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Valorisation of olive pomace: phenolic prospecting and biological potential Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-27 Bruna Wendt Böhmer-Maas, Deborah Murowaniecki Otero, Pâmela Inchauspe Corrêa Alves, Nathalia Stark Pedra, Marjana Radünz, Eliézer Ávila Gandra, Rui Carlos Zambiazi
Phenolic compounds were extracted from biphasic olive pomace and their biological potential was characterised. Two different extracts were prepared, E1 (40% methanol) and E2 (80% methanol), both su...
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Highly selective alkylcoumarates and diterpenoids isolated from leaves of Baccharis quitensis: a search for new hit compounds against Trypanosoma cruzi Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-27 Nathalia Peres, Matheus L. Silva, Anderson K. Ueno, Guilherme M. Antar, Erica V. C. Levatti, Andre G. Tempone, João Henrique G. Lago
In the present work, the hexane extract of aerial parts of Baccharis quitensis Kunth. was subjected to chromatographic fractionation to afford two alkyl phenylpropanoids: n-docosyl (E)-p-coumarate ...
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Extraction and detection of mitragynine in Kratom leaves by high-performance liquid chromatography Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-27 Karno Ng, Taehoon Ha
Mitragyna speciosa, also known as Kratom, is an evergreen tree native to Southeast Asia that has been used in traditional medicine to relieve pain. The primary active alkaloid, mitragynine, found i...
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Combination of tenuigenin-based Polygala tenuifolia willd. root extract and forsythoside a improved Alzheimer’s disease Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-26 Guocui Liang, Chengxia Gao, Liwei Zhang, Huizhi Du
Tenuigenin is a kind of the main active ingredients in roots of Polygala tenuifolia Willd. (a species in the genus Polygala, family Polygalaceae) and forsythoside A (FA) is one of the main active i...
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Isolation of two peptaibols with potent antimicrobial and cytotoxic activities from the mangrove endophytic fungus Trichoderma lentiforme ML-P8-2 Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-27 Yihao Yin, Ge Zhu, Jianying Wu, Zhigang She, Jie Yuan, Bo Wang
Trichorzin PA is a family of 18-residue peptaibols with linear and flexible peptide chains. The three-dimensional structures and biological activities of trichorzin PA peptaibols are largely unchar...
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Genetic activity and cytotoxic effect of Silybum marianum extract in comparison with the impact of antitumor drugs etoposide and methotrexate: a study on Drosophila melanogaster Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-27 Olga Nikolaevna Antosyuk, Elena Aleksandrovna Sharova, Anastasiya Konstantinovna Verbitskaya
One of the most important directions in medical practice involves the exploration of protectors and adaptogens to mitigate side effects associated with the use of antitumor and potent medications. ...
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Isolation, purification and structure elucidation of eight saponin compounds from Calotropis gigantea Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-27 Sudha Kulkarni, Ajit Gaikwad, Nilesh Bhoi, Amit Hade, Mona Kokwar, Manali Gulwade
Identifying the active ingredient from plant extracts and establishing its safety and efficacy remains a challenge, so there is need to develop optimised Isolation and purification method to concen...
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Ethnomedical uses, biocompounds and biological properties of Cereus Jamacaru DC. (Cactaceae): a comprehensive review Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-27 Leila Magda Rodrigues Almeida, Luzimar Gonzaga Fernandez
Cereus jamacaru, popularly known as mandacaru, is a Cacactacea native to the Caatinga of Brazil, but it is distributed in arid and semiarid regions worldwide. This plant is used for various purpose...
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Analysis of metabolic compounds and antitumorigenic effects of Albizia niopoides and Senegalia polyphylla leaves Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-26 Thalissa Cagnin Pereira, Luana Pereira Cardoso, Wesller da Silva de Paiva, Liliane Santos de Camargos, Flávia Cristina Rodrigues-Lisoni, Aline Redondo Martins
The objective of this study was to quantify metabolic compounds in leaves of A. niopoides and S. polyphylla and to evaluate the antitumor potential of extracts from both species in cervical tumour ...
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Synthesis and antifungal activity of hexahydropyrrolidoindole alkaloids Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-26 Yujie Zhou, Shoude Ma, Xiaohan Li, Xinye Liu, Jie Gao, Dingding Lü, Ya Wang, Shaojun Zheng
Twenty-one hexahydropyrrolidoindole alkaloids were designed and synthesised via acylation reaction at the 3-N position from the commercially available indole-3-acetonitrile as the starting material...
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Endophytic fungus from Gynura japonica: phytochemical screening, biological activities, and characterisation of its bioactive compound Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-26 Riga Riga, Ridha Wardatillah, Okta Suryani, Benny Ryplida, Suryelita Suryelita, Minda Azhar, Dian Handayani, Muh. Ade Artasasta, Sonni Maurit Benu, Ahadul Putra
The research aims to identify the chemical constituents of endophytic fungi associated with Gynura japonica and their biological activities. Two endophytic fungi, labelled as GS-1 and GS-2, have be...
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A new cucurbitane − type triterpenoid from the bark of Elaeocarpus hygrophilus Kurz. Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-23 Thi-Ngoc-Nuong Nguyen, Thi-Nga Vo, Kim-Phi-Phung Nguyen, Tri-Hieu Nguyen, Thi-Anh-Tuyet Nguyen
A new cucurbitacin, 3β-(β-D-glucopyranosyloxy)-5β,6β:16α,23α-diepoxycucurbit-24-en-11-one or hygrocucurbin A (1), along with two known compounds, including 3β-(β-D-glucopyranosyloxy)-16α,23α-epoxyc...
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Antiviral and cytotoxic indole diterpenoids from the antarctic sponge-derived fungus Aspergillus candidus HDN15-152 Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-25 Bingying Tang, Runfang Zhang, Falei Zhang, Tianjiao Zhu, Qian Che, Dehai Li, Guojian Zhang
One new indole diterpenoid, ascandinine T (1), and three known analogues (2–4) were isolated from an Antarctic sponge-derived fungus Aspergillus candidus HDN15-152. The structures, including absolu...
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Fructose-induced hyperuricaemia – protection factor or oxidative stress promoter? Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-24 Amelia Tero-Vescan, Ruxandra Ștefănescu, Tudor-Ionuț Istrate, Amalia Pușcaș
Accumulating evidence suggests that dietary fructose may play a role in the hyperuricaemia development, but the precise mechanism remains unclear. Hyperuricaemia is characterised by excessive produ...
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Molecular docking of quercetin: a promising approach for the development of new anti-inflammatory and analgesic drugs Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-23 Amina Ettitaou, Hamid Kabdy, Khadija Oubella, Karima Raoui, Mehdi Oubahmane, Rachida Aboufatima, Loubna Elyazouli, Stefania Garzoli, Abderrahman Chait
The aim of this study is to investigate the antinociceptive, anti-inflammatory and antipyretic effects of quercetin. Additionally, molecular docking studies were conducted to evaluate potential int...
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A new phenolic compound from Persicaria capitata Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-23 Lei He, Fei Zhong, Xing-Jun Chen, Ya-Ru Yang, Xue-Long Yan, Ming-Hui He, Xu Zhang, Mu-Zhen Wang, Yong-Qin Zeng, Qin-Feng Zhu, Zhu Zeng, Bo Tu, Qing-De Long, Yan Lin
Persicaria capitata was a frequently used Hmong medicinal flora in China. In this study, one new phenolic compound, capitaone A (1) together with 20 known ones, were isolated from the whole herb of...
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Development and synthesis of a novel salen-type ligand based on phenylalanine for Mizoroki-Heck, and S-arylation cross-coupling reactions Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-23 Bahnood Salmani Nezhad, Azizollah Habibi, Ahmad Takallou, Elham Badali, Satya Kumar Avula, Ahmed Al-Harrasi
In this article, we introduced a novel salen-type ligand precursor and applied it in the Pd-catalyzed Mizoroki–Heck and Cu-catalyzed S-arylation cross-coupling reactions. For the preparation of thi...
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A new sesquiterpene coumarins from Ferula bungeana Kitagawa Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-23 Xiurong Kang, Lili Wu, Chaoliang Zhao, Chaolumeng Zhang, Qinghu Wang
A new sesquiterpene coumarin, bungeanin A (1), together with four known sesquiterpene coumarins, were isolated from the whole plants of Ferula bungeana Kitagawa. The structure of bungeanin A was el...
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Impacts of microwave-assisted extraction parameters on total phenolic compounds yield from Algerian Moringa oleifera leaves, using response surface methodology Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-23 Farida Kheyar, Naoual Kheyar, Malek Amiali, Lila Boulekbache-Makhlouf, Ahcene Kadi, Ahmed Benchabane, Arezki Bitam
The study aimed to optimise the microwave-assisted extraction (MAE) of total phenolic compounds (TPC) from Moringa oleifera Lam. leaves using response surface methodology (RSM) and Box-Behnken desi...
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Peracetylation transforms natural products beyond mere derivatization Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-22 Ambili Sasikumar Athira, Balan Abhijith, M. V. Reshma, Ravi S. Lankalapalli
Peracetylation of the methanolic extract of Benincasa hispida led to the isolation of a compound with a peracetylated hex-4-en-3-one backbone. Mechanistic insights revealed that the isolated compou...
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Molecular docking and molecular dynamic simulation-based phytoconstituents against SARS-CoV-2 with dual inhibition of the primary protease targets Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-22 Sachin A. Dhawale, Sadhana Mahajan, Madhuri Pandit, Sachin Gawale, Mangesh Ghodke, Ganesh Tapadiya
A novel coronavirus has caused major health problems and is spreading globally. The main protease enzyme plays a significant role in the number of copies of ss-RNA produced during the proteolytic c...
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Antimicrobial phytoconstituents from Azadirachta indica (neem) with potential inhibitor against FtsZ protein of Pseudomonas aeruginosa Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-22 Mauricio E. Orozco-Ugarriza, Nicole Paola Arrieta Caldera, Yenifer Olivo-Martínez
Pseudomonas aeruginosa is a well-known pathogen for its rapid development of multi-drug antibiotic resistance. This pathogen is responsible for numerous human diseases, particularly affecting immun...
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Comtrifosides A and B, two new triterpenoid saponins from the leaves of Combretum trifoliatum Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-22 Cong Thai Son Nguyen, Thanh Hoa Vo, Nguyen Kim Tuyen Pham, Bui Linh Chi Huynh, Trong Nghia Ngo, Van Son Dang, Thi Kim Chi Huynh, Trong Dat Bui, Diep Xuan Ky Nguyen, Nhat Minh Phan, Dinh Tri Mai, Kim Phi Phung Nguyen, Tan Phat Nguyen
The phytochemical composition of the Combretum trifoliatum leaves was studied for the first time. Two new triterpenoid saponins, named comtrifoside A (1) and comtrifoside B (2), together with two o...
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Trans-cinnamaldehyde fumigation inhibits Escherichia coli by affecting the mechanism of intracellular biological macromolecules Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-22 Yuqiang Huang, Tong Zhang, Huiying Hu, Xuejuan Duan, Kegang Wu, Xianghua Chai, Dong He
This study aimed to determine the antibacterial mechanism of cinnamaldehyde fumigation in Escherichia coli (E. coli). Through vapour fumigation, cinnamaldehyde was confirmed to exhibit effective an...
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A new bufadienolide from Bufo gargarizans Cantor Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-22 Li-Jie Zhu, Li-Man Qiao, Jian Wu, Zhong-Hua Wang, Xiao-Jing Ye
Bufo gargarizans Cantor (B. gargarizans) is the most widely distributed and abundant species of toad in China. Bufadienolides and indole alkaloids have cardiotonic and anti-tumor activities and are...
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Spermacosides a and B, two new triterpenoid saponins from Spermacoce ocymoides burm.f. Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-22 Ngoc-Dung Nguyen, Thi-Nga Vo, Thi-Hong-Nhung Nguyen, Thi-Ngoc-Nuong Nguyen, Ngọc-Tin Nguyen, Kim-Phi-Phung Nguyen, Thi-Anh-Tuyet Nguyen
Two new triterpenoid saponins, named spermacosides A–B (1 − 2), together with two known oleanane-type triterpenoid saponins, 3-O-β-D-xylopyranosyl-(1→3)-β-D-glucopyranosylbayogenin (3) and 3-O-β-D-...
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Comparative antioxidant analysis of extracts prepared from Indigofera longiracemosa aerial parts identifies leaf methanolic extract as a promising antioxidant Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-22 Aswathy Chankaramkandath Vasu, Sheeja Tharakan, Suraj Kadunganattil
Extraction of phytochemicals from the leaves and stems of Indigofera longiracemosa, a previously underexplored dye-yielding plant, was done using four solvents of increasing polarity followed by in...
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Identification and bioactivity evaluation of ring-opening and lactone forms of enterolactone from sheep fed flaxseed cake Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-21 Cong-Cong Zhuang, Chun-Rui Liu, Hai-Yan Xu, Xin-Yue Yang, Dan-Dan Wu, Zhong Zheng, Li-Wei Wang, Zheng Liu, Chao-Mei Ma
The previously undescribed lactone ring-opening enterolactone and its sulphate were purified along with the lactone counterparts from the urine of dairy sheep fed flaxseed cake. The structures were...
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Two new megastigmane glycosides from the leaves of Nicotiana tabacum and their anti-inflammatory activities Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-19 Peng-fei Yang, Wei Wu, Hang-hang Han, Qing-fu Wang, Lei Li, Ze-ning Wang, Duo-bin Mao, Zhi-fei Chen
Two new megastigmane glycosides, (6 R,7E,9R)-3-oxo-α-ionyl-9-O-α-L-rhamnopyranosyl-(1′′→4′)-β-D-glucopyranoside (1) and (6 R,7E,9R)-3-oxo-α-ionyl-9-O-β-D-glucopyranosyl-(1′′→6′)-β-D-glucopyranoside...
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Chemodiversity essential oil from three species of Croton (Euphorbiaceae) and assessment of antimicrobial potential Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-20 Aldino N. Venancio, Otávio P. Araujo, Armanda A. Júlio, Gustavo R. Souza, Viviane M. Pereira, Isabella C. Teixeira, Mario F. Conceição Santos, Luciana A. Parreira, Luciano Menini
The Croton genus is known for its various biological properties, which inspired this study to investigate the anti-bacterial properties and chemodiversity of the essential oils of three Croton spe...
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A lupeol derivative and other isolates with antiplasmodial activity from the stem root of Rauvolfia mannii Stapf. (Apocynaceae) Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-18 Fred Alain Zoua, Daniela Ntomi Djipmegne, Mc Jésus Kinyok, Auguste Abouem A. Zintchem, André Néhémie Bitombo, Rostanie Dongmo Zeukang, Solenn Ferron, Dominique Serge Ngono Bikobo, Sophie Tomasi, Dieudonné Emmanuel Pegnyemb
Rauvolfia mannii is a plant from western and eastern areas of African continent and is widely used in folk medicine for the treatment of various diseases including malaria. Herein, one previously u...
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Management potentiality of emulsions based on essential oil of Piper macedoi and Piper arboreum for spider mite: a possible alternative for agroecological control Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-20 Kíssila França Lima, Victor Dias Pirovani, Luciana Alves Parreira, Mario Ferreira Conceição Santos, Karla Maria Pedra de Abreu, Luciano Menini
Tetranychus urticae, popularly known as spider mite, is a pest that causes several economic losses to crops. Thus, this work evaluated the effect of essential oils from the leaves of Piper macedoi ...
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Effect of saline stress on the metabolic profile and antidiabetic potential of Physalis peruviana Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-19 Nayely González-Buenrostro, Iza F. Pérez-Ramírez, Ofelia Mora, Alejandro Rios-Lozano, Ma Estela Vázquez-Barrios, Rosalía Reynoso-Camacho, Marely G. Figueroa-Pérez
Goldenberry is a fruit widely utilised for treating diabetes. Its nutraceutical properties can be enhanced by subjecting it to saline stress during cultivation. This study aimed to evaluate the eff...
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High perillaldehyde content from essential oils of Ammodaucus leucotrichus subsp. leucotrichus Cosson & Durieu fruits from Aougrout (Algeria) Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-19 Zineb Louail, Nadjette Djemouai, Karima Bouti, Hassina Tounsi, Abdelkrim Kameli
The chemical composition of the essential oil produced by hydrodistillation from the fruits of Ammodaucus leucotrichus subsp. leucotrichus Cosson & Durieu collected from southern Algeria, precisely...
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Design, synthesis and anti-oomycete activity of 2-acyloxyhinokitiol derivatives Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-19 Ruxue Wei, Yibo Liu, Wanying Yin, Ruiguang Wang, Yuee Tian, Xiaobo Huang, Le Qian, Shengming Liu, Genqiang Chen, Zhiping Che
In order to explore novel natural product-based anti-oomycete agent, ten 2-acyloxyhinokitiol derivatives (5a–j) were designed and synthesised, and structurally confirmed by 1H NMR,13C NMR, HRMS, an...
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Bioactive cholinesterase inhibitions of clerodanes from the flowers of Croton krabas and molecular docking studies Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-19 Oue-artorn Limtragool, Siripit Pitchuanchom, Chantana Boonyarat, Kwanjai Kanokmedhakul, Somdej Kanokmedhakul
The first investigation of the phytochemical profile of the flowers of Croton krabas led to the isolation of two new clerodane diterpenes, 6S-crotocaudin (1) and crotocaudin B (2), together with tw...
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A new labdane diterpenoid, in vitro and in silico cytotoxicity, and protease inhibitory effects of phytochemicals from Juniperus polycarposK. Koch leaves Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-19 Moslem Naderian, Salar Hafez Ghoran, Muhammad Ikhlas Abdjan, Zahra Sabahi, Soheila Moein, Amir Reza Jassbi, Mahmoodreza Moein
Cytotoxicity-guided purification of Juniperus polycarpos K. Koch leaves (Cupressaceae) led to the isolation of a new labdane diterpenoid, 3-(acetyloxy)-acetylisocupressic acid (1), together with is...
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Steroidal saponins and homoisoflavonoids from the fibrous roots of ophiopogon japonicus and their anti-pulmonary fibrosis activities Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-18 Hang-Yi Pu, Yu Cao, Xi-Lang Jiang, Lin-Han Yang, Ming-Kui Wang, Fei Wang, Lun Wang
The chemical investigation of the fibrous roots of Ophiopogon japonicus afforded two new steroidal saponins, named ophiojaponin F (1) and ophiojaponin G (2), together with twelve known steroidal sa...
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The chemical composition of the aerial parts’ essential oil of matthiola fruticulosa (L.) maire growing in Sicily, Italy Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-18 Natale Badalamenti, Alessandro Vaglica, Antonella Porrello, Vincenzo Ilardi, Maurizio Bruno
Matthiola Aiton is a genus belonging to the Brassicaceae family, distributed in Macaronesia, the Mediterranean basin, and the Saharo-Sindian region. Plants of this genus are used against various di...
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Flavonoids, biphenyls and xanthones from the genus Clusia: chemistry, biological activities and chemophenetics relevance Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-18 Ismirna I. P. dos Santos, Maria do Carmo C. Silva, Caline G. Ferraz, Paulo R. Ribeiro
Clusia is one of the most important genera of the Clusiaceae family, comprising up to 400 species. This review describes the identification of twenty-two flavonoids from Clusia species, which inclu...
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Multiple integrated computational approach to analyse wound healing potential of Symplocos racemosa bark as Matrix metalloproteinase inhibitors Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-18 Hafiz Abdul Rafey, Adnan Amin, Samir Anis Ross, Mohamed El-Shazly, Muhammad Ammar Zahid, Shah Iram Niaz, Fakhar Ul Mahmood, Hammad Ullah
The healing of wounds is the flagging concern in chronic wound cases especially when accompanied by pathogenic, diabetic comorbidities. Matrix metalloproteinases are associated with widespread path...
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Could lactose-free foods influence the gut microbiome? Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-18 Eleonora Di Salvo, Nicola Cicero
Published in Natural Product Research: Formerly Natural Product Letters (Ahead of Print, 2024)
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Effect of Gracilaria changii extract and its fraction in reverse cholesterol transport by targeting SR-BI gene Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-14 Mohd Rahaizuddin Rani, Ahmad Khusairi Azemi, Kamariah Bakar, Luqman Abu-Bakar, Tengku Sifzizul Tengku Muhammad, Noraznawati Ismail
This present study aimed to investigate the effects of Gracilaria changii (Red seaweed) extract and its fraction on scavenger receptor class B type I (SR-BI) gene expressions. In vitro studies of t...
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Anti-vibriosis bioactive molecules from marine-derived variant Streptomyces sp. ZZ741A Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-14 Di Zhang, Yao Feng, Mingyi Chu, Yujiang Dai, Lu Jiang, Huifang Li
The infection of vibrio is an important cause of huge economic losses in aquaculture industry. At present, antibiotics are mainly used to prevent and reduce the infection of the vibrio, which has a...
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Two novel ketone alkaloids from Portulaca oleraceaL. and their anti-inflammatory activities Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-12 Hongzhe Zhang, Jing Liu, Junjie Yao, Fan He, Xixiang Ying
Eleven compounds were obtained from Portulaca oleracea L., including two novel ketone alkaloids, (1, 2), 4-hydroxy-3-methoxybenzamide (3) (isolated for the first time), β-adenosine (4), oleracrylim...
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Separation of crude methanol extract of Plantago major root: identification of phytochemicals and assessment of biological activities Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-12 Samaneh Rahamouz-Haghighi, Ali Sharafi
Plantago major root extracts were used for analysis by Gas Chromatography-Mass Spectrometry (GC-MS). The anticancer and antibacterial functions of extracts were also investigated. The dichlorometha...
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Pharmacognostic standardization and evaluation of antiulcer potential of Olax psittacorum leaf extract Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-10 Pragyan Parimita Mansingh, Lopamudra Adhikari, Moonmun Dhara
The modern medicine has received many plants as a gift from ethnobotany. It is an efficient method of discovering new medicines. The leaves of Olax psittacorum (Lam.) Vahl. were extracted with etha...
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Design, semi-synthesis of soft coral-derived Aspergillus sp. secondary metabolite geodin derivatives and their antibacterial activities Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-10 Gulab Said, Amjad Ali, Latif Ahmad
A series of novel ester derivatives 2 − 7, of natural product geodin 1, isolated from the soft coral-derived fungus Aspergillus sp., were designed and semi-synthesised through one step reaction wit...
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Two new alkaloids from the roots of Cocculus hirsutus (L.) W. Theob Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-10 Shivani, Surekha Kumari, Prithvi Pal Singh, Prateek Singh Bora, Upendra Sharma
Two undescribed alkaloids, 15-carboxydihydroerysotrine (1) and (14 R)-4-methoxy-13,14-dihydrooxypalmatine (2), along with six known compounds, 1,6-didehydro-3,15,16-trimethoxy-9-methylerythrinanium...
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Antioxidant constituents from Ribes glaciale Wall.: bioassay targeted in-vitro and in-silico evaluation Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-10 Rajendra Singh, Rohit Verma, Nitin Sati, Waseem Ahmad Ansari, Mohammad Faheem Khan
Bioassay targeted phyto-investigation of dried green walnut husk of Ribes glaciale Wall. yielded one new compound as β-D-glucopyrano (4′→3)-β-D-glucopyranose (1) and four known compounds namely sco...
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Siamfuranones A–C, three novel furanone derivatives from the flowers of Uvaria siamensis and their biological activities Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-05 Florian T. Schevenels, Supachai Jadsadajerm, Ratsami Lekphrom, Nuttapon Yodsin, Thanapat Suebrasri, Thanaset Senawong, Awat Wisetsai
Three previously undescribed furanone derivatives named siamfuranones A–C (1–3), together with 11 known compounds (4–14), were isolated from the flowers of Uvaria siamensis. Their planar structures...
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Synthesis, modification and biological activity of 2,3-indoles of Glycyrrhetinic acid Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-07 Lidia Baltina, Elza Karimova, Timur Nugumanov, Svetlana Petrova, Svetlana Gabdrakhmanova, Regina Khisamutdinova
The synthesis of 2,3-indoles of Glycyrrhetinic acid (GLA) and its methyl ester was carried out by the Fischer reaction. Reductive transformations of GLA methyl ester 2,3-indole 3a were carried out ...
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Tamarind genus chemical composition and biological activities Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-07 Nahla S. El-Gazzar
Tamarindus indica L., the sole species in the genus Tamarind, which is a member of the subfamily Caesalpiniaceae in the family Leguminosae (Fabaceae), is extensively dispersed in many tropical and ...
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Phytochemical profiling of Striga asiatica; characterisation and anti-microbial assessment of the isolates Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-06 Ahmed Elbermawi, Fazila Zulfiqar, Pankaj Pandey, Amar G. Chittiboyina, Ikhlas A. Khan, Zulfiqar Ali
One undescribed compound, striasinol (1), and twelve previously described compounds were isolated from the aerial parts of Striga asiatica. Structure elucidation of isolated compounds was achieved ...
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Evaluation of chalcones as new glycogen phosphorylase inhibitors – an in-vitro and in-silico approach Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-05 Talal Ahmed Awad, Fatima Alfatih, Muhammad Shafiq, Mohnad Abdalla, Samia T. Al-Shouli, Amani Bashir, Maaweya E. Awadalla, Hassan A. Alhazmi, Mohammed Albratty, Hafiz A. Makeen, Asaad Khalid, Zaheer Ul-Haq
Diabetes mellitus (DM) remains one of the pivotal diseases that have drawn the attention of researchers recently and during the last few decades. Due to its devastating symptoms, attempts to develo...
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Phytochemical composition of the diethyl ether extract of Artemisia lactiflora Wall. ex DC and its antimetastatic activity in human lung cancer cells Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-05 Nateelak Kooltheat, Kunwadee Noonong, Karl M. Hanson, Udom Lao-On
Artemisia lactiflora Wall. ex DC. is a traditional Chinese medicinal plant used in the treatment of menstrual and hepatic disorders due to its antioxidant and anti-inflammatory properties. However,...
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Determination of the volatile chemical profile of Momordica charantia (bitter melon) leaf and fruit by GC-MS Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-05 Natália Ferreira Almeida, Edenilson dos Santos Niculau, Pedro Cordeiro Toledo Lima, Wanderson Ferreira da Silva
The plant Momordica charantia (Cucurbitaceae), popularly known as bitter melon, snake fruit, Saint Vincent’s herb, or little melon, is an African species that has developed in tropical and subtropi...
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Molecular modelling approaches can reveal the Molecular interactions established between antimalarial targets of hemozoin pathway and the organic phytochemicals of Artocarpus species Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-05 Surabhi Chaurasia, Anima Pandey
Ayurveda, the traditional Indian medical system, has potential applications in early malaria treatment. In an in silico docking study, 50 phytochemicals from two plants Artocarpus lakoocha Roxb. (A...
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The investigation of hawthorn (Crataegus orientalis) plant’s inhibition effect on angiotensin converting enzyme and in silico studies Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-05 Mahmut Yavuz, Fatih Çağlar Çelikezen, Mehmet Firat, Zehra Baş, Vedat Türkoğlu
Hawthorn plant is used among people due to its cardiovascular, anti-inflammatory, and antihistamine properties. But no scientific study has been done about Crataegus orientalis (Mill.) M.Bieb. The ...
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Phytochemical profiles and evaluation of the biological potential of ethyl acetate and n-butanol fractions of the aerial parts of Cistus albidus L Nat. Prod. Res. (IF 2.2) Pub Date : 2024-03-05 Ouissem Gherboudj, Naima Boutaghane, Zahia Kabouche, Lamia Djeblia, Leila Zerrougui, Manel Bekrar
The phytochemical profiles of the ethyl acetate (EAFCA) and n-butanol (BFCA) fractions of the aerial parts of Cistus albidus L., were characterised by a developed LC-ESI-MS/MS method, using 53 fing...