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Two Types of Survival Curves of Different Lines of Progeric Mice Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Svyatoslav S. Sokolov, Fedor F. Severin
Abstract For most of their lifespan, the probability of death for many animal species increases with age. Gompertz law states that this increase is exponential. In this work, we have compared previously published data on the survival kinetics of different lines of progeric mice. Visual analysis showed that in six lines of these rapidly aging mutants, the probability of death did not strictly depend
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Biological Clocks: Why We Need Them, Why We Cannot Trust Them, How They Might Be Improved Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Josh Mitteldorf
Abstract Late in life, the body is at war with itself. There is a program of self-destruction (phenoptosis) implemented via epigenetic and other changes. I refer to these as type (1) epigenetic changes. But the body retains a deep instinct for survival, and other epigenetic changes unfold in response to a perception of accumulated damage (type (2)). In the past decade, epigenetic clocks have promised
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Safari with an Electron Gun: Visualization of Protein and Membrane Interactions in Mitochondria in Natural Environment Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Semen V. Nesterov, Konstantin S. Plokhikh, Yuriy M. Chesnokov, Denis A. Mustafin, Tatyana N. Goleva, Anton G. Rogov, Raif G. Vasilov, Lev S. Yaguzhinsky
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Retinoprotective Effect of SkQ1, Visomitin Eye Drops, Is Associated with Suppression of P38 MAPK and ERK1/2 Signaling Pathways Activity Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Natalia A. Muraleva, Anna A. Zhdankina, Anzhella Zh. Fursova, Nataliya G. Kolosova
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Relationship of Cytotoxic and Antimicrobial Effects of Triphenylphosphonium Conjugates with Various Quinone Derivatives Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Pavel A. Nazarov, Lyudmila A. Zinovkina, Anna A. Brezgunova, Konstantin G. Lyamzaev, Andrei V. Golovin, Marina V. Karakozova, Elena A. Kotova, Egor Yu. Plotnikov, Roman A. Zinovkin, Maxim V. Skulachev, Yuri N. Antonenko
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Evolution of Longevity in Tetrapods: Safety Is More Important than Metabolism Level Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Gregory A. Shilovsky, Tatyana S. Putyatina, Alexander V. Markov
Abstract Various environmental morphological and behavioral factors can determine the longevity of representatives of various taxa. Long-lived species develop systems aimed at increasing organism stability, defense, and, ultimately, lifespan. Long-lived species to a different extent manifest the factors favoring longevity (gerontological success), such as body size, slow metabolism, activity of body’s
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Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Irina G. Shabalina, Daniel Edgar, Natalia Gibanova, Anastasia V. Kalinovich, Natasa Petrovic, Mikhail Yu. Vyssokikh, Barbara Cannon, Jan Nedergaard
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Mitocentricity Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Dmitry B. Zorov, Polina A. Abramicheva, Nadezda V. Andrianova, Valentina A. Babenko, Ljubava D. Zorova, Savva D. Zorov, Irina B. Pevzner, Vasily A. Popkov, Dmitry S. Semenovich, Elmira I. Yakupova, Denis N. Silachev, Egor Y. Plotnikov, Gennady T. Sukhikh
Abstract Worldwide, interest in mitochondria is constantly growing, as evidenced by scientific statistics, and studies of the functioning of these organelles are becoming more prevalent than studies of other cellular structures. In this analytical review, mitochondria are conditionally placed in a certain cellular center, which is responsible for both energy production and other non-energetic functions
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Developing Peripheral Biochemical Biomarkers of Brain Disorders: Insights from Zebrafish Models Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Nikita P. Ilyin, Elena V. Petersen, Tatyana O. Kolesnikova, Konstantin A. Demin, Sergey L. Khatsko, Kirill V. Apuhtin, Allan V. Kalueff
Abstract High prevalence of human brain disorders necessitates development of the reliable peripheral biomarkers as diagnostic and disease-monitoring tools. In addition to clinical studies, animal models markedly advance studying of non-brain abnormalities associated with brain pathogenesis. The zebrafish (Danio rerio) is becoming increasingly popular as an animal model organism in translational neuroscience
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Exploring Patterns of Human Mortality and Aging: A Reliability Theory Viewpoint Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Leonid A. Gavrilov, Natalia S. Gavrilova
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Age-Dependent Changes in the Production of Mitochondrial Reactive Oxygen Species in Human Skeletal Muscle Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Mikhail Yu. Vyssokikh, Maksim A. Vigovskiy, Vladislav V. Philippov, Yakov R. Boroday, Mariya V. Marey, Olga A. Grigorieva, Tatiana F. Vepkhvadze, Nadezhda S. Kurochkina, Ludmila A. Manukhova, Anastasiya Yu. Efimenko, Daniil V. Popov, Vladimir P. Skulachev
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A Redox-Regulated, Heterodimeric NADH:cinnamate Reductase in Vibrio ruber Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Yulia V. Bertsova, Marina V. Serebryakova, Victor A. Anashkin, Alexander A. Baykov, Alexander V. Bogachev
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Organ Frame Elements or Free Intercellular Gel-Like Matrix as Necessary Conditions for Building Organ Structures during Regeneration Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-20 Vasily N. Manskikh
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Reactive Halogen Species: Role in Living Systems and Current Research Approaches Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Yuliya V. Khramova, Veronika A. Katrukha, Victoria V. Chebanenko, Alexander I. Kostyuk, Nikolay P. Gorbunov, Oleg M. Panasenko, Alexey V. Sokolov, Dmitry S. Bilan
Abstract Reactive halogen species (RHS) are highly reactive compounds that are normally required for regulation of immune response, inflammatory reactions, enzyme function, etc. At the same time, hyperproduction of highly reactive compounds leads to the development of various socially significant diseases – asthma, pulmonary hypertension, oncological and neurodegenerative diseases, retinopathy, and
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Post-Translational Oxidative Modifications of Hemostasis Proteins: Structure, Function, and Regulation Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Mark A. Rosenfeld, Lyubov V. Yurina, Elizaveta S. Gavrilina, Alexandra D. Vasilyeva
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Multicomponent DNAzyme Nanomachines: Structure, Applications, and Prospects Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Daria D. Nedorezova, Maria S. Rubel, Aleksandr A. Rubel
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Formation of Supplementary Metal-Binding Centers in Proteins under Stress Conditions Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Olga V. Kosmachevskaya, Natalia N. Novikova, Sergey N. Yakunin, Alexey F. Topunov
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Fenton Reaction in vivo and in vitro. Possibilities and Limitations Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Konstantin O. Muranov
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Animal Models of FUS-Proteinopathy: A Systematic Review Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Alexander Rezvykh, Daniil Shteinberg, Evgeny Bronovitsky, Aleksey Ustyugov, Sergei Funikov
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G-Quadruplexes as Sensors of Intracellular Na+/K+ Ratio: Potential Role in Regulation of Transcription and Translation Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Olga D. Lopina, Svetlana V. Sidorenko, Dmitry A. Fedorov, Elizaveta A. Klimanova
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Biomolecular Condensates: Structure, Functions, Methods of Research Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Natalia A. Gorsheneva, Julia V. Sopova, Vladimir V. Azarov, Anastasia V. Grizel, Aleksandr A. Rubel
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The Role of Vitamin K in the Development of Neurodegenerative Diseases Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Anna I. Diachenko, Igor A. Rodin, Tatiana N. Krasnova, Oleg I. Klychnikov, Lidia N. Nefedova
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Synthetic Biology Approaches to Posttranslational Regulation in Plants Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Inna A. Abdeeva, Yulia S. Panina, Liliya G. Maloshenok
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Electroanalysis in Pharmacogenomic Studies: Mechanisms of Drug Interaction with DNA Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Victoria V. Shumyantseva, Veronica V. Pronina, Tatiana V. Bulko, Lyubov E. Agafonova
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Free Radical Lipid Peroxidation Induced by Reactive Halogen Species Biochemistry Moscow (IF 2.8) Pub Date : 2024-03-08 Oleg M. Panasenko, Yury A. Vladimirov, Valery I. Sergienko
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Impairment of Assembly of the Vimentin Intermediate Filaments Leads to Suppression of Formation and Maturation of Focal Contacts and Alteration of the Type of Cellular Protrusions Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Anna O. Zholudeva, Nikolay S. Potapov, Ekaterina A. Kozlova, Maria E. Lomakina, Antonina Y. Alexandrova
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Serum Glycome as a Diagnostic and Prognostic Factor in Gestational Diabetes Mellitus Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Ognjen Radojičić, Lucia Pažitná, Zorana Dobrijević, Paras Kundalia, Kristina Kianičková, Jaroslav Katrlík, Vesna Mandić Marković, Željko Miković, Olgica Nedić, Dragana Robajac
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Natural Activators of Autophagy Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Julia A. Pavlova, Ekaterina A. Guseva, Olga A. Dontsova, Petr V. Sergiev
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Synthetic Activators of Autophagy Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Ekaterina A. Guseva, Julia A. Pavlova, Olga A. Dontsova, Petr V. Sergiev
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The Functions of N6-Methyladenosine in Nuclear RNAs Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Nadezhda A. Zhigalova, Katerina Yu. Oleynikova, Alexey S. Ruzov, Alexander S. Ermakov
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N-Terminal Fragment of Cardiac Myosin Binding Protein C Modulates Cooperative Mechanisms of Thin Filament Activation in Atria and Ventricles Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Anastasia M. Kochurova, Evgenia A. Beldiia, Victoria V. Nefedova, Natalia S. Ryabkova, Daria S. Yampolskaya, Alexander M. Matyushenko, Sergey Y. Bershitsky, Galina V. Kopylova, Daniil V. Shchepkin
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Influence of Nucleotide Context on Non-Specific Amplification of DNA with Bst exo– DNA Polymerase Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Ravil R. Garafutdinov, Olga Yu. Kupova, Assol R. Sakhabutdinova
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Synthesis and Biological Properties of Polyphenol-Containing Linear and Dendrimeric Cationic Peptides Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Artem A. Shatilov, Sergey M. Andreev, Anastasiya V. Shatilova, Evgeny A. Turetskiy, Renata A. Kurmasheva, Marina O. Babikhina, Larisa V. Saprygina, Nadezhda N. Shershakova, Dar’ya K. Bolyakina, Valeriy V. Smirnov, Igor P. Shilovsky, Musa R. Khaitov
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Pathogenetic Significance of Long Non-Coding RNAs in the Development of Thoracic and Abdominal Aortic Aneurysms Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Aksana N. Kucher, Iuliia A. Koroleva, Maria S. Nazarenko
Abstract Aortic aneurysm (AA) is a life-threatening condition with a high prevalence and risk of severe complications. The aim of this review was to summarize the data on the role of long non-coding RNAs (lncRNAs) in the development of AAs of various location. Within less than a decade of studies on the role of lncRNAs in AA, using experimental and bioinformatic approaches, scientists have obtained
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Immunology of SARS-CoV-2 Infection Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-14 Aida G. Gabdoulkhakova, Rimma N. Mingaleeva, Albina M. Romozanova, Aisylu R. Sagdeeva, Yulia V. Filina, Albert A. Rizvanov, Regina R. Miftakhova
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Calculating Aging: Analysis of Survival Curves in the Norm and Pathology, Fluctuations in Mortality Dynamics, Characteristics of Lifespan Distribution, and Indicators of Lifespan Variation Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-01
Abstract The article describes the history of studies of survival data carried out at the Research Institute of Physico-Chemical Biology under the leadership of Academician V. P. Skulachev from 1970s until present, with special emphasis on the last decade. The use of accelerated failure time (AFT) model and analysis of coefficient of variation of lifespan (CVLS) in addition to the Gompertz methods
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AgeMeta: Quantitative Gene Expression Database of Mammalian Aging Biochemistry Moscow (IF 2.8) Pub Date : 2024-02-01
Abstract AgeMeta is a database that provides systemic and quantitative description of mammalian aging at the level of gene expression. It encompasses transcriptomic changes with age across various tissues of humans, mice, and rats, based on a comprehensive meta-analysis of 122 publicly available gene expression datasets from 26 studies. AgeMeta provides an intuitive visual interface for quantification
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Direct Determination of the Structure of Single Biopolymer Molecules Using Nanopore Sequencing Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract This review highlights operational principles, features, and modern aspects of the development of third-generation sequencing technology of biopolymers focusing on the nucleic acids analysis, namely the nanopore sequencing system. Basics of the method and technical solutions used for its realization are considered, from the first works showing the possibility of creation of these systems to
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Tumor Organoids: The Era of Personalized Medicine Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract The strategies of future medicine are aimed to modernize and integrate quality approaches including early molecular-genetic profiling, identification of new therapeutic targets and adapting design for clinical trials, personalized drug screening (PDS) to help predict and individualize patient treatment regimens. In the past decade, organoid models have emerged as an innovative in vitro platform
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Leaf Extract from European Olive (Olea europaea L.) Post-Transcriptionally Suppresses the Epithelial-Mesenchymal Transition and Sensitizes Gastric Cancer Cells to Chemotherapy Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract The overall survival of patients with the advanced and recurrent gastric cancer (GC) remains unfavorable. In particular, this is due to cancer spreading and resistance to chemotherapy associated with the epithelial-mesenchymal transition (EMT) of tumor cells. EMT can be identified by the transcriptome profiling of GC for EMT markers. Indeed, analysis of the TCGA and GTEx databases (n = 408)
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Genomic Imprinting and Random Monoallelic Expression Biochemistry Moscow (IF 2.8) Pub Date : 2024-01-01
Abstract The review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the parental origin of the allele, and random monoallelic transcription. Data on the regulation of gene activity in the imprinted regions are summarized with a particular focus on the areas controlling imprinting and factors influencing the variability of the imprintome
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Phenoptosis and the Various Types of Natural Selection Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Giacinto Libertini
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Opposite Effects of CRABP1 and CRABP2 Homologs on Proliferation of Breast Cancer Cells and Their Sensitivity to Retinoic Acid Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Adel D. Enikeev, Pavel M. Abramov, Danila S. Elkin, Andrey V. Komelkov, Anastasiya A. Beliaeva, Darya M. Silantieva, Elena M. Tchevkina
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Serotonin Receptors as a Potential Target in the Treatment of Alzheimer’s Disease Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Dmitrii V. Eremin, Elena M. Kondaurova, Aleksander Ya. Rodnyy, Camilla A. Molobekova, Dmitrii A. Kudlay, Vladimir S. Naumenko
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Changes in the Glutamate/GABA System in the Hippocampus of Rats with Age and during Alzheimer’s Disease Signs Development Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Alena O. Burnyasheva, Natalia A. Stefanova, Nataliya G. Kolosova, Darya V. Telegina
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Dicarbonyl-Modified Low-Density Lipoproteins Are Key Inducers of LOX-1 and NOX1 Gene Expression in the Cultured Human Umbilical Vein Endotheliocytes Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Vadim Z. Lankin, Mars G. Sharapov, Alla K. Tikhaze, Ruslan G. Goncharov, Olga A. Antonova, Galina G. Konovalova, Vladimir I. Novoselov
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Impact of Lipid Matrix Composition on Activity of Membranotropic Enzymes Galactonolactone Oxidase from Trypanosoma cruzi and L-Galactono-1,4-Lactone Dehydrogenase from Arabidopsis thaliana in the System of Reverse Micelles Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Andrey A. Chudin, Elena V. Kudryashova
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Effect of Dexamethasone on Adhesion of Human Neutrophils and Concomitant Secretion Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Svetlana I. Galkina, Ekaterina A. Golenkina, Natalia V. Fedorova, Alexander L. Ksenofontov, Marina V. Serebryakova, Vladimir I. Stadnichuk, Ludmila A. Baratova, Galina F. Sud’ina
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The Role of Ubiquitin–Proteasome System in the Biology of Stem Cells Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Alexander V. Burov, Andrey A. Rodin, Vadim L. Karpov, Alexey V. Morozov
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A New Mouse Strain with a Mutation in the NFE2L2 (NRF2) Gene Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Evgeniy S. Egorov, Natalia D. Kondratenko, Olga A. Averina, Oleg A. Permyakov, Maria A. Emelyanova, Anastasia S. Prikhodko, Ludmila A. Zinovkina, Petr V. Sergiev, Roman A. Zinovkin
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Topology of Ubiquitin Chains in the Chromatosomal Environment of the E3 Ubiquitin Ligase RNF168 Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Anna A. Kudriaeva, Lyudmila A. Yakubova, George A. Saratov, Vasiliy I. Vladimirov, Valeriy M. Lipkin, Alexey A. Belogurov
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Nocistatin and Products of Its Proteolysis Are Dual Modulators of Type 3 Acid-Sensing Ion Channels (ASIC3) with Algesic and Analgesic Properties Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Dmitry I. Osmakov, Nadezhda V. Tarasova, Andrey A. Nedorubov, Victor A. Palikov, Yulia A. Palikova, Igor A. Dyachenko, Yaroslav A. Andreev, Sergey A. Kozlov
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Low-Frequency Oscillations of Bacteriochlorophyll Oligomers in Chlorosomes of Photosynthetic Green Bacteria Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Andrei G. Yakovlev, Alexandra S. Taisova, Zoya G. Fetisova
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The Role of Aurora B Kinase in Normal and Cancer Cells Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Ekaterina Titova, Galina Shagieva, Vera Dugina, Pavel Kopnin
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Changes in the Structure of Potato Virus A Virions after Limited in situ Proteolysis According to Tritium Labeling Data and Computer Simulation Biochemistry Moscow (IF 2.8) Pub Date : 2023-12-27 Alexander L. Ksenofontov, Ludmila A. Baratova, Pavel I. Semenyuk, Natalia V. Fedorova, Gennadii A. Badun
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Relationships among Development, Growth, Body Size, Reproduction, Aging, and Longevity – Trade-Offs and Pace-Of-Life Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Rong Yuan, Erin Hascup, Kevin Hascup, Andrzej Bartke
Abstract Relationships of growth, metabolism, reproduction, and body size to the biological process of aging and longevity have been studied for decades and various unifying “theories of aging” have been proposed to account for the observed associations. In general, fast development, early sexual maturation leading to early reproductive effort, as well as production of many offspring, have been linked
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Potential Geroprotectors – From Bench to Clinic Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Alexey A. Moskalev
Abstract Geroprotectors are substances that slow down aging process and can be used for prevention of age-related diseases. Geroprotectors can improve functioning of various organ systems and enhance their homeostatic capabilities. We have developed a system of criteria for geroprotectors and proposed their classification based on the mechanisms of their action on the aging processes. Geroprotectors
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DNA Instability in Neurons: Lifespan Clock and Driver of Evolution Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Varvara E. Dyakonova
Abstract In the last ten years, the discovery of neuronal DNA postmitotic instability has changed the theoretical landscape in neuroscience and, more broadly, biology. In 2003, A. M. Olovnikov suggested that neuronal DNA is the “initial substrate of aging”. Recent experimental data have significantly increased the likelihood of this hypothesis. How does neuronal DNA accumulate damage and in what genome
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Olovnikov, Telomeres, and Telomerase. Is It Possible to Prolong a Healthy Life? Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Yegor E. Yegorov
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“If I Were in Nature’s Place, I Would Do It Like This...” Life and Hypotheses of Alexey Olovnikov Biochemistry Moscow (IF 2.8) Pub Date : 2023-11-30 Natalia I. Olovnikova, Ivan A. Olovnikov, Alla I. Kalmykova