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Study on the Catecholase Activity in the Presence of a Mn(III)-based Catalyst and Base Curr. Org. Synth. (IF 1.8) Pub Date : 2024-03-15 Rashmi Rekha Tripathy, Samaresh Jana, Sohini Sarkar
Background:: This work describes the oxidation of a catechol moiety to the corresponding quinone by using Mn(III)-based catalysts in the presence of an organic base. Two newly reported Mn(III)-Schiff base complexes were utilized for the oxidation of three different substrates, namely, 3,5-di tert-butyl catechol, 1,4-dihydroxy benzene and pyrocatechol, aerobically. Objective:: We intended to understand
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The Emerging Role of Polyethylene Glycol-Water (PEG-H2O) as the Benign Mixed Solvent System in Organic Synthesis Curr. Org. Synth. (IF 1.8) Pub Date : 2024-03-15 Chitteti Divyavani, Pannala Padmaja, Pedavenkatagari Narayana Reddy
: Polyethylene glycol (PEG) has become a popular solvent and green catalyst for a variety of chemical reactions. It is a stable and biodegradable polymeric catalyst used in organic synthesis because it may be recycled numerous times without significantly losing its catalytic activity. Recently, the use of PEG-H2O mixed solvent systems in organic synthesis has gained popularity. This article presents
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An Alternative Method for the Selective Synthesis of Ortho-nitro Anilines Using Bismuth Nitrate Pentahydrate Curr. Org. Synth. (IF 1.8) Pub Date : 2024-02-22 Brenda V. Loera-García, Socorro Leyva-Ramos, Jaime Cardoso-Ortiz, Saúl Noriega, Antonio Romo-Mancillas, Kim M. Baines, Sarah L. McOnei
Background: Nitroaromatic compounds are important scaffolds used for the syn-thesis of a variety of compounds, such as explosives, herbicides, dyes, perfumes and phar-maceuticals. Bismuth nitrate pentahydrate is a widely used reagent in organic synthesis; how-ever, its utility as a nitrating agent for anilines is underexplored. Objective: The aim of this work is to propose and find the proper reaction
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Mild and Efficient Preparation of N-Heterocyclic Organic Molecules by Catalyst-free and Solvent-free Methods Curr. Org. Synth. (IF 1.8) Pub Date : 2024-02-16 Zhiqiang Wu, Xuesong Li, Yueyi Li, Lin-an Cao, Zhenliang Li, Xuming Wang, Wanyi Liu, Enke Feng
Aims: The small organic molecular compounds with biological activity containing C-C and C-N or C-O bonding were efficiently prepared without catalyst and solvent in the hydrothermal synthesis reactor. Objectives: Our goal was to explore new applications for the more environmentally friendly and efficient synthesis of bis(indolyl)methyl, xanthene, quinazolinone, and N-heterocyclic derivatives in hydrothermal
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Research Progress on the Application of Nanocellulose in Glucose Sensing Curr. Org. Synth. (IF 1.8) Pub Date : 2024-02-16 Jianzhong Yuan, Caichao Wan, Song Wei, Huayun Chai, Tao Tao
Background:: Nanocellulose is not only a biocompatible and environmentally friendly material but also has excellent mechanical properties, biodegradability, and a large number of hydroxyl groups that have a strong affinity for water. These characteristics have attracted significant attention from researchers in the field of glucose sensing. Objective:: This review provides a brief overview of the current
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Synthesis, Characterization, and Molecular Modeling Studies of Novel In-denopyridazine-Thiazole Molecular Hybrids Curr. Org. Synth. (IF 1.8) Pub Date : 2024-02-13 Jehan Y. Al-Humaidi, Sobhi M. Gomha, AbdElAziz A. Nayl, Ashraf A. Aly, Mahmoud A. A. Ibrahim, Magdi E. A. Zaki, Stefan Braise, Reda A. Haggam
Background: Previous studies have reported various biological activities of indeno-pyridazine and thiazole derivatives, including antiviral activity and CoV-19 inhibition. In this pa-per, the authors aimed to design, synthesize, and characterize a novel series of indenopyridazinethi-azoles, starting with 2-(4-cyano-3-oxo-2,3-dihydro-9H-indeno[2,1-c]pyridazin-9-ylidene)-hydra-zine-1-carbothioamide and
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Changes in Germination Parameters, Growth and Development of Three Cultivars of Corn Seedlings under Various Aqueous Extracts of Mallow Curr. Org. Synth. (IF 1.8) Pub Date : 2024-02-07 Mehdi Khoshkharam, Mohamad Hesam Shahrajabian, Wenli Sun
: Allelopathy is related to the positive or negative impacts on one type of plant of a chemical produced by another type of plant, such as weeds, and different kinds of chemicals are hydroxamic acids, phenolics, and short-chain fatty acids. The potential allelopathic impacts of weeds are directly associated with the plant species used, as well as the concentration of the aqueous extract available in
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Recent Progress on Photonic Cellulose Nanocrystal Films for Sensing Applications Curr. Org. Synth. (IF 1.8) Pub Date : 2024-02-07 Zhijie Deng, Tao Tao, Jianzhong Yuan, Caichao Wan
: Cellulose nanocrystals (CNCs) have triggered considerable research interest in the last few years owing to their unique optical, biodegradation, and mechanical behavior. Herein, recent progress on the sensing application of photonic CNC films is summarized and discussed based on the analyses of the latest studies. We briefly introduce the three approaches for pre-paring CNCs: mechanical treatment
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Uremic Toxins Elimination from Simulated Intestinal Serum with Mesopo-rous Silica Nanoparticles Coupled with Molecularly Imprinted Polymers and Amino Linker Curr. Org. Synth. (IF 1.8) Pub Date : 2024-02-06 Leila Nazmi Miardan, Ebrahim Rezaii, Mehrdad Mahkam, Hamid Tayebi Khosroshahi
Background: One of the most researched issues is the elimination of uremic toxins from the human body. These toxins can build up and lead to catastrophic issues including renal failure. To get rid of them, absorbents like activated carbon, zeolites, and other minerals are frequently utilized. Methods: Mesoporous silica nanoparticles functionalized with (3-Aminopropyl) triethox-ysilane (APTES) linker
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A Brief Review on Recent Developments in Diels-Alder Reactions Curr. Org. Synth. (IF 1.8) Pub Date : 2024-02-04 Manish Chaudhary, Shareef Shaik, Muskan Magan, Sharwan Hudda, Mukta Gupta, Gurvinder Singh, Pankaj Wadhwa
: The [4+2] Diels-Alder cycloaddition has been widely used for the synthesis of six-mem-ber scaffolds. In recent years, there have been significant developments in this area, including the discovery and design of novel dienes and dienophiles with improved reactivity and selectivity. These new building blocks can be used to develop diverse molecular structures with functional group compatibility. Additionally
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One Pot Synthesis of New Benzimidazole Derivatives with Exceptionally High Luminescence Quantum Efficiency Curr. Org. Synth. (IF 1.8) Pub Date : 2024-01-21 Abraham Mensah, Xin-Ye Liu, Bing-Xiang Hu, Ennin Vendish Kweku, Fang-Ming Wang, Li-Zhuang Chen, Shao-Jun Zheng
Aim and Objzectives: There are different approaches to the synthesis of benzimidazole. In this article, five new benzimidazole derivatives, BMPO, Me-BMPO, Di-MeBMPO, F-BMPO and Cl-BMPO where (BMPO=3-[(1H)-benzo[d]imidazol-2-yl]pyridin-2(1H)-one), have been prepared. Another study was carried out on luminescence properties and their potential applica-tions for the detection of transition metal ions
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Synthesis and Antitumor Activity of Some New N1-(8-fluoro-4-oxoquinolin-5-yl)amidrazones Curr. Org. Synth. (IF 1.8) Pub Date : 2024-01-17 Hind M. A. Yahya, Jalal A. Zahra, Salim S. Sabri, Mustafa M. El-Abadelah, Sanaa Bardaweel
Background: Hydrazonoyl chloride, accessible from the respective 5-amino-8-fluoro-4-oxoquinoline-3-carboxylate, undergoes a reaction with sec-cyclic amines to generate N1-(1-ethyl-8-fluoro-4-oxoquinolin-5-yl)amidrazone carboxylates. background: The hydrazonoyl chloride, accessible from the respective 5-amino-8-fluoro-4-oxoquinoline-3-carboxylate, underwent reaction with sec-cyclic amines to generate
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A Review of the Synthesis of Oxazoline Derivatives Curr. Org. Synth. (IF 1.8) Pub Date : 2024-01-17 Cynthia Nathalia Pereira, Amanda Cristina Cruz Eschholz, Maurício Silva dos Santos
: Oxazolines are important heterocyclic systems due to their biological activities, such as antibacterial, antimalarial, anticancer, antiviral, anti-inflammatory, antifungal, antipyretic, and antileishmanial. They have been widely applied as chiral auxiliaries, polymers, catalysts, protecting groups, building blocks, and ligands in asymmetric synthesis. Due to their importance, many synthetic routes
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Organocatalytic Synthesis of (Hetero)arylidene Malononitriles Using a More Sustainable, Greener, and Scalable Strategy Curr. Org. Synth. (IF 1.8) Pub Date : 2024-01-13 Suzaimi Johari, Mohd Rafie Johan, Nader Ghaffari Khaligh
aims: More sustainable process for the synthesis of CS and (hetero-)arylidene malononitriles in the laboratory and industrial scale background: The different definition of zero waste has been presented by municipalities, communities, and organizations around the world. A definition of Zero Waste and a set of Zero Waste principles were adopted by the United States Conference of Mayors for the Hierarchy
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Regioselective Synthesis of Cycloalkane-fused pyrazolo[4,3-e]pyridines through Tandem Reaction of 5-aminopyrazoles, Cyclic Ketones and Electron-rich Olefins Curr. Org. Synth. (IF 1.8) Pub Date : 2024-01-12 Paola Cuervo-Prado, Fabián Orozco-López, Christian Becerra-Rivas, Diego Leon-Vargas, John Lozano-Oviedo, Justo Cobo
Background: Pyrazolopyridines are interesting fused heterocyclic pharmacophores that combine pyrazole and pyridine; two privileged nuclei extensively studied and with a wide range of applications. They can be obtained by a broad variety of synthetic methods among which multicomponent reactions have gained importance, especially from 5-aminopyrazoles and dielectrophilic reagents. However, the search
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Reactions and Biological Activities of Hydrazonoyl Halides Curr. Org. Synth. (IF 1.8) Pub Date : 2024-01-11 Munirah Alarbash, Yasir Al-Faiyz, Jeffery Wiggins, Abdelwahed Sayed
: This review covers the literature information on the chemistry of hydrazonoyl halides with different substrates to give heterocyclic compounds. From the foregoing survey, it seems this provides a useful and convenient strategy for the synthesis of numerous heterocyclic derivatives. The subject of such reactions is still ongoing and undoubtedly will provide new fused functionalized compounds of both
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Recent progress in free radical transformations of allenamides Curr. Org. Synth. (IF 1.8) Pub Date : 2024-01-04 Yongchun Liu, Zimin Wang, Rui Li, Yinhai Yao, Zhichuan Shi, Qin Sun, Guowei Deng
: Allenamides are special allenes, and the unique reactivity, selectivity (both stereoselective and regionally selective) and stability of allenamides have been widely studied. In this review, the development of the free radical transformation of allenamides over the last few years will be summarized. This review discusses in detail in three parts: intermolecular radical addition to C- X (X = N, S
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Heteroaromatization of Coumarin Part I: Design, Synthesis, Reactions, Antitumor Activities of Novel Pyridine and Naphthyridine Derivatives Curr. Org. Synth. (IF 1.8) Pub Date : 2024-01-01 Rita Mohammed Ahmed Borik, Ashraf Hassan Fekry Abd El-Wahab
A novel series of chromen-3-yl-pyridine moieties were synthesized. IR, NMR, and MS spectroscopy were used to confirm the structure of these novel compounds and study antitumor activity of these compounds. The structure-activity relationship investigation demonstrated that 2,4-diamino-5-(3-methoxyphenyl)-7-(2-oxo-2H-chromen-3-yl)-1,8-naphthyridine-3-carbonitrile (16), naphthyridine-3-carbonitrile derivatives
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Highly Efficient Bimetallic Catalyst for the Synthesis of N-substituted Decahydroacridine-1,8-diones and Xanthene-1,8-diones: Evaluation of their Biological Activity Curr. Org. Synth. (IF 1.8) Pub Date : 2023-12-14 Sandeep T. Atkore, Pranita V. Raithak, Kotra Vijay, Siddique Akber Ansari, Irfan Aamer Ansari, Ravi Varala
Background: Bimetallic catalysis plays a major role in boosting the catalytic performance of monometallic counterparts due to the synergetic effect. Materials and Methods: In the present study, we have exploited ZrCl4:Mg(ClO4)2 as an efficient bimetallic catalyst for the synthesis of a few biologically relevant N-substituted decahydroacri-dine-1,8-diones and xanthene-1,8-diones under solvent-free conditions
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The Second Omega Index Curr. Org. Synth. (IF 1.8) Pub Date : 2023-12-14 Nurten Urlu Ozalan, Ahmet Sinan Cevik, Ismail Naci Cangul
Background: The omega index has been recently introduced to identify a variety of topological and combinatorial aspects of a graph with a new viewpoint. As a continuing study of the omega index, by considering the incidence of edges and vertices to the adjacency of the vertices, in this paper, we have introduced the second omega index Ω2 and then computed it over some well-known graph classes. Methods:
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Anti-Inflammatory and Antimicrobial Potential of 1, 3, 4-Oxadiazoles and its Derivatives: A Review Curr. Org. Synth. (IF 1.8) Pub Date : 2023-12-01 Tarun Chaudhary, Prabhat Kumar Upadhyay, Ritu Kataria
:: 1, 3, 4-oxadiazole and its derivatives have significant anti-inflammatory and antimicrobial property. Their precise mechanism of action is not known but it is postulated that they act by inhibiting the biosynthesis of certain prostaglandins. 1, 3, 4-oxadiazoles are a class of heterocyclic compounds with wide variety of biological and pharmacological activities. They have been reported to possess
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Recent Advancements in the Synthesis of α-fluoroalkylated Azine-derived Heterocycles through Direct Fluorination Curr. Org. Synth. (IF 1.8) Pub Date : 2023-12-01 Oksana Shavrina, Yuliya Rassukana, Petro Onysko
:: The review highlights recent advancements in the synthesis of α-fluoro and α,α- difluoroalkylated azines, focusing on two main approaches. The first approach involves nucleophilic deoxofluorination, wherein α-hydroxy- or α-oxoalkylated azines are treated with diethylaminosulfur trifluoride or other S-F reagents to introduce fluorine atoms. The second approach employs direct electrophilic benzylic
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Synthesis, DPPH Radical Scavenging, Cytotoxic Activity, and Apoptosis Induction Efficacy of Novel Thiazoles and Bis-thiazoles Curr. Org. Synth. (IF 1.8) Pub Date : 2023-11-08 Amr Negm, Yasair S. Al-Faiyz, Sayed Riyadh, Abdelwahed R. Sayed
Background:: Heterocyclic materials-containing thiazoles exhibited incredible importance in pharmaceutical chemistry and drug design due to their extensive biological properties. Methods:: Synthesis of thiazoles and bis-thiazoles from the reaction of 2-((6-Nitrobenzo[ d][1,3]dioxol-5-yl)methylene)hydrazine-1-carbothioamide with hydrazonoyl chlorides in dioxane and in the existence of triethylamine
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Synthesis and Characterization of Novel pH-Responsive Aminated Alginate Derivatives Hydrogels for Tissue Engineering and Drug Delivery Curr. Org. Synth. (IF 1.8) Pub Date : 2023-11-06 Shokouh Khodayar, Mohammad Reza Shushizadeh, Elham Tahanpesar, Behzad Sharif Makhmalzadeh, Haleh Sanaeishoar
Aims: The aims of this study are to synthesize new derivatives of sodium alginate that improve the inherent properties, such as hydrogel strengthening, and create environmental sensitivity, such as pH sensitivity, for use in drug delivery. Background: Today, hydrogels, due to outstanding properties such as biodegradability, biocompatibility, mechanical properties, and response to stimuli properties
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Hybrids of Benzimidazole-Oxadiazole: A New Avenue for Synthesis, Phar-macological Activity and Recent Patents for the Development of More Ef-fective Ligands Curr. Org. Synth. (IF 1.8) Pub Date : 2023-11-02 Gunjan Bhasker, Salahuddin Salahuddin, Dr. Avijit Mazumder, Rajnish Kumar, Greesh Kumar, Mohamed Jawed Ahsan, Mohammad Shahar Yar, Fahad Khan, Bhupinder Kapoor
Background:: Two significant families of compounds i.e. 1,3,4-oxadiazole and ben-zimidazole, have undergone extensive investigation into their pharmacological characteristics and possible therapeutic applications. Both classes have shown their potential in a variety of ap-plications, and because of their synergistic interactions, they may have an even better therapeutic impact when combined. Objectives::
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Degree Descriptors and Graph Entropy Quantities of Zeolite ACO Curr. Org. Synth. (IF 1.8) Pub Date : 2023-10-26 Jia-Bao Liu, Micheal Arockiaraj, Daniel Paul, Joseph Clement, Xuemei Zhao, Sushil Tigga
Background: Cheminformatics is a fascinating emerging subfield of chemical graph theory that studies quantitative structure-activity and property relationships of molecules and, in turn, uses these to predict the physical and chemical properties, which are extremely useful in drug discovery and optimization. Knowledge discovery can be put to use in pharmaceutical data matching to help in finding promising
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Connection-Based Zagreb Indices of Polycyclic Aromatic Hydrocarbons Structures Curr. Org. Synth. (IF 1.8) Pub Date : 2023-10-23 Muhammad Usman, Muhammad Javaid
Background: Topological indices (TIs) are mathematical formulas that are applied in mathematical chemistry to predict the physical and chemical properties of various chemical structures. In this study, three different types of polycyclic aromatic hydrocarbon structures (PAHs) (i.e., Hexa-peri-hexabenzocoronene, Dodeca-benzo-circumcoronene, and Hexa-cata- hexabenzocoronene) are studied with the help
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Diverse Pharmacological Potential of different Substituted Pyrazole Derivatives Curr. Org. Synth. (IF 1.8) Pub Date : 2023-10-19 Mohammad Asif, Mazen M. Almehmadi, Ahad Alsaiari, Mamdouh Allahyani
: The chemistry of heterocyclic compounds has been a topic of research interest. Some five-membered heterocyclic compounds have been the subject of extensive research due to their different types of pharmacological effects. The five-membered nitrogen-containing heterocyclic compounds pyrazole, pyrazoline, and pyrazolone derivatives have a lot of interest in the fields of medical and agricultural chemistry
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Iodoxybenzoic Acid (IBX) in Organic Synthesis: A Septennial Review Curr. Org. Synth. (IF 1.8) Pub Date : 2023-10-19 Ravi Varala, Vittal Seema, Mohammed Mujahid Alam, Narsimhaswamy Dubasi, Rama Devi Vummadi
: Visible light-induced reactions are a rapidly developing and powerful technique to promote organic transformations. They provide green and sustainable chemistry and have recently received increasing attention from chemists due to their wide application in organic synthesis. Light energy is eco-friendly, cheap, green, and inexhaustible with potential industrial and pharmaceutical applications. In
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Omega Invariant of Complement Graphs and Nordhaus-Gaddum Type Results Curr. Org. Synth. (IF 1.8) Pub Date : 2023-10-05 Aysun Yurttas Gunes
The study aimed to obtain relationships between the omega invariants of a graph and its complement. We used some graph parameters, including the cyclomatic numbers, number of components, maximum number of components, order, and size of both graphs G and G. Also, we used triangular numbers to obtain our results related to the cyclomatic numbers and omega invariants of G and G. Several bounds for the
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One-pot Multicomponent Reaction: An Efficient Synthesis of 4-(Het)ArylSubstituted Pyrazolo-Quinolinones Curr. Org. Synth. (IF 1.8) Pub Date : 2023-10-04 Hüseyin Kerim Beker, Şeniz Kaban
Introduction: Pyrazolo-quinolinones (PQs) are a versatile class of Organic chemistry and it was found that they have very advanced functionally promising as selective compounds due to their scaffold and demonstrated low toxicity and considerable clinical promise. Moreover, these compounds have an important role in different applications such as analytical reagents, technical, pharmaceutical development
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Green Synthetic Methods of Oxazine and Thiazine Scaffolds as Promising Medicinal Compounds: A Mini-Review Curr. Org. Synth. (IF 1.8) Pub Date : 2023-10-02 Abdulelah Aljuaid, Mamdouh Allahyani, Ahad Amer Alsaiari, Mazen Almehmadi, Abdulaziz Alsharif, Mohammad Asif
: Medical researchers have paid close attention to the green synthesis of oxazine and thiazine derivatives since they provided a lead molecule for the creation of numerous possible bioactive compounds. This review provides more information on green synthesis, which will be very helpful to researchers in creating the most effective, affordable, and clinically significant thiazine and oxazine derivatives
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Design, Synthesis, QSAR studies, and Molecular Modeling of Some Novel Bis Methyl 2-[3-(benzo[d]thiazol-2-yl)-2-terephthaloyl-bis-4-oxo-thiazolidin-5-ylidene]acetates and Screening of their Antioxidant and Enzyme Inhibition Properties Curr. Org. Synth. (IF 1.8) Pub Date : 2023-09-06 Muhammad Naseem, Hummera Rafique, Muhammad Tayyab, Aamer Saeed, Amara Mumtaz
Introduction: Benzothiazolamine-based bisthiourea precursors were prepared in good yields. These bisthiourea derivatives were cyclized into symmetrical Bis Methyl 2-[3-(benzothiazol-2-yl)-2-terephthaloyl-bis-4-oxo-thiazolidin-5-ylidene]acetates, by their condensation with (DMAD) dimethyl but-2-meditate in the presence of dry methanol. Method: All these compounds were evaluated for their biological
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Synthesis, Characterization, DPPH Radical Scavenging, Urease Enzyme Inhibition, Molecular Docking Simulation, and DFT Analysis of Imine Derivatives of 4-formylpyridine with Selective Detection of Cu+2 Ions Curr. Org. Synth. (IF 1.8) Pub Date : 2023-09-04 Ambreen Zia, Syed Nawazish Ali, Erum Hasan, Mehreen Lateef, Syeda Rehana Zia, Sana Gul, Syeda Farah Bukhari, Nazish Dildar
This study aimed to prepare three imine derivatives (1, 2, and 3) via a condensation reac-tion of phenyl hydrazine, 2-hydrazino pyridine, and 4-methoxy aniline with 4-formyl pyridine. Electron impact mass spectrometry (EIMS), proton nuclear magnetic resonance (1H-NMR), ultraviolet-visible (UV-Vis) and Fourier transform infrared (FTIR) spectroscopy were utilized for the characterization. The chemosensing
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Green Approach Toward Triazole Forming Reactions for Developing Anticancer Drugs Curr. Org. Synth. (IF 1.8) Pub Date : 2023-09-04 Shiva K. Rastogi, Veronica C. Ciliberto, Monica Z. Trevino, Brooke A. Campbell, William J. Brittain
Compounds containing triazole have many significant applications in the dye and ink industry, corrosion inhibitors, polymers, and pharmaceutical industries. These compounds possess many antimicrobial, antioxidant, anticancer, antiviral, anti-HIV, antitubercular, and anticancer ac-tivities. Several synthetic methods have been reported for reducing time, minimizing synthetic steps, and utilizing less
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Scale-up of Sodium Persulfate Mediated, Nitroxide Catalyzed Oxidative Functionalization Reactions Curr. Org. Synth. (IF 1.8) Pub Date : 2023-09-01 Katrina E. Doherty, Arturo León Sandoval, Fabrizio Politano, Mason L. Witko, Chelsea M. Schroeder, William P. Brydon, Geoffrey P. Wadey, Kristiane K. Ohlhorst, Nicholas E. Leadbeater
Background: Oxidation is a valuable tool in preparative organic chemistry. Oxoammonium salts and nitroxides have proven valuable as reagents and catalysts in this endeavor. Objective: The objective of this study is to scale up the oxidative amidation, ester formation, and nitrile formation using nitroxide as an organocatalyst. Methods: Oxidative functionalization reactions were scaled from the 1 mmol
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Computing the Energy of Certain Graphs based on Vertex Status Curr. Org. Synth. (IF 1.8) Pub Date : 2023-09-01 Asim Khurshid, Muhammad Salman
Background: The concept of Hückel molecular orbital theory is used to compute the graph energy numerically and graphically on the base of the status of a vertex. Objective: Our aim is to explore the graph energy of various graph families on the base of the status adjacency matrix and its Laplacian version. Methods: We opt for the technique of finding eigenvalues of adjacency and Laplacian matrices
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A Recent Update on the Visible Light-promoted Organic Transformations - A Mini-review Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-29 Monica Dinodia
: Visible light-induced reactions are a rapidly developing and powerful technique to promote organic transformations. They provide green and sustainable chemistry and have recently received increasing attention from chemists due to their wide application in organic synthesis. Light energy is eco-friendly, cheap, green, and inexhaustible with potential industrial and pharmaceutical applications. In
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Functionalized Morpholine-thiazole Scaffold: Synthetic Strategies and Applications Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-28 Tarik E. Ali, Mohammed A. Assiri, Maha N. Alqahtani
The thiazole derivatives as important members of heterocyclic compounds have attracted much synthetic interest due to their different biological properties. In recent years, studies on the syn-thesis of morpholine compounds have increased because of the properties of this core. In particular, the hybrid structures in which the thiazole ring is linked to morpholine nuclei in one molecular frame have
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Tetra-azolium salts induce significant cytotoxicity in human colon cancer cells, in vitro Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-25 Muhammad Adnan Iqbal, Muhammad Ashraf, Amna Kamal, Ejaz Ahmed, Haq Nawaz Bhatti, Muhammad Arshad
Background: Azolium salts are the organic salts used as stable precursors for generating N-Heterocyclic Carbenes and their metal complexes. Azolium salts have also been reported to have significant biological potential. Hence, in the current study, four tetra-dentate azolium salts were derived from bis-azolium salts by a new synthetic strategy. Methods: The tetra azolium salts have been synthesized
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Pyrazoline and Analogs: Substrate-Based Synthetic Strategies Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-23 Himanshu Singh, Rajnish Kumar, Avijit Mazumder
: Among the many reports published on strategies applicable to synthesizing pyrazolines and its analogs, The 1,3-dipolar cycloaddition offers a remarkably wide range of utility. Many 1,3-dipolar cycloaddition reactions used for the synthesis of pyrazolines provide better selectivity, eco-friendly, and less expensive chemical processes. In the presented study, we have reviewed various recently adopted
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A one-pot synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic acid and DMF derivatives using imidazole hydrochloride as a promoter Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-15 Jianyong Yuan, Yin Wang, Xiuyu Zhang, Suzhen Li, Mengyi Guo, Wanqian Ma
: As a novel and environmentally friendly Brönsted acid, imidazole hydrochloride was used to promote the synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic acid and DMF derivatives. The essence of this reaction is a multicomponent reaction, which constructs multiple chemical bonds between different components through the transamidation of imidazole hydrochloride. This protocol showed
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Synthesis, Antimicrobial and Antioxidant Activity of some New Pyrazolines Containing Azo Linkages Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-15 Awaz Jamil Hussein
Background: Pyrazolines and azo-pyrazolines are influential groups of heterocyclic compounds with two nitrogen atoms inside the five-membered ring. They play an important role in a wide range of biological processes, such as antifungal, antioxidant, antimalarial and other antimicrobial activities. Objective: The main objective of this study is to synthesize some new heterocyclic compounds with antioxidant
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Pictet-Spengler Synthesis of N-heteroaromatics Extended Porphyrins Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-15 Dileep Kumar Singh
Background: Porphyrins are highly conjugated heterocyclic compounds and are found as the backbone of many natural products such as heme and chlorophyll. To improve its biological and optical properties, the functionalization of porphyrin at its β- and meso-position has gained importance in recent years. Objective: The purpose of this review is to describe the Pictet-Spengler method for the incorporation
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New Relations between Zagreb Indices and Omega Invariant Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-10 Aysun Yurttas Gunes
In this work, we studied the problem of determining the values of the Zagreb indices of all the realizations of a given degree sequence. Methods: We first obtained some new relations between the first and second Zagreb indices and the forgotten index sometimes called the third Zagreb index. These relations also include the triangular numbers, order, size, and the biggest vertex degree of a given graph
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Synthesis and Molecular Docking Study of Some New Thiazole-coumarin Molecular Hybrids as Antibacterial Agents Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-09 Jehan Y. Al-Humaidi, Sobhi M. Gomha, Fathy M. Abdelrazek, Hassan M. Abdel-aziz, Aboubakr H. Abdelmonsef
Background: The emergence of drug-resistant bacteria and multidrug-resistant diseases, both of which are associated with high mortality, has posed a serious global health issue. Thiazoles and coumarins were reported as antimicrobial agents. Objective: This research paper aims to describe the synthesis of some novel thiazole derivatives bearing a coumarin residue as antibacterial agents Methods: The
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Zagreb Topological Properties of Hexa Organic Molecular Structures Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-04 Javaria Iqbal, Muhammad Salman
Background: In connection with the study of chemical graph theory, it has been explored that a single number can capture the numerical representation of a molecular structure, and this number is known as a topological property (index). Objective: This study aimed to explore a few Zagreb topological properties for four hexa organic molecular structures (hexagonal, honeycomb, silicate, and oxide) based
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Pyrene Appendant Triazole-based Chemosensors for Sensing Applications Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-04 Tarkeshwar Maddeshiya, Manoj Kumar Jaiswal, Arpna Tamrakar, Gargi Mishra, Chhama Awasthi, Mrituanjay D. Pandey
Over the last two decades, the design and development of fluorescent chemosensors for the targeted detection of Heavy Transition-metal (HTM) ions, anions, and biological ana-lytes, have drawn much interest. Since the introduction of click chemistry in 2001, triazole moie-ties have become an increasingly prominent theme in chemosensors. Triazoles generated via click reactions are crucial for sensing
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Study of Different Types of Fermentation in Wine-Making Process and Considering Aromatic Substances and Organic Acid Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-03 Mohamad Hesam Shahrajabian, Wenli Sun
: Fermentation is being utilized since ages as a safe process for food preservation. Fermentation in winemaking is the process which converts grapes juice into wine. Alcoholic fermentation is the principle for the manufacturing of alcoholic beverages like wine and beer. Several by-products are produced by the alcoholic fermentation of organic carbon sources by Saccharomyces cerevisiae. The secondary
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Forgotten Topological and Wiener Indices of Prime Ideal Sum Graph of Zn Curr. Org. Synth. (IF 1.8) Pub Date : 2023-08-01 Esra Öztürk Sözen, Elif Eryaşar, Cihat Abdioğlu
Background: Chemical graph theory is a sub-branch of mathematical chemistry, assuming each atom of a molecule is a vertex and each bond between atoms as an edge. Objective: Owing to this theory, it is possible to avoid the difficulties of chemical analysis because many of the chemical properties of molecules can be determined and analyzed via topological indices. Due to these parameters, it is possible
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Investigation of the Dyeing Ability of Some Reactive Triazine Azo Dyes Containing Pyrazole Fragment Curr. Org. Synth. (IF 1.8) Pub Date : 2023-07-17 Alaa Z. Omar, Mohamed G. Mohamed, Ezzat A. Hamed, Mohamed A. El-atawy
A series of reactive disperse dyes bearing azo and cyanuric groups were synthesized, and their structures were established using spectral and elemental analyses. Methods: The IR, 1H NMR, and DFT studies indicated that the prepared reactive disperse dyes predominately exist as hydrazone tautomers. The electronic absorption spectra in methanol were observed and compared to those computed using B3LYP/6-311G(d
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Transition Metals Catalyzed Direct C-H Chalcogentaion of Arenes and Heteroarenes Curr. Org. Synth. (IF 1.8) Pub Date : 2023-07-13 Atanu Mahata, Madhusudan Garain, Totan Roy, Dilip Gorai, Debasish Kundu
Transition metals catalyzed C-H bond activation reactions have appeared as an emerging field to introduce different functional groups in the inactivated saturated and unsaturated C-H bonds. C-S and C-Se bond constructions in aromatic scaffolds are very interesting due to the important applications of organochalcogen reagents in pharmaceutical chemistry and the material world. The introduction of sulphur
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Triazole-linked Nucleic Acids: Synthesis, Therapeutics and Synthetic Biology Applications Curr. Org. Synth. (IF 1.8) Pub Date : 2023-07-12 Vivek K. Sharma, Priyanka Mangla, Sunil K. Singh, Ashok K. Prasad
This article covers the triazole-linked nucleic acids where the triazole linkage (TL) replaces the natural phosphate backbone. The replacement is done at either a few selected linkages or all the phosphate linkages. Two triazole linkages, the four-atom TL1 and the six-atom TL2, have been discussed in detail. These triazole-modified oligonucleotides have found a wide range of applications, from therapeutics
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Recent Advancement in Multicomponent Synthesis of Fused Coumarin Derivatives Curr. Org. Synth. (IF 1.8) Pub Date : 2023-07-07 Vinita Yadav, Ajay Thakur, Ruchi Bharti, Monika Verma, Renu Sharma
The synthesis of coumarin derivatives has been an essential topic since its discovery in 1820. In bioactive compounds, the coumarin moiety serves as a backbone, as many such bioactive compounds with the coumarin moiety play a significant role in their bioactivities. Given this moie-ty's relevance, several researchers are developing fused-coumarin derivatives to create new drugs. Mostly the approach
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An Overview of Julia-lythgoe Olefination Curr. Org. Synth. (IF 1.8) Pub Date : 2023-07-06 Vijayan Varsha, Sankaran Radhika, Gopinathan Anilkumar
Julia-Lythgoe olefination (or simply Julia olefination) is an olefination process between phenyl sulfones and aldehydes (or ketones) to give alkenes after alcohol functionalization and re-ductive elimination using sodium amalgam or SmI2. It is mainly used to synthesize E-alkenes and is a key step in numerous total syntheses of many natural products. This review exclusively deals with the Julia-Lythgoe
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Synthesis and Cytotoxic Activity of Quinazoline-Benzofuran Conjugates Curr. Org. Synth. (IF 1.8) Pub Date : 2023-06-26 Chunping Wan, Zewei Mao, Yixin Liu, Nanting Zou, Minxin Li
Aims: In order to study on structure-activity relationships of benzofurans. Background: Benzofuran is a kind of natural compound widely existing in nature with pharmacological effects. The development of new anticancer benzofuran derivatives has attracted more and more attention. Method: We have introduced an active quinazoline unit into piperazine-substituted benzofuran, prepared a series of quinazoline-benzofuran
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Free Salt Dyeing by Treatment of Cotton Fabric Using Carboxyethyl Chitosan and Synthesized Direct Dyes to Enhance Dyeing Properties and Antibacterial Activity Curr. Org. Synth. (IF 1.8) Pub Date : 2023-06-23 Wafa Abdullah I. Al-Megrin, Manal F. El-khadragy, Fatma A. Mohamed, Hassan M. Ibrahim
Aim: The purpose of this paper is to synthesize and characterize two new direct dyes based on chromenes derivatives. Background: The synthesis of carboxyethyl chitosan (CECS) by the reaction of chitosan and acrylic acid via Michael's addition reaction was conducted. Cotton fabrics were treated with CECS to enhance the exhaustion of dye, fastness properties, and antimicrobial activity of dyed fabric
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Catalytic One-pot Solvent Free Synthesis, Biological Activity, and Docking Study of New Series of 1, 3-thiazolidine-4-one Derivatives Derived from 2-(P-tolyl) Benzoxazol-5-amine Curr. Org. Synth. (IF 1.8) Pub Date : 2023-06-23 Hussein Kaka Ahmed Khudhur, Awaz Jamil Hussein
Objective: In this study, a simple triethylammonium salt of phosphoric acid (tri-ethylammonium dihydrogen phosphate) (4) in the liquid state was utilized as an inexpensive, efficient one-pot three components, solvent-free synthesis of thiazolidine-4-one derivatives, with good to excellent yields. Techniques such as FT-IR, 1H-NMR, 13C-NMR, 13C-NMR-DEPT-135, and MS. were used for the structural elucidation
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Synthesis of Novel Fluoro Phenyl Triazoles Via Click Chemistry with or without Microwave Irradiation and their Evaluation as Anti-proliferative Agents in SiHa Cells Curr. Org. Synth. (IF 1.8) Pub Date : 2023-06-23 Johana Aguilar, Elisa Leyva, Silvia Elena Loredo-Carrillo, Agobardo Cárdenas-Chaparro, Antonio Martínez-Richa, Hiram Hernández-López, Jorge Gustavo Araujo-Huitrado, Angélica Judith Granados-López, Yamilé López-Hernández, Jesús Adrián López
Aims: Perform the synthesis of novel fluoro phenyl triazoles via click chemistry with or without microwave irradiation and their evaluation as anti-proliferative agents in SiHa cells Background: Triazoles are heterocyclic compounds containing a five-member ring with two carbon and three nitrogen atoms. They are of great importance since many of them have shown to have biological activity as antifungal
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Recent Progress on Synthesis of Functionalized 1,5-Disubstituted Triazoles Curr. Org. Synth. (IF 1.8) Pub Date : 2023-06-23 Manoj K. Jaiswal, Abhishek Gupta, Faisal J. Ansari, Vinay K. Pandey, Vinod K. Tiwari
Immediately after the invention of ‘Click Chemistry’ in 2002, the regioselective 1,2,3-triazole scaffolds resulted from respective organic azides and terminal alkynes under Cu(I) cataly-sis have been well recognized as the functional heterocyclic core at the centre of modern organic chemistry, medicinal chemistry, and material sciences. This CuAAC reaction has several notable features including excellent