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Design, synthesis, antimicrobial evaluation, molecular docking studies, and in silico prediction of ADME properties for novel pyrazolo[1,5‐a]pyrimidine and its fused derivatives J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-27 Fathi B. Nour Eldeen, Sayed A. S. Mousa, Ismail M. M. Othman, Mohamed I. H. El‐Qaliei
Dienamine 2 was synthesized by reacting 5‐aminopyrazole 1 with two moles of (DMF DMA). Enamine 2 underwent subsequent reactions with various reagents in different reaction media, leading to the formation of distinct compounds. In an acidic environment, enamine 2 reacted with acetyl acetone, benzoyl acetone, dimedone, and ethyl acetoacetate, resulting in the synthesis of compounds 9a, 9b, 13, and 17
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Synthesis and characterization of novel biheterocyclic compounds from 3‐alkoxy‐1H‐pyrazole‐4‐carbaldehydes via multicomponent reactions J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-27 Viktorija Savickienė, Aurimas Bieliauskas, Sergey Belyakov, Algirdas Šačkus, Eglė Arbačiauskienė
Several series of novel biheterocyclic compounds have been synthesized starting from 3‐alkoxy‐1H‐pyrazole‐4‐carbaldehydes and employing different types of multicomponent reactions. The structures of the obtained 4‐(pyrazol‐4‐yl)pyrano[2,3‐c]pyrazole, 4‐(pyrazol‐4‐yl)pyrazolo[4′,3′:5,6]pyrano[2,3‐b]quinoline, 4‐(pyrazol‐4‐yl)pyridine, and 4‐[(pyrazol‐4‐yl)methylidene]‐1,2‐oxazole derivatives were thoroughly
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Iron‐catalyzed intermolecular and intramolecular cyclization reactions of N‐heterocycles J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-26 Jyoti Kaushik, Sonika Jain, Dharma Kishore, Jaya Dwivedi
N‐Heterocyclic compounds have been appealing pharmacophores in their use as drug production substrates. In this review paper, the cyclization of N‐heterocycles, using iron as a catalyst, and their mechanistic pathways have been highlighted and presented comprehensively. This paper will provide researchers with in‐depth knowledge of their approach to synthesis by employing a greener way rather than
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Synthesis, characterization, and antibacterial activity studies of β‐lactam capped silver nanoparticles J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-23 Aarti Thakur, Suvidha Pandey, Mona Mittal, Renu Thapar
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Discovery of novel heterocyclic derivatives containing oxadiazolone or pyrimidinone cores as DPP‐4 inhibitors J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-23 Sidney Gustavo Diniz Feitosa, Ilária Martina Silva Lins, Larissa Gonçalves Maciel, Janaína Versiani dos Anjos
Type 2 diabetes is a chronic disease characterized by insulin resistance and alterations in incretin secretion, such as the glucagon‐like peptide‐1 (GLP‐1) hormone. GLP‐1 plays a crucial role in signaling insulin production in the pancreas, with its activity regulated by the dipeptidyl peptidase 4 (DPP‐4) enzyme. DPP‐4 presents an intriguing strategy for controlling type 2 diabetes. This study focuses
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N‐Azidoethyl azoles through N‐alkylation under highly harmonized reaction conditions: Synthesis, characterization, and complexation as energetic coordination compounds J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-22 Lukas Bauer, Simon M. J. Endraß, Thomas M. Klapötke, Jörg Stierstorfer, Nicole Zeitlmeir
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Imidazo[1,2‐α] azine's esters increase selectivity and anti‐inflammatory activity in microglial cells J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-21 Miguel G. González, M. Elena Campos Aldrete, Marco A. Ríos
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Novel 9H‐flouren containing indoline scaffolds: Synthesis, characterization, antimicrobial assays, and molecular docking study J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-21 Balraju Gangapuram, Prakash Gupta Tanguturi, Nisarg Gohil, Gargi Bhattacharjee, Vijai Singh, Dhanaji P. Rajani, Rajesh Bhosale, Jhillu Singh Yadav
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Double Mannich reaction with ketones as a route to heterocyclic systems: A mini review J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-21 Elsayed M. Afsah
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Synthesis, anticancer evaluation and in silico studies of novel N‐substituted arylidenethiazolidine‐2,4‐dione derivatives as adenosine monophosphate‐activated protein kinase activators J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-19 Savankumar R. Chothani, Chirag A. Chamakiya, Rupal J. Joshi, Manisha B. Karmur, Sheetal B. Karmur, Hardik L. Varu, Raghuvir R. S. Pissurlenkar, Anilkumar S. Patel, Naval P. Kapuriya
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Synthesis of a novel fused thieno‐pyrimidine with tetrazole analogs J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-13 Muthirevula Rajeswari, Begari Nagaraju, Venkata Rao Chunduri, Bhekumuzi Gumbi, Suresh Maddila
This current investigation represents the new series of fused thieno‐pyrimidine with synthesized tetrazole analogs (6a–j). Intermediates thieno‐[2,3‐d]‐pyrimidine were prepared by utilizing the Gewald method, and tetrazole (5a–j) was synthesized by [3 + 2] cycloaddition of azide and appropriate nitrile. All the prepared novel molecules were characterized and confirmed by 1HNMR, 13CNMR, LC‐MS, and FT‐IR
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Formal synthesis of 10‐Hydroxy‐6‐Aryldibenzo[b,g][1,8]Naphthyridin‐11(6H)‐ones from 2‐chloroquinolin‐3‐carbaldehydes and 3‐(Arylamino)cyclohexenones J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-13 Han‐Joo Lee, Joo‐Hyun Jeon, Jin‐Hee Kim, Hitesh B. Jalani, Jin‐Hyun Jeong
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One pot synthetic approach to 2‐methyl‐5‐phenyl‐7‐amino‐[1,3,4]‐thiadiazolo[3,2‐a]pyrimidine‐6‐carbonitrile derivatives with antifungal evaluation J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-12 Rimpi Saikia, Jumi Bharali, Sukanya Borthakur, Pabitra Kumar Kalita, Pradyut Sarma, Prakash Jyoti Saikia, Mintu Maan Dutta, Susanta Kumar Borthakur
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Ionic liquid‐supported copper‐catalyzed synthesis of 2H‐indazoles under microwave irradiation J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-11 Upala Dasmahapatra, Kaushik Chanda, Barnali Maiti
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Synthesis of hydantoins from N‐Boc protected amino acid derived amides using polymer‐supported PPh3/CBr4 as a reagent J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-09 Gordana Tasic, Nikola Mitrovic, Milena Simic, Mladen Koravovic, Predrag Jovanovic, Milos Petkovic, Milos Jovanovic, Branka Ivkovic, Vladimir Savic
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Recent developments in synthetic strategies and pharmacological outcomes of synthetic xanthine oxidase inhibitors: A comprehensive review J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-05 Gurinder Kaur, Rajiv Sharma, Ashu, Geetakshi Arora, Atamjit Singh, Preet Mohinder Singh Bedi, Kundan Singh Bora
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New energetic 1,2,4‐triazole‐nitrofuroxan hybrids J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-03-06 Alexander A. Larin, Ekaterina V. Dubasova, Ivan V. Ananyev, Konstantin A. Monogarov, Galina A. Gazieva, Leonid L. Fershtat
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Regioselective synthesis of (Z)‐5‐methylene‐containing morpholin‐2‐ones J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-02-26 Adriano F. Camargo, Genilson S. Pereira, Mateus Mittersteiner, Mário A. Marangoni, Paulo A. Moraes, Helio G. Bonacorso, Marcos A. P. Martins, Nilo Zanatta
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Synthesis of 1-(4-hydroxybutyl)-2-benzoyl indoles from 2-pyrrolidine benzaldehydes and α-bromoacetophenones in deep eutectic solvent J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-02-20 Guofang Jiang, Can Zhang, Xiaohong Xing, Jinbo Ouyang, Hong Yang, Zongbo Xie, Zhanggao Le
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Synthesis of benzo[b]pyran, 3,4 dihydropyrano[c]chromene and their new furan derivatives using Cu(II) complex of tetradentate Schiff‐base supported on silica as a nanocatalyst J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-02-21 Hashem Sharghi, Elahe Mashhadi, Seyyede Faeze Razavi, Mahdi Aberi
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Synthesis and biological evaluation of 3-hydroxypyrazoles as aquaporin 9 inhibitors J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-02-15 Subramani Selvi, Arun Kannan, John M. Jayaraj, Thangavel Selvi, Muthusamy Karthikeyan, Chidambaram Prahalathan, Natarajan Sampath, Kannupal Srinivasan
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Synthesis of tricyclic pyrazolopyrimidine arylidene ester derivatives and their cytotoxic and molecular docking evaluations J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-02-14 Tong Lu, Lifei Nie, Dan Tang, Khurshed Bozorov, Jiangyu Zhao, Haji Akber Aisa
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Novel oxadiazole functionalized pyridopyrimidine derivatives; their anticancer activity and molecular docking studies J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-02-13 Raghu Dasari, Srinivas Gali, Rajashekar Korra, Namratha Vaddiraju
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Synthesis of novel [1,2,3]triazolo[4′,5′:3,4]pyrrolo[1,2-a]thieno[2,3-d] pyrimidines: Potent EGFR targeting anti-breast cancer agents J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-29 Rajkumar Samala, Ranadheer Kumar M, Ashok Kumar Bapuram, Venkatarathnam Nasipireddy, Sirassu Narsimha
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Microwave-assisted synthesis of benzo[4,5]imidazo[1,2-a]pyrimidines and pyrano[4,3-b]pyrans catalyzed by L-glutamine functionalized magnetic nanoparticles in water:ethanol mixture J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-28 Aiborlang Thongni, Rishanlang Nongkhlaw, Chayan Pandya, Akella Sivaramakrishna, Paige M. Gannon, Werner Kaminsky
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Chemoselective direct amidation of fatty acids with furfurylamine without coupling reagents in reversed micellar microenvironment J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-26 Ayhan Yıldırım, Mehmet Suat Aksoy
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[3 + 2] Cycloaddition of nitrile oxides to dichloropropenes and 1,3-dichlorobut-2-ene: A regioselectivity issue J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-24 Alexandra N. Shilova, Nina S. Shatokhina, Evgeniy V. Kondrashov
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Application of the aza-Wittig reaction for efficient synthesis of diversely substituted benzo[f]Chromeno[2,3-d]pyrimidine and benzo[f]chromeno[2,3-d][1,2,4]triazolopyrimidine derivatives J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-23 Mohamed Hassan, Magda A. Barsy, Eman A. El Rady, Abdullah Sulaiman Al-Ayed, Mona Frempong, Kamal U. Sadek
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Synthesis and characterization of a highly fluorescent benzofuran dimer derived from estradiol J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-23 Gerardo I. Santiago-Sampedro, Martha C. Mayorquín-Torres, Andrés Aguilar-Granda, Martin A. Iglesias-Arteaga
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Dearomative [4 + 2] cycloaddition of 3-nitroindoles with ortho-amino Morita−Baylis−Hillman carbonates to forge indole-fused quinolines J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-16 Kai-Kai Wang, Yan-Li Li, Lan-Xin Li, Wei-Wei Yao, Ya-Fei Li, Wen-Fei Wang, Rongxiang Chen, Yi-Fan Hu, Aili Sun
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Novel pyrazole-biphenyl-carboxamides for SARS-CoV2 entry-level restriction and microbial infections J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-16 Shanmugha Samy, Milind Shrinivas Dangate, Manikandan Alagumuthu
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Manipulating sensitivities of planar oxadiazole-based high performing energetic materials J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-15 Ajay Kumar Chinnam, Jatinder Singh, Richard J. Staples, Jean'ne M. Shreeve
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Synthesis and antiviral activity of novel imidazo[2,1-b]thiazoles coupled with morpholine and thiomorpholines J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-10 Nagaraju Chirra, Varshitha Shanigarapu, Naga Pranathi Abburi, Ekaterina O. Sinegubova, Ravi Kumar Pedapati, Yana L. Esaulkova, Vladimir V. Zarubaev, Srinivas Kantevari
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Synthesis, antiproliferative activity, 3D-QSAR, and molecular docking studies of novel L-carvone-derived pyrimidine-urea compounds J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-09 Yupei Meng, Yunxue Zhang, Wengui Duan, Guishan Lin, Yucheng Cui, Baoyu Li
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Sc(OTf)3-catalyzed tandem (3+3)-annulation/lactonization of cyclopropanes with salicylaldehyde nitrones to access polycyclic 1,2-oxazines J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-07 Zhiping Liu, Jie Pang, Lijie Che, Liping Pang, Chunfang Gan, Jianguo Cui, Yanmin Huang
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Cu-catalyzed dehydrogenative C?O arylation for the synthesis of 6-methyl benzofuro[3,2-c] quinoline derivatives J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-07 Bhavik S. Makwana, Mayur I. Morja, Prakashsingh M. Chauhan, Kishor H. Chikhalia
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Visible light-mediated photocatalyzed synthesis of oxazole via intermolecular C?N and C?O bond formation J. Heterocycl. Chem. (IF 2.4) Pub Date : 2024-01-03 Mohd Zaheeruddin Beg, Shraddha Tivari, Akanksha Kashyap, Pravin K. Singh, Praveen P. Singh, Pankaj Nainwal, Vishal Srivastava
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Design, enantioselective synthesis, and antiviral activities against potato virus Y of axially chiral thiazine derivatives J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-26 Tingwei Shen, Jiamiao Jin, Jia Song, Hira Naz, Zhichao Jin, Yonggui Robin Chi, Xingxing Wu
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Catalyst-free one-pot synthesis of 2,4,5-tri- and 1,2,4,5-tetrasubstituted imidazoles J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-27 Priyanka V. Bandivadekar, Ganesh U. Chaturbhuj
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One-pot green synthesis, study of fluorescence properties, and biological activity of pyrano[3,2-c]chromenes derivatives via mesoporous materials MgO/SBA-15 J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-27 Ahmed Chelihi, Ridha Hassaine, Souad Nachat, Mohammed Benabdallah, Karima Bendahou, Mohammed Aissaoui, Merzouk Saidj, Ahmed Djafri, Leïla Boukenna, Abdelghani Bouchama, Noureddine Choukchou-Braham, Nadia Taibi
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Role of aurone ligands in microwave enhanced Mn (II) and Co (II) catalyzed dehydrogenative coupling reaction: An efficient ligand for the synthesis of quinoline, pyridine, and pyrrole J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-23 Shachi Mishra, Chandan Prakash, Bhartendu Pati Tripathi
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Amine and nitramine functionalization of imidazole-triazine and triazole-triazine skeletons: Exploring for potential multipurpose energetic materials J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-19 Abhishek Kumar Yadav, Manojkumar Jujam, Vikas D. Ghule, Srinivas Dharavath
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Research progress of triazole derivatives in the discovery of agricultural chemicals J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-18 Hongyi Song, Sheng Wang, Qingfeng Cai, Jixiang Chen
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Regiospecific synthesis of novel spiro-pyrimidobarbiturates with promising antibacterial activities J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-18 Bahgat R. M. Hussein, Amr H. Moustafa
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4-substituted push-pull quinazoline chromophores with extended π-conjugated linker J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-13 Thibault Bonnaud, Mathieu Scaviner, Françoise Robin-le Guen, Sylvain Achelle
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An eco-friendly, sustainable, and greener approach to the synthesis of Dihydroquinazolin-4(1H)-ones using a deep eutectic solvent J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-10 Gobind Kumar, Pule Seboletswe, Neha Manhas, Parvesh Singh, Gaurav Bhargava, Jaspreet Kaur Rajput, Rupesh Kumar
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Synthesis of potential impurities of cloxacillin sodium drug substance J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-04 Gollapalli Venkateswara Rao, Santhosh R. Pindi, Bollikolla Hari Babu, Bala Murali Krishna Khandapu
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Synthesis of nitro-containing isoquinoline-1,3-diones with tert-butyl nitrite J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-03 Hongsheng Ma, Tongyan Yu, Siliang You, Ming-Zhi Zhang, Chao Deng
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Hantzsch-like synthesis of isoquinolino[2,1-a]quinoline-12-carbonitrile incorporating aryl or heteroaryl moieties at C-13 J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-12-03 Mohamed A. Mohamed Teleb, Hamdi M. Hassaneen, Ismail A. Abdelhamid, Fatma M. Saleh
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New thieno[2,3-d]pyrimidine derivatives as EGFRWT and EGFRT790M inhibitors: Design, synthesis, antiproliferative activities, docking studies, ADMET, toxicity, MD simulation studies J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-11-27 Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Ibrahim H. Eissa
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Glycerol-1,2-carbonate: A mild reagent for the N-glycerylation of pyrazolecarboxylates J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-11-27 Inesa Zagorskytė, Aurimas Bieliauskas, Milda Pukalskienė, Patrick Rollin, Eglė Arbačiauskienė, Algirdas Šačkus
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Arylhydrazine salt-selenium: A novel and efficient reagent system for arylselenenylation of unprotected uracil and its derivatives J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-11-27 Yi Wu, Qi-Yun Peng, Yan-Ling He, Xiao-He Zheng, Yan-Qin Chen, Hai-Bo Wang, Bing Wang, Jun Xie, Lei Tang, Cong Wang
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Indeno[1,2-b]pyridin-5-one derivatives containing azo groups and their hydrazonal precursors: Synthesis, antimicrobial profile, DNA gyrase binding affinity, and molecular docking J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-11-21 Refaie M. Kassab, Zeinab A. Muhammad, Sami A. Al-Hussain, Magdi E. A. Zaki, Mona H. Ibrahim, Amani M. R. Alsaedi, Thoraya A. Farghaly
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From 2011 to 2022: The development of pyrazole derivatives through the α,β-unsaturated carbonyl compounds J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-11-22 Shubham Sharma, Virender Singh, Vaishali, Rakesh Kumar, Rahul Jamra, Naveen Banyal, Jyoti
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Cover Image J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-11-15 Aravinda Babu, K. Sunil, Ayyiliath Meleveetil Sajith, Nibin Joy Muthipeedika, Sougata Santra, Grigory V. Zyryanov
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Synthesis and characterizations of some new selenolo[2,3-b]quinoxaline derivatives J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-11-15 Fatma K. Abdelwadoud, Gehad S. Gomaa, Ahmed A. Geies
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Cobalt perchlorate hexahydrate catalyzed one-pot synthesis of dihydropyrimidin-ones/-thiones through sonochemistry and its mechanistic study using density functional theory calculations J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-11-13 Ramesh Ambatwar, Sumit Kumar, Dhairiya Agarwal, Lokesh Chandrakar, Gopal L. Khatik
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Organocatalyzed cycloaddition reactions of azomethine imines—A lookback J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-11-08 Bastin K. Jose, Athulya Simon, Niranjana Subrahmanian, P. Adhwithi, Sindhu Mathai
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An operationally simple, one-pot, convenient synthesis, and in vitro anti-inflammatory activity of some new spirotriazolotriazine derivatives J. Heterocycl. Chem. (IF 2.4) Pub Date : 2023-11-08 Ahmed M. El-Saghier, Souhaila S. Enaili, Aly Abdou, Amany M. Hamed, Asmaa M. Kadry