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Synthesis and Characterization of Paclitaxel-Loaded Silver Nanoparticles: Evaluation of Cytotoxic Effects and Antimicrobial Activity Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2024-2-13 Tutku Tunç, Ceylan Hepokur, Afşin Kari̇per
Carrier system therapies based on combining cancer drugs with nanoparticles have been reported to control tumor growth and significantly reduce the side effects of cancer drugs. We thought that paclitaxel-loaded silver nanoparticles (AgNPs-PTX) were the right carrier to target cancer cells. We also carried out antimicrobial activity experiments as systems formed with nanoparticles have been shown to
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Mitochondria-Targeting and Oxygen Self-Supplying Eccentric Hollow Nanoplatform for Enhanced Breast Cancer Photodynamic Therapy Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2024-2-1 Jing Li, Yu Wang, Jun Tao, Xiaodan Su, Feipeng Zhu, Wei Lu, Xiaolin Han, Meng Dang, Lixing Weng
Photodynamic therapy (PDT) has received increasing attention for tumor therapy due to its minimal invasiveness and spatiotemporal selectivity. However, the poor targeting of photosensitizer and hypoxia of the tumor microenvironment limit the PDT efficacy. Herein, eccentric hollow mesoporous organic silica nanoparticles (EHMONs) are prepared by anisotropic encapsulation and hydrothermal etching for
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Different Degrees of Sulfated Laminaria Polysaccharides Recovered Damaged HK-2 Cells and Inhibited Adhesion of Nano-COM and Nano-COD Crystals Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2024-1-2 Qiu-Shi Xu, Zhi-Jian Wu, Jian-Ming Sun, Jing-Hong Liu, Wei-Bo Huang, Jian-Ming Ouyang
Purpose. The crystal adhesion caused by the damage of renal tubular epithelial cells (HK-2) is the key to the formation of kidney stones. However, no effective preventive drug has been found. This study aims to explore the recovery effects of four Laminaria polysaccharides (SLPs) with different sulfate (–OSO3–) contents on damaged HK-2 cells and the difference in the adhesion of damaged cells to nanometer
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Antioxidant Activity of Auricularia auricula Polysaccharides with Different Molecular Weights and Cytotoxicity Difference of Polysaccharides Regulated CaOx to HK-2 Cells Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-12-23 Bao-Li Heng, Fan-Yu Wu, Jing-Hong Liu, Jian-Ming Ouyang
Objective. This study aimed to investigate the growth of calcium oxalate (CaOx) crystals regulated by Auricularia auricular polysaccharides (AAPs) with different viscosity-average molecular weights (), the toxicity of AAP-regulated CaOx crystals toward HK-2 cells, and the prevention and treatment capabilities of AAPs for CaOx stones. Methods. The scavenging capability and reducing capacity of four
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In Situ Green Synthesis of Co3O4@ZnO Core-Shell Nanoparticles Using Datura stramonium Leaf Extract: Antibacterial and Antioxidant Studies Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-11-29 Gezahegn Tadesse, H. C. Ananda Murthy, C. R. Ravikumar, T. Naveen Kumar, Lema Teshome, Tegene Desalegn
Investigating and synthesizing potent antibacterial NPs using biological methods is highly preferred, and it involves nontoxic, cost-effective, and environmentally friendly chemicals and methods. Antibiotic drug resistance and oxidative stress have become a serious public health issue worldwide. Hence, the key objective of this study was to biologically synthesize and characterize the potent antibacterial
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An Overview of Supramolecular Platforms Boosting Drug Delivery Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-11-13 Rosa Bellavita, Simone Braccia, Annarita Falanga, Stefania Galdiero
Numerous supramolecular platforms inspired by natural self-assembly are exploited as drug delivery systems. The spontaneous arrangement of single building blocks into inorganic and organic structures is determined and controlled by noncovalent forces such as electrostatic interactions, π-π interactions, hydrogen bonds, and van der Waals interactions. This review describes the main structures and characteristics
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New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-10-25 Elizabeth Gómez, José Miguel Galván-Hidalgo, Guillermo Pérez-Cuéllar, Karoline Alondra Huerta-Landa, Arturo González-Hernández, Omar Gómez-García, Dulce Andrade-Pavón, Teresa Ramírez-Apan, Karla Daniela Rodríguez Hernández, Simón Hernández, Patricia Cano-Sánchez, Homero Gómez-Velasco
Organotin complexes were prepared through a one-pot reaction with three components by reacting thiosemicarbazide or 4-methyl-3-thiosemicarbazide or 4-phenylthiosemicarbazide, dehydroacetic acid (DHA) and dibutyl, diphenyl, dicyclohexyl, and bis[(trimethylsilyl)methyl]tin(IV) oxides; all complexes were characterized by infrared (IR), ultraviolet-visible (UV-vis), mass spectrometry (MS), and nuclear
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Precise Construction of Dual-Promising Anticancer Drugs Associated with Gold Nanomaterials on Glioma Cancer Cells Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-10-25 P. Baby Shakila, Abdurahman Hajinur Hirad, Abdullah A. Alarfaj, Samer Hasan Hussein-Al-Ali, Beza Mulugeta
Multiple chemodrugs with nanotechnology have proven to be an effective cancer treatment technique. When taken combined, cabazitaxel (CTX) and cisplatin (PT) have more excellent cytotoxic effects than drugs used alone in the chemotherapy of several different cancers. However, several severe side effects are associated with using these chemotherapy drugs in cancer patients. Gold nanomaterials (AuNMs)
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Effect of Capping Agent on Structure, Composition, and Optical Properties of Low-Cost Chemically Deposited Zinc Oxide Thin Films and Their Antibacterial Activities Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-10-23 S. Thanikaikarasan, C. Amutha, B. Natarajan, D. Dhanasekaran, S. Rajkumar
In the present report, pure zinc oxide and albumen-capped zinc oxide thin films were deposited on a glass substrate by a simple chemical method. The growth rate of the deposited film increases by means of number of dipping linearly. The films deposited were subjected to XRD, SEM, EDX, and UV-visible spectroscopy to analyze the crystal structure, morphology, composition, and optical properties. Structural
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Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-9-28 Andres Alguacil, Franco Scalambra, Antonio Romerosa, Andreia Bento-Oliveira, Fernanda Marques, Ines Maximiano, Rodrigo F. M. de Almeida, Ana Isabel Tomaz, Andreia Valente
Piano-stool-{CpRu} complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA), N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA), and 3,7-dimethyl-1,3,7-triaza-5-phosphabyciclo[3.3.1]nonane (dmoPTA) were evaluated as drugs against breast cancer. The evaluated compounds include two new examples of this family, the complexes [RuCp(DMSO-κS)(HdmoPTA)(PPh3)](CF3SO3)2 (8) and [RuCp(PPh3)2-µ-dmoPTA-1κP-2κ2N
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Lepidium sativum Seed Extract-Mediated Synthesis of Zinc Oxide Nanoparticles: Structural, Morphological, Optical, Hemolysis, and Antibacterial Studies Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-9-22 Adnan Alnehia, Annas Al-Sharabi, Abdel-Basit Al-Odayni, A. H. Al-Hammadi, Fares H. AL-Ostoot, Waseem Sharaf Saeed, Naaser A. Y. Abduh, Ali Alrahlah
Nanomaterials have unique physicochemical properties compared to their bulk counterparts. Besides, biologically synthesized nanoparticles (NPs) have proven superior to other methods. This work aimed to biosynthesize zinc oxide (ZnO) NPs using an aqueous extract of Lepidium sativum seed. The obtained ZnO NPs were characterized by X-ray diffraction, scanning electron microscopy, Fourier transform infrared
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Evaluation of the Antitumor Effects of Platinum-Based [Pt(η1-C2H4-OR)(DMSO)(phen)]+ (R = Me, Et) Cationic Organometallic Complexes on Chemoresistant Pancreatic Cancer Cell Lines Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-9-11 Erika Stefàno, Luca Giulio Cossa, Federica De Castro, Erik De Luca, Viviana Vergaro, Giulia My, Gianluca Rovito, Danilo Migoni, Antonella Muscella, Santo Marsigliante, Michele Benedetti, Francesco Paolo Fanizzi
Pancreatic cancer is one of the most lethal malignancies with an increasing incidence and a high mortality rate, due to its rapid progression, invasiveness, and resistance to anticancer therapies. In this work, we evaluated the antiproliferative and antimigratory activities of the two organometallic compounds, [Pt(η1-C2H4-OMe)(DMSO)(phen)]Cl (1) and [Pt(η1-C2H4-OEt)(DMSO)(phen)]Cl (2), on three human
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Retracted: Study on Nano Drug Particles in the Diagnosis and Treatment of Alzheimer's Disease in the Elderly. Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-08-16 Bioinorganic Chemistry And Applications
[This retracts the article DOI: 10.1155/2022/3335581.].
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Magnetic Activated Carbon from ZnCl2 and FeCl3 Coactivation of Lotus Seedpod: One-Pot Preparation, Characterization, and Catalytic Activity towards Robust Degradation of Acid Orange 10 Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-6-6 Dung Van Nguyen, Hung Minh Nguyen, Quang Le Nam Bui, Thao Vy Thanh Do, Hung Hoa Lam, Tuyet-Mai Tran-Thuy, Long Quang Nguyen
Lotus seedpods (LSPs) are an abundant and underutilized agricultural residue discarded from lotus seed production. In this study, ZnCl2 and FeCl3 coactivation of LSP for one-pot preparation of magnetic activated carbon (MAC) was explored for the first time. X-ray diffraction (XRD) results showed that Fe3O4, Fe0, and ZnO crystals were formed in the LSP-derived carbon matrix. Notably, transmission electron
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-C3N4–Co3O4 Z-Scheme Junction with Green-Synthesized ZnO Photocatalyst for Efficient Degradation of Methylene Blue in Aqueous Solution Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-6-5 Mintesinot Tamiru Mengistu, Tadele Hunde Wondimu, Dinsefa Mensur Andoshe, Jung Yong Kim, Osman Ahmed Zelekew, Fekadu Gashaw Hone, Newaymedhin Aberra Tegene, Noto Susanto Gultom, Ho Won Jang
A simple wet chemical ultrasonic-assisted synthesis method was employed to prepare visible light-driven g-C3N4-ZnO-Co3O4 (GZC) heterojunction photocatalysts. X-ray diffraction (XRD), scanning electromicroscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), Brunauer–Emmett–Teller (BET), ultraviolet (UV), and electrochemical impedance spectroscopy (EIS) are used to characterize the prepared catalysts
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Synthesis, Characterization, Antimicrobial Properties, and Antioxidant Activities of Silver-N-Heterocyclic Carbene Complexes Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-5-26 Donia Bensalah, Nevin Gurbuz, Ismail Özdemir, Rafik Gatri, Lamjed Mansour, Naceur Hamdi
The emergence of antimicrobial resistance has become a major handicap in the fight against bacterial infections, prompting researchers to develop new, more effective, and multimodal alternatives. Silver and its complexes have long been used as antimicrobial agents in medicine because of their lack of resistance to silver, their low potency at low concentrations, and their low toxicity compared to most
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Bioinspired Synthesis of Zinc Molybdate Nanoparticles: An Efficient Material for Growth Inhibition of Escherichia coli, Staphylococcus aureus, and Dye Remediation Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-5-19 Sanjeev Machindra Reddy, Smita Badur Karmankar, Hayat Ali Alzahrani, Arti Hadap, Amjad Iqbal, Rawaf Alenazy, Mounir M. Salem-Bekhit, Bhawana Jain
Zinc molybdate nanoparticles with molybdate are synthesized through green method with different salt precursors using Moringa oleifera leaf extract. Those nanoparticles had structural, vibrational, and morphological properties, which were determined by X-ray diffraction (XRD). The crystalline size of synthesized zinc molybdate was 24.9 nm. Fourier transform infrared (FTIR) spectroscopy and field emission
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Nanoparticles: A Potential and Effective Method to Control Insect-Borne Diseases Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-5-11 Danyue Nie, Jiaqiao Li, Qinghua Xie, Lele Ai, Changqiang Zhu, Yifan Wu, Qiyuan Gui, Lingling Zhang, Weilong Tan
Insects act as vectors to carry a wide range of bacteria and viruses that can cause multiple vector-borne diseases in humans. Diseases such as dengue fever, epidemic encephalitis B, and epidemic typhus, which pose serious risks to humans, can be transmitted by insects. Due to the absence of effective vaccines for most arbovirus, insect control was the main strategy for vector-borne diseases control
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Metal Chelates of Sulfafurazole Azo Dye Derivative: Synthesis, Structure Affirmation, Antimicrobial, Antitumor, DNA Binding, and Molecular Docking Simulation Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-4-22 Hoda A. El-Ghamry, Rajaa O. Al-Ziyadi, Fatmah M. Alkhatib, Khadiga M. Takroni, Abdalla M. Khedr
A series of divalent and one trivalent metal chelates of the azo ligand resulting from coupling of sulfafurazole diazonium chloride with resorcinol have been designed and synthesized. Structure investigation of the isolated chelates have been achieved by applying spectroscopic and analytical tools which collaborated to assure the formation of the metal chelates in the molar ratios of 1L: 1M for Ni(II)
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Discovery of New Ligand with Quinoline Scaffold as Potent Allosteric Inhibitor of HIV-1 and Its Copper Complexes as a Powerful Catalyst for the Synthesis of Chiral Benzimidazole Derivatives, and in Silico Anti-HIV-1 Studies Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-4-21 Sabikeh G. Azimi, Ghodsieh Bagherzade, Mohammad Reza Saberi, Zeinab Amiri Tehranizadeh
In this paper, the novel Schiff base ligand containing quinoline moiety and its novel copper chelate complexes were successfully prepared. The catalytic activity of the final complex in the organic reaction such as synthesis of chiral benzimidazoles and anti-HIV-1 activity of Schiff base ligand and the products of this reaction were investigated. In addition, green chemistry reactions using microwaves
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Biosynthesis-Based Al2O3 Nanofiller from Cymbopogon citratus Leaf/Jute/Hemp/Epoxy-Based Hybrid Composites with Superior Mechanical Properties Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-4-20 L. Natrayan, Yenda Srinivasa Rao, Puthalapattu Reddy Prasad, Kul Bhaskar, Pravin P. Patil, Dereje Bayisa Abdeta
Metallic nanoparticles (NPs) manufactured by ecofriendly strategies have also received much interest because of their elastic scattering properties and performance in nanomaterials. Aluminium oxide nanomaterials stand out among nanomaterials due to their tremendous uses in ceramic products, fabrics, therapeutic agents, catalyst supports, sewage sludge, and biosensors. The current paper investigates
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Biosynthesis of Iron Oxide Nanoparticles Using Leaf Extract of Ruellia tuberosa: Mechanical and Dynamic Mechanical Behaviour Kevlar-Based Hybrid Epoxy Composites Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-4-20 L. Natrayan, Yenda Srinivasa Rao, Gayatri Vaidya, Sumanta Bhattacharya, S. Kaliappan, Pravin P. Patil, Prabhu Paramasivam
One of the more enticing, ecologically responsible, as well as safe and sustainable methodologies is eco-friendly nanomaterial synthesis. Vegetation materials will be used as reductants instead of toxic substances for synthesising nanoparticles. The current study used Ruellia tuberosa (RT) leaf extract digest to synthesise FeO nanomaterials, which were then characterised using XRD. Following that,
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5-Fluorouracil-Loaded PLGA Nanoparticles: Formulation, Physicochemical Characterisation, and In VitroAnti-Cancer Activity Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-4-17 Reem M. Gahtani, Ali Alqahtani, Taha Alqahtani, Saeed Ahmed Asiri, Jamal Moideen Muthu Mohamed, S. Venkatesa Prabhu, Endalew Yaze Muluneh
The major goal of this investigation was to prepare a drug delivery of polymeric nanoparticles (NPs) from 5-fluorouracil (FU) that could be delivered intravenously and improve the therapeutic index of the FU. In order to achieve this, interfacial deposition method was used to prepare FU entrapped poly-(lactic-co-glycolic acid) nanoparticles (FU-PLGA-NPs). The influence of various experimental settings
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Bioinorganic Nanoparticles for the Remediation of Environmental Pollution: Critical Appraisal and Potential Avenues Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-4-10 Md. Mominur Rahman, Limon Ahmed, Fazilatunnesa Anika, Anha Akter Riya, Sumaiya Khatun Kali, Abdur Rauf, Rohit Sharma
Nowadays, environmental pollution has become a critical issue for both developed and developing countries. Because of excessive industrialization, burning of fossil fuels, mining and exploration, extensive agricultural activities, and plastics, the environment is being contaminated rapidly through soil, air, and water. There are a variety of approaches for treating environmental toxins, but each has
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Optimization of Precious Metals Recovery from Electronic Waste by Chromobacterium violaceum Using Response Surface Methodology (RSM) Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-3-30 Wan Nur Fazlina Abdol Jani, Fatihah Suja’, Sharifah Iziuna Sayed Jamaludin, Nor Fadilah Mohamad, Noor Hidayu Abdul Rani
An effective recovery technology will be valuable in the future because the concentration of the precious metal contained in the source can be a key driver in recycling technology. This study aims to use response surface methodology (RSM) through Minitab software to discover the optimum oxygen level (mgL−1), e-waste pulp density (% w/v), and glycine concentration (mgL−1) for the maximum recovery of
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Grass-Shaped Zinc Oxide Nanoparticles Synthesized by the Sol-Gel Process and Their Antagonistic Properties towards the Biotrophic Parasite, Meloidogyne incognita Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-3-24 Amir Khan, Azmat Ali Khan, Mohd Jameel, Mohd Farhan Khan, Masudulla Khan, Arshad Khan, Faheem Ahmad, Mahboob Alam
The presence of Meloidogyne spp., also known as root-knot nematodes, presents a significant danger to global agricultural progress. Since chemical nematicides have high levels of toxicity, it is imperative to develop environmentally friendly methods to manage root-knot nematodes. Nanotechnology is now the most progressive way to attract researchers due to its innovative quality in combating plant diseases
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Modified Activated Carbon: A Supporting Material for Improving Clostridium beijerinckii TISTR1461 Immobilized Fermentation Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-3-23 Piyawat Chinwatpaiboon, Akarin Boonsombuti, Thanyalak Chaisuwan, Ancharida Savarajara, Apanee Luengnaruemitchai
This study aimed to investigate the effect of activated carbon (AC) as an immobilization material in acetone-butanol-ethanol fermentation. The AC surface was modified with different physical (orbital shaking and refluxing) and chemical (nitric acid, sodium hydroxide and, (3-aminopropyl)triethoxysilane (APTES)) treatments to enhance the biobutanol production by Clostridium beijerinckii TISTR1461. The
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Biomolecule Protective and Photocatalytic Potential of Cellulose Supported MoS2/GO Nanocomposite Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-3-9 Muhammad Pervaiz, Muti Ur Rehman, Faisal Ali, Umer Younas, Mika Sillanpaa, Rizwan Kausar, Asma A. Alothman, Mohamed Ouladsmane, Mohammad Abdul Mazid
In the current study, cellulose/MoS2/GO nanocomposite has been synthesized by a hydrothermal method. Reports published regarding efficiency of Mo and graphene oxide-based nanocomposites for environmental remediation motivated to synthesize cellulose supported MoS2/GO nanocomposite. Formation of nanocomposite was initially confirmed by UV-visible and FTIR spectroscopic techniques. Particle size and
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Enhanced Peroxidase-Like and Antibacterial Activity of Ir-CoatedPd-Pt Nanodendrites as Nanozyme Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-2-15 Jingfang Song, Jian He, Lin Yang, Weiguo Wang, Qinqin Bai, Wei Feng, Ranhui Li
To inhibit the growth of bacteria, the DA-PPI nanozyme with enhanced peroxidase-like activity was synthesized. The DA-PPI nanozyme was obtained by depositing high-affinity element iridium (Ir) on the surface of Pd-Pt dendritic structures. The morphology and composition of DA-PPI nanozyme were characterized using SEM, TEM, and XPS. The kinetic results showed that the DA-PPI nanozyme possessed a higher
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Assessment of Structural, Optical, and Antibacterial Properties of Green Sn(Fe : Ni)O2 Nanoparticles Synthesized Using Azadirachta indica Leaf Extract Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-2-7 Abeer S. Aloufi
Metal oxide nanoparticles have attained notable recognition due to their interesting physicochemical properties. Although these nanoparticles can be synthesized using a variety of approaches, the biological method involving plant extracts is preferred since it provides a simple, uncomplicated, ecologically friendly, efficient, rapid, and economical way for synthesis. In this study, the Azadirachta
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Hybrid MWCNT and TiO2 Nanoparticle-Suspended Waste Tyre Oil Biodiesel for CI Engines Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-2-3 T. Sathish, V. Mohanavel, T. Raja, M. Ravichandran, P. Murugan, S. Suresh Kumar, Sultan Alqahtani, Sultan Alshehery, J. Isaac Joshua Ramesh Lalvani
Nowadays, scarcity arises in almost all our basic needs, including water, fuel, and food. Recycling used and scrapped things for a valuable commodity is highly appreciable for compensating for the globally fast-growing demand. This paper aims to investigate waste tyre oil for preparing biodiesel for CI engines by enhancing their performance with hybrid nanoparticles for preparing nanofuel and hybrid
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Bioinorganic Preparation of Hydroxyapatite and Rare Earth Substituted Hydroxyapatite for Biomaterials Applications Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-1-25 Suha Q. Al-Shahrabalee, Hussein Alaa Jaber
Rare Earth elements in the lanthanide series are regarded as one of the finest options for the cationic substitution of calcium ions in hydroxyapatite (HA) because of their favorable impact on the biological characteristics of substituted HA. Neodymium and cerium were used to substitute 5% of calcium ions in HA, prepared via the wet precipitation method. Characterization tests for pure and substituted
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Plant Extract Based on Deep Eutectic Solvent-Mediated Biosynthesis of Silver Nanoparticles: Cytotoxicity and Antibacterial Effects Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-1-14 Victoria I. Vorobyova
Deep eutectic solvent DES-based grape pomace extracts (GPE) were used to synthesize silver nanoparticles (AgNPs) for the first time. This paper presents a synthesis of AgNPs by a novel method with GPE obtained by an eco-friendly “green” solvent, namely, betaine-lactic acid and proline-lactic acid DESs. Compared with the water-based GPE, the DES-based grape pomace extracts contain lower reducing powers
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Moxifloxacin Metal Complexes: Synthesis, Characterisation, Antimicrobial and Antidiabetic Activities with Docking Studies Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2023-1-3 Sajjad Ali, Huaiji Zheng, Asma Zaidi, Farhan Ahmed Khan, Syed Majid Bukhari, Muhammad Riaz, Muhammad Mumtaz Khan, Shehla Sammi, Inham u-llah, Ammad Amin, Muhammad Jahangir
Six new metal complexes of Fe(III), Cu(II), and Hg(II) were synthesised, i.e., three (2, 4, and 5) with moxifloxacin (mono-ligand) and the other three (1, 3 and 6) with moxifloxacin and hydrazine (biligand). These were characterised through UV-Vis, FT-IR, elemental analysis (CHN), atomic absorption spectroscopy, TGA, scanning electron microscopy (SEM), and powder XRD studies. Further, all of these
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The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-12-30 Elisabetta Gabano, Ilaria Zanellato, Giulia Pinton, Laura Moro, Mauro Ravera, Domenico Osella
The biological behavior of the axially unsymmetric antitumor prodrug (OC-6-44)-acetatodiamminedichloridohydroxidoplatinum(IV), 2, was deeply investigated and compared with that of analogous symmetric Pt(IV) complexes, namely, dihydroxido 1 and diacetato 3, which have a similar structure. The complexes were tested on a panel of human tumor cell lines. Complex 2 showed an anomalous higher cytotoxicity
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Glutaraldehyde-Polymerized Hemerythrin: Evaluation of Performance as an Oxygen Carrier in Hemorrhage Models Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-12-30 Anca D. Stoica, Vlad-Al. Toma, Ioana Roman, Bogdan Sevastre, Florina Scurtu, Radu Silaghi-Dumitrescu
Hemoglobin-based oxygen carriers (HBOCs) have been proposed and tested for several decades for the treatment of hemorrhage. We have previously proposed replacing hemoglobin (Hb) in HBOC with the oxygen-carrying protein hemerythrin (Hr), from marine worms, showing that Hr-based derivatives can perform at least as well or even better than Hb-based HBOC in a range of in vitro assays involving oxidative
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Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-12-16 Simon Ngigi Mbugua
Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have
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Antimicrobial Effects of Gum Arabic-Silver Nanoparticles against Oral Pathogens Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-12-13 Omnia Ahmed, Nicole R. S. Sibuyi, Adewale O. Fadaka, Abram M. Madiehe, Ernest Maboza, Annette Olivier, Mervin Meyer, Greta Geerts
Dental caries is considered one of the most prevalent oral diseases worldwide, with a high rate of morbidity among populations. It is a chronic infectious disease with a multifactorial etiology that leads to the destruction of the dental tissues. Due to their antimicrobial, anti-inflammatory, antifungal, and antioxidant properties; silver nanoparticles (AgNPs) are incorporated in dental products to
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Comprehensive Assessment of Biomolecular Interactions of Morpholine-Based Mixed Ligand Cu(II) and Zn(II) Complexes of 2,2′-Bipyridine as Potential Anticancer and SARS-CoV-2 Agents: A Synergistic Experimental and Structure-Based Virtual Screening Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-12-12 Karunganathan Sakthikumar, Rui Werner Maçedo Krause, Bienfait Kabuyaya Isamura
A new class of pharmacologically active mixed-ligand complexes (1a-2a) [MII(L)2 (bpy)], where L = 2-(4-morpholinobenzylideneamino)phenol), bpy = 2,2′-bipyridine, MII = Cu (1a), and Zn (2a), were assigned an octahedral geometry by analytical and spectral measurements. Gel electrophoresis showed that complex (1a) demonstrated the complete DNA cleavage mediated by H2O2. The overall DNA-binding constants
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Deferiprone−Resveratrol Hybrid, an Iron-Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent in Plasmodium berghei-Infected Mice Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-11-24 Hataichanok Chuljerm, Supawadee Maneekesorn, Chuchard Punsawad, Voravuth Somsak, Yongmin Ma, Jetsada Ruangsuriya, Somdet Srichairatanakool, Pimpisid Koonyosying
Free heme in plasma acts as a prooxidant; thus, it is bound to hemopexin and eliminated by the liver. High iron content in the liver can support Plasmodium growth and cause oxidative liver injury. Inversely, the withholding of excessive iron can inhibit this growth and protect the liver against malaria infection. This study examined the effects of a deferiprone-resveratrol (DFP-RVT) hybrid on malaria
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Evaluation of Behavior of 13X Zeolite Modified with Transition Metals for Catalytic Applications Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-10-26 Elena. David
This work was intended to develop catalysts based on 13X zeolite modified with transition metals for catalytic applications. In this regard, 13X zeolite was modified by loading of transition metals such as Fe, Co, Cu and various types of catalysts such as Fe-, Co-, Cu-, Fe-Co-, Fe-Cu-, and Co-Cu/13X zeolite were obtained. To prepare these catalysts, the wet impregnation method and metallic precursors
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Marine Algae Extract (Grateloupia Sparsa) for the Green Synthesis of Co3O4NPs: Antioxidant, Antibacterial, Anticancer, and Hemolytic Activities Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-10-20 Amira K. Hajri, Marzough A. Albalawi, Ifat Alsharif, Bassem Jamoussi
The aqueous extract of red algae was used for bio-inspired manufacturing of cobalt oxide nanoparticles (Co3O4NPs) and for antioxidant, antibacterial, hemolytic potency, and anticancer activity. Typical, characterization techniques include UV-Vis, SEM, EDAX, TEM, FTIR, XRD, and TGA. Using an X-ray diffraction assay, the size of the Co3O4NPs crystal was determined to range from 23.2 to 11.8 nm. Based
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Molecular Docking and Green Synthesis of Bioinorganic TiO2 Nanoparticles against E.coli and S.aureus Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-10-15 Rasha Hamed Al-Serwi, Mohamed El-Sherbiny, T.V. Ajay Kumar, Abdulmalik Abdulghani Qasim, Thekra Khattar, Yahia Alghazwani, Ali Alqahtani, Venkatesan Krishnaraju, Jamal Moideen Muthu Mohamed, Venkatesa Prabhu Sundramurthy
This study used a simple solution evaporation approach to make a bioinorganic titanium dioxide (Bi-TiO2) photocatalyst for dye contaminant degradation. A variety of techniques, including X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM) coupled with energy dispersive X-ray analysis (EDAX), and differential reflectance spectroscopy, had been
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Facile Fabrication of CuO Nanoparticles Embedded in N-Doped Carbon Nanostructure for Electrochemical Sensing of Dopamine Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-10-14 Nebras Sobahi, Mohd Imran, Mohammad Ehtisham Khan, Akbar Mohammad, Md. Mottahir Alam, Taeho Yoon, Ibrahim M. Mehedi, Mohammad A. Hussain, Mohammed J. Abdulaal, Ahmad A. Jiman
In the present study, a highly selective and sensitive electrochemical sensing platform for the detection of dopamine was developed with CuO nanoparticles embedded in N-doped carbon nanostructure (CuO@NDC). The successfully fabricated nanostructures were characterized by standard instrumentation techniques. The fabricated CuO@NDC nanostructures were used for the development of dopamine electrochemical
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The Adsorption Potential of Cr from Water by ZnO Nanoparticles Synthesized by Azolla pinnata Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-10-11 Ou Wenjie, Waqas Ahmed, Fu Xiuxian, Wang Lu, Li Jiannan, Yang Jie, Rana Muhammad Ammar Asghar, Mohsin Mahmood, Juha M. Alatalo, Muhammad Imtiaz, Weidong Li, Sajid Mehmood
Aqueous solutions containing toxic elements (TEs) (such as hexavalent chromium (Cr (VI)) can be toxic to humans even at trace levels. Thus, removing TEs from the aqueous environment is essential for the protection of biodiversity, hydrosphere ecosystems, and humans. For plant fabrication of zinc oxide nanoparticles (PF-ZnONPs), Azolla pinnata plants were used, and X-ray diffraction (XRD), energy dispersive
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Research on the Purification of Environmental Pollution by Biomaterials and Its Treatment Methods in the Development of Rural Cultural and Creative Industries Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-10-4 Ting Fan, Tianyou Fu, Qun Xu, Gazmir Gjoni
Since our country put forward the rural revitalization strategy, we have attached great importance to the construction and development of urban and rural areas. In recent years, we have continuously enhanced the driving force of development and further promoted rural reform. However, in the construction of rural cultural industry, how to purify environmental pollution is a key and difficult point.
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Silver Nanoparticles Stabilized by Poly (Vinyl Pyrrolidone) with Potential Anticancer Activity towards Prostate Cancer Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-9-30 Ahmed A. H. Abdellatif, Ahmed Abdelfattah, Abdellatif Bouazzaoui, Shaaban K. Osman, Issa Saad Al-Moraya, Abdulaziz M. Saleh Showail, Mansour Alsharidah, Ashraf Aboelela, Osamah Al Rugaie, Tarek M. Faris, Hesham M. Tawfeek
Tumor necrosis factor (TNF-α) and inflammatory cytokine (IL-6) play a vital role in various cellular incidents such as the proliferation and death of cells during carcinogenesis. Hence, regulation of these biomarkers could be a promising tool for controlling tumor progression using nanoformulations. Silver nanoparticles-poly (vinyl pyrrolidone) (AgNPs-PVP) were prepared using the reduction of silver
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Study on Nano Drug Particles in the Diagnosis and Treatment of Alzheimer’s Disease in the Elderly Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-9-29 ChangQing Li, Yu Xiang, Yunqian Wang, Ping Li
Objective. To study the clinical effect of nano drug particles in the diagnosis and treatment of Alzheimer’s disease in the elderly, we promote the research on the treatment of Alzheimer’s disease and provide basis. Methods. 80 patients with Alzheimer’s disease treated in our hospital from April 2021 to April 2022 were selected as the research objects and were divided into the reference group and the
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Structural, Optical, Antibacterial, and Anticancer Properties of Cerium Oxide Nanoparticles Prepared by Green Synthesis Using Morinda citrifolia Leaves Extract Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-9-28 Abozer Y. Elderdery, Badr Alzahrani, Abdulrahim A. Alabdulsalam, Siddiqa M. A. Hamza, Ahmed M. E. Elkhalifa, Abdulaziz H. Alhamidi, Fehaid Alanazi, A. Mohamedain, Suresh Kumar Subbiah, Pooi Ling Mok
Currently, new advancements in the area of nanotechnology opened up new prospects in the field of medicine that could provide us with a solution for numerous medical complications. Although a several varieties of nanoparticles is being explored to be used as nanomedicines, cerium oxide nanoparticles (CeO2 NPs) are the most attractive due to their biocompatibility and their switchable oxidation state
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Synthesis of Zinc Oxide (ZnO)-Titanium Dioxide (TiO2)-Chitosan-Farnesol Nanocomposites and Assessment of Their Anticancer Potential in Human Leukemic MOLT-4 Cell Line Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-9-28 Abozer Y. Elderdery, Badr Alzahrani, Siddiqa M. A. Hamza, Gomaa Mostafa-Hedeab, Pooi Ling Mok, Suresh Kumar Subbiah
Leukemia is the most prevalent cancer in children and one of the most common and deadly cancers that affect adults. Several metal oxide nanoparticles, biopolymers, and phytochemicals have been discovered to target cancer cells selectively while inflicting low to no damage to healthy cells. Among the existing nanoparticle synthesis methodologies, biologically synthesized nanoparticles using phytochemicals
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Synthesis, Characterization, and Antiproliferative Effect of CuO-TiO2-Chitosan-Amygdalin Nanocomposites in Human Leukemic MOLT4 Cells Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-9-26 Abozer Y. Elderdery, Badr Alzahrani, Siddiqa M. A. Hamza, Gomaa Mostafa-Hedeab, Pooi Ling Mok, Suresh Kumar Subbiah
The main aim of this study was to synthesize copper oxide- (CuO-) titanium oxide- (TiO2-) chitosan-amygdalin nanocomposites (CTCANc) and to characterize them physically and biologically (antimicrobial and anticancer activity using MOLT4 blood cancer cell line) to endorse their useful applications as potential drug candidates in anticancer avenues. CuO-TiO2-chitosan-amygdalin nanocomposites were synthesized
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Fungal- and Algal-Derived Synthesis of Various Nanoparticles and Their Applications Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-9-26 Anugrah Michael, Aniket Singh, Arpita Roy, Md. Rabiul Islam
Nanoparticles synthesis through biological mediated methods with a particular focus on the processes mediated by fungi and algae is discussed, which systematically reviews nanoparticle characterization, composition, synthesis methods, and, lastly but not least, the applications of NPs across five different categories to provide a reference for future research. Most traditional methods to generate nanoparticles
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Research on Microseismic Source Location Method Based on Waveform Characteristics Monitored by Nanomaterial Sensor under the Background of Metal Oxide Polluted Environment Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-9-24 Shuai Wang, Zhaoxin Hu, Shasha Lu
In recent years, the monitoring range of source location technology has developed from being one-dimensional and two-dimensional to being three-dimensional. However, due to the complexity and nonuniformity of the seismic wave propagation medium and the uncertainty of the propagation law, there will be large errors in the source location results. Therefore, the analysis of vibration signal has become
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Cytotoxicity and Genotoxicity of Biogenic Silver Nanoparticles in A549 and BEAS-2B Cell Lines Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-9-23 Musthahimah Muhamad, Nurhidayah Ab.Rahim, Wan Adnan Wan Omar, Nik Nur Syazni Nik Mohamed Kamal
Introduction. Biogenic silver nanoparticles (AgNPs-GA) were successfully synthesised using Garcinia atroviridis leaf extract as a reducing agent, which has ethnopharmacological claims against various diseases including cancer. Aim of the Study. Aim of the study is to discover whether AgNPs-GA has cytotoxic and genotoxic effects on cancerous (A549) and noncancerous (BEAS-2B) human lung cells. Materials
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Development and Characterization of Carbon-Based Adsorbents Derived from Agricultural Wastes and Their Effectiveness in Adsorption of Heavy Metals in Waste Water Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-9-23 L. Natrayan, S. Kaliappan, C. Naga Dheeraj Kumar Reddy, M. Karthick, N.S. Sivakumar, Pravin P Patil, S. Sekar, Subash Thanappan
The current work focuses on peanut shells and agricultural wastes richly in many nations subjected to pyrolysis treatment at various temperatures in the range of 500–800°C to determine the feasible physiochemical characteristics of the biochar. The biochars with the high surface area were employed to adsorb Pb2+ (lead) ions, the heaviest pollutants in the water bodies. The raw material, biochar, and
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Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging. Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-09-13 Charini Maladeniya,Taniya Darshani,Sameera R Samarakoon,Frank R Fronczek,W M C Sameera,Inoka C Perera,Theshini Perera
Platinum-based compounds are actively used in clinical trials as anticancer agents. In this study, two novel platinum complexes, (C1 = [PtCl2(N(SO2quin)dpa)], C2 = [PtCl2(N(SO2azobenz)dpa)]) containing quinoline and azobenzene appended dipicolylamine sulfonamide ligands were synthesized in good yield. The singlet attributable to methylene CH2 protons of the ligands of C1 and C2 appears as two doublets
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Cytotoxicity and Antibacterial Activity of Mineral Trioxide Aggregate Cement with Radiopacity Introduced by ZrO2 Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-09-06 Lidia Ciołek, Zbigniew Jaegermann, Ewa Zaczyńska, Anna Czarny, Monika Biernat, Arkadiusz Gąsiński, Agnieszka Jastrzębska, Michał Gloc, Andrzej Olszyna
The article presents the results of in vitro studies on cytotoxicity and antibacterial activity of new MTA-type cements, developed on the basis of the sintered tricalcium silicate enriched with ZnO, along with an agent introducing the radiopacity in the form of ZrO2. The new materials have been developed to ensure that their physical and chemical properties are suited for endodontic applications. The
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A Study on Glycyrrhiza glabra-Fortified Bread: Predicted Glycemic Index and Bioactive Component Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-08-30 M. Prabhahar, Gomathi K, Prakash S, Sendilvelan S, Saravana Kumar M, Jijina GO, Edwin Geo Varuvel, Haiter Lenin A
Bread is one of the highest-selling food products throughout the world. Lots of demand arose from the bread producers by the consumers to convert the traditional bread into functional food. In this study, normal bread was converted to functional herbal bread by infusing it with extracts of Glycyrrhiza glabra. The functional components of the Glycyrrhiza glabra were analyzed by liquid chromatography-mass
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Physicochemical Properties and Antibacterial Activity of Gellan Gum Incorporating Zinc Oxide/Carbon Nanotubes Bionanocomposite Film for Wound Healing Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-08-28 Jichao Liu, Nur Arifah Ismail, Mahani Yusoff, Mohd Hasmizam Razali
Wound healing dressing based on a natural polymer of gellan gum incorporating zinc oxide nanoparticles and multiwall carbon nanotubes (GG/ZnONP + MWCNT) bionanocomposite film was fabricated via the solution casting method. The physicochemical properties of the film were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM). Moreover,
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Chronological Age Estimation of Male Occipital Bone Based on FTIR and Raman Microspectroscopy Bioinorg. Chem. Appl. (IF 3.8) Pub Date : 2022-08-26 Kai Yu, Hongli Xiong, Xin Wei, Hao Wu, Bo Zhang, Gongji Wang, Xiaorong Yang, Zhenyuan Wang
Age-related changes in bone tissue have always been an important part of bone research, and age estimation is also of great significance in forensic work. In our study, FTIR and Raman microspectroscopy were combined to explore the structural and chronological age-related changes in the occipital bones of 40 male donors. The FTIR micro-ATR mode not only achieves the comparison of FTIR and Raman efficiency