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Hemisynthesis of Pentacyclic Triterpenoids from Diospyros foxworthyi with in vitro and in silico Anti-malarial Evaluation Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-17 Muhammad Solehin Abd Ghani, Nur Ain Latifhaa Abu Bakar, Arba Pramundita Ramadani, Arde Toga Nugraha, Khalijah Awang, Mohammad Tasyriq Che Omar, Unang Supratman, Ezatul Ezleen Kamarulzaman, Mohamad Nurul Azmi Mohamad Taib
: A total of twelve pentacyclic triterpenoid derivatives based on betulin (1) and lupeol (2) scaffolds isolated from Diospyros foxworthyi were hemisynthesized by acylation or acetylation reactions with appropriate acid chloride or acetic anhydride. The structures of the hemisynthesised compounds were characterised by means of FT-IR, 1D- and 2D-NMR, as well as HRMS analysis. These compounds were assayed
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Recent Developments in Asymmetric Nazarov Reactions Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-17 Hélène Pellissier
:: The Nazarov reaction involves the cyclization of divinyl ketones into cyclopentenones under the influence of strong acids. The prevalence of five-membered carbocycles in a multitude of natural and bioactive products has triggered an intense development of efficient methods for their construction. In particular, asymmetric versions of the Nazarov reaction are achieved by using either a chiral auxiliary
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Recent Progress in the Synthesis and Biological Assessment of Benzimidazole-1,2,3- Triazole Hybrids Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-17 Dileep Kumar Singh, Haider Iqbal, Mohd Ayub Ansari
:: In recent times, many research groups have focused their attention on nitrogen-containing heterocyclic compounds with the aim of gaining a deeper understanding of their biological characteristics. Among them, molecules based on 1,2,3-triazole and benzimidazole have exhibited diverse biological applications and are present in many drug molecules. The purpose of this review is to describe various
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Organocatalyst 1,4-diazabicyclo [2.2.2]Octane (DABCO)-Catalyzed Sustainable Synthesis of Bis-Thiazolidinones Derivatives and their Spectral and DFT Analysis Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-17 Saloni Sahal, Mamta Chahar, Har Lal Singh, Renu Bishnoi, Sarita Khaturia
: Organocatalyst 1,4-diazabicyclo [2.2.2]octane (DABCO) has proven to be an efficient and environmentally friendly catalyst in the multicomponent reaction involving aldehydes, ethylenediamine, and thioglycolic acid under microwave conditions. DABCO stands out among other organic catalysts due to its costeffectiveness, non-toxic nature, and environmentally conscious profile. The method employed in this
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Zn[L-proline]2 as an Efficient Catalyst for the Synthesis of Dihydro Pyrano Thiazole Derivatives via Cycloaddition Reaction in Aqueous Medium Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-16 Hany M. Abd El-Lateef, Thomas Nady A. Eskander, Mohammad Saleh Hussein Alzubi, Mai M Khalaf, Mahmoud Abd El Aleem Ali Ali El-Remaily
: In the current study, a zinc-linked amino acid complex was successfully synthesized as an efficient and recoverable catalyst for the synthesis of dihydro pyrano thiazole derivatives via the reaction of an aromatic aldehyde with malononitrile and rhodanine in one-pot, three-component reaction under green conditions. The structures of the new compounds were elucidated by elemental and spectral analyses
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Improved Stability of Aspergillus oryzae α-Amylase Immobilized on Polyaniline Tin Oxide Nanocomposites Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-13 Mohd Jahir Khan, Abrar Ahmad
: In the present study, an immobilization support, Polyaniline tin oxide nanocomposite (PANI-SnO2- NC) was synthesized by in situ polymerization of aniline and ammonium peroxydisulphate. The prepared nanocomposite was characterized by various state-of-the-art techniques. The average size of native SnO2-NPs and PANI-SnO2-NC was 65±19 nm and 93±15 nm, respectively. An important industrial enzyme, α-amylase
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Synthesis and In-Silico Studies of Ortho-Fluorinated Benzenesulfonamides as Putative Anti-CETP Agents Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-09 Reema Abu Khalaf, Lama Jaradat, Maha Habash
: Cardiovascular disease is one of the primary causes of death. Atherosclerosis produces artery constriction or obstruction, which can lead to a heart attack or stroke. Cholesteryl Ester Transfer Protein (CETP) is a protein that aids in reverse cholesterol transport. It promotes cholesteryl ester transfer from HDL to LDL and VLDL. So, inhibition of CETP by drugs limits cardiovascular disease by decreasing
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Synthesis, Structure, and Antimicrobial Properties of New Cobalt(II) Complexes with 1-Propargylimidazoles Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-09 Irina V. Sterkhova, Lidiya N. Parshina, Lyudmila A. Grishchenko, Tatyana N. Borodina, Lyudmila A. Belovezhets, Valentin A. Semenov
: Complexes of cobalt(II) chloride with 1-propargylimidazole, 1-propargyl-2-methylimidazole, and 1- propargylbenzimidazole ligands were synthesized and studied by FTIR spectroscopy and X-ray analysis. According to the X-ray analysis, the crystal molecules of compounds were connected by non-covalent interactions, such as halogen bonds and π-stacking. The nature and energy of coordination metal-ligand
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Syntheses and Spectroscopic Characterization of Selected Methyl Quinolinylphosphonic and Quinolinylphosphinic Acids; Rationalized Based on DFT Calculation Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-05 Jacek E. Nycz, Nataliya Karaush-Karmazin, Boris Minaev, Valentina Minaeva, Jan G. Małecki, Maria Książek, Daniel Swoboda, Joachim Kusz
The quinoline derivatives arouse interest due to their broad spectrum of activity. The phosphorus compounds under investigation, quinolinylphosphonic and -phosphinic acids and aminophenylphosphonic and -phosphinic acids, possess potent bioactive properties, mimicking amino acids, phosphate esters, anhydrides, or carboxylate groups in enzymes. Despite its potential value, there is no reported example
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Palladium-charcoal Catalyzed Direct Esterification of Aldehydes to Esters by NaIO4 Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-04 Md. Mohinuddin, Kajol Ahmed, Izarul Islam, Anamul Hossain, Harendra N. Roy
:: An efficient direct oxidation method was developed to oxidize some aromatic and aliphatic aldehydes to esters by the dual utilization of NaIO4 and Pd-C. At ambient conditions, various aldehydes were employed in a clean esterification reaction to afford numerous esters in good to excellent yields. By this adopted method, some multifunctional aldehydes, high-energy-containing aromatic and unsaturated
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Exploring Synthesis and Medicinal Applications of Andrographolide Derivatives: A Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-04 Tanzeela Qadir, Shoaib Shaikh, Saadat A. Kanth, Jyotika Singh, Maria Baby, Praveen Kumar Sharma
: Andrographolide, derived from the plant Andrographis paniculata (AP), exhibits a diverse range of biological activities, encompassing anti-bacterial, anti-tumor, anti-inflammatory, anti-obesity, anti-viral, antifibrotic, hypoglycemic, and immunomodulatory properties. Notably, numerous analogs of andrographolide have been synthesized, incorporating significant chemical structural modifications to
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Synthesis of Aromatic Azides using Different Methodologies Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-03 Elisa Leyva, Silvia E. Loredo-Carrillo
:: For several decades, aromatic azides have been applied in diverse areas of research like synthesis of organic compounds, novel materials and photoaffinity labeling of biomolecules. The discovery of click chemistry and bioorthogonal chemistry expanded their applications. Currently, they are extensively used in biology, biochemistry and medicine. For many years, aromatic azides were usually prepared
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Synthesis, Characterization, Antimicrobial Activity, and Molecular Docking Study of Newer Chalcone-based Triazolo Pyrimidine Compounds Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-02 Monik Gohil, Siva Prasad Das, Jeena Jyoti Boruah
:: In this work, we present the synthesis of a newer series of 15 chalcone-based pyrimidine compounds 4a-o. All the compounds were characterized by elemental analysis, melting point determination, mass, FTIR, and NMR analysis. We have evaluated the antimicrobial activity of these compounds. The compounds showed good inhibition activity towards different bacterial and fungal species such as S. aureus
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A Review on the Development of Polymer Supported Heterogeneous Palladium Materials for Organic Synthesis and Electrochemical Applications Curr. Org. Chem. (IF 2.6) Pub Date : 2024-04-02 Ashlesha P. Kawale, Nishant Shekhar, Arti Srivastava, Subhash Banerjee
:: This comprehensive review explores the advancements in catalytic transformation, focusing on the use of heterogeneous catalytic systems with a particular emphasis on polymeric-supported palladium (Pd) complexes. This study explores the limitations associated with conventional homogeneous reagents, emphasizes the transition to eco-friendly catalytic systems, and emphasizes the importance of Pd nanoparticles
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Chirality Sensing in Coordination-driven Supramolecular Assemblies Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-28 Abhik Paul, Subhadip Roy
: Chirality is a widespread structural characteristic found in nature and plays a vital role in the structure and functioning of almost all biological systems. Nevertheless, the translation of chirality into synthetic systems is highly intricate yet captivating, as it not only applies fundamental understanding but also has the potential to tackle significant difficulties in biochemistry and medicine
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Multicomponent 3D-printed Collagen-based Scaffolds for Cartilage Regeneration: Recent Progress, Developments, and Emerging Technologies Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-25 Babak Mikaeeli Kangarshahi, Seyed Morteza Naghib
: Cartilage tissue presents challenges in terms of repair and regeneration due to its inherent limitations in self-healing and the scarcity of available donors. Cartilage damage can result in the development of joint problems characterized by symptoms, such as pain, swelling, and osteoarthritis. Collagen scaffolds are extensively used as biomimetic substances for cartilage engineering due to their
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Synthesis of Polypeptides by Ring-opening Polymerization: A Concise Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-25 Mostafa Badreldin, Pedro Salas-Ambrosio, Marcela Ayala, Simon Harrisson, Colin Bonduelle
: The most economical and efficient route to prepare polypeptides from synthetic chemistry is through the Ring-Opening Polymerization (ROP) of amino acids using N-carboxyanhydride (NCA) monomers. Peptide polymers, in contrast to proteins, consist of repeated amino acid units and are comparatively simpler macromolecules. Despite their simplicity, these polypeptides offer a unique combination of beneficial
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The Chemistry of Aldehydes and Ketones in the Synthesis of Heterocycles - Historical Reactions with a New and Green Perspective Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-19 Flavia Martins da Silva, Joel Jones Junior, July A. Hernández Muñoz
: The reactivity of aldehydes and ketones carries great potential for multicomponent heterocyclizations. These reactions are convergent and highly versatile in the development of synthetic methodologies for compound families, displaying variations in substituents in their structures. Therefore, they have been regarded as an important tool in the field of Green Chemistry. Furthermore, they prove to
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One-Pot Multicomponent Synthesis of Pyrano[2,3-c]pyrazole and 2-Amino-4Hbenzo[ b]pyrans Catalyzed by Hercynite@SiO2@Tris as Novel and Efficient Nanocatalyst Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-19 Shima Beiranvand, Masoomeh Norouzi, Bahman Tahmasbi
: In this study, magnetic hercynite nanoparticles (FeAl2O4, MNPs) were functionalized by cheap and readily available tris(hydroxymethyl)aminomethane (Tris) as an organocatalyst. Various techniques, including Vibrating Sample Magnetometry (VSM), Energy Dispersive X-ray Spectroscopy (EDS), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Thermogravimetric Analysis (TG) were employed to
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3D Printing Chitosan-based Nanobiomaterials for Biomedicine and Drug Delivery: Recent Advances on the Promising Bioactive Agents and Technologies Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-18 Seyed Morteza Naghib, Morteza Zarrineh, Mohammad R. Mozafari
3D bioprinting is a novel technology that has gained significant attention recently due to its potential applications in developing simultaneously controlled drug delivery systems (DDSs) for administering several active substances, such as growth factors, proteins, and drug molecules. This technology provides high reproducibility and precise control over the fabricated constructs in an automated way
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Cobalt(III)–porphyrin Complex as an Efficient and Recyclable Homogeneous Catalyst for the Synthesis of Tetrahydro-2-oxa-4-thia-diazapentalen-5-one Derivatives in Aqueous Medium Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-18 Hany M. Abd El-Lateef, Thomas Nady A. Eskander, Mohammad Saleh Hussein Alzubi, Mai M. Khalaf, Mahmoud Abd El Aleem Ali Ali El-Remaily
In this study, we successfully synthesized the CoPHrn complex as an efficient and recyclable catalyst for the one-pot, three-component reaction of aromatic aldehydes, 2,4-thiazolidenedione, and hydroxylamine hydrochloride, leading to the synthesis of tetrahydro- 2-oxa-4-thia-diazapentalen-5-one derivatives under environmentally friendly conditions. The structures of the newly formed compounds were
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Synthesis, Molecular Docking, Anti-cholinesterase Activity, Theoretical Investigation, and Catalytic Effect of New Encumbered N-benzyladamantyl Substituted Imidazolidin-2-ylidene Carbene Pd-PEPPSI Complexes Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-18 Sofiane Ikhlef, Sarra Lasmari, Saber Mustapha Zendaoui, El Hassen Mokrani, Dahmane Tebbani, Nevin Gürbüz, Chawki Bensouici, Raouf Boulcina, Bachir Zouchoune, Ismail Özdemir
This study aimed to describe the preparation of novel PEPPSI type Pd(II)-NHC complexes bearing N-benzyladamantyl substituted imidazolidin-2-ylidene group. All synthesized compounds were characterized by using 1H-NMR and 13C-NMR spectroscopies, FTIR, and elemental analysis techniques. One of the objectives of this study was the synthesis of Pd-NHC complexes with AChE/BChE inhibition activities. Among
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Ionic Liquid-promoted the Synthesis of Structurally Diverse Pyrans, Pyran-annulated Heterocycles, and Spiropyrans Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-18 Bubun Banerjee, Manmeet Kaur, Anu Priya, Aditi Sharma, Arvind Singh
During the last two decades, non-conventional solvents, especially various ionic liquids, have been utilized as efficient reaction media as they can play a dual role as solvents and promoters. The use of ionic liquids as a medium increases the efficiency of the reactions due to their inherent features like high thermal stability, ability to act as a catalyst, non-volatility, high polarity, reusability
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Facile Synthesis of 2-Substituted Quinazolines via Ruthenium(II)-Catalyzed Acceptorless Dehydrogenative Coupling Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-15 Shulei Wu, Qianqian Lei, Zaoduan Wu, Huifang Xie, Chen Zhang, Yu Ye, Meiling Yi, Mingsheng Chen, Hao Xu, Zehua Yang
:: This study aims to develop a practical and facile one-pot synthesis of 2- substituted quinazolines. Using a commercially available and structurally simple ruthenium( II) complex as the catalyst to synthesize a series of quinazoline derivatives via acceptorless dehydrogenative coupling. The mechanism of this reaction was explored by control reaction and DFT calculation. This protocol offers access
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Importance and Green Synthesis of Amines: A Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-14 Ashok Raj Patel, Ishwar Patel, Subhash Banerjee
: Amines are “derivatives of ammonia” and important key intermediates for applications in the industrial, pharmaceutical, electronics, etc. They have been used to synthesize industrially important azo dyes, which are used to color various materials. Moreover, amine functionality is present in several important biological molecules. Biogenic amines are found in living organisms and play essential physiological
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Design, Synthesis, and Antimicrobial Evaluation of Novel Sulfonamide Modified with Azoles Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-13 Pratibha Periwal, Ashwani Kumar, Vikas Verma, Devinder Kumar, Mahavir Parshad, Meenakshi Bhatia, Sourbh Thakur
Sulfonamide, imidazole, and triazole chemical nuclei possess good antimicrobial potential. This study aimed to amalgamate sulfonamide, imidazole, and triazole moieties in a single molecular framework with the intent of improving their antimicrobial activities. The objective of this study was the synthesis of conjugates containing sulfonamide and azole moieties along with in vitro and in silico evaluation
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Investigation of the Role of Zirconia and Zirconia-containing Systems as Catalysts in Organic Transformations Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-12 Kobra Nikoofar, Negin Shaddel, Fatemehsadat Jozi
This review article discusses the applications of zirconia as a catalyst to promote various organic reactions and transformations. The article is subdivided into four main parts: 1) introduction, which consists of the history and introduction of zirconia, elaboration of its synthetic procedures, its application in various fields of science and technology with specified examples, and previously published
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Recent Advances in Hypervalent Iodine Reagents and m-CPBA Mediated Oxidative Transformations Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-12 Ravi Varala, Vittal Seema, Mohammed Amanullah, Seella Ramanaiah, Mohammed Mujahid Alam
Among the several peroxides available, meta-chloroperbenzoic acid (mCPBA) plays an efficient role of oxidizing reagent and is used for many oxidative transformations, such as oxidation of various functional groups, carbon-carbon, carbon-hetero bond formation, heterocyclic ring formation, heteroarylation, oxidative cross-coupling, lactonization, oxidative dearomatization, α-oxytosylation or α-acetoxylation
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A Focussed Analysis of Β-cyclodextrins for Quinoxaline Derivatives Synthesis Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-12 Hena Khatoon, Emilia Abdul Malek
: Cyclodextrins (CDs), which are a type of cyclic oligosaccharides, are widely used in supramolecular chemistry. For example, they can be used to encapsulate volatile compounds, such as drugs, within their hydrophobic cavity. This encapsulation reduces the volatility of the compounds and helps to retain their desired properties. Due to its extraordinary properties, cyclodextrins have been utilized
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Synthetic Update on Antimicrobial Potential of Novel Pyrazole Derivatives: A Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-12 Sucheta Singh, Sumit Tahlan, Kuldeep singh, Prabhakar Kumar Verma
: Heterocyclic compounds containing nitrogen and their derivatives have been a rich source of medicines. Pyrazole, a five-membered ring structure, offers a variety of functionalities as well as stereo-chemical complexity. Studies conducted over the past 10 years revealed that an increasing amount of research has been performed on different pyrazole derivatives and their physiological and pharmacological
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Synthesis of Novel Propynyl Monoterpene Analogues and their Conjugates with β-DGlucopyranosides Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-08 Rinat R. Gubaidullin, Yulia A. Perfilova, Lyudmila V. Parfenova
Camphor and carvone exhibit a broad spectrum of biological activity, which determines the prospect of their use as a platform for functionalization to obtain the analogues as potential drugs. The functionalization of camphor and carvone often involves changes to the skeleton of the molecules or their fragmentation. Therefore, in modern medicinal chemistry, research aimed at the development of effective
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Overview of Synthesis and Applications of Unnatural Lipophilic α-Amino Acids Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-06 Prateek Bhamboo, Smritilekha Bera, Dhananjoy Mondal
: Naturally and synthetically obtained lipophilic α-amino acids exhibit diverse properties and applications in academia and industry. Unnatural hydrophobic/lipophilic amino acids lacking polarity in their side chains manifest the biologically significant structure of peptides and proteins. The hydrophobic effect of lipophilic amino acids stabilizes the structure of proteins, peptides, and enzymes during
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Enantioselective Zirconium-catalyzed Transformations Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-06 Helene Pellissier
: The cheaper and less-toxic metals of Group 4 compared with common metals used in catalysis are increasingly applied in catalysis, resulting in the development of many novel greener transformations. Zirconium is abundant, non-toxic, and exhibits a remarkably diversified chemical reactivity among these metals. Since the first asymmetric zirconium-catalyzed reaction disclosed by Nugent in 1992, a wide
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Using Supercritical Diethyl Ether as the Reaction Medium for the Synthesis of 3-Acetyl and 4-Methyl Substituted Coumarins Curr. Org. Chem. (IF 2.6) Pub Date : 2024-03-01 Zeynep Özsırkıntı, Abdul Hakim Hakimi, Mehmet Erşatır, Murat Türk, Onur Demirkol, Elife Sultan Giray
aims: Using supercrticial diethylether as a reaction solvent Abstract: Due to very good biological activity and use as fluorescent probes, coumarin synthesis and developing new synthesis methods are still an attractive area for many research groups. In this work, for the first time, a novel, mild, and green method has been developed for coumarin synthesis by using supercritical diethyl ether as a reaction
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Synthetic Approaches for Pyranoquinolines: A Concise Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-02-27 Angie D. Arboleda, Leydi M. Moreno, Rodrigo Abonia
: The pyranoquinoline frameworks have a wide distribution in natural products and have displayed a great amplitude of biological activities, attracting the attention of synthetic and medicinal chemists due to their usefulness in agrochemical and pharmaceutical industries. Among the twenty possible isomeric pyranoquinoline frameworks, research reports for only six of them that were found during the
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Recent Advances in Solvent-free Organic Transformation via Iron-doped Nanocatalyst Curr. Org. Chem. (IF 2.6) Pub Date : 2024-02-22 Dhananjay N. Gaikwad, Suresh T. Gaikwad, Rajesh K. Manjul, Anjali S. Rajbhoj, Dayanand M. Suryavanshi
This article highlights current developments in iron-doped nanocatalyst-based solvent-free organic reactions. These catalysts have the potential to speed up processes under safe environmental settings and eliminate the need for hazardous organic solvents. Its application in a variety of fields is mostly due to its superparamagnetic nano diameters, which are affordable, easily separable, reusable, and
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Recent Advances in Self-healing Polymer Materials: Routes and Strategies Curr. Org. Chem. (IF 2.6) Pub Date : 2024-02-22 Zhonglin Cao, Jinbao Xu
:: The most intriguing area of scientific study and engineering applications is to synthetize materials that can autonomously heal damage similar to biological tissues. Since the concept of self-healing materials was established, several variations of self-healing polymer materials have been developed based on distinct healing techniques. This review outlines the most recent breakthroughs in self-healing
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Synthesis of Unsymmetrical Diaryl Tellurides Under Mechanical Ball Milling in Room Temperature Curr. Org. Chem. (IF 2.6) Pub Date : 2024-02-21 Anup Roy, Subir Panja, Pradipta Kumar Basu, Debasish Kundu
An efficient transition metal catalyst-free protocol for the synthesis of unsymmetrical diaryl tellurides has been developed by the reaction of diaryl tellurides and aryl diazonium tetrafluoroborates under mechanical ball milling in the absence of any solvent and base under room temperature. InBr (Indium Bromide) plays an important role in generating the organotelluride nucleophile via the Te-Te bond
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A Review on Folklore Uses, Phytoconstituents and Pharmacological Activities of the Genus Berberis Curr. Org. Chem. (IF 2.6) Pub Date : 2024-02-20 Zulfa Nooreen, Awani Kumar Rai, Poonam Jaisal, Fariha Sumayya, Ankita Wal, Nasir A. Siddique
Genus berberis, an evergreen shrub of about 500 plant species found in subtropical and temperate regions but only some of them are investigated and evaluated for their phytochemistry and bioactivity. These plants are spread worldwide and help in the nourishment of humans and animals. Almost all parts of the plant are investigated for pharmacological and phytochemical purposes, including, roots, fruits
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Recent Advances in Synthetic Routes for Biologically Active Tetrahydroquinoxalines and Derivatives: A Comprehensive Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-31 Ashis Kumar Sahoo, Aditya Bhattacharyya
Tetrahydroquinoxalines are found in many biologically and pharmacologically active small molecules. In the past two decades, significant progress has been made in the development of novel synthetic routes for the preparation of biologically active tetrahydroquinoxalines and their derivatives. This synthetic review aims to provide a comprehensive overview of the advancements in the field of various
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Nano-Biocomposites: A Versatile Combination of Nanocomposites and Biopolymers for the Synthesis of Heterocycles via Multicomponent Reactions Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-31 Archana Rajmane, Arjun Kumbhar
Organic natural materials like chitosan, cellulose, starch, agarose, and alginate possess unique structures that are useful in creating advanced nanostructured materials. These materials are highly useful in catalysis because of their numerous functional groups and catalytic properties. They can also be combined with inorganic materials to create
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Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A Recent Update Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-31 Shivangi Jaiswal, Jaya Dwivedi, Dharma Kishore, Swapnil Sharma
Tetrazole is a most versatile pharmacophore of which more than twenty FDAapproved drugs have been marketed globally for the management of various diseases. In spite of many remarkable and consistent efforts having been made by the chemists towards the development of greener and sustainable strategies for the synthesis of tetrazole derivatives, this approach still needs more attention. The present review
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Anti-inflammatory Activity and Computational Biology Study of Indole/Pyrimidine Hybrids Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-30 Mostafa Sayed, Ahmed M. Sayed, Ahmed A. El-Rashedy, Abdelreheem Abdelfatah Saddik, Azhaar T. Alsaggaf, Adel M. Kamal El-Dean, Reda Hassanien, Mostafa Ahmed
: This research paper embarks on an interdisciplinary exploration encompassing synthetic chemistry, pharmacology, and computational biology. The development of novel anti-inflammatory agents is an imperative endeavor within pharmaceutical research. Pyrimidines and thienopyrimidines are class of heterocyclic compounds that have gained prominence for their diverse pharmacological properties, including
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Innovations in Treating Sporotrichosis: Drug Repurposing and Lead Compound Synthesis Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-29 Alcione S. de Carvalho, Gabriel R.M. de Freitas, Caroline D. Nicoletti, Fernando de C. da Silva, Débora O. Futuro, Vitor F. Ferreira, Patricia G. Ferreira
: Sporotrichosis, recognized by the World Health Organization (WHO) as a neglected tropical disease and classified among significant fungal health concerns, remains both underestimated and underreported. There is a profound impact of sporotrichosis on public health, affecting both humans and domestic animals. The causative agents are fungi within the Sporothrix genus, primarily transmitted through
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Part 2, Studies on the Synthesis of Quinolone Derivatives with their Biological Activity Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-29 Nishtha Saxena, Swapnil Shankhdhar, Anil Kumar, Nivedita Srivastava
Quinolones are among the class of antibiotics that are used most frequently worldwide and are used for treating a variety of bacterial diseases in humans. Recent research has shown that new, improved analogues of quinolones are being used as anticancer, antifungal, antiviral and other antimicrobial agents. In an earlier review (Part 1), we discussed the synthesis and antibacterial activity of quinolones
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Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Some Novel 3,5-disubstituted-1-phenyl-4,5-dihydro-1H-pyrazole Derivatives Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-26 Fatih Tok, İlayda Rumeysa Bayrak, Elif Karakaraman, İrem Soysal, Cansel Çakır, Kübra Tuna, Serap Yılmaz Özgüven, Yusuf Sıcak, Mehmet Öztürk, Bedia Koçyiğit-Kaymakçıoğlu
In this study, some new pyrazoline derivatives bearing cyano or nitro groups were synthesized. The structures of the compounds were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis data. The ABTS·+, DPPH·, CUPRAC and β-Carotene/linoleic acid assays were carried out to determine the antioxidant activity of the synthesized pyrazolines. Compound P14 showed higher antioxidant activity than the
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Two-step Continuous-flow Synthesis of 1,2-dimethyl-3-methylsulfanylbenzene via Diazotization and Methanethiolation Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-26 Lixia Li, Qi Zhang, Ce Bian, Wei Wei, Wenxuan Sun, Lu Ji, Hande Wang, Chuan Zhou, Ke Wang, Dangsheng Gong, Dongmao Yan
1,2-Dimethyl-3-methylsulfanylbenzene is the key intermediate of topramezone. This work designed a two-step continuous-flow device to synthesize 1,2-dimethyl-3- methylsulfanylbenzene via diazotization and methanethiolation. The results showed that compared with the batch process, the continuous-flow method greatly shortened the residence time to 1 minute, avoided the accumulation of large amounts of
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Organic Synthesis via Renewable Heterogeneous Nanocatalysts Based on Montmorillonite Clay Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-26 Mustafa M.H. Al-Abayechi, Abbas Al-Nayili, Asim A. Balakit, Gamal A. El-Hiti
Synthetic organic molecules are vital for human life, serving as medications, pesticides, dyes, and food additives. Organic synthesis provides routes for the production of these molecules. The traditional methods of organic synthesis require energy, solvents, time, and certain conditions based on the nature of the reactions. To address the issues associated with conventional processes, various environmentally
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Thiophene-based Solar Cell. A Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-24 Maurizio D'Auria, Lucia Emanuele
: In recent years, perovskite solar cells, which use a hybrid inorganic-organic material, have also made remarkable progress and achieved a rapid increase in efficiency. The organic materials used are usually small conductive molecules, polymers or oligomers. The fused thiophenes, polythiophenes and olithiophenes used for this purpose are presented. The condensed thiophene-based small molecule for
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Synthesis and Biological Evaluation of Cholic Acid Tagged Piperazine Derivatives Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-24 Dima W. Alshawabkeh, Anas J. Rasras, Saqr Abushattal, Mohammad S. Al Zubi, Mohamad M. Shakdofa, Eyad A. Younes, Raed A. Al-Qawasmeh
: Diseases caused by bacteria are a big challenge for scientists worldwide. These bacteria can be resistant through the adaption of new ways to protect themselves against antimicrobial drugs and thus become multidrug resistance. In this work, new derivatives of 1,3,4-oxadiazole- cholic acid were synthesized and fully characterized using different techniques, such as 1H-NMR, 13C-NMR, and HRMS. Their
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Enzyme Cocktails Catalyzed Bioconversion of Lignocellulosic Biomass into Bioethanol Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-24 Tianlun Dai, Jinshu Huang, Hongguo Wu, Hu Li
: Sustainable production of biofuels from lignocellulosic biomass (LBM) is considered one of the promising solutions to solve the current energy crisis caused by over-reliance on fossil fuels. Enzymatic hydrolysis is a crucial step in determining the efficient conversion of biomass cellulose into biofuels as well as high value-added chemicals, and it has the characteristics of efficient reaction, economy
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Recent Progress in the Synthetic Methods of Pyrazoloquinoline Derivatives Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-23 Rita M. Borik, Mohamed S. Mostafa, Mohamed S. Behalo, Rizk E. khidre
The focus of this review is on the synthetic routes available for different types of pyrazoloquinoline derivatives. There are three types of synthetic methods: i) from pyrazole derivatives; ii) from quinoline derivatives; and iii) miscellaneous methods. The position of the linkage between pyrazole and quinoline rings determines the seven isomers of pyrazoloquinolines. The purpose of this review is
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Nicotinamide Loaded Chitosan Nanocomplex Shows Improved Anticancer Potential: Molecular Docking, Synthesis, Characterization and In vitro Evaluations Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-23 Ahmed M. Metwaly, M. A. Abu-Saied, Ibraheem M.M. Gobaara, Asmaa M. Lotfy, Bshra A. Alsfouk, Eslam B Elkaeed, Ibrahim H. Eissa
: This study aimed to prepare and characterize chitosan nanoparticles encapsulating a nicotinamide derivative (Ni-CS-NP). Additionally, the therapeutic effectiveness, cytotoxicity, selectivity, and immunomod- ulatory properties of Ni-CS-NP were evaluated in human breast and colon cancer cell lines. Chitosan nanoparticles have shown potential as drug delivery carriers due to their biocompatibility and
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Design, Synthesis and Characterization of Deoxycholic Acid-chalcone Conjugates as Antioxidant Agents Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-17 Sejal Patel, Satyendra Mishra
The present article reports the synthesis, characterization, and antioxidant activity of the chalcone-deoxycholic acid conjugates. The structures of the synthesised bile acidchalcone conjugates have been determined using 1H and 13C NMR spectroscopy. According to the results of the DPPH experiment, compounds 5e (3, 4, 5-methoxy; IC50; 15.04 μg /ml) and 5f (4-hydroxy group; IC50; 11.73 μg /ml) had higher
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Harnessing the Pyrazine Moiety for Potent Anti-inflammatory Activity: A Comprehensive Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-12 Kuldeep Singh, Jeetendra Kumar Gupta, Kamal Saha, Sunam Saha, Marianesan Arockia Babu, Shivendra Kumar, Mohit Agrawal
Inflammation is an intricate physiological reaction that has a vital function in the body's protection against detrimental stimuli. Nevertheless, uncontrolled inflammation may result in the development of long-term conditions, such as arthritis, cardiovascular disorders, and even cancer. Scientists are always searching for new medicinal substances that might efficiently regulate the inflammatory response
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Recent Advances in Electrochemical Sulfonylation using Sodium Sulfinates as Sulfonyl Radical Precursors Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-04 Sen Liang, Jia-Xin Gu, Cheng-Chu Zeng
Sodium sulfinates have been widely utilized as sulfonyl radical precursors for preparing a diverse array of value-added sulfur-containing compounds (sulfones, sulfonamides, sulfonates, thiosulfonates, etc.) through S-C, S-N, S-O and S-S bonds formation reactions. Organic electrosynthesis has become an attractive alternative to conventional methods for redox reactions because it utilizes electric current
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Recent Advances in the Synthesis and Applications of Phenylquinoline-4-carboxylic Acid Derivatives: A Comprehensive Review Curr. Org. Chem. (IF 2.6) Pub Date : 2024-01-04 Sunam Saha, Devender Pathak, Kamal Shah
Phenylquinoline-4-carboxylic acid derivatives have garnered significant attention in recent years due to their diverse pharmacological and industrial applications. This comprehensive review summarizes the latest advancements in the synthesis and diverse range of applications of phenylquinoline-4-carboxylic acid derivatives. This review provides a brief overview of the significance of phenylquinoline-4-carboxylic
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Synthesis of Polyalkoxymethylenedioxy-1,4-naphthoquinones from Parsley Seed Metabolite Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-27 Alexander E. Varakutin, Egor A. Muravsky, Victor N. Khrustalev, Alexander V. Samet, Victor V. Semenov
A convenient synthesis of polyalkoxy-1,4-naphthoquinones, good starting materials for analogues of natural quinones, has been developed. Bromonaphthoquinone, more stable than its hydroxylated analogue, turned out to be a convenient and accessible key synthon for the preparation of various polyalkoxylated naphthoquinones. The obtained quinones could be useful starting materials for the preparation of
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Quinolone Tethered 1,2,3-triazole Conjugates: Design, Synthesis, and Computational Docking Studies on New Heterocycles as Potent Antimicrobial Targets Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-23 Avanthi Basireddy, Tejeswara Rao Allaka, Avekananda Reddy Allam, Sudhakar Reddy Baddam, Sravanthi Basireddy, Kishore Pilli VVN
: The synthesis and biological properties of molecules simultaneously comprising various heterocycles, such as fused 2-quinolones and 1,2,3-triazoles, have been evaluated as a part of our ongoing research in medicinal and organic chemistry. We were successful in developing a synthetic procedure for 1,2,3-triazole substituted quinolone derivatives. Infrared, proton, and carbon nuclear magnetic resonance
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Novel Chalcone Derivatives containing Pyridone and Thiazole Moieties: Design, Synthesis, Molecular Docking, Antibacterial, and Antioxidant Activities Curr. Org. Chem. (IF 2.6) Pub Date : 2023-12-23 Rita Borik
: A new series of chalcones 4a-i; 6a,b, and 8 was synthesized from the condensation of ketone 2, which was prepared from the reaction of thiourea derivative 1 with 3-chloropentane-2,4-dione in MeOH at reflux temperature, with substituted aromatic/heterocycle aldehydes in EtOH containing NaOH at room temperature. Antimicrobial and antioxidant activities were assessed for the synthesized compounds. The