity Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-10 Ramamoorthy Purushothaman, Ganapathy Vishnuram, Thirugnanasambandam Ramanathan
Sesuvium portulacastrum (L.) is a fast-growing herbaceous perennial and halophyte belonging to the family Aizoaceae. Bioactive compound identification from halophytes is more helpful for the drug d...
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Quality control methods for fruit extracts of Kigelia africana using high performance thin layer chromatography Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-10 Kunjan B. Bodiwala, Nancy Banker, Rahul Lalwani, Mamta B. Shah, Anuradha K. Gajjar
Kigelia africana is a tree native to Africa but also found in eastern and southern parts of India with reported anti-bacterial, anti-inflammatory, and immunomodulatory activities. Verbascoside, caf...
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Antihyperlipidemic effect and GC-MS analysis of phytoconstituents from Laurus nobilis essential oil in rat Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-10 Ayoub Amssayef, Bouchra Soulaimani, Adil Qabouche, Abdelaziz Abbad, Mohamed Eddouks
This study aimed to evaluate the effect of Laurus nobilis (L. nobilis) essential oil (EOs) (80 mg/kg) on Triton WR-1339-induced dyslipidemia in Wistar rats. The effect of L. nobilis essential oil (...
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New steroids with anti-inflammatory activity from the whole plants of Physalis minima Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-10 Jiangping Wu, Qiuyue Lv, Jie Yu, Yu Zhang, Guodong Wang, Jun Han, Zhongmei Zou
Two new steroids, phyminiolide J (1) and phyministerol A (2), along with three known compounds (3–5) were isolated from the whole plants of Physalis minima. The structures of the new compounds were...
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A new triterpenoid saponin and a new natural saponin from the roots of Bupleurum scorzonerifolium willd Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-10 Zi-Wei Li, Jia-Tong Wu, Yu Bi, Meng-Meng Li, Anam Naseem, Juan Pan, Wei Guan, Zhi-Chao Hao, Hai-Xue Kuang, Qing-Shan Chen, Li-Li Zhang, Yan Liu, Bing-You Yang
Sixteen triterpenoid saponins were isolated from the roots of Bupleurum scorzonerifolium Willd., including a new triterpenoid saponin and new natural saponin that was characterised by NMR for the f...
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Preparation and characterisation of kaempferol composite carrier solid dispersion: evaluation of its application in preventing soybean oil spoilage Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-10 Tai Gao, Honghui Zhao, Lingling Wang, Danni Song, Xu Zhao
Kaempferol (KPF) can be used as a natural antioxidant and food additive in food processing. However, the poor solubility of KPF limited its bioavailability and application. In order to improve the ...
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Two new diketopiperazines from the marine sponge Dysidea sp. Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-09 Yu Lei, Xiao-Jian Liao, Xi-Wen Xing, Shi-Hai Xu, Bing-Xin Zhao
A chemical investigation on the marine sponge Dysidea sp. resulted in the isolation of a series of diketopiperazines, including two new compounds, dysidines A (1) and B (2) as well as six known one...
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Discovery of components in honeysuckle for treating COVID-19 and diabetes based on molecular docking, network analysis and experimental validation Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-09 Feng Xu, Ya Qin, Changxiu Guan
Molecular docking screening identified ochnaflavone, madreselvin B and hydnocarpin as key components for treating COVID-19 with diabetes in honeysuckle using 3 C-like protease (Mpro), angiotensin-c...
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Herbal alternatives: unveiling risks amidst the economic crisis Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-09 Salim Barakat, Carolla El Chamieh, Razan Dankar, Hachem Araji, Georges Khattar, Elie Bou Sanayeh
Published in Natural Product Research: Formerly Natural Product Letters (Ahead of Print, 2024)
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Antidiabetic effectiveness of Phyllanthus niruri bioactive compounds via targeting DPP-IV Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-09 Vinay Bhushan, Sudhanshu Kumar Bharti, Supriya Krishnan, Amit Kumar, Awanish Kumar
Phyllanthus niruri Linn. (Euphorbiaceae) is a small herb and is categorised as one of the rich medicinal plants throughout the world. This study aimed to evaluate the P. niruri L. whole plant extra...
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Artificial intelligence and natural product research Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Crist N. Filer
Published in Natural Product Research: Formerly Natural Product Letters (Ahead of Print, 2024)
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Cytotoxicity phenylpropanoid amides from the seed of Cannabis sativa L Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Ao-Fei Wang, Juan Pan, Xiang Liu, Xin-yuan Li, Peng Jiang, Meng-Meng Li, Wei Guan, Qing-Shan Chen, Li-li Zhang, Hai-Xue Kuang, Yan Liu, Bing-You Yang
Two novel phenylpropanoid amides, namely huomarenamide A (1) and huomarenamide B (2), along with twelve known compounds (3–14), were isolated from the seeds of Cannabis sativa L. The structures wit...
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Salvia rosmarinus: a possible role in unmet therapeutic needs in the prevention and care of immunological disorders Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Fabiana Furci, Nicola Cicero, Alessandro Allegra, Sebastiano Gangemi
Published in Natural Product Research: Formerly Natural Product Letters (Ahead of Print, 2024)
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A new illudane sesquiterpene from the edible fungus Pholiota nameko Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Lian Yang, Huan Zhang, Shu-Hang He, Ju Xu, Xiao-Long Li, Fei-Xing Li, Dong-Mei Lin, Deng-Ji Lou, Xiao-Yan Yang
Fungi have different genetic expression abilities and biosynthetic pathways under different cultivation conditions, which can produce various secondary metabolites. The “one strain many compounds” ...
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Discovery of olimycin E from Streptomyces sp. 11695 Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Lirong Tu, Shumei Shen, Zhenyang Yan, Xiaoxia Li, Kai Liu, Jin Xu, Minghe Luo
A new natural product olimycin E (1), together with two known compounds of divergolide R (2) and olimycin B (3), were obtained from the marine-derived Streptomyces sp. 11695. The structures of 1–3 ...
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Rapid identification and determination of chemical components of huai yam based on UPLC-Q-Exactive-MS and fragmentation patterns Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Huiru Liu, Xia Li, Haowei Xu, Xiaowen Wang, Zhimin Gong, Yanyan Xu, Lexin Shu, Yubo Li
Huai Yam (Dioscoreae Rhizoma) contains many active ingredients such as flavonoids, saponins, and amino acids. In this study, an efficient method for the classification and rapid identification of y...
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20-esterification of 5-spiro CPT and their anticancer activity in vitro Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Yuan Liu, Changkuo Zhao, Huimin Liu, Xianheng Wang
20-ester of 5-spirocycle campthothecin derivatives were successfully constructed and synthesised by Steglich esterification in a moderate yield. These derivatives showed a better solubility. Compar...
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Effects of plant extracts and derivatives on cardiac K+, Nav, and Cav channels: a review Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Insa Seck, Samba Fama Ndoye, Michelle Vanessa Kamga Kapchoup, Filomain Nguemo, Ismaila Ciss, Lalla Aicha Ba, Abda Ba, Seynabou Sokhna, Matar Seck
Natural products (NPs) are endless sources of compounds for fighting against several pathologies. Many dysfunctions, including cardiovascular disorders, such as cardiac arrhythmias have their modes...
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Chemical constituents of the aerial parts of Mitracarpus hirtus (L.) DC (Rubiaceae) Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Xinyi Wei, Yingrun Ma, Mingming Xu, Ding Heng, Monday M. Onakpa, Jin-Ao Duan, Chun-Tao Che, Hongkai Bi, Junfei Zhou, Ming Zhao
A phytochemical investigation of the aerial parts of Mitracarpus hirtus afforded thirteen compounds, including a new naphthoquinone di-glycoside (1), three isopentenyl isoflavones (2−4), four flavo...
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Natural alkaloids from Dicranostigma leptopodum (Maxim.) Fedde and their G5. NHAc-PBA dendrimer-alkaloid complexes for targeting chemotherapy in breast cancer MCF-7 cells Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Ye Tian, Zhiqiang Wang, Xu Xu, Yunqi Guo, Yanni Ma, Yanqi Lu, Mingwu Shen, Yang Geng, Helena Tomás, João Rodrigues, Ruilong Sheng
Herein, we isolated five natural alkaloids, iso-corydine (iso-CORY), corydine (CORY), sanguinarine (SAN), chelerythrine (CHE) and magnoflorine (MAG), from traditional medicinal herb Dicranostigma l...
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Chemical composition and biological activities of Pittosporum eriocarpum Royle: an unexplored medicinal plant of Indian himalayan region Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Khashti Dasila, Dheeraj Shootha, Mithilesh Singh
In this study, different parts (leaf, bark, and fruit) of Pittosporum eriocarpum were investigated to explore its chemical composition and biological activities. The GC-MS analysis confirmed the pr...
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(±)-Involucrasin D, a pair of enantiomeric bisflavonoid from the roots of Shuteria involucrata and its anti-inflammatory activity Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Xiaoying Zhou, Qiong Jin, Bingruo Zhang, Lisha Wei, Lue Bao, Xiaoyun Jiang, Rong Duan, Lu Liu, Zhuya Yang
An undescribed bisflavonoid, named involucrasin D (1), along with two known flavonoids, 2(S)7,3’,5’-trihydroxydihydroflavone (2) and sigmone (3) were isolated from the roots of Shuteria involucrata...
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Is berberine a natural oxempic? Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-08 Alishbah Anwar
Published in Natural Product Research: Formerly Natural Product Letters (Ahead of Print, 2024)
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C19-diterpene alkaloids from delphinium turkmenum lipsky Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-05 Abolfazl Shakeri, Maryam Samaei, Judit Hohmann, Milad Iranshahy, Javad Asili
The genus Delphinium is a rich source of diterpene alkaloids. Chemical investigation on an alkaloid rich extract of the whole parts of Delphinium turkmenum resulted in the isolation of three C19-di...
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Sesquiterpenoids and steroids from Eupatorium fortunei and their inhibitory effects on NO production Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-05 Lei Miao, Yin-Bo Pan, Shu-Ting Wang, Jun-Sheng Zhang, Hua Zhang
Two heterodimers including a clovane-phenylpropanoid hybrid (1) and a clovane-menthane hybrid (2), five linear sesquiterpenoids incorporating a tetrahydrofuran ring (3–6 & 8), and four steroids (7 ...
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Antifungal activity of extracts from Justicia species against Fusarium graminearum Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-05 Mariana del H. Sanchez Matías, Analía de los A. Gómez, Cristina M. Jiménez, Sarah Tanguy Guillo, María Eugenia del M. Aristimuño Ficoseco, César A.N. Catalán, Raphaël Grougnet, Marina Kritsanida, Diego A. Sampietro
Fusarium graminearum causes destructive ear rot diseases in maize and wheat. New antifungals are essential to combat this pathogen, and aerial parts of Justicia species (Acanthaceae) are a potentia...
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New anti-inflammatory limonoids from the fruits of Melia azedarach Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-04 Fan Cao, Jin-Huang Shen, Zhi-Jun Li, Wen-Lu Wang, Zhen-Wei Chen, Yong-Hong Zhang, Xin-Hua Ma
The phytochemical study of the fruits of Melia azedarach (Meliaceae) led to the isolation and characterisation of two novel natural limonoids1-deoxy- 3, 20-dicinnamoyl-11-methoxy-meliacarpinin (1) ...
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Rakicidin J and K, two cytotoxic and antibacterial cyclic depsipeptides from the marine bacterium Micromonospora chalcea Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-03 Li Chen, Lijun Xie, Jian Zhou, Dongsheng Fang, Honglei Jiang, Wei Liu, Yuqiu Ye, Wei Zhao, Hong Jiang, Feng Lin
Rakicidin J (1) and rakicidin K (2), two new cyclic depsipeptides, were isolated from culture broth of Micromonospora chalcea FIM-R150103. Their structures were elucidated by extensive analysis of ...
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Thrombin-induced platelet inhibition by 2′,4′-dihydroxychalcone and 2′,4′-dihydroxydihydrochalcone is mediated by inhibition of ROS production and Thromboxane synthase a activity: structure-activity relationship of polyphenol secondary metabolites from Empetrum nigrum Nat. Prod. Res. (IF 2.2) Pub Date : 2024-04-03 Ekaterina Fock, Nikita Pronin, Natalia Rukoyatkina, Anastasiia Whaley, Stepan Gambaryan, Andrei Whaley
In this study, we expanded our previous work by testing compounds 1–12 for their ability to inhibit platelet activation at low (30 µM) concentration by inhibition of ROS production, thromboxane syn...