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Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-17 Robert I. Horne, Ewa A. Andrzejewska, Parvez Alam, Z. Faidon Brotzakis, Ankit Srivastava, Alice Aubert, Magdalena Nowinska, Rebecca C. Gregory, Roxine Staats, Andrea Possenti, Sean Chia, Pietro Sormanni, Bernardino Ghetti, Byron Caughey, Tuomas P. J. Knowles, Michele Vendruscolo
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Bringing chemistry to medicine to redefine the undruggable Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-12 Caitlin D. Deane, Marcus Fischer, Anang A. Shelat
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Peptide vaccines get an OS update Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-05 Martin Zacharias, Sebastian Springer
Peptide vaccines use antigenic peptide fragments to induce an immune response but are problematic because of the short half-life of peptides. A study now reports thioamide substitution in the peptide backbone as a strategy to enhance resistance to proteolysis and promote binding to the MHC I complex for T cell activation.
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LPS gets a fresh trim Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-01 Gemma Banister, Dave Boucher
Detection of intracellular lipolysaccharide (LPS) activates an immune response initiated by the non-canonical inflammasome. ATGL has now been identified as a negative regulator of this pathway that dampens inflammation by removing LPS’ acyl chains, preventing the activation of inflammatory caspases and cytokines.
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Engineering APOBEC3A deaminase for highly accurate and efficient base editing Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-29 Lei Yang, Yanan Huo, Man Wang, Dan Zhang, Tianai Zhang, Hao Wu, Xichen Rao, Haowei Meng, Shuming Yin, Jiale Mei, Dexin Zhang, Xi Chen, Jia Lv, Meizhen Liu, Yiyun Cheng, Yuting Guan, Bo Feng, Gaojie Song, Chengqi Yi, Mingyao Liu, Fanyi Zeng, Liren Wang, Dali Li
Cytosine base editors (CBEs) are effective tools for introducing C-to-T base conversions, but their clinical applications are limited by off-target and bystander effects. Through structure-guided engineering of human APOBEC3A (A3A) deaminase, we developed highly accurate A3A-CBE (haA3A-CBE) variants that efficiently generate C-to-T conversion with a narrow editing window and near-background level of
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Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-27 Min Li, Zheng Wang, Jingjing Tao, Hongfei Jiang, Huang Yang, Dong Guo, Hong Zhao, Xuxiao He, Shudi Luo, Xiaoming Jiang, Li Yuan, Liwei Xiao, Haiyan He, Rilei Yu, Jing Fang, Tingbo Liang, Zhengwei Mao, Daqian Xu, Zhimin Lu
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The death gaze of MEDUSA Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-26 Jesse D. Gelles, Jerry Edward Chipuk
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Reeling in microorganisms Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-25 Gene Chong
The metabolic engineering of microorganisms is an attractive platform for bioremediation and the industrial production of chemicals. However, biocontainment strategies are needed if genetically modified organisms are to be released into open environments. Hoffmann and Cai report a biocontainment strategy in yeast based on targeted protein degradation. The authors performed high-throughput screening
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Profiling the proximal proteome of the activated μ-opioid receptor Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-25 Benjamin J. Polacco, Braden T. Lobingier, Emily E. Blythe, Nohely Abreu, Prachi Khare, Matthew K. Howard, Alberto J. Gonzalez-Hernandez, Jiewei Xu, Qiongyu Li, Brandon Novy, Zun Zar Chi Naing, Brian K. Shoichet, Willow Coyote-Maestas, Joshua Levitz, Nevan J. Krogan, Mark Von Zastrow, Ruth Hüttenhain
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Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-25 Yi Fan Chen, Maryam Ghazala, Ryan M. Friedrich, Brittany A. Cordova, Frederick N. Petroze, Ramya Srinivasan, Kevin C. Allan, David F. Yan, Joel L. Sax, Kelley Carr, Suzanne L. Tomchuck, Yuriy Fedorov, Alex Y. Huang, Amar B. Desai, Drew J. Adams
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Stress it up Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-25 Grant Miura
AKT is a serine/threonine kinase that is essential for cellular metabolism and proliferation and is overactive in cancer cells. Small molecule catalytic inhibitors of all three AKT isoforms, as well as selective AKT degraders, have been developed, but the therapeutic efficacy of these compounds remains less than optimal. In particular, existing AKT degraders such as INY-03-041 elicit slow degradation
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Switching off the stress response Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-25 Yiyun Song
Cells respond to adverse environmental changes by activating stress response pathways. However, the continuous activation of stress responses can lead to unwanted cell death or damage to necessary biological functions, and it is not clear how stress response pathways are turned off once the condition improves. Haakonsen et al. have now reported the discovery of an E3 complex that switches off the stress
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Global signal peptide profiling reveals principles of selective Sec61 inhibition Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-22 Nicole A. Wenzell, Brian B. Tuch, Dustin L. McMinn, Matthew J. Lyons, Christopher J. Kirk, Jack Taunton
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Sulfide oxidation promotes hypoxic angiogenesis and neovascularization Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-20 Roshan Kumar, Victor Vitvitsky, Apichaya Sethaudom, Rashi Singhal, Sumeet Solanki, Sydney Alibeckoff, Harrison L. Hiraki, Hannah N. Bell, Anthony Andren, Brendon M. Baker, Costas A. Lyssiotis, Yatrik M. Shah, Ruma Banerjee
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Ripping and stitching with copper Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-21 Ninian J. Blackburn
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Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-21 Hai-Tsang Huang, Ryan J. Lumpkin, Ryan W. Tsai, Shuyao Su, Xu Zhao, Yuan Xiong, James Chen, Nada Mageed, Katherine A. Donovan, Eric S. Fischer, William R. Sellers
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Design of amyloidogenic peptide traps Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-19 Danny D. Sahtoe, Ewa A. Andrzejewska, Hannah L. Han, Enrico Rennella, Matthias M. Schneider, Georg Meisl, Maggie Ahlrichs, Justin Decarreau, Hannah Nguyen, Alex Kang, Paul Levine, Mila Lamb, Xinting Li, Asim K. Bera, Lewis E. Kay, Tuomas P. J. Knowles, David Baker
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Accessing natural vaccine adjuvants Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-15 Vincent Courdavault, Nicolas Papon
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Functional genomic screens with death rate analyses reveal mechanisms of drug action Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-13 Megan E. Honeywell, Marie S. Isidor, Nicholas W. Harper, Rachel E. Fontana, Gavin A. Birdsall, Peter Cruz-Gordillo, Sydney A. Porto, Madison Jerome, Cameron S. Fraser, Kristopher A. Sarosiek, David A. Guertin, Jessica B. Spinelli, Michael J. Lee
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De novo-designed transmembrane proteins bind and regulate a cytokine receptor Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-13 Marco Mravic, Li He, Huong T. Kratochvil, Hailin Hu, Sarah E. Nick, Weiya Bai, Anne Edwards, Hyunil Jo, Yibing Wu, Daniel DiMaio, William F. DeGrado
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Breaking the deadlock in genetic code expansion Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-11 Ya-Ming Hou, Yuko Nakano
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A solid beta-sheet structure is formed at the surface of FUS droplets during aging Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-11 Leonidas Emmanouilidis, Ettore Bartalucci, Yelena Kan, Mahdiye Ijavi, Maria Escura Pérez, Pavel Afanasyev, Daniel Boehringer, Johannes Zehnder, Sapun H. Parekh, Mischa Bonn, Thomas C. T. Michaels, Thomas Wiegand, Frédéric H.-T. Allain
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Aerobic glycolysis comes with an enzyme cost but robustness gain Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-08
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DNA-functionalized artificial mechanoreceptor for de novo force-responsive signaling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-06 Sihui Yang, Miao Wang, Dawei Tian, Xiaoyu Zhang, Kaiqing Cui, Shouqin Lü, Hong-hui Wang, Mian Long, Zhou Nie
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Big data and benchmarking initiatives to bridge the gap from AlphaFold to drug design Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-08 Matthieu Schapira, Levon Halabelian, Cheryl H. Arrowsmith, Rachel J. Harding
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Hijacking endogenous mRNA for genetic code expansion Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-07 Tomohiro Doura, Yuma Matsuoka, Shigeki Kiyonaka
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Mitochondrial ATP generation is more proteome efficient than glycolysis Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-06 Yihui Shen, Hoang V. Dinh, Edward R. Cruz, Zihong Chen, Caroline R. Bartman, Tianxia Xiao, Catherine M. Call, Rolf-Peter Ryseck, Jimmy Pratas, Daniel Weilandt, Heide Baron, Arjuna Subramanian, Zia Fatma, Zong-Yen Wu, Sudharsan Dwaraknath, John I. Hendry, Vinh G. Tran, Lifeng Yang, Yasuo Yoshikuni, Huimin Zhao, Costas D. Maranas, Martin Wühr, Joshua D. Rabinowitz
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Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-03-05 Qinheng Zheng, Ziyang Zhang, Keelan Z. Guiley, Kevan M. Shokat
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Friend or foe-maldehyde Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-29 Vicki L. Emms, Sara Y. Chothia, Richard J. Hopkinson
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In situ analysis of osmolyte mechanisms of proteome thermal stabilization Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-29 Monika Pepelnjak, Britta Velten, Nicolas Näpflin, Tatjana von Rosen, Umberto Capasso Palmiero, Jeong Hoon Ko, Heather D. Maynard, Paolo Arosio, Eilika Weber-Ban, Natalie de Souza, Wolfgang Huber, Paola Picotti
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Antiviral drug recognition and elevator-type transport motions of CNT3 Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-28 Nicholas J. Wright, Feng Zhang, Yang Suo, Lingyang Kong, Ying Yin, Justin G. Fedor, Kedar Sharma, Mario J. Borgnia, Wonpil Im, Seok-Yong Lee
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Programmable RNA base editing via targeted modifications Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-28 Jinghui Song, Yuan Zhuang, Chengqi Yi
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Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-27 Weitao Li, Qiannv Liu, Yan Qian, Chunlei Wang, Chun Kong, Liangliang Sun, Li Sun, Hongwei Liu, Yan Zhang, Dong Jiang, Changtao Jiang, Shuo Wang, Pengyan Xia
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Discovery of metal-binding proteins by thermal proteome profiling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-26 Xin Zeng, Tiantian Wei, Xianghe Wang, Yuan Liu, Zhenshu Tan, Yihai Zhang, Tianyu Feng, Yao Cheng, Fengzhang Wang, Bin Ma, Wei Qin, Chuanping Gao, Junyu Xiao, Chu Wang
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Lights on for lipid metabolism Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-21 Francesco Zamberlan
Phosphatidic acid is a pleiotropic lipid involved in lipid transport across different cellular organelles as well as major cellular signaling pathways through its metabolism. However, understanding and mapping its physiological functions require methods that can detect its rapid spatial concentration changes. Optogenetic membrane editors based on the biosynthesis of phosphatidic acid using phospholipase
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A tale of two lipids Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-21 Gene Chong
Original reference: ACS Chem. Biol. https://doi.org/10.1021/acschembio.3c00554 (2024)
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Death pools Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-21 Grant Miura
Original reference: Mol. Cell https://doi.org/10.1016/j.molcel.2023.12.041 (2024)
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The druggability of SH2 domains unmasked Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-15 Oliver Hantschel
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Post-translational glycosylation diminishes α-synuclein pathology formation Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-14
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O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-12 Aaron T. Balana, Anne-Laure Mahul-Mellier, Binh A. Nguyen, Mian Horvath, Afraah Javed, Eldon R. Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M.-Y. Lee, Kelvin C. Luk, Lorena Saelices, Hilal A. Lashuel, Matthew R. Pratt
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Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-14 Yasmeen J. Solano, Michael P. Everett, Kelly S. Dang, Jude Abueg, Philip D. Kiser
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An intramolecular macrocyclase in plant ribosomal peptide biosynthesis Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-14 Lisa S. Mydy, Jordan Hungerford, Desnor N. Chigumba, Jamie R. Konwerski, Sarah C. Jantzi, Di Wang, Janet L. Smith, Roland D. Kersten
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Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-14 Xiaoyu Zhou, Cheng Zhao, Haiyan Xu, Yixiang Xu, Li Zhan, Pei Wang, Jingyi He, Taotao Lu, Yueling Gu, Yan Yang, Chanjuan Xu, Yiyang Chen, Yuxuan Liu, Yue Zeng, Fuyun Tian, Qian Chen, Xin Xie, Jianfeng Liu, Hailan Hu, Jian Li, Yueming Zheng, Jiangtao Guo, Zhaobing Gao
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High-throughput engineering of biosynthetic assembly lines Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-12
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Host–microbiome orchestration of the sulfated metabolome Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-12 Gabriel D. D’Agostino, Snehal N. Chaudhari, A. Sloan Devlin
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Fast and sensitive CRISPR detection by minimized interference of target amplification Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-08 Xiaohan Tong, Kun Zhang, Yang Han, Tianle Li, Min Duan, Ruijin Ji, Xianguang Wang, Xi Zhou, Ying Zhang, Hao Yin
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Micropolarized to the core Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-07 My Diem Quan, Josephine C. Ferreon, Allan Chris M. Ferreon
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Flipping hemagglutinin on its head Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-06 James A. Ferguson, Julianna Han, Andrew B. Ward
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Immobilized enzyme cascade for targeted glycosylation Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-06 Elli Makrydaki, Roberto Donini, Anja Krueger, Kate Royle, Ignacio Moya Ramirez, Douglas A. Kuntz, David R. Rose, Stuart M. Haslam, Karen M. Polizzi, Cleo Kontoravdi
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Mapping microhabitats of lignocellulose decomposition by a microbial consortium Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-01 Marija Veličković, Ruonan Wu, Yuqian Gao, Margaret W. Thairu, Dušan Veličković, Nathalie Munoz, Chaevien S. Clendinen, Aivett Bilbao, Rosalie K. Chu, Priscila M. Lalli, Kevin Zemaitis, Carrie D. Nicora, Jennifer E. Kyle, Daniel Orton, Sarai Williams, Ying Zhu, Rui Zhao, Matthew E. Monroe, Ronald J. Moore, Bobbie-Jo M. Webb-Robertson, Lisa M. Bramer, Cameron R. Currie, Paul D. Piehowski, Kristin E.
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High-throughput reprogramming of an NRPS condensation domain Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-02 Ines B. Folger, Natália F. Frota, Angelos Pistofidis, David L. Niquille, Douglas A. Hansen, T. Martin Schmeing, Donald Hilvert
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Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4 Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-02 Xin Zhou, Sophie Kong, Allison Maker, Soumya G. Remesh, Kevin K. Leung, Kliment A. Verba, James A. Wells
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Lighting up kinase contacts in situ Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-01 Guochao Chu, Yi-Ming Li
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Tracking endogenous proteins based on RNA editing-mediated genetic code expansion Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-02-01 Min Hao, Xinyu Ling, Yi Sun, Xue Wang, Wenzhe Li, Liying Chang, Zhiying Zeng, Xiaomeng Shi, Mengxiao Niu, Liangyi Chen, Tao Liu
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PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-01-29 Qianping Zhang, Tiantian Sun, Fan Yu, Wei Liu, Jin Gao, Jinyu Chen, Hao Zheng, Jinming Liu, Chenjian Miao, Huanyi Guo, Wu Tian, Meihui Su, Yingjie Guo, Xi Liu, Yandong Pei, Zhuofei Wang, Shang Chen, Chenglong Mu, Sin Man Lam, Guanghou Shui, Zongjin Li, Zhongbo Yu, Yan Zhang, Guo Chen, Congcong Lu, Adam C. Midgley, Changhua Li, Xin Bian, Xudong Liao, Yong Wang, Wei Xiong, Hongying Zhu, Yanjun Li, Quan