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Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-18 Samuel A. Bradley, Frederik G. Hansson, Beata J. Lehka, Daniela Rago, Pedro Pinho, Huadong Peng, Khem B. Adhikari, Ahmad K. Haidar, Lea G. Hansen, Daria Volkova, Maxence Holtz, Sergi Muyo Abad, Xin Ma, Konstantinos Koudounas, Sébastien Besseau, Nicolas Gautron, Céline Mélin, Jillian Marc, Caroline Birer Williams, Vincent Courdavault, Emil D. Jensen, Jay D. Keasling, Jie Zhang, Michael K. Jensen
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Synthetic Vesicles for Sustainable Energy Recycling and Delivery of Building Blocks for Lipid Biosynthesis† ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-17 Eleonora Bailoni, Miyer F. Patiño-Ruiz, Andreea R. Stan, Gea K. Schuurman-Wolters, Marten Exterkate, Arnold J. M. Driessen, Bert Poolman
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Diffusion-Based Generative Network for de Novo Synthetic Promoter Design ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-13 Jianfeng Lin, Xin Wang, Tuoyu Liu, Yue Teng, Wei Cui
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Metabolic Engineering of Corynebacterium glutamicum for Highly Efficient Production of Ectoine ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-12 Zhi Ma, Renjie Chang, Linjiang Zhu, Dianhao Zhu, Yanfeng Deng, Xinying Guo, Ziyi Cheng, Xiaolong Chen
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Advances of Bacterial Biomaterials for Disease Therapy ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-12 Lin Zhai, Laiying Fu, Wei Wei, Diwei Zheng
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Scaling the Functional Nanopore (FuN) Screen: Systematic Evaluation of Self-Assembling Membrane Peptides and Extension with a K+-Responsive Fluorescent Protein Sensor ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-10 Klara Eisenhauer, Wadim Weber, Philipp Kemp, Carolin Gebhardt, Marwan Kaufmann, Noel Tewes, Hanna Zhdanova, Alesia Tietze, Oliver Rauh, Viktor Stein
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An Optimized Genotyping Workflow for Identifying Highly SCRaMbLEd Synthetic Yeasts ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-10 Timon A. Lindeboom, María del Carmen Sanchez Olmos, Karina Schulz, Cedric K. Brinkmann, Adán A. Ramírez Rojas, Lena Hochrein, Daniel Schindler
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Investigating the Effect of RNA Scaffolds on the Multicolor Fluorogenic Aptamer Pepper in Different Bacterial Species ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-09 Madeline M. Mumbleau, Fabienne Chevance, Kelly Hughes, Ming C. Hammond
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From Natural Microbe Screening to Sustained Chitinase Activity in Exogenous Hosts ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-08 Diptee Chaulagain, Narges S. Shamabadi, Skylar A. Leslie, David K. Karig
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Rational Engineering of Escherichia coli Nissle 1917 as Live Biotherapeutic to Degrade Uremic Toxin Precursors ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-08 David Lubkowicz, David L. Hava, Kim Lewis, Vincent M. Isabella
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RNA-Based Sensor Systems for Affordable Diagnostics in the Age of Pandemics ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-08 Ilkay Cisil Koksaldi, Dongwon Park, Abdurahman Atilla, Hansol Kang, Jongmin Kim, Urartu Ozgur Safak Seker
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A Proline-Based Artificial Enzyme That Favors Aldol Condensation Enables Facile Synthesis of Aliphatic Ketones via Tandem Catalysis ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-08 Ning Nie, Ziye Zhao, Xinwei Li, Yunting Liu, Yifei Zhang
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Bayesian Regression Facilitates Quantitative Modeling of Cell Metabolism ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-05 Teddy Groves, Nicholas Luke Cowie, Lars Keld Nielsen
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Engineering Plant Cell Fates and Functions for Agriculture and Industry ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-04 Connor Tansley, Nicola J. Patron, Sarah Guiziou
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Correction to “Directed Evolution of Aerotolerance in Sulfide-Dependent Thiazole Synthases” ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-04 Kristen Van Gelder, Edmar R. Oliveira-Filho, Jorge Donato García-García, You Hu, Steven D. Bruner, Andrew D. Hanson
The tables were not included in the published Supporting Information. Corrected Supporting Information is attached to this Correction. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acssynbio.4c00171. Figure S1. THI4 prescreening in the CEN6/ARS4 plasmid. Figure S2. Growth of populations harboring MhTHI4 or SfTHI4 during evolution campaigns. Figure S3. Nonsynonymous
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Overcoming Protein Orientation Mismatch Enables Efficient Nanoscale Light-Driven ATP Production ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-03 Andrea Marco Amati, Stefan Urs Moning, Sacha Javor, Sandra Schär, Sabina Deutschmann, Jean-Louis Reymond, Christoph von Ballmoos
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Programming Dynamic Division of Labor Using Horizontal Gene Transfer ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-03 Grayson S. Hamrick, Rohan Maddamsetti, Hye-In Son, Maggie L. Wilson, Harris M. Davis, Lingchong You
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Combining Rosetta Sequence Design with Protein Language Model Predictions Using Evolutionary Scale Modeling (ESM) as Restraint ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-03 Moritz Ertelt, Jens Meiler, Clara T. Schoeder
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Pyrococcus furiosus Argonaute Based Detection Assays for Porcine Deltacoronavirus ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-03 Yu Zhao, Tiejun Zhang, Changyu Zhou, Boyan Guo, Hongning Wang
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Enhancing Gastrodin Production in Yarrowia lipolytica by Metabolic Engineering ACS Synth. Biol. (IF 4.7) Pub Date : 2024-04-02 Yuanqing Wu, Shuocheng Li, Baijian Sun, Jingyi Guo, Meiyi Zheng, Aitao Li
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Using Protein Design and Directed Evolution to Monomerize a Bright Near-Infrared Fluorescent Protein ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-29 Xiuhong Hu, Yang Xu, Junxi Yi, Chenchen Wang, Zhongliang Zhu, Ting Yue, Haiyan Zhang, Xinyu Wang, Fan Wu, Lin Xue, Li Bai, Haiyan Liu, Quan Chen
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Engineering Compositionally Uniform Yeast Whole-Cell Biocatalysts with Maximized Surface Enzyme Density for Cellulosic Biofuel Production ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-29 Xiao Yin Ma, Bryan Coleman, Ponnandy Prabhu, Margaret Yang, Fei Wen
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Nano-Regulation of Gene Expression in Chlamydomonas reinhardtii: Harnessing AuNPs for Remotely Switchable Lipid Biosynthesis via Antisense Oligonucleotides ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-28 Nahid Rafiei, Hossein Alishah Aratboni, Abbas Alemzadeh, Santiago Saavedra-Alonso, Hooman Razi, José Rubén Morones-Ramírez
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Machine Learning-Guided Optimization of p-Coumaric Acid Production in Yeast ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-28 Sara Moreno-Paz, Rianne van der Hoek, Elif Eliana, Priscilla Zwartjens, Silvia Gosiewska, Vitor A. P. Martins dos Santos, Joep Schmitz, Maria Suarez-Diez
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Efficient Plant Triterpenoids Synthesis in Saccharomyces cerevisiae: from Mechanisms to Engineering Strategies ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-28 Shuai Wang, Dong Meng, Meilin Feng, Chun Li, Ying Wang
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Tyrosinase-Modified UHMW SELP Polymers as Wet and Underwater Adhesives to Achieve Multi-interface Adhesion ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-27 Wenxin Huang, Sijia Wang, Zhaoxuan Feng, Dasen Zhou, Wenqin Bai
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Building Synthetic Biosensors Using Red Blood Cell Proteins ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-27 Taylor B. Dolberg, Taylor F. Gunnels, Te Ling, Kelly A. Sarnese, John D. Crispino, Joshua N. Leonard
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Fluorescence-Based Screens for Engineering Enzymes Linked to Halogenated Tryptophan ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-27 Kevin B. Reed, Simon d’Oelsnitz, Sierra M. Brooks, Jordan Wells, Minye Zhao, Adit Trivedi, Selina Eshraghi, Hal S. Alper
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Building Synthetic Cells─From the Technology Infrastructure to Cellular Entities ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-26 Lynn J. Rothschild, Nils J. H. Averesch, Elizabeth A. Strychalski, Felix Moser, John I. Glass, Rolando Cruz Perez, Ibrahim O. Yekinni, Brooke Rothschild-Mancinelli, Garrett A. Roberts Kingman, Feilun Wu, Jorik Waeterschoot, Ion A. Ioannou, Michael C. Jewett, Allen P. Liu, Vincent Noireaux, Carlise Sorenson, Katarzyna P. Adamala
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Optimizing Nucleic Acid Delivery Systems through Barcode Technology ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-25 Soan Park, Mibang Kim, Jeong Wook Lee
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β-Dicarbonyls Facilitate Engineered Microbial Bromoform Biosynthesis ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-25 Thomas D. Loan, Claudia E. Vickers, Michael Ayliffe, Ming Luo
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Systematic Engineering of Escherichia coli for Efficient Production of Pseudouridine from Glucose and Uracil ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-26 Chi Zhang, Guoguang Wei, Ning Zhou, Yingying Wang, Jia Feng, Xin Wang, Alei Zhang, Kequan Chen
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Using High-Throughput Experiments To Screen N-Glycosyltransferases with Altered Specificities ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-25 Liang Lin, Weston Kightlinger, Katherine F. Warfel, Michael C. Jewett, Milan Mrksich
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Parageobacillus thermoglucosidasius Strain Engineering Using a Theophylline Responsive RiboCas for Controlled Gene Expression ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-22 Matthew S. H. Lau, Abubakar Madika, Ying Zhang, Nigel P. Minton
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Characterization of a Panel of Constitutive Promoters from Lactococcus cremoris for Fine-Tuning Gene Expression ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-22 Hui Wang, Lian-Zhong Ai, Yong-Jun Xia, Guang-Qiang Wang, Zhi-Qiang Xiong, Xin Song
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Streptomyces sungeiensis SD3 as a Microbial Chassis for the Heterologous Production of Secondary Metabolites ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-21 Sean Qiu En Lee, Guang-Lei Ma, Hartono Candra, Srashti Khandelwal, Li Mei Pang, Zhen Jie Low, Qing Wei Cheang, Zhao-Xun Liang
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Minimal Bacterial Cell JCVI-syn3B as a Chassis to Investigate Interactions between Bacteria and Mammalian Cells ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-20 Daniela Matias de C. Bittencourt, David M. Brown, Nacyra Assad-Garcia, Michaela R. Romero, Lijie Sun, Luis Alberto M. Palhares de Melo, Marcelo Freire, John I. Glass
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Circular Single-Stranded DNA: Discovery, Biological Effects, and Applications ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-19 Xisen Cao, Linlin Tang, Jie Song
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Pipetting Hand, Together ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-15 Kwanwoo Shin
Scientific progress relies on the maxim that scientific inquiry knows no bounds: new results and insights are not dependent on the location of the scientists who conducted the work. However, there is no similar guarantee that researchers in disparate locations will have equitable opportunities to participate in science. During a visit to the chemistry department at the Royal University of Phnom Penh
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A Yeast Modular Cloning (MoClo) Toolkit Expansion for Optimization of Heterologous Protein Secretion and Surface Display in Saccharomyces cerevisiae ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-14 Nicola M. O’Riordan, Vanja Jurić, Sarah K. O’Neill, Aoife P. Roche, Paul W. Young
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Retron Library Recombineering: Next Powerful Tool for Genome Editing after CRISPR/Cas ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-13 Navdeep Kaur, Pratap Kumar Pati
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Cell-Free Protein Expression in Polymer Materials ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-11 Marilyn S. Lee, Jennifer A. Lee, John R. Biondo, Jeffrey E. Lux, Rebecca M. Raig, Pierce N. Berger, Casey B. Bernhards, Danielle L. Kuhn, Maneesh K. Gupta, Matthew W. Lux
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Ensemble Detection of DNA Engineering Signatures ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-12 Aaron Adler, Joel S. Bader, Brian Basnight, Benjamin W. Booth, Jitong Cai, Elizabeth Cho, Joseph H. Collins, Yuchen Ge, John Grothendieck, Kevin Keating, Tyler Marshall, Anton Persikov, Helen Scott, Roy Siegelmann, Mona Singh, Allison Taggart, Benjamin Toll, Kenneth H. Wan, Daniel Wyschogrod, Fusun Yaman, Eric M. Young, Susan E. Celniker, Nicholas Roehner
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Engineered Saccharomyces cerevisiae as a Biosynthetic Platform of Nucleotide Sugars ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-11 Samantha A. Crowe, Xixi Zhao, Fei Gan, Xiaoyue Chen, Graham A. Hudson, Maria C. T. Astolfi, Henrik V. Scheller, Yuzhong Liu, Jay D. Keasling
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Discovery of Latent Cannabichromene Cyclase Activity in Marine Bacterial Flavoenzymes ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-08 Anna C. Love, Trevor N. Purdy, Felix M. Hubert, Ella J. Kirwan, Darren C. Holland, Bradley S. Moore
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Genome Engineering by RNA-Guided Transposition for Anabaena sp. PCC 7120 ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-06 Sergio Arévalo, Daniel Pérez Rico, Dolores Abarca, Laura W. Dijkhuizen, Cristina Sarasa-Buisan, Peter Lindblad, Enrique Flores, Sandra Nierzwicki-Bauer, Henriette Schluepmann
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Efficient Mutasynthesis of “Non-Natural” Antitubercular Ilamycins with Low Cytotoxicity ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-05 Yuyang Wang, Jianqiao He, Md Shah Alam, Fang Wang, Zhuo Shang, Yingying Chen, Changli Sun, Ziwen Lu, Yamin Gao, Tianyu Zhang, Jianhua Ju, Junying Ma
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Validation of Cell-Free Protein Synthesis Aboard the International Space Station ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-05 Selin Kocalar, Bess M. Miller, Ally Huang, Emily Gleason, Kathryn Martin, Kevin Foley, D. Scott Copeland, Michael C. Jewett, Ezequiel Alvarez Saavedra, Sebastian Kraves
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Enzymatic Assembly of Small Synthetic Genes with Repetitive Elements ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-04 Michael T. A. Nguyen, Martin Vincent Gobry, Néstor Sampedro Vallina, Georgios Pothoulakis, Ebbe Sloth Andersen
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Progress in Engineering Synthetic Cells and Cell-Free Systems ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-02 Marileen Dogterom, Neha P. Kamat, Michael C. Jewett, Katarzyna P. Adamala
What defines life, and how do living systems distinguish themselves from nonliving entities? Can life be fabricated from inert molecules? Those questions have been driving the rapid growth of a new area of synthetic biology: a groundbreaking scientific field centered on the construction of synthetic cells. This ambitious initiative aims to uncover deep insights into the fundamental principles of life
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Genetic Parts and Enabling Tools for Biocircuit Design ACS Synth. Biol. (IF 4.7) Pub Date : 2024-03-01 Felipe Buson, Yuanli Gao, Baojun Wang
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An Efficient Method for the Production of High-Purity Bioinspired Large Unilamellar Vesicles ACS Synth. Biol. (IF 4.7) Pub Date : 2024-02-29 Meline Macher, Amelie Obermeier, Sebastian Fabritz, Massimo Kube, Hannah Kempf, Hendrik Dietz, Ilia Platzman, Joachim P. Spatz
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Comprehensive Parameter Space Mapping of Cell Cycle Dynamics under Network Perturbations ACS Synth. Biol. (IF 4.7) Pub Date : 2024-02-29 Zhengda Li, Shiyuan Wang, Meng Sun, Minjun Jin, Daniel Khain, Qiong Yang
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Engineering Brassica Crops to Optimize Delivery of Bioactive Products Postcooking ACS Synth. Biol. (IF 4.7) Pub Date : 2024-02-27 Collin R. Barnum, Myeong-Je Cho, Kasey Markel, Patrick M. Shih
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Subunits of an E3 Ligase Complex as Degrons for Efficient Degradation of Cytosolic, Nuclear, and Membrane Proteins ACS Synth. Biol. (IF 4.7) Pub Date : 2024-02-26 Anže Verbič, Tina Lebar, Arne Praznik, Roman Jerala
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Codon-tRNA Coadaptation Bias for Identifying Strong Native Promoters in Komagataella phaffii ACS Synth. Biol. (IF 4.7) Pub Date : 2024-02-21 Louise La Barbera Kastberg, Mykhaylo S. Petrov, Tomas Strucko, Michael K. Jensen, Christopher T. Workman
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Light-Mediated Enhancement of Glucose-Stimulated Insulin Release of Optogenetically Engineered Human Pancreatic Beta-Cells ACS Synth. Biol. (IF 4.7) Pub Date : 2024-02-20 Zijing Chen, Demetrios M. Stoukides, Emmanuel S. Tzanakakis
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Highly Parallelized Construction of DNA from Low-Cost Oligonucleotide Mixtures Using Data-Optimized Assembly Design and Golden Gate ACS Synth. Biol. (IF 4.7) Pub Date : 2024-02-20 Sean Lund, Vladimir Potapov, Sean R. Johnson, Jackson Buss, Nathan A. Tanner
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Combinatorial Biosynthesis of 3-O-Carbamoylmaytansinol by Rational Engineering of the Tailoring Steps of Ansamitocins ACS Synth. Biol. (IF 4.7) Pub Date : 2024-02-20 Qingqing Liu, Yu Wang, Xin Xia, Zhongyue Li, Yaoyao Li, Yuemao Shen, Haoxin Wang
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LanTERN: A Fluorescent Sensor That Specifically Responds to Lanthanides ACS Synth. Biol. (IF 4.7) Pub Date : 2024-02-20 Ethan M. Jones, Yang Su, Chris Sander, Quincey A. Justman, Michael Springer, Pamela A. Silver